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https://www.readbyqxmd.com/read/29682700/therapeutic-potential-of-a-combination-of-electroacupuncture-and-trkb-expressing-mesenchymal-stem-cells-for-ischemic-stroke
#1
Sung Min Ahn, Yu Ri Kim, Yong-Il Shin, Ki Tae Ha, Seo-Yeon Lee, Hwa Kyoung Shin, Byung Tae Choi
We prepared and grafted tropomyosin receptor kinase B (TrkB) gene-transfected mesenchymal stem cells (TrkB-MSCs) into the ischemic penumbra and investigated whether electroacupuncture (EA) treatment could promote functional recovery from ischemic stroke. For the behavioral test, TrkB-MSCs+EA resulted in significantly improved motor function compared to that obtained with MSCs+EA or TrkB-MSCs alone. At 30 days after middle cerebral artery occlusion (MCAO), the largest number of grafted MSCs was detected in the TrkB-MSC+EA group...
April 22, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29682536/in-vivo-evaluation-of-short-term-performance-of-new-three-layer-collagen-based-vascular-graft-designed-for-low-flow-peripheral-vascular-reconstructions
#2
Tomas Grus, Lukas Lambert, Mikulas Mlcek, Hynek Chlup, Eva Honsova, Miroslav Spacek, Andrea Burgetova, Jaroslav Lindner
Aim: The aim of this study was to evaluate short-term patency of the new prosthetic graft and its structural changes after explantation. Methods: The study team developed a three-layer conduit composed of a scaffold made from polyester coated with collagen from the inner and outer side with an internal diameter of 6 mm. The conduit was implanted as a bilateral bypass to the carotid artery in 7 sheep and stenosis was created in selected animals. After a period of 161 days, the explants were evaluated as gross and microscopic specimens...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682115/selection-and-determination-of-treatment-for-the-spontaneous-isolated-dissection-of-the-superior-mesenteric-artery
#3
Zaiqiang Yu, Norihiro Kondo, Mari Chiyoya, Yasuyuki Suzuki, Ikuo Fukuda
Objective : This study aimed to clarify the selection and determination of appropriate treatment for acute symptomatic spontaneous isolated dissection of the superior mesenteric artery (SIDSMA). Methods : Data from 10 consecutive patients, who were diagnosed with symptomatic SIDSMA using computed tomography angiography and were managed in our hospital from January 2010 to October 2015, were retrospectively collected and analyzed. Results : There were nine males and one female; mean patient age was 50.3 (range, 35-64) years...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29682091/effectiveness-of-platelet-rich-plasma-and-bone-graft-in-the-treatment-of-intrabony-defects-a-clinico-radiographic-study
#4
Mohammad Jalaluddin, Jayachandran Mahesh, Rethi Mahesh, Ipsita Jayanti, Mohamed Faizuddin, Krishna Kripal, Nazia Nazeer
Background & Objectives: Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, loss of connective tissue attachment and alveolar bone around the affected tooth. Different modalities have been employed in the treatment and regeneration of periodontal defects which include the use of bone grafts, PRP and other growth factors.The purpose of this prospective, randomized controlled study was to compare the regenerative efficacy of PRP and bonegraft in intrabony periodontal defects...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29680515/safety-and-efficacy-of-once-daily-intravenous-busulfan-in-allogeneic-transplantation-a-matched-pair-analysis
#5
Shinichi Kako, Shinichiro Fujiwara, Miki Sato, Shun-Ichi Kimura, Hideki Nakasone, Kazuteru Ohashi, Toshiro Kawakita, Tetsuo Maeda, Takanobu Morishita, Ritsuro Suzuki, Takahiro Fukuda, Tatsuo Ichinohe, Mio Kurata, Yoshiko Atsuta, Yoshinobu Kanda
Compared with 4-times-daily infusion of intravenous busulfan (ivBU4), the safety and efficacy of once-daily infusion of ivBU (ivBU1) has not been fully clarified. We have been routinely using ivBU1 in a conditioning regimen in adult patients with myeloid malignancy who undergo allogeneic hematopoietic stem cell transplantation. In this study, a total of 91 patients who received ivBU1 for 2 days (n = 18) or 4 days (n = 73) in our institutions were compared with 273 control patients who received ivBU4, who were matched for age, sex, performance status, disease risk, conditioning regimen, and donor type, selected from the database of the Japanese Society for Hematopoietic Cell Transplantation using optimal matching algorithms...
April 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29680298/experimental-evaluation-of-homemade-distal-stent-graft-fenestration-for-thoracic-endovascular-aortic-repair-of-type-a-dissection-by-a-transapical-approach
#6
Thomas Gandet, Anis Seghrouchni, Baris Ata Ozdemir, Guillaume Captier, Roland Demaria, Pierre Alric, Bernard Albat, Ludovic Canaud
OBJECTIVE: The use of off-the-shelf stent grafts for thoracic endovascular aortic repair of type A dissections is limited by variability in both the length of the ascending aorta and the location of the proximal intimal tear. This experimental study aimed to assess the feasibility of using a physician-modified thoracic aortic stent graft to treat acute type A dissection by a transapical cardiac approach. METHODS: The experiments were performed on six cadaveric human heart, ascending aorta, aortic arch, and descending aorta specimens...
April 18, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29680218/hybrid-coronary-revascularization-in-selected-patients-with-multivessel-disease-5-year-clinical-outcomes-of-the-prospective-randomized-pilot-study
#7
Mateusz Tajstra, Tomasz Hrapkowicz, Michał Hawranek, Krzysztof Filipiak, Marek Gierlotka, Marian Zembala, Mariusz Gąsior, Michael Oscar Zembala
OBJECTIVES: This study aimed to investigate the 5-year clinical follow-up of the Hybrid Revascularization for Multivessel Coronary Artery Disease (HYBRID) trial. BACKGROUND: HYBRID trial, the only randomized study involving thorough analysis of outcome after the 2 procedures, suggested that hybrid coronary revascularization (HCR) is feasible in selected patients with multivessel coronary disease referred for conventional coronary artery bypass grafting (CABG). There are currently no long-term outcome data from randomized trials in this setting...
April 12, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29679587/orbital-floor-reconstruction-3-dimensional-analysis-shows-comparable-morphology-of-scapular-and-iliac-crest-bone-grafts
#8
Joel C Davies, Harley H L Chan, Jonathan M Bernstein, David P Goldstein, Jonathan C Irish, Ralph W Gilbert
PURPOSE: Current nonvascular osseous reconstructive options for reconstruction of the orbital floor after maxillectomy include options such as scapular tip and iliac crest bone grafts. The aim of this study was to determine whether these donor sites were morphologically comparable with the orbital floor. MATERIALS AND METHODS: A retrospective cross-sectional study design was selected. By use of a pre-existing melanoma database (January 1, 2005, through September 20, 2015), computed tomography scans of the head, neck, thorax, and pelvis were obtained from patients without evidence of bony metastases...
March 28, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29679208/revision-pcl-reconstruction-review-update
#9
REVIEW
G Keith Gill, F Winston Gwathmey
PURPOSE OF REVIEW: The primary goal of this review is to update recent literature on revision PCL reconstruction and to discuss factors relevant to surgical failure, surgical indications and goals, patient evaluation, surgical decision-making, graft selection, surgical technique, associated surgical procedures, postoperative rehabilitation, and revision PCL reconstruction results. RECENT FINDINGS: Specifically, it is paramount to consider and treat posteromedial and posterolateral instability...
April 20, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29677070/heavy-alcohol-use-among-deceased-donors-does-not-impact-recipient-outcomes-after-liver-transplantation
#10
Sumant S Arora, Khushdeep S Chahal, Page Axley, Devin E Eckhoff, Yong-Fang Kuo, Sanjaya K Satapathy, Russell Wiesner, Ashwani K Singal
BACKGROUND: Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks/day) are scanty. METHODS: Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with not heavy drinking (ND) donors. RESULTS: Of 56 182 first LTs performed in the US for 10 common indications using deceased donors, 47 882 with available information on alcohol use were analyzed...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29676561/highly-stable-mesoporous-luminescence-functionalized-mof-with-excellent-electrochemiluminescence-property-for-ultrasensitive-immunosensor-construction
#11
Gui-Bing Hu, Cheng-Yi Xiong, Wen-Bin Liang, Xiao-Shan Zeng, Hui-Ling Xu, Yang Yang, Li-Ying Yao, Ruo Yuan, Dong-Rong Xiao
In this work, a novel mesoporous luminescence-functionalized metal-organic framework (Ru-PCN-777) with high stability and excellent electrochemiluminescence (ECL) performance was synthesized by immobilizing Ru(bpy)2(mcpbpy)2+ on the Zr6 cluster of PCN-777 via a strong coordination bond between Zr4+ and -COO-. Consequently, the Ru(bpy)2(mcpbpy)2+ could not only cover the surface of PCN-777, but also grafted into the interior of PCN-777, which greatly increased the loading amount of Ru(bpy)2(mcpbpy)2+ and effectively prevented the leaching of the Ru(bpy)2(mcpbpy)2+ resulting in a stable and high ECL response...
April 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29676158/hierarchical-fau-zif-8-hybrid-materials-as-highly-efficient-acid-base-catalysts-for-aldol-condensation
#12
Duangkamon Suttipat, Wannaruedee Wannapakdee, Thittaya Yutthalekha, Somlak Ittisanronnachai, Thasanaporn Ungpittagul, Khamphee Phomphrai, Sareeya Bureekaew, Chularat Wattanakit
The composite of hierarchical faujasite nanosheets and zeolitic imidazolate framework-8 (Hie-FAU/ZIF-8) has been successfully prepared via a stepwise deposition of ZIF-8 on modified zeolite surfaces. Compared to the direct deposition of MOF on zeolite surfaces, ZIF-8 nanospheres were selectively attached to external surfaces of the MOF ligand-grafted FAU crystals because of the enhancing interaction between zeolite and MOF in the composite. In addition, the degree of surface functionalization can be greatly enhanced due to the presence of hierarchical structures...
April 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29675688/everyone-has-a-donor-contribution-of-the-chinese-experience-to-global-practice-of-haploidentical-hematopoietic-stem-cell-transplantation
#13
REVIEW
Meng Lv, Yingjun Chang, Xiaojun Huang
Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) have long been scarce in China. Haploidentical (haplo) donors are available for the vast majority of patients, but toxicity has limited this approach. Three new approaches for haplo-HSCT originated from Italy, China, and USA in 1990 and have been developed to world-renowned system up to now. The Chinese approach have been greatly improved by implementing new individualized conditioning regimens, donor selection based on non-HLA systems, risk-directed strategies for graft-versus-host disease and relapse, and infection management...
April 19, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29671538/stable-coronary-artery-disease-treatment
#14
Michael M Braun, William A Stevens, Craig H Barstow
Stable coronary artery disease refers to a reversible supply/demand mismatch related to ischemia, a history of myocardial infarction, or the presence of plaque documented by catheterization or computed tomography angiography. Patients are considered stable if they are asymptomatic or their symptoms are controlled by medications or revascularization. Treatment involves risk factor management, antiplatelet therapy, and antianginal medications. Tobacco cessation, exercise, and weight loss are the most important lifestyle modifications...
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29670652/combined-dorsal-and-ventral-onlay-buccal-graft-technique-for-large-and-complex-penile-strictures
#15
Nikolaos Mertziotis, Andreas Konandreas, Christos Kyratsas
Purpose: To present a modified technique of managing extensive penile urethral strictures with dorsal and ventral onlay buccal mucosa grafts. Patients and Methods: From October 2014 to January 2016, a total of 12 patients underwent urethroplasty for penile urethral strictures, using dorsal and ventral onlay grafts from buccal mucosa. The mean age was 42.75 (17-71). All patients completed the IPSS and QoL questionnaire, and uroflowmetry was done preoperatively. After surgery, the follow-up included completion of IPSS and QoL questionnaire and measuring of uroflow at 1, 3, 6, and 12 months...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29668554/long-term-clinical-outcomes-after-coronary-artery-bypass-graft-versus-everolimus-eluting-stent-implantation-in-chronic-hemodialysis-patients
#16
Yoshitaka Kumada, Hideki Ishii, Toru Aoyama, Daisuke Kamoi, Takashi Sakakibara, Norio Umemoto, Ryuta Ito, Hiroshi Takahashi, Toyoaki Murohara
BACKGROUND: It remains controversial whether coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI) should be optimized to treat coronary artery disease in patients on chronic hemodialysis (HD). Recently, further refinement of drug-eluting stents, such as the everolimus-eluting stent (EES), has led to marked development in this field. We compared long-term clinical outcomes after CABG versus PCI with EES implantation in patients on chronic HD. PATIENTS AND METHODS: We compared 138 patients undergoing CABG and 187 patients treated with EES implantation...
April 17, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29668505/comparison-of-functional-results-after-cross-face-nerve-graft-spinal-accessory-nerve-and-masseter-nerve-innervated-gracilis-for-facial-paralysis-reconstruction-the-chang-gung-experience
#17
David Chwei-Chin Chuang, Johnny Chuieng-Yi Lu, Tommy Nai-Jen Chang, Vincent G Laurence
BACKGROUND: Using functioning free muscle transplantation (FFMT) for facial paralysis and postparalysis facial synkinesis reconstruction is our preferred technique. Gracilis was the first choice of muscle. Three motor neurotizers: cross-face nerve graft (CFNG), spinal accessory nerve (XI) and masseter nerve (V3) have been used as neurotizers for different indications. METHODS: A total of 362 cases of facial reanimation with FFMT were performed between 1986 and 2015...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29666562/preclinical-in-vitro-and-in-vivo-evaluation-of-18-f-fe-suppy-for-cancer-pet-imaging-limitations-of-a-xenograft-model-for-colorectal-cancer
#18
T Balber, J Singer, N Berroterán-Infante, M Dumanic, L Fetty, J Fazekas-Singer, C Vraka, L Nics, M Bergmann, K Pallitsch, H Spreitzer, W Wadsak, M Hacker, E Jensen-Jarolim, H Viernstein, M Mitterhauser
Molecular imaging probes such as PET-tracers have the potential to improve the accuracy of tumor characterization by directly visualizing the biochemical situation. Thus, molecular changes can be detected early before morphological manifestation. The A3 adenosine receptor (A3 AR) is described to be highly expressed in colon cancer cell lines and human colorectal cancer (CRC), suggesting this receptor as a tumor marker. The aim of this preclinical study was the evaluation of [18 F]FE@SUPPY as a PET-tracer for CRC using in vitro imaging and in vivo PET imaging...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29665749/early-and-mid-term-results-in-the-endovascular-treatment-of-popliteal-aneurysms-with-the-multilayer-flow-modulator
#19
Alessandro Ucci, Ruggiero Curci, Matteo Azzarone, Claudio Bianchini Massoni, Antonio Bozzani, Carla Marcato, Enrico Maria Marone, Paolo Perini, Tiziano Tecchio, Antonio Freyrie, Angelo Argenteri
Background The endovascular approach became an alternative to open surgical treatment of popliteal artery aneurysm over the last few years. Heparin-bonded stent-grafts have been employed for endovascular popliteal artery aneurysm repair, showing good and stable results. Only few reports about the use of multilayer flow modulator are available in literature, providing small patient series and short follow-up. The aim of this study is to report the outcomes of patients with popliteal artery aneurysm treated with the multilayer flow modulator in three Italian centres...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29664651/nanocomposite-membrane-with-polyethylenimine-grafted-graphene-oxide-as-a-novel-additive-to-enhance-pollutant-filtration-performance
#20
Lina Zhang, Baoliang Chen, Abdul Ghaffar, Xiaoying Zhu
Synthetic membranes often suffer ubiquitous fouling as well as a trade-off between permeability and selectivity. However, emerging materials which are able to mitigate membrane fouling and break the permeability and selectivity trade-off are urgently needed. A novel additive, GO-PEI, bearing a positive charge and hydrophilic nature was prepared by the covalent grafting of polyethylenimine (PEI) molecules with graphene oxide (GO) nanosheets, which later was blended with bulk polyethersulfone (PES) to fabricate the graphene containing nanocomposite membranes (NCMs)...
April 17, 2018: Environmental Science & Technology
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