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https://www.readbyqxmd.com/read/28191313/metastatic-biomarkers-in-synovial-sarcoma
#1
REVIEW
Rosalia de Necochea-Campion, Lee M Zuckerman, Hamid R Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen, Saied Mirshahidi
Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical management is the mainstay of treatment with chemotherapy and radiation typically used as adjuvant treatment. Although chemotherapy has a positive impact on survival, the prognosis is poor if metastatic disease occurs. The biology of sarcoma invasion and metastasis remain poorly understood. Chromosomal translocation with fusion of the SYT and SSX genes has been described and is currently used as a diagnostic marker, although the full impact of the fusion is unknown...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28175509/mechanisms-of-injury-as-a-diagnostic-predictor-of-sport-related-concussion-severity-in-football-basketball-and-soccer-results-from-a-regional-concussion-registry
#2
Scott L Zuckerman, Douglas J Totten, Kolin E Rubel, Andrew W Kuhn, Aaron M Yengo-Kahn, Gary S Solomon
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175489/174%C3%A2-mechanisms-of-injury-as-a-diagnostic-predictor-of-sport-related-concussion-severity-in-football-basketball-and-soccer-results-from-a-regional-concussion-registry
#3
Scott L Zuckerman, Doug Totten, Kolin Rubel, Andrew W Kuhn, Aaron M Yengo-Kahn, Gary Solomon, Allen K Sills
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175468/184%C3%A2-interrelationships-among-neuroimaging-biomarkers-neuropsychological-test-data-and-symptom-reporting-in-a-cohort-of-retired-national-football-league-players
#4
Andrew W Kuhn, Scott L Zuckerman, Gary Solomon, Ira Casson
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28165855/genome-wide-dna-methylation-associations-with-spontaneous-preterm-birth-in-us-blacks-findings-in-maternal-and-cord-blood-samples
#5
Xiumei Hong, Ben Sherwood, Christine Ladd-Acosta, Shouneng Peng, Hongkai Ji, Ke Hao, Irina Burd, Tami R Bartell, Guoying Wang, Hui-Ju Tsai, Xin Liu, Yuelong Ji, Anastacia Wahl, Deanna Caruso, Aviva Lee-Parritz, Barry Zuckerman, Xiaobin Wang
Preterm birth (PTB) affects one in six U.S. Black babies. Epigenetics is believed to play a role in PTB; however, only a limited number of epigenetic studies of PTB have been reported, most of which have focused on cord blood DNA methylation (DNAm) and/or were conducted in white populations. Here we conducted, by far, the largest epigenome-wide DNAm analysis in 300 Black women who delivered early spontaneous preterm (sPTB, n = 150) or full-term babies (n = 150) and replicated the findings in an independent set of Black mother-newborn pairs from the Boston Birth Cohort...
February 6, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28165690/bullying-harms-victims-and-perpetrators-of-all-ages
#6
Diana Zuckerman
Bullying used to be considered an unfortunate, inevitable rite of childhood, but researchers now tell us that bullying often occurs in conjunction with more serious aggressive and antisocial behavior. They conclude that bullying, therefore, should not be considered a normal and accepted part of growing up.
July 2016: Health Progress
https://www.readbyqxmd.com/read/28161798/behavioral-and-inflammatory-response-in-animals-exposed-to-a-low-pressure-blast-wave-and-supplemented-with-%C3%AE-alanine
#7
Jay R Hoffman, Amitai Zuckerman, Omri Ram, Oren Sadot, Jeffrey R Stout, Ishay Ostfeld, Hagit Cohen
This study investigated the benefit of β-alanine (BA) supplementation on behavioral and cognitive responses relating to mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) in rats exposed to a low-pressure blast wave. Animals were fed a normal diet with or without (PL) BA supplementation (100 mg kg(-1)) for 30-day, prior to being exposed to a low-pressure blast wave. A third group of animals served as a control (CTL). These animals were fed a normal diet, but were not exposed to the blast...
February 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28159734/monocyte-subset-analysis-accurately-distinguishes-cmml-from-mds-and-is-associated-with-a-favorable-mds-prognosis
#8
Chetasi Talati, Ling Zhang, Ghada Shaheen, Andrew Kuykendall, Markus Ball, Qing Zhang, Jeffrey E Lancet, Kenneth S Zuckerman, Alan F List, Rami Komrokji, Lynn Moscinski, Eric Padron
No abstract text is available yet for this article.
February 3, 2017: Blood
https://www.readbyqxmd.com/read/28153199/fda-in-the-21st-century-focus-on-tobacco-policies-and-heart-failure-prevention
#9
EDITORIAL
Mona Fiuzat, Tamar S Nordenberg, Mitchell Zeller, Matthew G Hillebrenner, Norman Stockbridge, Bram Zuckerman, Robert M Califf
No abstract text is available yet for this article.
February 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28151865/differential-effects-of-stress-and-african-ancestry-on-preterm-birth-and-related-traits-among-us-born-and-immigrant-black-mothers
#10
Hui-Ju Tsai, Pamela J Surkan, Stella M Yu, Deanna Caruso, Xiumei Hong, Tami R Bartell, Anastacia D Wahl, Claire Sampankanpanich, Anne Reily, Barry S Zuckerman, Xiaobin Wang
Preterm birth (PTB, <37 weeks of gestation) is influenced by a wide range of environmental, genetic and psychosocial factors, and their interactions. However, the individual and joint effects of genetic factors and psychosocial stress on PTB have remained largely unexplored among U.S. born versus immigrant mothers.We studied 1121 African American women from the Boston Birth Cohort enrolled from 1998 to 2008. Regression-based analyses were performed to examine the individual and joint effects of genetic ancestry and stress (including lifetime stress [LS] and stress during pregnancy [PS]) on PTB and related traits among U...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28149729/arthroscopic-rotator-cuff-repair-double-row-transosseous-equivalent-suture-bridge-technique
#11
Mina Abdelshahed, Siddharth A Mahure, Daniel J Kaplan, Brent Mollon, Joseph D Zuckerman, Young W Kwon, Andrew S Rokito
Following a failed course of conservative management, arthroscopic rotator cuff repair (ARCR) has become the gold standard treatment for patients presenting with symptomatic rotator cuff (RC) tears. Traditionally, the single-row repair technique was used. Although most patients enjoy good to excellent clinical outcomes, structural healing to bone remains problematic. As a result, orthopaedic surgeons have sought to improve outcomes with various technological and technical advancements. One such possible advancement is the double-row technique...
December 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28126071/psychometric-properties-of-the-brief-sensation-seeking-scale-in-peruvian-teenagers
#12
Silvana Romero Saletti, David Olivo Chang, Cecilia Chau Pérez-Aranibar, Fiorella Otiniano Campos
BACKGROUND: The Brief Sensation Seeking Scale – BSSS measures sensation seeking in teenagers based on Zuckerman’s theory, covering the need for a brief instrument that might be useful for research contexts and capable of correcting some defects in the SSS-V. The aim of this study was to adapt the BSSS for research purposes with students schoolchildren in Lima and determine its psychometric properties. METHOD: 1,033 high school students from four public schools in Lima completed the final version of the BSSS...
February 2017: Psicothema
https://www.readbyqxmd.com/read/28117899/benefits-of-a-psychodynamic-group-therapy-pgt-model-for-treating-veterans-with-ptsd
#13
Ofir Levi, Yael Shoval-Zuckerman, Eyal Fruchter, Arie Bibi, Yair Bar-Haim, Ilan Wald
OBJECTIVE: To examine the effectiveness of a treatment model of psychodynamic group therapy (PGT) for combat Veterans with posttraumatic stress disorder (PTSD). METHOD: A total of 158 male Veterans with PTSD (mean age = 30.09 years) were assigned to 15 treatment groups of 7-13 patients each. PGT was a 1-year therapy, 1.5 hour, once-a-week sessions administered in the following stages: group building activities, differentiation of group members, intimacy building, and termination...
January 24, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28111179/impact-of-scapular-notching-on-clinical-outcomes-after-reverse-total-shoulder-arthroplasty-an-analysis-of-476-shoulders
#14
Brent Mollon, Siddharth A Mahure, Christopher P Roche, Joseph D Zuckerman
BACKGROUND: Scapular notching is a complication unique to reverse total shoulder arthroplasty (rTSA), although its clinical implications are unclear and remains controversial. METHODS: We retrospectively reviewed rTSA patients of a single implant design in 476 shoulders with a minimum 2-year clinical and radiographic follow-up. Clinical measures included active range of motion and American Shoulder and Elbow Surgeons scores, in addition to one or more of the Constant score, Shoulder Pain and Disability Index, Simple Shoulder Test (SST), and University of California, Los Angeles Shoulder Rating Scale...
January 19, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28077851/the-legacy-of-s%C3%A3-ndor-ferenczi-from-ghost-to-ancestor-edited-by-adrienne-harris-and-steven-kuchuck-routledge-new-york-2015-300pp
#15
Janet Rivkin Zuckerman
No abstract text is available yet for this article.
December 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28067632/hcv-genotype-1-subtypes-and-resistance-associated-substitutions-in-drug-naive-and-in-direct-acting-antiviral-treatment-failure-patients
#16
Yael Gozlan, Ziv Ben-Ari, Roy Moscona, Rachel Shirazi, Avia Rakovsky, Arij Kabat, Ella Veizman, Tania Berdichevski, Peretz Weiss, Oranit Cohen-Ezra, Yoav Lurie, Inna Gafanovich, Marius Braun, Michal Cohen-Naftaly, Amir Shlomai, Oren Shibolet, Ehud Zigmond, Eli Zuckerman, Michal Carmiel-Haggai, Assy Nimer, Rawi Hazzan, Yaakov Maor, Yona Kitay-Cohen, Yonat Shemer, Zipi Kra-Oz, Lisita Schreiber, Ofer Peleg, Ella Mendelson, Orna Mor
BACKGROUND: Direct-acting antiviral (DAA) treatment regimens and response rates of patients with hepatitis C virus (HCV) genotype 1 (GT1) are currently considered subtype-dependent. Identification of clinically relevant resistance-associated substitutions (RASs) in the NS3 and NS5A proteins at baseline and in DAA failures, may also impact clinical decisions. METHODS: In a multicenter cohort study (n=308), NS3 or NS5B sequencing (n=248) was used to discriminate between GT1 subtypes...
January 9, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28060238/single-institution-early-experience-with-the-bundled-payments-for-care-improvement-initiative
#17
Richard Iorio, Joseph Bosco, James Slover, Yousuf Sayeed, Joseph D Zuckerman
The Centers for Medicare & Medicaid Services (CMS) implemented the Bundled Payments for Care Improvement (BPCI) initiative in 2011. Through BPCI, organizations enlisted into payment agreements that include both performance and financial accountability for episodes of care. To succeed, BPCI requires quality maintenance and care delivery at lower costs. This necessitates physicians and hospitals to merge interests. Orthopaedic surgeons must assume leadership roles in cost containment, surgical safety, and quality assurance to deliver cost-effective care...
January 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28044373/editorial
#18
EDITORIAL
Robert J Spinner, Scott L Zuckerman
No abstract text is available yet for this article.
January 3, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28042619/beating-the-odds-successful-establishment-of-a-phase-ii-iii-clinical-research-trial-in-resource-poor-liberia-during-the-largest-ever-ebola-outbreak
#19
J Doe-Anderson, B Baseler, P Driscoll, M Johnson, J Lysander, L McNay, W S Njoh, M Smolskis, L Wehrlen, J Zuckerman
It has been argued that a country such as Liberia, not fully recovered from the devastation of decades of civil unrest, lacked the appropriate ethical and regulatory framework, basic human and health care services, and infrastructure to carry out clinical trials according to international standards of quality during a public health emergency. However, as Liberia, Sierra Leone, and Guinea were being ravaged by the largest and most devastating Ebola Virus Disease (EVD) outbreak ever recorded, the topic of conducting clinical trials of experimental vaccine and treatment candidates in these resource-poor countries generated the keen interest and concern of scientists, researchers, physicians, bioethicists, philanthropists, and even politicians...
December 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28039512/efficacy-and-safety-of-autologous-hematopoietic-cell-transplantation-in-elderly-patients-with-multiple-myeloma-a-retrospective-national-multi-site-cohort-study
#20
MULTICENTER STUDY
Yael C Cohen, Tsila Zuckerman, Moshe Yeshurun, Galit Perez, Hila Magen, Israel Henig, Itai Levi, Liat Shargian, Svetlana Trestman, Uri Rouvio, Elizabeth Naparstek, Eti Ganon-Elazar, Irit Avivi, Ron Ram
We aimed to test the efficacy and toxicity of autologous hematopoietic cell transplant (HCT) in Multiple Myeloma (MM) patients aged ≥65 years compared to patients aged 60-64. Two hundred twenty consecutive patients (age ≥65, n = 87) with MM aged 60 and above, who underwent HCT as part of an upfront MM treatment, at four Israeli centers between 2000 and 2014 were included. A melphalan dose of 200 mg/m(2) was more frequent in the 60-64 age group vs. the ≥65 age group (77 vs. 57%, p = 0.002). There were no differences between groups in median day of neutrophil engraftment, incidence of infections, grades 3-4 mucositis, cardiovascular events, or non-relapse mortality at 100 days post HCT (4...
February 2017: Annals of Hematology
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