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https://www.readbyqxmd.com/read/28108415/how-does-mindfulness-modulate-self-regulation-in-pre-adolescent-children-an-integrative-neurocognitive-review
#1
REVIEW
Rebekah Jane Kaunhoven, Dusana Dorjee
Pre-adolescence is a key developmental period in which complex intrinsic volitional methods of self-regulation are acquired as a result of rapid maturation within the brain networks underlying the self-regulatory processes of attention control and emotion regulation. Fostering adaptive self-regulation skills during this stage of development has strong implications for physical health, emotional and socio-economic outcomes during adulthood. There is a growing interest in mindfulness-based programmes for pre-adolescents with initial findings suggesting self-regulation improvements, however, neurodevelopmental studies on mindfulness with pre-adolescents are scarce...
January 17, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28089437/systems-innovation-model-an-integrated-interdisciplinary-team-approach-pre-and-post-bariatric-surgery-at-a-veterans-affairs-va-medical-center
#2
Dan Eisenberg, Jessica A Lohnberg, Eric P Kubat, Cheryl C Bates, Lauren M Greenberg, Susan M Frayne
BACKGROUND: Provision of bariatric surgery in the Veterans Health Administration must account for obese veterans' co-morbidity burden and the geographically dispersed location of patients relative to Veterans Affairs (VA) bariatric centers. OBJECTIVES: To evaluate a collaborative, integrated, interdisciplinary bariatric team of surgeons, bariatricians, psychologists, dieticians, and physical therapists working in a hub-and-spokes care model, for pre- and post-bariatric surgery assessment and management...
November 15, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28089397/challenges-for-critical-raw-material-recovery-from-weee-the-case-study-of-gallium
#3
Maximilian Ueberschaar, Sarah Julie Otto, Vera Susanne Rotter
Gallium and gallium compounds are more frequently used in future oriented technologies such as photovoltaics, light diodes and semiconductor technology. In the long term the supply risk is estimated to be critical. Germany is one of the major primary gallium producer, recycler of gallium from new scrap and GaAs wafer producer. Therefore, new concepts for a resource saving handling of gallium and appropriate recycling strategies have to be designed. This study focus on options for a possible recycling of gallium from waste electric and electronic equipment...
January 12, 2017: Waste Management
https://www.readbyqxmd.com/read/28088864/an-integrated-high-throughput-multi-omics-platform-enables-data-driven-construction-of-cellular-responses-and-reveals-global-drug-mechanisms-of-action
#4
Jeremy L Norris, Melissa A Farrow, Danielle B Gutierrez, Lauren D Palmer, Nicole Muszynski, Stacy D Sherrod, James C Pino, Jamie L Allen, Jeffrey M Spraggins, Alex L R Lubbock, Ashley T Jordan, William Burns, James C Poland, Carrie E Romer, M Lisa Manier, Yuan-Wei Nei, Boone M Prentice, Kristie L Rose, Salisha Hill, Raf Van de Plas, Tina Tsui, Nathaniel M Braman, M Ray Keller, Stacey A Rutherford, Nichole A Lobdell, Carlos F Lopez, D Borden Lacy, John A McLean, John Peter Wikswo, Eric P Skaar, Richard M Caprioli
An understanding of how cells respond to perturbation is essential for biological applications; however, most approaches for profiling cellular response are limited in scope to pre-established targets. Global analysis of molecular mechanism will advance our understanding of the complex networks constituting cellular perturbation and lead to advancements in areas, such as infectious disease pathogenesis, developmental biology, pathophysiology, pharmacology, and toxicology. We have developed a high-throughput multi-omics platform for comprehensive, de novo characterization of cellular mechanisms of action...
January 14, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28077616/different-modes-of-enhancer-specific-regulation-by-runt-and-even-skipped-during-drosophila-segmentation
#5
Saiyu Hang, J Peter Gergen
The initial metameric expression of the Drosophila sloppy paired 1 (slp1) gene is controlled by two distinct cis-regulatory DNA elements that interact in a non-additive manner to integrate inputs from transcription factors encoded by the pair-rule segmentation genes. We performed Chromatin Immuno-Precipitation (ChIP) on reporter genes containing these elements in different embryonic genotypes to investigate the mechanism of their regulation. The Distal Early Stripe Element (DESE) mediates both activation and repression by Runt...
January 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28071605/carbon-nanotube-on-eraser-based-eco-friendly-fabrication-of-skin-like-large-area-matrix-of-flexible-strain-and-pressure-sensor
#6
Parikshit Sahatiya, Sushmee Badhulika
This paper reports a new type of electronic, recoverable skin-like pressure and strain sensor on flexible, bio-degradable pencil eraser substrate and has been fabricated by a solvent-free, low-cost and energy efficient process. Multi-walled carbon nanotube (MWCNTs) film as strain sensing element was patterned on pencil eraser by rolling pin and pre-compaction mechanical press which induces high interfacial bonding between the MWCNTs and eraser substrate which enables the sensor to achieve recoverability under ambient conditions...
January 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28061398/energy-performance-of-an-integrated-bio-and-thermal-hybrid-system-for-lignocellulosic-biomass-waste-treatment
#7
Xiang Kan, Zhiyi Yao, Jingxin Zhang, Yen Wah Tong, Wenming Yang, Yanjun Dai, Chi-Hwa Wang
Lignocellulosic biomass waste, a heterogeneous complex of biodegradables and non-biodegradables, accounts for large proportion of municipal solid waste. Due to limitation of single-stage treatment, a two-stage hybrid AD-gasification system was proposed in this work, in which AD acted as pre-treatment to convert biodegradables into biogas followed by gasification converting solid residue into syngas. Energy performance of single and two-stage systems treating 3 typical lignocellulosic wastes was studied using both experimental and numerical methods...
December 28, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/28054910/examining-effects-of-physical-exertion-on-the-dynamic-visual-acuity-test-in-collegiate-athletes
#8
Jessie N Patterson, Anna M Murphy, Julie A Honaker
BACKGROUND: Acute symptoms of dizziness and/or imbalance commonly experienced in athletes postconcussion are speculated to arise from dysfunction at multiple levels (i.e., inner ear or central vestibular system) to appropriately integrate afferent sensory information. Disruption along any pathway of the balance system can result in symptoms of dizziness, decreased postural control function (vestibulospinal reflex), and reduced vestibulo-ocular reflex function. This may also lead to decreased gaze stability with movements of the head and may account for symptoms of blurred vision or diplopia reported in almost half of athletes sustaining a concussion...
January 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28050224/perspectives-from-geriatric-in-patients-with-heart-failure-and-their-caregivers-on-gaps-in-care-quality
#9
Nahid Azad, G Lemay, J Li, M Benzaquen, L Khoury
BACKGROUND: Evidence indicates that care experiences for complex HF patients could be improved by simple organizational and process changes, rather than complex clinical mechanisms. This survey identifies care gaps and recommends simple changes. METHODS: The study utilized both quantitative and qualitative methods at The Ottawa Hospital, Geriatric Medical Unit during a three-month period. RESULTS: Nineteen patients (average age 85, 12 female) surveyed...
December 2016: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/28032925/-on-the-dot-timing-self-assembled-growth-to-the-quantum-scale
#10
Varsha Khare, Sanjiv Sonkaria, Sunghoon Ahn, Caroline S Lee
Understanding the complex world of material growth and tunability has mystified the minds of material scientists and has been met with increasing efforts to close the gap between controllability and applicability. The reality of this journey is frustratingly tortuous but is being eased through better conceptual appreciation of metal crystalline frameworks that originate from shape and size dependent solvent responsive growth patterns. The quantum confinement of TiO2 in the range of 0.8-2 nm has been synthetically challenging to achieve but lessons from biomineralization processes have enabled alternative routes to be explored via self-induced pre-nucleation events...
December 29, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28029782/a-tph2-gfp-reporter-stem-cell-line-to-model-in-vitro-and-in-vivo-serotonergic-neuron-development-and-function
#11
Giulia Pacini, Attilio Marino, Sara Migliarini, Elisa Brilli, Barbara Pelosi, Giacomo Maddaloni, Marta Pratelli, Mario Pellegrino, Aldo Ferrari, Massimo Pasqualetti
Modeling biological systems in vitro has contributed to clarification of complex mechanisms in simplified and controlled experimental conditions. Mouse embryonic stem (mES) cells can be successfully differentiated toward specific neuronal cell fates, thus representing an attractive tool to dissect, in vitro, mechanisms that underlie complex neuronal features. In this study, we generated and characterized a reporter mES cell line, called Tph2(GFP), in which the vital reporter GFP replaces the tryptophan hydroxylase 2 (Tph2) gene...
January 19, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28028238/major-transitions-in-dinoflagellate-evolution-unveiled-by-phylotranscriptomics
#12
Jan Janouškovec, Gregory S Gavelis, Fabien Burki, Donna Dinh, Tsvetan R Bachvaroff, Sebastian G Gornik, Kelley J Bright, Behzad Imanian, Suzanne L Strom, Charles F Delwiche, Ross F Waller, Robert A Fensome, Brian S Leander, Forest L Rohwer, Juan F Saldarriaga
Dinoflagellates are key species in marine environments, but they remain poorly understood in part because of their large, complex genomes, unique molecular biology, and unresolved in-group relationships. We created a taxonomically representative dataset of dinoflagellate transcriptomes and used this to infer a strongly supported phylogeny to map major morphological and molecular transitions in dinoflagellate evolution. Our results show an early-branching position of Noctiluca, monophyly of thecate (plate-bearing) dinoflagellates, and paraphyly of athecate ones...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28017698/metabonomics-of-ageing-towards-understanding-metabolism-of-a-long-and-healthy-life
#13
REVIEW
Francois-Pierre J Martin, Ivan Montoliu, Martin Kussmann
Systems biology approaches have been increasingly employed in clinical studies to enhance our understanding of the role of genetics, environmental factors and their interactions on nutritional, health and disease status. Amongst the new omics technologies, metabonomics has emerged as a robust platform to capture metabolic and nutritional requirements by enabling, in a minimally invasive fashion, the monitoring of a wide range of biochemical compounds. Their variations reflect comprehensively the various molecular regulatory processes, which are tightly controlled and under the influence of genetics, diet, gut microbiota and other environmental factors...
December 23, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28012960/heme-oxygenase-ho-1-induction-prevents-endoplasmic-reticulum-stress-mediated-endothelial-cell-death-and-impaired-angiogenic-capacity
#14
Hatem Maamoun, Matshediso Zachariah, John H McVey, Fiona R Green, Abdelali Agouni
Most of diabetic cardiovascular complications are attributed to endothelial dysfunction and impaired angiogenesis. Endoplasmic Reticulum (ER) and oxidative stresses were shown to play a pivotal role in the development of endothelial dysfunction in diabetes. Hemeoxygenase-1 (HO-1) was shown to protect against oxidative stress in diabetes; however, its role in alleviating ER stress-induced endothelial dysfunction remains not fully elucidated. We aim here to test the protective role of HO-1 against high glucose-mediated ER stress and endothelial dysfunction and understand the underlying mechanisms with special emphasis on oxidative stress, inflammation and cell death...
December 21, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27999735/identification-of-immunotherapeutic-targets-by-genomic-profiling-of-rectal-net-metastases
#15
Zeynep Koşaloğlu, Inka Zörnig, Niels Halama, Iris Kaiser, Ivo Buchhalter, Niels Grabe, Roland Eils, Matthias Schlesner, Andrea Califano, Dirk Jäger
Neuroendocrine tumors (NETs) of the gastrointestinal tract are a rare and heterogeneous group of neoplasms with unique tumor biology and clinical management issues. While surgery is the only curative treatment option in patients with early stage NETs, the optimal management strategy for patients with advanced metastatic NETs is unknown. Based on the tremendous success of immunotherapeutic approaches, we sought to investigate such approaches in a case of metastatic rectal NET. Here, we apply an integrative approach using various computational and experimental methods to explore several aspects of the tumor-host immune interactions for immunotherapeutic options...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27994543/repetitive-tms-on-left-cerebellum-affects-impulsivity-in-borderline-personality-disorder-a-pilot-study
#16
Giulia Zelda De Vidovich, Riccardo Muffatti, Jessica Monaco, Nicoletta Caramia, Davide Broglia, Edgardo Caverzasi, Francesco Barale, Egidio D'Angelo
The borderline personality disorder (BPD) is characterized by a severe pattern of instability in emotional regulation, interpersonal relationships, identity and impulse control. These functions are related to the prefrontal cortex (PFC), and since PFC shows a rich anatomical connectivity with the cerebellum, the functionality of the cerebellar-PFC axis may impact on BPD. In this study, we investigated the potential involvement of cerebello-thalamo-cortical connections in impulsive reactions through a pre/post stimulation design...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27990140/insight-into-the-ervk-integrase-propensity-for-dna-damage
#17
Samantha Bray, Matthew Turnbull, Sherry Hebert, Renée N Douville
Retroviruses create permanently integrated proviruses that exist in the host genome. Retroviral genomes encode for functionally conserved gag, pro, pol, and env regions, as well as integrase (IN), which is required for retroviral integration. IN mediates viral genome insertion through 3' end processing of the viral DNA and the strand transfer reaction. This process requires the formation of a pre-integration complex, comprised of IN, viral DNA, and cellular proteins. Viral insertion causes DNA damage, leading to the requirement of host DNA repair mechanisms...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27982734/increased-complexity-of-circrna-expression-during-species-evolution
#18
Rui Dong, Xu-Kai Ma, Ling-Ling Chen, Li Yang
Circular RNAs (circRNAs) are broadly identified from precursor mRNA (pre-mRNA) back-splicing across various species. Recent studies have suggested a cell-/tissue- specific manner of circRNA expression. However, the distinct expression pattern of circRNAs among species and its underlying mechanism still remain to be explored. Here, we systematically compared circRNA expression from human and mouse, and found that only a small portion of human circRNAs could be determined in parallel mouse samples. The conserved circRNA expression between human and mouse is correlated with the existence of orientation-opposite complementary sequences in introns that flank back-spliced exons in both species, but not the circRNA sequences themselves...
December 16, 2016: RNA Biology
https://www.readbyqxmd.com/read/27959825/integration-of-pathway-knowledge-and-dynamic-bayesian-networks-for-the-prediction-of-oral-cancer-recurrence
#19
Konstantina Kourou, Costas Papaloukas, Dimitrios I Fotiadis
Oral Squamous Cell Carcinoma (OSCC) has been characterized as a complex disease which involves dynamic genomic changes at the molecular level. These changes indicate the worth to explore the interactions of the molecules and especially of differentially expressed genes that contribute to cancer progression. Moreover, based on this knowledge the identification of differentially expressed genes and related molecular pathways is of great importance. In the present study we exploit differentially expressed genes in order to further perform pathway enrichment analysis...
December 7, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27934859/trbp-ensures-efficient-dicer-processing-of-precursor-microrna-in-rna-crowded-environments
#20
Mohamed Fareh, Kyu-Hyeon Yeom, Anna C Haagsma, Sweeny Chauhan, Inha Heo, Chirlmin Joo
The RNA-binding protein TRBP is a central component of the Dicer complex. Despite a decade of biochemical and structural studies, the essential functionality of TRBP in microRNA (miRNA) biogenesis remains unknown. Here we show that TRBP is an integral cofactor for time-efficient Dicer processing in RNA-crowded environments. We competed for Dicer processing of pre-miRNA with a large amount of cellular RNA species and found that Dicer-TRBP, but not Dicer alone, remains resilient. To apprehend the mechanism of this substrate selectivity, we use single-molecule fluorescence...
December 9, 2016: Nature Communications
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