keyword
https://read.qxmd.com/read/38493402/high-baseline-high-sensitivity-cardiac-troponin-t-concentrations-and-risk-of-index-acute-myocardial-infarction
#1
JOURNAL ARTICLE
Jonathan D Knott, Olatunde Ola, Laura De Michieli, Ashok Akula, Eric H Yang, S Michael Gharacholou, Josh Slusser, Bradley Lewis, Ramila A Mehta, Rajiv Gulati, Yader Sandoval, Allan S Jaffe
OBJECTIVE: To evaluate the diagnostic performance of the previously recommended baseline high-sensitivity cardiac troponin T (hs-cTnT) thresholds of 52 and 100 ng/L in identifying patients at high risk of acute myocardial infarction (AMI). PATIENTS AND METHODS: This study compared the positive predictive value (PPV) for index AMI of these high-risk hs-cTnT thresholds in adult patients in the emergency department undergoing hs-cTnT measurement. RESULTS: The adjudicated MAyo Southwest Wisconsin 5th Gen Troponin T ImplementatiON cohort included 2053 patients, with 157 (7...
March 15, 2024: Mayo Clinic Proceedings
https://read.qxmd.com/read/38492623/a-review-regarding-the-article-supervised-exercise-training-in-heart-failure-with-preserved-ejection-fraction-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Ping Zhang, Yunfei Ling
Heart failure is a clinical syndrome with different etiologies and phenotypes. For all forms, supervised exercise training and individual physical activity are class IA recommendations in current guidelines. Over the past two decades it has become recognized that physical deconditioning may play a key role in the progression of symptoms and poor outcomes. A number of prior studies have assessed the ability of exercise training to improve functional capacity in patients with HF. Most of these previous studies showed positive effects of exercise training on exercise capacity, quality of life, and biomarkers and observed relatively few complications during training...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38492617/a-multidisciplinary-approach-of-a-patient-with-pheochromocytoma-presenting-as-recurrent-acute-fulminant-myocarditis-a-rare-case-report-and-comprehensive-review-of-literature
#3
REVIEW
Januar Wibawa Martha, Hawani Sasmaya Prameswari, Fatihatul Firdaus Munita, Nuraini Yasmin Kusumawardhani, Melawati Hasan, Astri Astuti, Nanny Natalia Mulyani, Hasrayati Agustina, Minsy Titi Sari
Fulminant myocarditis (FM) is a rare illness characterized by abrupt and severe widespread cardiac inflammation, which frequently results in mortality due to cardiogenic shock, ventricular arrhythmias, or multiorgan system failure. Pheochromocytoma is an uncommon and difficult-to-diagnose cause of FM, and it is associated with a significant risk of recurrent acute myocarditis. There is, however, little information on reoccurring acute FM. Herein, we report a rare case of recurrent acute FM due to pheochromocytoma...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38491548/fulminant-myocarditis-during-postoperative-adjuvant-chemotherapy-for-lung-cancer-with-atezolizumab-a-case-report
#4
JOURNAL ARTICLE
Takuya Tokunaga, Masaya Aoki, Koki Maruyama, Yuto Nonaka, Kota Kariatsumari, Koichi Sakasegawa, Kazuhiro Ueda
BACKGROUND: Postoperative adjuvant systemic therapy with atezolizumab for lung cancer has been reported to be effective. Although myocarditis is a rare immune adverse event associated with atezolizumab, it can have a serious course and should be treated with caution. We herein report a case of fulminant myocarditis during adjuvant systemic therapy with atezolizumab. CASE PRESENTATION: The patient was a 49-year-old Asian woman. She was diagnosed with pT2aN1M0 stage IIB (Programmed Death Ligand 1(PD-L1), 50%) after surgery for right upper lobe lung adenocarcinoma...
March 16, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38491513/identification-of-mir-20b-5p-as-an-inhibitory-regulator-in-cardiac-differentiation-via-tet2-and-dna-hydroxymethylation
#5
JOURNAL ARTICLE
Ke-Xin Li, Jia-Ru Li, Sheng-Jia Zuo, Xudong Li, Xian-Tong Chen, Pei-Yi Xiao, Hui-Tao Li, Ling Sun, Tao Qian, Hao-Min Zhang, Dongxing Zhu, Xi-Yong Yu, Guojun Chen, Xue-Yan Jiang
BACKGROUND: Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diagnosis and intervention. MicroRNAs, as epigenetic regulators of cardiac development, provide potential biomarkers for the diagnosis and treatment of CHD. However, the mechanisms underlying miRNAs-mediated regulation of cardiac development and CHD malformation remain to be further elucidated. This study aimed to explore the function of microRNA-20b-5p (miR-20b-5p) in cardiac development and CHD pathogenesis...
March 15, 2024: Clinical Epigenetics
https://read.qxmd.com/read/38490844/left-atrial-cardiomyopathy-pathophysiological-insights-assessment-methods-and-clinical-implications
#6
REVIEW
Sandro Ninni, Vincent Algalarrondo, Fabien Brette, Gilles Lemesle, Jérémy Fauconnier
Atrial cardiomyopathy is defined as any complex of structural, architectural, contractile or electrophysiological changes affecting atria, with the potential to produce clinically relevant manifestations. Most of our knowledge about the mechanistic aspects of atrial cardiomyopathy is derived from studies investigating animal models of atrial fibrillation and atrial tissue samples obtained from individuals who have a history of atrial fibrillation. Several noninvasive tools have been reported to characterize atrial cardiomyopathy in patients, which may be relevant for predicting the risk of incident atrial fibrillation and its related outcomes, such as stroke...
March 1, 2024: Archives of Cardiovascular Diseases
https://read.qxmd.com/read/38490307/high-sensitivity-cardiac-troponins-in-patients-with-chest-pain-and-treatment-with-oral-antineoplastic-agents-associated-with-cardiovascular-toxicity
#7
JOURNAL ARTICLE
Andreas Roos, Gustaf Edgren
BACKGROUND: Knowledge on the clinical implications of high-sensitivity cardiac troponin (hs-cTn) measurements in patients treated with oral antineoplastic agents associated with cardiovascular side effects is limited. This study investigated the diagnostic performance of hs-cTnT for myocardial infarction. METHODS: Among all visits to 7 different emergency departments (EDs) from December 9, 2010 to August 31, 2017, we included visits by patients presenting with chest pain who had ≥1 hs-cTnT measured...
March 13, 2024: American Journal of Medicine
https://read.qxmd.com/read/38488292/sodium-glucose-cotransporter-2-inhibitors-for-transthyretin-amyloid-cardiomyopathy-analyses-of-short-term-efficacy-and-safety
#8
JOURNAL ARTICLE
Frederick M Lang, Sergio Teruya, Ariel Weinsaft, Margaret Cuomo, Alfonsina Mirabal Santos, Ani Nalbandian, Dimitrios Bampatsias, Mathew S Maurer
AIMS: Despite their potential, sodium-glucose cotransporter 2 inhibitors (SGLT2i) have not been well-studied in transthyretin amyloid cardiomyopathy (ATTR-CM) as randomized trials have excluded patients with this morbid disease. We performed a retrospective study assessing the short-term efficacy and safety of SGLT2i in ATTR-CM. METHODS AND RESULTS: We screened consecutive patients seen at a tertiary care centre and identified 87 ATTR-CM patients treated with SGLT2i and 95 untreated control patients...
March 15, 2024: European Journal of Heart Failure
https://read.qxmd.com/read/38487045/pathophysiology-of-myocardial-infarction-with-nonobstructive-coronary-artery-disease-a-contemporary-systematic-review
#9
REVIEW
Laurie-Anne Boivin-Proulx, Kevin Haddad, Marco Lombardi, Aun Yeong Chong, Javier Escaned, Swati Mukherjee, Jessica Forcillo, Brian J Potter, Thais Coutinho, Christine Pacheco
BACKGROUND: Myocardial infarction with nonobstructive coronary artery disease (MINOCA) is defined as acute myocardial infarction (AMI) with angiographically nonobstructive coronary artery disease. MINOCA represents 6% of all AMI cases and is associated with increased mortality and morbidity. However, the wide array of pathophysiological factors and causes associated with MINOCA presents a diagnostic conundrum. Therefore, we conducted a contemporary systematic review of the pathophysiology of MINOCA...
February 2024: CJC open
https://read.qxmd.com/read/38486199/mct4-dependent-lactate-transport-a-novel-mechanism-for-cardiac-energy-metabolism-injury-and-inflammation-in-type-2-diabetes-mellitus
#10
JOURNAL ARTICLE
Xiu Mei Ma, Kang Geng, Peng Wang, Zongzhe Jiang, Betty Yuen-Kwan Law, Yong Xu
Diabetic cardiomyopathy (DCM) is a major contributor to mortality in diabetic patients, characterized by a multifaceted pathogenesis and limited therapeutic options. While lactate, a byproduct of glycolysis, is known to be significantly elevated in type 2 diabetes, its specific role in DCM remains uncertain. This study reveals an abnormal upregulation of monocarboxylate transporter 4 (MCT4) on the plasma membrane of cardiomyocytes in type 2 diabetes, leading to excessive lactate efflux from these cells. The disruption in lactate transport homeostasis perturbs the intracellular lactate-pyruvate balance in cardiomyocytes, resulting in oxidative stress and inflammatory responses that exacerbate myocardial damage...
March 14, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38485036/analysis-and-validation-of-hub-genes-in-neutrophil-extracellular-traps-for-the-long-term-prognosis-of-myocardial-infarction
#11
JOURNAL ARTICLE
Xuan Li, Wenyu Wu, Huan He, Lin Guan, Guancheng Chen, Zhijun Lin, Huan Li, Jialin Jiang, Xin Dong, Zhuoji Guan, Pinliang Chen, Zigang Pan, Weiwei Huang, Runjia Yu, Wenxin Song, Lu Lu, Zhongqi Yang, Zixin Chen, Lingjun Wang, Shaoxiang Xian, Jie Chen
INTRODUCTION: The study focuses on the long-term prognosis of myocardial infarction (MI) influenced by neutrophil extracellular traps (NETs). It also aims to analyze and validate relative hub genes in this process, in order to further explore new therapeutic targets that can improve the prognosis of MI. MATERIALS AND METHODS: We established a MI model in mice by ligating the left anterior descending branch (LAD) and conducted an 8-week continuous observation to study the dynamic changes in the structure and function of the heart in these mice...
March 12, 2024: Gene
https://read.qxmd.com/read/38483418/clinical-predictors-of-device-detected-atrial-fibrillation-during-2-5-years-after%C3%A2-cardiac-surgery-prospective-race-v-cohort
#12
JOURNAL ARTICLE
Martijn D Gilbers, Michal J Kawczynski, Elham Bidar, Bart Maesen, Aaron Isaacs, Joris Winters, Dominik Linz, Michiel Rienstra, Isabelle van Gelder, Jos G Maessen, Ulrich Schotten
BACKGROUND: Postoperative atrial fibrillation (POAF) is a frequent complication after cardiac surgery that is associated with late atrial fibrillation (AF) recurrences (late-POAF) and increased morbidity and long-term mortality. OBJECTIVES: This study sought to determine device-detected POAF incidence and to identify clinical variables associated with POAF, both in patients with and without preoperative AF history. METHODS: A total of 133 consecutive patients undergoing cardiac surgery were prospectively enrolled and continuously monitored with an implantable loop recorder for 2...
February 28, 2024: JACC. Clinical Electrophysiology
https://read.qxmd.com/read/38483417/clinical-characterization-of-arrhythmia-induced-cardiomyopathy-in-patients-with-tachyarrhythmia-and-idiopathic-heart%C3%A2-failure
#13
JOURNAL ARTICLE
Christian Schach, Thomas Körtl, Florian Zeman, Bianca Luttenberger, Franziska Mühleck, Paul Baum, Daniel Lavall, Nicola H Vosshage, Markus Resch, Sarah Ripfel, Christine Meindl, Ekrem Ücer, Okka W Hamer, Andrea Baessler, Michael Arzt, Michael Koller, Christian Sohns, Lars S Maier, Rolf Wachter, Samuel Sossalla
BACKGROUND: Arrhythmia-induced cardiomyopathy (AIC) is a known entity, but prospective evidence for its characterization is limited. OBJECTIVES: This study aimed to: 1) determine the relative frequency of the pure form of AIC in the clinically relevant cohort of patients with newly diagnosed, otherwise unexplained left ventricular systolic dysfunction (LVSD) and tachyarrhythmia; 2) assess the time to recovery from LVSD; and 3) identify parameters for an early diagnosis of AIC...
February 28, 2024: JACC. Clinical Electrophysiology
https://read.qxmd.com/read/38483076/influence-of-a-7-day-transalpine-trail-run-on-cardiac-biomarkers-and-myocardial-function
#14
JOURNAL ARTICLE
Katrin Esefeld, Marisa Geisberger, Sophia Marie-Theres Dinges, Johanna Hambrecht, Felix Stegmüller, Michael Rasper, Jonathan Nadjiri, Franz Roeschenthaler, Stefan Holdenrieder, Jürgen Scharhag, Martin Halle
Intense physical exercise is known to increase cardiac biomarkers; however, it is unclear, whether this phenomenon is physiological, or if it indicates myocardial tissue injury. The aim of our study was to investigate the effects of seven consecutive days of excessive endurance exercise on continuous assessment of cardiac biomarkers, function, and tissue injury. During a 7-day trail-running competition (Transalpine Run, distance 267.4 km, altitude ascent/descent 15556/14450 m), daily blood samples were obtained for cardiac biomarkers (hs-TnT, NT-proBNP, and suppression of tumorigenicity-2 protein (ST2)) at baseline, after each stage and 24-48 h post-race...
March 2024: Scandinavian Journal of Medicine & Science in Sports
https://read.qxmd.com/read/38481645/a-case-of-cardiac-sarcoidosis-mimicking-acute-phase-of-takotsubo-cardiomyopathy-evaluated-by-multimodality-cardiac-imaging
#15
Yasuyuki Takada, Satoshi Hida, Masatsune Fujii, Yoshinao Yazaki, Kazuhiro Satomi
UNLABELLED: The patient was a 68-year-old woman who experienced loss of consciousness owing to a seizure while walking and bruised her face. Twelve‑lead electrocardiography displayed a complete atrioventricular block. Transthoracic echocardiography displayed hypokinesis from the middle to apex of the myocardium. Emergency coronary angiography displayed no clear stenosis of the coronary arteries, and left ventriculography displayed takotsubo-like abnormal left ventricular wall motion...
March 2024: Journal of Cardiology Cases
https://read.qxmd.com/read/38481150/evaluation-of-clinical-characteristics-and-risk-factors-associated-with-chlamydia-psittaci-infection-based-on-metagenomic-next-generation-sequencing
#16
JOURNAL ARTICLE
Lei Yuan, Qiang Chen, Xin Yu Zhu, Lan Min Lai, Rui Zhao, Yang Liu
INTRODUCTION: Psittacosis is a zoonosis caused by Chlamydia psittaci, the clinical manifestations of Psittacosis range from mild illness to fulminant severe pneumonia with multiple organ failure. This study aimed to evaluate the clinical characteristics of Chlamydia psittaci infection diagnosed based on metagenomic next-generation sequencing(mNGS), as well as the risk factors affecting the progress of Chlamydia psittaci infection, in order to improve the effect of therapeutics. METHODS: We retrospectively analyzed the clinical data of patients infected with chlamydia psittaci in the First Affiliated Hospital of Nanchang University from January 2021 to December 2021...
March 13, 2024: BMC Microbiology
https://read.qxmd.com/read/38478369/invited-commentary-omics-approaches-to-mechanistic-biomarker-and-therapeutic-development-for-right-ventricular-failure-in-congenital-right-sided-obstructive-lesions-a-brave-new-world
#17
JOURNAL ARTICLE
Jesse A Davidson, Lindsay M Thomson, Benjamin S Frank
No abstract text is available yet for this article.
March 2024: World Journal for Pediatric & Congenital Heart Surgery
https://read.qxmd.com/read/38476975/a-cost-effectiveness-evaluation-of-a-high-sensitivity-troponin-i-guided-voluntary-cardiovascular-risk-assessment-program-for-asymptomatic-women-in-croatia
#18
JOURNAL ARTICLE
Goran Krstačić, Paul Jülicher, Antonija Krstačić, Christos Varounis
BACKGROUND: To estimate the effectiveness and cost-effectiveness of a high-sensitivity troponin I (hsTnI) guided cardiovascular risk assessment program in women in Croatia. METHODS: An observational study of a voluntary program for cardiovascular disease (CVD) risk assessment in women aged above 45 years with no specific symptoms, no confirmed or known coronary artery disease was conducted (WHP). Participants were stratified into three categories according to their hsTnI level...
March 2024: Int J Cardiol Cardiovasc Risk Prev
https://read.qxmd.com/read/38476538/utilization-of-biomarkers-for-the-prognostic-prediction-of-cardiac-arrest-survivors-using-a-multi-modal-approach
#19
JOURNAL ARTICLE
Changshin Kang, Yeonho You, Jung Soo Park, Byeong Kwon Park, Jae Kwang Lee, Byung Kook Lee
No abstract text is available yet for this article.
2024: World Journal of Emergency Medicine
https://read.qxmd.com/read/38476379/prediction-of-acute-kidney-injury-after-cardiac-surgery-with-fibrinogen-to-albumin-ratio-a-prospective-observational-study
#20
JOURNAL ARTICLE
Wang Xu, Xin Ouyang, Yingxin Lin, Xue Lai, Junjiang Zhu, Zeling Chen, Xiaolong Liu, Xinyi Jiang, Chunbo Chen
BACKGROUND: The occurrence of acute kidney injury (AKI) following cardiac surgery is common and linked to unfavorable consequences while identifying it in its early stages remains a challenge. The aim of this research was to examine whether the fibrinogen-to-albumin ratio (FAR), an innovative inflammation-related risk indicator, has the ability to predict the development of AKI in individuals after cardiac surgery. METHODS: Patients who underwent cardiac surgery from February 2023 to March 2023 and were admitted to the Cardiac Surgery Intensive Care Unit of a tertiary teaching hospital were included in this prospective observational study...
2024: Frontiers in Cardiovascular Medicine
keyword
keyword
57927
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.