keyword
https://read.qxmd.com/read/38361991/innovative-cellular-therapies-for-autoimmune-diseases-expert-based-position-statement-and-clinical-practice-recommendations-from-the-ebmt-practice-harmonization-and-guidelines-committee
#21
REVIEW
Raffaella Greco, Tobias Alexander, Nicoletta Del Papa, Fabian Müller, Riccardo Saccardi, Fermin Sanchez-Guijo, Georg Schett, Basil Sharrack, John A Snowden, Karin Tarte, Francesco Onida, Isabel Sánchez-Ortega, Joachim Burman, Cristina Castilla Llorente, Ricard Cervera, Fabio Ciceri, Andrea Doria, Jörg Henes, James Lindsay, Andreas Mackensen, Paolo A Muraro, Elena Ricart, Montserrat Rovira, Tsila Zuckerman, Ibrahim Yakoub-Agha, Dominique Farge
Autoimmune diseases (ADs) are characterized by loss of immune tolerance, high chronicity, with substantial morbidity and mortality, despite conventional immunosuppression (IS) or targeted disease modifying therapies (DMTs), which usually require repeated administration. Recently, novel cellular therapies (CT), including mesenchymal stromal cells (MSC), Chimeric Antigen Receptors T cells (CART) and regulatory T cells (Tregs), have been successfully adopted in ADs. An international expert panel of the European Society for Blood and Marrow Transplantation and the International Society for the Cell and Gene Therapy, reviewed all available evidence, based on the current literature and expert practices, on use of MSC, CART and Tregs, in AD patients with rheumatological, neurological, and gastroenterological indications...
March 2024: EClinicalMedicine
https://read.qxmd.com/read/38358270/retrospective-case-series-of-spinal-cord-neurapraxia-in-male-adolescent-athletes-can-these-athletes-return-to-play
#22
JOURNAL ARTICLE
Jacob Jo, Trevor J Anesi, E Haley Vance, Allen K Sills, Scott L Zuckerman, Christopher M Bonfield
BACKGROUND AND OBJECTIVES: While spinal cord neurapraxia (SCN) is a documented pathology in athletes, guidance for neurosurgeons evaluating these patients is sparse. Therefore, in a cohort of adolescent athletes with SCN, we sought to (1) review their presentation and management and (2) describe outcomes and return-to-play (RTP). METHODS: A single-center, retrospective case series was conducted to examine adolescent athletes diagnosed with SCN from 2017 to 2022...
February 15, 2024: Neurosurgery
https://read.qxmd.com/read/38353685/clinical-compatibility-of-magnetic-resonance-imaging-with-magnetic-intramedullary-nails-a-feasibility-study
#23
JOURNAL ARTICLE
Joseph D Femino, Samuel R Barnes, Scott C Nelson, Lee M Zuckerman
INTRODUCTION: The use of magnetic resonance imaging (MRI) with a magnetic intramedullary lengthening nail in place is contraindicated per the manufacturer due to the concern of implant activation and migration. A prior in vitro study did not confirm these complications only noting that a 3.0 T MRI weakened the internal magnet. Therefore, a retrospective analysis of patients who underwent an MRI with a magnetic nail in place was performed to determine if any adverse effects occurred in the clinical setting...
February 14, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38352722/pharmacist-review-of-chronic-inhaler-therapy-appropriateness-for-hospitalized-patients-with-copd-or-asthma
#24
JOURNAL ARTICLE
Tate D Parrott, Matthew D Wallace, Kristina M Niehoff, Sarah H Eble, Lauren Blumenfeld, Carla M Sevin, Neesha N Choma, Yue Gao, Leena Choi, Christopher J Lindsell, Autumn D Zuckerman
INTRODUCTION: Patients with asthma and chronic obstructive pulmonary disease rely on inhaler therapy to reduce disease progression and exacerbation risk. Patients admitted to the hospital are at an increased risk for exacerbations and readmission if their inhaler therapy upon discharge is not aligned with current guidelines and/or affordable. OBJECTIVE: Assess the appropriateness of the chronic inhaler regimen for patients admitted to the hospital based on clinical practice guidelines and insurance coverage...
December 2023: Journal of the American College of Clinical Pharmacy: JAACP
https://read.qxmd.com/read/38337376/combined-anterior-posterior-vs-posterior-only-approach-in-adult-spinal-deformity-surgery-which-strategy-is-superior
#25
JOURNAL ARTICLE
Iyan Younus, Hani Chanbour, Jeffrey W Chen, Graham W Johnson, Tyler Metcalf, Alexander T Lyons, Soren Jonzzon, Campbell Liles, Steven G Roth, Amir M Abtahi, Byron F Stephens, Scott L Zuckerman
Introduction: Whether a combined anterior-posterior (AP) approach offers additional benefits over the posterior-only (P) approach in adult spinal deformity (ASD) surgery remains unknown. In a cohort of patients undergoing ASD surgery, we compared the combined AP vs. the P-only approach in: (1) preoperative/perioperative variables, (2) radiographic measurements, and (3) postoperative outcomes. Methods: A single-institution, retrospective cohort study was performed for patients undergoing ASD surgery from 2009 to 2021...
January 24, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38336441/unusual-cause-of-hemoptysis-in-a-woman-with-cystic-fibrosis
#26
John W Gilboy, D O'Brien, J B Zuckerman
A 20-year-old patient with cystic fibrosis (CF) complicated by pansinusitis, pancreatic insufficiency, and diabetes presented to the local ED after an episode of large-volume hemoptysis at home. At baseline, she had advanced lung disease (FEV1 , 0.97 L; 31% predicted) and upper lobe-predominant fibrocavitary changes. She was intermittently followed at a regional lung transplant center. She was previously evaluated for transplant but was not listed at the time of this presentation because of nontuberculous mycobacteria infection...
February 2024: Chest
https://read.qxmd.com/read/38335326/symptom-resolution-following-a-repeat-concussion-within-the-same-athlete
#27
JOURNAL ARTICLE
Alan R Tang, Kristen L Williams, Philip J Davis, Alan Z Grusky, Brian Q Hou, Katherine S Hajdu, Aaron M Yengo-Kahn, Scott L Zuckerman, Douglas P Terry
INTRODUCTION: Repeat sport-related concussion (SRC) is anecdotally associated with prolonged recovery. Few studies have examined repeat concussion within the same athlete. We sought to explore differences in symptom burden and recovery outcomes in an individual athlete's initial and repeat SRC. METHODS: A retrospective within-subject cohort study of athletes aged 12-23 years diagnosed with two separate SRCs from 11/2017-10/2020 was conducted. Primary outcomes were initial symptom severity and time-to-symptom-resolution...
February 9, 2024: Brain Injury
https://read.qxmd.com/read/38318079/enhancing-eeg-based-attachment-style-prediction-unveiling-the-impact-of-feature-domains
#28
JOURNAL ARTICLE
Ilan Laufer, Dor Mizrahi, Inon Zuckerman
INTRODUCTION: Attachment styles are crucial in human relationships and have been explored through neurophysiological responses and EEG data analysis. This study investigates the potential of EEG data in predicting and differentiating secure and insecure attachment styles, contributing to the understanding of the neural basis of interpersonal dynamics. METHODS: We engaged 27 participants in our study, employing an XGBoost classifier to analyze EEG data across various feature domains, including time-domain, complexity-based, and frequency-based attributes...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38316238/impact-of-accumulating-risk-factors-on-the-incidence-of-dislocation-after-primary-reverse-total-shoulder-arthroplasty-using-a-medial-glenoid-lateral-humerus-onlay-prosthesis
#29
JOURNAL ARTICLE
Moby Parsons, Josie Elwell, Stephanie Muh, Thomas Wright, Pierre Flurin, Joseph Zuckerman, Christopher Roche
INTRODUCTION: The aim of this study is to facilitate preoperative identification of patients at-risk for dislocation after reverse total shoulder arthroplasty (rTSA) using the Equinoxe rTSA prosthesis (medialized glenoid, lateralized onlay humerus with a 145° neck angle) and quantify the impact of accumulating risk factors on the occurrence of dislocation. METHODS: We retrospectively analyzed 10,023 primary rTSA patients from an international multi-center database of a single platform shoulder prosthesis and quantified the dislocation rate associated with multiple combinations of previously identified risk factors...
February 3, 2024: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/38312300/two-year-minimum-survivorship-and-radiographic-analysis-of-a-pressfit-short-humeral-stem-for-total-shoulder-arthroplasty
#30
JOURNAL ARTICLE
Gabriel Larose, William R Aibinder, Alexander T Greene, Christopher P Roche, Sean Grey, Kenneth J Faber, Howard Routman, Samuel Antuña, Thomas Wright, Pierre-Henri Flurin, Joseph D Zuckerman, Mandeep S Virk
BACKGROUND: Newer generation humeral stem designs in total shoulder arthroplasty (TSA) are trending towards shorter lengths and uncemented fixation. The goal of this study is to report a 2-yr minimum clinical and radiographic outcomes of an uncemented short-stem press-fit humeral stem in anatomic total shoulder arthroplasty (ATSA) and reverse total shoulder arthroplasty (RTSA). METHODS: A retrospective multicenter database review was performed of all patients who received an uncemented short-length press-fit humeral stem (Equinoxe Preserve humeral stem, Exactech, Inc...
January 2024: JSES international
https://read.qxmd.com/read/38312294/analysis-of-factors-associated-with-patient-reported-outcome-pro-score-completion-rate-one-year-after-shoulder-surgeries
#31
JOURNAL ARTICLE
Paul V Romeo, Aidan G Papalia, Matthew G Alben, Luilly Vargas, Joseph D Zuckerman, Mandeep S Virk
BACKGROUND: Patient-reported outcome measurements (PROMs) are important metrics for monitoring improvements following shoulder surgery. Despite the easy accessibility of electronic PROM surveys, completion rates vary, and factors predictive of survey completion for patients enrolled in medical survey follow-up after shoulder surgery remain largely unknown. The purpose of this study is to investigate survey completion rates for common shoulder procedures and identify factors predictive of PROM completion at one-year postoperatively...
January 2024: JSES international
https://read.qxmd.com/read/38306638/sport-related-concussion-in-8-to-12-year-olds-an-understudied-population
#32
JOURNAL ARTICLE
Michael Zargari, Jacob Jo, Kristen Williams, Aaron M Yengo-Kahn, E Haley Vance, Christopher M Bonfield, Douglas P Terry, Scott L Zuckerman
OBJECTIVE: Most studies regarding sport-related concussion (SRC) focus on high school and collegiate athletes; however, little has been published on children younger than 12 years of age. In a cohort of children aged 8-12 years with SRC, the authors sought to describe demographics, initial presentation, and recovery in this understudied population. METHODS: A retrospective cohort study of children aged 8-12 years who sustained an SRC between November 2017 and April 2022 and were treated at a regional sports concussion center was conducted...
February 2, 2024: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/38302212/when-night-falls-fast-sleep-and-suicidal-behavior-among-adolescents-and-young-adults
#33
REVIEW
Sara N Fernandes, Emily Zuckerman, Regina Miranda, Argelinda Baroni
Sleep disturbances have been linked to suicidal ideation and behaviors in adolescents. Specifically, insomnia and nightmares are associated with current suicide risk and predict future ideation. Associations between hypersomnia, sleep apnea, and suicide remain inconclusive. Potential biological mechanisms underlying these relationships include executive functioning deficits and hyperarousal. Related psychological factors may include thwarted belongingness, perceived burdensomeness, and negative appraisals. Assessing suicide risk in patients with sleep disturbances, and vice versa, is needed...
March 2024: Psychiatric Clinics of North America
https://read.qxmd.com/read/38297120/single-neuronal-elements-of-speech-production-in-humans
#34
JOURNAL ARTICLE
Arjun R Khanna, William Muñoz, Young Joon Kim, Yoav Kfir, Angelique C Paulk, Mohsen Jamali, Jing Cai, Martina L Mustroph, Irene Caprara, Richard Hardstone, Mackenna Mejdell, Domokos Meszéna, Abigail Zuckerman, Jeffrey Schweitzer, Sydney Cash, Ziv M Williams
Humans are capable of generating extraordinarily diverse articulatory movement combinations to produce meaningful speech. This ability to orchestrate specific phonetic sequences, and their syllabification and inflection over subsecond timescales allows us to produce thousands of word sounds and is a core component of language1,2 . The fundamental cellular units and constructs by which we plan and produce words during speech, however, remain largely unknown. Here, using acute ultrahigh-density Neuropixels recordings capable of sampling across the cortical column in humans, we discover neurons in the language-dominant prefrontal cortex that encoded detailed information about the phonetic arrangement and composition of planned words during the production of natural speech...
January 31, 2024: Nature
https://read.qxmd.com/read/38293173/single-cell-morphodynamical-trajectories-enable-prediction-of-gene-expression-accompanying-cell-state-change
#35
Jeremy Copperman, Ian C Mclean, Sean M Gross, Young Hwan Chang, Daniel M Zuckerman, Laura M Heiser
Extracellular signals induce changes to molecular programs that modulate multiple cellular phenotypes, including proliferation, motility, and differentiation status. The connection between dynamically adapting phenotypic states and the molecular programs that define them is not well understood. Here we develop data-driven models of single-cell phenotypic responses to extracellular stimuli by linking gene transcription levels to "morphodynamics" - changes in cell morphology and motility observable in time-lapse image data...
January 19, 2024: bioRxiv
https://read.qxmd.com/read/38291995/comparison-of-multiple-surgical-treatments-for-massive-irreparable-rotator-cuff-tears-in-patients-younger-than-70-years-of-age-a-systematic-review-and-network-meta-analysis
#36
JOURNAL ARTICLE
Andrew S Bi, Utkarsh Anil, Christopher A Colasanti, Young W Kwon, Mandeep S Virk, Joseph D Zuckerman, Andrew S Rokito
BACKGROUND: Massive irreparable rotator cuff tears (MIRCTs) remain a challenging treatment paradigm, particularly for nonelderly patients without pseudoparalysis or arthritis. PURPOSE: To use a network meta-analysis to analyze comparative studies of surgical treatment options for MIRCTs in patients <70 years of age for several patient-reported outcomes, range of motion (ROM), and acromiohumeral distance (AHD). STUDY DESIGN: Network meta-analysis of comparative studies; Level of evidence, 3...
January 31, 2024: American Journal of Sports Medicine
https://read.qxmd.com/read/38255377/examining-the-association-between-psychopathic-traits-and-fearlessness-among-maximum-security-incarcerated-male-adolescents
#37
JOURNAL ARTICLE
J Michael Maurer, Nathaniel E Anderson, Corey H Allen, Kent A Kiehl
Studies have reported positive associations between youth psychopathy scores and measures of 'fearlessness'. However, prior studies modified fearlessness items to be age appropriate, shifting from assessing hypothetical, extreme forms of physical risk-taking (e.g., flying an airplane) to normative risk-taking (e.g., riding bicycles downhill). We hypothesize that associations between youth psychopathy scores and alternative forms of sensation seeking (i.e., Disinhibition) have been conflated under a false fearlessness label...
January 3, 2024: Children
https://read.qxmd.com/read/38244684/does-preoperative-bilsky-score-predict-outcome-following-surgical-resection-of-primary-tumors-of-the-spine
#38
JOURNAL ARTICLE
Jeffrey W Chen, Hani Chanbour, Mitchell Bowers, Gabriel A Bendfeldt, Lakshmi Suryateja Gangavarapu, Soren Jonzzon, Steven G Roth, Amir M Abtahi, Scott L Zuckerman, Byron F Stephens
OBJECTIVE: In patients undergoing surgery for primary bone tumors of the spine, we sought to compare Bilsky score 0-1 vs. 2-3 in: 1) preoperative presentation, 2) perioperative variables, and 3) long-term outcomes. METHODS: A single-center, retrospective cohort study was undertaken of patients undergoing surgery for extradural, primary bone tumors of the spine between 01/2010-01/2021. The primary exposure variable was Bilsky score, dichotomized as 0-1 vs. 2-3. Survival analysis was performed to assess local recurrence (LR) and overall survival (OS)...
January 18, 2024: World Neurosurgery
https://read.qxmd.com/read/38243860/breast-imaging-fellowship-virtual-interviews-the-program-director-s-perspective
#39
JOURNAL ARTICLE
Janine Katzen, Jonathan Nguyen, Samantha Zuckerman, Lilian Wang, Gary Whitman, Victoria Mango
OBJECTIVE: To evaluate breast imaging fellowship program directors' perspectives on the virtual interview process. METHODS: A 20-question survey constructed by members of the Fellowship Match Committee of the Society of Breast Imaging was distributed to all 99 breast imaging program directors registered with the Society. An initial e-mail with a link to the survey was distributed on September 9, 2022, and the survey was closed on October 1, 2022. Results were compiled and a descriptive statistical analysis was performed utilizing Microsoft Excel...
January 19, 2024: Journal of breast imaging
https://read.qxmd.com/read/38241756/adherence-and-discontinuation-of-prescription-cannabidiol-for-the-management-of-seizure-disorders-at-an-integrated-care-center
#40
JOURNAL ARTICLE
J Paige Barnes, Holly Dial, Wendi Owens, Josh DeClercq, Leena Choi, Nisha B Shah, Autumn D Zuckerman, Kayla Johnson
OBJECTIVE: Evaluate adherence, discontinuation rates, and reasons for non-adherence and discontinuation of prescription CBD during the 12-months post-initiation period at an integrated care center. METHODS: This was a prospective study of patients prescribed CBD by a neurology clinic provider with initial prescription fulfillment through the center's specialty pharmacy from January 2019 through April 2020. Baseline demographics and reasons for non-adherence and/or discontinuation were collected from the electronic health record and pharmacy claims history was used to calculate adherence using proportion of days covered (PDC)...
February 2024: Epilepsy Research
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