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Noninvasive brain stimulation

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https://www.readbyqxmd.com/read/28715314/optimizing-electric-field-delivery-for-tdcs-virtual-humans-help-to-design-efficient-noninvasive-brain-and-spinal-cord-electrical-stimulation
#1
Pedro C Miranda, Ricardo Salvador, Cornelia Wenger, Sofia R Fernandes
Noninvasive electrical stimulation of the central nervous system is attracting increasing interest from the clinical and academic communities as well as from high-tech companies. This interest was sparked by two landmark studies conducted in 2000 and 2001 at the University of G?ttingen, Germany. Michael Nitsche and Walter Paulus showed that by passing a weak, almost imperceptible electric current between two electrodes on the scalp, they could alter the way the human brain responds to stimuli and that the effect persisted for some time after the current was stopped...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28713248/deep-brain-magnetic-stimulation-promotes-neurogenesis-and-restores-cholinergic-activity-in-a-transgenic-mouse-model-of-alzheimer-s-disease
#2
Junli Zhen, Yanjing Qian, Jian Fu, Ruijun Su, Haiting An, Wei Wang, Yan Zheng, Xiaomin Wang
Alzheimer's disease (AD) is characterized by progressive decline of memory and cognitive functions. Deep magnetic stimulation (DMS), a noninvasive and nonpharmacological brain stimulation, has been reported to alleviate stress-related cognitive impairment in neuropsychiatric disorders. Our previous study also discovered the preventive effect of DMS on cognitive decline in an AD mouse model. However, the underlying mechanism must be explored further. In this study, we investigated the effect of DMS on spatial learning and memory functions, neurogenesis in the dentate gyrus (DG), as well as expression and activity of the cholinergic system in a transgenic mouse model of AD (5XFAD)...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28673806/improved-snr-for-combined-tms-fmri-a-support-device-for-commercially-available-body-array-coil
#3
Wen-Tung Wang, Benjamin Xu, John A Butman
BACKGROUND: Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation tool extensively used in clinical and cognitive neuroscience research. TMS has been applied during functional magnetic resonance imaging (i.e., concurrent/interleaved TMS-fMRI) to understand neural mechanisms underlying cognitive functions. However, no advanced commercial multi-channel whole-brain array MR coils can fit the large TMS coil. We developed a low-cost and easy-to-configure setup that takes advantage of the superior signal-to-noise ratio (SNR) performance of commercially available flexible body array coils that can accommodate the TMS coil...
June 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28659070/noninvasive-stimulation-of-the-human-brain-activation-of-multiple-cortical-circuits
#4
Vincenzo Di Lazzaro, John Rothwell, Marco Capogna
Noninvasive brain stimulation methods, such as transcranial electric stimulation and transcranial magnetic stimulation are widely used tools for both basic research and clinical applications. However, the cortical circuits underlying their effects are poorly defined. Here we review the current knowledge based on data mostly coming from experiments performed on human subjects, and also to a lesser extent on rodent or primate models. The data suggest that multiple mechanisms are likely to be involved, such as the direct activation of layer V pyramidal neurons, but also of different types of GABAergic interneurons...
June 1, 2017: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/28657865/noninvasive-brain-stimulation-for-depression-the-devil-is-in-the-dosing
#5
COMMENT
Sarah H Lisanby
New England Journal of Medicine, Volume 376, Issue 26, Page 2593-2594, June 2017.
June 29, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28647001/gastric-bypass-surgery-stimulates-the-dormant-gut-brain-axis-in-obesity
#6
Stephanie P B Caligiuri, Paul J Kenny
To truly reduce the rates of chronic kidney disease, a root cause of kidney damage, obesity, must be targeted. Weight loss is often unsustainable because imbalances in satiety regulators are frequently not addressed to ensure maintenance of weight loss. In a recent study, gastric bypass surgery rebalanced satiety signals through resensitization of the gut-brain axis in obesity. This research may lead to noninvasive strategies to reduce obesity and obesity-related kidney disease.
July 2017: Kidney International
https://www.readbyqxmd.com/read/28638327/noninvasive-brain-stimulation-and-personal-identity-ethical-considerations
#7
Jonathan Iwry, David B Yaden, Andrew B Newberg
As noninvasive brain stimulation (NIBS) technology advances, these methods may become increasingly capable of influencing complex networks of mental functioning. We suggest that these might include cognitive and affective processes underlying personality and belief systems, which would raise important questions concerning personal identity and autonomy. We give particular attention to the relationship between personal identity and belief, emphasizing the importance of respecting users' personal values. We posit that research participants and patients should be encouraged to take an active approach to considering the personal implications of altering their own cognition, particularly in cases of neurocognitive "enhancement...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28637840/promoting-sleep-oscillations-and-their-functional-coupling-by-transcranial-stimulation-enhances-memory-consolidation-in-mild-cognitive-impairment
#8
Julia Ladenbauer, Josef Ladenbauer, Nadine Külzow, Rebecca de Boor, Elena Avramova, Ulrike Grittner, Agnes Flöel
Alzheimer's disease (AD) not only involves loss of memory functions but also prominent deterioration of sleep physiology, already evident in the stage of mild cognitive impairment (MCI). Cortical slow oscillations (SO, 0.5-1 Hz) and thalamo-cortical spindle activity (12-15 Hz) during sleep, and their temporal coordination, are considered critical for memory formation. We investigated the potential of slow oscillatory transcranial direct current stimulation (so-tDCS), applied during a daytime nap in a sleep state-dependent manner, to modulate these activity patterns and sleep-related memory consolidation in 9 male and 7 female human patients with MCI...
June 21, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28632508/combined-dextroamphetamine-and-transcranial-direct-current-stimulation-in-poststroke-aphasia
#9
Zafer Keser, Michelle Weber Dehgan, Shaparak Shadravan, Nuray Yozbatiran, Lynn M Maher, Gerard E Francisco
There is a growing need for various effective adjunctive treatment options for speech recovery after stroke. A pharmacological agent combined with noninvasive brain stimulation has not been previously reported for poststroke aphasia recovery. In this "proof of concept" study, we aimed to test the safety of a combined intervention consisting of dextroamphetamine, transcranial direct current stimulation, and speech and language therapy in subjects with nonfluent aphasia. Ten subjects with chronic nonfluent aphasia underwent two experiments where they received dextroamphetamine or placebo along with transcranial direct current stimulation and speech and language therapy on two separate days...
June 20, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28629225/cortical-plasticity-in-depression
#10
Mariagiovanna Cantone, Alessia Bramanti, Giuseppe Lanza, Manuela Pennisi, Placido Bramanti, Giovanni Pennisi, Rita Bella
Neural plasticity is considered the neurophysiological correlate of learning and memory, although several studies have also noted that it plays crucial roles in a number of neurological and psychiatric diseases. Indeed, impaired brain plasticity may be one of the pathophysiological mechanisms that underlies both cognitive decline and major depression. Moreover, a degree of cognitive impairment is frequently observed throughout the clinical spectrum of mood disorders, and the relationship between depression and cognition is often bidirectional...
May 2017: ASN Neuro
https://www.readbyqxmd.com/read/28628538/memory-rehabilitation-strategies-in-nonsurgical-temporal-lobe-epilepsy-a-review
#11
Alessandra Del Felice, Marzia Alderighi, Matteo Martinato, Davide Grisafi, Anna Bosco, Pamela J Thompson, Josemir W Sander, Stefano Masiero
People with temporal lobe epilepsy (TLE) who have not undergone epilepsy surgery often complain of memory deficits. Cognitive rehabilitation is employed as a remedial intervention in clinical settings, but research is limited and findings concerning efficacy and the criteria for choosing different approaches have been inconsistent. We aimed to appraise existing evidence on memory rehabilitation in nonsurgical individuals with temporal lobe epilepsy and to ascertain the effectiveness of specific strategies. A scoping review was preferred given the heterogeneous nature of the interventions...
July 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28627790/regional-cerebral-blood-flow-in-opiate-dependence-relates-to-substance-use-and-neuropsychological-performance
#12
Donna E Murray, Timothy C Durazzo, Thomas P Schmidt, Troy A Murray, Christoph Abé, Joseph Guydish, Dieter J Meyerhoff
Neuroimaging of opiate-dependent individuals indicates both altered brain structure and function. Magnetic resonance-based arterial spin labeling has been used to measure noninvasively cerebral blood flow (i.e. perfusion) in alcohol, tobacco and stimulant dependence; only one arterial spin labeling paper in opiate-dependent individuals demonstrated frontal and parietal perfusion deficits. Additional research on regional brain perfusion in opiate dependence and its relationship to cognition and self-regulation (impulsivity, risk taking and decision making) may inform treatment approaches for opiate-dependent individuals...
June 19, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28615985/treatment-of-movement-disorders-with-focused-ultrasound
#13
REVIEW
Paul S Fishman, Victor Frenkel
Although the use of ultrasound as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists or neurologists are familiar with this technology. Stereotactic brain lesioning had been widely used as a treatment for medically refractory patients with essential tremor (ET), Parkinson disease (PD), and dystonia but has been largely replaced by deep brain stimulation (DBS) surgery, with advantages both in safety and efficacy. However, DBS is associated with complications including intracerebral hemorrhage, infection, and hardware malfunction...
2017: Journal of Central Nervous System Disease
https://www.readbyqxmd.com/read/28607750/noninvasive-tongue-stimulation-combined-with-intensive-cognitive-and-physical-rehabilitation-induces-neuroplastic-changes-in-patients-with-multiple-sclerosis-a-multimodal-neuroimaging-study
#14
Gabriel Leonard, Yves Lapierre, Jen-Kai Chen, Rima Wardini, Joelle Crane, Alain Ptito
BACKGROUND: Multiple sclerosis (MS) patients have central nervous system (CNS) lesions that may impede cognitive and sensorimotor function. Few rehabilitative therapies are available. OBJECTIVES: The objective of this paper is to study effects of noninvasive tongue stimulation using the Portable Neuromodulation Stimulator (PoNS™) combined with intensive cognitive and physical rehabilitation on working memory, gait, balance and concomitant changes in the brain...
January 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28605386/simultaneous-transcranial-alternating-current-stimulation-and-functional-magnetic-resonance-imaging
#15
Kathleen A Williams, Yuranny Cabral-Calderin, Carsten Schmidt-Samoa, Christiane Anne Weinrich, Peter Dechent, Melanie Wilke
Transcranial alternating current stimulation (tACS) is a promising tool for noninvasive investigation of brain oscillations. TACS employs frequency-specific stimulation of the human brain through current applied to the scalp with surface electrodes. Most current knowledge of the technique is based on behavioral studies; thus, combining the method with brain imaging holds potential to better understand the mechanisms of tACS. Because of electrical and susceptibility artifacts, combining tACS with brain imaging can be challenging, however, one brain imaging technique that is well suited to be applied simultaneously with tACS is functional magnetic resonance imaging (fMRI)...
June 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28597028/-aphasia-a%C3%A2-neuronal-network-disorder
#16
REVIEW
A Stockert, D Saur
Language processing requires the coordinated interaction of local and distant neural populations within distributed networks of the temporal, frontal and parietal brain regions. Poststroke aphasia is the consequence of both local as well as remote dysfunction within language-specific and domain-general networks. Language recovery, in turn, rests on reorganization processes within these networks. These comprise the resolution of an acute network failure (i. e. diaschisis), the subacute activation of right hemisphere homologous regions and the gradual reintegration of left hemisphere remote and perilesional areas...
June 8, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28583011/cognitive-training-and-noninvasive-brain-stimulation-for-cognition-in-parkinson-s-disease-a-meta-analysis
#17
Blake J Lawrence, Natalie Gasson, Romola S Bucks, Lakkhina Troeung, Andrea M Loftus
BACKGROUND: Many people with Parkinson's disease (PD) experience cognitive decline. It is not known whether cognitive training or noninvasive brain stimulation are effective at alleviating cognitive deficits in PD. OBJECTIVE: To examine cognitive training and non-invasive brain stimulation interventions for cognition in PD. METHODS: An extensive search was conducted of published and unpublished studies in online databases. Studies were selected if they were controlled trials examining standard (not individualized) or tailored (individualized) cognitive training, repetitive transcranial magnetic stimulation (rTMS), or transcranial direct current stimulation (tDCS) in PD, with outcomes measured by standardized neuropsychological tests...
July 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28575675/noninvasive-neuromodulation-goes-deep
#18
Jacek Dmochowski, Marom Bikson
Modulating deep regions of the brain with noninvasive technology has challenged researchers for decades. In a new study, Grossman et al. leverage the emergence of a slowly oscillating "beat" from intersecting high-frequency electric fields to stimulate deep brain regions, opening a frontier in the biophysics and technology of brain stimulation.
June 1, 2017: Cell
https://www.readbyqxmd.com/read/28575667/noninvasive-deep-brain-stimulation-via-temporally-interfering-electric-fields
#19
Nir Grossman, David Bono, Nina Dedic, Suhasa B Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, Edward S Boyden
We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope...
June 1, 2017: Cell
https://www.readbyqxmd.com/read/28571401/a-novel-signal-acquisition-platform-of-human-cardiovascular-information-with-noninvasive-method
#20
Longcong Chen, Shaoxi Cai, Bo Li, Qifeng Jiang, Ming Ke, Yi Zhao, Sijia Chen, Misha Zou
Cardiovascular diseases (CVDs) are considered the major cause of death worldwide, so more researchers pay more and more attention to the development of a non-invasive method to obtain as much cardiovascular information (CVI) as possible for early screening and diagnosing. It is known that considerable brain information could be probed by a variety of stimuli (such as video, light, and sound). Therefore, it is quite possible that much more CVI could be extracted via giving the human body some special interrelated stimulus...
May 2017: Review of Scientific Instruments
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