keyword
https://read.qxmd.com/read/38536752/causal-functional-maps-of-brain-rhythms-in-working-memory
#1
JOURNAL ARTICLE
Miles Wischnewski, Taylor A Berger, Alexander Opitz, Ivan Alekseichuk
Human working memory is a key cognitive process that engages multiple functional anatomical nodes across the brain. Despite a plethora of correlative neuroimaging evidence regarding the working memory architecture, our understanding of critical hubs causally controlling overall performance is incomplete. Causal interpretation requires cognitive testing following safe, temporal, and controllable neuromodulation of specific functional anatomical nodes. Such experiments became available in healthy humans with the advance of transcranial alternating current stimulation (tACS)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38531217/differences-in-scalp-to-cortex-tissues-across-age-groups-sexes-and-brain-regions-implications-for-neuroimaging-and-brain-stimulation-techniques
#2
JOURNAL ARTICLE
Sybren Van Hoornweder, Marc Geraerts, Stefanie Verstraelen, Marten Nuyts, Kevin A Caulfield, Raf Meesen
Aging affects the scalp-to-cortex distance (SCD) and the comprising tissues. This is crucial for noninvasive neuroimaging and brain stimulation modalities as they rely on traversing from the scalp to the cortex or vice versa. The specific relationship between aging and these tissues has not been comprehensively investigated. We conducted a study on 250 younger and older adults to examine age-related differences in SCD and its constituent tissues. We identified region-specific differences in tissue thicknesses related to age and sex...
February 29, 2024: Neurobiology of Aging
https://read.qxmd.com/read/38520639/comparative-efficacy-of-different-noninvasive-brain-stimulation-protocols-on-upper-extremity-motor-function-and-activities-of-daily-living-after-stroke-a-systematic-review-and-network-meta-analysis
#3
REVIEW
Ling-Ling Li, Jia-Jia Wu, Kun-Peng Li, Jing Jin, Yun-Ting Xiang, Xu-Yun Hua, Mou-Xiong Zheng, Jian-Guang Xu
The objectives of the study were to systematically evaluate the rehabilitation effect of noninvasive brain stimulation (NIBS) on upper extremity motor function and activities of daily living in stroke patients and to prioritize various stimulation protocols for reliable evidence-based medical recommendations in patients with upper extremity motor dysfunction after stroke. Web of Science, PubMed, Embase, Cochrane Library, CNKI, Wanfang, VIP, and CBM were searched to collect all randomized controlled trials (RCTs) of NIBS to improve upper extremity motor function in stroke patients...
March 23, 2024: Neurological Sciences
https://read.qxmd.com/read/38517175/effects-of-accelerated-intermittent-theta-burst-stimulation-in-modulating-brain-of-alzheimer-s-disease
#4
JOURNAL ARTICLE
Hua Lin, Junhua Liang, Qianqian Wang, Yuxuan Shao, Penghui Song, Siran Li, Yang Bai
Intermittent theta-burst stimulation (iTBS) is emerging as a noninvasive therapeutic strategy for Alzheimer's disease (AD). Recent advances highlighted a new accelerated iTBS (aiTBS) protocol, consisting of multiple sessions per day and higher overall pulse doses, in brain modulation. To examine the possibility of applying the aiTBS in treating AD patients, we enrolled 45 patients in AD at early clinical stages, and they were randomly assigned to either receive real or sham aiTBS. Neuropsychological scores were evaluated before and after treatment...
March 1, 2024: Cerebral Cortex
https://read.qxmd.com/read/38514133/-preoperative-simulation-in-epilepsy-surgery
#5
JOURNAL ARTICLE
Kota Kagawa, Koji Iida, Nobutaka Horie
In patients with intractable epilepsy, seizure focus resection can yield favorable seizure outcomes. First, the localization of the seizure focus is estimated by noninvasive methods such as magnetic resonance imaging(MRI), video-electroencephalography(EEG)monitoring, nuclear medicine examinations, magnetoencephalography, and neuropsychological tests. A subgroup of patients may require additional information obtained from the intracranial EEG. There are two major methods for intracranial EEG: intracranial EEG with subdural grid electrodes(SDG)and stereotactic electroencephalography...
March 2024: No Shinkei Geka. Neurological Surgery
https://read.qxmd.com/read/38510947/editorial-neuromuscular-adaptations-to-sensorimotor-stimulation-protocols-potential-rehabilitative-interventions-for-individuals-with-central-or-peripheral-neuromuscular-injuries
#6
EDITORIAL
Jongsang Son, M Hongchul Sohn, Christopher K Thompson
No abstract text is available yet for this article.
2024: Front Rehabil Sci
https://read.qxmd.com/read/38509623/efficacy-of-non-invasive-brain-stimulation-combined-with-antidepressant-medications-for-depression-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
REVIEW
Yuan Tao, Qian Liang, Fenghong Zhang, Shaofan Guo, Lingyun Fan, Fei Zhao
BACKGROUND: Antidepressants, noninvasive brain stimulation (NIBS), and their combination are commonly used in routine clinical practice. Nevertheless, there is a continuous dispute regarding whether the effectiveness of NIBS in combination with antidepressants exceeds that of antidepressants alone. This meta-analysis aimed to evaluate the existing evidence and draw a definitive conclusion on this issue. METHODS: We conducted a comprehensive search of five databases: Embase, PubMed, Web of Science, SinoMed, and the Cochrane Database of Randomized Controlled Trials...
March 20, 2024: Systematic Reviews
https://read.qxmd.com/read/38505983/noninvasive-intervention-by-transcranial-ultrasound-stimulation-modulation-of-neural-circuits-and-its-clinical-perspectives
#8
JOURNAL ARTICLE
Takahiro Osada, Seiki Konishi
Low-intensity focused transcranial ultrasound stimulation (TUS) is an emerging noninvasive technique capable of stimulating both the cerebral cortex and deep brain structures with high spatial precision. This method is recognized for its potential to comprehensively perturb various brain regions, enabling the modulation of neural circuits, in a manner not achievable through conventional magnetic or electrical brain stimulation techniques. The underlying mechanisms of neuromodulation are based on a phenomenon where mechanical waves of ultrasound kinetically interact with neurons, specifically affecting neuronal membranes and mechanosensitive channels...
March 20, 2024: Psychiatry and Clinical Neurosciences
https://read.qxmd.com/read/38500673/no-efficacy-with-noninvasive-brain-stimulation-for-painful-legs-and-moving-toes-a-case-report
#9
Anna Brück, Jaakko Pullinen, Janne Nummelin, Saara Lehto, Juho Joutsa
INTRODUCTION: Painful legs and moving toes (PLMT) is a rare neurological disorder characterized by neuropathic pain and involuntary movements in the lower limbs. The pathophysiological mechanisms are unclear, but central mechanisms might be involved, suggesting that noninvasive brain stimulation might be helpful. Thus far, no reports have been published on noninvasive brain stimulation to treat PLMT. CASE PRESENTATION: A 70-year-old female had a 1-year history of PLMT...
2024: Case Reports in Neurology
https://read.qxmd.com/read/38497620/using-home-based-remotely-supervised-transcranial-direct-current-stimulation-for-phantom-limb-pain
#10
JOURNAL ARTICLE
Kevin Pacheco-Barrios, Daniela Martinez-Magallanes, Cristina Xicota Naqui, Marianna Daibes, Elly Pichardo, Alejandra Cardenas-Rojas, David Crandell, Anahita Dua, Abhishek Datta, Wolnei Caumo, Felipe Fregni
Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that uses low-amplitude direct currents to alter cortical excitability. Previous trials have established the safety and tolerability of tDCS, and its potential to mitigate symptoms. However, the effects are cumulative, making it more difficult to have adherence to the treatment since frequent visits to the clinic or outpatient center are required. Moreover, the time needed for transportation to the center and the related expenses limit the accessibility of the treatment for many participants...
March 1, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38480733/nanobubble-actuated-ultrasound-neuromodulation-for-selectively-shaping-behavior-in-mice
#11
JOURNAL ARTICLE
Xuandi Hou, Jianing Jing, Yizhou Jiang, Xiaohui Huang, Quanxiang Xian, Ting Lei, Jiejun Zhu, Kin Fung Wong, Xinyi Zhao, Min Su, Danni Li, Langzhou Liu, Zhihai Qiu, Lei Sun
Ultrasound is an acoustic wave which can noninvasively penetrate the skull to deep brain regions, enabling neuromodulation. However, conventional ultrasound's spatial resolution is diffraction-limited and low-precision. Here, we report acoustic nanobubble-mediated ultrasound stimulation capable of localizing ultrasound's effects to only the desired brain region in male mice. By varying the delivery site of nanobubbles, ultrasound could activate specific regions of the mouse motor cortex, evoking EMG signaling and limb movement, and could also, separately, activate one of two nearby deep brain regions to elicit distinct behaviors (freezing or rotation)...
March 13, 2024: Nature Communications
https://read.qxmd.com/read/38455067/combined-repetitive-transcranial-magnetic-stimulation-and-gut-microbiota-modulation-through-the-gut-brain-axis-for-prevention-and-treatment-of-autism-spectrum-disorder
#12
REVIEW
Pengya Feng, Yangyang Zhang, Yonghong Zhao, Pengju Zhao, Enyao Li
Autism spectrum disorder (ASD) encompasses a range of neurodevelopmental conditions characterized by enduring impairments in social communication and interaction together with restricted repetitive behaviors, interests, and activities. No targeted pharmacological or physical interventions are currently available for ASD. However, emerging evidence has indicated a potential association between the development of ASD and dysregulation of the gut-brain axis. Repetitive transcranial magnetic stimulation (rTMS), a noninvasive diagnostic and therapeutic approach, has demonstrated positive outcomes in diverse psychiatric disorders; however, its efficacy in treating ASD and its accompanying gastrointestinal effects, particularly the effects on the gut-brain axis, remain unclear...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38452749/effects-of-transcranial-direct-current-stimulation-on-cognitive-function-in-older-adults-with-and-without-mild-cognitive-impairment-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#13
Sijia Li, Ying Tang, You Zhou, Yunxia Ni
INTRODUCTION: Noninvasive brain stimulation (NIBS) has shown benefits for cognitive function in older adults. However, the effects of transcranial direct current stimulation (tDCS) on cognitive function in older adults are inconsistent across studies, and the evidence for tDCS has limitations. We aim to explore whether tDCS can improve cognitive function and different cognitive domains (i.e., learning and memory and executive function) in adults aged 65 and older with and without mild cognitive impairment and to further analyze the influencing factors of tDCS...
March 7, 2024: Gerontology
https://read.qxmd.com/read/38447773/transcranial-focused-ultrasound-of-the-amygdala-modulates-fear-network-activation-and-connectivity
#14
JOURNAL ARTICLE
Tina Chou, Thilo Deckersbach, Bastien Guerin, Karianne Sretavan Wong, Benjamin M Borron, Anish Kanabar, Ashley N Hayden, Marina P Long, Mohammad Daneshzand, Edward F Pace-Schott, Darin D Dougherty
BACKGROUND: Current noninvasive brain stimulation methods are incapable of directly modulating subcortical brain regions critically involved in psychiatric disorders. Transcranial Focused Ultrasound (tFUS) is a newer form of noninvasive stimulation that could modulate the amygdala, a subcortical region implicated in fear. OBJECTIVE: We investigated the effects of active and sham tFUS of the amygdala on fear circuit activation, skin conductance responses (SCR), and self-reported anxiety during a fear-inducing task...
March 4, 2024: Brain Stimulation
https://read.qxmd.com/read/38446899/gamma-entrainment-using-audiovisual-stimuli-alleviates-chemobrain-pathology-and-cognitive-impairment-induced-by-chemotherapy-in-mice
#15
JOURNAL ARTICLE
TaeHyun Kim, Benjamin T James, Martin C Kahn, Cristina Blanco-Duque, Fatema Abdurrob, Md Rezaul Islam, Nicolas S Lavoie, Manolis Kellis, Li-Huei Tsai
Patients with cancer undergoing chemotherapy frequently experience a neurological condition known as chemotherapy-related cognitive impairment, or "chemobrain," which can persist for the remainder of their lives. Despite the growing prevalence of chemobrain, both its underlying mechanisms and treatment strategies remain poorly understood. Recent findings suggest that chemobrain shares several characteristics with neurodegenerative diseases, including chronic neuroinflammation, DNA damage, and synaptic loss...
March 6, 2024: Science Translational Medicine
https://read.qxmd.com/read/38446471/virtual-reality-and-transcranial-direct-current-stimulation-for-posttraumatic-stress-disorder-a-randomized-clinical-trial
#16
JOURNAL ARTICLE
Mascha van 't Wout-Frank, Amanda R Arulpragasam, Christiana Faucher, Emily Aiken, M Tracie Shea, Richard N Jones, Benjamin D Greenberg, Noah S Philip
IMPORTANCE: Posttraumatic stress disorder (PTSD) is a common psychiatric disorder that is particularly difficult to treat in military veterans. Noninvasive brain stimulation has significant potential as a novel treatment to reduce PTSD symptoms. OBJECTIVE: To test whether active transcranial direct current stimulation (tDCS) plus virtual reality (VR) is superior to sham tDCS plus VR for warzone-related PTSD. DESIGN, SETTING, AND PARTICIPANTS: This double-blind randomized clinical trial was conducted among US military veterans enrolled from April 2018 to May 2023 at a secondary care Department of Veterans Affairs hospital and included 1- and 3-month follow-up visits...
March 6, 2024: JAMA Psychiatry
https://read.qxmd.com/read/38444774/effects-of-pain-on-cortical-homeostatic-plasticity-in-humans-a-systematic-review
#17
REVIEW
Daniela M Zolezzi, Dennis B Larsen, Megan McPhee, Thomas Graven-Nielsen
Homeostatic plasticity (HP) is a negative feedback mechanism that prevents excessive facilitation or depression of cortical excitability (CE). Cortical HP responses in humans have been investigated by using 2 blocks of noninvasive brain stimulation with a no-stimulation block in between. A healthy HP response is characterized by reduced CE after 2 excitatory stimulation blocks and increased CE when using inhibitory stimulation. Conversely, impaired HP responses have been demonstrated in experimental and chronic pain conditions...
April 2024: Pain Reports
https://read.qxmd.com/read/38432851/is-it-more-effective-for-anhedonia-and-avolition-a-systematic-review-and-meta-analysis-of-non-invasive-brain-stimulation-interventions-for-negative-symptoms-in-schizophrenia
#18
REVIEW
Yuying Chen, Zhuofeng Li, Chao Yan, Laiquan Zou
BACKGROUND: Noninvasive brain stimulation (NIBS) techniques are a promising tool for treating the negative symptoms of schizophrenia. Growing evidence suggests that different dimensions of negative symptoms have partly distinct underlying pathophysiological mechanisms. Previous randomized controlled trials (RCTs) have shown inconsistent impacts of NIBS across dimensions. OBJECTIVE: This systematic review and meta-analysis evaluated the effects of NIBS on general negative symptoms, and on specific domains, including blunted affect, alogia, asociality, anhedonia, and avolition...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38432828/does-non-invasive-brain-stimulation-improve-spatiotemporal-gait-parameters-in-people-with-multiple-sclerosis-a-systematic-review-and-meta-analysis
#19
REVIEW
Bruno Henrique de Souza Fonseca, Pedro Henrique Sousa de Andrade, Gustavo José Luvizutto
BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease that causes progressive functional impairment, mainly in walking tasks. Noninvasive brain stimulation (NIBS) could influence the motor function and improving gait ability of patients. OBJECTIVE: The aim was to analyze the effects of NIBS (transcranial direct current stimulation [tDCS] or transcranial magnetic stimulation [TMS] on functional locomotion in people with multiple sclerosis (PwMS). METHODS: A search was conducted for randomized controlled trials published up to November 2023 comparing the application of NIBS versus a sham or control group...
January 2024: Journal of Bodywork and Movement Therapies
https://read.qxmd.com/read/38428583/temporally-interfering-electric-fields-brain-stimulation-in-primary-motor-cortex-of-mice-promotes-motor-skill-through-enhancing-neuroplasticity
#20
JOURNAL ARTICLE
Shuo Qi, Xiaodong Liu, Jinglun Yu, Zhiqiang Liang, Yu Liu, Xiaohui Wang
Temporal interference (TI) electric field brain stimulation is a novel neuromodulation technique that enables the non-invasive modulation of deep brain regions, but few advances about TI stimulation effectiveness and mechanisms have been reported. Conventional transcranial alternating current stimulation (tACS) can enhance motor skills, whether TI stimulation has an effect on motor skills in mice has not been elucidated. In the present study, TI stimulation was proved to stimulating noninvasively primary motor cortex (M1) of mice, and that TI stimulation with an envelope wave frequency of 20 Hz (Δ f = 20 Hz) once a day for 20 min for 7 consecutive days significantly improved the motor skills of mice...
February 28, 2024: Brain Stimulation
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