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Ariane Nunes-Alves, Daniel M Zuckerman, Guilherme Menegon Arantes
The T4 lysozyme L99A mutant is often used as a model system to study small-molecule binding to proteins, but pathways for ligand entry and exit from the buried binding site and the associated protein conformational changes have not been fully resolved. Here, molecular dynamics simulations were employed to model benzene exit from its binding cavity using the weighted ensemble (WE) approach to enhance sampling of low-probability unbinding trajectories. Independent WE simulations revealed four pathways for benzene exit, which correspond to transient tunnels spontaneously formed in previous simulations of apo T4 lysozyme...
March 13, 2018: Biophysical Journal
J David Guerrero-Apolo, J Blas Navarro-Pastor, Antonio Bulbena-Vilarrasa, Julián Gabarre-Mir
OBJECTIVE: Impulsiveness has been the subject of much research, but little is known about the possible relationship between craniofacial anatomy and impulsiveness. The present study was designed to investigate the relationship between one aspect of craniofacial structure (the angle of inclination of the forehead) and impulsiveness. METHOD: Photographs in profile were obtained from 131 volunteers who had been fined for driving at high speed and were undergoing a court-mandated driving license point-recovery course...
March 12, 2018: Revista Brasileira de Psiquiatria
Rebecca M Zuckerman, Rebecca L Silton, Frank F Tu, Joshua S Eng, Kevin M Hellman
Somatic symptoms are a robust, transdiagnostic risk factor for pain conditions. However, the extent to which somatic symptoms contribute to the manifestation of the women's pain syndromes, such as dysmenorrhea and noncyclic pelvic pain (NCPP), is unclear due to high rates of co-occurrence. Therefore, the present study investigated the primary hypothesis that somatic symptoms would be elevated in NCPP and distinctly influence the relationship between dysmenorrhea and co-occurring NCPP. A secondary analysis was performed on cross-sectional questionnaire data from 1012 nonpregnant reproductive-aged women...
March 10, 2018: Archives of Women's Mental Health
Silvia Martina Ferrari, Guido Bocci, Teresa Di Desidero, Giusy Elia, Ilaria Ruffilli, Francesca Ragusa, Paola Orlandi, Sabrina Rosaria Paparo, Armando Patrizio, Simona Piaggi, Concettina La Motta, Salvatore Ulisse, Enke Baldini, Gabriele Materazzi, Paolo Miccoli, Alessandro Antonelli, Poupak Fallahi
Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor (TKI) of VEGFR1-VEGFR3, FGFR1-FGFR4, PDGFRα, RET and v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) signaling networks involved in tumor angiogenesis. We have evaluated the antitumor activity of lenvatinib in primary anaplastic thyroid cancer (ATC) cells, in the human cell line 8305C (undifferentiated thyroid cancer) and in an ATC-cell line (AF). The AF cell line was obtained from the primary ATC cultures and was the one that grew over 50 passages...
March 8, 2018: Oncology Reports
Lei Zhang, Zhimin Geng, Xiankui Meng, Fandi Meng, Lin Wang
The present study aimed to investigate key long non-coding RNAs (lncRNAs) and genes, and to obtain insights into their roles in the progression of gallbladder cancer (GBC). The gene expression profile and non‑coding RNA profile of GSE62335, which included five separate GBC tissue samples and five matched adjacent gallbladder normal tissue samples, was downloaded from the Gene Expression Omnibus database. The differentially expressed lncRNAs and mRNAs in the GBC tissues were identified, following which RNA binding protein analysis was performed using starBase v2...
March 1, 2018: Molecular Medicine Reports
Jessica Bernica, Sherif Alhanafi, Neeharika Kalkota, Yi Jia, Christopher Dodoo, Alok Dwivedi, Robert J Sealock, Kalpesh Patel, Isaac Raijman, Marc J Zuckerman, Mohamed Othman
BACKGROUND: Although cholangioscopy is a widespread technique used during Endoscopic Retrograde Cholangiopancreatiography (ERCP), its safety and feasibility in the elderly are not well established. This study aims to evaluate the safety and feasibility of ERCP in elderly patients. METHODS: A retrospective study of all ERCPs with single operator cholangioscopy (SOC) was conducted at three tertiary referral hospitals between March 2012 and October 2015 (specific dates varying by center)...
March 2, 2018: Clinical Gastroenterology and Hepatology
Jamie K Harrington, Warren A Zuckerman, Anjali Chelliah
If coronary artery sequelae are the only suggestive signs of previous Kawasaki disease, the diagnosis may easily be missed. We describe a rare case of a child with severe occlusive coronary disease likely owing to missed Kawasaki disease. This diagnosis was not initially considered given the age and absence of suggestive history. Careful echocardiographic assessment and low-radiation coronary CT angiogram resulted in successful diagnosis and treatment.
March 5, 2018: Cardiology in the Young
N Ashwanikumar, Justin S Plaut, Barmak Mostofian, Siddharth Patel, Peter Kwak, Conroy Sun, Kerry McPhail, Daniel M Zuckerman, Sadik C Esener, Gaurav Sahay
Despite recent advances in the supramolecular assembly of cell-penetrating peptide (CPP) nanostructures, the tuning of size, shape, morphology and packaging of drugs in these materials still remain unexplored. Herein, through sequential ligation of peptide building blocks, we create cell-penetrating self-assembling peptide nanomaterials (CSPNs) with the capability to translocate inside cells. We devised a triblock array of Tat48-59 [HIV-1 derived transactivator of transcription48-59 ] based CPPs, conjugated to up to four Phenylalanine (Phe) residues through an amphiphilic linker, (RADA)2 ...
March 1, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Itay Tokatly Latzer, Marianna Rachmiel, Nehama Zuckerman Levin, Kineret Mazor-Aronovitch, Zohar Landau, Rachel Frumkin Ben-David, Chana GrafBar-El, Noah Gruber, Noa Levek, Batia Weiss, Daniel Stein, Liat Lerner-Geva, Orit Pinhas-Hamiel
BACKGROUND: Disordered eating behaviors (DEBs) may lead to full blown eating disorders. Both type 1 diabetes mellitus (T1DM) and celiac disease (CD) have been linked to DEBs. OBJECTIVE: To compare the presence of DEBs between adolescents and young adults with a dual diagnosis of T1DM and CD, and individuals with only one of the diagnoses. METHODS: Individuals with a dual diagnosis of T1DM and CD ("T1DM + CD group" n = 39), with a diagnosis of T1DM only ("T1DM group" n = 97) and with a diagnosis of CD only ("CD group" n = 267) filled the Eating Attitude Test-26 (EAT-26) questionnaire...
March 1, 2018: Pediatric Diabetes
Scott L Zuckerman, Mark H Bilsky, Ilya Laufer
BACKGROUND: Chordomas are rare, primary bone tumors that arise from the axial skeleton. Our objective was to analyze trends in radiation and surgery over time and determine location-based survival predictors for chordomas of the skull base, mobile spine, and sacrum. METHODS: A retrospective cohort study of the Surveillance Epidemiology and End Results (SEER) database from 1973-2013 was conducted. All patients had histologically confirmed chordomas. The principal outcome measure was overall survival (OS)...
February 24, 2018: World Neurosurgery
Benjamin L Brett, Andrew W Kuhn, Aaron M Yengo-Kahn, Gary S Solomon, Scott L Zuckerman
Objective: The empirical identification of risk factors associated with sport-related concussion (SRC) may improve the management of student-athletes. The current study attempted to identify and quantify bio-cognitive risk factors associated with sustaining a SRC. Methods: Cross-sectional ambispective study; level of evidence, 3. Neurocognitive testing of 12,320 middle school, high school and collegiate athletes was completed at preseason baseline and post-SRC. Univariate and multivariable logistic regressions were used to determine which pre-injury variables accurately predicted the occurrence of SRC...
February 17, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Peter C Taylor, Joel M Kremer, Paul Emery, Steven H Zuckerman, Giacomo Ruotolo, Jinglin Zhong, Lei Chen, Sarah Witt, Chadi Saifan, Monika Kurzawa, James D Otvos, Margery A Connelly, William L Macias, Douglas E Schlichting, Terence P Rooney, Stephanie de Bono, Iain B McInnes
OBJECTIVES: Lipid profiles are altered by active disease in patients with rheumatoid arthritis (RA) and may be further modified by treatment with Janus kinase inhibitors and other disease-modifying antirheumatic drugs. METHODS: Lipid data were analysed from phase II and III studies of 4 mg (n=997) and 2 mg (n=479) oral baricitinib administered once daily in patients with moderate-to-severe active RA. Lipoprotein particle size and number and GlycA were evaluated with nuclear magnetic resonance in one phase III study...
February 20, 2018: Annals of the Rheumatic Diseases
Alexandros Kapsomenakis, Panagiotis G Simos, Georgios Konstantakopoulos, Dimitrios S Kasselimis
Pathological gambling is characterized by a persisting maladaptive and recurrent behavior with severe social and psychological consequences. There is evidence of strong comorbidity with psychiatric manifestations as well as cognitive mainly involving executive functions. This study aimed to investigate impairment in executive functions and working memory, and personality traits in a sample of Greek gamblers. Twenty-four men involved in various gambling activities were recruited from ecological settings as probable pathological gamblers...
February 17, 2018: Journal of Gambling Studies
Warren A Zuckerman, Adriana Zeevi, Kristen L Mason, Brian Feingold, Carol Bentlejewski, Linda J Addonizio, Elizabeth D Blume, Charles E Canter, Anne I Dipchand, Daphne T Hsu, Robert E Shaddy, William T Mahle, Anthony J Demetris, David M Briscoe, Thalachallour Mohanakumar, Joseph M Ahearn, David N Iklé, Brian D Armstrong, Yvonne Morrison, Helena Diop, Jonah Odim, Steven A Webber
Anti-HLA donor-specific antibodies are associated with worse outcomes following organ transplantation. Among sensitized pediatric heart candidates, requirement for negative donor-specific cytotoxicity crossmatch increases wait times and mortality. However, transplantation with positive crossmatch may increase post-transplant morbidity and mortality. We address this clinical challenge in a prospective, multi-center, observational cohort study of children listed for heart transplantation (CTOTC-04). Outcomes were compared among sensitized recipients who underwent transplant with positive crossmatch, non-sensitized recipients, and sensitized recipients without positive crossmatch...
February 15, 2018: American Journal of Transplantation
A I Dipchand, S Webber, K Mason, B Feingold, C Bentlejewski, W T Mahle, R Shaddy, C Canter, E D Blume, J Lamour, W Zuckerman, H Diop, Y Morrison, B Armstrong, D Ikle, J Odim, A Zeevi
Data on the clinical importance of newly detected donor specific antibodies (ndDSA) following pediatric heart transplantation is lacking despite mounting evidence of the detrimental effect of de novo DSA in solid organ transplantation. We prospectively tested 237 pediatric heart transplant recipients for ndDSA in the first year post-transplant in order to determine their incidence, pattern and clinical impact. One third of patients developed ndDSA; when present, these were mostly detected within the first 6 weeks after transplant suggesting that memory responses may predominate over true de novo DSA production in this population...
February 14, 2018: American Journal of Transplantation
Cassidy A Pomeroy-Carter, Sharon R Williams, Xueying Han, William N Elwood, Brian L Zuckerman
The National Institutes of Health (NIH) K18 award mechanism provides funded opportunities for established investigators to gain knowledge in fields outside of their primary disciplines, but outcomes associated with these awards have not been evaluated to date. NIH's Basic Behavioral and Social Sciences Opportunity Network (OppNet) is one of the few initiatives that has used this award mechanism. We explored how the unique features of K18 awards affect the ability of recipients to obtain follow-on NIH research funding...
2018: PloS One
Nishit Mummareddy, Akshitkumar M Mistry, Reid C Thompson, Scott L Zuckerman
No abstract text is available yet for this article.
February 2018: World Neurosurgery
Yi Li, Yangfan Li, Martin Kappas, Mitchell Pavao-Zuckerman
Pursuit of sustainability requires a systematic approach to understand a system's specific dynamics to adapt and enhance from disturbances in social-environmental systems. We developed a systematic resilience assessment of social-environmental systems by connecting catastrophe theory and probability distribution equilibrium. Catastrophe models were used to calculate resilience shifts between slow and fast variables; afterwards, two resilience transition modes ("Less resilient" or "More resilient") were addressed by using probability distribution equilibrium analysis...
February 8, 2018: Environment International
Janet Rivkin Zuckerman
No abstract text is available yet for this article.
February 8, 2018: American Journal of Psychoanalysis
Alex M Muruppel, Joyce Thomas, Sudeep Saratchandran, Dinesh Nair, Sheeba Gladstone, Milen M Rajeev
AIM: This in vitro study evaluated the resistance form of die preparations for all ceramic restorations and, thereby, explored the concept of effective taper and its correlation between the ideal in theory and actual in the clinical situation by analyzing the digital images of the die preparations. MATERIALS AND METHODS: Scanned digital images of 114 die preparations for all ceramic restorations (n = 114) were collected from a dental laboratory. All the images were also analyzed digitally using Adobe Photoshop® software to analyze the degree of taper (angle of convergence) of each preparation and then applied the Zuckerman's circle, and the Lewis perpendicular methods were used to measure the resistance form...
February 1, 2018: Journal of Contemporary Dental Practice
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