Read by QxMD icon Read

Proof of principal

Peter M Irving, Tariq Iqbal, Chuka Nwokolo, Sreedhar Subramanian, Stuart Bloom, Neeraj Prasad, Ailsa Hart, Charles Murray, James O Lindsay, Adam Taylor, Rachel Barron, Stephen Wright
Background: Cannabidiol (CBD) exhibits anti-inflammatory properties that could improve disease activity in inflammatory bowel disease. This proof-of-concept study assessed efficacy, safety and tolerability of CBD-rich botanical extract in ulcerative colitis (UC) patients. Methods: Patients aged 18 years or older, with left-sided or extensive UC, Mayo scores of 4-10 (endoscopy scores ≥1), and on stable 5-aminosalicylic acid dosing, were randomized to 10-weeks' CBD-rich botanical extract or placebo capsules...
March 10, 2018: Inflammatory Bowel Diseases
S A Moiseev, K I Gerasimov, R R Latypov, N S Perminov, K V Petrovnin, O N Sherstyukov
In this paper we experimentally demonstrated a broadband scheme of the multiresonator quantum memory-interface. The microwave photonic scheme consists of the system of mini-resonators strongly interacting with a common broadband resonator coupled with the external waveguide. We have implemented the impedance matched quantum storage in this scheme via controllable tuning of the mini-resonator frequencies and coupling of the common resonator with the external waveguide. Proof-of-principal experiment has been demonstrated for broadband microwave pulses when the quantum efficiency of 16...
March 5, 2018: Scientific Reports
Julius Philipp Paul Zauleck, Martin Thomas Peschel, Florian Rott, Sebastian Thallmair, Regina de Vivie-Riedle
The inclusion of solvent effects in the theoretical analysis of molecular processes becomes increasingly important. Currently, it is not feasible to directly include the solvent on the quantum level. We use an Ehrenfest approach to study the coupled time evolution of quantum dynamically treated solutes and classical solvents system. The classical dynamics of the solvent is coupled to the wavepacket dynamics of the solute and rotational and translational degrees of freedom of the solute are included classically...
March 2, 2018: Journal of Physical Chemistry. A
Lukas Hrachowina, Guillem Domènech-Gil, Antonio Pardo, Michael S Seifner, Isabel Gracia, Carles Cané, Albert Romano-Rodriguez, Sven Barth
A new method for the site-selective synthesis of nanowires has been developed to enable material growth with defined morphology and at the same time different composition on the same chip surface. The chemical vapour deposition approach for the growth of these nanowire-based resistive devices using micromembranes can be easily modified and represents a simple, adjustable fabrication process for the direct integration of nanowire meshes in multifunctional devices. This proof-of-concept study includes the deposition of SnO2, WO3 and Ge nanowires on the same chip...
February 27, 2018: ACS Sensors
Anselm Jünemann, Bettina Hohberger, Jürgen Rech, Ahmed Sheriff, Qin Fu, Ursula Schlötzer-Schrehardt, Reinhard Edmund Voll, Sabine Bartel, Hubert Kalbacher, Johan Hoebeke, Robert Rejdak, Folkert Horn, Gerd Wallukat, Rudolf Kunze, Martin Herrmann
Glaucoma is a frequent ocular disease that may lead to blindness. Primary open-angle glaucoma (POAG) and ocular hypertension (OHT) are common diseases with increased intraocular pressure (IOP), which are mainly responsible for these disorders. Their pathogenesis is widely unknown. We screened the sera of patients with POAG and OHT for the prevalence of autoantibodies (AAb) against G protein-coupled receptors (GPCRs) in comparison to controls. Employing frequency modulation of spontaneously contracting neonatal rat cardiomyocytes in vitro , agonistic GPCR AAb were to be detected in roughly 75% of the patients with POAG and OHT, however, not in controls...
2018: Frontiers in Immunology
Gwyneth B Ross, Brittany Dowling, Nikolaus F Troje, Steven L Fischer, Ryan B Graham
INTRODUCTION: Movement screens are frequently used to identify abnormal movement patterns that may increase risk of injury or hinder performance. Abnormal patterns are often detected visually based on the observations of a coach or clinician. Quantitative, or data-driven methods can increase objectivity, remove issues related to inter-rater reliability and offer the potential to detect new and important features that may not be observable by the human eye. Applying principal components analysis (PCA) to whole-body motion data may provide an objective data-driven method to identify unique and statistically important movement patterns, an important first step to objectively characterize optimal patterns or identify abnormalities...
February 5, 2018: Medicine and Science in Sports and Exercise
Hi Gyu Moon, Youngmo Jung, Dukwoo Jun, Ji Hyun Park, Young Wook Chang, Hyung-Ho Park, Chong-Yun Kang, Chulki Kim, Richard B Kaner
Hollow-structured nanomaterials are presented as an outstanding sensing platform because of their unique combination of high porosity in both the micro- and nanoscale, their biocompatibility, and flexible template applicability. Herein, we introduce a bacterial skeleton method allowing for cost-effective fabrication with nanoscale precision. As a proof-of-concept, we fabricated a hollow SnO2 hemipill network (HSHN) and a hollow Pt-functionalized SnO2 hemipill network (HPN). A superior detecting capability of HPN toward acetone, a diabetes biomarker, was demonstrated at low concentration (200 ppb) under high humidity (RH 80%)...
February 7, 2018: ACS Sensors
Pankaj Singh, Gyana Ranjan Sahoo, Asima Pradhan
A spatio-temporal map of human cervical tissue is obtained from time-resolved fluorescence images with the dynamic contrast enhanced through Principal Component Analysis (PCA) for clear demarcation of regions of normal and pre-cancerous conditions. Changes in the properties of fluorescence in different environments are captured through fluorescence lifetime maps in the human cervical tissue sample. The correlation embodied in the 2nd PC representing sectorial information free of background of the 1st PC, segregates fluorescence activities, as illustrated in the PC maps...
February 7, 2018: Journal of Biophotonics
George A Bray, Leanne M Redman, Lilian de Jonge, Jennifer Rood, Elizabeth F Sutton, Steven R Smith
OBJECTIVE: Overfeeding is a strategy for evaluating the effects of excess energy intake. In this secondary analysis we tested the possibility that different levels of dietary protein might differentially modify the response of fatty acyl-carnitines to overfeeding. METHODS: Twenty-three healthy adult men and women were overfed by 40% for 8 weeks while in-patients with diets containing 5% (LPD), 15% (NPD) or 25% (HPD) protein. Plasma fatty acyl-carnitines were measured by gas chromatography/mass spectrometry (GC/MS) at baseline and after 8 weeks of overfeeding...
January 24, 2018: Metabolism: Clinical and Experimental
A Mesut Erzurumluoglu, Denis Baird, Tom G Richardson, Nicholas J Timpson, Santiago Rodriguez
Y-chromosomal (Y-DNA) haplogroups are more widely used in population genetics than in genetic epidemiology, although associations between Y-DNA haplogroups and several traits, including cardiometabolic traits, have been reported. In apparently homogeneous populations defined by principal component analyses, there is still Y-DNA haplogroup variation which will result from population history. Therefore, hidden stratification and/or differential phenotypic effects by Y-DNA haplogroups could exist. To test this, we hypothesised that stratifying individuals according to their Y-DNA haplogroups before testing for associations between autosomal single nucleotide polymorphisms (SNPs) and phenotypes will yield difference in association...
January 22, 2018: Genes
Peter J Sadler, Robbin Vernooij, Tanmaya Joshi, Michael Horbury, Bim Graham, Ekaterina Izgorodina, Vasilios Stavros, Leone Spiccia, Bayden Wood
The photodecomposition mechanism of trans,trans,trans-[Pt(N3)2(OH)2(py)2] (1, py = pyridine), an anticancer prodrug candidate, was probed using complementary Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), transient electronic absorption and UV-Vis spectroscopy. Data fitting using Principal Component Analysis (PCA) and multi-curve resolution alternating least squares, suggests the formation of a trans-[Pt(N3)(py)2(OH/H2O)] intermediate and trans [Pt(py)2(OH/H2O)2] as the final product upon 420 nm irradiation of 1 in water...
January 3, 2018: Chemistry: a European Journal
Cédric Cleyrat, Romain Girard, Eun H Choi, Éric Jeziorski, Thierry Lavabre-Bertrand, Sylvie Hermouet, Serge Carillo, Bridget S Wilson
Thrombopoietin (Tpo) and its receptor (Mpl) are the principal regulators of early and late thrombopoiesis and hematopoietic stem cell maintenance. Mutations in MPL can drastically impair its function and be a contributing factor in multiple hematologic malignancies, including congenital amegakaryocytic thrombocytopenia (CAMT). CAMT is characterized by severe thrombocytopenia at birth, which progresses to bone marrow failure and pancytopenia. Here we report unique familial cases of CAMT that presented with a previously unreported MPL mutation: T814C (W272R) in the background of the activating MPL G117T (K39N or Baltimore) mutation...
September 26, 2017: Blood Advances
Martina Nordh, Sarah Vigerland, Lars-Göran Öst, Brjánn Ljótsson, David Mataix-Cols, Eva Serlachius, Jens Högström
OBJECTIVES: Social anxiety disorder (SAD) is one of the most common psychiatric disorders in youth, with a prevalence of about 3%-4% and increased risk of adverse long-term outcomes, such as depression. Cognitive-behavioural therapy (CBT) is considered the first-line treatment for youth with SAD, but many adolescents remain untreated due to limited accessibility to CBT. The aim of this study was to develop and evaluate the feasibility and preliminary efficacy of a therapist-guided internet-delivered CBT treatment, supplemented with clinic-based group exposure sessions (BIP SOFT)...
December 14, 2017: BMJ Open
Matthew A Summers, Thusitha Rupasinghe, Emily R Vasiljevski, Frances J Evesson, Kathy Mikulec, Lauren Peacock, Kate G R Quinlan, Sandra T Cooper, Ute Roessner, David A Stevenson, David G Little, Aaron Schindeler
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder with complex symptomology. In addition to a predisposition to tumors, children with NF1 can present with reduced muscle mass, global muscle weakness, and impaired motor skills, which can have a significant impact on quality of life. Genetic mouse models have shown a lipid storage disease phenotype may underlie muscle weakness in NF1. Herein we confirm that biopsy specimens from six individuals with NF1 similarly manifest features of a lipid storage myopathy, with marked accumulation of intramyocellular lipid, fibrosis, and mononuclear cell infiltrates...
February 15, 2018: Human Molecular Genetics
S Johanna Vannesjo, Karla L Miller, Stuart Clare, Irene Tracey
Magnetic resonance imaging and spectroscopy of the spinal cord stand to benefit greatly from the increased signal-to-noise ratio of ultra-high field. However, ultra-high field also poses considerable technical challenges, especially related to static and dynamic B0 fields. Breathing causes the field to fluctuate with the respiratory cycle, giving rise to artifacts such as ghosting and apparent motion in images. We here investigated the spatial and temporal characteristics of breathing-induced B0 fields in the cervical spinal cord at 7T...
November 22, 2017: NeuroImage
Xiaoming Yang
Image-guided percutaneous thermal ablation has been one of the principal tools in management of unresectable liver malignancies, including colorectal liver metastases (CRLM) ( 1 ). Currently, however, this technique is suitable mainly for tumors less than 4-5 cm in diameter and also results in incomplete ablation at tumor margins ( 2 ). To solve these problems, efforts have been made to combine thermal ablation with other treatment options, such as systemic and intra-arterial administration of therapeutics ( 3 - 5 )...
December 2017: Radiology
Yaozhou Zhu, Charles A Sims, Harry J Klee, Paul J Sarnoski
The objective of this study was to characterize the flavor of a premium Florida tomato variety that has significant potential for producing a high quality processed juice product. A high-quality Florida plum tomato variety (Garden Gem), and a typical grocery-store plum tomato variety (Roma) were thermally processed into tomato juices without any additives. The 2 pilot products and a popular commercially available tomato juice (low sodium with sugar and flavor added) were compared using sensory evaluation and instrumental analysis...
November 14, 2017: Journal of Food Science
Xing Chen, Elizabeth G Mietlicki-Baase, Taylor M Barrett, Lauren E McGrath, Kieran Koch-Laskowski, John J Ferrie, Matthew R Hayes, E James Petersson
Peptide hormones are attractive as injectable therapeutics and imaging agents, but they often require extensive modification by mutagenesis and/or chemical synthesis to prevent rapid in vivo degradation. Alternatively, the single-atom, O-to-S modification of peptide backbone thioamidation has the potential to selectively perturb interactions with proteases while preserving interactions with other proteins, such as target receptors. Here, we use the validated diabetes therapeutic, glucagon-like peptide-1 (GLP-1), and the target of clinical investigation, gastric inhibitory polypeptide (GIP), as proof-of-principle peptides to demonstrate the value of thioamide substitution...
November 22, 2017: Journal of the American Chemical Society
Hannah E Moore, John B Butcher, Charles R Day, Falko P Drijfhout
Blowflies (Diptera: Calliphoridae) are forensically important as they are known to be one of the first to colonise human remains. The larval stage is typically used to assist a forensic entomologists with adult flies rarely used as they are difficult to age because they remain morphologically similar once they have gone through the initial transformation upon hatching. However, being able to age them is of interest and importance within the field. This study examined the cuticular hydrocarbons (CHC) of Diptera: Calliphoridae species Lucilia sericata, Calliphora vicina and Calliphora vomitoria...
October 8, 2017: Forensic Science International
Mathew P Watts, Han M Gan, Lee Y Peng, Kim-Anh Lê Cao, John W Moreau
Thiocyanate (SCN(-)) is a contaminant requiring remediation in gold mine tailings and wastewaters globally. Seepage of SCN(-)-contaminated waters into aquifers can occur from unlined or structurally compromised mine tailings storage facilities. A wide variety of microorganisms are known to be capable of biodegrading SCN(-); however, little is known regarding the potential of native microbes for in situ SCN(-) biodegradation, a remediation option that is less costly than engineered approaches. Here we experimentally characterize the principal biogeochemical barrier to SCN(-) biodegradation for an autotrophic microbial consortium enriched from mine tailings, to arrive at an environmentally realistic assessment of in situ SCN(-) biodegradation potential...
November 8, 2017: Environmental Science & Technology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"