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https://www.readbyqxmd.com/read/28938749/the-testicular-transcriptome-associated-with-spermatogonia-differentiation-initiated-by-gonadotrophin-stimulation-in-the-juvenile-rhesus-monkey-macaca-mulatta
#1
Suresh Ramaswamy, William H Walker, Paula Aliberti, Rahil Sethi, Gary R Marshall, Alyxzandria Smith, Seyedmehdi Nourashrafeddin, Alicia Belgorosky, Uma R Chandran, Mark P Hedger, Tony M Plant
STUDY QUESTION: What is the genetic landscape within the testis of the juvenile rhesus monkey (Macaca mulatta) that underlies the decision of undifferentiated spermatogonia to commit to a pathway of differentiation when puberty is induced prematurely by exogenous LH and FSH stimulation? SUMMARY ANSWER: Forty-eight hours of gonadotrophin stimulation of the juvenile monkey testis resulted in the appearance of differentiating B spermatogonia and the emergence of 1362 up-regulated and 225 down-regulated testicular mRNAs encoding a complex network of proteins ranging from enzymes regulating Leydig cell steroidogenesis to membrane receptors, and from juxtacrine and paracrine factors to transcriptional factors governing spermatogonial stem cell fate...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28918386/evaluation-of-previously-embolized-intracranial-aneurysms-inter-and-intra-rater-reliability-among-neurosurgeons-and-interventional-neuroradiologists
#2
Scott L Zuckerman, Nikita Lakomkin, Jordan A Magarik, Jan Vargas, Marcus Stephens, Babatunde Akinpelu, Alejandro M Spiotta, Azam Ahmed, Adam S Arthur, David Fiorella, Ricardo Hanel, Joshua A Hirsch, Ferdinand K Hui, Robert F James, David F Kallmes, Philip M Meyers, David B Niemann, Peter Rasmussen, Raymond D Turner, Babu G Welch, J Mocco
BACKGROUND: The angiographic evaluation of previously coiled aneurysms can be difficult yet remains critical for determining re-treatment. OBJECTIVE: The main objective of this study was to determine the inter-rater reliability for both the Raymond Scale and per cent embolization among a group of neurointerventionalists evaluating previously embolized aneurysms. METHODS: A panel of 15 neurointerventionalists examined 92 distinct cases of immediate post-coil embolization and 1 year post-embolization angiographs...
September 16, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28905883/acceptable-applications-of-preimplantation-genetic-diagnosis-pgd-among-israeli-pgd-users
#3
Shachar Zuckerman, David A Zeevi, Sigal Gooldin, Gheona Altarescu
The use of PGD technology to select against genetic disorders and traits is increasing. Although PGD may eliminate some of the obstacles related to conservative options of prenatal diagnosis, it can raise personal, social and moral questions. Ethical issues concerning the justified uses of PGD are a subject of ongoing debate among medical and bioethical communities. Although attitudes toward the acceptable uses of PGD were evaluated among population groups worldwide, bioethics councils were criticized for ignoring public perspectives...
October 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28903693/societal-conditions-and-the-gender-difference-in-well-being-testing-a-three-stage-model
#4
Miron Zuckerman, Chen Li, Edward F Diener
Findings from a meta-analysis on gender differences in self-esteem (Zuckerman et al., 2016) suggest that the relation between the degree to which societal conditions are favorable to women and gender difference in self-esteem might be quadratic; when conditions improve, women's self-esteem (relative to that of men) trends downward but when conditions continue to improve, women's self-esteem begins to trend upward. Testing whether these relations generalize to subjective well-being, the present study found a quadratic relation between improving societal conditions and the gender difference in life satisfaction and positive affect (women are lower than men when societal conditions are moderately favorable compared to when they are at their worst and at their best); the relation was linear for negative emotion (women report more negative emotions than men when societal conditions are better)...
March 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28902601/impact-of-diabetes-on-perioperative-complications-in-patients-undergoing-elective-total-shoulder-arthroplasty
#5
Siddharth Mahure, Brent Mollon, Mary Quien, Raj Karia, Joseph Zuckerman, Young Kwon
INTRODUCTION: Diabetes has been associated with negative outcomes following orthopaedic surgery. While previous studies have reported on diabetes-associated complications in shoulder arthroplasty, those cohorts were heterogeneous in terms of patient population, nature of elective surgery, and arthroplasty type. Given that the number of elective total shoulder arthroplasties (TSAs) performed has grown substantially in volume and is predicted to rise even further, it is important to recognize the role that diabetes may play in developing in-hospital complications within a more homogenous sample of patients undergoing elective TSA...
May 2017: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/28902595/patent-foramen-ovale-after-cryptogenic-stroke-assessing-the-evidence-for-closure
#6
Andrew Farb, Nicole G Ibrahim, Bram D Zuckerman
The Amplatzer PFO Occluder was approved by the Food and Drug Administration (FDA) on October 28, 2016. The device is indicated for percutaneous transcatheter closure of a patent foramen ovale to reduce the risk of recurrent ischemic stroke in patients who’ve had a cryptogenic stroke that a..
September 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28901423/a-multi%C3%A2-targeted-tyrosine-kinase-inhibitor-lenvatinib-for-the-treatment-of-mice-with-advanced-glioblastoma
#7
Jia Li, Chang-Lin Zou, Zhi-Ming Zhang, Lian-Jie Lv, Hai-Bo Qiao, Xiu-Ju Chen
Glioblastoma is the most aggressive primary brain tumor that originates from the glial cells in adults. Aberrant angiogenesis is essential for malignant glioblastoma tumorigenesis, development and metastasis. Lenvatinib is a multi‑targeted anticancer agent that targets of receptor tyrosine kinases including vascular endothelial growth factor receptor 1 and 2, fibroblast growth factor receptor 1, platelet‑derived growth factor receptor β and v‑kit Hardy‑Zuckerman 4 feline sarcoma viral oncogene homolog...
September 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28899055/factors-associated-with-playing-through-a-sport-related-concussion
#8
Andrew W Kuhn, Scott L Zuckerman, Aaron M Yengo-Kahn, Zachary Y Kerr, Douglas J Totten, Kolin E Rubel, Allen K Sills, Gary S Solomon
No abstract text is available yet for this article.
September 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28898900/the-complications-of-vascular-access-in-hemodialysis
#9
Avais Masud, Eric J Costanzo, Roman Zuckerman, Arif Asif
No abstract text is available yet for this article.
September 12, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28895231/software-related-recalls-of-health-information-technology-and-other-medical-devices-implications-for-fda-regulation-of-digital-health
#10
Jay G Ronquillo, Diana M Zuckerman
Policy Points: Medical software has become an increasingly critical component of health care, yet the regulation of these devices is inconsistent and controversial. No studies of medical devices and software assess the impact on patient safety of the FDA's current regulatory safeguards and new legislative changes to those standards. Our analysis quantifies the impact of software problems in regulated medical devices and indicates that current regulations are necessary but not sufficient for ensuring patient safety by identifying and eliminating dangerous defects in software currently on the market...
September 2017: Milbank Quarterly
https://www.readbyqxmd.com/read/28888419/clinical-skills-and-professionalism-assessing-orthopaedic-residents-with-unannounced-standardized-patients
#11
David P Taormina, Joseph D Zuckerman, Raj Karia, Sondra Zabar, Kenneth A Egol, Donna P Phillips
OBJECTIVE: We developed a series of orthopedic unannounced standardized patient (USP) encounters for the purpose of objective assessment of residents during clinic encounters. DESIGN: Consecutive case-series. SETTING: NYU-Langone Multi-center Academic University Hospital System. PARTICIPANTS: NYU-Langone/Hospital for Joint Diseases Orthopedic Surgery residents; 48 consecutive residents assessed. METHODS: Four orthopedic cases were developed...
September 6, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28888271/clinical-event-adjudication-in-cardiovascular-device-trials-an-food-and-drug-administration-perspective
#12
EDITORIAL
Andrew Farb, Bram D Zuckerman
No abstract text is available yet for this article.
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28885304/bowel-preparations-administered-the-morning-of-colonoscopy-provide-similar-efficacy-to-a-split-dose-regimen-a-meta-analysis
#13
Danny J Avalos, Fernando J Castro, Marc J Zuckerman, Tara Keihanian, Andrew C Berry, Benjamin Nutter, Daniel A Sussman
BACKGROUND: Comparative efficacy of same-day bowel preparations for colonoscopy remains unclear. AIMS: A meta-analysis of randomized controlled trials comparing the efficacy of same-day versus split dose bowel preparations for colonoscopy. METHODS: A systematic search was conducted in MEDLINE, clinicaltrials.gov, Cochrane Registry, EMBASE, SCOPUS, Web of Science and CINAHL. Studies were gathered using keywords: "morning preparation", "morning bowel preparation", "same day bowel preparation", and "colonoscopy...
September 6, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28874495/sustained-gains-in-coverage-access-and-affordability-under-the-aca-a-2017-update
#14
Sharon K Long, Lea Bart, Michael Karpman, Adele Shartzer, Stephen Zuckerman
The significant gains in health insurance coverage and improvements in health care access and affordability that followed the implementation of the key coverage provisions of the Affordable Care Act in 2014 have persisted into 2017. Adults in all parts of the country, of all ages, and across all income groups have benefited from a large and sustained increase in the percentage of the US population that has health insurance. The gains have been particularly striking among low- and moderate-income Americans living in states that expanded Medicaid...
September 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28869184/the-treatment-landscape-of-myelofibrosis-before-and-after-ruxolitinib-approval
#15
Andrew T Kuykendall, Chetasi Talati, Najla Al Ali, Kendra Sweet, Eric Padron, David A Sallman, Jeffrey E Lancet, Alan F List, Kenneth S Zuckerman, Rami S Komrokji
INTRODUCTION/BACKGROUND: Myelofibrosis (MF) is a chronic myeloproliferative neoplasm that presents with a heterogeneous clinical phenotype and prognosis. Before the US Food and Drug Administration approval of ruxolitinib, treatment options were varied and had limited effect. The increased use of ruxolitinib has drastically altered the MF treatment landscape. In this study, we aimed to clarify the clinical situations in which ruxolitinib is being used and analyze its effect on this landscape...
August 5, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28860325/allogeneic-transplant-does-age-still-matter
#16
Tsila Zuckerman
No abstract text is available yet for this article.
August 31, 2017: Blood
https://www.readbyqxmd.com/read/28856924/review-of-current-typhoid-fever-vaccines-cross-protection-against-paratyphoid-fever-and-the-european-guidelines
#17
Jane N Zuckerman, Christoph Hatz, Anu Kantele
Typhoid and paratyphoid fever remain a global health problem, which - in non-endemic countries - are mainly seen in travelers, particularly in VFRs (visiting friends and relatives), with occasional local outbreaks occurring. A rise in anti-microbial resistance emphasizes the role of preventive measures, especially vaccinations against typhoid and paratyphoid fever for travelers visiting endemic countries. Areas covered: This state-of-the-art review recapitulates the epidemiology and mechanisms of disease of typhoid and paratyphoid fever, depicts the perspective of non-endemic countries and travelers (VFRs), and collectively presents current European recommendations for typhoid fever vaccination...
August 31, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28856350/is-simultaneous-bilateral-total-knee-arthroplasty-btka-as-safe-as-staged-btka
#18
Scott Hadley, Michael Day, Ran Schwarzkopf, Aaron Smith, James Slover, Joseph Zuckerman
Simultaneous bilateral total knee arthroplasty (BTKA) is often performed to treat patients with disabling arthritis of both knees. Its use compared with staged procedures remains controversial. In a retrospective study, we compared 371 patients who had simultaneous BTKA with 67 patients who had staged (<6 months apart) BTKA. The staged procedures fall within the crucial postoperative period when increased morbidity and mortality would more likely be present. Primary outcomes were perioperative complications, length of stay, and transfusion requirements...
July 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28854128/digital-health-communication-and-global-public-influence-a-study-of-the-ebola-epidemic
#19
Hal Roberts, Brittany Seymour, Sands Alden Fish, Emily Robinson, Ethan Zuckerman
Scientists and health communication professionals expressed frustration over the relationship between misinformation circulating on the Internet and global public perceptions of and responses to the Ebola epidemic originating in West Africa. Using the big data platform Media Cloud, we analyzed all English-language stories about keyword "Ebola" published from 1 July 2014 to 17 November 2014 from the media sets U.S. Mainstream Media, U.S. Regional Media, U.S. Political Blogs, U.S. Popular Blogs, Europe Media Monitor, and Global Voices to understand how social network theory and models of the networked global public may have contributed to health communication efforts...
2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28834787/transition-of-care-to-an-adult-provider
#20
Andrea L Zuckerman
PURPOSE OF REVIEW: The transition from adolescence to young adulthood can be a difficult and overwhelming time. Many adult care providers are unaware of the issues facing adolescents and young adults. Often the focus is on older patients and their problems. Internists, family practitioners and obstetricians and Gynecologists (OBGYNs) typically care for these patients. Often, young adults view their obstetrician and gynecologist as their primary care physician, so reviewing the issues facing this age group is important...
August 22, 2017: Current Opinion in Obstetrics & Gynecology
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