Concepción Sánchez-Martínez, Liliana Torres-González, Gabriela Alarcón-Galván, Linda E Muñoz-Espinosa, Homero Zapata-Chavira, Diana Patricia Moreno-Peña, Homero Náñez-Terreros, Edelmiro Pérez-Rodríguez, Lourdes Garza-Ocañas, Francisco Javier Guzmán-de la Garza, Paula Andrea Cordero
INTRODUCTION: Essential amino acid α-keto acid analogs are used in the treatment of chronic kidney disease to delay the symptoms of uremia. However, it is unknown whether essential amino acid α-keto acid analogs affect the oxidative stress and the inflammation in acute renal injury such as those produced by ischemia-reperfusion. OBJECTIVE: To evaluate the effect of essential amino acid α-keto acid analogs on renal ischemia-reperfusion injury in Wistar rats. MATERIALS AND METHODS: Rats were divided into 11 groups (n=6/group): Two groups received physiological saline with or without ischemia-reperfusion injury (45 min/24 h), six groups received essential amino acid α-keto acid analogs (400, 800, or 1,200 mg/kg/24 h/7d) with or without ischemia-reperfusion injury (essential amino acid α-keto acid analogs + ischemia-reperfusion), and two groups received allopurinol (50 mg/kg/24 h/7d) with or without ischemia-reperfusion injury...
June 15, 2020: Biomédica: Revista del Instituto Nacional de Salud