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https://www.readbyqxmd.com/read/29332049/free-heme-and-amyloid-%C3%AE-a-fatal-liaison-in-alzheimer-s-disease
#1
Elisabeth Chiziane, Henriette Telemann, Martin Krueger, Juliane Adler, Jürgen Arnhold, A Alia, Jörg Flemmig
While the etiology of Alzheimer's disease (AD) is still unknown, an increased formation of amyloid-β (Aβ) peptide and oxidative processes are major pathological mechanism of the disease. The interaction of Aβ with free heme leads to the formation of peroxidase-active Aβ-heme complexes. However, enzyme-kinetic data and systematic mutational studies are still missing. These aspects were addressed in this study to evaluate the role of Aβ-heme complexes in AD. The enzyme-kinetic measurements showed peroxidase-specific pH- and H2O2-dependencies...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29331830/fetal-development-of-the-poeppig-s-woolly-monkey-lagothrix-poeppigii
#2
Rafael Dos Santos de Andrade, Frederico Ozanan Barros Monteiro, Hani Rocha El Bizri, Wilter Ricardo Russiano Vicente, Diva Anelie de Araujo Guimarães, Pedro Mayor
The intrauterine development is an evolutionary strategy that prepares the neonate for extra-uterine life, thus providing important information on the life history of species. In this study, we described the external and internal morphology of 25 fetuses of Poeppig's woolly monkeys (Lagothrix poeppigii) by taking advantage of a 10-year participatory collection of biological samples originated from animals hunted for subsistence purposes in the Peruvian Amazon. Logistic regressions estimated the probability of occurrence of each external morphological characteristic in relation to the crown-rump length (CRL)...
December 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/29331811/volatile-organic-compounds-vocs-removal-in-non-thermal-plasma-double-dielectric-barrier-discharge-reactor
#3
Muhammad Farooq Mustafa, Xindi Fu, Yanjun Liu, Yawar Abbas, Hongtao Wang, Wenjing Lu
Non-thermal plasma (NTP) an emerging technology to treat volatile organic compounds (VOCs) present in unhygienic point source air streams. In present study, double dielectric barrier discharge (DDBD) reactors were used for the first time to evaluate the removal efficiency of VOCs mixture of different nature at constant experimental conditions (input power 16-65.8 W, VOCs mixture feeding rate 1-6 L/min, 100-101 ppm inlet concentration of individual VOC). Reactor A and B with discharge gap at 6 mm and 3 mm respectively, were used in current study...
January 9, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29331715/toxicokinetics-of-zn-and-cd-in-the-earthworm-eisenia-andrei-exposed-to-metal-contaminated-soils-under-different-combinations-of-air-temperature-and-soil-moisture-content
#4
M Nazaret González-Alcaraz, Susana Loureiro, Cornelis A M van Gestel
This study evaluated how different combinations of air temperature (20 °C and 25 °C) and soil moisture content (50% and 30% of the soil water holding capacity, WHC), reflecting realistic climate change scenarios, affect the bioaccumulation kinetics of Zn and Cd in the earthworm Eisenia andrei. Earthworms were exposed for 21 d to two metal-contaminated soils (uptake phase), followed by 21 d incubation in non-contaminated soil (elimination phase). Body Zn and Cd concentrations were checked in time and metal uptake (k1) and elimination (k2) rate constants determined; metal bioaccumulation factor (BAF) was calculated as k1/k2...
January 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29331560/the-effects-of-sediment-transport-on-temporal-variation-in-radiocesium-concentrations-in-very-shallow-water-off-the-southern-coast-of-fukushima-japan
#5
Akira Matsumoto, Hiroshi Myouse, Hisayuki Arakawa, Ken Higuchi, Naoto Hirakawa, Yoshiaki Morioka, Takuji Mizuno
We studied the very shallow coastal water off Iwaki City, Fukushima Prefecture, and investigated: (1) temporal variation in 137Cs concentrations; (2) particle-size distribution of sediments; and (3) the effect on variation by waves, component-fractionated concentration of radiocesium and mineral composition at three sampling stations (Yotsukura, Ena rocky reef and Ena sandy station). There was a decline in 137Cs concentrations in sediment samples at all sampling stations between 425 and 1173 days after the accident...
January 11, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29331138/role-of-non-equilibrium-conformations-on-driven-polymer-translocation
#6
H H Katkar, M Muthukumar
One of the major theoretical methods in understanding polymer translocation through a nanopore is the Fokker-Planck formalism based on the assumption of quasi-equilibrium of polymer conformations. The criterion for applicability of the quasi-equilibrium approximation for polymer translocation is that the average translocation time per Kuhn segment, ⟨τ⟩/NK, is longer than the relaxation time τ0 of the polymer. Toward an understanding of conditions that would satisfy this criterion, we have performed coarse-grained three dimensional Langevin dynamics and multi-particle collision dynamics simulations...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29331120/on-the-mechanical-stability-of-the-body-centered-cubic-phase-and-the-emergence-of-a-metastable-ci16-phase-in-classical-hard-sphere-solids
#7
Vadim B Warshavsky, David M Ford, Peter A Monson
The stability of the body-centered cubic (bcc) solid phase of classical hard spheres is of intrinsic interest and is also relevant to the development of perturbation theories for bcc solids of other model systems. Using canonical ensemble Monte Carlo, we simulated systems initialized in a perfect bcc lattice at various densities in the solid region. We observed that the systems rapidly evolved into one of four structures that then persisted for the duration of the simulation. Remarkably, one of these structures was identified as cI16, a cubic crystalline structure with 16 particles in the unit cell, which has recently been observed experimentally in lithium and sodium solids at high pressures...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29330239/one-year-of-family-physicians-observations-on-working-with-medical-scribes
#8
Amelia Sattler, Tracy Rydel, Cathina Nguyen, Steven Lin
PURPOSE: The immense clerical burden felt by physicians is one of the leading causes of burnout. Scribes are increasingly being used to help alleviate this burden, yet few published studies investigate how scribes affect physicians' daily work, attitudes and behaviors, and relationships with patients and the workplace. METHODS: Using a longitudinal observational design, data were collected, over 1 year, from 4 physicians working with 2 scribes at a single academic family medicine practice...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330219/a-study-on-pharmacokinetics-of-bosentan-with-systems-modeling-part-2-prospectively-predicting-systemic-and-liver-exposure-in-healthy-subjects
#9
Rui Li, Emi Kimoto, Mark Niosi, David A Tess, Jian Lin, Larry M Tremaine, Li Di
Predicting human pharmacokinetics of novel compounds is a critical step in drug discovery and clinical study design, but continues to be a challenging task for hepatic transporter substrates, particularly in predicting their liver exposures. In this study, using bosentan as an example, we have prospectively predicted systemic exposure and (pseudo) steady state unbound liver-to-unbound plasma ratio (Kpuu) in healthy subjects using (1) a mechanistic approach solely based on in vitro hepatocyte assays, and (2) an approach based on hepatic process rates from monkey in vivo data but Michaelis-Menten constants from in vitro data...
January 12, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29328708/liquid-gas-transitions-in-steady-heat-conduction
#10
Naoko Nakagawa, Shin-Ichi Sasa
We study liquid-gas transitions of heat conduction systems in contact with two heat baths under constant pressure in the linear response regime. On the basis of local equilibrium thermodynamics, we propose an equality with a global temperature, which determines the volume near the equilibrium liquid-gas transition. We find that the formation of the liquid-gas interface is accompanied by a discontinuous change in the volume when increasing the mean temperature of the baths. A supercooled gas near the interface is observed as a stable steady state...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29328210/nonlinear-absorption-and-temperature-dependent-fluorescence-of-perovskite-fapbbr3-nanocrystal
#11
Lan Yang, Ke Wei, Zhongjie Xu, Feiming Li, Runze Chen, Xin Zheng, Xiangai Cheng, Tian Jiang
Recent progress in solar cell and light-emitting devices makes halide perovskite a research hot spot in optics. In this Letter, the nonlinear absorption and fluorescence properties of FAPbBr3 nanocrystal, one typical organometallic halide perovskite, have been investigated via Z-scan measurements and a density-dependent photoluminescence (PL) spectrum. The FAPbBr3 nanocrystal exhibits nonlinear absorption under the excitation of 800 nm, whose photon energy is below the bandgap of FAPbBr3. The significant absorption is experimentally confirmed to be induced by two-photon absorption (TPA), and the TPA coefficient is measured to be ∼0...
January 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29328058/behaviour-of-niobium-during-early-earth-s-differentiation-insights-from-its-local-structure-and-oxidation-state-in-silicate-melts-at-high-pressure
#12
Chrystele Sanloup, Benjamin Cochain, Charlotte de Grouchy, Konstantin Glazyrin, Zuzana Konopkova, Hanns-Peter Liermann, Innokenty Kantor, Raffaella Torchio, O Mathon, Tetsuo Irifune
Niobium (Nb) is one of the key trace elements used to understand Earth's formation and differentiation, and is remarkable for its deficiency relative to tantalum in terrestrial rocks compared to the building chondritic blocks. In this context, the local environment of Nb in silica-rich melts and glasses is studied by in situ X-ray absorption spectroscopy (XAS) at high pressure (P) up to 9.3 GPa and 1350 K using resistive-heating diamond-anvil cells. Nb is slightly less oxidized in the melt (intermediate valence between +4 and +5) than in the glass (+5), an effect evidenced from the shift of the Nb-edge towards lower energies...
January 12, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29328001/gamma-knife-radiosurgery-of-saccular-aneurysms-in-a-rabbit-model
#13
Mark D Meadowcroft, Timothy K Cooper, Sebastian Rupprecht, Thaddeus C Wright, Elizabeth E Neely, Michele Ferenci, Weimin Kang, Qing X Yang, Robert E Harbaugh, James R Connor, James McInerney
OBJECTIVE Intracranial aneurysms are vascular abnormalities associated with neurological morbidity and mortality due to risk of rupture. In addition, many aneurysm treatments have associated risk profiles that can preclude the prophylactic treatment of asymptomatic lesions. Gamma Knife radiosurgery (GKRS) is a standard treatment for trigeminal neuralgia, tumors, and arteriovenous malformations. Aneurysms associated with arteriovenous malformations have been noted to resolve after treatment of the malformation...
January 12, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29327577/interplay-of-interfacial-layers-and-blend-composition-to-reduce-thermal-degradation-of-polymer-solar-cells-at-high-temperature
#14
Sadok Ben Dkhil, Martin Pfannmöller, Rasmus R Schroeder, Riva Alkarsifi, Meriem Gaceur, Wolfgang Köntges, Hamed Heidari, Sara Bals, Olivier Margeat, Jörg Ackermann, Christine Videlot-Ackermann
The thermal stability of printed polymer solar cells at elevated temperatures needs to be improved to achieve high-throughput fabrication including annealing steps as well as long-term stability. During device processing, thermal annealing impact both the organic photoactive layer and the two interfacial layers making detailed studies of degradation mechanism delicate. A recently identified thermally stable PTB7:PC70BM blend as photoactive layer in combination with PEDOT:PSS as hole extraction layer is used here to focus on the impact of electron extraction layer (EEL) on the thermal stability of solar cells...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29327454/ultrafast-all-optical-switching-of-germanium-based-flexible-metaphotonic-devices
#15
Wen Xiang Lim, Manukumara Manjappa, Yogesh Kumar Srivastava, Longqing Cong, Abhishek Kumar, Kevin F MacDonald, Ranjan Singh
Incorporating semiconductors as active media into metamaterials offers opportunities for a wide range of dynamically switchable/tunable, technologically relevant optical functionalities enabled by strong, resonant light-matter interactions within the semiconductor. Here, a germanium-thin-film-based flexible metaphotonic device for ultrafast optical switching of terahertz radiation is experimentally demonstrated. A resonant transmission modulation depth of 90% is achieved, with an ultrafast full recovery time of 17 ps...
January 12, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29326898/effect-of-10-weight-loss-on-simulated-taekwondo-match-performance-a-randomized-trial
#16
Leonardo de Sousa Fortes, Gustavo César de Vasconcelos, Bruna Daniella de Vasconcelos Costa, Pedro Pinheiro Paes, Emerson Franchini
The objective of the present study was to analyze the effect of 10% body mass reduction on simulated taekwondo match performance. Thirty-one male taekwondo athletes were randomly distributed in two groups: weight loss group (n= 15) - athletes in this group reduced 5% body mass per week during two successive weeks, totaling 10% body mass reduction; control group (n= 16) - athletes in this group kept their body mass constant during the 2-week period. Twenty-four hours before and after this period, athletes performed a simulated 3-round taekwondo match (6 min)...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29326037/experimental-uptake-and-depuration-of-paralytic-shellfish-toxins-in-southern-rock-lobster-jasus-edwardsii
#17
Thomas Madigan, Navreet Malhi, Jessica Tan, Catherine McLeod, Ian Stewart, Tim Harwood, Grant Mann, Alison Turnbull
In October 2012, paralytic shellfish toxins (PST) were detected in the hepatopancreas of Southern Rock Lobsters (Jasus edwardsii) collected from the east coast of Tasmania, Australia. This resulted in the first commercial closure in Australia for this species. Questions were raised on how the toxins were transferred to the lobsters, how long the toxins would persist, whether PST-contaminated hepatopancreas posed a risk to human health, and what management strategies could be applied. The aim of this study was to investigate whether PST-contaminated mussels are a potential vector enabling toxin accumulation in J...
January 8, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29324698/an-improved-coarse-alignment-algorithm-for-odometer-aided-sins-based-on-the-optimization-design-method
#18
Yonggang Zhang, Li Luo, Tao Fang, Ning Li, Guoqing Wang
An improved coarse alignment (ICA) algorithm is proposed in this paper with a focus on improving alignment accuracy of odometer-aided strapdown inertial navigation system (SINS) under variable velocity and variable acceleration condition. In the proposed algorithm, the outputs of inertial sensors and odometer in a sampling interval are linearized rather than assumed to be a constant, which improves the accuracy of the vector observations and the precision of coarse alignment. Simulation and field test results illustrate that, under variable velocity and variable acceleration condition, the proposed algorithm can obtain a better alignment performance than conventional coarse alignment method...
January 11, 2018: Sensors
https://www.readbyqxmd.com/read/29321898/sap-flow-characteristics-and-responses-to-summer-rainfall-for-pinus-tabulaeformis-and-hippophae-rhamnoides-in-the-loess-hilly-region-of-china
#19
Xu Wu, Yakun Tang, Yunming Chen, Jie Wen, Yuli Xie, Senbao Lu
As a major driving element of the structure and function of arid and semiarid ecosystems, rainfall is the essential factor limiting plant biological processes. To clarify the characteristics of transpiration and responses to summer rainfall, sap flow density (Fd) of Pinus tabulaeformis and Hippophae rhamnoides was monitored using thermal dissipation probes. In addition, midday leaf water potential (ψm) and leaf stomatal conductance (Gs) were also analyzed to determine water use strategies. The results indicated that the diurnal variation in the normalized Fd values exhibited a single-peak curve for P...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321564/spin-coupling-induced-improper-polarizations-and-latent-magnetization-in-multiferroic-bifeo3
#20
Hyun Myung Jang, Hyeon Han, Jung-Hoon Lee
Multiferroic BiFeO3 (BFO) that exhibits a gigantic off-centering polarization (OCP) is the most extensively studied material among all multiferroics. In addition to this gigantic OCP, the BFO having R3c structural symmetry is expected to exhibit a couple of parasitic improper polarizations owing to coexisting spin-polarization coupling mechanisms. However, these improper polarizations are not yet theoretically quantified. Herein, we show that there exist two distinct spin-coupling-induced improper polarizations in the R3c BFO on the basis of the Landau-Lifshitz-Ginzburg theory: ΔP LF arising from the Lifshitz gradient coupling in a cycloidal spin-density wave, and ΔP ms originating from the biquadratic magnetostrictive interaction...
January 10, 2018: Scientific Reports
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