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Cardiac biomarkers

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https://www.readbyqxmd.com/read/28549860/crude-terpene-glycoside-component-from-radix-paeoniae-rubra-protects-against-isoproterenol-induced-myocardial-ischemic-injury-via-activation-of-the-pi3k-akt-mtor-signaling-pathway
#1
Zhongcheng Ke, Gang Wang, Lei Yang, Huihui Qiu, Hao Wu, Mei Du, Juan Chen, Jie Song, Xiaobin Jia, Liang Feng
ETHNOPHARMACOLOGICAL RELEVANCE: Radix paeoniae rubra, also known as chishao (CS), is a frequently used traditional Chinese medicine that can promote blood circulation to remove blood stasis. It has been widely used for the prevention and treatment of cardiovascular diseases in China. Although terpene glycoside (TG), the major component in CS, has been shown to possess cardioprotective properties, the mechanism underlying CS-TG's preventive effect against myocardial ischemia injury is unknown...
May 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28545400/the-role-of-a-behavioural-medicine-intervention-in-physiotherapy-for-the-effects-of-rehabilitation-outcomes-in-exercise-based-cardiac-rehabilitation-ecra-the-study-protocol-of-a-randomised-controlled-trial
#2
Sabina Borg, Birgitta Öberg, Lennart Nilsson, Anne Söderlund, Maria Bäck
BACKGROUND: To help patients with coronary artery disease (CAD) benefit from the positive health effects attained by exercise-based cardiac rehabilitation (CR), adherence to these programmes according to international guidelines is important. Strategies to increase adherence to exercise-based CR are mainly an unexplored area. The objective of this study is to investigate the effects of a behavioural medicine intervention in physiotherapy, containing goal-setting, self-monitoring and feedback, with the aim of improving rehabilitation outcomes for exercise-based CR, compared with usual care...
May 25, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28545116/n-terminal-pro-b-type-natriuretic-peptide-in-amniotic-fluid-of-fetuses-with-known-or-suspected-cardiac-load
#3
Christina Leufgen, Ulrich Gembruch, Birgit Stoffel-Wagner, Rolf Fimmers, Waltraut M Merz
BACKGROUND: Myocardial dysfunction occurs in a variety of fetal disorders. Findings from adult cardiology, where n-terminal pro-B-type natriuretic peptide (nt-proBNP) is an established biomarker of left ventricular dysfunction have been extended to fetal life. Since fetal blood sampling is technically challenging we investigated amniotic fluid nt-proBNP for its suitability to diagnose fetal myocardial dysfunction. METHODS: Ultrasound, Doppler examination and echocardiography was applied to classify cases and controls...
2017: PloS One
https://www.readbyqxmd.com/read/28542263/inflammatory-biomarkers-as-predictors-of-heart-failure-in-women-without-obstructive-coronary-artery-disease-a-report-from-the-nhlbi-sponsored-women-s-ischemia-syndrome-evaluation-wise
#4
Ahmed AlBadri, Kha Lai, Janet Wei, Sofy Landes, Puja K Mehta, Quanlin Li, Delia Johnson, Steven E Reis, Sheryl F Kelsey, Vera Bittner, George Sopko, Leslee J Shaw, Carl J Pepine, C Noel Bairey Merz
BACKGROUND: Women with signs and symptoms of ischemia, no obstructive coronary artery disease (CAD) and preserved left ventricular ejection fraction (EF) often have diastolic dysfunction and experience elevated rates of major adverse cardiac events (MACE), including heart failure (HF) hospitalization with preserved ejection fraction (HFpEF). We evaluated the predictive value of inflammatory biomarkers for long-term HF hospitalization and all-cause mortality in these women. METHODS: We performed a cross-sectional analysis to investigate the relationships between inflammatory biomarkers [serum interleukin-6 (IL-6), C-reactive protein (hs-CRP) and serum amyloid A (SAA)] and median of 6 years follow-up for all-cause mortality and HF hospitalization among women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF...
2017: PloS One
https://www.readbyqxmd.com/read/28540066/cine-cmr-partial-voxel-segmentation-demonstrates-increased-aortic-stiffness-among-patients-with-marfan-syndrome
#5
Parmanand Singh, Zaid Almarzooq, Noel C F Codell, Yi Wang, Mary J Roman, Richard B Devereux, Jonathan W Weinsaft
BACKGROUND: Standard cine-cardiac magnetic resonance (CMR) imaging is commonly used to evaluate cardiac structure, geometry and function. Prior studies have shown that automated segmentation via partial voxel interpolation (PVI) accurately quantifies phantom-based cardiac chamber volumes and necropsy left ventricular myocardial mass. Despite this, the applicability and usefulness of PVI in the determination of physiologic parameters of the aorta such as aortic stiffness has yet to be investigated...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28539741/potential-roles-of-kleinhovia-hospita-l-leaf-extract-in-reducing-doxorubicin-acute-hepatic-cardiac-and-renal-toxicities-in-rats
#6
Yulia Yusrini Djabir, M Aryadi Arsyad, Sartini Sartini, Subehan Lallo
BACKGROUND: Doxorubicin (DOX) is a potent chemotherapy agent; however, its use may lead to cardiac, hepatic, and renal dysfunction. Kleinhovia hospita L extract contains antioxidant compounds that have been shown to reduce chemical-induced hepatotoxicity. OBJECTIVES: This study aimed to examine the protective effects of Kleinhovia sp. extract to reduce DOX acute toxicities. MATERIALS AND METHODS: Thirty male rats were assigned to the following groups: Group I as controls, Group II was given DOX i...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28536533/heart-rate-fragmentation-a-new-approach-to-the-analysis-of-cardiac-interbeat-interval-dynamics
#7
Madalena D Costa, Roger B Davis, Ary L Goldberger
Background: Short-term heart rate variability (HRV) is most commonly attributed to physiologic vagal tone modulation. However, with aging and cardiovascular disease, the emergence of high short-term HRV, consistent with the breakdown of the neuroautonomic-electrophysiologic control system, may confound traditional HRV analysis. An apparent dynamical signature of such anomalous short-term HRV is frequent changes in heart rate acceleration sign, defined here as heart rate fragmentation. Objective: The aims were to: (1) introduce a set of metrics designed to probe the degree of sinus rhythm fragmentation; (2) test the hypothesis that the degree of fragmentation of heartbeat time series increases with the participants' age in a group of healthy subjects; (3) test the hypothesis that the heartbeat time series from patients with advanced coronary artery disease (CAD) are more fragmented than those from healthy subjects; and (4) compare the performance of the new fragmentation metrics with standard time and frequency domain measures of short-term HRV...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28534047/polysomnographic-heart-rate-variability-indices-and-atrial-ectopy-associated-with-incident-atrial-fibrillation-risk-in-older-community-dwelling-men
#8
Dileep Raman, Farhad Kaffashi, Li-Yung Lui, William H Sauer, Susan Redline, Peter Stone, Peggy M Cawthon, Katie L Stone, Kristine E Ensrud, Sonia Ancoli-Israel, Kenneth Loparo, Reena Mehra
BACKGROUND: Autonomic dysfunction contributes to atrial fibrillation (AF). OBJECTIVE: We hypothesized that polysomnogram (PSG)-based heart rate variability (HRV) autonomic function biomarkers are associated with incident AF and these associations are modified by measures of sleep disordered breathing (SDB). METHODS: 2350 participants of a multi-center prospective study (Outcomes of Sleep Disorders in Older Men Study) without baseline AF underwent sleep studies with incident adjudicated AF follow up (8...
May 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28533931/altered-expression-of-c-kit-and-nanog-in-a-rat-model-of-adriamycin-induced-chronic-heart-failure
#9
Shuo Li, Kang Guo, Junfang Wu, Zhikun Guo, Airong Li
A small number of cardiac stem cells that express the c-Kit and Nanog biomarkers can be differentiated into myocardial cells, which suggests that these stem cells may be able to repair damage and provide an internal reserve for tissue regeneration. It is unknown, however, whether the levels of myocardial stem cells are altered after heart failure (HF), and whether HF affects the myocardial regenerative ability. In this study, to address this question, we developed a rat model of chronic HF induced by Adriamycin, and examined the morphological changes in c-Kit and Nanog-expressing stem cells in heart tissue of normal and HF rats...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28533142/evaluation-of-plasma-sphingosine-1-phosphate-hepcidin-and-cardiovascular-damage-biomarkers-cardiac-troponin-i-and-homocysteine-in-rats-infected-with-brucellosis-and-vaccinated-rev-1-rb-51
#10
Kaveh Azimzadeh, Reza Nasrollahi Nargesabad, Nasim Vousooghi
Brucellosis is known as one of important zoonosis. Studying the histological and biochemical effects of the disease could help to increase our knowledge about it. The aim of the present study was to evaluate changes of plasma parameters after intraperitoneal injection of two species of Brucella (Brucella melitensis and Brucella abortus) and two vaccines (Rev-1, RB-51) in the rat. Forty male rats were divided into five groups (n = 8 in each group). Two groups received suspensions of Brucella abortus and Brucella melitensis and two other groups were injected intraperitoneally with two mentioned vaccines and the last group received only distilled water...
May 19, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28530078/-athlete-s-heart-the-more-the-merrier
#11
REVIEW
Reut Shavit, Michael Glikson, Naama Constantini
Regular moderate exercise training is effective for the prevention and treatment of many common chronic diseases and improves cardiovascular health and life expectancy. However, long-term excessive endurance exercise may induce pathological structural remodeling of the heart. The athlete's heart is characterized by enlargement of cardiac chambers and eccentric hypertrophy with preserved myocardial function as normal physiological adaptations for prolonged and intense endurance physical stress. However, recent studies have demonstrated transient right ventricular dysfunction and elevation of cardiac biomarkers following intense endurance exercise...
September 2016: Harefuah
https://www.readbyqxmd.com/read/28528401/cardiovascular-disease-biomarkers-are-associated-with-declining-renal-function-in-type-2-diabetes
#12
Sara J Jenks, Bryan R Conway, Stela McLachlan, Wei Leng Teoh, Rachel M Williamson, David J Webb, Paul Welsh, Naveed Sattar, Mark W J Strachan, Jackie F Price
AIMS/HYPOTHESIS: We investigated whether biochemical cardiovascular risk factors and/or markers of subclinical cardiovascular disease were associated with the development of reduced renal function in people with type 2 diabetes. METHODS: A cohort of 1066 Scottish men and women aged 60-74 years with type 2 diabetes from the Edinburgh Type 2 Diabetes Study were followed up for a median of 6.7 years. New-onset reduced renal function was defined as two eGFRs <60 ml(-1) min(-1) (1...
May 20, 2017: Diabetologia
https://www.readbyqxmd.com/read/28524005/rivaroxaban-metabolism-pharmacologic-properties-and-drug-interactions
#13
Tomas Kvasnicka, Ivana Malikova, Zuzana Zenahlikova, Karolína Kettnerova, Radka Brzezkova, Tomas Zima, Jan Ulrych, Jan Briza, Ivan Netuka, Jan Kvasnicka
BACKGROUND: Rivaroxaban represents a selective direct inhibitor of activated coagulation factor X (FXa) having peroral bioavailability and prompt onset of action. OBJECTIVE: The absorbtion of rivaroxaban is quick, reaching maximum plasma concentration 2-4 hours following its administration. Peroral bioavailability is high (80-100 %) and pharmacokinetic variability is considered to be moderate (coefficient of variation 30-40 %). This review discusses the properties, drug interactions, pharmacokinetics and clinical indications of rivaroxaban...
May 18, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28523858/clinical-signs-diagnostics-and-successful-treatment-of-a-myocarditis-in-an-adult-chimpanzee-pan-troglodytes
#14
Martine van Zijll Langhout, Marno Wolters, Katalin M Horvath, Harold Thiesbrummel, Paul Smits, Hester van Bolhuis, Victor van der Hulst, Robert Riezebos
A chimpanzee (Pan troglodytes) was presented with lethargic behaviour. Echocardiography and abnormal cardiac and inflammatory biomarkers revealed a myocarditis. The animal fully recovered after prolonged treatment with losartan and carvedilol. This is the first report of the diagnosis and successful treatment of myocarditis in this species.
May 19, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28523165/plasma-levels-of-matrix-metalloproteinase-9-in-patients-undergoing-off-pump-coronary-artery-bypass-grafting
#15
Haiqing Li, Zhize Yuan, Sen Li, Quan Qi, Jun Liu, Mi Zhou, Junfeng Cai, Anqing Chen, Zhe Wang, Xiaofeng Ye, Qiang Zhao
BACKGROUND: Matrix metalloproteinase 9 (MMP9) has recently emerged as a risk predictor in patients with cardiovascular diseases. However, little is known about the significance of increased plasma MMP9 in patients with perioperative myocardial injury. We aimed to investigate the role of MMP9 in the occurrence of myocardial injury during off-pump coronary artery bypass grafting (OPCAB). METHODS: A total of 34 consecutive patients with coronary artery diseases (CAD) were recruited in this prospective, observational study...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28521548/mitochondrial-dna-heteroplasmy-in-cardiac-tissue-from-individuals-with-and-without-coronary-artery-disease
#16
Erik Hefti, Javier Guillermo Blanco
The cellular environment associated with coronary artery disease (CAD) can lead to mitochondrial DNA (mtDNA) damage. Mitochondrial variants in some copies of mtDNA (heteroplasmy) and mtDNA content are potential genetic biomarkers for CAD-associated disease states. Massively parallel sequencing and qRT-PCR techniques were used to measure heteroplasmic variants and mtDNA content in heart samples from donors with (n = 8) and without (n = 7) documented CAD. Both groups showed increased numbers of heteroplasmic mtDNA variants in the control region (CR) (p < ...
May 19, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28520682/progress-in-the-pathogenesis-and-treatment-of-cardiac-manifestations-of-neonatal-lupus
#17
Peter Izmirly, Amit Saxena, Jill P Buyon
PURPOSE OF REVIEW: To provide new insights into pathogenesis, prevention and management of cardiac manifestations of neonatal lupus (cardiac neonatal lupus) and issues pertinent to all anti-SSA/Ro positive individuals of childbearing age. RECENT FINDINGS: Antibody specificity with high risk for cardiac neonatal lupus remains elusive, but high titers of Ro60, Ro52 or Ro52p200 antibodies appear to be required. Varying antibody specificities to the p200 region of Ro52 can induce first-degree block in a rodent model...
May 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28516504/prognostic-potential-of-midregional-pro-adrenomedullin-following-decompensation-for-systolic-heart-failure-comparison-with-cardiac-natriuretic-peptides
#18
Caroline Morbach, Almuth Marx, Mathias Kaspar, Gülmisal Güder, Susanne Brenner, Carolin Feldmann, Stefan Störk, Jörn O Vollert, Georg Ertl, Christiane E Angermann
AIMS: Whereas guidelines recommend the routine use of natriuretic peptides (NPs) in heart failure (HF) care, the clinical relevance and prognostic potential of midregional pro-adrenomedullin (MR-proADM) is less well established. We aimed to compare the prognostic potential of MR-proADM after acute decompensation for systolic HF with that of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and midregional pro-atrial NP (MR-proANP), to investigate the significance of high/rising MR-proADM, and to evaluate the incremental prognostic yield of repeat measurements...
May 17, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28516275/the-role-of-cardiac-biomarkers-in-pregnancy
#19
REVIEW
Emily S Lau, Amy Sarma
Cardiovascular disease (CVD) is the leading cause of pregnancy-associated mortality, with an increasingly complex pregnant population. While our understanding of CVD in pregnancy continues to evolve, there remains a need to develop widely accessible tools to follow pregnant women both with and without preexisting disease with respect to cardiovascular risk, particularly for those presenting with symptoms suggestive of cardiovascular pathology. Thus, research is emerging with respect to the potential role of novel and established cardiac biomarkers in diagnosing and following CVD in pregnancy...
July 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28515849/feature-tracking-cardiac-magnetic-resonance-imaging-a-review-of-a-novel-non-invasive-cardiac-imaging-technique
#20
REVIEW
Zia Ur Rahman, Pooja Sethi, Ghulam Murtaza, Hafeez Ul Hassan Virk, Aitzaz Rai, Masliza Mahmod, Jeffrey Schoondyke, Kais Albalbissi
Cardiovascular disease is a leading cause of morbidity and mortality globally. Early diagnostic markers are gaining popularity for better patient care disease outcomes. There is an increasing interest in noninvasive cardiac imaging biomarkers to diagnose subclinical cardiac disease. Feature tracking cardiac magnetic resonance imaging is a novel post-processing technique that is increasingly being employed to assess global and regional myocardial function. This technique has numerous applications in structural and functional diagnostics...
April 26, 2017: World Journal of Cardiology
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