Ajay K Verma, Bharadwaj Nandakumar, Kit Acedillo, Ying Yu, Ethan Marshall, David Schneck, Mark Fiecas, Jing Wang, Colum D MacKinnon, Michael J Howell, Jerrold L Vitek, Luke A Johnson
Increasing evidence suggests slow-wave sleep (SWS) dysfunction in Parkinson's disease (PD) is associated with faster disease progression, cognitive impairment, and excessive daytime sleepiness. Beta oscillations (8-35 Hz) in the basal ganglia thalamocortical (BGTC) network are thought to play a role in the development of cardinal motor signs of PD. The role cortical beta oscillations play in SWS dysfunction in the early stage of parkinsonism is not understood, however. To address this question, we used a within-subject design in a nonhuman primate (NHP) model of PD to record local field potentials from the primary motor cortex (MC) during sleep across normal and mild parkinsonian states...
2024: Frontiers in Neuroscience