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Resting state functional connectivity

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https://www.readbyqxmd.com/read/28944718/obesity-is-associated-with-altered-mid-insula-functional-connectivity-to-limbic-regions-underlying-appetitive-responses-to-foods
#1
Jason A Avery, Joshua N Powell, Florence J Breslin, Rebecca J Lepping, Laura E Martin, Trisha M Patrician, Joseph E Donnelly, Cary R Savage, W Kyle Simmons
Obesity is fundamentally a disorder of energy balance. In obese individuals, more energy is consumed than is expended, leading to excessive weight gain through the accumulation of adipose tissue. Complications arising from obesity, including cardiovascular disease, elevated peripheral inflammation, and the development of Type II diabetes, make obesity one of the leading preventable causes of morbidity and mortality. Thus, it is of paramount importance to both individual and public health that we understand the neural circuitry underlying the behavioral regulation of energy balance...
September 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28944305/network-organization-is-globally-atypical-in-autism-a-graph-theory-study-of-intrinsic-functional-connectivity
#2
Christopher L Keown, Michael C Datko, Colleen P Chen, José Omar Maximo, Afrooz Jahedi, Ralph-Axel Müller
BACKGROUND: Despite abundant evidence of brain network anomalies in autism spectrum disorder (ASD), findings have varied from broad functional underconnectivity to broad overconnectivity. Rather than pursuing overly simplifying general hypotheses ('under' vs. 'over'), we tested the hypothesis of atypical network distribution in ASD (i.e., participation of unusual loci in distributed functional networks). METHODS: We used a selective high-quality data subset from the ABIDE datashare (including 111 ASD and 174 typically developing [TD] participants) and several graph theory metrics...
January 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28943848/multimodal-discrimination-of-schizophrenia-using-hybrid-weighted-feature-concatenation-of-brain-functional-connectivity-and-anatomical-features-with-an-extreme-learning-machine
#3
Muhammad Naveed Iqbal Qureshi, Jooyoung Oh, Dongrae Cho, Hang Joon Jo, Boreom Lee
Multimodal features of structural and functional magnetic resonance imaging (MRI) of the human brain can assist in the diagnosis of schizophrenia. We performed a classification study on age, sex, and handedness-matched subjects. The dataset we used is publicly available from the Center for Biomedical Research Excellence (COBRE) and it consists of two groups: patients with schizophrenia and healthy controls. We performed an independent component analysis and calculated global averaged functional connectivity-based features from the resting-state functional MRI data for all the cortical and subcortical anatomical parcellation...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28943835/investigating-brain-connectomic-alterations-in-autism-using-the-reproducibility-of-independent-components-derived-from-resting-state-functional-mri-data
#4
Mohammed A Syed, Zhi Yang, Xiaoping P Hu, Gopikrishna Deshpande
Significance: Autism is a developmental disorder that is currently diagnosed using behavioral tests which can be subjective. Consequently, objective non-invasive imaging biomarkers of Autism are being actively researched. The common theme emerging from previous functional magnetic resonance imaging (fMRI) studies is that Autism is characterized by alterations of fMRI-derived functional connections in certain brain networks which may provide a biomarker for objective diagnosis. However, identification of individuals with Autism solely based on these measures has not been reliable, especially when larger sample sizes are taken into consideration...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28942738/childhood-stress-grown-up-brain-networks-corticolimbic-correlates-of-threat-related-early-life-stress-and-adult-stress-response
#5
R H Kaiser, R Clegg, F Goer, P Pechtel, M Beltzer, G Vitaliano, D P Olson, M H Teicher, D A Pizzagalli
BACKGROUND: Exposure to threat-related early life stress (ELS) has been related to vulnerability for stress-related disorders in adulthood, putatively via disrupted corticolimbic circuits involved in stress response and regulation. However, previous research on ELS has not examined both the intrinsic strength and flexibility of corticolimbic circuits, which may be particularly important for adaptive stress responding, or associations between these dimensions of corticolimbic dysfunction and acute stress response in adulthood...
September 25, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28942672/integration-and-segregation-of-default-mode-network-resting-state-functional-connectivity-in-transition-age-males-with-high-functioning-autism-spectrum-disorder-a-proof-of-concept-study
#6
Gagan Joshi, Sheeba Arnold Anteraper, Kaustubh Patil, Meha Semwal, Rachel Goldin, Stephannie Furtak, Xiaoqian Jenny Chai, Zeynep Saygin, John D Gabrieli, Joseph Biederman, Susan Whitfield-Gabrieli
OBJECTIVES: To assess the resting-state functional connectivity (RsFc) profile of the default mode network (DMN) in transition-age males with autism spectrum disorder (ASD). METHODS: Resting-state blood oxygen level dependent functional MRI (fMRI) data were acquired from adolescent and young adult males with high-functioning ASD (N=15) and from age-, sex-, and IQ-matched healthy controls (HC; N=16). The DMN was examined by assessing the positive and negative RsFc correlations of an average of the literature-based conceptualized major DMN nodes (medial prefrontal cortex [mPFC], posterior cingulate cortex, bilateral angular and inferior temporal gyrii regions)...
September 24, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28942477/cognitive-performance-in-mid-stage-parkinson-s-disease-functional-connectivity-under-chronic-antiparkinson-treatment
#7
Roxana Vancea, Kristina Simonyan, Maria Petracca, Miroslaw Brys, Alessandro Di Rocco, Maria Felice Ghilardi, Matilde Inglese
Cognitive impairment in Parkinson's disease (PD) is related to the reorganization of brain topology. Although drug challenge studies have proven how levodopa treatment can modulate functional connectivity in brain circuits, the role of chronic dopaminergic therapy on cognitive status and functional connectivity has never been investigated. We sought to characterize brain functional topology in mid-stage PD patients under chronic antiparkinson treatment and explore the presence of correlation between reorganization of brain architecture and specific cognitive deficits...
September 23, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28942061/the-behavioral-and-cognitive-relevance-of-time-varying-dynamic-changes-in-functional-connectivity
#8
REVIEW
Jessica R Cohen
Recent advances in neuroimaging methods and analysis have led to an expanding body of research that investigates how large-scale brain network organization dynamically adapts to changes in one's environment, including both internal state changes and external stimulation. It is now possible to detect changes in functional connectivity that occur on the order of seconds, both during an unconstrained resting state and during the performance of constrained cognitive tasks. It is thought that these dynamic, time-varying changes in functional connectivity, often referred to as dynamic functional connectivity (dFC), include features that are relevant to behavior and cognition...
September 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28942060/functional-networks-and-network-perturbations-in-rodents
#9
REVIEW
Kai-Hsiang Chuang, Fatima A Nasrallah
Synchronous low-frequency oscillation in the resting human brain has been found to form networks of functionally associated areas and hence has been widely used to map the functional connectivity of the brain using techniques such as resting-state functional MRI (rsfMRI). Interestingly, similar resting-state networks can also be detected in the anesthetized rodent brain, including the default mode-like network. This opens up opportunities for understanding the neurophysiological basis of the rsfMRI signal, the behavioral relevance of the network characteristics, connectomic deficits in diseases and treatment effects on brain connectivity using rodents, particularly transgenic mouse models...
September 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28941768/lateralization-effects-on-functional-connectivity-of-the-auditory-network-in-patients-with-unilateral-pulsatile-tinnitus-as-detected-by-functional-mri
#10
Han Lv, Pengfei Zhao, Zhaohui Liu, Xuehuan Liu, Heyu Ding, Liheng Liu, Guopeng Wang, Jing Xie, Rong Zeng, Yuchen Chen, Zhenghan Yang, Shusheng Gong, Zhenchang Wang
Unilateral pulsatile tinnitus (PT) was proved to be a kind of disease with brain functional abnormalities within and beyond the auditory network (AN). However, changes in patterns of the lateralization effects of PT are yet to be established. Relationship between the AN and other brain networks in PT patients is also a scientific question need to be answered. In this study, we recruited 23 left-sided, 23 right-sided PT (LSPT, RSPT) patients and 23 normal controls (NC). We combined applied independent component analysis and seed-based functional connectivity (FC) analysis to investigate alteration feature of the FC of the AN by using resting-state functional magnetic resonance imaging (rs-fMRI)...
September 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28940855/long-term-effects-of-cognitive-rehabilitation-on-brain-functional-outcome-and-cognition-in-parkinson-s-disease
#11
María Díez-Cirarda, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, Olaia Lucas-Jiménez, Juan Carlos Gómez-Esteban, Maria Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
BACKGROUND: Cognitive rehabilitation has demonstrated efficacy in producing short-term cognitive and brain changes in Parkinson's disease (PD) patients. To date, no study has assessed the long-term effects of cognitive rehabilitation using neuroimaging techniques in PD. The aim was to assess the longitudinal effects of a 3-month cognitive rehabilitation program evaluating the cognitive, behavioural and neuroimaging changes after 18 months. METHODS: Fifteen PD patients underwent a cognitive, behavioural and neuroimaging assessment at pre-treatment (T0 ), post-treatment (T1 ) and after 18-months (T2 )...
September 23, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28940312/increased-thalamic-resting-state-connectivity-as-a-core-driver-of-lsd-induced-hallucinations
#12
F Müller, C Lenz, P Dolder, U Lang, A Schmidt, M Liechti, S Borgwardt
OBJECTIVE: It has been proposed that the thalamocortical system is an important site of action of hallucinogenic drugs and an essential component of the neural correlates of consciousness. Hallucinogenic drugs such as LSD can be used to induce profoundly altered states of consciousness, and it is thus of interest to test the effects of these drugs on this system. METHOD: 100 μg LSD was administrated orally to 20 healthy participants prior to fMRI assessment. Whole brain thalamic functional connectivity was measured using ROI-to-ROI and ROI-to-voxel approaches...
September 21, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28939939/cognitive-performance-change-of-pediatric-patients-after-conducting-frontal-transcortical-approach-to-treat-lateral-ventricular-tumor
#13
Wanchun Zhu, Jintao He, Xiang Li, Lei Wang, Zheng Lu, Chunde Li, Jian Gong
OBJECTIVE: Applying frontal transcortical approach to treat lateral ventricular tumor is one of the most common neurosurgical manipulations. The frontal transcortical approach generally passes through the middle frontal gyrus in which there is no major function involved in the traditional sense. However, current researches have suggested that the prefrontal cortex (PFC) plays a central role in the whole network of the brain cognitive frame. In addition, cognitive function is crucial in growing and developmental stages and essential for the educational achievement, especially for children...
September 22, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28939804/separate-neural-representations-of-depression-anxiety-and-apathy-in-parkinson-s-disease
#14
Rotem Dan, Filip Růžička, Ondrej Bezdicek, Evžen Růžička, Jan Roth, Josef Vymazal, Gadi Goelman, Robert Jech
Depression, anxiety and apathy are distinct neuropsychiatric symptoms that highly overlap in Parkinson's disease (PD). It remains unknown whether each symptom is uniquely associated with a functional network dysfunction. Here, we examined whether individual differences in each neuropsychiatric symptom predict functional connectivity patterns in PD patients while controlling for all other symptoms and motor function. Resting-state functional connectivity MRI were acquired from 27 PD patients and 29 healthy controls...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28939432/characterizing-dynamic-amplitude-of-low-frequency-fluctuation-and-its-relationship-with-dynamic-functional-connectivity-an-application-to-schizophrenia
#15
REVIEW
Zening Fu, Yiheng Tu, Xin Di, Yuhui Du, G D Pearlson, J A Turner, Bharat B Biswal, Zhiguo Zhang, V D Calhoun
The human brain is a highly dynamic system with non-stationary neural activity and rapidly-changing neural interaction. Resting-state dynamic functional connectivity (dFC) has been widely studied during recent years, and the emerging aberrant dFC patterns have been identified as important features of many mental disorders such as schizophrenia (SZ). However, only focusing on the time-varying patterns in FC is not enough, since the local neural activity itself (in contrast to the inter-connectivity) is also found to be highly fluctuating from research using high-temporal-resolution imaging techniques...
September 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28938855/eeg-resting-state-networks-microstates-source-localization
#16
Anna Custo, Dimitri van der Ville, William M Wells, Ioana M Tomescu, Christoph Michel
Using EEG to elucidate the spontaneous activation of brain resting state networks is non trivial as the signal of interest is of low amplitude and it is difficult to distinguish the underlying neural sources. Using the principles of electric field topographical analysis, it is possible to estimate the meta-stable states of the brain (i.e., the resting state topographies, so-called microstates). We estimated seven resting state topographies explaining the EEG dataset with k-means clustering (N=164, 256 electrodes)...
September 22, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28938222/inter-hemispherical-asymmetry-in-default-mode-functional-connectivity-and-baiap2-gene-are-associated-with-anger-expression-in-adhd-adults
#17
R Hasler, M G Preti, D E Meskaldji, J Prados, W Adouan, C Rodriguez, S Toma, N Hiller, T Ismaili, J Hofmeister, I Sinanaj, P Baud, S Haller, P Giannakopoulos, S Schwartz, N Perroud, D Van De Ville
Attention deficit hyperactivity disorder (ADHD) is accompanied by resting-state alterations, including abnormal activity, connectivity and asymmetry of the default-mode network (DMN). Concurrently, recent studies suggested a link between ADHD and the presence of polymorphisms within the gene BAIAP2 (i.e., brain-specific angiogenesis inhibitor 1-associated protein 2), known to be differentially expressed in brain hemispheres. The clinical and neuroimaging correlates of this polymorphism are still unknown. We investigated the association between BAIAP2 polymorphisms and DMN functional connectivity (FC) asymmetry as well as behavioral measures in ADHD adults...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28936168/mining-time-resolved-functional-brain-graphs-to-an-eeg-based-chronnectomic-brain-aged-index-cbai
#18
Stavros I Dimitriadis, Christos I Salis
The brain at rest consists of spatially and temporal distributed but functionally connected regions that called intrinsic connectivity networks (ICNs). Resting state electroencephalography (rs-EEG) is a way to characterize brain networks without confounds associated with task EEG such as task difficulty and performance. A novel framework of how to study dynamic functional connectivity under the notion of functional connectivity microstates (FCμstates) and symbolic dynamics is further discussed. Furthermore, we introduced a way to construct a single integrated dynamic functional connectivity graph (IDFCG) that preserves both the strength of the connections between every pair of sensors but also the type of dominant intrinsic coupling modes (DICM)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28933314/effectiveness-of-a-low-support-remotely-accessible-cognitive-remediation-training-programme-for-chronic-psychosis-cognitive-functional-and-cortical-outcomes-from-a-single-blind-randomised-controlled-trial
#19
G Donohoe, R Dillon, A Hargreaves, O Mothersill, M Castorina, E Furey, A J Fagan, J F Meaney, B Fitzmaurice, B Hallahan, C McDonald, T Wykes, A Corvin, I H Robertson
BACKGROUND: Cognitive remediation (CR) training has emerged as a promising approach to improving cognitive deficits in schizophrenia and related psychosis. The limited availability of psychological services for psychosis is a major barrier to accessing this intervention however. This study investigated the effectiveness of a low support, remotely accessible, computerised working memory (WM) training programme in patients with psychosis. METHODS: Ninety patients were enrolled into a single blind randomised controlled trial of CR...
September 21, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28927378/genome-wide-imaging-association-study-implicates-functional-activity-and-glial-homeostasis-of-the-caudate-in-smoking-addiction
#20
David C Qian, David L Molfese, Jennifer L Jin, Alexander J Titus, Yixuan He, Yafang Li, Maxime Vaissié, Humsini Viswanath, Philip R Baldwin, Ralf Krahe, Ramiro Salas, Christopher I Amos
BACKGROUND: Nearly 6 million deaths and over a half trillion dollars in healthcare costs worldwide are attributed to tobacco smoking each year. Extensive research efforts have been pursued to elucidate the molecular underpinnings of smoking addiction and facilitate cessation. In this study, we genotyped and obtained both resting state and task-based functional magnetic resonance imaging from 64 non-smokers and 42 smokers. Smokers were imaged after having smoked normally ("sated") and after having not smoked for at least 12 h ("abstinent")...
September 19, 2017: BMC Genomics
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