keyword
MENU ▼
Read by QxMD icon Read
search

Neurotransmitters and behavior

keyword
https://www.readbyqxmd.com/read/28630618/perinatal-effects-of-scorpion-venoms-maternal-and-offspring-development
#1
REVIEW
Ana Leticia Coronado Dorce, Adriana do Nascimento Martins, Valquiria Abrão Coronado Dorce, Ana Leonor Abrahão Nencioni
Scorpion envenomation is a public health problem, especially in tropical and subtropical countries. Considering the high incidence of scorpionism in some areas, pregnant women and nursing mothers may be possible victims. Scorpion stings alter the release of neurotransmitters and some cytokines. These mediators act as organizers and programmers in the adequate formation of the nerves, and non-physiological concentrations of them during the brain organization originate disorders and diseases that can appear later in the life of the individual...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28625548/effect-of-a-change-in-housing-conditions-on-body-weight-behavior-and-brain-neurotransmitters-in-male-c57bl-6j-mice
#2
Noemi Pasquarelli, Patrizia Voehringer, Julia Henke, Boris Ferger
The development of modern housing regimes such as individually ventilated cage (IVC) systems has become very popular and attractive in order to reduce spreading of pathogenic organisms and to lower the risk to develop a laboratory animal allergy for staff members. Additionally, optimal housing of laboratory animals contributes to improve animal health status and ensures high and comparable experimental and animal welfare standards. However, it has not been clearly elucidated whether 1) a change to IVC systems have an impact on various physiological phenotypic parameters of mice when compared to conventional, standard cages and 2) if this is further affected by changing from social to single housing...
June 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28624436/zonisamide-inhibits-monoamine-oxidase-and-enhances-motor-performance-and-social-activity
#3
Maiko T Uemura, Takeshi Asano, Rie Hikawa, Hodaka Yamakado, Ryosuke Takahashi
Zonisamide (ZNS) is an effective drug for not only motor symptoms but also non-motor symptoms in Parkinson's disease. However, the actions of ZNS as an anti-Parkinsonian drug are not well understood. To clarify the actions of ZNS in vivo, we administered ZNS to mice and examined the effects on neurotransmitter metabolism and behaviors, focusing on motor and non-motor symptoms. Administration of ZNS decreased dopamine (DA) turnover in various brain regions, including the striatum. In behavioral tests, ZNS enhanced locomotor activity and novelty seeking in the open field test, light-dark transition test, and the social interaction test...
June 14, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28624333/l-theanine-prevent-quinolinic-acid-induced-motor-deficit-and-striatal-neurotoxicity-reduction-in-oxido-nitrosative-stress-and-restoration-of-striatal-neurotransmitters-level
#4
Sumit Jamwal, Shamsher Singh, Jaskamal Singh Gill, Puneet Kumar
L-theanine has been documented to possess anti-oxidant, anti-inflammatory and neuroprotective potential in various animal models of neurological disorders. The present study was anticipated to investigate the effect of L-theanine against quinolinic acid induced motor deficits, oxido-nitrosative stress, neuro-inflammation and neurotransmitters alteration in rats. Rats were stereotaxically injected QA (200 nmol/2µl saline; intrastriatal); bilaterally on 0day and L-theanine (25 & 50mg/kg; p.o.) was administered for 21 days starting from day 1 of QA injection...
June 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28623313/inhibition-of-calpains-protects-mn-induced-neurotransmitter-release-disorders-in-synaptosomes-from-mice-involvement-of-snare-complex-and-synaptic-vesicle-fusion
#5
Can Wang, Bin Xu, Zhuo Ma, Chang Liu, Yu Deng, Wei Liu, Zhao-Fa Xu
Overexposure to manganese (Mn) could disrupt neurotransmitter release via influencing the formation of SNARE complex, but the underlying mechanisms are still unclear. A previous study demonstrated that SNAP-25 is one of substrate of calpains. The current study investigated whether calpains were involved in Mn-induced disorder of SNARE complex. After mice were treated with Mn for 24 days, Mn deposition increased significantly in basal nuclei in Mn-treated and calpeptin pre-treated groups. Behaviorally, less time spent in the center of the area and decreased average velocity significantly in an open field test after 24 days of Mn exposure...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622594/the-role-of-apitoxin-in-alleviating-propionic-acid-induced-neurobehavioral-impairments-in-rat-pups-the-expression-pattern-of-reelin-gene
#6
Maha H Daghestani, Manar E Selim, Yasmina M Abd-Elhakim, Enas N Said, Noura E Abd El-Hameed, Samah R Khalil, Osama S El-Tawil
The efficacy of apitoxin (bee venom; BV) in ameliorating propionic acid (PPA) -induced neurobehavioral impacts was studied. Sixty rat pups were enrolled in a split litter design to six groups: a control group, a PPA-treated group, a BV-treated group, a BV/PPA protective group, a PPA/BV therapeutic group, and a BV/PPA/BV protective and therapeutic group. Exploratory, social, locomotor, and repetitive/stereotype-like activities were assessed and prosocial, empathy, and acquired behavior were evaluated. Levels of neurotransmitter including serotonin, dopamine, and gamma-aminobutyric acid (GABA) were determined and a quantitative analysis of Reelin gene expression was performed...
June 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28615046/the-association-of-insertions-deletions-indels-and-variable-number-tandem-repeats-vntrs-with-obesity-and-its-related-traits-and-complications
#7
REVIEW
Yee-How Say
BACKGROUND: Despite the fact that insertions/deletions (INDELs) are the second most common type of genetic variations and variable number tandem repeats (VNTRs) represent a large portion of the human genome, they have received far less attention than single nucleotide polymorphisms (SNPs) and larger forms of structural variation like copy number variations (CNVs), especially in genome-wide association studies (GWAS) of complex diseases like polygenic obesity. This is exemplified by the vast amount of review papers on the role of SNPs and CNVs in obesity, its related traits (like anthropometric measurements, biochemical variables, and eating behavior), and its related complications (like hypertension, hypertriglyceridemia, hypercholesterolemia, and insulin resistance-collectively known as metabolic syndrome)...
June 14, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28612917/neonatal-exposure-to-monosodium-glutamate-results-in-dysmorphology-of-orofacial-lower-motor-neurons
#8
Lindsey Foran, Chloe Kupelian, Swati Laroia, Jeffrey Esper, Randy Joseph Kulesza
Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and is stored and released by both neurons and astrocytes. Despite the important role of glutamate as a neurotransmitter, high levels of extracellular glutamate can result in excitotoxicity and apoptosis. Monosodium glutamate (MSG) is a naturally occurring sodium salt of glutamic acid that is used as a flavor enhancer in many processed foods. Neonatal exposure to MSG has been shown to result in neurodegeneration in several forebrain regions, characterized by neuronal loss and neuroendocrine abnormalities...
June 14, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28610974/positive-modulation-of-%C3%AE-5-gabaa-receptors-in-preadolescence-prevents-reduced-locomotor-response-to-amphetamine-in-adult-female-but-not-male-rats-prenatally-exposed-to-lipopolysaccharide
#9
Bojan Batinić, Anja Santrač, Ivan Jančić, Guanguan Li, Aleksandra Vidojević, Bojan Marković, James M Cook, Miroslav M Savić
We previously demonstrated that lipopolysaccharide (LPS) administered intraperitoneally (i.p.) to pregnant Wistar rat dams, at embryonic days 15 and 16 (E15/16), induced a decrease of baseline locomotor activity and diminished reactivity to amphetamine in adult female offspring. In the present study we aimed to assess the duration of LPS-induced maternal immune activation (MIA) and investigate possible changes in levels of main neurotransmitters in fetal brain during MIA. We hypothesized that the observed behavioral changes may be linked with MIA-induced disturbance of prenatal GABAergic system development, especially with α5 GABAA receptors (α5GABAARs), expression of which takes place between E14 and E17...
June 10, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28605494/glutamate-transport-a-new-bench-to-bedside-mechanism-for-treating-drug-abuse
#10
Sade Spencer, Peter W Kalivas
Drug addiction has often been described as a "hijacking" of the brain circuits involved in learning and memory. Glutamate is the principal excitatory neurotransmitter in the brain, and its contribution to synaptic plasticity and learning processes is well established in animal models. Likewise, over the past twenty years the addiction field has ascribed a critical role for glutamatergic transmission in the development of addiction. Chronic drug use produces enduring neuroadaptations in corticostriatal projections that are believed to contribute to a maladaptive deficit in inhibitory control over behavior...
June 12, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28603755/dysregulation-of-brain-stress-systems-mediates-compulsive-alcohol-drinking
#11
Brendan J Tunstall, Stephanie A Carmack, George F Koob, Leandro F Vendruscolo
The transition from moderate to compulsive alcohol drinking is driven by increasingly dysfunctional reward and stress systems. We review behavioral and pharmacological studies of alcohol self-administration in rats that were mainly conducted within the framework of the alcohol vapor model of dependence. We discuss neurotransmitter systems that are implicated in alcohol drinking, with a focus on contrasting those neurotransmitter systems that drive behavior in the dependent vs. nondependent states. We hypothesize that the identification of systems that become increasingly dysfunctional in alcohol dependence will reveal possible targets for successful interventions to reduce the motivation that drives compulsive alcohol drinking...
February 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28596721/cannabinoid-receptor-signaling-in-central-regulation-of-feeding-behavior-a-mini-review
#12
REVIEW
Marco Koch
Cannabinoids are lipid messengers that modulate a variety of physiological processes and modify the generation of specific behaviors. In this regard, the cannabinoid receptor type 1 (CB1) represents the most relevant target molecule of cannabinoids so far. One main function of central CB1 signaling is to maintain whole body energy homeostasis. Thus, cannabinoids functionally interact with classical neurotransmitters in neural networks that control energy metabolism and feeding behavior. The promotion of CB1 signaling can increase appetite and stimulate feeding, while blockade of CB1 suppresses hunger and induces hypophagia...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28596466/-clocks-behavior-and-cognition
#13
Akinori Futamura, Azusa Shiromaru, Takeshi Kuroda, Motoyasu Honma, Ryuta Kinno, Kenjiro Ono, Mitsuru Kawamura
The nerve center responsible for controlling our circadian rhythm is located in a cluster of cells known as the suprachiasmatic nucleus in the hypothalamus. Various physiological functions such as sleep, arousal, blood pressure, body temperature, and hormone secretion are regulated in a 24-hour rhythm by this circuit. Somatic cells of other organs have a peripheral clock gene and by synchronizing the rhythm of the central and peripheral clocks, it is possible to live a healthy life. Due to aging and degenerative disease, circadian rhythm gradually collapses...
June 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28591478/hypothalamic-hamartoma-neuropathology-and-epileptogenesis
#14
John F Kerrigan, Angela Parsons, Candy Tsang, Kristina Simeone, Stephen Coons, Jie Wu
Hypothalamic hamartomas (HHs) are congenital malformations of the ventral hypothalamus resulting in treatment-resistant epilepsy and are intrinsically epileptogenic for the gelastic seizures that are the hallmark symptom of this disorder. This paper reviews the neuropathologic features of HHs associated with epilepsy, with an emphasis on characterizing neuron phenotypes and an ultimate goal of understanding the cellular model of ictogenesis occurring locally within this tissue. We also present previously unpublished findings on Golgi staining of HH...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28587936/intra-hippocampal-microinjection-of-oxytocin-produced-antiepileptic-effect-on-the-pentylenetetrazol-induced-epilepsy-in-rats
#15
Amir Erfanparast, Esmaeal Tamaddonfard, Farzin Henareh-Chareh
BACKGROUND: In addition to its role as a circulating hormone, oxytocin can also act as a neurotransmitter and a neuromodulator within the brain. In this study, we investigated the intra-hippocampal effect of oxytocin on an experimental seizure model induced by pentylenetetrazole (PTZ) in rats. We also used atosiban (oxytocin antagonist), diazepam and flumazenil (gamma-aminobutyric acid or GABA-benzodiazepine receptor agonist and antagonist, respectively) to clarify the involved mechanism...
March 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28585882/increased-astroglial-activity-and-reduced-neuronal-function-across-brain-in-a%C3%AE-pp-ps1-mouse-model-of-alzheimer-s-disease
#16
Anant B Patel, Vivek Tiwari, Pandichelvam Veeraiah, Kamal Saba
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with progressive loss of cognitive function, personality, and behavior. The present study evaluates neuronal and astroglial metabolic activity, and neurotransmitter cycle fluxes in AβPP-PS1 mouse model of AD by using (1)H-[(13)C]-nuclear magnetic resonance (NMR) spectroscopy together with an infusion of either [1,6-(13)C2]glucose or [2-(13)C]acetate. The levels of N-acetyl-aspartate (NAA) and glutamate were found to be decreased in the cerebral cortex and hippocampus in AβPP-PS1 mice, when compared with wild type controls...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28584117/histamine-modulation-of-the-basal-ganglia-circuitry-in-the-development-of-pathological-grooming
#17
Maximiliano Rapanelli, Luciana Frick, Haruhiko Bito, Christopher Pittenger
Aberrant histaminergic function has been proposed as a cause of tic disorders. A rare mutation in the enzyme that produces histamine (HA), histidine decarboxylase (HDC), has been identified in patients with Tourette syndrome (TS). Hdc knockout mice exhibit repetitive behavioral pathology and neurochemical characteristics of TS, establishing them as a plausible model of tic pathophysiology. Where, when, and how HA deficiency produces these effects has remained unclear: whether the contribution of HA deficiency to pathogenesis is acute or developmental, and where in the brain the relevant consequences of HA deficiency occur...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28576650/steroid-metabolism-in-the-brain-from-bird-watching-to-molecular-biology-a-personal-journey
#18
REVIEW
Jacques Balthazart
Since Arnold Adolph Berthold established in 1849 the critical role of the testes in the activation of male sexual behavior, intensive research has identified many sophisticated neurochemical and molecular mechanisms mediating this action. Studies in Japanese quail demonstrated the critical role of testosterone action and of testosterone aromatization in the sexually dimorphic medial preoptic nucleus in the activation of male copulatory behavior. The development of an immunohistochemical visualization of brain aromatase in quail then allowed further refinement in the localization of the sites of neuroestrogens production...
June 4, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28573220/jieyuanshen-decoction-exerts-antidepressant-effects-on-depressive-rat-model-via-regulating-hpa-axis-and-the-level-of-amino-acids-neurotransmitter
#19
Zhang Qiuxia, Ma Xinlong, Yang Yilong, Zhao Hui, Wang Yali, Yao Xiaoquan, Wang Lei, Chang Jiahui, Zou Haiyan
BACKGROUND: Jieyuanshen decoction (JYAS-D) - a traditional Chinese medicine was invented by Professor Nie based on classic formulas, chaihu jia longgu muli decoction has been proved as having favorable curative effects on depression in clinical practices. The aim of this study was to investigate the antidepressant effects and its molecular mechanism of JYAS-D. MATERIALS AND METHODS: The model of depression was established by Chronic Unpredictable Stress. Different doses (8...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28554324/multi-target-directed-ligands-affecting-serotonergic-neurotransmission-for-alzheimer-s-disease-therapy-advances-in-chemical-and-biological-research
#20
Agnieszka Jankowska, Anna Wesołowska, Maciej Pawłowski, Grażyna Chłoń-Rzepa
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by a progressive cognitive impairments and chronic inflammation that affects over 30 million people all over the world. Most of Alzheimer's patients also suffer from psychosis, aggression, agitation, depression, anxiety, and many other behavioral and psychological symptoms of dementia. Unfortunately, currently available anti-AD drugs provide modest symptomatic relief, and do not reverse the neurodegeneration. Consequently, the average life expectancy after diagnosis is between six to ten years...
May 29, 2017: Current Medicinal Chemistry
keyword
keyword
57955
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"