keyword
MENU ▼
Read by QxMD icon Read
search

Proof of principal

keyword
https://www.readbyqxmd.com/read/29135026/sensory-and-flavor-characteristics-of-tomato-juice-from-garden-gem-and-roma-tomatoes-with-comparison-to-commercial-tomato-juice
#1
Yaozhou Zhu, Charles A Sims, Harry J Klee, Paul J Sarnoski
The objective of this study was to characterize the flavor of a premium Florida tomato variety that has significant potential for producing a high quality processed juice product. A high-quality Florida plum tomato variety (Garden Gem), and a typical grocery-store plum tomato variety (Roma) were thermally processed into tomato juices without any additives. The 2 pilot products and a popular commercially available tomato juice (low sodium with sugar and flavor added) were compared using sensory evaluation and instrumental analysis...
November 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29130686/thioamide-substitution-selectively-modulates-proteolysis-and-receptor-activity-of-therapeutic-peptide-hormones
#2
Xing Chen, Elizabeth G Mietlicki-Baase, Taylor M Barrett, Lauren E McGrath, Kieran Koch-Laskowski, John J Ferrie, Matthew R Hayes, E James Petersson
Peptide hormones are attractive as injectable therapeutics and imaging agents, but they often require extensive modification by mutagenesis and/or chemical synthesis to prevent rapid in vivo degradation. Alternatively, the single-atom, O-to-S modification of peptide backbone thioamidation has the potential to selectively perturb interactions with proteases while preserving interactions with other proteins, such as target receptors. Here, we use the validated diabetes therapeutic, glucagon-like peptide-1 (GLP-1), and the target of clinical investigation, gastric inhibitory polypeptide (GIP), as proof-of-principle peptides to demonstrate the value of thioamide substitution...
November 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29107219/adult-fly-age-estimations-using-cuticular-hydrocarbons-and-artificial-neural-networks-in-forensically-important-calliphoridae-species
#3
Hannah E Moore, John B Butcher, Charles R Day, Falko P Drijfhout
Blowflies (Diptera: Calliphoridae) are forensically important as they are known to be one of the first to colonise human remains. The larval stage is typically used to assist a forensic entomologists with adult flies rarely used as they are difficult to age because they remain morphologically similar once they have gone through the initial transformation upon hatching. However, being able to age them is of interest and importance within the field. This study examined the cuticular hydrocarbons (CHC) of Diptera: Calliphoridae species Lucilia sericata, Calliphora vicina and Calliphora vomitoria...
October 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29064247/in-situ-stimulation-of-thiocyanate-biodegradation-through-phosphate-amendment-in-gold-mine-tailings-water
#4
Mathew P Watts, Han M Gan, Lee Y Peng, Kim-Anh Lê Cao, John W Moreau
Thiocyanate (SCN(-)) is a contaminant requiring remediation in gold mine tailings and wastewaters globally. Seepage of SCN(-)-contaminated waters into aquifers can occur from unlined or structurally compromised mine tailings storage facilities. A wide variety of microorganisms are known to be capable of biodegrading SCN(-); however, little is known regarding the potential of native microbes for in situ SCN(-) biodegradation, a remediation option that is less costly than engineered approaches. Here we experimentally characterize the principal biogeochemical barrier to SCN(-) biodegradation for an autotrophic microbial consortium enriched from mine tailings, to arrive at an environmentally realistic assessment of in situ SCN(-) biodegradation potential...
November 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29060471/kernel-based-adaptive-learning-improves-accuracy-of-glucose-predictive-modelling-in-type-1-diabetes-a-proof-of-concept-study
#5
Eleni I Georga, Jose C Principe, Evangelos C Rizos, Dimitrios I Fotiadis
This study aims at demonstrating the need for nonlinear recursive models to the identification and prediction of the dynamic glucose system in type 1 diabetes. Nonlinear regression is performed in a reproducing kernel Hilbert space, by the Approximate Linear Dependency Kernel Recursive Least Squares (KRLS-ALD) algorithm, such that a sparse model structure is accomplished. The method is evaluated on seven people with type 1 diabetes in free-living conditions, where a change in glycaemic dynamics is forced by increasing the level of physical activity in the middle of the observational period...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28975197/association-of-multiorgan-computed-tomographic-phenomap-with-adverse-cardiovascular-health-outcomes-the-framingham-heart-study
#6
Ravi V Shah, Ashish S Yeri, Venkatesh L Murthy, Joe M Massaro, Ralph D'Agostino, Jane E Freedman, Michelle T Long, Caroline S Fox, Saumya Das, Emelia J Benjamin, Ramachandran S Vasan, Christopher J O'Donnell, Udo Hoffmann
Importance: Increased ability to quantify anatomical phenotypes across multiple organs provides the opportunity to assess their cumulative ability to identify individuals at greatest susceptibility for adverse outcomes. Objective: To apply unsupervised machine learning to define the distribution and prognostic importance of computed tomography-based multiorgan phenotypes associated with adverse health outcomes. Design, Setting, and Participants: This asymptomatic community-based cohort study included 2924 Framingham Heart Study participants between July 2002 and April 2005 undergoing computed tomographic imaging of the chest and abdomen...
November 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28969656/inadequate-programming-insufficient-communication-and-non-compliance-with-the-basic-principles-of-maternal-death-audits-in-health-districts-in-burkina-faso-a-qualitative-study
#7
Boukaré Congo, Djénéba Sanon, Tieba Millogo, Charlemagne Marie Ouedraogo, Wambi Maurice E Yaméogo, Ziemlé Clement Meda, Seni Kouanda
BACKGROUND: Implementation of quality maternal death audits requires good programming, good communication and compliance with core principles. Studies on compliance with core principles in the conduct of maternal death audits (MDAs) exist but were conducted in urban areas, at the 2nd or 3rd level of the healthcare system, in experimental situations, or in a context of skills-building projects or technical platforms with an emphasis on the review of "near miss". This study aims to fill the gap of evidence on the implementation of MDAs in rural settings, at the first level of care and in the routine care situation in Burkina Faso...
September 29, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28900188/decoding-finger-movement-in-humans-using-synergy-of-eeg-cortical-current-signals
#8
Natsue Yoshimura, Hayato Tsuda, Toshihiro Kawase, Hiroyuki Kambara, Yasuharu Koike
The synchronized activity of neuronal populations across multiple distant brain areas may reflect coordinated interactions of large-scale brain networks. Currently, there is no established method to investigate the temporal transitions between these large-scale networks that would allow, for example, to decode finger movements. Here we applied a matrix factorization method employing principal component and temporal independent component analyses to identify brain activity synchronizations. In accordance with previous studies investigating "muscle synergies", we refer to this activity as "brain activity synergy"...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892681/optimization-of-the-yield-of-dark-microaerobic-production-of-hydrogen-from-lactate-by-rhodopseudomonas-palustris
#9
Carolina Zampol Lazaro, Zeynep Yilmazer Hitit, Patrick C Hallenbeck
Hydrogen yields of dark fermentation are limited due to the need to also produce reduced side products, and photofermentation, an alternative, is limited by the need for light. A relatively new strategy, dark microaerobic fermentation, could potentially overcome both these constraints. Here, application of this strategy demonstrated for the first time significant hydrogen production from lactate by a single organism in the dark. Response surface methodology (RSM) was used to optimize substrate and oxygen concentration as well as inoculum using both (1) regular batch and (2) O2 fed batch cultures...
December 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28878778/multivariate-analysis-as-a-support-for-diagnostic-flowcharts-in-allergic-bronchopulmonary-aspergillosis-a-proof-of-concept-study
#10
Joana Vitte, Stéphane Ranque, Ania Carsin, Carine Gomez, Thomas Romain, Carole Cassagne, Marion Gouitaa, Mélisande Baravalle-Einaudi, Nathalie Stremler-Le Bel, Martine Reynaud-Gaubert, Jean-Christophe Dubus, Jean-Louis Mège, Jean Gaudart
Molecular-based allergy diagnosis yields multiple biomarker datasets. The classical diagnostic score for allergic bronchopulmonary aspergillosis (ABPA), a severe disease usually occurring in asthmatic patients and people with cystic fibrosis, comprises succinct immunological criteria formulated in 1977: total IgE, anti-Aspergillus fumigatus (Af) IgE, anti-Af "precipitins," and anti-Af IgG. Progress achieved over the last four decades led to multiple IgE and IgG(4) Af biomarkers available with quantitative, standardized, molecular-level reports...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28861130/using-expectancy-value-theory-as-a-framework-to-reduce-student-resistance-to-active-learning-a-proof-of-concept
#11
Katelyn M Cooper, Michael Ashley, Sara E Brownell
There has been a national movement to transition college science courses from passive lectures to active learning environments. Active learning has been shown to be a more effective way for students to learn, yet there is concern that some students are resistant to active learning approaches. Although there is much discussion about student resistance to active learning, few studies have explored this topic. Furthermore, a limited number of studies have applied theoretical frameworks to student engagement in active learning...
2017: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28841588/thrombosis-in-adult-patients-with-acute-leukemia
#12
Maria Ilaria Del Principe, Domenico Del Principe, Adriano Venditti
PURPOSE OF REVIEW: Recent studies indicate that the risk of thrombosis in hematologic patients may be similar or even higher than that found in patients with solid tumors. However, available information about pathogenesis and incidence of thrombosis in acute leukemia is limited. This review focuses on mechanisms underlying thrombosis in acute leukemia and discusses recent literature data. RECENT FINDINGS: In the last few years, proofs have been provided that leukemic cells release free prothrombotic products, such as micro-vesicles, tissue factors, circulating free DNA and RNA...
November 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28815143/analyzing-electronic-medical-records-to-predict-risk-of-dit-death-intubation-or-transfer-to-icu-in-pediatric-respiratory-failure-or-related-conditions
#13
Teeradache Viangteeravat, Oguz Akbilgic, Robert Lowell Davis
Large volumes of data are generated in hospital settings, including clinical and physiological data generated during the course of patient care. Our goal, as proof of concept, was to identify early clinical factors or traits useful for predicting the outcome, of death, intubation, or transfer to ICU, for children with pediatric respiratory failure. We implemented both supervised and unsupervised methods to extend our understanding on statistical relationships in clinical and physiological data. As a supervised learning method, we use binary logistic regression to predict the risk of developing DIT outcome...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28782187/sensitive-three-dimensional-ultrasound-assessment-of-carotid-atherosclerosis-by-weighted-average-of-local-vessel-wall-and-plaque-thickness-change
#14
Jieyu Cheng, Eranga Ukwatta, Shadi Shavakh, Tommy W S Chow, Grace Parraga, J David Spence, Bernard Chiu
PURPOSE: Vitamin B deficiency has been identified as a risk factor for vascular events. However, the reduction of vascular events was not shown in large randomized controlled trials evaluating B-Vitamin therapy. There is an important requirement to develop sensitive biomarkers to be used as efficacy targets for B-Vitamin therapy as well as other dietary treatments and lifestyle regimes that are being developed. Carotid vessel-wall-plus-plaque thickness change (VWT-Change) measured from 3D ultrasound has been shown to be sensitive to atorvastatin therapies in previous studies...
October 2017: Medical Physics
https://www.readbyqxmd.com/read/28769778/improving-cross-day-eeg-based-emotion-classification-using-robust-principal-component-analysis
#15
Yuan-Pin Lin, Ping-Keng Jao, Yi-Hsuan Yang
Constructing a robust emotion-aware analytical framework using non-invasively recorded electroencephalogram (EEG) signals has gained intensive attentions nowadays. However, as deploying a laboratory-oriented proof-of-concept study toward real-world applications, researchers are now facing an ecological challenge that the EEG patterns recorded in real life substantially change across days (i.e., day-to-day variability), arguably making the pre-defined predictive model vulnerable to the given EEG signals of a separate day...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28715339/development-of-a-low-cost-medical-ultrasound-scanner-using-a-monostatic-synthetic-aperture
#16
Thomas L A van den Heuvel, David J Graham, Kristopher J Smith, Chris L de Korte, Jeffrey A Neasham
OBJECTIVE: In this paper, we present the design of low-cost medical ultrasound scanners aimed at the detection of maternal mortality risk factors in developing countries. METHOD: Modern ultrasound scanners typically employ a high element count transducer array with multichannel transmit and receive electronics. To minimize hardware costs, we employ a single piezoelectric element, mechanically swept across the target scene, and a highly cost-engineered single channel acquisition circuit...
August 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28715259/teaching-principal-components-using-correlations
#17
Peter H Westfall, Andrea L Arias, Larry V Fulton
Introducing principal components (PCs) to students is difficult. First, the matrix algebra and mathematical maximization lemmas are daunting, especially for students in the social and behavioral sciences. Second, the standard motivation involving variance maximization subject to unit length constraint does not directly connect to the "variance explained" interpretation. Third, the unit length and uncorrelatedness constraints of the standard motivation do not allow re-scaling or oblique rotations, which are common in practice...
July 17, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/28686252/fourier-transform-infrared-spectroscopy-for-characterization-of-protein-chain-reductions-in-enzymatic-reactions
#18
Ulrike Böcker, Sileshi Gizachew Wubshet, Diana Lindberg, Nils Kristian Afseth
The potential of dry-film Fourier-transform infrared (FTIR) measurements as a monitoring tool for enzymatic hydrolysis of protein-based substrates is explored in this study. As a proof-of-concept, the enzymatic digestion of bovine serum albumin using Alcalase was monitored. To evaluate the analytical approach on complex substrates with industrial relevance, salmon- and chicken-based substrates were digested for 80 minutes using Alcalase and a total of 12 FTIR spectra were acquired during the course of the hydrolysis...
July 24, 2017: Analyst
https://www.readbyqxmd.com/read/28667999/a-compact-linear-accelerator-based-on-a-scalable-microelectromechanical-system-rf-structure
#19
A Persaud, Q Ji, E Feinberg, P A Seidl, W L Waldron, T Schenkel, A Lal, K B Vinayakumar, S Ardanuc, D A Hammer
A new approach for a compact radio-frequency (RF) accelerator structure is presented. The new accelerator architecture is based on the Multiple Electrostatic Quadrupole Array Linear Accelerator (MEQALAC) structure that was first developed in the 1980s. The MEQALAC utilized RF resonators producing the accelerating fields and providing for higher beam currents through parallel beamlets focused using arrays of electrostatic quadrupoles (ESQs). While the early work obtained ESQs with lateral dimensions on the order of a few centimeters, using a printed circuit board (PCB), we reduce the characteristic dimension to the millimeter regime, while massively scaling up the potential number of parallel beamlets...
June 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28626990/exhaled-breath-profiles-in-the-monitoring-of-loss-of-control-and-clinical-recovery-in-asthma
#20
P Brinkman, M A van de Pol, M G Gerritsen, L D Bos, T Dekker, B S Smids, A Sinha, C J Majoor, M M Sneeboer, H H Knobel, T J Vink, F H de Jongh, R Lutter, P J Sterk, N Fens
BACKGROUND: Asthma is a chronic inflammatory airway disease, associated with episodes of exacerbations. Therapy with inhaled corticosteroids (ICS) targets airway inflammation, which aims to maintain and restore asthma control. Clinical features are only modestly associated with airways inflammation. Therefore, we hypothesized that exhaled volatile metabolites identify longitudinal changes between clinically stable episodes and loss of asthma control. OBJECTIVES: To determine whether exhaled volatile organic compounds (VOCs) as measured by gas-chromatography/mass-spectrometry (GC/MS) and electronic nose (eNose) technology discriminate between clinically stable and unstable episodes of asthma...
June 19, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
keyword
keyword
57910
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"