Xuqin Liang, Qing He, Yuhua Jiao, Hui Yang, Wenbin Huang, Kangying Liu, Hongmei Lin, Linping Xu, Yuxia Hou, Yi Ding, Yue Zhang, Huimei Huang, Huaxiang Zhao
Orofacial clefts (OFCs) represent the most prevalent congenital craniofacial anomalies, significantly impacting patients' appearance, oral function, and psychological well-being. Among these, non-syndromic OFCs (NSOFCs) are the most predominant type, with the etiology attributed to a combination of genetic and environmental factors. Rare variants of key genes involved in craniofacial development-related signaling pathway are crucial in the occurrence of NSOFCs, and our recent studies have identified PTCH1, a receptor-coding gene in the Hedgehog signaling pathway, as a causative gene for NSOFCs...
February 14, 2024: Gene