keyword
MENU ▼
Read by QxMD icon Read
search

thalamocortical network

keyword
https://www.readbyqxmd.com/read/27919294/heantos-4-a-natural-plant-extract-used-in-the-treatment-of-drug-addiction-modulates-t-type-calcium-channels-and-thalamocortical-burst-firing
#1
Stuart M Cain, Soyon Ahn, Esperanza Garcia, Yiming Zhang, Zeina Waheed, John R Tyson, Yi Yang, Tran Van Sung, Anthony G Phillips, Terrance P Snutch
Heantos-4 is a refined combination of plant extracts currently approved to treat opiate addiction in Vietnam. In addition to its beneficial effects on withdrawal and prevention of relapse, reports of sedation during clinical treatment suggest that arousal networks in the brain may be recruited during Heantos administration. T-type calcium channels are implicated in the generation of sleep rhythms and in this study we examined whether a Heantos-4 extraction modulates T-type calcium channel currents generated by the Cav3...
December 5, 2016: Molecular Brain
https://www.readbyqxmd.com/read/27902865/small-world-properties-changes-in-mild-traumatic-brain-injury
#2
Yongxia Zhou
PURPOSE: To investigate local and global efficiency changes characterized by small-world properties based on resting-state functional MRI, such as centrality and clustering coefficient, in mild traumatic brain injury (MTBI) patients; and to associate these findings with axonal injury as measured by diffusion tensor imaging (DTI) as well as with post-concussive symptom (PCS). MATERIALS AND METHODS: Thirty patients (mean age 35 ± 13 years) with clinically defined MTBI and 45 age-matched healthy controls (mean age 37 ± 10 years) participated in the experiments...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27883901/tapping-the-brakes-cellular-and-synaptic-mechanisms-that-regulate-thalamic-oscillations
#3
REVIEW
P Michelle Fogerson, John R Huguenard
Thalamic oscillators contribute to both normal rhythms associated with sleep and anesthesia and abnormal, hypersynchronous oscillations that manifest behaviorally as absence seizures. In this review, we highlight new findings that refine thalamic contributions to cortical rhythms and suggest that thalamic oscillators may be subject to both local and global control. We describe endogenous thalamic mechanisms that limit network synchrony and discuss how these protective brakes might be restored to prevent absence seizures...
November 23, 2016: Neuron
https://www.readbyqxmd.com/read/27876879/stimulus-induced-epileptic-spike-wave-discharges-in-thalamocortical-model-with-disinhibition
#4
Denggui Fan, Suyu Liu, Qingyun Wang
Epileptic absence seizure characterized by the typical 2-4 Hz spike-wave discharges (SWD) are known to arise due to the physiologically abnormal interactions within the thalamocortical network. By introducing a second inhibitory neuronal population in the cortical system, here we propose a modified thalamocortical field model to mathematically describe the occurrences and transitions of SWD under the mutual functions between cortex and thalamus, as well as the disinhibitory modulations of SWD mediated by the two different inhibitory interneuronal populations...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27860375/differential-impairment-of-thalamocortical-structural-connectivity-in-amyotrophic-lateral-sclerosis
#5
Jiu-Quan Zhang, Bing Ji, Chao-Yang Zhou, Long-Chuan Li, Zhi-Hao Li, Xiao-Ping Hu, Jun Hu
AIMS: The thalamus is a major relay station that modulates input from many cortical areas and a filter for sensory input and is involved in the pathophysiology of amyotrophic lateral sclerosis (ALS). However, it still remains unclear whether all thalamocortical networks are affected or whether there is selective vulnerability. In this study, we aimed to study the selective vulnerability of different thalamocortical structural connections in ALS and to test the hypothesis of a specific impairment in motor-related thalamocortical connectivity...
November 12, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27855061/rotating-waves-during-human-sleep-spindles-organize-global-patterns-of-activity-that-repeat-precisely-through-the-night
#6
Lyle Muller, Giovanni Piantoni, Dominik Koller, Sydney S Cash, Eric Halgren, Terrence J Sejnowski
During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops. Spindles have been increasingly demonstrated to be critical for sleep-dependent consolidation of memory, but the specific neural mechanism for this process remains unclear. We show here that cortical spindles are spatiotemporally organized into circular wave-like patterns, organizing neuronal activity over tens of milliseconds, within the timescale for storing memories in large-scale networks across the cortex via spike-time dependent plasticity...
November 15, 2016: ELife
https://www.readbyqxmd.com/read/27849520/cellular-and-neurochemical-basis-of-sleep-stages-in-the-thalamocortical-network
#7
Giri P Krishnan, Sylvain Chauvette, Isaac Shamie, Sara Soltani, Igor Timofeev, Sydney S Cash, Eric Halgren, Maxim Bazhenov
The link between the combined action of neuromodulators in the brain and global brain states remains a mystery. In this study, using biophysically realistic models of the thalamocortical network, we identified the critical intrinsic and synaptic mechanisms, associated with the putative action of acetylcholine (ACh), GABA and monoamines, which lead to transitions between primary brain vigilance states (waking, non-rapid eye movement sleep [NREM] and REM sleep) within an ultradian cycle. Using ECoG recordings from humans and LFP recordings from cats and mice, we found that during NREM sleep the power of spindle and delta oscillations is negatively correlated in humans and positively correlated in animal recordings...
November 16, 2016: ELife
https://www.readbyqxmd.com/read/27837401/collection-of-simulated-data-from-a-thalamocortical-network-model
#8
Helena Głąbska, Chaitanya Chintaluri, Daniel K Wójcik
A major challenge in experimental data analysis is the validation of analytical methods in a fully controlled scenario where the justification of the interpretation can be made directly and not just by plausibility. In some sciences, this could be a mathematical proof, yet biological systems usually do not satisfy assumptions of mathematical theorems. One solution is to use simulations of realistic models to generate ground truth data. In neuroscience, creating such data requires plausible models of neural activity, access to high performance computers, expertise and time to prepare and run the simulations, and to process the output...
November 11, 2016: Neuroinformatics
https://www.readbyqxmd.com/read/27784534/toward-understanding-thalamocortical-dysfunction-in-schizophrenia-through-computational-models-of-neural-circuit-dynamics
#9
REVIEW
John D Murray, Alan Anticevic
The thalamus is implicated in the neuropathology of schizophrenia, and multiple modalities of noninvasive neuroimaging provide converging evidence for altered thalamocortical dynamics in the disorder, such as functional connectivity and oscillatory power. However, it remains a challenge to link these neuroimaging biomarkers to underlying neural circuit mechanisms. One potential path forward is a "Computational Psychiatry" approach that leverages computational models of neural circuits to make predictions for the dynamical impact dynamical impact on specific thalamic disruptions hypothesized to occur in the pathophysiology of schizophrenia...
October 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27739612/structural-and-functional-connectivity-of-the-precuneus-and-thalamus-to-the-default-mode-network
#10
Samantha I Cunningham, Dardo Tomasi, Nora D Volkow
Neuroimaging studies have identified functional interactions between the thalamus, precuneus, and default mode network (DMN) in studies of consciousness. However, less is known about the structural connectivity of the precuneus and thalamus to regions within the DMN. We used diffusion tensor imaging (DTI) to parcellate the precuneus and thalamus based on their probabilistic white matter connectivity to each other and DMN regions of interest (ROIs) in 37 healthy subjects from the Human Connectome Database. We further assessed resting-state functional connectivity (RSFC) among the precuneus, thalamus, and DMN ROIs...
October 14, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27739541/spatiotemporal-properties-of-microsaccades-model-predictions-and-experimental-tests
#11
Jian-Fang Zhou, Wu-Jie Yuan, Zhao Zhou
Microsaccades are involuntary and very small eye movements during fixation. Recently, the microsaccade-related neural dynamics have been extensively investigated both in experiments and by constructing neural network models. Experimentally, microsaccades also exhibit many behavioral properties. It's well known that the behavior properties imply the underlying neural dynamical mechanisms, and so are determined by neural dynamics. The behavioral properties resulted from neural responses to microsaccades, however, are not yet understood and are rarely studied theoretically...
October 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27734895/the-thalamo-cortical-complex-network-correlates-of-chronic-pain
#12
Antonio G Zippo, Maurizio Valente, Gian Carlo Caramenti, Gabriele E M Biella
Chronic pain (CP) is a condition with a large repertory of clinical signs and symptoms with diverse expressions. Though widely analyzed, an appraisal at the level of single neuron and neuronal networks in CP is however missing. The present research proposes an empirical and theoretic framework which identifies a complex network correlate nested in the somatosensory thalamocortical (TC) circuit in diverse CP models. In vivo simultaneous extracellular neuronal electrophysiological high-density recordings have been performed from the TC circuit in rats...
October 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27660609/presence-of-a-chaotic-region-at-the-sleep-wake-transition-in-a-simplified-thalamocortical-circuit-model
#13
Kush Paul, Lawrence J Cauller, Daniel A Llano
Sleep and wakefulness are characterized by distinct states of thalamocortical network oscillations. The complex interplay of ionic conductances within the thalamo-reticular-cortical network give rise to these multiple modes of activity and a rapid transition exists between these modes. To better understand this transition, we constructed a simplified computational model based on physiological recordings and physiologically realistic parameters of a three-neuron network containing a thalamocortical cell, a thalamic reticular neuron, and a corticothalamic cell...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27638061/neurotransmitters-in-the-vestibular-system
#14
C D Balaban
Neuronal networks that are linked to the peripheral vestibular system contribute to gravitoinertial sensation, balance control, eye movement control, and autonomic function. Ascending connections to the limbic system and cerebral cortex are also important for motion perception and threat recognition, and play a role in comorbid balance and anxiety disorders. The vestibular system also shows remarkable plasticity, termed vestibular compensation. Activity in these networks is regulated by an interaction between: (1) intrinsic neurotransmitters of the inner ear, vestibular nerve, and vestibular nuclei; (2) neurotransmitters associated with thalamocortical and limbic pathways that receive projections originating in the vestibular nuclei; and (3) locus coeruleus and raphe (serotonergic and nonserotonergic) projections that influence the latter components...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27629713/the-role-of-striatal-feedforward-inhibition-in-the-maintenance-of-absence-seizures
#15
Takafumi Arakaki, Séverine Mahon, Stéphane Charpier, Arthur Leblois, David Hansel
UNLABELLED: Absence seizures are characterized by brief interruptions of conscious experience accompanied by oscillations of activity synchronized across many brain areas. Although the dynamics of the thalamocortical circuits are traditionally thought to underlie absence seizures, converging experimental evidence supports the key involvement of the basal ganglia (BG). In this theoretical work, we argue that the BG are essential for the maintenance of absence seizures. To this end, we combine analytical calculations with numerical simulations to investigate a computational model of the BG-thalamo-cortical network...
September 14, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27622141/relation-between-functional-connectivity-and-rhythm-discrimination-in-children-who-do-and-do-not-stutter
#16
Soo-Eun Chang, Ho Ming Chow, Elizabeth A Wieland, J Devin McAuley
Our ability to perceive and produce rhythmic patterns in the environment supports fundamental human capacities ranging from music and language processing to the coordination of action. This article considers whether spontaneous correlated brain activity within a basal ganglia-thalamocortical (rhythm) network is associated with individual differences in auditory rhythm discrimination. Moreover, do children who stutter with demonstrated deficits in rhythm perception have weaker links between rhythm network functional connectivity and rhythm discrimination? All children in the study underwent a resting-state fMRI session, from which functional connectivity measures within the rhythm network were extracted from spontaneous brain activity...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27620977/intracortical-network-effects-preserve-thalamocortical-input-efficacy-in-a-cortex-without-layers
#17
Julien Guy, Alexandra Sachkova, Martin Möck, Mirko Witte, Robin J Wagener, Jochen F Staiger
Layer IV (LIV) of the rodent somatosensory cortex contains the somatotopic barrel field. Barrels receive much of the sensory input to the cortex through innervation by thalamocortical axons from the ventral posteromedial nucleus. In the reeler mouse, the absence of cortical layers results in the formation of mispositioned barrel-equivalent clusters of LIV fated neurons. Although functional imaging suggests that sensory input activates the cortex, little is known about the cellular and synaptic properties of identified excitatory neurons of the reeler cortex...
September 12, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27617689/neural-correlates-of-sevoflurane-induced-unconsciousness-identified-by-simultaneous-functional-magnetic-resonance-imaging-and-electroencephalography
#18
Andreas Ranft, Daniel Golkowski, Tobias Kiel, Valentin Riedl, Philipp Kohl, Guido Rohrer, Joachim Pientka, Sebastian Berger, Alexander Thul, Max Maurer, Christine Preibisch, Claus Zimmer, George A Mashour, Eberhard F Kochs, Denis Jordan, Rüdiger Ilg
BACKGROUND: The neural correlates of anesthetic-induced unconsciousness have yet to be fully elucidated. Sedative and anesthetic states induced by propofol have been studied extensively, consistently revealing a decrease of frontoparietal and thalamocortical connectivity. There is, however, less understanding of the effects of halogenated ethers on functional brain networks. METHODS: The authors recorded simultaneous resting-state functional magnetic resonance imaging and electroencephalography in 16 artificially ventilated volunteers during sevoflurane anesthesia at burst suppression and 3 and 2 vol% steady-state concentrations for 700 s each to assess functional connectivity changes compared to wakefulness...
November 2016: Anesthesiology
https://www.readbyqxmd.com/read/27598260/transition-between-functional-regimes-in-an-integrate-and-fire-network-model-of-the-thalamus
#19
Alessandro Barardi, Jordi Garcia-Ojalvo, Alberto Mazzoni
The thalamus is a key brain element in the processing of sensory information. During the sleep and awake states, this brain area is characterized by the presence of two distinct dynamical regimes: in the sleep state activity is dominated by spindle oscillations (7 - 15 Hz) weakly affected by external stimuli, while in the awake state the activity is primarily driven by external stimuli. Here we develop a simple and computationally efficient model of the thalamus that exhibits two dynamical regimes with different information-processing capabilities, and study the transition between them...
2016: PloS One
https://www.readbyqxmd.com/read/27569659/the-quality-of-cortical-network-function-recovery-depends-on-localization-and-degree-of-axonal-demyelination
#20
Manuela Cerina, Venu Narayanan, Kerstin Göbel, Stefan Bittner, Tobias Ruck, Patrick Meuth, Alexander M Herrmann, Martin Stangel, Viktoria Gudi, Thomas Skripuletz, Thiemo Daldrup, Heinz Wiendl, Thomas Seidenbecher, Petra Ehling, Christoph Kleinschnitz, Hans-Christian Pape, Thomas Budde, Sven G Meuth
Myelin loss is a severe pathological hallmark common to a number of neurodegenerative diseases, including multiple sclerosis (MS). Demyelination in the central nervous system appears in the form of lesions affecting both white and gray matter structures. The functional consequences of demyelination on neuronal network and brain function are not well understood. Current therapeutic strategies for ameliorating the course of such diseases usually focus on promoting remyelination, but the effectiveness of these approaches strongly depends on the timing in relation to the disease state...
August 25, 2016: Brain, Behavior, and Immunity
keyword
keyword
57918
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"