Di Chen, Yi-Yu Sun, Lai-Yang Zhou, Xu Han, Shuo Yang, Fei-Yang Hong, Yuan Yuan, Xiao-Hua Wu, Guo-Hui Huang, Yuan-Chi Cheng, Ju Huang, Dong-Fu Feng
Retinal ganglion cells (RGCs), the sole output neurons in the eyes, are vulnerable to diverse insults in many pathological conditions, which can lead to permanent vision dysfunction. However, the molecular and cellular mechanisms that contribute to protecting RGCs and their axons from injuries are not completely known. Here, we identify that Porf-2, a member of the Rho GTPase activating protein gene group, is upregulated in RGCs after optic nerve crush. Knockdown of Porf-2 protects RGCs from apoptosis and promotes long-distance optic nerve regeneration after crush injury in both young and aged mice in vivo...
August 28, 2023: Cell Death & Disease