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https://www.readbyqxmd.com/read/28324340/quantitative-18-f-fluorocholine-positron-emission-tomography-for-prostate-cancer-correlation-between-kinetic-parameters-and-gleason-scoring
#1
Joshua J D Schaefferkoetter, Ziting Wang, Mary C Stephenson, Sharmili Roy, Maurizio Conti, Lars Eriksson, David W Townsend, Thomas Thamboo, Edmund Chiong
BACKGROUND: The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is not fully understood. Moreover, relatively few studies have investigated the correlation between tracer uptake and histological tumor grade. This work quantified (18)F-fluorocholine in tumor and healthy prostate tissue using pharmacokinetic modeling and stratified uptake parameters by histology grade...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28323714/osteointegration-and-resorption-of-intravertebral-and-extravertebral-calcium-phosphate-cement
#2
Roman Klein, Ralf Tetzlaff, Christel Weiss, Meike-Kristina Schäfer, Michael Tanner, Bernd Wiedenhöfer, Ingo Grafe, Peter-Jürgen Meeder, Gerd Noeldge, Peter P Nawroth, Christian Kasperk
STUDY DESIGN: Eleven patients with painful osteoporotic vertebral fractures who underwent kyphoplasty using calcium phosphate (CaP) cement were followed up for 1 week, 1, 2, and 3 years in a monocentric, nonrandomized, noncontrolled retrospective trial. OBJECTIVE: This study investigates long-term radiomorphologic features of intraosseous CaP cement implants and of extraosseous CaP cement leakages for up to 3 years after implantation by kyphoplasty. SUMMARY OF BACKGROUND DATA: Kyphoplasty is frequently used for the treatment of painful osteoporotic fractures...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323572/bilateral-changes-in-deep-tissue-environment-after-manual-lymphatic-drainage-in-patients-with-breast-cancer-treatment-related-lymphedema
#3
Paula M C Donahue, Rachelle Crescenzi, Allison O Scott, Vaughn Braxton, Aditi Desai, Seth A Smith, John Jordi, Ingrid M Meszoely, Ana M Grau, Rondi M Kauffmann, Raeshell S Sweeting, Kandace Spotanski, Sheila H Ridner, Manus J Donahue
BACKGROUND: Breast cancer treatment-related lymphedema (BCRL) arises from a mechanical insufficiency following cancer therapies. Early BCRL detection and personalized intervention require an improved understanding of the physiological processes that initiate lymphatic impairment. Here, internal magnetic resonance imaging (MRI) measures of the tissue microenvironment were paired with clinical measures of tissue structure to test fundamental hypotheses regarding structural tissue and muscle changes after the commonly used therapeutic intervention of manual lymphatic drainage (MLD)...
March 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28318888/characterization-of-the-lung-parenchyma-using-ultrasound-multiple-scattering
#4
Kaustav Mohanty, John Blackwell, Thomas Egan, Marie Muller
The purpose of the study described here was to showcase the application of ultrasound to quantitative characterization of the micro-architecture of the lung parenchyma to predict the extent of pulmonary edema. The lung parenchyma is a highly complex and diffusive medium for which ultrasound techniques have remained qualitative. The approach presented here is based on ultrasound multiple scattering and exploits the complexity of ultrasound propagation in the lung structure. The experimental setup consisted of a linear transducer array with an 8-MHz central frequency placed in contact with the lung surface...
March 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28318590/supplementation-with-rumen-protected-methionine-or-choline-during-the-transition-period-influences-whole-blood-immune-response-in-periparturient-dairy-cows
#5
M Vailati-Riboni, Z Zhou, C B Jacometo, A Minuti, E Trevisi, D N Luchini, J J Loor
Methionine, together with Lys, is the most limiting AA for milk production in dairy cows. Besides its crucial role in milk production, Met and its derivate metabolites (e.g., glutathione, taurine, polyamines) are well-known immunonutrients in nonruminants, helping support and boost immune function and activity. In the present study, the effects of Met or choline, as its precursor, were investigated using an ex vivo whole blood challenge. The study involved 33 multiparous Holstein cows (from a larger cohort with a factorial arrangement of treatments) assigned from d -21 to +30 relative to parturition to a basal control (CON) diet, CON plus rumen-protected Met (MET, Smartamine M, Adisseo NA, Alpharetta, GA) at a rate of 0...
March 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28317971/on-the-lewis-acidic-character-of-bis-salicylaldiminato-zinc-ii-schiff-base-complexes-a-computational-and-experimental-investigation-on-a-series-of-compounds-varying-the-bridging-diimine
#6
Giuseppe Forte, Ivan Pietro Oliveri, Giuseppe Consiglio, Salvatore Failla, Santo Di Bella
This contribution explores the effect of the 1,2-diimine bridge upon the Lewis acidic character of a series of bis(salicylaldiminato)zinc(ii), ZnL, Schiff-base complexes. The structure of the monomeric and dimeric ZnL complexes, and of the 1 : 1 adducts with pyridine, ZnL·py, is fully optimized by means of DFT calculations. The Gibbs free energy for the dimerization of ZnL complexes and for the formation of ZnL·py adducts is evaluated by accurate composite calculations. It accounts for their spontaneous dimerization and for the greater stability of the ZnL·py adducts with respect to the dimers...
March 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28317128/comparison-of-dce-mri-kinetic-parameters-and-fmiso-pet-uptake-parameters-in-head-and-neck-cancer-patients
#7
Urban Simoncic, Sara Leibfarth, Stefan Welz, Nina Schwenzer, Holger Schmidt, Gerald Reischl, Christina Pfannenberg, Christian la Fougère, Konstantin Nikolaou, Daniel Zips, Daniela Thorwarth
PURPOSE: Tumour hypoxia is a major cause of radiation resistance, often present in various solid tumours. Dynamic [(18) F]-fluoromisonidazole (FMISO) PET imaging is able to reliably assess tumour hypoxia. Comprehensive characterization of tumour microenvironment through FMISO-PET and dynamic contrast enhanced (DCE) MR multimodality imaging might be a valuable alternative to the dynamic FMISO-PET acquisition. The aim of this work was to explore the correlation between the FMISO-PET and DCE-MRI kinetic parameters...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28316067/fisse-a-simple-non-parametric-test-for-the-effects-of-a-binary-character-on-lineage-diversification-rates
#8
Daniel L Rabosky, Emma E Goldberg
It is widely assumed that phenotypic traits can influence rates of speciation and extinction, and several statistical approaches have been used to test for correlations between character states and lineage diversification. Recent work suggests that model-based tests of state-dependent speciation and extinction are sensitive to model inadequacy and phylogenetic pseudoreplication. We describe a simple non-parametric statistical test ("FiSSE") to assess the effects of a binary character on lineage diversification rates...
March 18, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28316046/treatment-of-municipal-wastewater-in-full-scale-on-site-sand-filter-reduces-bod-efficiently-but-does-not-reach-requirements-for-nitrogen-and-phosphorus-removal
#9
Petteri Laaksonen, Aki Sinkkonen, Gennadi Zaitsev, Esa Mäkinen, Timo Grönroos, Martin Romantschuk
A traditional sand filter for treatment of household wastewater was constructed in the fall of 2012 at Biolinja 12, Turku, Finland. Construction work was led and monitored by an authorized wastewater treatment consultant. The filter was placed on a field bordered by open ditches from all sides in order to collect excess rain and snowmelt waters. The filter was constructed and insulated from the environment so that all outflowing water was accounted for. Untreated, mainly municipal, wastewater from Varissuo suburb was pumped from a sewer separately via three septic tanks (volume = 1 m(3) each) into the filters...
March 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28315633/using-simulated-fluorescence-cell-micrographs-for-the-evaluation-of-cell-image-segmentation-algorithms
#10
Veit Wiesmann, Matthias Bergler, Ralf Palmisano, Martin Prinzen, Daniela Franz, Thomas Wittenberg
BACKGROUND: Manual assessment and evaluation of fluorescent micrograph cell experiments is time-consuming and tedious. Automated segmentation pipelines can ensure efficient and reproducible evaluation and analysis with constant high quality for all images of an experiment. Such cell segmentation approaches are usually validated and rated in comparison to manually annotated micrographs. Nevertheless, manual annotations are prone to errors and display inter- and intra-observer variability which influence the validation results of automated cell segmentation pipelines...
March 18, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28315150/radioiodination-and-preclinical-evaluation-of-4-benzyl-1-3-125-i-iodobenzylsulfonyl-piperidine-as-a-breast-tumor-imaging-tracer-in-mouse
#11
Masoud Sadeghzadeh, Behrouz Alirezapour, Ghorban Ali Charkhlooie, Maryam Keshavarz Baghery, Amir Khorouti
OBJECTIVE: 4-Benzyl-1-(3-iodobenzylsulfonyl)piperidine, 4-B-IBSP, has shown high-binding affinity to both sigma (σ) receptors in our previous work. In current study, radiolabeling and preclinical evaluation of 4-benzyl-1-(3-[(125)I]-iodobenzylsulfonyl)piperidine, 4-B-[(125)I]IBSP, in human ductal breast carcinoma (T47D) cells and in breast adenocarcinoma-bearing BALB/c mice are described. METHODS: Radioiodination of this new σ ligand was performed by a palladium-catalyzed stannylation approach followed by oxidative iododestannylation reaction using Iodo-Gen...
March 17, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28306299/graviton-mass-might-reduce-tension-between-early-and-late-time-cosmological-data
#12
Antonio De Felice, Shinji Mukohyama
The standard cold dark matter model with a cosmological constant (Λ-CDM) predicts a growth of structures which tends to be higher than the values of redshift space distortion (RSD) measurements if the cosmological parameters are fixed by the cosmic microwave background data. In this Letter, we point out that this discrepancy can be resolved or understood if we assume that the graviton has a small but nonzero mass. In the context of the minimal theory of massive gravity (MTMG), due to infrared Lorentz violations measurable only at present cosmological scales, the graviton acquires a mass without being haunted by unwanted extra degrees of freedom...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28306265/room-temperature-magneto-dielectric-effect-in-laga0-7fe0-3o3-%C3%AE-origin-and-impact-of-excess-oxygen
#13
Hari Mohan Rai, Preetam Singh, Shailendra K Saxena, Vikash Mishra, M Kamal Warshi, Rajesh Kumar, Parasmani Rajput, Archna Sagdeo, Indrani Choudhuri, Biswarup Pathak, Pankaj R Sagdeo
We report an observation of room-temperature magneto-dielectric (RTMD) effect in LaGa0.7Fe0.3O3+γ compound. The contribution of intrinsic/resistive sources in the presently observed RTMD effect was analyzed by measuring direct-current (dc) magnetoresistance (MR) in four-probe geometry and frequency-dependent MR via impedance spectroscopy (MRIS). Present MRIS analysis reveals that at frequencies corresponding to grain contribution (≥1 × 10(6) Hz for present sample), the observed MD phenomenon is MR-free/intrinsic, whereas at lower probing frequencies (<1 × 10(6) Hz), the observed MD coupling appears to be MR-dominated possibly due to oxygen excess, that is, due to coexistence of Fe(3+) and Fe(4+)...
March 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28306160/new-approach-shows-no-association-between-maternal-milk-fatty-acid-composition-and-childhood-wheeze-or-asthma
#14
Chad A Logan, Stephanie Brandt, Martin Wabitsch, Hermann Brenner, Frank Wiens, Bernd Stahl, Tamás Marosvölgyi, Tamás Decsi, Dietrich Rothenbacher, Jon Genuneit
BACKGROUND: Previous observational studies have implied breast milk fatty acid composition may play a role in development of atopic eczema or atopic sensitization in breastfed infants and toddlers. However, studies investigating associations with wheeze and asthma in later childhood are scarce and did not account for inherent correlation of compositional data. Our aim was to explore the association of maternal milk fatty acid composition with childhood wheezing phenotypes and asthma up to age 13 years using a new statistical approach...
March 17, 2017: Allergy
https://www.readbyqxmd.com/read/28304330/a-context-aware-s-health-service-system-for-drivers
#15
Jingkun Chang, Wenbin Yao, Xiaoyong Li
As a stressful and sensitive task, driving can be disturbed by various factors from the health condition of the driver to the environmental variables of the vehicle. Continuous monitoring of driving hazards and providing the most appropriate business services to meet actual needs can guarantee safe driving and make great use of the existing information resources and business services. However, there is no in-depth research on the perception of a driver's health status or the provision of customized business services in case of various hazardous situations...
March 17, 2017: Sensors
https://www.readbyqxmd.com/read/28304068/high-velocity-proton-collision-with-liquid-lithium-a-time-dependent-density-functional-theory-study
#16
Gang Bi, Jun Kang, Lin-Wang Wang
Liquid lithium is often used as a coating material in fusion reaction chambers, where it is under constant bombardment from high speed neutrons and protons. However, numerous fundamental questions are unanswered, for example whether a single proton impact can cause Li atom sputtering, and what is the electron excitation energy profile after a collision particularly for extremely high energy projectiles. Herein, we use a real-time dependent density functional method to study these questions for proton energies in the range of 30 eV to 1 MeV...
March 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28303660/brazilin-inhibits-prostatic-acidic-phosphatase-fibrillogenesis-and-reduces-its-cytotoxicity
#17
Ming Li, Xiaoyan Dong, Yang Liu, Yan Sun
The 39-amino acid peptide fragment derived from prostatic acidic phosphatase (PAP), PAP248-286, is secreted in large amount into human semen and form amyloid fibrils. The fibrils can capture HIV virions and increase the attachment of virions to target cells, so they are called semen-derived enhancer of virus infection (SEVI). Therefore, it is of significance to inhibit the formation of PAP248-286 amyloid fibrils. Herein, we have demonstrated that brazilin could effectively inhibit PAP248-286 aggregation. The inhibition effect increased with increasing brazilin concentration...
March 16, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28303591/-31-p-magnetization-transfer-magnetic-resonance-spectroscopy-assessing-the-activation-induced-change-in-cerebral-atp-metabolic-rates-at-3-t
#18
Chen Chen, Mary C Stephenson, Andrew Peters, Peter G Morris, Susan T Francis, Penny A Gowland
PURPOSE: In vivo (31) P magnetic resonance spectroscopy (MRS) magnetization transfer (MT) provides a direct measure of neuronal activity at the metabolic level. This work aims to use functional (31) P MRS-MT to investigate the change in cerebral adenosine triphosphate (ATP) metabolic rates in healthy adults upon repeated visual stimuli. METHODS: A magnetization saturation transfer sequence with narrowband selective saturation of γ-ATP was developed for (31) P MT experiments at 3 T...
March 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28303045/dielectric-properties-optimum-formulation-and-microwave-baking-conditions-of-chickpea-cakes
#19
Yaşar Özlem Alifakı, Özge Şakıyan
The aim of this study was to correlate dielectric properties with quality parameters, and to optimize cake formulation and baking conditions by response surface methodology. Weight loss, color, specific volume, hardness and porosity were evaluated. The samples with different DATEM (0.4, 0.8 and 1.2%) and chickpea flour concentrations (30, 40 and 50%) were baked in microwave oven at different power (300, 350, 400 W) and baking times (2.50, 3.0, 3.50 min). It was found that microwave power showed significant effect on color, while baking time showed effect on weight loss, porosity, hardness, specific volume and dielectric properties...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28302986/sers-measurement-of-cysteamine-molecules-stretched-by-the-electromagnetophoretic-force
#20
Shin Wakiyama, Hitoshi Watarai
The role of an external force on chemical equilibria is an important subject in mechanobiochemistry. The effect of an electromagnetophoretic force for the stretching of cysteamine molecules was examined by using SERS spectrometry. Polystyrene particles modified with cysteamine were bound to silver nanoparticles adsorbed on the wall of a silica capillary cell. Under a constant magnetic field, when an electric current was applied to the conductive medium in the capillary, the shift of SERS bands and the increase of the trans/gauche ratio of cysteamine were observed, suggesting a molecular conformation change of cysteamine due to the stretching force...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
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