keyword
MENU ▼
Read by QxMD icon Read
search

Anemia hematological cancer blood

keyword
https://www.readbyqxmd.com/read/27884348/prognostic-relevance-of-hematological-profile-before-resection-for-colorectal-liver-metastases
#1
Ulf Kulik, Harald Schrem, Hueseyin Bektas, Juergen Klempnauer, Frank Lehner
BACKGROUND: Although alterations of hematological profile and especially elevated platelet counts were reported to influence survival in primary colorectal cancer, its prognostic relevance before the surgical treatment of colorectal liver metastases (CLM) is mainly unclear. Therefore, the aim of this study was to analyze the impact of these factors on overall survival following liver resection of CLM. MATERIALS AND METHODS: The surgical treatment of primary CLM between 1994 and 2012 in 983 patients was retrospectively analyzed using univariable and multivariable Cox regression models...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27872759/impact-of-moderate-intensity-aerobic-exercise-on-chemotherapy-induced-anemia-in-elderly-women-with-breast-cancer-a-randomized-controlled-clinical-trial
#2
Heba M Mohamady, Hany F Elsisi, Yasser M Aneis
Exercises are often recommended for patients suffering from anemia to improve physical conditioning and hematologic parameters. Hence, the present study aimed to investigate the impact of moderate intensity aerobic exercise on chemotherapy-induced anemia. Thirty elderly women with breast cancer underwent chemotherapy and were randomly assigned into two equal groups; Group A received aerobic exercise for 25-40 min at 50-70% of the maximum heart rate, 3 times/week for 12 weeks in addition to usual daily living activities, medication and nutritional support...
January 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/27802181/carboplatin-induced-hematotoxicity-among-patients-with-non-small-cell-lung-cancer-analysis-on-clinical-adverse-events-and-drug-gene-interactions
#3
Yi-Ju Cheng, Ran Wu, Ming-Liang Cheng, Juan Du, Xi-Wei Hu, Lei Yu, Xue-Ke Zhao, Yu-Mei Yao, Qi-Zhong Long, Li-Li Zhu, Juan-Juan Zhu, Ni-Wen Huang, Hua-Juan Liu, Ya-Xin Hu, Fang Wan
In order to clarify the risk of hematotoxicity of carboplatin, we inspected 19901 case reports of non-small cell lung cancer patients that were submitted to the FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015. These comprised 3907 cases which were treated with carboplatin and 15994 cases which were treated with other therapies in the absence of carboplatin. By comparison, carboplatin cases were significantly more likely to report anemia (OR = 2.27, 95% CI 1.85-2.78, P = 5.04×10-15), neutropenia (OR = 2...
October 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27443994/neurologic-manifestations-of-blood-dyscrasias
#4
REVIEW
Daniel R Couriel, Holly Ricker, Mary Steinbach, Catherine J Lee
Neurologic manifestations are common in blood diseases, and they can be caused by the hematologic disorder or its treatment. This article discusses hematologic diseases in adult patients, and categorizes them into benign and malignant conditions. The more common benign hematologic diseases associated with neurologic manifestations include anemias, particularly caused by B12 deficiency and sickle cell disease, and a variety of disorders of hemostasis causing bleeding or thrombosis, including thrombotic microangiopathy...
August 2016: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/27442668/bi-cytopenia-possibly-induced-by-anti-pd-1-antibody-for-primary-malignant-melanoma-of-the-esophagus-a-case-report
#5
Kyoko Inadomi, Hozumi Kumagai, Shuji Arita, Nobuhiro Tsuruta, Kotoe Takayoshi, Koji Mishima, Shun-Ichiro Ota, Mamoru Tanaka, Yuta Okumura, Kosuke Sagara, Kenta Nio, Michitaka Nakano, Hiroshi Uchi, Hidetaka Yamamoto, Hiroshi Ariyama, Hitoshi Kusaba, Hiroaki Niiro, Yoshinao Oda, Koichi Akashi, Eishi Baba
BACKGROUND: Anti-programmed cell death 1 antibody nivolumab is a promising agent for various cancers. Immune-related adverse events are recognized; however, bi-cytopenia with nivolumab has not been reported. CASE PRESENTATION: A 73-year-old man was diagnosed with advanced primary malignant melanoma of the esophagus with liver, lung, and lymph node metastases. Previous therapies including dacarbazine and radiation of 39 Gy to the esophageal region were performed, but the liver metastases deteriorated...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27423975/review-of-hematological-indices-of-cancer-patients-receiving-combined-chemotherapy-radiotherapy-or-receiving-radiotherapy-alone
#6
REVIEW
Saman Shahid
We observed the outcomes of chemotherapy with radiotherapy (CR) or radiotherapy (RT) alone for cancer patients of larynx, breast, blood and brain origins through complete blood count (CBC). Following were more depressed in CR patients: mean corpuscular hemoglobin-MCH & lymphocytes-LYM, hematocrit, mean corpuscular hemoglobin concentration-MCHC, hemoglobin-HB and red blood cells-RBC. In RT patients, following were more depressed: LYM, MCH and MCHC. Overall, in all cancer patients, the lymphocytes were depressed 52%...
September 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27400009/abnormal-uterine-bleeding-as-the-presenting-symptom-of-hematologic-cancer
#7
Denise R Nebgen, Helen E Rhodes, Cynthia Hartman, Mark F Munsell, Karen H Lu
OBJECTIVE: To estimate the percentage of women with a hematologic cancer who present with abnormal uterine bleeding (AUB). METHODS: We performed a retrospective analysis of the records of women with hematologic malignancies treated at our institution from January 2002 through January 2016. Women with AUB as the chief presenting symptom were identified. RESULTS: Of the 10,682 women with hematologic malignancies, 38 had AUB as their chief presenting symptom...
August 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27345141/preemptive-bone-marrow-transplantation-and-event-free-survival-in-fanconi-anemia
#8
Nicholas E Khan, Philip S Rosenberg, Blanche P Alter
Fanconi anemia (FA) is a rare inherited bone marrow failure syndrome associated with high risks of severe bone marrow failure (BMF), acute myeloid leukemia (AML), and solid tumors (ST). Bone marrow transplantation (BMT) provides a theoretical cure for hematologic risks (BMF, AML), but it introduces uncertain risks of transplantation-related mortality (TRM) and carcinogenicity. We developed a mathematical (Markov) decision model to estimate event-free survival (EFS) conditional on age based on per-year cause-specific hazard rates...
October 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#9
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27217780/a-phase-ii-prospective-nonrandomized-trial-of-magnetic-resonance-imaging-guided-hematopoietic-bone-marrow-sparing-radiotherapy-for-gastric-cancer-patients-with-concurrent-chemotherapy
#10
Jianyang Wang, Yuan Tian, Yuan Tang, Xin Wang, Ning Li, Hua Ren, Hui Fang, Yanru Feng, Shulian Wang, Yongwen Song, Yueping Liu, Weihu Wang, Yexiong Li, Jing Jin
PURPOSE: This study aimed to spare hematopoietical bone marrow (BM) identified by magnetic resonance (MR) radiation in order to alleviate acute hematologic toxicity (HT) for gastric cancer patients treated with postoperative chemoradiotherapy (CRT). METHODS: A prospective, open-label, single-arm Phase II study (Clinicaltrials.gov; NCT 01863420) was conducted in 25 patients with gastric cancer who were eligible for postoperative concurrent CRT. The MR images of vertebral body T8-L4 were fused with images of simulating computed tomography...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27164956/utility-of-day-8-blood-tests-on-platinum-plus-vinorelbine-regimen
#11
Rocío Vázquez-Sánchez, Raúl Diez-Fernández, Santos Enrech-Frances, Ana Sánchez-Peña, Teresa Molina-García
Background The combination of cisplatin or carboplatin with vinorelbine is one of the standard regimens in non-small-cell lung cancer. Some studies have shown that the hemogram on day-8 could be avoided in patients with cisplatin. However, carboplatin had not been studied and is considered to be more myelotoxic than cisplatin. Objective To quantify the incidence of thrombocytopenia, anemia, neutropenia and impaired liver and renal tests on day 8 in patients receiving a doublet protocol including a platinum and vinorelbine...
August 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27068103/treatment-with-anti-il-6-receptor-antibody-prevented-increase-in-serum-hepcidin-levels-and-improved-anemia-in-mice-inoculated-with-il-6-producing-lung-carcinoma-cells
#12
Mariko Noguchi-Sasaki, Yusuke Sasaki, Yasushi Shimonaka, Kazushige Mori, Kaori Fujimoto-Ouchi
BACKGROUND: Hepcidin, a key regulator of iron metabolism, is produced mainly by interleukin-6 (IL-6) during inflammation. A mechanism linking cancer-related anemia and IL-6 through hepcidin production is suggested. To clarify the hypothesis that overproduction of IL-6 elevates hepcidin levels and contributes to the development of cancer-related anemia, we evaluated anti-IL-6 receptor antibody treatment of cancer-related anemia in an IL-6-producing human lung cancer xenograft model. METHODS: Nude mice were subcutaneously inoculated with cells of the IL-6-producing human lung cancer cell line LC-06-JCK and assessed as a model of cancer-related anemia...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27044938/phase-i-study-of-ly2606368-a-checkpoint-kinase-1-inhibitor-in-patients-with-advanced-cancer
#13
David Hong, Jeffrey Infante, Filip Janku, Suzanne Jones, Ly M Nguyen, Howard Burris, Aung Naing, Todd M Bauer, Sarina Piha-Paul, Faye M Johnson, Razelle Kurzrock, Lisa Golden, Scott Hynes, Ji Lin, Aimee Bence Lin, Johanna Bendell
PURPOSE: The primary objective was to determine safety, toxicity, and a recommended phase II dose regimen of LY2606368, an inhibitor of checkpoint kinase 1, as monotherapy. PATIENTS AND METHODS: This phase I, nonrandomized, open-label, dose-escalation trial used a 3 + 3 dose-escalation scheme and included patients with advanced solid tumors. Intravenous LY2606368 was dose escalated from 10 to 50 mg/m(2) on schedule 1 (days 1 to 3 every 14 days) or from 40 to 130 mg/m(2) on schedule 2 (day 1 every 14 days)...
May 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27037814/dosimetric-predictors-of-acute-hematologic-toxicity-during-concurrent-intensity-modulated-radiotherapy-and-chemotherapy-for-anal-cancer
#14
P Franco, R Ragona, F Arcadipane, M Mistrangelo, P Cassoni, N Rondi, M Morino, P Racca, U Ricardi
PURPOSE: This study aimed at investigating whether the irradiated volume of pelvic bone marrow (PBM) and specific subsites may predict the occurrence of acute hematologic toxicity (HT) in anal cancer patients undergoing concurrent chemo-radiation. METHODS: 50 patients, submitted to IMRT and concurrent chemotherapy, were analyzed. Several bony structures were defined on planning-CT: PBM and lumbar-sacral (LSBM), lower pelvis (LPBM) and iliac (IBM) bone marrow. On dose-volume histograms, dosimetric parameters were taken...
April 1, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/26966573/antianemic-treatment-of-cancer-patients-in-german-routine-practice-data-from-a-prospective-cohort-study-the-tumor-anemia-registry
#15
Tilman Steinmetz, Jan Schröder, Margarete Plath, Hartmut Link, Michèle Vogt, Melanie Frank, Norbert Marschner
The aim of this prospective cohort study was to assess current antianemic treatment of cancer patients in German routine practice, including diagnostics, treatments, and quality of life (QoL). 88 study sites recruited 1018 patients at the start of antianemic treatment with hemoglobin (Hb) levels <11 g/dL (females) or <12 g/dL (males). Patients were followed up for 12 weeks. 63% of the patients had inoperable solid tumors, 22% operable solid tumors, and 15% hematological malignancies. Over 85% received chemotherapy...
2016: Anemia
https://www.readbyqxmd.com/read/26865590/impact-of-a-patient-blood-management-program-and-an-outpatient-anemia-management-protocol-on-red-cell-transfusions-in-oncology-inpatients-and-outpatients
#16
Irwin Gross, Kevin M Trentino, Astrid Andreescu, Rhonda Pierson, Richard A Maietta, Shannon Farmer
BACKGROUND: Patient blood management (PBM) programs are associated with reduced transfusion usage, reduced hospital costs, and improved patient outcomes. The application of PBM principles in patients with malignant disease might achieve similar results. However, this population presents unique challenges. The aim of the present study was to investigate the impact of a PBM program on blood usage and patient outcomes in cancer patients, particularly in the setting of restricted use of erythropoiesis-stimulating agents (ESAs)...
March 2016: Oncologist
https://www.readbyqxmd.com/read/26780387/phase-ii-trial-of-docetaxel-bevacizumab-lenalidomide-and-prednisone-in-patients-with-metastatic-castration-resistant-prostate-cancer
#17
Ravi A Madan, Fatima H Karzai, Yang-Min Ning, Bamidele A Adesunloye, Xuan Huang, Nancy Harold, Anna Couvillon, Guinevere Chun, Lisa Cordes, Tristan Sissung, Shaunna L Beedie, Nancy A Dawson, Marc R Theoret, David G McLeod, Inger Rosner, Jane B Trepel, Min-Jung Lee, Yusuke Tomita, Sunmin Lee, Clara Chen, Seth M Steinberg, Philip M Arlen, James L Gulley, William D Figg, William L Dahut
OBJECTIVE: To determine the safety and clinical efficacy of two anti-angiogenic agents, bevacizumab and lenalidomide, with docetaxel and prednisone. PATIENTS AND METHODS: Eligible patients with metastatic castration-resistant prostate cancer enrolled in this open-label, phase II study of lenalidomide with bevacizumab (15 mg/kg), docetaxel (75 mg/m(2) ) and prednisone (10 mg daily). Docetaxel and bevacizumab were administered on day 1 of a 3-week treatment cycle...
October 2016: BJU International
https://www.readbyqxmd.com/read/26700708/thoracic-vertebral-body-irradiation-contributes-to-acute-hematologic-toxicity-during-chemoradiation-therapy-for-non-small-cell-lung-cancer
#18
Matthew P Deek, Brian Benenati, Sinae Kim, Ting Chen, Inaya Ahmed, Wei Zou, Joseph Aisner, Salma K Jabbour
PURPOSE: To determine the relationships between radiation doses to the thoracic bone marrow and declines in blood cell counts in non-small cell lung cancer (NSCLC) patients treated with chemoradiation therapy (CRT). METHODS AND MATERIALS: We included 52 patients with NSCLC treated with definitive concurrent carboplatin-paclitaxel and RT. Dose-volume histogram (DVH) parameters for the thoracic vertebrae (TV), sternum, scapulae, clavicles, and ribs were assessed for associations with changes in blood counts during the course of CRT...
January 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26678853/plasmafiltration-as-a-possible-contributor-to-kinetic-targeting-of-pegylated-liposomal-doxorubicin-pld-in-order-to-prevent-organ-toxicity-and-immunosuppression
#19
Jiřina Martínková, Milan Bláha, Ondřej Kubeček, Jana Maláková, Jiří Špaček, Jan Bezouška, Iva Selke Krulichová, Stanislav Filip
PURPOSE: To examine the removal of pegylated liposomal doxorubicin (PLD) during plasmafiltration (PF) and determine whether the drug could be withheld prior to its organ distribution responsible for mucocutaneous toxicity. METHODS: Six patients suffering from platinum-resistant ovarian cancer were treated with a 1-h IV infusion 50 mg/m(2) of PLD/cycle-for three cycles q4w. Over 44 (46)-47(49) h postinfusion, five patients (14 cycles in total) underwent PF using a cascade PF method consisted of plasma separation by centrifugation and plasma treatment using filtration based one volume of plasma treatment, i...
February 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/26353862/influence-of-age-irradiation-and-humanization-on-nsg-mouse-phenotypes
#20
Jaclyn S Knibbe-Hollinger, Natasha R Fields, Tammy R Chaudoin, Adrian A Epstein, Edward Makarov, Sidra P Akhter, Santhi Gorantla, Stephen J Bonasera, Howard E Gendelman, Larisa Y Poluektova
Humanized mice are frequently utilized in bench to bedside therapeutic tests to combat human infectious, cancerous and degenerative diseases. For the fields of hematology-oncology, regenerative medicine, and infectious diseases, the immune deficient mice have been used commonly in basic research efforts. Obstacles in true translational efforts abound, as the relationship between mouse and human cells in disease pathogenesis and therapeutic studies requires lengthy investigations. The interplay between human immunity and mouse biology proves ever more complicated when aging, irradiation, and human immune reconstitution are considered...
2015: Biology Open
keyword
keyword
57949
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"