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https://www.readbyqxmd.com/read/28088244/study-of-the-variability-of-scapular-inclination-and-the-glenoid-version-considerations-for-preoperative-planning-clinical-radiological-study
#1
Petr Fulin, Martin Kysilko, David Pokorny, Radek Padr, Nikola Kasprikova, Ivan Landor, Antonin Sosna
BACKGROUND: Preoperative planning with the aid of imaging methods is a principal factor in successful surgery on the shoulder. This work aims to evaluate the variability of glenoid version, spiralling twist and scapular inclination in relation to the frontal axis. Studies focusing on measuring the variability of scapular inclination in the standardised rest position are lacking in the literature. METHODS: We evaluated 104 CT scans of the shoulder. We measured the glenoid version with respect to the scapular axis at three levels...
January 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28081583/-early-results-of-adjuvant-topical-treatment-of-recurrent-osteomyelitis-with-absorbable-antibiotic-carriers
#2
Y Gramlich, G Walter, J Gils, R Hoffmann
Background Treatment of musculoskeletal infections principally consists of radical surgical debridement and systemic administration of antibiotics. Additional local antibiotic therapy is not yet generally established, and lacks evidence-based proof of efficacy. Nonetheless, there are a variety of practical approaches, as most specialised departments are unwilling to forego this option. The established polymethylmetacrylate (PMMA) carrier system has a number of practical disadvantages. This has led to the increased use of absorbable carrier systems, and those based on calcium sulphate have given particularly encouraging results...
January 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28054957/molecular-biomarkers-for-prediction-of-targeted-therapy-response-in-metastatic-breast-cancer-trick-or-treat
#3
REVIEW
Angela Toss, Marta Venturelli, Chiara Peterle, Federico Piacentini, Stefano Cascinu, Laura Cortesi
In recent years, the study of genomic alterations and protein expression involved in the pathways of breast cancer carcinogenesis has provided an increasing number of targets for drugs development in the setting of metastatic breast cancer (i.e., trastuzumab, everolimus, palbociclib, etc.) significantly improving the prognosis of this disease. These drugs target specific molecular abnormalities that confer a survival advantage to cancer cells. On these bases, emerging evidence from clinical trials provided increasing proof that the genetic landscape of any tumor may dictate its sensitivity or resistance profile to specific agents and some studies have already showed that tumors treated with therapies matched with their molecular alterations obtain higher objective response rates and longer survival...
January 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28047240/we-ab-207b-07-dose-cloud-generating-big-data-for-radiation-therapy-treatment-plan-optimization-research
#4
M M Folkerts, T Long, R J Radke, Z Tian, X Jia, M Chen, W Lu, S B Jiang
PURPOSE: To provide a tool to generate large sets of realistic virtual patient geometries and beamlet doses for treatment optimization research. This tool enables countless studies exploring the fundamental interplay between patient geometry, objective functions, weight selections, and achievable dose distributions for various algorithms and modalities. METHODS: Generating realistic virtual patient geometries requires a small set of real patient data. We developed a normalized patient shape model (PSM) which captures organ and target contours in a correspondence-preserving manner...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28009592/assessment-of-acute-trauma-exposure-response-for-fire-ems-personnel
#5
Melissa C Hoffmann
PURPOSE: The purpose of this study was to develop an instrument that measures response to acute trauma exposure for firefighter and emergency medical service (EMS) personnel. The Acute Trauma Exposure Response Scale (ATERS) was intended to assess firefighter and EMS personnel response to acute trauma exposure from analytical, emotional, and physical perspectives. METHODS: Data were analyzed on 97 firefighter and EMS personnel employed by a fire department in a mid-sized city in a western state...
2016: Journal of Applied Measurement
https://www.readbyqxmd.com/read/27958241/psychometric-properties-of-a-turkish-version-of-the-oral-health-impact-profile-14
#6
N Balci, N Alkan, C A Gurgan
OBJECTIVES: The purpose of this study was to analyze and evaluate a Turkish translation of the oral health impact profile-14 (OHIP-14) in a Turkish population to provide an objective standard for future studies. METHODS: This cross-sectional research study consisted of three independent studies. Data were collected utilizing a personal interview and a review of periodontal records. This study was performed on 1205 subjects who were visiting for routine medical check-ups...
January 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27885707/spatial-resolution-and-velocity-field-improvement-of-4d-flow-mri
#7
Fraser M Callaghan, Stuart M Grieve
PURPOSE: 4D-flow MRI obtains a time-dependent 3D velocity field; however, its use for the calculation of higher-order parameters is limited by noise. We present an algorithm for denoising 4D-flow data. THEORY AND METHODS: By integrating a velocity field and eliminating streamlines in noisy flow, depicted by high curvature, a denoised dataset may be extracted. This method, defined as the velocity field improvement (VFIT) algorithm, was validated in an analytical dataset and using in vivo data in comparison with a computation fluid dynamics (CFD) simulation...
November 24, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27872098/systematic-drug-screening-identifies-tractable-targeted-combination-therapies-in-triple-negative-breast-cancer
#8
Vikram B Wali, Casey G Langdon, Matthew A Held, James T Platt, Gauri A Patwardhan, Anton Safonov, Bilge Aktas, Lajos Pusztai, David F Stern, Christos Hatzis
Triple-negative breast cancer (TNBC) remains an aggressive disease without effective targeted therapies. In this study, we addressed this challenge by testing 128 FDA-approved or investigational drugs as either single agents or in 768 pairwise drug combinations in TNBC cell lines to identify synergistic combinations tractable to clinical translation. Medium-throughput results were scrutinized and extensively analyzed for sensitivity patterns, synergy, anticancer activity, and were validated in low-throughput experiments...
January 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/27836429/functional-and-effective-brain-connectivity-for-discrimination-between-alzheimer-s-patients-and-healthy-individuals-a-study-on-resting-state-eeg-rhythms
#9
Katarzyna J Blinowska, Franciszek Rakowski, Maciej Kaminski, Fabrizio De Vico Fallani, Claudio Del Percio, Roberta Lizio, Claudio Babiloni
OBJECTIVE: This exploratory study provided a proof of concept of a new procedure using multivariate electroencephalographic (EEG) topographic markers of cortical connectivity to discriminate normal elderly (Nold) and Alzheimer's disease (AD) individuals. METHOD: The new procedure was tested on an existing database formed by resting state eyes-closed EEG data (19 exploring electrodes of 10-20 system referenced to linked-ear reference electrodes) recorded in 42 AD patients with dementia (age: 65...
October 22, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27832353/a-proof-of-principal-study-on-the-use-of-direct-pcr-of-semen-and-spermatozoa-and-development-of-a-differential-isolation-protocol-for-use-in-cases-of-alleged-sexual-assault
#10
Shanan S Tobe, Yuvaneswari C Swaran, Lynn Dennany, Ursula Sibbing, Kristina Schulze Johann, Lindsey Welch, Marielle Vennemann
Sexual assault samples are some of the most common samples encountered in forensic analysis. These samples can require a significant time investment due to differential extraction processes. We report on the first record of successful direct amplification of semen for STR analysis. Neat seminal fluid, dilutions ranging from 1:5 to 1:160 and GEDNAP samples were successfully amplified using a direct method. A mild differential isolation technique to enrich spermatozoa was developed and successfully implemented to separate and directly amplify a mixture of semen and female epithelial cells...
January 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27770634/repair-of-bone-defects-in%C3%A2-vivo-using-tissue-engineered-hypertrophic-cartilage-grafts-produced-from-nasal-chondrocytes
#11
Katie Bardsley, Agnieska Kwarciak, Christine Freeman, Ian Brook, Paul Hatton, Aileen Crawford
The regeneration of large bone defects remains clinically challenging. The aim of our study was to use a rat model to use nasal chondrocytes to engineer a hypertrophic cartilage tissue which could be remodelled into bone in vivo by endochondral ossification. Primary adult rat nasal chondrocytes were isolated from the nasal septum, the cell numbers expanded in monolayer culture and the cells cultured in vitro on polyglycolic acid scaffolds in chondrogenic medium for culture periods of 5-10 weeks. Hypertrophic differentiation was assessed by determining the temporal expression of key marker genes and proteins involved in hypertrophic cartilage formation...
October 11, 2016: Biomaterials
https://www.readbyqxmd.com/read/27720994/non-invasive-epicutaneous-vaccine-against-respiratory-syncytial-virus-preclinical-proof-of-concept
#12
Pierre-Louis Hervé, Delphyne Descamps, Charlotte Deloizy, Véronique Dhelft, Daphné Laubreton, Edwige Bouguyon, Abdelhak Boukadiri, Catherine Dubuquoy, Thibaut Larcher, Pierre-Henri Benhamou, Jean-François Eléouët, Nicolas Bertho, Lucie Mondoulet, Sabine Riffault
To put a Respiratory Syncytial Virus (RSV) vaccine onto the market, new vaccination strategies combining scientific and technical innovations need to be explored. Such a vaccine would also need to be adapted to the vaccination of young children that are the principal victims of acute RSV infection. In the present project, we describe the development and the preclinical evaluation of an original epicutaneous RSV vaccine that combines two technologies: Viaskin® epicutaneous patches as a delivery platform and RSV N-nanorings (N) as a subunit antigen...
December 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27589689/combining-radiomic-features-with-a-mirna-classifier-may-improve-prediction-of-malignant-pathology-for-pancreatic-intraductal-papillary-mucinous-neoplasms
#13
Jennifer B Permuth, Jung Choi, Yoganand Balarunathan, Jongphil Kim, Dung-Tsa Chen, Lu Chen, Sonia Orcutt, Matthew P Doepker, Kenneth Gage, Geoffrey Zhang, Kujtim Latifi, Sarah Hoffe, Kun Jiang, Domenico Coppola, Barbara A Centeno, Anthony Magliocco, Qian Li, Jose Trevino, Nipun Merchant, Robert Gillies, Mokenge Malafa
Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cancer precursors incidentally discovered by cross-sectional imaging. Consensus guidelines for IPMN management rely on standard radiologic features to predict pathology, but they lack accuracy. Using a retrospective cohort of 38 surgically-resected, pathologically-confirmed IPMNs (20 benign; 18 malignant) with preoperative computed tomography (CT) images and matched plasma-based 'miRNA genomic classifier (MGC)' data, we determined whether quantitative 'radiomic' CT features (+/- the MGC) can more accurately predict IPMN pathology than standard radiologic features 'high-risk' or 'worrisome' for malignancy...
August 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27578400/immunization-with-electroporation-enhances-the-protective-effect-of-a-dna-vaccine-candidate-expressing-prme-antigen-against-dengue-virus-serotype-2-infection
#14
Hui Chen, Xiaoyan Zheng, Ran Wang, Na Gao, Ziyang Sheng, Dongying Fan, Kaihao Feng, Xianzheng Liao, Jing An
PURPOSE: We aimed to use the dengue virus (DV) serotype 2 as a proof of principal for testing the efficacy of a DNA vaccine candidate via in vivo electroporation in mice and rabbits prior to the development of a tetravalent vaccine. METHODS: Different dosages of DNA pVAX1-D2ME encoding DV2 prME genes were vaccinated in mice via intramuscular injection or in vivo electroporation, immune responses and protection were determined. In DNA-vaccinated rabbits via electroporation, antibody titer and protein expression were tested...
October 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27559328/identifying-objective-eeg-based-markers-of-linear-vection-in-depth
#15
Stephen Palmisano, Robert J Barry, Frances M De Blasio, Jack S Fogarty
This proof-of-concept study investigated whether a time-frequency EEG approach could be used to examine vection (i.e., illusions of self-motion). In the main experiment, we compared the event-related spectral perturbation (ERSP) data of 10 observers during and directly after repeated exposures to two different types of optic flow display (each was 35° wide by 29° high and provided 20 s of motion stimulation). Displays consisted of either a vection display (which simulated constant velocity forward self-motion in depth) or a control display (a spatially scrambled version of the vection display)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27520323/a-new-analytical-platform-based-on-field-flow-fractionation-and-olfactory-sensor-to-improve-the-detection-of-viable-and-non-viable-bacteria-in-food
#16
Barbara Roda, Mara Mirasoli, Andrea Zattoni, Monica Casale, Paolo Oliveri, Alessandro Bigi, Pierluigi Reschiglian, Patrizia Simoni, Aldo Roda
An integrated sensing system is presented for the first time, where a metal oxide semiconductor sensor-based electronic olfactory system (MOS array), employed for pathogen bacteria identification based on their volatile organic compound (VOC) characterisation, is assisted by a preliminary separative technique based on gravitational field-flow fractionation (GrFFF). In the integrated system, a preliminary step using GrFFF fractionation of a complex sample provided bacteria-enriched fractions readily available for subsequent MOS array analysis...
October 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27503070/multiple-allogeneic-progenitors-in-combination-function-as-a-unit-to-support-early-transient-hematopoiesis-in-transplantation
#17
Takashi Ishida, Satoshi Takahashi, Chen-Yi Lai, Masanori Nojima, Ryo Yamamoto, Emiko Takeuchi, Yasuo Takeuchi, Masaaki Higashihara, Hiromitsu Nakauchi, Makoto Otsu
Cord blood (CB) is a valuable donor source in hematopoietic cell transplantation. However, the initial time to engraftment in CB transplantation (CBT) is often delayed because of low graft cell numbers. This limits the use of CB. To overcome this cell dose barrier, we modeled an insufficient dose CBT setting in lethally irradiated mice and then added hematopoietic stem/progenitor cells (HSCs/HPCs; HSPCs) derived from four mouse allogeneic strains. The mixture of HSPCs rescued recipients and significantly accelerated hematopoietic recovery...
August 22, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27479448/electrospray-differential-mobility-hyphenated-with-single-particle-inductively-coupled-plasma-mass-spectrometry-for-characterization-of-nanoparticles-and-their-aggregates
#18
Jiaojie Tan, Jingyu Liu, Mingdong Li, Hind El Hadri, Vincent A Hackley, Michael R Zachariah
The novel hyphenation of electrospray-differential mobility analysis with single particle inductively coupled plasma mass spectrometry (ES-DMA-spICPMS) was demonstrated with the capacity for real-time size, mass, and concentration measurement of nanoparticles (NPs) on a particle-to-particle basis. In this proof-of-concept study, the feasibility of this technique was validated through both concentration and mass calibration using NIST gold NP reference materials. A detection limit of 10(5) NPs mL(-1) was determined under current experimental conditions, which is about 4 orders of magnitude lower in comparison to that of a traditional ES-DMA setup using a condensation particle counter as detector...
September 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27452369/discovering-regulated-metabolite-families-in-untargeted-metabolomics-studies
#19
Hendrik Treutler, Hiroshi Tsugawa, Andrea Porzel, Karin Gorzolka, Alain Tissier, Steffen Neumann, Gerd Ulrich Balcke
The identification of metabolites by mass spectrometry constitutes a major bottleneck which considerably limits the throughput of metabolomics studies in biomedical or plant research. Here, we present a novel approach to analyze metabolomics data from untargeted, data-independent LC-MS/MS measurements. By integrated analysis of MS(1) abundances and MS/MS spectra, the identification of regulated metabolite families is achieved. This approach offers a global view on metabolic regulation in comparative metabolomics...
August 16, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27400765/using-patient-specific-induced-pluripotent-stem-cells-and-wild-type-mice-to-develop-a-gene-augmentation-based-strategy-to-treat-cln3-associated-retinal-degeneration
#20
Luke A Wiley, Erin R Burnight, Arlene V Drack, Bailey B Banach, Dalyz Ochoa, Cathryn M Cranston, Robert A Madumba, Jade S East, Robert F Mullins, Edwin M Stone, Budd A Tucker
Juvenile neuronal ceroid lipofuscinosis (JNCL) is a childhood neurodegenerative disease with early-onset, severe central vision loss. Affected children develop seizures and CNS degeneration accompanied by severe motor and cognitive deficits. There is no cure for JNCL, and patients usually die during the second or third decade of life. In this study, independent lines of induced pluripotent stem cells (iPSCs) were generated from two patients with molecularly confirmed mutations in CLN3, the gene mutated in JNCL...
July 11, 2016: Human Gene Therapy
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