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https://www.readbyqxmd.com/read/28802816/safety-and-efficacy-of-an-8-week-regimen-of-grazoprevir-plus-ruzasvir-plus-uprifosbuvir-compared-with-grazoprevir-plus-elbasvir-plus-uprifosbuvir-in-participants-without-cirrhosis-infected-with-hepatitis-c-virus-genotypes-1-2-or-3-c-crest-1-and-c-crest-2-part
#1
Edward J Gane, Stephen Pianko, Stuart K Roberts, Alexander J Thompson, Stefan Zeuzem, Eli Zuckerman, Ziv Ben-Ari, Graham R Foster, Kosh Agarwal, Alex L Laursen, Jan Gerstoft, Wei Gao, Hsueh-Cheng Huang, Brian Fitzgerald, Doreen Fernsler, Jerry J Li, Anjana Grandhi, Hong Liu, Feng-Hsiu Su, Shuyan Wan, Zhen Zeng, Huei-Ling Chen, Frank J Dutko, Bach-Yen T Nguyen, Janice Wahl, Michael N Robertson, Eliav Barr, Wendy W Yeh, Rebeca M Plank, Joan R Butterton, Rafael Esteban
BACKGROUND: New hepatitis C virus (HCV) therapies with pan-genotypic efficacy are needed. The goals of part A of C-CREST-1 and C-CREST-2 were to compare the efficacies of two doses (300 mg or 450 mg once daily) of uprifosbuvir (MK-3682; NS5B inhibitor) in an 8-week regimen combined with grazoprevir (NS3/4A inhibitor; 100 mg once daily) and an NS5A inhibitor, either elbasvir (50 mg once daily) or ruzasvir (MK-8408; 60 mg once daily), and to evaluate the safety and tolerability of these combination regimens in individuals infected with genotypes 1, 2, or 3...
August 9, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28794581/comparison-of-general-versus-isolated-regional-anesthesia-in-total-shoulder-arthroplasty-a-retrospective-propensity-matched-cohort-analysis
#2
David Y Ding, Siddharth A Mahure, Brent Mollon, Steven D Shamah, Joseph D Zuckerman, Young W Kwon
BACKGROUND: Intraoperative anesthetic typically consists of either general anesthesia (GA) or isolated regional anesthesia (RA). METHODS: A retrospective propensity-matched cohort analysis on patients undergoing TSA was performed to determine differences between GA and RA in regard to patient population, complications, LOS and hospital readmission. RESULTS: 4158 patients underwent TSA with GA or isolated RA. Propensity-matching resulted in 912 patients in each cohort...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28783833/setting-the-record-straight-on-fda-approvals-in-oncology-reply
#3
Diana Zuckerman
No abstract text is available yet for this article.
August 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28780921/neo-oogenesis-in-mammals
#4
Tania Janeth Porras-Gómez, Norma Moreno-Mendoza
Recently, the existence of a mechanism for neo-oogenesis in the ovaries of adult mammals has generated much controversy within reproductive biology. This mechanism, which proposes that the ovary has cells capable of renewing the follicular reserve, has been described for various species of mammals. The first evidence was found in prosimians and humans. However, these findings were not considered relevant because the predominant dogma for reproductive biology at the time was that of Zuckerman. This dogma states that female mammals are born with finite numbers of oocytes that decline throughout postnatal life...
August 7, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28776136/comparison-of-echocardiographic-diagnostic-criteria-of-left-ventricular-noncompaction-in-a-pediatric-population
#5
Anna Joong, Denise A Hayes, Brett R Anderson, Warren A Zuckerman, Sheila J Carroll, Wyman W Lai
BACKGROUND: There is controversy regarding the best echocardiographic diagnostic criteria for left ventricular noncompaction (LVNC). We assessed the diagnostic utility and reproducibility of the previously proposed echocardiographic diagnostic criteria in a pediatric population using a segmental approach. METHODS: Echocardiograms were matched for patients with and without a clinical diagnosis of LVNC. Blinded reviews of echocardiograms measured (1) depths of intertrabecular recesses (X/Y), (2) noncompaction-to-compaction ratio (NC/C), and (3) number of trabeculations, using a segmental approach...
August 3, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28773112/corrosion-and-tribology-of-materials-used-in-a-novel-reverse-hip-replacement
#6
Linda Braddon, Zafer Termanini, Steven MacDonald, Jay Parvizi, Jay Lieberman, Victor Frankel, Joseph Zuckerman
Total hip arthroplasty has been utilized for the past 50 years as an effective treatment for degenerative, inflammatory and traumatic disorders of the hip. The design of these implants has generally followed the anatomy of the hip as a ball and socket joint with the femoral head representing the ball and the acetabulum representing the socket. We describe a novel hip arthroplasty design in which the "ball" is located on the acetabular side and the "socket" is located on the femoral side. The results of extensive biomechanical testing are described and document wear and corrosion characteristics that are at least equivalent to standard designs...
July 5, 2017: Materials
https://www.readbyqxmd.com/read/28736353/sport-related-structural-brain-injury-three-cases-of-subdural-hemorrhage-in-american-high-school-football
#7
Aaron M Yengo-Kahn, Ryan M Gardner, Andrew W Kuhn, Gary S Solomon, Christopher M Bonfield, Scott L Zuckerman
BACKGROUND: The risk of sport-related concussion (SRC) has emerged as a major public health concern. In rare instances, sport-related head injuries can be even more severe, such as subdural hemorrhage, epidural hemorrhage, or malignant cerebral edema. Unlike SRCs, sport-related structural brain injury (SRSBI) is rare, may require neurosurgical intervention, and can lead to permanent neurologic deficit or death. Data characterizing SRSBI is limited and many have recognized the need to better understand these catastrophic brain injuries...
July 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28729913/personality-traits-and-perception-of-m%C3%A3-ller-lyer-illusion-in-male-chinese-military-soldiers-and-university-students
#8
Yingchun Zhang, Jing Liu, Yongli Wang, Jingyi Huang, Lili Wei, Bingren Zhang, Wei Wang, Wei Chen
BACKGROUND: In military men, performance such as gun-shooting precision relies on factors such as the ability to resist visual illusion, and this misperception of visual stimulus might be linked with sensation seeking related personality. METHODS: We have invited 103 male military men and 104 age-matched university male students to undergo the experiment of the Brentano version of the Müller-Lyer illusion and the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ) tests...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28724103/nematode-community-response-to-green-infrastructure-design-in-a-semiarid-city
#9
Mitchell A Pavao-Zuckerman, Christine Sookhdeo
Urbanization affects ecosystem function and environmental quality through shifts in ecosystem fluxes that are brought on by features of the built environment. Green infrastructure (GI) has been suggested as a best management practice (BMP) to address urban hydrologic and ecological impacts of the built environment, but GI practice has only been studied from a limited set of climatic conditions and disciplinary approaches. Here, we evaluate GI features in a semiarid city from the perspective of soil ecology through the application of soil nematode community analysis...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28717900/elements-of-program-design-in-medicare-s-value-based-and-alternative-payment-models-a-narrative-review
#10
Karen E Joynt Maddox, Aditi P Sen, Lok Wong Samson, Rachael B Zuckerman, Nancy DeLew, Arnold M Epstein
Increasing emphasis on value in health care has spurred the development of value-based and alternative payment models. Inherent in these models are choices around program scope (broad vs. narrow); selecting absolute or relative performance targets; rewarding improvement, achievement, or both; and offering penalties, rewards, or both. We examined and classified current Medicare payment models-the Hospital Readmissions Reduction Program (HRRP), Hospital Value-Based Purchasing Program (HVBP), Hospital-Acquired Conditions Reduction Program (HACRP), Medicare Advantage Quality Star Rating program, Physician Value-Based Payment Modifier (VM) and its successor, the Merit-Based Incentive Payment System (MIPS), and the Medicare Shared Savings Program (MSSP) on these elements of program design and reviewed the literature to place findings in context...
July 17, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28716694/-isolated-long-thoracic-nerve-palsy-more-than-meets-the-eye
#11
Andrés A Maldonado, Scott L Zuckerman, B Matthew Howe, Michelle L Mauermann, Robert J Spinner
INTRODUCTION: Two main hypotheses have been proposed for the pathophysiology of long thoracic nerve (LTN) palsy: nerve compression and nerve inflammation. We hypothesized that critical reinterpretation of electrodiagnostic (EDX) studies and MRIs of patients with a diagnosis of non-traumatic isolated LTN palsy could provide insight into the pathophysiology and, potentially, the treatment. MATERIAL AND METHODS: A retrospective review was performed of all patients with a diagnosis of non-traumatic isolated LTN palsy and an EDX and brachial plexus or shoulder MRI studies performed at our institution...
June 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28715290/trainees-knowledge-attitudes-and-practices-towards-caring-for-the-substance-exposed-mother-infant-dyad
#12
Davida M Schiff, Barry Zuckerman, Elisha M Wachman, Megan Bair-Merritt
BACKGROUND: As rates of substance use disorder during pregnancy rise, pediatric trainees are increasingly caring for infants with neonatal abstinence syndrome (NAS). This study evaluated the knowledge, attitudes, and practices of trainees caring for substance-exposed newborns and their families, comparing differences by level and type of training, and personal experience with addiction or trauma. METHODS: A cross-sectional survey of medical students, pediatric, medicine/pediatrics and family medicine residents in 2015-2106...
July 17, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28688967/personality-factors-associated-with-resident-performance-results-from-12-accreditation-council-for-graduate-medical-education-accredited-orthopaedic-surgery-programs
#13
Donna Phillips, Kenneth A Egol, Martine C Maculatis, Kathryn S Roloff, Alan M Friedman, Brett Levine, Steven Garfin, Alexandra Schwartz, Robert Sterling, Thomas Kuivila, Steve J Paragioudakis, Joseph D Zuckerman
OBJECTIVES: To understand the personality factors associated with orthopedic surgery resident performance. DESIGN: A prospective, cross-sectional survey of orthopedic surgery faculty that assessed their perceptions of the personality traits most highly associated with resident performance. Residents also completed a survey to determine their specific personality characteristics. A subset of faculty members rated the performance of those residents within their respective program on 5 dimensions...
July 5, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28678036/automated-noninvasive-blood-pressure-monitors-a-food-and-drug-administration-review-perspective
#14
COMMENT
Bradley Quinn, Shawn Forrest, Matthew Hillebrenner, Bram Zuckerman
No abstract text is available yet for this article.
August 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28676624/recurrent-pleural-effusion-secondary-to-a-pancreatic-pleural-fistula-treated-endoscopically
#15
Marco Antonio Bustamante Bernal, Jose Lisandro Gonzalez Martinez, Arleen Ortiz, Marc J Zuckerman
BACKGROUND Pancreatic-pleural fistula (PPF) is an uncommon complication of pancreatitis. Pleural effusions secondary to PPF are caused by fistulization of pancreatic secretions to the thorax derived from the rupture or leakage of a pseudocyst. CASE REPORT We describe the case of a 44-year-old male with recurrent right-sided pleural effusions and alcoholic pancreatitis who presented with epigastric pain and shortness of breath. Pleural fluid analysis revealed an amylase of 7002 U/lt. MRCP showed segmental narrowing and stricture of the proximal main pancreatic duct and an area of walled-off necrosis...
July 5, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28673407/estimating-concussion-incidence-using-sports-injury-surveillance-systems-complexities-and-potential-pitfalls
#16
REVIEW
Zachary Y Kerr, Scott L Zuckerman, Johna K Register-Mihalik, Erin B Wasserman, Tamara C Valovich McLeod, Thomas P Dompier, R Dawn Comstock, Stephen W Marshall
Numerous sports injury surveillance systems exist with the capability of tracking concussion incidence data. It is important for the consumers of sport-related concussion data, be they researchers or the public, to have a comprehensive understanding of the strengths and limitations of sports injury surveillance systems. This article discusses issues of system design and analysis that affect the interpretation and understanding of sport-related concussion incidence data from sports injury surveillance systems...
August 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28669453/infant-regulatory-problems-and-obesity-in-early-childhood
#17
Elizabeth Peacock-Chambers, Jenny S Radesky, Samantha E Parker, Barry Zuckerman, Julie C Lumeng, Michael Silverstein
OBJECTIVE: Difficult infant temperament is associated with higher weight status in infancy. However, the association of infant temperament, including regulatory capacities, has not been well studied as a possible predictor of future weight status in early childhood. We examined prospective associations of infant regulatory difficulties with obesity in early childhood in a large, diverse cohort. METHODS: We used data from 5750 children in the Early Childhood Longitudinal Study-Birth Cohort, excluding preterm infants and infants small or large for gestational age...
July 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28665679/making-sense-of-advanced-payment-models
#18
Barbara McAneny, Stephen S Grubbs, Walter Birch, Dan Sayam Zuckerman
No abstract text is available yet for this article.
April 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28664768/a-biomechanical-comparison-of-the-two-and-four-hole-side-plate-dynamic-hip-screw-in-an-osteoporotic-composite-femur-model
#19
Dominik Rog, Phillip Grigsby, Zachary Hill, William Pinette, Serkan Inceoglu, Lee Zuckerman
OBJECTIVES: The objectives of this study were (1) to compare the axial and torsional stiffness of a dynamic hip screw with a two- and four-hole side-plate in a synthetic model of a healed and stable intertrochanteric femur fracture and (2) to evaluate the load to failure, as well as propensity to peri-implant fracture. METHODS: Fourth-generation synthetic composite femur models, simulating osteoporotic bone, were implanted with 135° dynamic hip screws (DHS) with either a two- or four-hole side-plate with or without a stable intertrochanteric fracture...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28658041/utility-of-intraoperative-monitoring-in-the-resection-of-spinal-cord-tumors-an-analysis-by-tumor-location-and-anatomical-region
#20
Nikita Lakomkin, Akshitkumar M Mistry, Scott L Zuckerman, Travis Ladner, Parth Kothari, Nathan John Lee, Blaine Stannard, Raul A Vasquez, Joseph S Cheng
STUDY DESIGN: Retrospective review of institutional data OBJECTIVE.: The aim of this study was to assess the utility of somatosensory-evoked potentials (SSEP) and transcranial electric motor-evoked potentials (MEP) in the resection of spine tumors and evaluate the ability of both single and multi-modal monitoring to predict post-operative neurological deficits. SUMMARY OF BACKGROUND DATA: While the utility of intraoperative monitoring (IOM) is well established in scoliosis and degenerative surgery, studies in spine tumor patients have been limited...
June 27, 2017: Spine
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