keyword
MENU ▼
Read by QxMD icon Read
search

Traumatic optic neuropathy

keyword
https://www.readbyqxmd.com/read/28986670/traumatic-optic-neuropathy-treatment-trial-tontt-open-label-phase-3-multicenter-semi-experimental-trial
#1
Mohsen Bahmani Kashkouli, Sahar Yousefi, Marzieh Nojomi, Mostafa Soltan Sanjari, Farzad Pakdel, Morteza Entezari, Mohammad Etezad-Razavi, Mohammad Reza Razeghinejad, Manuchehr Esmaeli, Masoud Shafiee, Mansoureh Bagheri
PURPOSE: Intravenously administered erythropoietin (EPO) was firstly commenced (phase 1) in patients with indirect traumatic optic neuropathy (TON) by this group in 2011. It was re-tested by another group (phase 2) in 2014. This multicenter clinical trial was designed to compare its effect with intravenous steroid and observation. METHODS: Included were TON patients ≥5 years of age and with trauma-treatment interval of ≤3 weeks. Follow-up visits were set at 1, 2, 3, 7, 14, 30, and at least 90 days after treatment...
October 6, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28969695/together-jun-and-ddit3-chop-control-retinal-ganglion-cell-death-after-axonal-injury
#2
Stephanie B Syc-Mazurek, Kimberly A Fernandes, Michael P Wilson, Peter Shrager, Richard T Libby
BACKGROUND: Optic nerve injury is an important pathological component in neurodegenerative diseases such as traumatic optic neuropathies and glaucoma. The molecular signaling pathway(s) critical for retinal ganglion cell (RGC) death after axonal insult, however, is/are not fully defined. RGC death after axonal injury is known to occur by BAX-dependent apoptosis. Two transcription factors JUN (the canonical target of JNK) and DDIT3 (CHOP; a key mediator of the endoplasmic reticulum stress response) are known to be important apoptotic signaling molecules after axonal injury, including in RGCs...
October 2, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28937859/choroidal-thickness-in-traumatic-optic-neuropathy
#3
Ju-Yeun Lee, Doo-Ri Eo, Kyung-Ah Park, Sei Yeul Oh
PURPOSE: To examine the choroidal thickness in patients with indirect traumatic optic neuropathy (TON) Methods: Patients with unilateral traumatic optic neuropathy over a period of 4 years were included in this study. Horizontal and vertical enhanced-depth imaging (EDI) from spectral-domain optical coherence tomography (SD-OCT) scans of the fovea were obtained in patients with unilateral TON within 2 weeks of injury. The main outcome measure was the choroidal thickness at nine locations...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28924145/a-novel-mouse-model-of-traumatic-optic-neuropathy-using-external-ultrasound-energy-to-achieve-focal-indirect-optic-nerve-injury
#4
Wensi Tao, Galina Dvoriantchikova, Brian C Tse, Steven Pappas, Tsung-Han Chou, Manuel Tapia, Vittorio Porciatti, Dmitry Ivanov, David T Tse, Daniel Pelaez
Traumatic optic neuropathy (TON) is a devastating cause of permanent visual loss following blunt injury to the head. Animal models for TON exist, but most fail to recapitulate the clinical scenario of closed head indirect trauma to the nerve and subsequent neurodegeneration. Thus, we developed a clinically-relevant animal model for TON using a novel ultrasonic pulse injury modality (sonication-induced TON; SI-TON). To trigger TON, a microtip probe sonifier was placed on the supraorbital ridge directly above the entrance of the optic nerve into the bony canal...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910889/-clinical-features-of-traumatic-optic-neuropathy-in-265-cases
#5
M Chen, Y Jiang, J F Wen, N Li, J Qiu, N K Zhang, J B Ju
Objective: To analyze the clinical features and the pathogenetic law of traumatic optic neuropathy through epidemiologic study. Methods: 265 cases (275 eyes) with TON treated in Department of Otorhinolaryngology Head and Neck Surgery, the Affiliated Hospital of Qingdao University from April 1999 to August 2015 were retrospectively analyzed. Multiple Logistic regression analyses were used to evaluate potential prognostic factors on visual acuity. Results: TON occured mostly in young (194/265, 73.21%) man (235/265, 88...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28761115/hypothermia-prevents-retinal-damage-generated-by-optic-nerve-trauma-in-the-rat
#6
Manuel Rey-Funes, Ignacio M Larrayoz, Daniela S Contartese, Manuel Soliño, Anibal Sarotto, Martín Bustelo, Martín Bruno, Verónica B Dorfman, César F Loidl, Alfredo Martínez
Ocular and periocular traumatisms may result in loss of vision. Hypothermia provides a beneficial intervention for brain and heart conditions and, here, we study whether hypothermia can prevent retinal damage caused by traumatic neuropathy. Intraorbital optic nerve crush (IONC) or sham manipulation was applied to male rats. Some animals were subjected to hypothermia (8 °C) for 3 h following surgery. Thirty days later, animals were subjected to electroretinography and behavioral tests. IONC treatment resulted in amplitude reduction of the b-wave and oscillatory potentials of the electroretinogram, whereas the hypothermic treatment significantly (p < 0...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28726788/neuroprotection-by-eif2%C3%AE-chop-inhibition-and-xbp-1-activation-in-eae-optic-neuritiss
#7
Haoliang Huang, Linqing Miao, Feisi Liang, Xiaodong Liu, Lin Xu, Xiuyin Teng, Qizhao Wang, William H Ridder, Kenneth S Shindler, Yang Sun, Yang Hu
No therapies exist to prevent neuronal deficits in multiple sclerosis (MS), because the molecular mechanism responsible for the progressive neurodegeneration is unknown. We previously showed that axon injury-induced neuronal endoplasmic reticulum (ER) stress plays an important role in retinal ganglion cell (RGC) death and optic nerve degeneration in traumatic and glaucomatous optic neuropathies. Optic neuritis, one of the most common clinical manifestations of MS, is readily modeled by experimental autoimmune encephalomyelitis (EAE) in mouse...
July 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28681279/risk-factors-affecting-the-visual-outcome-in-patients-with-indirect-traumatic-optic-neuropathy
#8
Nazife Sefi-Yurdakul, Feray Koç
PURPOSE: To evaluate the etiology and possible prognostic factors affecting the visual outcome in patients with indirect traumatic optic neuropathy (TON). METHODS: The records of patients with indirect TON were reviewed and compared the results of treatment with high doses of corticosteroids (Group 1) and simple observation without treatment (Group 2). RESULTS: The mean age at the time of injury was 34.7 ± 11.4 (18-58) years in Group 1 and 37...
July 5, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28590394/the-outcome-of-endoscopic-optic-nerve-decompression-for-bilateral-traumatic-optic-neuropathy
#9
Daoyu Xie, Hailing Yu, Jianbao Ju, Li Zhang
OBJECTIVE: To investigate the outcomes of endoscopic optic nerve decompression (EOND) for bilateral traumatic optic neuropathy (TON). METHODS: A retrospective analysis was conducted in 5 patients with bilateral TON, between January 2003 and December 2013. All the patients underwent preoperative ophthalmological evaluation, flash visual-evoked potentials, computed tomography scan, and systemic corticosteroid therapy. All the patients required an EOND surgery, due to poor response to medical therapy, and the remainder one was only treated with corticosteroid due to operative contraindication...
June 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28527030/intravitreal-erythropoietin-injection-in-late-stage-optic-neuropathy-a-safety-study-on-human
#10
Ugur Acar, Bekir Kucuk, Mehmet Koray Sevinc, Seckin Aykas, Mesut Erdurmus, Gungor Sobaci
AIM: To evaluate the whether intravitreal erythropoietin (EPO) administration has any beneficial or adverse effect in patients with late-stage optic neuropathy (ON) or not. METHODS: The study examined 16 eyes of 16 patients who had late-stage ON and ≥1/20 best-corrected visual acuity (BCVA) in their affected eye. There were nonarteritic ischemic ON in 10 (62.5%) eyes, traumatic ON in 4 (25.0%) eyes and methanol-induced ON in 2 (12.5%) eyes. Using pars plana approach, 2000 IU/0...
May 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28439168/ocular-injuries-in-patients-of-zygomatico-complex-zmc-fractures
#11
Altaf Hussain Malik, Aijaz A Shah, Irshad Ahmad, Babar Ai Shah
PURPOSE: Mid face injuries commonly destroy the integrity of the orbital skeleton, and are frequently complicated by injury to the eye, ranging between 2.7 and 90.6 % as reported in literature. The eye injuries range from simple subconjunctival haemorrhage to globe rupture. The paper aims to study the types of ocular injuries in patients with ZMC fractures. PATIENTS AND METHODS: A study of 67 patients, who had sustained facial trauma sufficient to lead to a facial bone fracture, was undertaken in the department of Oral and Maxillofacial Surgery, Govt Dental College, Srinagar from 2008 to 2014 and the patients received a comprehensive examination by an ophthalmologist within 1 week of injury...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28395494/-diagnosis-and-treatment-of-traumatic-optic-neuropathy-with-internal-carotid-artery-trauma
#12
Q J Fan, L Y Ni, X J Liu, Y Zeng, L F Jiang, B Zheng
Objective: To summarize our experience in the diagnosis of internal carotid artery trauma in patients with traumatic optic neuropathy, and to make recommendations for the treatment. Methods: The clinic data of 6 cases who had traumatic optic neuropathy with internal carotid artery trauma and who were admited in Department of Otorhinolaryngology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University from Jan. 2013 to Dec. 2015 were analyzed retrospectively. Results: All 6 cases were monocular blindness...
March 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28339414/update-on-the-application-of-optic-nerve-sheath-fenestration
#13
Hui Chen, Qian Zhang, Song Tan, Huazhu Fu, Bradley K Farris, Zhenglin Yang
BACKGROUND: With the ongoing development of surgical procedures and instruments, the safety of optic nerve sheath fenestration (ONSF) has been improved. OBJECTIVE: Through the past three decades, progress has been made in preventing visual loss from chronic optic nerve swelling in idiopathic intracranial hypertension (IIH), secondary intracranial hypertension and local optic nerve diseases. We now review the updated application of ONSF in those diseases. METHODS: The application of ONSF in papilledema due to IIH, secondary intracranial hypertension to cerebral venous sinus occlusion, Cryptococcal meningitis, and intracranial mass or tumors is reviewed...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28291071/circinate-partition-like-findings-on-cone-mosaic-imaged-by-adaptive-optics-scanning-laser-ophthalmoscopy-in-eyes-with-inner-nuclear-layer-microcystic-changes
#14
Tomoko Hasegawa, Sotaro Ooto, Yukiko Makiyama, Masayuki Hata, Kazuaki Miyamoto, Nagahisa Yoshimura
PURPOSE: To report cases that showed partition-like, dark areas in the cone mosaic on adaptive optics scanning laser ophthalmoscopy (AO-SLO) images in eyes with inner nuclear layer (INL) microcystic changes. METHODS: Eyes with INL microcystic changes were imaged by prototype AO-SLO. RESULTS: An eye with Leber hereditary optic neuropathy, an eye with traumatic optic neuropathy, and an eye with retinitis pigmentosa that showed microcystic lesions in the INL were imaged by AO-SLO...
March 13, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28198592/bone-marrow-derived-mesenchymal-stem-cells-derived-exosomes-promote-survival-of-retinal-ganglion-cells-through-mirna-dependent-mechanisms
#15
Ben Mead, Stanislav Tomarev
The loss of retinal ganglion cells (RGC) and their axons is one of the leading causes of blindness and includes traumatic (optic neuropathy) and degenerative (glaucoma) eye diseases. Although no clinical therapies are in use, mesenchymal stem cells (MSC) have demonstrated significant neuroprotective and axogenic effects on RGC in both of the aforementioned models. Recent evidence has shown that MSC secrete exosomes, membrane enclosed vesicles (30-100 nm) containing proteins, mRNA and miRNA which can be delivered to nearby cells...
April 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28192386/spectrum-of-magnetic-resonance-imaging-features-in-unilateral-optic-tract-dysfunction
#16
Kristopher M Kowal, Francisco F Rivas Rodriguez, Ashok Srinivasan, Jonathan D Trobe
BACKGROUND: Optic tract dysfunction may be the predominant or only clinical manifestation of an intracranial disorder including mass legion, ischemic infarct, inflammatory disease, and trauma. Documentation of the neuroimaging features of these lesions is limited to reports mostly published before the availability of MRI. This study was undertaken to document the spectrum of MRI features in patients presenting with optic tract dysfunction. METHODS: A retrospective study from 2004 to 2015 at a single tertiary care neuro-ophthalmology service of 24 patients who had unilateral optic tract dysfunction defined by a homonymous hemianopia and a relative afferent pupil defect that could not be attributed to optic neuropathy or retinopathy...
March 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28187873/-erratum-to-traumatic-optic-neuropathy-report-of-8%C3%A2-cases-and-review-of-the-literature-j-fr-ophtalmol-39-7-2016-603-8
#17
A Le Guern, C Marks-Delesalle, L Borry, J Chekroun, C Ciocanea, C Gruchala, L Gogneaux, A Lossouarn, J-G Mery, L Nielloud, V Vasseur, S Defoort-Dhelemmes
No abstract text is available yet for this article.
February 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28186701/bone-marrow-derived-mesenchymal-stem-cells-derived-exosomes-promote-survival-of-retinal-ganglion-cells-through-mirna-dependent-mechanisms
#18
Ben Mead, Stanislav Tomarev
The loss of retinal ganglion cells (RGC) and their axons is one of the leading causes of blindness and includes traumatic (optic neuropathy) and degenerative (glaucoma) eye diseases. Although no clinical therapies are in use, mesenchymal stem cells (MSC) have demonstrated significant neuroprotective and axogenic effects on RGC in both of the aforementioned models. Recent evidence has shown that MSC secrete exosomes, membrane enclosed vesicles (30-100 nm) containing proteins, mRNA and miRNA which can be delivered to nearby cells...
January 26, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28164440/effect-of-human-umbilical-cord-blood-mesenchymal-stem-cells-administered-by-intravenous-or-intravitreal-routes-on-cryo-induced-retinal-injury
#19
Eman M Mohamed, Shaimaa A Abdelrahman, Samia Hussein, Sally M Shalaby, Hala Mosaad, Ahmed M B Awad
Traumatic optic neuropathy is an important cause of severe vision loss. So, many attempts were performed to transplant stem cells systemically or locally to regenerate the injured retina. In this study, we investigated the effect of human umbilical cord blood mesenchymal stem cells (hUBMSCs) on histological structure, apoptotic, antiapoptotic, oxidant and antioxidant markers in an experimental model of cryo-induced retinal damage in mice. Forty-eight mice were included with 4 major groups; group I contained 18 mice as controls...
March 2017: IUBMB Life
https://www.readbyqxmd.com/read/28088936/endoscopic-decompression-of-the-optic-canal-for-traumatic-optic-neuropathy
#20
Zhen-Hua He, Zheng-Bo Lan, Ao Xiong, Guo-Kuo Hou, Ya-Wen Pan, Qiang Li, Xin-Ding Zhang
PURPOSE: Traumatic optic neuropathy (TON) is a serious complication of head trauma with the incidence rate of 0.5%-5%. The aim of this study was to investigate the therapeutic efficacy of endoscopic decompression of the optic canal for optic nerve injuries. METHODS: In this study, 11 patients treated in our hospital from January 2009 to January 2015 with the visual loss resulting from TON were retrospectively reviewed for preoperative vision, visual evoked potential (VEP) scan, surgical approach, postoperative visual acuity, complications, and follow-up results...
December 1, 2016: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
keyword
keyword
57922
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"