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https://www.readbyqxmd.com/read/29767224/innovative-technique-for-endoscopic-placement-of-sengstaken-blakemore-tube
#1
Arleen M Ortiz, Cesar J Garcia, Mohamed O Othman, Marc J Zuckerman
OBJECTIVES: The Sengstaken-Blakemore (SB) tube is used in cases of uncontrolled variceal bleeding. Because of the complexity of the procedure and the lack of visualization, various techniques have been described to avoid blind placement. We report an innovative and simple technique for placement of the SB tube under direct endoscopic visualization. METHODS: A grasp-and-place technique for endoscopic placement of SB tubes is described and a retrospective cohort study chart review of endoscopies done for variceal bleeding in our medical center is reported...
May 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29765756/effect-of-counter-ion-on-packing-and-crystal-density-of-5-5-3-3-bi-1-2-4-oxa-diazole-5-5-di-yl-bis-1-h-tetra-zol-1-olate-with-five-different-cations
#2
Ian D Giles, Alan J DeHope, Nathaniel B Zuckerman, Damon A Parrish, Philip F Pagoria
In energetic materials, the crystal density is an important parameter that affects the performance of the material. When making ionic energetic materials, the choice of counter-ion can have detrimental or beneficial effects on the packing, and therefore the density, of the resulting energetic crystal. Presented herein are a series of five ionic energetic crystals, all containing the dianion 5,5'-(3,3'-bi[1,2,4-oxa-diazole]-5,5'-di-yl)bis-(1 H -tetra-zol-1-olate), with the following cations: hydrazinium ( 1 ) (2N2 H5 + ·C6 N12 O4 2- ), hydroxyl-ammonium ( 2 ) 2NH4 O+ ·C6 N12 O4 2- [Pagoria et al...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29762776/commentary-neurological-surgery-at-vanderbilt-university-1873-to-present
#3
Patrick D Kelly, Scott L Zuckerman, Lola B Chambless, Timothy P Schoettle, John C Wellons, Reid C Thompson
No abstract text is available yet for this article.
May 12, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29754852/predictors-of-survival-after-yttrium-90-radioembolization-for-colorectal-cancer-liver-metastases
#4
Ashley A Weiner, Bin Gui, Neil B Newman, John L Nosher, Fady Yousseff, Shou-En Lu, Gretchen M Foltz, Darren Carpizo, Jonathan Lowenthal, Darryl A Zuckerman, Ben Benson, Jeffrey R Olsen, Salma K Jabbour, Parag J Parikh
PURPOSE: To identify clinical parameters that are prognostic for improved overall survival (OS) after yttrium-90 radioembolization (RE) in patients with liver metastases from colorectal cancer (CRC). MATERIALS AND METHODS: A total of 131 patients who underwent RE for liver metastases from CRC, treated at 2 academic centers, were reviewed. Twenty-one baseline pretreatment clinical factors were analyzed in relation to OS by the Kaplan-Meier method along with log-rank tests and univariate and multivariate Cox regression analyses...
May 10, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29752174/a-prospective-birth-cohort-study-on-early-childhood-lead-levels-and-attention-deficit-hyperactivity-disorder-new-insight-on-sex-differences
#5
Yuelong Ji, Xiumei Hong, Guoying Wang, Nilanjan Chatterjee, Anne W Riley, Li-Ching Lee, Pamela J Surkan, Tami R Bartell, Barry Zuckerman, Xiaobin Wang
OBJECTIVE: To investigate the prospective associations between early childhood lead exposure and subsequent risk of attention deficit hyperactivity disorder (ADHD) in childhood and its potential effect modifiers. STUDY DESIGN: We analyzed data from 1479 mother-infant pairs (299 ADHD, 1180 neurotypical) in the Boston Birth Cohort. The child's first blood lead measurement and physician-diagnosed ADHD was obtained from electronic medical records. Graphic plots and multiple logistic regression were used to examine dose-response associations between lead exposure and ADHD and potential effect modifiers, adjusting for pertinent covariables...
May 8, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29742129/a-snapshot-of-translational-research-funded-by-the-national-institutes-of-health-nih-a-case-study-using-behavioral-and-social-science-research-awards-and-clinical-and-translational-science-awards-funded-publications
#6
Xueying Han, Sharon R Williams, Brian L Zuckerman
The translation of biomedical research from basic knowledge to application has been a priority at the National Institute of Health (NIH) for many years. Tracking the progress of scientific research and knowledge through the translational process is difficult due to variation in the definition of translational research as well as the identification of benchmarks for the spread and application of biomedical research; quantitatively tracking this process is even more difficult. Using a simple and reproducible method to assess whether publications are translational, we examined NIH R01 behavioral and social science research (BSSR) awards funded between 2008 and 2014 to determine whether there are differences in the percent of translational research publications produced by basic and applied research awards...
2018: PloS One
https://www.readbyqxmd.com/read/29738043/complement-activation-in-atypical-hemolytic-uremic-syndrome-and-scleroderma-renal-crisis-a-critical-analysis-of-pathophysiology
#7
Roman Zuckerman, Arif Asif, Eric J Costanzo, Tushar Vachharajani
Scleroderma is an autoimmune disease that affects multiple systems. While pathophysiologic mechanisms governing the development of scleroderma are relatively poorly understood, advances in our understanding of the complement system are clarifying the role of complement pathways in the development of atypical hemolytic uremic syndrome and scleroderma renal crisis. The abundant similarities in their presentation as well as the clinical course are raising the possibility of a common underlying pathogenesis. Recent reports are emphasizing that complement pathways appear to be the unifying link...
May 7, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29738027/hydralazine-associated-adverse-events-a-report-of-two-cases-of-hydralazine-induced-anca-vasculitis
#8
Roman Zuckerman, Mayurkumar Patel, Eric J Costanzo, Harry Dounis, Rany Al Haj, Seyedehsara Seyedali, Arif Asif
Hydralazine is a direct-acting vasodilator, which has been used in treatment for hypertension (HTN) since the 1950s. While it is well known to cause drug-induced lupus (DIL), recent reports are indicating the emergence of the drug-induced anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (DIV). Herein, we describe two patients (aged 57 and 87 years) who presented with severe acute kidney injury (AKI), proteinuria, and hematuria. Both were receiving hydralazine for the treatment of hypertension...
May 7, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29710216/association-of-dasatinib-with-progression-free-survival-among-patients-with-advanced-gastrointestinal-stromal-tumors-resistant-to-imatinib
#9
Scott M Schuetze, Vanessa Bolejack, Dafydd G Thomas, Margaret von Mehren, Shreyaskumar Patel, Brian Samuels, Edwin Choy, Gina D'Amato, Arthur P Staddon, Kristen N Ganjoo, Warren A Chow, Daniel A Rushing, Charles A Forscher, Dennis A Priebat, David M Loeb, Rashmi Chugh, Scott Okuno, Denise K Reinke, Laurence H Baker
Importance: Gastrointestinal stromal tumors (GISTs) are life-threatening when metastatic or not amenable to surgical removal. In a few patients with advanced GISTs refractory to imatinib mesylate, treatment with sunitinib malate followed by regorafenib provides tumor control; however, additional active treatments are needed for most patients. Objective: To evaluate the 6-month progression-free survival (PFS), tumor objective response, and overall survival rates in patients with GISTs treated with dasatinib...
April 26, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29700707/parent-perceptions-of-community-autism-spectrum-disorder-stigma-measure-validation-and-associations-in-a-multi-site-sample
#10
Katharine E Zuckerman, Olivia J Lindly, Nuri M Reyes, Alison E Chavez, Maritza Cobian, Kristy Macias, Ann M Reynolds, Kathryn A Smith
In this study we developed a brief, English/Spanish bilingual parent-reported scale of perceived community autism spectrum disorder (ASD) stigma and tested it in a multi-site sample of Latino and non-Latino white parents of children with ASD. Confirmatory factor analysis of the scale supported a single factor solution with 8 items showing good internal consistency. Regression modeling suggested that stigma score was associated with unmet ASD care needs but not therapy hours or therapy types. Child public insurance, parent nativity, number of children with ASD in the household, parent-reported ASD severity, and family structure, were associated with higher stigma score...
April 26, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29686764/a-comparison-of-assessment-tools-is-direct-observation-an-improvement-over-objective-structured-clinical-examinations-for-communications-skills-evaluation
#11
Abraham M Goch, Raj Karia, David Taormina, Adina Kalet, Joseph Zuckerman, Kenneth A Egol, Donna Phillips
Background : Evaluation of resident physicians' communications skills is a challenging task and is increasingly accomplished with standardized examinations. There exists a need to identify the effective, efficient methods for assessment of communications skills. Objective : We compared objective structured clinical examination (OSCE) and direct observation as approaches for assessing resident communications skills. Methods : We conducted a retrospective cohort analysis of orthopaedic surgery resident physicians at a single tertiary care academic institution, using the Institute for Healthcare Communication "4 Es" model for effective communication...
April 2018: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29682694/the-american-society-of-hematology-ash-medical-educators-institute-a-pilot-faculty-development-project-for-hematology-educators
#12
Jennifer C Kesselheim, Charles P Clayton, Josel Fritz, Roy E Smith, Scott D Gitlin, Erin Reid, Kenneth S Zuckerman, Marc J Kahn
Clinician educators at academic medical centers often lack the community, mentorship, and faculty development to support their missions around education scholarship and teaching. Inadequate support for clinician educators can lead to professional dissatisfaction and slowed academic advancement. In 2014, ASH conducted a needs assessment of medical school hematology course directors, hematology-oncology fellowship program directors, and other ASH members identified as educators to determine this community's desire for faculty development in medical education...
April 22, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29673146/predictors-of-response-to-ketamine-in-treatment-resistant-major-depressive-disorder-and-bipolar-disorder
#13
Carola Rong, Caroline Park, Joshua D Rosenblat, Mehala Subramaniapillai, Hannah Zuckerman, Dominika Fus, Yena L Lee, Zihang Pan, Elisa Brietzke, Rodrigo B Mansur, Danielle S Cha, Leanna M W Lui, Roger S McIntyre
OBJECTIVES: Extant evidence indicates that ketamine exerts rapid antidepressant effects in treatment-resistant depressive (TRD) symptoms as a part of major depressive disorder (MDD) and bipolar disorder (BD). The identification of depressed sub-populations that are more likely to benefit from ketamine treatment remains a priority. In keeping with this view, the present narrative review aims to identify the pretreatment predictors of response to ketamine in TRD as part of MDD and BD. METHOD: Electronic search engines PubMed/MEDLINE, ClinicalTrials...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29672150/folate-nutrition-status-in-mothers-of-the-boston-birth-cohort-sample-of-a-us-urban-low-income-population
#14
Tina L Cheng, Kamila B Mistry, Guoying Wang, Barry Zuckerman, Xiaobin Wang
OBJECTIVES: To examine maternal folic acid supplementation and plasma folate concentrations in the Boston Birth Cohort, a predominantly urban, low-income, minority population in Boston, Massachusetts. METHODS: This report includes 7612 mothers with singleton live births (3829 Black, 2023 Hispanic, 865 White, and 895 others) enrolled in the Boston Birth Cohort at the Boston Medical Center, during 1999 to 2014. Folic acid supplementation during preconception and each trimester was obtained via interview questionnaire...
April 19, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29665000/increased-killer-b-cells-in-chronic-hcv-infection-may-lead-to-autoimmunity-and-increased-viral-load
#15
Nasren Eiza, Eli Zuckerman, Matthias Carlebach, Tova Rainis, Yair Goldberg, Zahava Vadasz
BACKGROUND: B regulatory (Breg) cells are characterized by various membrane markers, and the secretion of different inhibitory cytokines. A new subset of Breg cells was identified as CD5hi Fas-ligand (FasL)hi. Their main reported role is to suppress anti-viral and anti-tumor immune responses and hence, they have been dubbed "killer" B cells. In this study, we aim to assess the role of these cells in chronic hepatitis C virus (HCV) infection, and determine if they contribute to the increased viral load and persistence of HCV and its related autoimmunity...
April 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29660594/methodological-factors-as-a-potential-source-of-discordance-between-self-report-and-behavioral-measures-of-impulsivity-and-related-constructs
#16
Jarrod M Ellingson, Marc N Potenza, Godfrey D Pearlson
There is a consistent but poorly understood finding that self-report and behavioral measures of impulsivity are weakly correlated or uncorrelated. There are many possible explanations for this observation, including differences in how these instruments are administered and scored. The present study examined the utility of alternative scoring algorithms for self-report measures that aim to identify participants' peak impulsivity (or self-control), informed by estimates of item difficulty from Item Response Theory (IRT) analyses...
April 9, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29660050/in-reply-incidence-and-predictive-factors-of-sepsis-following-adult-spinal-deformity-surgery
#17
Scott L Zuckerman, Nikita Lakomkin, Constantinos G Hadjipanayis, Christopher I Shaffrey, Justin S Smith, Joseph S Cheng
No abstract text is available yet for this article.
April 4, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29657439/topical-vancomycin-and-its-effect-on-survival-and-migration-of-osteoblasts-fibroblasts-and-myoblasts-an-in-vitro-study
#18
James X Liu, Dalibel Bravo, John Buza, Thorsten Kirsch, Oran Kennedy, Andrew Rokito, Joseph D Zuckerman, Mandeep S Virk
The purpose of this study was to examine the influence of topical vancomycin on cell migration and survival of tissue healing cells. Human osteoblasts, myoblasts and fibroblasts were exposed to vancomycin at concentrations of 1, 3, 6, or 12 mg/cm2 for either a 1-h or 48-h (continuous) duration. Continuous exposure to all vancomycin concentrations significantly reduced cell survival (<22% cells survived) and migration in osteoblasts and myoblasts (P < 0.001). 1-h vancomycin exposure reduced osteoblast and myoblast survival and migration only at 12 mg/cm2 (P < 0...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29649367/religion-as-an-exchange-system-the-interchangeability-of-god-and-government-in-a-provider-role
#19
Miron Zuckerman, Chen Li, Ed Diener
An exchange model of religion implies that if a secular entity such as government provides what people need, they will be less likely to seek help from supernatural entities. Controlling for quality of life and income inequality (Gini), we found that better government services were related to lower religiosity among countries (Study 1) and states in the United States (Study 2). Study 2 also showed that during 2008-2013, better government services in a specific year predicted lower religiosity 1 to 2 years later...
April 1, 2018: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29627349/recurrent-ethylene-glycol-poisoning-with-elevated-lactate-levels-to-obtain-opioid-medications
#20
Matthew Zuckerman, Tim Vo
BACKGROUND: Malingering is when a patient feigns illness for secondary gain. While most patients with malingering manufacture or exaggerate symptoms, some patients may induce illness. Previous reports of malingering patients inducing illness include sepsis, kidney pain, migraine, and chest pain. However, acute poisoning as a manifestation of malingering appears to be rare. CASE REPORT: We describe the case of a 39-year-old man who presented to the emergency department complaining of diffuse body pain...
April 4, 2018: Journal of Emergency Medicine
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