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Danica M Sutherland, Pavithra Aravamudhan, Terence S Dermody
Viruses are constantly engaged in a molecular arms race with the host, where efficient and tactical use of cellular receptors benefits critical steps in infection. Receptor use dictates initiation, establishment, and spread of viral infection to new tissues and hosts. Mammalian orthoreoviruses (reoviruses) are pervasive pathogens that use multiple receptors to overcome protective host barriers to disseminate from sites of initial infection and cause disease in young mammals. In particular, reovirus invades the central nervous system (CNS) with serotype-dependent tropism and disease...
2018: Advances in Virus Research
Xin Li, James A Imlay
Escherichia coli is a model organism that has been exploited to reveal key details of hydrogen peroxide stress: the biomolecules that H2 O2 most rapidly damages and the defensive tactics that organisms use to fend it off. Much less clear is the amount of exogenous H2 O2 that is sufficient to injure the bacterium and/or to trigger its stress response. To fill this gap, we need to study the behavior of cells when they are exposed to defined amounts of H2 O2 on an hours-long time scale. Such experiments are difficult because bacteria rapidly consume H2 O2 that is added to test cultures...
March 14, 2018: Free Radical Biology & Medicine
Masayuki Iwata, Shigeko Saiki-Craighill, Ryouhei Nishina, Ardith Z Doorenbos
OBJECTIVE: The goal was to explore how nurses interact with children in the paediatric intensive care unit during potentially painful procedures. RESEARCH METHODOLOGY/DESIGN: This was a qualitative research study that used grounded theory approach. Data were collected through participant observation and interviews. Nurse-child interactions were observed and recorded during potentially painful procedures performed by nurses. Following observation of a procedure, nurses were interviewed about their intentions, feelings and emotions during the procedure...
March 14, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
Diogo Coutinho, Bruno Gonçalves, Del P Wong, Bruno Travassos, Aaron J Coutts, Jaime Sampaio
This study examined the effects of induced mental and muscular fatigue on soccer players' physical activity profile and collective behavior during small-sided games (SSG). Ten youth soccer players performed a 5vs5 SSG under three conditions: a) control, playing without any previous activity; b) muscular fatigue, playing after performing a repeated change-of-direction task; c) mental fatigue, playing after completing a 30 min Stroop color-word task. Players' positional data was used to compute time-motion and tactical-related variables...
March 14, 2018: Human Movement Science
Adnan Mujezinović, Lejla Čalkić, Nino Hasanica, Salih Tandir
Aim To establish the presence of two risk factors, smoking and alcohol use, for non-communicable diseases among students at the University of Zenica. Methods The research was conducted at eight schools of the University of Zenica in the academic year 2016/2017 during the period from 1 December 2016 to 15 February 2017. The study involved 600 students 19-29 years of age (all years of study). The research was carried out with a standardized and validated questionnaire, the STEPS non-communicable Disease Risk Factors survey, developed by the World Health Organization...
February 1, 2018: Medicinski Glasnik
J Michael Dickson, Xu Wang, Alexander E St John, Esther B Lim, Susan A Stern, Nathan J White
Introduction: Traumatic brain injury (TBI) and hemorrhagic shock (HS) are the leading causes of traumatic death worldwide and particularly on the battlefield. They are especially challenging when present simultaneously (polytrauma), and clear blood pressure end points during fluid resuscitation are not well described for this situation. The goal of this study is to evaluate for any benefit of increasing blood pressure using a vasopressor on brain blood flow during initial fluid resuscitation in a swine polytrauma model...
March 14, 2018: Military Medicine
Henry T Peng, Catherine Tenn, Oshin Vartanian, Shawn G Rhind, Jerzy Jarmasz, Homer Tien, Andrew Beckett
Introduction: Tactical Combat Casualty Care (TCCC) training imposes psychophysiological stress on medics. It is unclear whether these stress levels vary with the training modalities selected. It is also unclear how stress levels could have an impact on medical performance and skill uptake. Materials and Methods: We conducted a pilot study to compare the effects of live tissue (LT) with a high-fidelity patient simulator (SIM) on the level of stress elicited, performance, and skill uptake during battlefield trauma training course in an operating room (OR) and in a simulated battlefield scenario (field)...
March 14, 2018: Military Medicine
Laura Jayne Broome, Cristina Izura, Nuria Lorenzo-Dus
Within the literature individuals who use the internet to facilitate the sexual abuse of a minor are generally classified as being fantasy or contact driven. Classification is based upon the intended location for sexual climax: fantasy driven individuals aim to reach sexual climax online, whereas contact driven individuals target minors to achieve physical sex offline. This review systematically investigates whether there is an empirical basis for the distinction between these two proposed discrete types. Comparison of tactics and behaviour are considered to examine whether the contact vs...
March 12, 2018: Child Abuse & Neglect
Lauren K Lempert, Stanton A Glantz
Introduction: American Indians/Alaska Natives have the highest commercial tobacco use in the United States, resulting in higher tobacco-caused deaths and diseases than the general population. Some American Indians/Alaska Natives use commercial tobacco for ceremonial as well as recreational uses. Because federally-recognized Tribal lands are sovereign, they are not subject to state cigarette taxes and smokefree laws. This study analyzes tobacco industry promotional efforts specifically targeting American Indians/Alaska Natives and exploiting Tribal lands to understand appropriate policy responses in light of American Indians'/Alaska Natives' unique sovereign status and culture...
March 12, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Timothy F Vandervoet, Peter C Ellsworth, Yves Carrière, Steven E Naranjo
Conservation biological control can be an effective tactic for minimizing insect-induced damage to agricultural production. In the Arizona cotton system, a suite of generalist arthropod predators provides critical regulation of Bemisia tabaci Gennadius (MEAM1) (Hemiptera: Aleyrodidae) and other pests. Arthropod predator and B. tabaci populations were manipulated with a range of broad-spectrum and selective insecticide exclusions to vary predator to prey interactions in a 2-yr field study. Predator to prey ratios associated with B...
March 13, 2018: Journal of Economic Entomology
Jason C Tee, Sheree Bekker, Rob Collins, Jannie Klingbiel, Ivan van Rooyen, David van Wyk, Kevin Till, Ben Jones
OBJECTIVES: Due to the complex systems nature of injuries, the responsibility for injury risk management cannot lie solely within a single domain of professional practice. Interdisciplinary collaboration between technical/tactical coaches, strength and conditioning coaches, team doctors, physical therapists and sport scientists is likely to have a meaningful impact on injury risk. This study describes the application and efficacy of a multidisciplinary approach to reducing team injury risk in professional rugby union...
February 14, 2018: Journal of Science and Medicine in Sport
Michael Fuchs, Ruizhi Liu, Ivan Malagoli Lanzoni, Goran Munivrana, Gunter Straub, Sho Tamaki, Kazuto Yoshida, Hui Zhang, Martin Lames
In table tennis, many different approaches to scientific founded match analysis have been developed since the first ones in the 1960s. The aim of this paper is to give a review on some of the most acknowledged methods of match analysis in table tennis. The first chapter presents a historical overview of match analysis from all over the world. The second part reviews different approaches to match analysis in more detail, using the performance analysis classification of theoretical and practical performance analysis...
March 15, 2018: Journal of Sports Sciences
Sindhu Kancherla, Marianne Lorentzen, Victor Snieckus, Kåre Bredeli Jørgensen
A general method for the regioselective synthesis of a series of ortho-substituted chrysenyl N,N-diethyl-O-carbamates by the directed ortho metalation (DoM) strategy is reported. The starting O-carbamates were prepared from corresponding chrysenols, available by oxidative photochemical cyclization or directed remote metalation tactics. Chrysen-1-yl and chrysene-3-yl ring site selectivity of directed ortho metalation (DoM) and anionic ortho Fries rearrangement (AoF) protocols, with s-BuLi/TMEDA, followed by electrophilic quench using a selection of electrophiles, were observed leading to new chrysenyl derivatives...
March 15, 2018: Journal of Organic Chemistry
David Thornby, Jeff Werth, James Hereward, Michelle Keenan, Bhagirath S Chauhan
BACKGROUND: Because herbicide resistance evolves in very large populations over periods of many years, modelling is an important tool for investigating the dynamics of the problem. The Diversity model tracks the simultaneous evolution of resistance to multiple herbicides, using multiple genetic pathways, in several weed species at once. Tracking multiple species and simultaneous resistances is an important development in resistance modelling. We used the Diversity model to test weed management strategies for new cropping cotton varieties with multiple herbicide tolerances ('triple-stacked' varieties), in an Australian context...
March 15, 2018: Pest Management Science
Naser Naser, Ajmol Ali, Paul Macadam
Futsal, the 5-a-side version of soccer (i.e. 1 goalkeeper and 4 outfield players), was introduced in 1930 and continues to grow in popularity around the world. Competitive games comprise of two 20-min periods of high-intensity and intermittent activities requiring substantial physical, tactical, and technical efforts from the players. A greater understanding of the physical and skill requirements will aid the development of futsal and enable practitioners to undertake appropriate training regimes for the demands of the sport...
December 2017: Journal of Exercise Science and Fitness
Ziyad Ben Taleb, Mohammad Ebrahimi Kalan
No abstract text is available yet for this article.
March 14, 2018: Tobacco Control
A G V Salvanes, M J Gibbons
The oceans of the world are slowly losing oxygen, in part because of climate change and in part because of anthropogenic eutrophication. This deoxygenation affects marine organisms in species-specific ways. This paper reviews what is known on how hypoxia tolerant species respond to low dissolved oxygen, using the bearded goby Sufflogobius bibarbatus as a model system. This species is endemic to the Benguela upwelling ecosystem, where, off Namibia, 9000 km2 of the shelf is hypoxic. Here, the species is now considered central to ecosystem functioning and in recent decades it has sustained commercial fisheries...
March 2018: Journal of Fish Biology
Burak M Gönültaş, Bahadir Sahin
A great deal of attention has been devoted to sexual molestation cases, both in theory and in practice. Child molesters are versatile and are not easily identified. Various theories and tactics, the most contemporary of which is environmental criminology, have been developed to find those criminals. Locations of victims, crime scenes, and distances among them as well as other situational variables are used to predict possible future offences in environmental criminology. This study applies the theory to sexual molestation crimes in Istanbul...
April 2018: International Journal of Offender Therapy and Comparative Criminology
Shannon Gwin Mitchell, Laura B Monico, Elizabeth Lertch, Sharon M Kelly, Jan Gryczynski, Jerome H Jaffe, Kevin E O'Grady, Robert P Schwartz
Conflicts with methadone program counseling staff and violations of program rules can contribute to patients leaving treatment prematurely. This qualitative study was conducted as part of a larger trial of patient-centered methadone treatment (PCM). In-depth, semi-structured interviews at baseline and 12-month follow-up were conducted with five counselors and three clinical supervisors from the programs participating in the PCM parent study. Data were analyzed using Atlas.ti. Counselors reported that, in some cases, PCM allowed them to focus on building a therapeutic alliance with patients because they were not addressing program rule issues...
March 13, 2018: Journal of Behavioral Health Services & Research
Maureen Campion, Gail Scully
Appropriate antimicrobial therapy is essential to ensuring positive patient outcomes. Inappropriate or suboptimal utilization of antibiotics can lead to increased length of stay, multidrug-resistant infections, and mortality. Critically ill intensive care patients, particularly those with severe sepsis and septic shock, are at risk of antibiotic failure and secondary infections associated with incorrect antibiotic use. Through the initiation of active empiric antibiotic therapy based upon local susceptibilities, daily evaluation of signs and symptoms of infection and narrowing of antibiotic therapy when feasible, providers can streamline the treatment of common intensive care unit (ICU) infections...
January 1, 2018: Journal of Intensive Care Medicine
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