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https://www.readbyqxmd.com/read/28643529/correlation-between-adenoma-detection-rate-and-novel-quality-indicators-for-screening-colonoscopy-a-proposal-for-quality-measures-tool-kit
#1
Mohamed M Abdelfatah, Sherif Elhanafi, Marc J Zuckerman, Mohamed O Othman
BACKGROUND AND AIMS: Adenoma detection rate (ADR) is the most validated quality indicator for colonoscopy. Calculating ADR may not yield information in regards to advanced adenoma detection rate (advanced ADR). In addition, calculating ADR for individual endoscopists cannot distinguish between those who find only one versus more than one adenoma per colonoscopy. Several novel quality indictors were recently proposed to ensure adequate assessment of quality during colonoscopy. Our study aims to determine the correlation between ADR and novel quality indicators...
June 23, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28639339/advancing-the-field-of-anti-hla-sensitization-management-prior-to-pediatric-heart-transplantation
#2
EDITORIAL
Warren A Zuckerman
No abstract text is available yet for this article.
June 22, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28637791/store-operated-calcium-entry-suppressed-tgf%C3%AE-1-smad3-signaling-pathway-in-glomerular-mesangial-cells
#3
Sarika Chaudhari, Weizu Li, Yanxia Wang, Hui Jiang, Yuhong Ma, Mark E Davis, Jonathan E Zuckerman, Rong Ma
Our previous study demonstrated that the abundance of extracellular matrix proteins was suppressed by store-operated Ca2+ entry in mesangial cells (MCs). The present study was conducted to investigate the underlying mechanism focused on the transforming growth factor beta 1 (TGFβ1) - Smad3 pathway, a critical pathway for ECM expansion in diabetic kidneys. We hypothesized that SOCE suppressed ECM protein expression by inhibiting this pathway in MCs. In cultured human MCs, we observed that TGFβ1 (5 ng/ml for 15 hours) significantly increased Smad3 phosphorylation as evaluated by immunoblot...
June 21, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28635297/medical-students-leading-quality-improvement-a-lean-six-sigma-approach-to-pain-management
#4
David Droullard, Samuel Porter, Anna Zuckerman, Daphne Monie, Judi Brendle, Henry Weil
No abstract text is available yet for this article.
June 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28619439/origin-prevalence-and-response-to-therapy-of-hepatitis-c-virus-genotype-2k-1b-chimeras
#5
Simone Susser, Julia Dietz, Bernhard Schlevogt, Eli Zuckerman, Mira Barak, Valeria Piazzolla, Anita Howe, Holger Hinrichsen, Sandra Passmann, Rasha Daniel, Markus Cornberg, Alessandra Mangia, Stefan Zeuzem, Christoph Sarrazin
BACKGROUND & AIMS: Little is known about the epidemiology and frequency of recombinant HCV genotype 2/1 strains which may represent a challenge for direct antiviral therapy (DAA). METHODS: Consecutive samples from HCV genotype 2 infected patients from Germany, Italy and Israel according to commercial genotyping were re-genotyped by Sanger-based sequencing. Virologic, epidemiological, and phylogenetic analyses including other published chimeras were performed. RESULTS: Sequence analysis of 442 supposed HCV genotype 2 isolates revealed 61 (genotype 2k/1b (n=59), 2a/1b (n=1) or 2b/1a (n=1)) chimeras...
June 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28598419/genome-wide-approach-identifies-a-novel-gene-maternal-pre-pregnancy-bmi-interaction-on-preterm-birth
#6
Xiumei Hong, Ke Hao, Hongkai Ji, Shouneng Peng, Ben Sherwood, Antonio Di Narzo, Hui-Ju Tsai, Xin Liu, Irina Burd, Guoying Wang, Yuelong Ji, Deanna Caruso, Guangyun Mao, Tami R Bartell, Zhongyang Zhang, Colleen Pearson, Linda Heffner, Sandra Cerda, Terri H Beaty, M Daniele Fallin, Aviva Lee-Parritz, Barry Zuckerman, Daniel E Weeks, Xiaobin Wang
Preterm birth (PTB) contributes significantly to infant mortality and morbidity with lifelong impact. Few robust genetic factors of PTB have been identified. Such 'missing heritability' may be partly due to gene × environment interactions (G × E), which is largely unexplored. Here we conduct genome-wide G × E analyses of PTB in 1,733 African-American women (698 mothers of PTB; 1,035 of term birth) from the Boston Birth Cohort. We show that maternal COL24A1 variants have a significant genome-wide interaction with maternal pre-pregnancy overweight/obesity on PTB risk, with rs11161721 (PG × E=1...
June 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28597355/minimal-device-encrustation-on-vesair-intravesical-balloons-in-the-treatment-of-stress-urinary-incontinence-analysis-of-balloons-removed-from-women-in-the-solect-trial
#7
Gommert A van Koeveringe, Stefan De Wachter, Jack M Zuckerman, Giovanni Tommaselli, Michel J de Wildt, Karel C M Everaert, Dirk P J Michielsen, Jean-Jacques Wyndaele
INTRODUCTION: Encrustation of urinary biomaterials is common; however, the incidence of surface deposition on the Vesair(®) intravesical pressure-attenuation balloon has not been previously reported. The purpose of this analysis is to determine the incidence and potential risk factors for encrustation of the Vesair intravesical balloon. METHODS: The SOLECT trial is a prospective randomized controlled trial conducted at several European centers to evaluate the safety and efficacy of the Vesair balloon for the treatment of female stress urinary incontinence (SUI)...
June 9, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28588647/an-update-on-best-practice-in-the-diagnosis-and-management-of-post-prostatectomy-anastomotic-strictures
#8
REVIEW
Nicholas R Rocco, Jack M Zuckerman
Postprostatectomy vesicourethral anastomotic stenosis (VUAS) remains a challenging problem for both patient and urologist. Improved surgical techniques and perioperative identification and treatment of risk factors has led to a decline over the last several decades. High-level evidence to guide management is lacking, primarily relying on small retrospective studies and expert opinion. Endourologic therapies, including dilation and transurethral incision or resection with or without adjunct injection of scar modulators is considered first-line management...
October 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/28579360/complications-of-long-and-intermediate-term-venous-catheters-in-cystic-fibrosis-patients-a-multicenter-study
#9
Teresa L May, Alex H Gifford, Thomas Lahiri, Adam Black, Janet Trang, Alexandra G Cornell, Karyll Gonzalez, Scott Morin, Mark Napier, Christine W Duarte, Jonathan B Zuckerman
BACKGROUND: Totally implantable venous access devices (TIVADs) or peripherally inserted central venous catheters (PICCs) are commonly used in the care of patients with cystic fibrosis (CF), but they are associated with various complications, including thrombosis, infection, and insertion site symptoms. METHODS: We conducted a retrospective review of PICC and TIVAD use in adults and children with CF over an 8-year period at 3 accredited care centers. Patient attributes included CFTR genotype, comorbidities, lung function, body mass index, use of anticoagulation, and respiratory tract microbiology...
June 1, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28557734/disparities-in-diagnosis-and-treatment-of-autism-in-latino-and-non-latino-white-families
#10
Katharine E Zuckerman, Olivia J Lindly, Nuri M Reyes, Alison E Chavez, Kristy Macias, Kathryn N Smith, Ann Reynolds
OBJECTIVES: To compare barriers to autism spectrum disorder (ASD) diagnosis and current ASD-related service use among non-Latino white (NLW) families and Latino families with English proficiency (L-EP) or limited English proficiency (L-LEP). METHODS: We conducted a mixed-mode survey of families of children with confirmed ASD seen at specialty clinics in 3 United States cities. Bivariate and multivariate analyses compared barriers to ASD diagnosis, current service use, and unmet therapy need among NLW, L-EP, and L-LEP families...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28520635/decreasing-disparities-in-child-development-assessment-identifying-and-discussing-possible-delays-in-the-special-supplemental-nutrition-program-for-women-infants-and-children-wic
#11
Katharine E Zuckerman, Alison E Chavez, Julie A Reeder
OBJECTIVE: To assess how staff at the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) address potential developmental delays and parent developmental concerns in children <5 years. METHODS: A Web-based survey of Oregon WIC staff in nonadministrative roles assessed staff interactions with parents regarding concerning child development/behavior, perceptions of connectedness with local developmental resources, and knowledge of typical child development...
June 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28506982/social-risk-factors-and-performance-under-medicare-s-value-based-purchasing-programs
#12
Karen E Joynt, Rachael Zuckerman, Arnold M Epstein
No abstract text is available yet for this article.
May 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28505031/povidone-iodine-solutions-inhibit-cell-migration-and-survival-of-osteoblasts-fibroblasts-and-myoblasts
#13
James X Liu, Jordan A Werner, John A Buza, Thorsten Kirsch, Joseph D Zuckerman, Mandeep S Virk
STUDY DESIGN: In vitro laboratory study. OBJECTIVE: The purpose of this study was to identify the effect of dilute povidone-iodine (PVI) solutions on human osteoblast, fibroblast and myoblast cells in vitro. SUMMARY OF BACKGROUND DATA: Dilute PVI wound lavage has been used successfully in spine and joint arthroplasty procedures to prevent post-operative surgical site infection, but their biologic effect on host cells is largely unknown. METHODS: Human primary osteoblasts, fibroblasts, and myoblasts were expanded in cell culture and subjected to various concentrations of PVI (0%, 0...
April 12, 2017: Spine
https://www.readbyqxmd.com/read/28498938/healthcare-resource-utilization-and-patient-reported-outcomes-following-elective-surgery-for-intradural-extramedullary-spinal-tumors
#14
Silky Chotai, Scott L Zuckerman, Scott L Parker, Joseph B Wick, David P Stonko, Andrew T Hale, Matthew J McGirt, Joseph S Cheng, Clinton J Devin
BACKGROUND: Healthcare resource utilization and patient-reported outcomes (PROs) for intradural extramedullary (IDEM) spine tumors are not well reported. OBJECTIVE: To analyze the PROs, costs, and resource utilization 1 year following surgical resection of IDEM tumors. METHODS: Patients undergoing elective spine surgery for IDEM tumors and enrolled in a single-center, prospective, longitudinal registry were analyzed. Baseline and postoperative 1-year PROs were recorded...
May 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28495447/characterization-of-gene-expression-associated-with-the-adaptation-of-the-nematode-c-elegans-to-hypoxia-and-reoxygenation-stress-reveals-an-unexpected-function-of-the-neuroglobin-glb-5-in-innate-immunity
#15
Binyamin Zuckerman, Zohar Abergel, Veronica Zelmanovich, Leonor Romero, Rachel Abergel, Leonid Livshits, Yoav Smith, Einav Gross
Oxygen (O2) is a double-edged sword to cells, for while it is vital for energy production in all aerobic animals and insufficient O2 (hypoxia) can lead to cell death, the reoxygenation of hypoxic tissues may trigger the generation of reactive oxygen species (ROS) that can destroy any biological molecule. Indeed, both hypoxia and hypoxia-reoxygenation (H/R) stress are harmful, and may play a critical role in the pathophysiology of many human diseases, such as myocardial ischemia and stroke. Therefore, understanding how animals adapt to hypoxia and H/R stress is critical for developing better treatments for these diseases...
May 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28483174/-impact-of-a-multimodal-intervention-on-the-psychological-profile-of-schizophrenic-and-bipolar-i-patients-a-study-of-prisma-program
#16
Ana María Díaz-Zuluaga, Cristian Vargas, Kelly Duica, Shanel Richard, Juan David Palacio, Yuli Agudelo Berruecos, Sigifredo Ospina, Carlos López-Jaramillo
BACKGROUND: Bipolar Disorder (BD) and schizophrenia are included in the group of severe mental illness and are main causes of disability and morbidity in the local population due to the bio-psycho-social implications in patients. In the last 20 years or so, adjunctive psychological interventions been studied with the purpose of decreasing recurrences, stabilising the course of the disease, and improving the functionality in these patients. OBJECTIVE: To analyse the psychological effect of a multimodal intervention (MI) vs a traditional intervention (TI) program in BD I and schizophrenic patients...
April 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28480525/real-world-effectiveness-of-ombitasvir-paritaprevir-ritonavir-%C3%A2-dasabuvir-%C3%A2-ribavirin-in-patients-with-hcv-genotype-1-or-4-infection-a-meta-analysis
#17
Heiner Wedemeyer, Antonio Craxí, Eli Zuckerman, Douglas Dieterich, Robert Flisiak, Stuart K Roberts, Andreas Pangerl, Zhenzhen Zhang, Marisol Martinez, Yanjun Bao, José-Luis Calleja
The direct-acting antiviral regimen of ombitasvir (OBV)/paritaprevir (PTV)/ritonavir (r) ± dasabuvir (DSV) ± ribavirin (RBV) demonstrated high rates of sustained viral response at post-treatment week 12 (SVR12) in clinical trials for treatment of hepatitis C virus (HCV) genotypes (GT) 1 and 4. To confirm the effectiveness of this regimen in the real world, we conducted meta-analyses of published literature on 30 April 2016. Freeman-Tukey transformation determined the SVR rate within GTs 1a, 1b, and 4, as well as specific SVR rates by cirrhosis or prior treatment experience status...
May 8, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28463917/conversion-to-reverse-total-shoulder-arthroplasty-with-and-without-humeral-stem-retention-the-role-of-a-convertible-platform-stem
#18
Lynn A Crosby, Thomas W Wright, Stephen Yu, Joseph D Zuckerman
BACKGROUND: Revision shoulder arthroplasty is a technically challenging procedure. It is associated with increased blood loss and operative time, and it frequently necessitates revision implants, augments, and bone-grafting. Shoulder arthroplasty systems with a convertible-platform humeral stem have been developed to reduce the complexity of revision procedures by eliminating the need for humeral component explantation when converting from anatomic shoulder arthroplasty (hemiarthroplasty or total shoulder arthroplasty) to reverse total shoulder arthroplasty (rTSA)...
May 3, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28463546/imaging-with-synthesized-2d-mammography-differences-advantages-and-pitfalls-compared-with-digital-mammography
#19
Samantha P Zuckerman, Andrew D A Maidment, Susan P Weinstein, Elizabeth S McDonald, Emily F Conant
OBJECTIVE: Synthesized 2D (s2D) mammography is rapidly replacing digital mammography in breast imaging with digital breast tomosynthesis (DBT) to reduce radiation dose and maintain screening outcomes. We illustrate variations in the appearance of s2D and digital mammograms to aid in implementation of this technology. CONCLUSION: Despite subjective differences in the appearance of s2D and digital mammograms, early outcomes of screening using s2D mammography and DBT are not inferior to those achieved with digital mammography and DBT...
May 2, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28450351/prospective-study-of-adenosine-on-atrioventricular-nodal-conduction-in-pediatric-and-young-adult-patients-after-heart-transplant
#20
Jonathan N Flyer, Warren A Zuckerman, Marc E Richmond, Brett R Anderson, Tamar G Mendelsberg, Jennie M McAllister, Leonardo Liberman, Linda J Addonizio, Eric S Silver
Background -Supraventricular tachycardia (SVT) is common after heart transplant. Adenosine, the standard therapy for treating SVT in children and adults without transplant, is relatively contraindicated post-transplant due to a presumed risk of prolonged atrioventricular (AV) block in denervated hearts. This study tested whether adenosine caused prolonged asystole after transplant and if it was effective in blocking AV nodal conduction in these patients. Methods -This was a single center prospective clinical study including healthy heart transplant recipients ages 6 months - 25 years presenting for routine cardiac catheterization during 2015 - 2016...
April 27, 2017: Circulation
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