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Yasutsugu Yukawa, Fumihiko Kato, Kota Suda, Masatsune Yamagata, Takayoshi Ueta, Munehito Yoshida
PURPOSE: This study aims to establish normative data for parameters of spino-pelvic and spinal sagittal alignment, gender related differences and age-related changes in asymptomatic subjects. METHODS: A total of 626 asymptomatic volunteers from Japanese population were enrolled in this study, including 50 subjects at least for each gender and each decade from 3rd to 8th. Full length, free-standing spine radiographs were obtained. Cervical lordosis (CL; C3-7), thoracic kyphosis (TK; T1-12), lumbar lordosis (LL; T12-S1), pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS) and sagittal vertical axis (SVA) were measured...
October 22, 2016: European Spine Journal
Tao Ye, Xi Jiang, Dongyang Wan, Xingzhi Wang, Jun Xing, Thirumalai Venkatesan, Qihua Xiong, Seeram Ramakrishna
Aligned and flexible electrospun carbon nanomaterials are used to synthesize novel carbon perovskite nanocomposite for the first time. The free electron diffusion length in CH3NH3PbI3 phase of the CH3NH3PbI3/carbon nanocomposite is observed to almost double that of bare CH3NH3PbI3 and nearly 95% of the photogenerated free holes can inject from CH3NH3PbI3 phase to the carbon nanomaterials. Furthermore, the exciton binding energy in the composite is estimated to be ~23 meV by utilizing temperature dependent optical absorption spectroscopy...
October 22, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Atsushi Imaizumi, Kunihiro Ishida, Osamu Nishizeki
BACKGROUND: Recent advancements in computed tomography have enabled the diagnosis of naso-orbito-ethmoid (NOE) fractures to be made in much greater detail. Surgical access to the upper nasofrontal buttress in NOE fractures, however, has remained unchanged over the past decades. All approaches to these fractures using skin incisions have individual drawbacks. The transcaruncular approach is free of the drawbacks of the cutaneous approaches. We further extended the transcaruncular approach for the treatment of NOE and Le Fort II fractures...
September 23, 2016: Journal of Cranio-maxillo-facial Surgery
C Jason Wang, Skye H Cheng, Jen-You Wu, Yi-Ping Lin, Wen-Hsin Kao, Chia-Li Lin, Yin-Jou Chen, Shu-Ling Tsai, Feng-Yu Kao, Andrew T Huang
Importance: Value-driven payment system reform is a potential tool for aligning economic incentives with the improvement of quality and efficiency of health care and containment of cost. Such a payment system has not been researched satisfactorily in full-cycle cancer care. Objective: To examine the association of outcomes and medical expenditures with a bundled-payment pay-for-performance program for breast cancer in Taiwan compared with a fee-for-service (FFS) program...
October 20, 2016: JAMA Oncology
Marcello Marelli, Claudio Evangelisti, Maria Vittoria Diamanti, Vladimiro Dal Santo, Mariapia Pedeferri, Claudia Letizia Bianchi, Luca Schiavi, Alberto Strini
A new protocol to synthesize size-controlled Au nanoparticles (NPs) loaded onto vertically aligned anatase TiO2 nanotubes arrays (TNTAs) prepared by electrochemical anodization is reported. Ligand-free Au NPs (< 10 nm) were deposited onto anatase TNTAs supports, finely tuning the Au loading by controlling the immersion time of the support into metal vapor synthesis (MVS)-derived Au-acetone solutions. The Au/TNTAs composites were characterized by electron microscopies (SEM, (S)TEM), X-ray diffraction, X-ray photoelectron spectroscopy and UV-Vis spectroscopy...
October 21, 2016: ACS Applied Materials & Interfaces
Matthias Lehmann, Philipp Maier, Matthias Grüne, Markus Hügel
The molecular design of crowded hexasubstituted star mesogens based on a benzene core and alternating substitution with oligo(phenylenevinylene) arms and aryl units generates free space between the conjugated arm scaffolds. Various arylcarboxy building blocks, decorated with alkoxy chains have been incorporated in the void by mixing, hydrogen bonding or covalent bonds to the aryl groups. The mesogens assemble in columnar stacks ranging from soft crystals to rectangular and hexagonal columnar liquid crystals, revealed by polarized optical microscopy, differential scanning calorimetry, X-ray scattering and modelling...
October 20, 2016: Chemistry: a European Journal
Lars Hahn, Chris-André Leimeister, Rachid Ounit, Stefano Lonardi, Burkhard Morgenstern
Many algorithms for sequence analysis rely on word matching or word statistics. Often, these approaches can be improved if binary patterns representing match and don't-care positions are used as a filter, such that only those positions of words are considered that correspond to the match positions of the patterns. The performance of these approaches, however, depends on the underlying patterns. Herein, we show that the overlap complexity of a pattern set that was introduced by Ilie and Ilie is closely related to the variance of the number of matches between two evolutionarily related sequences with respect to this pattern set...
October 2016: PLoS Computational Biology
Jie Zhou, Pianyu Zhong, Tinghui Zhang
Determination of sequence similarity is one of the major steps in computational phylogenetic studies. One of the major tasks of computational biologists is to develop novel mathematical descriptors for similarity analysis. DNA clustering is an important technology that automatically identifies inherent relationships among large-scale DNA sequences. The comparison between the DNA sequences of different species helps determine phylogenetic relationships among species. Alignment-free approaches have continuously gained interest in various sequence analysis applications such as phylogenetic inference and metagenomic classification/clustering, particularly for large-scale sequence datasets...
2016: Evolutionary Bioinformatics Online
Dong Jin Lee, G Mohan Kumar, P Ilanchezhiyan, Jae-Chul Lee, Sung Ryong Ryu, Tae Won Kang
Nowadays, solid-state inorganic-organic hybrid solar cells based on one-dimensional (1D) inorganic semiconducting nanostructures and organic polymers are believed to offer convincing solutions for the realm of next generation solar cells. In this regard, 1D ZnCdS nanowire (NW) arrays were fabricated on transparent conducting substrates through a catalyst free co-evaporation method and their wurtzite structural characteristics, 1D morphological layout and valence state/composition were studied in detail using X-ray diffraction, high-resolution electron microscopy and X-ray photoelectron spectroscopy, respectively...
October 5, 2016: Journal of Colloid and Interface Science
Go Hamasaka, Tsubasa Muto, Yoshimichi Andoh, Kazushi Fujimoto, Kenich Kato, Masaki Tanaka, Susumu Okazaki, Yasuhiro Uozumi
Wide-angle X-ray scattering experiments and all-atomistic molecular dynamics calculations were performed to elucidate the detailed structure of bilayer vesicles constructed by self-assembly of an amphiphilic palladium NCN-pincer complex. We found an excellent agreement between the experimental and calculated X-ray spectra and between the membrane thickness determined from a TEM image and that calculated from an electron-density profile, indicating that the calculated structure was highly reliable. The analysis of the simulated bilayer structure showed that the membrane was softer than other phospholipid bilayer membranes in general...
October 13, 2016: Chemistry: a European Journal
Soohyung Park, Junkyeong Jeong, Gyeongho Hyun, Minju Kim, Hyunbok Lee, Yeonjin Yi
The energy level alignments at donor/acceptor interfaces in organic photovoltaics (OPVs) play a decisive role in device performance. However, little is known about the interfacial energetics in polymer OPVs due to technical issues of the solution process. Here, the frontier ortbial line-ups at the donor/acceptor interface in high performance polymer OPVs, PTB7/PC71BM, were investigated using in situ UPS, XPS and IPES. The evolution of energy levels during PTB7/PC71BM interface formation was investigated using vacuum electrospray deposition, and was compared with that of P3HT/PC61BM...
October 13, 2016: Scientific Reports
Yin-Ting Yeh, Yi Tang, Aswathy Sebastian, Archi Dasgupta, Nestor Perea-Lopez, Istvan Albert, Huaguang Lu, Mauricio Terrones, Si-Yang Zheng
Viral infectious diseases can erupt unpredictably, spread rapidly, and ravage mass populations. Although established methods, such as polymerase chain reaction, virus isolation, and next-generation sequencing have been used to detect viruses, field samples with low virus count pose major challenges in virus surveillance and discovery. We report a unique carbon nanotube size-tunable enrichment microdevice (CNT-STEM) that efficiently enriches and concentrates viruses collected from field samples. The channel sidewall in the microdevice was made by growing arrays of vertically aligned nitrogen-doped multiwalled CNTs, where the intertubular distance between CNTs could be engineered in the range of 17 to 325 nm to accurately match the size of different viruses...
October 2016: Science Advances
W J Yang, Z Yu, R Lyu, Z J Li, H Li, W J Xiong, S H Yi, W Liu, L G Qiu
Objective: To investigate the IGHV mutational status and its differences from Caucasian in splenic marginal zone lymphoma (SMZL). Methods: A retrospective study on 40 SMZL cases were performed to detect the V-D-J sequence of IGHV by plasmid cloning sequencing, comparing the data with the most homologous germ line V sequence in database, identifying the stereotype of patients through cluster analysis and alignment. The clinical and laboratory characteristics were compared between the patients with IGHV mutation and without mutations...
September 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
John F Kelly
BACKGROUND: Alcoholics Anonymous (AA) is a world-wide recovery mutual-help organization that continues to arouse controversy. In large part, concerns persist because of AA's ostensibly quasi-religious/spiritual orientation and emphasis. In 1990 the United States' Institute of Medicine called for more studies on AA's effectiveness and its mechanisms of behavior change (MOBC) stimulating a flurry of federally funded research. This paper reviews the religious/spiritual origins of AA and its program and contrasts its theory with findings from this latest research...
October 8, 2016: Addiction
Justin T Stimatze, David A Egolf, Jeffrey S Urbach
We report the results of simulations of suspensions of sheared rigid rods in the presence of strong attractive inter-particle interactions, using dissipative particle dynamics for a coarse-grained representation of the suspending fluid. We find that the combined effect of the attractive interactions and shear-induced alignment generically produces aggregates of aligned bundles when the contact points between rods are free to rotate. However, the introduction of substantial torsional stiffness to the inter-particle contacts recapitulates the disordered aggregates often observed in suspensions of high aspect ratio particles...
September 20, 2016: Soft Matter
Mohamed A Mezour, Rachelle M Choueiri, Olena Lukoyanova, R Bruce Lennox, Dmitrii F Perepichka
The adsorption of C60-malonic derivatives C61(CO2H)2 and C66(CO2H)12 on Au(111) and a pentafluorobenzenethiol-modified Au substrate (PFBT@Au) has been investigated using scanning tunneling microscopy (STM) at a liquid-solid interface. Monofunctionalized C61(CO2H)2 forms a hexagonal close-packed overlayer on Au(111) and individual aligned dimers on PFBT@Au(111). The difference is attributed to the nature of the substrateC61(CO2H)2 interaction (isotropic π-Au bonding vs. anisotropic PFBTCOOH interactions). Surprisingly, in both cases, the directionality of the COOHCOOH motif is compromised in favor of synergistic van der Waals/H bonding interactions...
September 29, 2016: Nanoscale
C Wyatt Shields Iv, Jeffrey L Wang, Korine A Ohiri, Eric D Essoyan, Benjamin B Yellen, Andrew J Armstrong, Gabriel P López
Liquid biopsies hold enormous promise for the next generation of medical diagnoses. At the forefront of this effort, many are seeking to capture, enumerate and analyze circulating tumor cells (CTCs) as a means to prognosticate and develop individualized treatments for cancer. Capturing these rare cells, however, represents a major engineering challenge due to their low abundance, morphology and heterogeneity. A variety of microfluidic tools have been developed to isolate CTCs from drawn blood samples; however, few of these approaches offer a means to separate and analyze cells in an integrated system...
September 21, 2016: Lab on a Chip
S Srivastava, S B Lal, D C Mishra, U B Angadi, K K Chaturvedi, S N Rai, A Rai
BACKGROUND: Protein structure comparison play important role in in silico functional prediction of a new protein. It is also used for understanding the evolutionary relationships among proteins. A variety of methods have been proposed in literature for comparing protein structures but they have their own limitations in terms of accuracy and complexity with respect to computational time and space. There is a need to improve the computational complexity in comparison/alignment of proteins through incorporation of important biological and structural properties in the existing techniques...
2016: Algorithms for Molecular Biology: AMB
Jian Zhao, Xiaofeng Song, Kai Wang
RNA-Seq based transcriptome assembly has been widely used to identify novel lncRNAs. However, the best-performing transcript reconstruction methods merely identified 21% of full-length protein-coding transcripts from H. sapiens. Those partial-length protein-coding transcripts are more likely to be classified as lncRNAs due to their incomplete CDS, leading to higher false positive rate for lncRNA identification. Furthermore, potential sequencing or assembly error that gain or abolish stop codons also complicates ORF-based prediction of lncRNAs...
October 6, 2016: Scientific Reports
Clara L Garcia-Rodenas, Michael Affolter, Gerard Vinyes-Pares, Carlos A De Castro, Leonidas G Karagounis, Yumei Zhang, Peiyu Wang, Sagar K Thakkar
Human breast milk (BM) amino acid (AA) composition may be impacted by lactation stage or factors related to geographical location. The present cross-sectional study is aimed at assessing the temporal changes of BMAA over lactation stages in a large cohort of urban mothers in China. Four hundred fifty BM samples, collected in three Chinese cities covering eight months of lactation were analyzed for free (FAA) and total (TAA) AA by o-phthalaldehyde/ fluorenylmethylchloroformate (OPA/FMOC) derivatization. Concentrations and changes over lactation were aligned with previous reports...
2016: Nutrients
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