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https://www.readbyqxmd.com/read/28900188/decoding-finger-movement-in-humans-using-synergy-of-eeg-cortical-current-signals
#1
Natsue Yoshimura, Hayato Tsuda, Toshihiro Kawase, Hiroyuki Kambara, Yasuharu Koike
The synchronized activity of neuronal populations across multiple distant brain areas may reflect coordinated interactions of large-scale brain networks. Currently, there is no established method to investigate the temporal transitions between these large-scale networks that would allow, for example, to decode finger movements. Here we applied a matrix factorization method employing principal component and temporal independent component analyses to identify brain activity synchronizations. In accordance with previous studies investigating "muscle synergies", we refer to this activity as "brain activity synergy"...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892681/optimization-of-the-yield-of-dark-microaerobic-production-of-hydrogen-from-lactate-by-rhodopseudomonas-palustris
#2
Carolina Zampol Lazaro, Zeynep Yilmazer Hitit, Patrick C Hallenbeck
Hydrogen yields of dark fermentation are limited due to the need to also produce reduced side products, and photofermentation, an alternative, is limited by the need for light. A relatively new strategy, dark microaerobic fermentation, could potentially overcome both these constraints. Here, application of this strategy demonstrated for the first time significant hydrogen production from lactate by a single organism in the dark. Response surface methodology (RSM) was used to optimize substrate and oxygen concentration as well as inoculum using both (1) regular batch and (2) O2 fed batch cultures...
September 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28878778/multivariate-analysis-as-a-support-for-diagnostic-flowcharts-in-allergic-bronchopulmonary-aspergillosis-a-proof-of-concept-study
#3
Joana Vitte, Stéphane Ranque, Ania Carsin, Carine Gomez, Thomas Romain, Carole Cassagne, Marion Gouitaa, Mélisande Baravalle-Einaudi, Nathalie Stremler-Le Bel, Martine Reynaud-Gaubert, Jean-Christophe Dubus, Jean-Louis Mège, Jean Gaudart
Molecular-based allergy diagnosis yields multiple biomarker datasets. The classical diagnostic score for allergic bronchopulmonary aspergillosis (ABPA), a severe disease usually occurring in asthmatic patients and people with cystic fibrosis, comprises succinct immunological criteria formulated in 1977: total IgE, anti-Aspergillus fumigatus (Af) IgE, anti-Af "precipitins," and anti-Af IgG. Progress achieved over the last four decades led to multiple IgE and IgG(4) Af biomarkers available with quantitative, standardized, molecular-level reports...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28861130/using-expectancy-value-theory-as-a-framework-to-reduce-student-resistance-to-active-learning-a-proof-of-concept
#4
Katelyn M Cooper, Michael Ashley, Sara E Brownell
There has been a national movement to transition college science courses from passive lectures to active learning environments. Active learning has been shown to be a more effective way for students to learn, yet there is concern that some students are resistant to active learning approaches. Although there is much discussion about student resistance to active learning, few studies have explored this topic. Furthermore, a limited number of studies have applied theoretical frameworks to student engagement in active learning...
2017: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28841588/thrombosis-in-adult-patients-with-acute-leukemia
#5
Maria Ilaria Del Principe, Domenico Del Principe, Adriano Venditti
PURPOSE OF REVIEW: Recent studies indicate that the risk of thrombosis in hematologic patients may be similar or even higher than that found in patients with solid tumors. However, available information about pathogenesis and incidence of thrombosis in acute leukemia is limited. This review focuses on mechanisms underlying thrombosis in acute leukemia and discusses recent literature data. RECENT FINDINGS: In the last few years, proofs have been provided that leukemic cells release free prothrombotic products, such as micro-vesicles, tissue factors, circulating free DNA and RNA...
August 24, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28815143/analyzing-electronic-medical-records-to-predict-risk-of-dit-death-intubation-or-transfer-to-icu-in-pediatric-respiratory-failure-or-related-conditions
#6
Teeradache Viangteeravat, Oguz Akbilgic, Robert Lowell Davis
Large volumes of data are generated in hospital settings, including clinical and physiological data generated during the course of patient care. Our goal, as proof of concept, was to identify early clinical factors or traits useful for predicting the outcome, of death, intubation, or transfer to ICU, for children with pediatric respiratory failure. We implemented both supervised and unsupervised methods to extend our understanding on statistical relationships in clinical and physiological data. As a supervised learning method, we use binary logistic regression to predict the risk of developing DIT outcome...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28782187/sensitive-three-dimensional-ultrasound-assessment-of-carotid-atherosclerosis-by-weighted-average-of-local-vessel-wall-and-plaque-thickness-change
#7
Jieyu Cheng, Eranga Ukwatta, Shadi Shavakh, Tommy W S Chow, Grace Parraga, J David Spence, Bernard Chiu
PURPOSE: Vitamin B deficiency has been identified as a risk factor for vascular events. However, the reduction of vascular events was not shown in large randomized controlled trials evaluating B-Vitamin therapy. There is an important requirement to develop sensitive biomarkers to be used as efficacy targets for B-Vitamin therapy as well as other dietary treatments and lifestyle regimes that are being developed. Carotid vessel-wall-plus-plaque thickness change (VWT-Change) measured from 3D ultrasound has been shown to be sensitive to atorvastatin therapies in previous studies...
August 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28769778/improving-cross-day-eeg-based-emotion-classification-using-robust-principal-component-analysis
#8
Yuan-Pin Lin, Ping-Keng Jao, Yi-Hsuan Yang
Constructing a robust emotion-aware analytical framework using non-invasively recorded electroencephalogram (EEG) signals has gained intensive attentions nowadays. However, as deploying a laboratory-oriented proof-of-concept study toward real-world applications, researchers are now facing an ecological challenge that the EEG patterns recorded in real life substantially change across days (i.e., day-to-day variability), arguably making the pre-defined predictive model vulnerable to the given EEG signals of a separate day...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28715339/development-of-a-low-cost-medical-ultrasound-scanner-using-a-monostatic-synthetic-aperture
#9
Thomas L A van den Heuvel, David J Graham, Kristopher J Smith, Chris L de Korte, Jeffrey A Neasham
OBJECTIVE: In this paper, we present the design of low-cost medical ultrasound scanners aimed at the detection of maternal mortality risk factors in developing countries. METHOD: Modern ultrasound scanners typically employ a high element count transducer array with multichannel transmit and receive electronics. To minimize hardware costs, we employ a single piezoelectric element, mechanically swept across the target scene, and a highly cost-engineered single channel acquisition circuit...
August 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28715259/teaching-principal-components-using-correlations
#10
Peter H Westfall, Andrea L Arias, Larry V Fulton
Introducing principal components (PCs) to students is difficult. First, the matrix algebra and mathematical maximization lemmas are daunting, especially for students in the social and behavioral sciences. Second, the standard motivation involving variance maximization subject to unit length constraint does not directly connect to the "variance explained" interpretation. Third, the unit length and uncorrelatedness constraints of the standard motivation do not allow re-scaling or oblique rotations, which are common in practice...
July 17, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/28686252/fourier-transform-infrared-spectroscopy-for-characterization-of-protein-chain-reductions-in-enzymatic-reactions
#11
Ulrike Böcker, Sileshi Gizachew Wubshet, Diana Lindberg, Nils Kristian Afseth
The potential of dry-film Fourier-transform infrared (FTIR) measurements as a monitoring tool for enzymatic hydrolysis of protein-based substrates is explored in this study. As a proof-of-concept, the enzymatic digestion of bovine serum albumin using Alcalase was monitored. To evaluate the analytical approach on complex substrates with industrial relevance, salmon- and chicken-based substrates were digested for 80 minutes using Alcalase and a total of 12 FTIR spectra were acquired during the course of the hydrolysis...
July 24, 2017: Analyst
https://www.readbyqxmd.com/read/28667999/a-compact-linear-accelerator-based-on-a-scalable-microelectromechanical-system-rf-structure
#12
A Persaud, Q Ji, E Feinberg, P A Seidl, W L Waldron, T Schenkel, A Lal, K B Vinayakumar, S Ardanuc, D A Hammer
A new approach for a compact radio-frequency (RF) accelerator structure is presented. The new accelerator architecture is based on the Multiple Electrostatic Quadrupole Array Linear Accelerator (MEQALAC) structure that was first developed in the 1980s. The MEQALAC utilized RF resonators producing the accelerating fields and providing for higher beam currents through parallel beamlets focused using arrays of electrostatic quadrupoles (ESQs). While the early work obtained ESQs with lateral dimensions on the order of a few centimeters, using a printed circuit board (PCB), we reduce the characteristic dimension to the millimeter regime, while massively scaling up the potential number of parallel beamlets...
June 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28626990/exhaled-breath-profiles-in-the-monitoring-of-loss-of-control-and-clinical-recovery-in-asthma
#13
P Brinkman, M A van de Pol, M G Gerritsen, L D Bos, T Dekker, B S Smids, A Sinha, C J Majoor, M M Sneeboer, H H Knobel, T J Vink, F H de Jongh, R Lutter, P J Sterk, N Fens
BACKGROUND: Asthma is a chronic inflammatory airway disease, associated with episodes of exacerbations. Therapy with inhaled corticosteroids (ICS) targets airway inflammation, which aims to maintain and restore asthma control. Clinical features are only modestly associated with airways inflammation. Therefore, we hypothesized that exhaled volatile metabolites identify longitudinal changes between clinically stable episodes and loss of asthma control. OBJECTIVES: To determine whether exhaled volatile organic compounds (VOCs) as measured by gas-chromatography/mass-spectrometry (GC/MS) and electronic nose (eNose) technology discriminate between clinically stable and unstable episodes of asthma...
June 19, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28613951/the-fantasy-questionnaire-a-measure-to-assess-creative-and-imaginative-fantasy
#14
David Weibel, Corinna S Martarelli, Diego Häberli, Fred W Mast
This article reports the construction and validation of a comprehensive self-report measure of fantasy. Unlike previous measures of fantasy, which focus on psychopathology, we conceive fantasy as a trait with positive connotation. Principal component analysis (N = 318) and confirmatory factor analyses (N = 345) were conducted using 2 sociodemographically diverse samples. The results provided support for a 2-factor conceptualization of the construct, with the dimensions imaginative fantasy and creative fantasy...
June 14, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28590411/a-conjugate-of-pentamethine-cyanine-and-18-f-as-a-positron-emission-tomography-near-infrared-fluorescence-probe-for-multimodality-tumor-imaging
#15
Fei-Fei An, Harikrishna Kommidi, Nandi Chen, Richard Ting
The novel synthesis of a dual-modality, pentamethine cyanine (Cy5) fluorescent, (18)F positron emission tomography (PET) imaging probe is reported. The probe shows a large extinction coefficient and large quantum yield in the biologically transparent, near-infrared window (650-900 nm) for in vivo fluorescent imaging. This fluorophore bears the isotope, (18)F, giving a (18)F-PET/near-infrared fluorescent (NIRF), bi-modal imaging probe, that combines the long-term stability of NIRF and the unlimited penetration depth of PET imaging...
June 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28586508/overexpressing-wild-type-%C3%AE-2-subunits-rescued-the-seizure-phenotype-in-gabrg2-q390x-dravet-syndrome-mice
#16
Xuan Huang, Chengwen Zhou, Mengnan Tian, Jing-Qiong Kang, Wangzhen Shen, Kelienne Verdier, Aurea Pimenta, Robert L MacDonald
OBJECTIVE: The mutant γ-aminobutyric acid type A (GABAA ) receptor γ2(Q390X) subunit (Q351X in the mature peptide) has been associated with the epileptic encephalopathy, Dravet syndrome, and the epilepsy syndrome genetic epilepsy with febrile seizures plus (GEFS+). The mutation generates a premature stop codon that results in translation of a stable truncated and misfolded γ2 subunit that accumulates in neurons, forms intracellular aggregates, disrupts incorporation of γ2 subunits into GABAA receptors, and affects trafficking of partnering α and β subunits...
August 2017: Epilepsia
https://www.readbyqxmd.com/read/28553679/computational-modelling-of-wounded-tissue-subject-to-negative-pressure-wound-therapy-following-trans-femoral-amputation
#17
B Zeybek, S Li, J W Fernandez, S Stapley, V V Silberschmidt, Y Liu
Proof-of-concept computational models were developed and applied as tools to gain insights into biomechanical interactions and variations of oxygen gradients of wounded tissue subject to negative pressure wound therapy (NPWT), following trans-femoral amputation. A macro-scale finite-element model of a lower limb was first developed based on computed tomography data, and distributions of maximum and minimum principal stress values we calculated for a region of interest (ROI). Then, the obtained results were applied iteratively as new sets of boundary conditions for a specific spatial position in a capillary sub-model...
May 28, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28544071/a-prospective-randomized-controlled-trial-for-assessment-of-perineal-hydrodissection-technique-for-nervesparing-robot-assisted-radical-prostatectomy
#18
G Hatiboglu, T Simpfendörfer, L Uhlmann, M A Bergero, S Macher-Goeppinger, S Pahernik, B Hadaschik, M Hohenfellner, D Teber
BACKGROUND: This study prospectively evaluated the safety and efficacy of perineal hydrodissection in robot assisted nervesparing prostatectomy. METHODS: Patients were randomized for perineal, ultrasound guided hydrodissection (HD) before radical prostatectomy and compared with standard treatment (ST). Follow-up was done every 3 months, including erectile function (IIEF5-score), reported grade of erection, ability for sexual intercourse, continence, PSA. RESULTS: 21 patients were enrolled to this prospective study, 10 for ST and 11 for HD...
May 23, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28512630/hand-grasping-synergies-as-biometrics
#19
Vrajeshri Patel, Poojita Thukral, Martin K Burns, Ionut Florescu, Rajarathnam Chandramouli, Ramana Vinjamuri
Recently, the need for more secure identity verification systems has driven researchers to explore other sources of biometrics. This includes iris patterns, palm print, hand geometry, facial recognition, and movement patterns (hand motion, gait, and eye movements). Identity verification systems may benefit from the complexity of human movement that integrates multiple levels of control (neural, muscular, and kinematic). Using principal component analysis, we extracted spatiotemporal hand synergies (movement synergies) from an object grasping dataset to explore their use as a potential biometric...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28507922/sofosbuvir-use-in-the-setting-of-end-stage-renal-disease-a-single-center-experience
#20
Avin Aggarwal, Eric R Yoo, Ryan B Perumpail, George Cholankeril, Radhika Kumari, Tami J Daugherty, Alex S Lapasaran, Aijaz Ahmed
Background and Aims: Patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) who are dialysis-dependent form a unique group, in which safety, tolerability and efficacy of sofosbuvir (SOF)-based direct-acting antivirals (DAAs) need further evaluation. Methods: We performed a retrospective analysis of 14 patients with CHC and ESRD on dialysis who received 15 courses of SOF-based therapy. We evaluated dose escalation to standard-dose SOF in this proof-of-principle experience. Results: Sustained virological response (defined as undetectable viral load at 12 weeks, SVR-12) was achieved in 13 out of the 15 (86...
March 28, 2017: Journal of Clinical and Translational Hepatology
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