keyword
MENU ▼
Read by QxMD icon Read
search

Proof of principal

keyword
https://www.readbyqxmd.com/read/29314368/spectroscopic-studies-on-photoinduced-reactions-of-the-anticancer-prodrug-trans-trans-trans-pt-n3-2-oh-2-py-2
#1
Peter J Sadler, Robbin Vernooij, Tanmaya Joshi, Michael Horbury, Bim Graham, Ekaterina Izgorodina, Vasilios Stavros, Leone Spiccia, Bayden Wood
The photodecomposition mechanism of trans,trans,trans-[Pt(N3)2(OH)2(py)2] (1, py = pyridine), an anticancer prodrug candidate, was probed using complementary Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), transient electronic absorption and UV-Vis spectroscopy. Data fitting using Principal Component Analysis (PCA) and multi-curve resolution alternating least squares, suggests the formation of a trans-[Pt(N3)(py)2(OH/H2O)] intermediate and trans [Pt(py)2(OH/H2O)2] as the final product upon 420 nm irradiation of 1 in water...
January 3, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29296828/gene-editing-rescue-of-a-novel-mpl-mutant-associated-with-congenital-amegakaryocytic-thrombocytopenia
#2
Cédric Cleyrat, Romain Girard, Eun H Choi, Éric Jeziorski, Thierry Lavabre-Bertrand, Sylvie Hermouet, Serge Carillo, Bridget S Wilson
Thrombopoietin (Tpo) and its receptor (Mpl) are the principal regulators of early and late thrombopoiesis and hematopoietic stem cell maintenance. Mutations in MPL can drastically impair its function and be a contributing factor in multiple hematologic malignancies, including congenital amegakaryocytic thrombocytopenia (CAMT). CAMT is characterized by severe thrombocytopenia at birth, which progresses to bone marrow failure and pancytopenia. Here we report unique familial cases of CAMT that presented with a previously unreported MPL mutation: T814C (W272R) in the background of the activating MPL G117T (K39N or Baltimore) mutation...
September 26, 2017: Blood Advances
https://www.readbyqxmd.com/read/29247101/therapist-guided-internet-delivered-cognitive-behavioural-therapy-supplemented-with-group-exposure-sessions-for-adolescents-with-social-anxiety-disorder-a-feasibility-trial
#3
Martina Nordh, Sarah Vigerland, Lars-Göran Öst, Brjánn Ljótsson, David Mataix-Cols, Eva Serlachius, Jens Högström
OBJECTIVES: Social anxiety disorder (SAD) is one of the most common psychiatric disorders in youth, with a prevalence of about 3%-4% and increased risk of adverse long-term outcomes, such as depression. Cognitive-behavioural therapy (CBT) is considered the first-line treatment for youth with SAD, but many adolescents remain untreated due to limited accessibility to CBT. The aim of this study was to develop and evaluate the feasibility and preliminary efficacy of a therapist-guided internet-delivered CBT treatment, supplemented with clinic-based group exposure sessions (BIP SOFT)...
December 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29228356/dietary-intervention-rescues-myopathy-associated-with-neurofibromatosis-type-1
#4
Matthew A Summers, Thusitha Rupasinghe, Emily R Vasiljevski, Frances J Evesson, Kathy Mikulec, Lauren Peacock, Kate Gr Quinlan, Sandra T Cooper, Ute Roessner, David A Stevenson, David G Little, Aaron Schindeler
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder with complex symptomology. In addition to a predisposition to tumors, children with NF1 can present with reduced muscle mass, global muscle weakness, and impaired motor skills, which can have a significant impact on quality of life. Genetic mouse models have shown a lipid storage disease phenotype may underlie muscle weakness in NF1. Herein we confirm that biopsy specimens from six individuals with NF1 similarly manifest features of a lipid storage myopathy, with marked accumulation of intramyocellular lipid, fibrosis, and mononuclear cell infiltrates...
December 8, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29175497/spatiotemporal-characterization-of-breathing-induced-b0-field-fluctuations-in-the-cervical-spinal-cord-at-7t
#5
S Johanna Vannesjo, Karla L Miller, Stuart Clare, Irene Tracey
Magnetic resonance imaging and spectroscopy of the spinal cord stand to benefit greatly from the increased signal-to-noise ratio of ultra-high field. However, ultra-high field also poses considerable technical challenges, especially related to static and dynamic B0 fields. Breathing causes the field to fluctuate with the respiratory cycle, giving rise to artifacts such as ghosting and apparent motion in images. We here investigated the spatial and temporal characteristics of breathing-induced B0 fields in the cervical spinal cord at 7 T...
November 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/29155621/science-to-practice-enhancing-photothermal-ablation-of-colorectal-liver-metastases-with-targeted-hybrid-nanoparticles
#6
Xiaoming Yang
Image-guided percutaneous thermal ablation has been one of the principal tools in management of unresectable liver malignancies, including colorectal liver metastases (CRLM) ( 1 ). Currently, however, this technique is suitable mainly for tumors less than 4-5 cm in diameter and also results in incomplete ablation at tumor margins ( 2 ). To solve these problems, efforts have been made to combine thermal ablation with other treatment options, such as systemic and intra-arterial administration of therapeutics ( 3 - 5 )...
December 2017: Radiology
https://www.readbyqxmd.com/read/29135026/sensory-and-flavor-characteristics-of-tomato-juice-from-garden-gem-and-roma-tomatoes-with-comparison-to-commercial-tomato-juice
#7
Yaozhou Zhu, Charles A Sims, Harry J Klee, Paul J Sarnoski
The objective of this study was to characterize the flavor of a premium Florida tomato variety that has significant potential for producing a high quality processed juice product. A high-quality Florida plum tomato variety (Garden Gem), and a typical grocery-store plum tomato variety (Roma) were thermally processed into tomato juices without any additives. The 2 pilot products and a popular commercially available tomato juice (low sodium with sugar and flavor added) were compared using sensory evaluation and instrumental analysis...
November 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29130686/thioamide-substitution-selectively-modulates-proteolysis-and-receptor-activity-of-therapeutic-peptide-hormones
#8
Xing Chen, Elizabeth G Mietlicki-Baase, Taylor M Barrett, Lauren E McGrath, Kieran Koch-Laskowski, John J Ferrie, Matthew R Hayes, E James Petersson
Peptide hormones are attractive as injectable therapeutics and imaging agents, but they often require extensive modification by mutagenesis and/or chemical synthesis to prevent rapid in vivo degradation. Alternatively, the single-atom, O-to-S modification of peptide backbone thioamidation has the potential to selectively perturb interactions with proteases while preserving interactions with other proteins, such as target receptors. Here, we use the validated diabetes therapeutic, glucagon-like peptide-1 (GLP-1), and the target of clinical investigation, gastric inhibitory polypeptide (GIP), as proof-of-principle peptides to demonstrate the value of thioamide substitution...
November 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29107219/adult-fly-age-estimations-using-cuticular-hydrocarbons-and-artificial-neural-networks-in-forensically-important-calliphoridae-species
#9
Hannah E Moore, John B Butcher, Charles R Day, Falko P Drijfhout
Blowflies (Diptera: Calliphoridae) are forensically important as they are known to be one of the first to colonise human remains. The larval stage is typically used to assist a forensic entomologists with adult flies rarely used as they are difficult to age because they remain morphologically similar once they have gone through the initial transformation upon hatching. However, being able to age them is of interest and importance within the field. This study examined the cuticular hydrocarbons (CHC) of Diptera: Calliphoridae species Lucilia sericata, Calliphora vicina and Calliphora vomitoria...
October 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29064247/in-situ-stimulation-of-thiocyanate-biodegradation-through-phosphate-amendment-in-gold-mine-tailings-water
#10
Mathew P Watts, Han M Gan, Lee Y Peng, Kim-Anh Lê Cao, John W Moreau
Thiocyanate (SCN(-)) is a contaminant requiring remediation in gold mine tailings and wastewaters globally. Seepage of SCN(-)-contaminated waters into aquifers can occur from unlined or structurally compromised mine tailings storage facilities. A wide variety of microorganisms are known to be capable of biodegrading SCN(-); however, little is known regarding the potential of native microbes for in situ SCN(-) biodegradation, a remediation option that is less costly than engineered approaches. Here we experimentally characterize the principal biogeochemical barrier to SCN(-) biodegradation for an autotrophic microbial consortium enriched from mine tailings, to arrive at an environmentally realistic assessment of in situ SCN(-) biodegradation potential...
November 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29060471/kernel-based-adaptive-learning-improves-accuracy-of-glucose-predictive-modelling-in-type-1-diabetes-a-proof-of-concept-study
#11
Eleni I Georga, Jose C Principe, Evangelos C Rizos, Dimitrios I Fotiadis
This study aims at demonstrating the need for nonlinear recursive models to the identification and prediction of the dynamic glucose system in type 1 diabetes. Nonlinear regression is performed in a reproducing kernel Hilbert space, by the Approximate Linear Dependency Kernel Recursive Least Squares (KRLS-ALD) algorithm, such that a sparse model structure is accomplished. The method is evaluated on seven people with type 1 diabetes in free-living conditions, where a change in glycaemic dynamics is forced by increasing the level of physical activity in the middle of the observational period...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28975197/association-of-multiorgan-computed-tomographic-phenomap-with-adverse-cardiovascular-health-outcomes-the-framingham-heart-study
#12
Ravi V Shah, Ashish S Yeri, Venkatesh L Murthy, Joe M Massaro, Ralph D'Agostino, Jane E Freedman, Michelle T Long, Caroline S Fox, Saumya Das, Emelia J Benjamin, Ramachandran S Vasan, Christopher J O'Donnell, Udo Hoffmann
Importance: Increased ability to quantify anatomical phenotypes across multiple organs provides the opportunity to assess their cumulative ability to identify individuals at greatest susceptibility for adverse outcomes. Objective: To apply unsupervised machine learning to define the distribution and prognostic importance of computed tomography-based multiorgan phenotypes associated with adverse health outcomes. Design, Setting, and Participants: This asymptomatic community-based cohort study included 2924 Framingham Heart Study participants between July 2002 and April 2005 undergoing computed tomographic imaging of the chest and abdomen...
November 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28969656/inadequate-programming-insufficient-communication-and-non-compliance-with-the-basic-principles-of-maternal-death-audits-in-health-districts-in-burkina-faso-a-qualitative-study
#13
Boukaré Congo, Djénéba Sanon, Tieba Millogo, Charlemagne Marie Ouedraogo, Wambi Maurice E Yaméogo, Ziemlé Clement Meda, Seni Kouanda
BACKGROUND: Implementation of quality maternal death audits requires good programming, good communication and compliance with core principles. Studies on compliance with core principles in the conduct of maternal death audits (MDAs) exist but were conducted in urban areas, at the 2nd or 3rd level of the healthcare system, in experimental situations, or in a context of skills-building projects or technical platforms with an emphasis on the review of "near miss". This study aims to fill the gap of evidence on the implementation of MDAs in rural settings, at the first level of care and in the routine care situation in Burkina Faso...
September 29, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28900188/decoding-finger-movement-in-humans-using-synergy-of-eeg-cortical-current-signals
#14
Natsue Yoshimura, Hayato Tsuda, Toshihiro Kawase, Hiroyuki Kambara, Yasuharu Koike
The synchronized activity of neuronal populations across multiple distant brain areas may reflect coordinated interactions of large-scale brain networks. Currently, there is no established method to investigate the temporal transitions between these large-scale networks that would allow, for example, to decode finger movements. Here we applied a matrix factorization method employing principal component and temporal independent component analyses to identify brain activity synchronizations. In accordance with previous studies investigating "muscle synergies", we refer to this activity as "brain activity synergy"...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892681/optimization-of-the-yield-of-dark-microaerobic-production-of-hydrogen-from-lactate-by-rhodopseudomonas-palustris
#15
Carolina Zampol Lazaro, Zeynep Yilmazer Hitit, Patrick C Hallenbeck
Hydrogen yields of dark fermentation are limited due to the need to also produce reduced side products, and photofermentation, an alternative, is limited by the need for light. A relatively new strategy, dark microaerobic fermentation, could potentially overcome both these constraints. Here, application of this strategy demonstrated for the first time significant hydrogen production from lactate by a single organism in the dark. Response surface methodology (RSM) was used to optimize substrate and oxygen concentration as well as inoculum using both (1) regular batch and (2) O2 fed batch cultures...
December 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28878778/multivariate-analysis-as-a-support-for-diagnostic-flowcharts-in-allergic-bronchopulmonary-aspergillosis-a-proof-of-concept-study
#16
Joana Vitte, Stéphane Ranque, Ania Carsin, Carine Gomez, Thomas Romain, Carole Cassagne, Marion Gouitaa, Mélisande Baravalle-Einaudi, Nathalie Stremler-Le Bel, Martine Reynaud-Gaubert, Jean-Christophe Dubus, Jean-Louis Mège, Jean Gaudart
Molecular-based allergy diagnosis yields multiple biomarker datasets. The classical diagnostic score for allergic bronchopulmonary aspergillosis (ABPA), a severe disease usually occurring in asthmatic patients and people with cystic fibrosis, comprises succinct immunological criteria formulated in 1977: total IgE, anti-Aspergillus fumigatus (Af) IgE, anti-Af "precipitins," and anti-Af IgG. Progress achieved over the last four decades led to multiple IgE and IgG(4) Af biomarkers available with quantitative, standardized, molecular-level reports...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28861130/using-expectancy-value-theory-as-a-framework-to-reduce-student-resistance-to-active-learning-a-proof-of-concept
#17
Katelyn M Cooper, Michael Ashley, Sara E Brownell
There has been a national movement to transition college science courses from passive lectures to active learning environments. Active learning has been shown to be a more effective way for students to learn, yet there is concern that some students are resistant to active learning approaches. Although there is much discussion about student resistance to active learning, few studies have explored this topic. Furthermore, a limited number of studies have applied theoretical frameworks to student engagement in active learning...
2017: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28841588/thrombosis-in-adult-patients-with-acute-leukemia
#18
Maria Ilaria Del Principe, Domenico Del Principe, Adriano Venditti
PURPOSE OF REVIEW: Recent studies indicate that the risk of thrombosis in hematologic patients may be similar or even higher than that found in patients with solid tumors. However, available information about pathogenesis and incidence of thrombosis in acute leukemia is limited. This review focuses on mechanisms underlying thrombosis in acute leukemia and discusses recent literature data. RECENT FINDINGS: In the last few years, proofs have been provided that leukemic cells release free prothrombotic products, such as micro-vesicles, tissue factors, circulating free DNA and RNA...
November 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28815143/analyzing-electronic-medical-records-to-predict-risk-of-dit-death-intubation-or-transfer-to-icu-in-pediatric-respiratory-failure-or-related-conditions
#19
Teeradache Viangteeravat, Oguz Akbilgic, Robert Lowell Davis
Large volumes of data are generated in hospital settings, including clinical and physiological data generated during the course of patient care. Our goal, as proof of concept, was to identify early clinical factors or traits useful for predicting the outcome, of death, intubation, or transfer to ICU, for children with pediatric respiratory failure. We implemented both supervised and unsupervised methods to extend our understanding on statistical relationships in clinical and physiological data. As a supervised learning method, we use binary logistic regression to predict the risk of developing DIT outcome...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28782187/sensitive-three-dimensional-ultrasound-assessment-of-carotid-atherosclerosis-by-weighted-average-of-local-vessel-wall-and-plaque-thickness-change
#20
Jieyu Cheng, Eranga Ukwatta, Shadi Shavakh, Tommy W S Chow, Grace Parraga, J David Spence, Bernard Chiu
PURPOSE: Vitamin B deficiency has been identified as a risk factor for vascular events. However, the reduction of vascular events was not shown in large randomized controlled trials evaluating B-Vitamin therapy. There is an important requirement to develop sensitive biomarkers to be used as efficacy targets for B-Vitamin therapy as well as other dietary treatments and lifestyle regimes that are being developed. Carotid vessel-wall-plus-plaque thickness change (VWT-Change) measured from 3D ultrasound has been shown to be sensitive to atorvastatin therapies in previous studies...
October 2017: Medical Physics
keyword
keyword
57910
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"