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https://www.readbyqxmd.com/read/29774211/3d-printed-e-tongue
#1
Gabriel Gaál, Tatiana A da Silva, Vladimir Gaál, Rafael C Hensel, Lucas R Amaral, Varlei Rodrigues, Antonio Riul
Nowadays, one of the biggest issues addressed to electronic sensor fabrication is the build-up of efficient electrodes as an alternative way to the expensive, complex and multistage processes required by traditional techniques. Printed electronics arises as an interesting alternative to fulfill this task due to the simplicity and speed to stamp electrodes on various surfaces. Within this context, the Fused Deposition Modeling 3D printing is an emerging, cost-effective and alternative technology to fabricate complex structures that potentiates several fields with more creative ideas and new materials for a rapid prototyping of devices...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29772057/a-4d-global-respiratory-motion-model-of-the-thorax-based-on-ct-images-a-proof-of-concept
#2
H Fayad, M Gilles, T Pan, D Visvikis
PURPOSE: Respiratory motion reduces the sensitivity and specificity of medical images especially in the thoracic and abdominal areas. It may affect applications such as cancer diagnostic imaging and/or radiation therapy (RT). Solutions to this issue include modelling of the respiratory motion in order to optimize both diagnostic and therapeutic protocols. Personalised motion modeling required patient specific four dimensional (4D) imaging which in the case of 4D computed tomography (4D CT) acquisition is associated with an increased dose...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29763337/raman-spectroscopy-for-inverted-papilloma-a-proof-of-concept-study
#3
Marco A Mascarella, Abdulaziz Alrasheed, Naif Fnais, Ophelie Gourgas, Ghulam Jalani, Marta Cerruti, Marc A Tewfik
Inverted papillomas are tumors of the sinonasal tract with a propensity to recur. Raman spectroscopy can potentially identify inverted papillomas from other tissue based on biochemical signatures. A pilot study comparing Raman spectroscopy to histopathology for 3 types of sinonasal tissue was performed. Spectral data of biopsies from patients with normal sinonasal mucosa, chronic rhinosinusitis, and inverted papillomas are compared to histopathology using principal component analysis and linear discriminant analysis after data preprocessing...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29758500/degradation-of-aniline-by-electrochemical-activation-of-peroxydisulfate-at-mwcnt-cathode-the-proofed-concept-of-nonradical-oxidation-process
#4
Chunyang Nie, Zhimin Ao, Xiaoguang Duan, Chengying Wang, Shaobin Wang, Taicheng An
Enhanced elimination of aniline in aqueous solution was achieved by coupling electrosorption of aniline and electrochemical activation of peroxydisulfate (PDS) at multi-walled carbon nanotube (MWCNT) cathode, in which a synergistic effect occurred. It was found that PDS could be effectively activated under a small voltage at MWCNT cathode owing to the specific pore structures of MWCNTs. A nonradical oxidation pathway instead of radical-based oxidation was proposed from the cathodic activation of PDS, wherein PDS molecules with a modified electronic structure was suggested to be the principal reactive species...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29753881/confocal-fluorescence-imaging-to-evaluate-the-effect-of-antimicrobial-photodynamic-therapy-depth-on-p-gingivalis-and-t-denticola-biofilms
#5
Stephen Rogers, Kiyonobu Honma, Thomas S Mang
BACKGROUND: Porphyromonas gingivalis and Treponema denticola are both principally implicated in the incidence of both periodontal disease and peri-implantitis. Recent studies have demonstrated that these bacteria exhibit symbiotic growth in vitro and a synergistic virulence in co-infection of animal models. Found at varying depths throughout the biofilm, these bacteria present a significant challenge to traditional antimicrobial treatment modalities. Antimicrobial photodynamic therapy ( aPDT ) has yielded high success against bacterial biofilms, namely those found in the oral cavity...
May 10, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29742587/exploratory-application-of-neuropharmacometabolomics-in-severe-childhood-traumatic-brain-injury
#6
Fanuel T Hagos, Philip E Empey, Pengcheng Wang, Xiaochao Ma, Samuel M Poloyac, Hülya Bayır, Patrick M Kochanek, Michael J Bell, Robert S B Clark
OBJECTIVES: To employ metabolomics-based pathway and network analyses to evaluate the cerebrospinal fluid metabolome after severe traumatic brain injury in children and the capacity of combination therapy with probenecid and N-acetylcysteine to impact glutathione-related and other pathways and networks, relative to placebo treatment. DESIGN: Analysis of cerebrospinal fluid obtained from children enrolled in an Institutional Review Board-approved, randomized, placebo-controlled trial of a combination of probenecid and N-acetylcysteine after severe traumatic brain injury (Trial Registration NCT01322009)...
May 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29718032/revealing-the-principal-attributes-of-protein-adsorption-on-block-copolymer-surfaces-with-direct-experimental-evidence-at-the-single-protein-level
#7
Tian Xie, Joyjit Chattoraj, Patrick J Mulcahey, Noah P Kelleher, Emanuela Del Gado, Jong-In Hahm
Understanding protein adsorption onto polymer surfaces is of great importance in designing biomaterials, improving bioanalytical devices, and controlling biofouling, to name a few examples. Although steady research efforts have been advancing this field, our knowledge of this ubiquitous and complex phenomenon is still limited. In this study, we elucidate competitive protein adsorption behaviors sequentially occurring onto nanoscale block copolymer (BCP) surfaces via combined experimental and computer simulation approaches...
May 2, 2018: Nanoscale
https://www.readbyqxmd.com/read/29700659/mathematical-basis-of-predicting-dominant-function-in-protein-sequences-by-a-generic-hmm-ann-algorithm
#8
Siddhartha Kundu
The accurate annotation of an unknown protein sequence depends on extant data of template sequences. This could be empirical or sets of reference sequences, and provides an exhaustive pool of probable functions. Individual methods of predicting dominant function possess shortcomings such as varying degrees of inter-sequence redundancy, arbitrary domain inclusion thresholds, heterogeneous parameterization protocols, and ill-conditioned input channels. Here, I present a rigorous theoretical derivation of various steps of a generic algorithm that integrates and utilizes several statistical methods to predict the dominant function in unknown protein sequences...
April 26, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29666568/biologically-inspired-spike-based-automatic-speech-recognition-of-isolated-digits-over-a-reproducing-kernel-hilbert-space
#9
Kan Li, José C Príncipe
This paper presents a novel real-time dynamic framework for quantifying time-series structure in spoken words using spikes. Audio signals are converted into multi-channel spike trains using a biologically-inspired leaky integrate-and-fire (LIF) spike generator. These spike trains are mapped into a function space of infinite dimension, i.e., a Reproducing Kernel Hilbert Space (RKHS) using point-process kernels, where a state-space model learns the dynamics of the multidimensional spike input using gradient descent learning...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29650789/reparameterization-of-pam50-expression-identifies-novel-breast-tumor-dimensions-and-leads-to-discovery-of-a-genomewide-significant-breast-cancer-locus-at-12q15
#10
Michael J Madsen, Stacey Knight, Carol Sweeney, Rachel E Factor, Mohamed E Salama, Inge J Stijleman, Venkatesh Rajamanickam, Bryan E Welm, Sasi Arunachalam, Brandt Jones, Rakesh Rachamadugu, Kerry Rowe, Melissa Cessna, Alun Thomas, Lawrence H Kushi, Bette Caan, Philip S Bernard, Nicola J Camp
BACKGROUND: Breast tumor subtyping has failed to provide impact in susceptibility genetics. The PAM50 assay categorizes breast tumors into: Luminal A, Luminal B, HER2-enriched and Basal-like. However, tumors are often more complex than simple categorization can describe. The identification of heritable tumor characteristics has potential to decrease heterogeneity and increase power for gene-finding. METHODS: We used 911 sporadic breast tumors with PAM50 expression data to derive tumor dimensions using principal components (PC)...
April 12, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29628759/the-development-of-azd7624-for-prevention-of-exacerbations-in-copd-a-randomized-controlled-trial
#11
Naimish R Patel, Danen M Cunoosamy, Malin Fagerås, Ziad Taib, Sara Asimus, Tove Hegelund-Myrbäck, Sofia Lundin, Katerina Pardali, Nisha Kurian, Eva Ersdal, Cecilia Kristensson, Katarina Korsback, Robert Palmér, Mary N Brown, Steven Greenaway, Leonard Siew, Graham W Clarke, Stephen I Rennard, Barry J Make, Robert A Wise, Paul Jansson
Background: p38 mitogen-activated protein kinase (MAPK) plays a central role in the regulation and activation of pro-inflammatory mediators. COPD patients have increased levels of activated p38 MAPK, which correlate with increased lung function impairment, alveolar wall inflammation, and COPD exacerbations. Objectives: These studies aimed to assess the effect of p38 inhibition with AZD7624 in healthy volunteers and patients with COPD. The principal hypothesis was that decreasing lung inflammation via inhibition of p38α would reduce exacerbations and improve quality of life for COPD patients at high risk for acute exacerbations...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29625113/exosomal-proteome-analysis-of-human-plasma-to-monitor-sepsis-progression
#12
Yan Xu, Xin Ku, Chunrong Wu, Chunlin Cai, Jianguo Tang, Wei Yan
Exosomes are cell-derived vesicles containing RNA, lipid, and protein, which act in body immune response, intercellular signaling and some other important biological processes. Exosomes have been extensively studied in the past several years on their disease related mechanisms and potential roles to monitor disease progression as biomarkers. Compared with analyzing exosome RNA, comprehensive proteome profiling of exosomes in clinical samples (e.g. blood) are highly demanded but limited mainly due to lack of a reproducible method for efficient exosome extraction...
May 23, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29576703/identification-of-three-kinds-of-citri-reticulatae-pericarpium-based-on-deoxyribonucleic-acid-barcoding-and-high-performance-liquid-chromatography-diode-array-detection-electrospray-ionization-mass-spectrometry-mass-spectrometry-combined-with-chemometric-analysis
#13
Xiaoxue Yu, Yafeng Zhang, Dongmei Wang, Lin Jiang, Xinjun Xu
Background: Citri Reticulatae Pericarpium is the dried mature pericarp of Citrus reticulata Blanco which can be divided into "Chenpi" and "Guangchenpi." "Guangchenpi" is the genuine Chinese medicinal material in Xinhui, Guangdong province; based on the greatest quality and least amount, it is most expensive among others. Hesperidin is used as the marker to identify Citri Reticulatae Pericarpium described in the Chinese Pharmacopoeia 2010. However, both "Chenpi" and "Guangchenpi" contain hesperidin so that it is impossible to differentiate them by measuring hesperidin...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29573274/listen-to-the-public-and-fulfil-their-information-interests-translating-vaccine-communication-research-findings-into-guidance-for-regulators
#14
REVIEW
Priya Bahri, Mireia Castillon Melero
Regulatory authorities have a crucial role in communicating about vaccines they license. In terms of content and timing, their communication to the public is usually driven by data on quality, safety and efficacy. However, concerns over safety and vaccine hesitancy have emerged in some communities of various countries, and this demands a new approach to communication, starting with listening to the public debate. Reviewing communication research findings, coming in particular from the cognitive, decision-making and media sciences, constitutes one mechanism of listening and has led the European Union regulatory network to developing guidance about which common concerns and information needs of the public to address through proactive and prepared communication...
March 24, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29564677/-apping-up-prospects-for-information-technology-innovation-in-return-to-work-communication
#15
Ripdaman Singh, Fergal O'Hagan
Purpose During return to work (RTW), communication between health care providers and employers largely takes place through standardize paper-based forms. Information technology (IT) platforms may provide advantages in enabling information exchange and decision-making through sharing of guidelines and resources. We investigated stakeholder perspectives on the prospect of IT use for RTW communication in Ontario, Canada. Methods Consistent with the exploratory nature of the questions, qualitative methods were used...
March 21, 2018: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/29556738/aptamer-facilitated-mass-cytometry
#16
Gleb G Mironov, Alexandre Bouzekri, Jessica Watson, Olga Loboda, Olga Ornatsky, Maxim V Berezovski
Mass cytometry is a novel cell-by-cell analysis technique, which uses elemental tags instead of fluorophores. Sample cells undergo rapid ionization in inductively coupled plasma and the ionized elemental tags are then analyzed by means of time-of-flight mass spectrometry. Benefits of the mass cytometry approach are in no need for compensation, the high number of detection channels (up to 100) and low background noise. In this work, we applied a biotinylated aptamer against human PTK7 receptor for characterization of positive (human acute lymphoblastic leukemia) and negative (human Burkitt's lymphoma) cells by a mass cytometry instrument...
March 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29556334/potential-red-flag-identification-of-colorectal-adenomas-with-wide-field-fluorescence-molecular-endoscopy
#17
Elmire Hartmans, Jolien J J Tjalma, Matthijs D Linssen, Pilar Beatriz Garcia Allende, Marjory Koller, Annelies Jorritsma-Smit, Mariana E Silva de Oliveira Nery, Sjoerd G Elias, Arend Karrenbeld, Elisabeth G E de Vries, Jan H Kleibeuker, Gooitzen M van Dam, Dominic J Robinson, Vasilis Ntziachristos, Wouter B Nagengast
Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated adenomas / polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch syndrome. Detection rates may be improved by fluorescence molecular endoscopy (FME), which allows morphological visualization of lesions with high-definition white-light imaging as well as fluorescence-guided identification of lesions with a specific molecular marker. In a clinical proof-of-principal study, we investigated FME for colorectal adenoma detection, using a fluorescently labelled antibody (bevacizumab-800CW) against vascular endothelial growth factor A (VEGFA), which is highly upregulated in colorectal adenomas...
2018: Theranostics
https://www.readbyqxmd.com/read/29538683/a-randomized-double-blind-placebo-controlled-parallel-group-pilot-study-of-cannabidiol-rich-botanical-extract-in-the-symptomatic-treatment-of-ulcerative-colitis
#18
Peter M Irving, Tariq Iqbal, Chuka Nwokolo, Sreedhar Subramanian, Stuart Bloom, Neeraj Prasad, Ailsa Hart, Charles Murray, James O Lindsay, Adam Taylor, Rachel Barron, Stephen Wright
Background: Cannabidiol (CBD) exhibits anti-inflammatory properties that could improve disease activity in inflammatory bowel disease. This proof-of-concept study assessed efficacy, safety and tolerability of CBD-rich botanical extract in ulcerative colitis (UC) patients. Methods: Patients aged 18 years or older, with left-sided or extensive UC, Mayo scores of 4-10 (endoscopy scores ≥1), and on stable 5-aminosalicylic acid dosing, were randomized to 10-weeks' CBD-rich botanical extract or placebo capsules...
March 10, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29507297/broadband-multiresonator-quantum-memory-interface
#19
S A Moiseev, K I Gerasimov, R R Latypov, N S Perminov, K V Petrovnin, O N Sherstyukov
In this paper we experimentally demonstrated a broadband scheme of the multiresonator quantum memory-interface. The microwave photonic scheme consists of the system of mini-resonators strongly interacting with a common broadband resonator coupled with the external waveguide. We have implemented the impedance matched quantum storage in this scheme via controllable tuning of the mini-resonator frequencies and coupling of the common resonator with the external waveguide. Proof-of-principal experiment has been demonstrated for broadband microwave pulses when the quantum efficiency of 16...
March 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29498853/ultrafast-reactive-quantum-dynamics-coupled-to-classical-solvent-dynamics-using-an-ehrenfest-approach
#20
Julius P P Zauleck, Martin T Peschel, Florian Rott, Sebastian Thallmair, Regina de Vivie-Riedle
The inclusion of solvent effects in the theoretical analysis of molecular processes becomes increasingly important. Currently, it is not feasible to directly include the solvent on the quantum level. We use an Ehrenfest approach to study the coupled time evolution of quantum dynamically treated solutes and classical solvents system. The classical dynamics of the solvent is coupled to the wavepacket dynamics of the solute and rotational and translational degrees of freedom of the solute are included classically...
March 22, 2018: Journal of Physical Chemistry. A
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