Cho-Long Kim, Su-Bin Lim, Sue-Hee Choi, Dong Hyun Kim, Ye Eun Sim, Eun-Hye Jo, Keeeun Kim, Keesook Lee, Hee-Sae Park, Su Bin Lim, Li-Jung Kang, Han-Sol Jeong, Youngsoo Lee, Carsten G Hansen, Jung-Soon Mo
The Hippo pathway's main effector, Yes-associated protein (YAP), plays a crucial role in tumorigenesis as a transcriptional coactivator. YAP's phosphorylation by core upstream components of the Hippo pathway, such as mammalian Ste20 kinase 1/2 (MST1/2), mitogen-activated protein kinase kinase kinase kinases (MAP4Ks), and their substrate, large tumor suppressor 1/2 (LATS1/2), influences YAP's subcellular localization, stability, and transcriptional activity. However, recent research suggests the existence of alternative pathways that phosphorylate YAP, independent of these core upstream Hippo pathway components, raising questions about additional means to inactivate YAP...
January 20, 2024: Cell Death & Disease