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Traumatic optic neuropathy

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https://www.readbyqxmd.com/read/29862194/central-retinal-artery-occlusion-and-traumatic-optic-neuropathy-following-blunt-ocular-trauma
#1
Jasmin Zvorničanin, Ferenc Kuhn, Meliha Halilbašić, Zlatko Mušanović
No abstract text is available yet for this article.
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29859721/visual-pathway-injuries-in-pediatric-ocular-trauma-a-survey-of-the-national-trauma-data-bank-from-2008-to-2014
#2
Ryan Gise, Timothy Truong, Afshin Parsikia, Joyce N Mbekeani
BACKGROUND: Traumatic visual pathway injuries are often associated with severe head trauma and can have profound deleterious effects in developing children and their rehabilitation. We sought to elucidate the epidemiology of pediatric visual pathway injuries in the United States. MATERIALS AND METHODS: This study is a retrospective evaluation of pediatric patients (less than 21 years of age) with visual pathway injuries that were submitted to the National Trauma Data Bank between 2008 to 2014...
April 19, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29847652/rgc-neuroprotection-following-optic-nerve-trauma-mediated-by-intranasal-delivery-of-amnion-cell-secretome
#3
Gabriela A Grinblat, Reas S Khan, Kimberly Dine, Howard Wessel, Larry Brown, Kenneth S Shindler
Purpose: Intranasally delivered ST266, the biological, proteinaceous secretome of amnion-derived multipotent progenitor cells, reduces retinal ganglion cell (RGC) loss, optic nerve inflammation, and demyelination in experimental optic neuritis. This unique therapy and novel administration route delivers numerous cytokines and growth factors to the eye and optic nerve, suggesting a potential to also treat other optic neuropathies. Thus, ST266-mediated neuroprotection was examined following traumatic optic nerve injury...
May 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29797995/-a-212-cases-analysis-of-treatment-for-traumatic-optic-neuropathy-by-nasal-endoscopic-opticnerve-decompression
#4
M Chen, Y Jiang, W H Pang, N Li, Y Z Niu, H Zhao
Objective: To explore the clinical features and therapeutic efficacy of nasal endoscopic optic nerve decompression for traumatic optic neuropathy (TON)treatment. Method: Two hundred and twelve cases (217 eyes) with TON were retrospectively analyzed in our study, who were treated with nasal endoscopic optic nerve decompression in our institution from 1999 to 2016. χ ² -test was used to explore the potential prognostic factors on visual acuity. Result: All patients were followed up from 6 months to 2 years postoperatively, and the effective rate was 54...
September 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29786012/navigation-guided-optic-canal-decompression-for-traumatic-optic-neuropathy-two-case-reports
#5
Kasturi Bhattacharjee, Samir Serasiya, Deepika Kapoor, Harsha Bhattacharjee
Two cases of traumatic optic neuropathy presented with profound loss of vision. Both cases received a course of intravenous corticosteroids elsewhere but did not improve. They underwent Navigation guided optic canal decompression via external transcaruncular approach, following which both cases showed visual improvement. Postoperative Visual Evoked Potential and optical coherence technology of Retinal nerve fibre layer showed improvement. These case reports emphasize on the role of stereotactic navigation technology for optic canal decompression in cases of traumatic optic neuropathy...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29774191/traumatic-optic-neuropathy
#6
REVIEW
Sun Young Jang
Traumatic optic neuropathy (TON) refers to optic nerve injury resulting from direct and indirect head and facial trauma. The pathogenesis of indirect TON has not been fully elucidated, and the management of TON remains controversial. In this review article, I review the recent literature regarding TON and discuss how to manage indirect TON.
April 2018: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29746557/optic-tract-injury-after-closed-head-traumatic-brain-injury-in-mice-a-model-of-indirect-traumatic-optic-neuropathy
#7
Nathan K Evanson, Fernanda Guilhaume-Correa, James P Herman, Michael D Goodman
Adult male C57BL/6J mice have previously been reported to have motor and memory deficits after experimental closed head traumatic brain injury (TBI), without associated gross pathologic damage or neuroimaging changes detectable by magnetic resonance imaging or diffusion tensor imaging protocols. The presence of neurologic deficits, however, suggests neural damage or dysfunction in these animals. Accordingly, we undertook a histologic analysis of mice after TBI. Gross pathology and histologic analysis using Nissl stain and NeuN immunohistochemistry demonstrated no obvious tissue damage or neuron loss...
2018: PloS One
https://www.readbyqxmd.com/read/29720335/iatrogenic-traumatic-optic-neuropathy-report-of-an-injury-occurring-during-a-choanal-atresia-correction-surgery-treatment
#8
D Bertossi, D Marchioni, M Manuelli, U Tacchino, G Giampaoli, I Dall'Acqua, D De Santis, G Ricciardi, L Lanaro, N Kumar, R Nocini, P F Nocini
We report the case of a 36-year-old adult male patient who came to our attention for the evaluation of a possible iatrogenic injury suffered during the surgical correction of congenital choanal atresia. This case report retraces the patient's medical history and the events lapsed in the peri-operative time analyzing if any malpractice has occurred in causing the amaurosis.
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29719851/an-unforeseeable-complication-posterior-ischemic-optic-neuropathy-after-penetrating-injury-to-the-heart
#9
Joseph J Eid, Brian C Cronin, Susan Seman
Trauma surgeons are currently encountering unusual adverse events after traumatic injuries. Ischemic optic neuropathy is a rare complication that may occur in trauma and burn patients that present in extremis and require massive resuscitation. A 29-year-old male patient sustains a penetrating injury to the heart that required primary repair. He remained hemodynamically stable and required a limited amount of resuscitative fluids and products. Postoperatively, the patient develops acute painless bilateral loss of vision...
April 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29705230/risk-factor-analysis-for-the-outcomes-of-indirect-traumatic-optic-neuropathy-with-no-light-perception-at-initial-visual-acuity-testing
#10
I-Li Lai, Han-Tsung Liao
BACKGROUND: The optimal management of indirect traumatic optic neuropathy (TON) is controversial. We aimed to compare the differences in visual improvement by treatment option in patients presenting with TON and no light perception (NLP). We also wanted to identify any patient-related factors that might favor the use of steroid pulse therapy or optic nerve decompression (OND). METHODS: We retrospectively identified 46 consecutive patients with indirect TON treated at Chang Gung Memorial Hospital between 2007 and 2015...
April 26, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29673800/blindness-after-facial-trauma-epidemiology-incidence-and-risk-factors-a-27-year-cohort-study-of-5708-patients
#11
Panagiotis Stathopoulos, Dimosthenis Igoumenakis, Michalis Mezitis, George Rallis
OBJECTIVES: This was a 27-year study of a cohort of 5708 patients who had sustained maxillofacial fractures. Our purpose was to present the etiology, mechanism of trauma, site, and concomitant injuries that led to visual loss. We hypothesize that fractures caused by high-energy impact of the midface may be associated with blindness. A discussion of the treatment approaches is also included. STUDY DESIGN: The study included 5708 patients who had sustained a maxillofacial fracture during the years 1985-2012...
March 23, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29467804/clinical-evaluation-and-treatment-outcome-of-traumatic-optic-neuropathy-in-nepal-a-retrospective-case-series
#12
Sanjeeta Sitaula, Hira Nath Dahal, Ananda Kumar Sharma
This study aims to report the clinical features and role of different treatment modalities in final visual outcome in traumatic optic neuropathy (TON). The authors retrospectively reviewed the records of patients with TON over 4 years. There were 37 patients of unilateral TON. Mean age was 28.70 ± 15.20 years (range: 8-90) and 89% ( n = 33) were males. Road traffic accident was the common cause (43.2%), followed by fall injury (35.1%). There was improvement of visual acuity in 51.4% ( n = 19) cases. Out of different treatment modalities, high-dose intravenous methylprednisolone (1 g/day) led to significant improvement in final visual acuity ( p = 0...
February 2018: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29456943/transnasal-endoscopic-optic-nerve-decompression-in-post-traumatic-optic-neuropathy
#13
Devang Gupta, Monica Gadodia
To quantify the successful outcome in patients following optic nerve decompression in post traumatic unilateral optic neuropathy in form of improvement in visual acuity. A prospective study was carried out over a period of 5 years (January 2011 to June 2016) at civil hospital Ahmedabad. Total 20 patients were selected with optic neuropathy including patients with direct and indirect trauma to unilateral optic nerve, not responding to conservative management, leading to optic neuropathy and subsequent impairment in vision and blindness...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29280766/optic-nerve-avulsion-after-finger-poke-injury
#14
Tapan P Patel, Erica L Archer, Jonathan D Trobe
We present a case of optic nerve avulsion as a result of finger-poke injury to the eye. Spectral domain optical coherence tomography demonstrated a plunging cup indicative of the avulsion, a finding not previously described. Optic nerve avulsion is a form of anterior indirect traumatic optic neuropathy evoked by a sudden severe rotation at the junction of the optic nerve and globe induced, in this case, by penetration of the finger into the nasal orbit.
March 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29260500/baseline-demographics-clinical-features-and-treatment-protocols-of-240-patients-with-optic-neuropathy-experiences-from-a-neuro-ophthalmological-clinic-in-the-aegean-region-of-turkey
#15
Omer Karti, Dilek Top Karti, İlay Hilal Kilic, Figen Gokcay, Nese Celebisoy
PURPOSE: To analyze the demographic patterns, clinical characteristics, and treatment protocols of optic neuropathies. MATERIALS AND METHODS: The hospital data of patients with optic neuropathy admitted to the Department of Neuro-ophthalmology in a tertiary referral center in Turkey between January 2010 to January 2017 were retrospectively analyzed. Demographic patterns, clinical features, treatment protocols, and the natural disease courses were assessed. RESULTS: The total number of patients with optic neuropathy seen over this period was 240, which consist of 43 with idiopathic optic neuritis (17...
December 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29164563/melatonin-regulates-traumatic-optic-neuropathy-via-targeting-autophagy
#16
J Wei, L-S Ma, D-J Liu, J Guo, W-K Jiang, H-J Yu
OBJECTIVE: Traumatic optic neuropathy (TON) usually refers to the indirect damage to the optical nerve, which can cause partial or complete blindness. Melatonin (MT) is a kind of indole hormone, and the retina is one of its natural sites of secretion in the human body. This study aims to explore MT in the retina and optic nerve injuries due to TON. MATERIALS AND METHODS: Sprague-Dawley (SD) rats were used for TON model in the study. After operation, rats were treated with MT or phosphate buffered saline (PBS) for 4, 7, 14, 21, and 28 days before sacrifice...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29156847/longitudinal-relationship-between-traumatic-brain-injury-and-the-risk-of-incident-optic-neuropathy-a-10-year-follow-up-nationally-representative-taiwan-survey
#17
Ying-Jen Chen, Chang-Min Liang, Ming-Cheng Tai, Yun-Hsiang Chang, Tzu-Yu Lin, Chi-Hsiang Chung, Fu-Huang Lin, Chang-Huei Tsao, Wu-Chien Chien
Accumulating evidences had shown that traumatic brain injury was associated with visual impairment or vision loss. However, there were a limited number of empirical studies regarding the longitudinal relationship between traumatic brain injury and incident optic neuropathy. We studied a cohort from the Taiwanese National Health Insurance data comprising 553918 participants with traumatic brain injury and optic neuropathy-free in the case group and 1107836 individuals without traumatic brain injury in the control group from 1st January 2000...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135814/neuro-ophthalmology-at-a-tertiary-eye-care-centre-in-india
#18
Rebika Dhiman, Digvijay Singh, Shiva P Gantayala, Vaitheeswaran L Ganesan, Pradeep Sharma, Rohit Saxena
BACKGROUND: Neuro-ophthalmology as a specialty is underdeveloped in India. The aim of our study was to determine the spectrum and profile of patients presenting to a tertiary eye care center with neuro-ophthalmic disorders. METHODS: A retrospective hospital-based study was conducted, and records of all patients seen at the neuro-ophthalmology clinic of Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, over a 1-year period were retrieved and evaluated...
November 9, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29055368/simultaneous-traumatic-central-retinal-artery-occlusion-and-optic-neuropathy
#19
Mark P Breazzano, Janice C Law, Patrick J Lavin
No abstract text is available yet for this article.
November 2017: Ophthalmology
https://www.readbyqxmd.com/read/28986670/traumatic-optic-neuropathy-treatment-trial-tontt-open-label-phase-3-multicenter-semi-experimental-trial
#20
RANDOMIZED CONTROLLED TRIAL
Mohsen Bahmani Kashkouli, Sahar Yousefi, Marzieh Nojomi, Mostafa Soltan Sanjari, Farzad Pakdel, Morteza Entezari, Mohammad Etezad-Razavi, Mohammad Reza Razeghinejad, Manuchehr Esmaeli, Masoud Shafiee, Mansoureh Bagheri
PURPOSE: Intravenously administered erythropoietin (EPO) was firstly commenced (phase 1) in patients with indirect traumatic optic neuropathy (TON) by this group in 2011. It was re-tested by another group (phase 2) in 2014. This multicenter clinical trial was designed to compare its effect with intravenous steroid and observation. METHODS: Included were TON patients ≥5 years of age and with trauma-treatment interval of ≤3 weeks. Follow-up visits were set at 1, 2, 3, 7, 14, 30, and at least 90 days after treatment...
January 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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