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2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Carl Goforth, David Antico
No abstract text is available yet for this article.
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Frank K Butler
No abstract text is available yet for this article.
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Andre Pennardt, Rich Kamin, Craig Llewellyn, Geoff Shapiro, Philip A Carmona, Richard B Schwartz
Tactical emergency medical support (TEMS) is a critical component of the out-of-hospital response to domestic high-threat incidents such as hostage scenarios, warrant service, active shooter or violent incidents, terrorist attacks, and other intentional mass casualty-producing acts. From its grass-roots inception in the form of medical support of select law enforcement special weapons and tactics (SWAT) units in the 1980s, the TEMS subspecialty of prehospital care has rapidly grown and evolved over the past 40 years...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
John B Robinson, Michael P Smith, Kirby R Gross, Samual W Sauer, James J Geracci, Charlie D Day, Russ S Kotwal
Performance improvement is reliant on information and data, as you cannot improve what you do not measure. The US military went to war in 2001 without an integrated trauma care system to collect and analyze combat casualty care data. By 2006, the conflict in Afghanistan began appreciating the capture and consolidation of hospital care documentation into the Department of Defense Trauma Registry. In contrast, a paucity of documentation has existed for prehospital or tactical combat casualty care (TCCC). Using the 75th Ranger casualty documentation model established in 2005, the Joint Trauma System developed a casualty data collection system for prehospital care using the TCCC Card, the TCCC After Action Report (AAR), and the Prehospital Trauma Registry...
April 2016: U.S. Army Medical Department Journal
Xiufeng Shi, Chuanyou Chang, Shenxi Ma, Yibing Cheng, Jun Zhang, Qiang Gao
This work investigated the efficient bioconversion process of L-glutamate to GABA by Lactobacillus brevis TCCC 13007 resting cells. The optimal bioconversion system was composed of 50 g/L 48 h cultivated wet resting cells, 0.1 mM pyridoxal phosphate in glutamate-containing 0.6 M citrate buffer (pH 4.5) and performed at 45 °C and 180 rpm. By 10 h bioconversion at the ratio of 80 g/L L-glutamic acid to 240 g/L monosodium glutamate, the final titer of GABA reached 201.18 g/L at the molar bioconversion ratio of 99...
May 7, 2016: Journal of Industrial Microbiology & Biotechnology
Kyle Sims, Harold R Montgomery, Paul Dituro, Bijan S Kheirabadi, Frank K Butler
Exsanguination from wounds in the so-called junctional regions of the body (i.e., the neck, the axilla, and the groin) was responsible for 19% of the combat fatalities who died from potentially survivable wounds sustained in Afghanistan or Iraq during 2001 to 2011. The development of improved techniques and technology to manage junctional hemorrhage has been identified in the past as a high-priority item by the Committee on Tactical Combat Casualty Care (CoTCCC) and the Army Surgeon General's Dismounted Complex Blast Injury (DCBI) Task Force...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Grace C Haser, R Michael Tuttle, Henry K Su, Eran E Alon, Donald Bergman, Victor Bernet, Elise Brett, Rhoda Cobin, Eliza H Dewey, Gerard Doherty, Laura L Dos Reis, Jeffrey Harris, Joshua Klopper, Stephanie L Lee, Robert A Levine, Stephen J Lepore, Ilya Likhterov, Mark A Lupo, Josef Machac, Jeffrey I Mechanick, Saral Mehra, Mira Milas, Lisa A Orloff, Gregory Randolph, Tracey A Revenson, Katherine J Roberts, Douglas S Ross, Meghan E Rowe, Robert C Smallridge, David Terris, Ralph P Tufano, Mark L Urken
OBJECTIVE: The dramatic increase in papillary thyroid carcinoma (PTC) is primarily a result of early diagnosis of small cancers. Active surveillance is a promising management strategy for papillary thyroid microcarcinomas (PTMCs). However, as this management strategy gains traction in the U.S., it is imperative that patients and clinicians be properly educated, patients be followed for life, and appropriate tools be identified to implement the strategy. METHODS: We review previous active surveillance studies and the parameters used to identify patients who are good candidates for active surveillance...
May 2016: Endocrine Practice
C William Schwab
This White Paper summarizes the state of readiness of combat surgeons and provides action recommendations that address the problems of how to train, sustain, and retain them for future armed conflicts. As the basis for the 2014 Scudder Oration, I explored how to secure an improved partnership between military and civilian surgery, which would optimize learning platforms and embed military trauma personnel at America's academic medical universities for trauma combat casualty care (TCCC). To craft and validate these recommendations, I conducted an integrative and iterative process of literature reviews, interviews of military and civilian leaders, and a survey of military-affiliated surgeons...
August 2015: Journal of the American College of Surgeons
Samual W Sauer, John B Robinson, Michael P Smith, Kirby R Gross, Russ S Kotwal, Robert L Mabry, Frank K Butler, Zsolt T Stockinger, Jeffrey A Bailey, Mark E Mavity, Duncan A Gillies
The United States has achieved unprecedented survival rates, as high as 98%, for casualties arriving alive at the combat hospital. Our military medical personnel are rightly proud of this achievement. Commanders and Servicemembers are confident that if wounded and moved to a Role II or III medical facility, their care will be the best in the world. Combat casualty care, however, begins at the point of injury and continues through evacuation to those facilities. With up to 25% of deaths on the battlefield being potentially preventable, the prehospital environment is the next frontier for making significant further improvements in battlefield trauma care...
2015: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Dana J Onifer, Frank K Butler, Kirby R Gross, Edward J Otten, Robert Patton, Robert J Russell, Zsolt Stockinger, Elizabeth Burrell
The current Tactical Combat Casualty Care (TCCC) Guidelines recommend parenteral promethazine as the single agent for the treatment of opioid-induced nausea and/or vomiting and give a secondary indication of "synergistic analgesic effect." Promethazine, however, has a well-documented history of undesired side effects relating to impairment and dysregulation of the central and autonomic nervous systems, such as sedation, extrapyramidal symptoms, dystonia, impairment of psychomotor function, neuroleptic malignant syndrome, and hypotension...
2015: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Steven G Schauer, John B Robinson, Robert L Mabry, Jeffrey T Howard
BACKGROUND: Servicemembers injured in combat often experience moderate to severe acute pain. Early and effective pain control in the prehospital setting has been shown to reduce the sequelae of untreated pain. Current data suggest that lack of point-of-injury (POI) analgesia has significant, downstream effects on healthcare quality and associated costs. METHODS: This was a process improvement project to determine the current rate of adherence to existing prehospital pain management guidelines...
2015: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Adam B McGarry, Jeffrey C Mott, Russ S Kotwal
Documentation of medical care provided is paramount for improving performance and ultimately reducing morbidity and mortality. However, documentation of prehospital trauma care on the battlefield has historically been suboptimal. Modernization of prehospital documentation tools have aligned data and information to be gathered with up-to-date treatment being rendered through Tactical Combat Casualty Care (TCCC) protocols and practices. Our study was conducted to evaluate TCCC Card completion, and accuracy of card completion, by military medical providers conducting precombat training through the Tactical Combat Medical Care Course...
2015: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Stacy A Shackelford, Frank K Butler, John F Kragh, Rom A Stevens, Jason M Seery, Donald L Parsons, Harold R Montgomery, Russ S Kotwal, Robert L Mabry, Jeffrey A Bailey
No abstract text is available yet for this article.
2015: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Xing Zhang, Yanyuan Li, Xiang Li, Wanjiang Zhang, Zhifen Pan, Fang Wu, Chong Wang, Zhongliang Chen, Tingting Jiang, Dandan Xu, Zepeng Ping, Jiyan Liu, Changming Liu, Zhongjie Li, Ji-Cheng Li
BACKGROUND: Single nucleotide polymorphisms (SNPs) within precursor microRNAs (miRNAs) can affect miRNAs expression, and may be involved in the pathogenesis of pulmonary tuberculosis (TB). This study aimed to investigate potential associations between the four precursor miRNA SNPs (miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 T > C) and susceptibility to pulmonary TB in the Chinese Uygur, Kazak, and Southern Han populations. METHODS: A case-control study was performed on Chinese Uygur (n = 662), Kazak (n = 612), and Southern Han (n = 654) populations using the PCR-PFLR method...
2015: BMC Infectious Diseases
M R Frazão, J P Falcão
AIMS: To investigate the pathogenic potential and genotypic diversity of Yersinia enterocolitica biotype 2 strains isolated in Brazil and to compare these strains with other Y. enterocolitica biotypes using ERIC-PCR and PFGE. METHODS AND RESULTS: Forty strains of Y. enterocolitica biotype 2 (B2) isolated from humans (5), the environment (34) and animal (1), in Brazil over 19 years were studied. In addition to these isolates, we also analysed 26 Y. enterocolitica strains belonging to the biotypes 1A, 1B, and 3-5...
April 2015: Journal of Applied Microbiology
Eric T Wong, Edwin Lok, Kenneth D Swanson
The NovoTTF-100A is a device that emits alternating electric fields and it is approved for the treatment of recurrent glioblastoma. It works by perturbing tumor cells during mitosis as they enter anaphase leading to aneuploidy, asymmetric chromosome segregation and cell death with evidence of increased immunogenicity. Clinical trial data have shown equivalent efficacy when compared to salvage chemotherapies in recurrent disease. Responders were found to have had a lower dexamethasone usage and a higher rate of prior low-grade histology...
March 2015: Cancer Medicine
Rili Xie, Yanbing Shen, Ning Qin, Yibo Wang, Liqiu Su, Min Wang
Mycobacterium neoaurum TCCC 11028 (MNR) and M. neoaurum TCCC 11028 M3 (MNR M3) significantly differ in the ratio of androst-1,4-diene-3,17-dione (ADD) to androst-4-ene-3,17-dione (AD) produced. The large fluctuations are related to the dehydrogenation activity of 3-ketosteroid-Δ(1)-dehydrogenase (KsdD). Analysis of the primary structure of KsdD showed that the Ser-138 of KsdD-MNR changed to Leu-138 of KsdD-MNR M3 because of C413T in the ksdD gene. This phenomenon directly affected KsdD activity. The effect of the primary structure of KsdD on dehydrogenation activity was confirmed through exogenous expression...
April 2015: Journal of Industrial Microbiology & Biotechnology
Saral Mehra, R Michael Tuttle, Mira Milas, Lisa Orloff, Donald Bergman, Victor Bernet, Elise Brett, Rhoda Cobin, Gerard Doherty, Benjamin L Judson, Joshua Klopper, Stephanie Lee, Mark Lupo, Josef Machac, Jeffrey I Mechanick, Gregory Randolph, Douglas S Ross, Robert Smallridge, David Terris, Ralph Tufano, Eran Alon, Jason Clain, Laura DosReis, Sophie Scherl, Mark L Urken
BACKGROUND: Health registries have become extremely powerful tools for cancer research. Unfortunately, certain details and the ability to adapt to new information are necessarily limited in current registries, and they cannot address many controversial issues in cancer management. This is of particular concern in differentiated thyroid cancer, which is rapidly increasing in incidence and has many unknowns related to optimal treatment and surveillance recommendations. SUMMARY: In this study, we review different types of health registries used in cancer research in the United States, with a focus on their advantages and disadvantages as related to the study of thyroid cancer...
February 2015: Thyroid: Official Journal of the American Thyroid Association
Chenglin Zhang, Yuan Liu, Ning Xue, Xinxin Wang, Xixian Xie, Qingyang Xu, Ning Chen
OBJECTIVE: L-isoleucine-4-hydroxylase (IDO) encoding gene ido from Bacillus thuringiensis TCCC 11826 was cloned and expressed, followed by enzyme characterization. In addition, recombinant strain was tested for its 4-Hydroxyisoleucine (4-HIL) biotransformation. METHODS: Ido gene was amplified from B. thuringiensis TCCC 11826 genomic DNA and expressed in BL-IDO. Recombinant IDO was extracted, purified and characterized. Recombinant strain used for biotransformation of 4-HIL was constructed...
August 4, 2014: Wei Sheng Wu Xue Bao, Acta Microbiologica Sinica
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