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https://www.readbyqxmd.com/read/29337133/cathodal-tdcs-of-the-bilateral-anterior-temporal-lobes-facilitates-semantically-driven-verbal-fluency
#1
Richard J Binney, Bonnie M Zuckerman, Hilary N Waller, Jinyi Hung, Sameer A Ashaie, Jamie Reilly
In a verbal fluency task, a person is required to produce as many exemplars of a given category (e.g., 'animals', or words starting with 'f') as possible within a fixed duration. Successful verbal fluency performance relies both on the depth of search within semantic/phonological neighborhoods ('clustering') and the ability to flexibly disengage between exhausted clusters ('switching'). Convergent evidence from functional imaging and neuropsychology suggests that cluster-switch behaviors engage dissociable brain regions...
January 11, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29317517/-the-talk-physician-version-special-considerations-for-african-american-male-adolescents
#2
Terry Maroney, Barry Zuckerman
No abstract text is available yet for this article.
January 9, 2018: Pediatrics
https://www.readbyqxmd.com/read/29306943/clinically-observed-estrogen-receptor-alpha-mutations-within-the-ligand-binding-domain-confer-distinguishable-phenotypes
#3
Shanhang Jia, Mark T Miedel, Marilyn Ngo, Ryan Hessenius, Ning Chen, Peilu Wang, Amir Bahreini, Zheqi Li, Zhijie Ding, Tong Ying Shun, Daniel M Zuckerman, D Lansing Taylor, Shannon L Puhalla, Adrian V Lee, Steffi Oesterreich, Andrew M Stern
OBJECTIVE: Twenty to fifty percent of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain. While most studies focused on the constitutive ER signaling activity commonly engendered by these mutations selected during estrogen deprivation therapy, our study was aimed at investigating distinctive phenotypes conferred by different mutations within this class. METHODS: We examined the two most prevalent mutations, D538G and Y537S, employing corroborative genome-edited and lentiviral-transduced ER+ T47D cell models...
January 6, 2018: Oncology
https://www.readbyqxmd.com/read/29305998/effects-of-mechanical-loading-on-cortical-defect-repair-using-a-novel-mechanobiological-model-of-bone-healing
#4
Chao Liu, Robert Carrera, Vittoria Flamini, Lena Kenny, Pamela Cabahug-Zuckerman, Benson M George, Daniel Hunter, Bo Liu, Gurpreet Singh, Philipp Leucht, Kenneth A Mann, Jill A Helms, Alesha B Castillo
Mechanical loading is an important aspect of post-surgical fracture care. The timing of load application relative to the injury event may differentially regulate repair depending on the stage of healing. Here, we used a novel mechanobiological model of cortical defect repair that offers several advantages including its technical simplicity and spatially confined repair program, making effects of both physical and biological interventions more easily assessed. Using this model, we showed that daily loading (5N peak load, 2Hz, 60 cycles, 4 consecutive days) during hematoma consolidation and inflammation disrupted the injury site and activated cartilage formation on the periosteal surface adjacent to the defect...
January 4, 2018: Bone
https://www.readbyqxmd.com/read/29298370/eradication-rate-of-helicobacter-pylori-on-the-us-mexico-border-using-the-urea-breath-test
#5
Roy P Liu, Roberta Romero, Jerzy Sarosiek, Christopher Dodoo, Alok K Dwivedi, Marc J Zuckerman
OBJECTIVES: Helicobacter pylori is prevalent worldwide, especially in Latin America. Triple and quadruple antibiotic therapies have been relatively effective; however, resistance has emerged in recent years. The treatment success rate of these regimens on the border of the United States and Mexico is unknown. Our study attempted to determine eradication rates of two major regimens based on urea breath test (UBT) results in patients previously diagnosed as having H. pylori in a single center in El Paso, Texas, a city on the geographic border with Mexico...
January 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29295472/a-prospective-birth-cohort-study-on-maternal-cholesterol-levels-and-offspring-attention-deficit-hyperactivity-disorder-new-insight-on-sex-differences
#6
Yuelong Ji, Anne W Riley, Li-Ching Lee, Heather Volk, Xiumei Hong, Guoying Wang, Rayris Angomas, Tom Stivers, Anastacia Wahl, Hongkai Ji, Tami R Bartell, Irina Burd, David Paige, Margaret D Fallin, Barry Zuckerman, Xiaobin Wang
Growing evidence suggests that maternal cholesterol levels are important in the offspring's brain growth and development. Previous studies on cholesterols and brain functions were mostly in adults. We sought to examine the prospective association between maternal cholesterol levels and the risk of attention deficit hyperactivity disorder (ADHD) in the offspring. We analyzed data from the Boston Birth Cohort, enrolled at birth and followed from birth up to age 15 years. The final analyses included 1479 mother-infant pairs: 303 children with ADHD, and 1176 neurotypical children without clinician-diagnosed neurodevelopmental disorders...
December 23, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29281103/incidence-and-predictive-factors-of-sepsis-following-adult-spinal-deformity-surgery
#7
Scott L Zuckerman, Nikita Lakomkin, Blaine P Stannard, Constantinos G Hadjipanayis, Christopher I Shaffrey, Justin S Smith, Joseph S Cheng
BACKGROUND: Surgery for adult spinal deformity (ASD) improves quality of life, yet morbidity is high. Sepsis is a challenging postoperative complication that can result in death and drive inpatient resources. OBJECTIVE: To identify the incidence and risk factors for development of sepsis within 30 days following ASD surgery. METHODS: Adult patients who underwent thoracolumbar spinal deformity correction between 2008 and 2014 were identified in the National Surgical Quality Improvement Program database...
December 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29280684/sport-related-concussive-convulsions-a-systematic-review
#8
Nicholas O Kuhl, Aaron M Yengo-Kahn, Hannah Burnette, Gary S Solomon, Scott L Zuckerman
OBJECTIVES: The incidence of sport-related concussion (SRC) continues to rise. Presentations of concussed athletes vary from subtle symptoms to notable signs. Between the 4th and 5th iterations of the Concussion in Sport Group (CISG) guidelines, concussive convulsions were removed as a modifying factor, but little evidence or discussion supported this change. While considerable research exists regarding post-traumatic epilepsy in moderate to severe traumatic brain injury, convulsions following SRC are relatively understudied...
December 27, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29279583/psychological-markers-underlying-murder-weapon-profile-a-quantitative-study
#9
M R Kamaluddin, A Othman, K H Ismail, G A Mat Saat
The horrific nature of murder using different types of weapons has been an important focal point of many criminological studies. Weapons that are used in murders seem to play dominant roles in murder investigations as they may provide information leading to arrest. The established factors for weapon usage include environmental context, demography and availability of weapons. However, there is insufficient research attention on the psychological functioning of murderers for particular weapon usage. In light of this, the current study seeks to narrow this gap of information by identifying the influences of psychological traits on weapon usage among a sample of male murderers...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29260638/advance-sling-use-decreasing-relative-to-artificial-urinary-sphincters
#10
Chad R Pusateri, Jack M Zuckerman
INTRODUCTION: To evaluate the percent of AdVance male sling usage relative to artificial urinary sphincters (AUS) over a 9 year period since its introduction in order to assess trends across the United States. MATERIALS AND METHODS: As a surrogate for procedures performed, we reviewed device utilization trends of the AdVance sling and AUS broken down by American Urological Association (AUA) section. ANOVA testing between years was used to determine purchasing trends with p values of < 0...
December 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29260220/chronic-traumatic-encephalopathy-in-football-players
#11
LETTER
Scott L Zuckerman, Benjamin L Brett, Aaron M Yengo-Kahn
No abstract text is available yet for this article.
December 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29245294/gastrointestinal-stromal-tumor-of-unusual-phenotype-after-imatinib-treatment-a-case-report-and-diagnostic-utility-of-etv1-mrna-in-situ-hybridization
#12
Minsun Jung, Sung-Hye Park, Yoon Kyung Jeon, Jae-Kyung Won, Han-Kwang Yang, Woo Ho Kim
RATIONALE: Gastrointestinal stromal tumor (GIST) is the most common tumor of mesenchymal origin in gastrointestinal tract. Immunohistochemical (IHC) staining combined with a typical morphology is used for the diagnosis of GIST. Typically, IHC staining for v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene (KIT) and discovered on GIST-1(DOG1) is positive in almost all GISTs. However, imatinib mesylate, a specific inhibitor of KIT tyrosine kinase, frequently involves changes in the morphology and IHC staining of GIST, impeding the diagnosis...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29243100/parents-use-of-complementary-health-approaches-for-young-children-with-autism-spectrum-disorder
#13
Olivia J Lindly, Sheryl Thorburn, Karen Heisler, Nuri M Reyes, Katharine E Zuckerman
Knowledge of why parents use complementary health approaches (CHA) for children with autism spectrum disorder (ASD) is limited. We conducted a mixed methods study to better understand factors influencing parents' decision to use CHA for ASD. Parent-reported data about CHA use were collected on a probability sample of 352 young children with ASD in Denver, Colorado; Los Angeles, California; or Portland, Oregon. Follow-back interviews were conducted with 31 parents. CHA use was negatively associated with older child age and positively associated with parents' belief ASD has major consequences, living in Portland or Denver, and medication use...
December 14, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29242710/retreatment-options-following-hcv-direct-acting-antiviral-failure
#14
Autumn Zuckerman, Cody A Chastain, Susanna Naggie
Despite the excellent efficacy of direct acting antivirals (DAA) for hepatitis C virus (HCV), treatment failures do occur. Until recently, retreatment decisions after DAA failure were influenced by the number of available agents, concerns about HCV drug resistance, and lack of data regarding retreatment. Recommended treatment approaches previously depended on limited clinical trials and expert opinion. In this article, we review the current state of the evidence for HCV retreatment after DAA failure. Based on recent clinical trial data, most patients who fail HCV treatment with DAA agents now have excellent retreatment options...
December 2017: Current Treatment Options in Infectious Diseases
https://www.readbyqxmd.com/read/29189896/between-a-rux-and-a-hard-place-evaluating-salvage-treatment-and-outcomes-in-myelofibrosis-after-ruxolitinib-discontinuation
#15
Andrew T Kuykendall, Savan Shah, Chetasi Talati, Najla Al Ali, Kendra Sweet, Eric Padron, David A Sallman, Jeffrey E Lancet, Alan F List, Kenneth S Zuckerman, Rami S Komrokji
Ruxolitinib is a JAK1/2 inhibitor that is effective in managing symptoms and splenomegaly related to myelofibrosis (MF). Unfortunately, many patients must discontinue ruxolitinib, at which time treatment options are not well defined. In this study, we investigated salvage treatment options and clinical outcomes among MF patients who received and discontinued ruxolitinib outside the context of a clinical trial. Among 145 patients who received ruxolitinib, 23 died while on treatment, 58 remained on treatment at time of analysis, leaving 64 people available for analysis...
November 30, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29185777/systematic-testing-of-belief-propagation-estimates-for-absolute-free-energies-in-atomistic-peptides-and-proteins
#16
Rory M Donovan-Maiye, Christopher J Langmead, Daniel Zuckerman
Motivated by the extremely high computing costs associated with estimates of free energies for biological systems using molecular simulations, we further the exploration of existing ``belief propagation'' (BP) algorithms for fixed-backbone peptide and protein systems. The pre-calculation of pairwise interactions among discretized libraries of side chain conformations, along with representation of protein side chains as nodes in a graphical model, enables direct application of the BP approach, which requires only $\sim$1 s of single-processor run time after the pre-calculation stage...
November 29, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29174240/predicting-resident-performance-from-pre-residency-factors-a-systematic-review-and-applicability-to-neurosurgical-training
#17
REVIEW
Scott L Zuckerman, Patrick D Kelly, Michael C Dewan, Peter J Morone, Aaron M Yengo-Kahn, Jordan A Magarik, Ronnie E Baticulon, Edie E Zusman, Gary S Solomon, John C Wellons
BACKGROUND: Neurosurgical educators strive to identify the best applicants, yet formal study of resident selection has proven difficult. We conducted a systematic review to answer the following question: what objective and subjective pre-residency factors predict resident success? METHODS: PubMed, ProQuest, Embase, and the CINAHL databases were queried from 1952-2015 for literature reporting the impact of pre-residency factors (PRF) on outcomes of residency success (RS), among neurosurgery and all surgical sub-specialties...
November 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29162305/quantifying-success-after-total-shoulder-arthroplasty-the-minimal-clinically-important-difference
#18
Ryan Simovitch, Pierre-Henri Flurin, Thomas Wright, Joseph D Zuckerman, Christopher P Roche
BACKGROUND: Knowledge of the minimal clinically important difference (MCID) for different shoulder outcome metrics and range of motion after total shoulder arthroplasty (TSA) can be useful to establish a minimum threshold of improvement that defines successful treatment. This study quantifies how MCID varies with different prosthesis types, patient age, gender, and length of follow-up after TSA. METHODS: A total of 466 anatomic TSA (aTSA) and reverse TSA (rTSA) with 2-year minimum follow-up were performed by 13 shoulder surgeons...
November 18, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29159032/use-of-ceftolozane-tazobactam-in-a-cystic-fibrosis-patient-with-multidrug-resistant-pseudomonas-infection-and-renal-insufficiency
#19
Katie Stokem, Jonathan B Zuckerman, David P Nicolau, Minkey Wungwattana, Edmund H Sears
We report the successful use of ceftolozane/tazobactam (C/T) to treat a pulmonary exacerbation in a 35 year old female, post lung transplant, with cystic fibrosis (CF), malnutrition, chronic kidney disease, and multi-drug resistant Pseudomonas aeruginosa infection (MDR PSA). Given the complexity of the clinical profile, we measured drug levels of C/T during treatment of her current exacerbation to determine pharmacokinetics. The patient achieved an estimated ceftolozane peak of 174.1 μg/mL and trough of 9...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29154933/opioid-prescription-and-patient-use-following-gynecologic-procedures-a-survey-of-patients-and-providers
#20
Kendall C Griffith, Nisse V Clark, Andrea L Zuckerman, Tanaz R Ferzandi, Kelly N Wright
STUDY OBJECTIVE: To describe opioid distribution and patient use following gynecologic procedures. DESIGN: This is a survey study of physicians and patients composed of two parts: 1) a physician survey on opioid prescribing practices following gynecologic procedures, and 2) a patient survey on opioid consumption following hysterectomy. DESIGN CLASSIFICATION: III SETTING: An urban academic tertiary care hospital. SUBJECTS: 96 gynecologists in the Boston-area...
November 14, 2017: Journal of Minimally Invasive Gynecology
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