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https://www.readbyqxmd.com/read/28823088/electrical-signals-triggered-controllable-formation-of-calcium-alginate-film-for-wound-treatment
#1
Xiaoli Liu, Huan Liu, Xue Qu, Miao Lei, Chuchu Zhang, Hua Hong, Gregory F Payne, Changsheng Liu
Wound dressings play important roles in the management of wounds, and calcium cross-linked alginate (Ca(2+)-Alg) is a commonly used hydrogel that is adapted for wound treatment. However, conventional methods for fabricating Ca(2+)-Alg hydrogels can be tedious and difficult to control because of the rapid Ca(2+)-induced gelation of alginate. In this study, An electrodeposition method was used to rapidly and controllably fabricate Ca(2+)-Alg films for wound treatment. Several measures of film growth (e.g., thickness and mass) are shown to linearly correlate to the imposed charge transfer at the electrode...
August 19, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28820213/chip-scale-alignment-of-long-dna-nanofibers-on-a-patterned-self-assembled-monolayer
#2
J Xia, M Su
Controlled alignment of long DNA nanofibers is challenging. This communication reports a method to align human genomic DNA with nearly unlimited length using lithographically produced micro-patterns of self-assembled monolayers (SAMs) with positively charged terminal groups. The micro-patterns act as local DNA reservoirs to supply DNAs for nanofiber formation, and can also stretch and align DNA nanofibers to form an ordered array by controlling the dewetting profile. By reducing the size and inter-patch distance of a micro-patch, a nearly uniform array of long DNA nanofibers can be patterned over a large area...
August 18, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28819756/nanofibers-grafted-on-titanium-alloy-the-effects-of-fiber-alignment-and-density-on-osteoblast-mineralization
#3
Hsin-Yi Lin, Zhao-Xiang Peng
The surface of medical implant alloy Ti-6Al-4V was chemically modified to allow it to covalently bond with collagen/PVA nanofibers. These nanofibers were successfully attached to the Ti-6Al-4V surface in three different morphologies: randomly oriented high-density fiber, COL(H); randomly oriented low-density fiber, COL(L); and aligned high-density fiber, COL(A). The effects of the morphology of these covalently-bound collagen nanofibers on the growth and differentiation of osteoblasts were studied for 21 days...
August 17, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28814765/electric-field-induced-alignment-of-electrically-neutral-disk-like-particles-modelling-and-calculation
#4
Rongshan Qin
This work reveals a torque from electric field to electrically neutral flakes that are suspended in a higher electrical conductive matrix. The torque tends to rotate the particles toward an orientation with its long axis parallel to the electric current flow. The alignment enables the anisotropic properties of tiny particles to integrate together and generate desirable macroscale anisotropic properties. The torque was obtained from thermodynamic calculation of electric current free energy at various microstructure configurations...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813860/design-and-evaluation-of-a-modular-lower-limb-exoskeleton-for-rehabilitation
#5
Wilian M Dos Santos, Samuel L Nogueira, Gustavo C de Oliveira, Guido G Pena, Adriano A G Siqueira
This paper deals with the evaluation of an exoskeleton designed for assisting individuals to rehabilitate compromised lower limb movements resulting from stroke or incomplete spinal cord injury. The exoskeleton is composed of lightweight tubular structures and six free joints that provide a modular feature to the system. This feature allows the exoskeleton to be adapted to assist the movement of one or more patient joints. The actuation of the exoskeleton is also modular, and can be performed passively, by means of springs and dampers, or actively through actuators...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28809889/two-stage-cross-talk-mitigation-in-an-orbital-angular-momentum-based-free-space-optical-communication-system
#6
Zhen Qu, Ivan B Djordjevic
We propose and experimentally demonstrate a two-stage cross-talk mitigation method in an orbital-angular-momentum (OAM)-based free-space optical communication system, which is enabled by combining spatial offset and low-density parity-check (LDPC) coded nonuniform signaling. Different from traditional OAM multiplexing, where the OAM modes are centrally aligned for copropagation, the adjacent OAM modes (OAM states 2 and -6 and OAM states -2 and 6) in our proposed scheme are spatially offset to mitigate the mode cross talk...
August 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28806711/the-potential-of-an-automated-system-to-identify-the-upper-limb-component-of-a-controlled-sitting-posture
#7
María B Sánchez, Ian Loram, John Darby, Paul Holmes, Penelope B Butler
Full trunk control in sitting is demonstrated only when the head-trunk are aligned and upper limbs remain free of contact from mechanical support. These components represent a Controlled Kinetic Chain and can be evaluated in people with neuromotor disability using the Segmental Assessment of Trunk Control (SATCo) when a therapist provides manual trunk support at different segmental levels. However, the SATCo, as with other clinical assessments of control, is subjective. The SATCo was translated to objective rules relating the position of the hands and elbows to the head-trunk and then tested to determine the extent to which this automated objective method replicated the clinical judgement...
August 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28797754/fabrication-of-metal-free-two-dimensional-two-dimensional-homojunction-photocatalyst-using-various-carbon-nitride-nanosheets-as-building-blocks
#8
Boyong Ye, Xiaoxue Han, Mengdie Yan, Huanhuan Zhang, Fengna Xi, Xiaoping Dong, Jiyang Liu
Semiconductor photocatalysis currently suffered three main problems, low solar energy utilization, high photo-generated charge recombination rate and the heavy metal ions release by the photo-corrosion. Herein, we developed a visible-light-driven homojunction photocatalyst with the metal-free two-dimensional (2D) graphitic carbon nitride nanosheets (CNNS). By employing liquid exfoliation and chemical blowing approaches, we obtained two kinds of CNNS materials (le-CNNS and cb-CNNS) with different band structures, and subsequently fabricated the homojunction photocatalyst...
August 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28795778/time-dependent-effect-of-electrical-stimulation-on-osteogenic-differentiation-of-bone-mesenchymal-stromal-cells-cultured-on-conductive-nanofibers
#9
Siqi Zhu, Wei Jing, Xiaoqing Hu, Zirong Huang, Qing Cai, Yingfang Ao, Xiaoping Yang
Bone tissue engineering using bone mesenchymal stromal cells (BMSCs) is a multidisciplinary strategy that requires biodegradable scaffold, cell, various promoting cues to work simultaneously. Electrical stimulation (ES) is known able to promote osteogenic differentiation of BMSCs, but it is interesting to know how can it play the strongest promotion effect. To strengthen local ES on BMSCs, parallel-aligned conductive nanofibers were electrospun from the mixtures of poly(L-lactide) (PLLA) and multi-walled carbon nanotubes (MWCNTs), and used for cell culture...
August 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28791135/local-interactions-and-global-properties-of-wild-free-ranging-stickleback-shoals
#10
Ashley J W Ward, Timothy M Schaerf, James E Herbert-Read, Lesley Morrell, David J T Sumpter, Mike M Webster
Collective motion describes the global properties of moving groups of animals and the self-organized, coordinated patterns of individual behaviour that produce them. We examined the group-level patterns and local interactions between individuals in wild, free-ranging shoals of three-spine sticklebacks, Gasterosteus aculeatus. Our data reveal that the highest frequencies of near-neighbour encounters occur at between one and two body lengths from a focal fish, with the peak frequency alongside a focal individual...
July 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28782923/fully-packaged-carbon-nanotube-supercapacitors-by-direct-ink-writing-on-flexible-substrates
#11
Bolin Chen, Yizhou Jiang, Xiaohui Tang, Yayue Pan, Shan Hu
The ability to print fully packaged integrated energy storage components (e.g., supercapacitors) is of critical importance for practical applications of printed electronics. Due to the limited variety of printable materials, most studies on printed supercapacitors focus on printing the electrode materials but rarely the full-packaged cell. This work presents for the first time the printing of a fully packaged single-wall carbon nanotube-based supercapacitor with direct ink writing (DIW) technology. Enabled by the developed ink formula, DIW setup, and cell architecture, the whole printing process is mask free, transfer free, and alignment free with precise and repeatable control on the spatial distribution of all constituent materials...
August 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28777613/coherent-radiative-decay-of-molecular-rotations-a-comparative-study-of-terahertz-oriented-versus-optically-aligned-molecular-ensembles
#12
Ran Damari, Dina Rosenberg, Sharly Fleischer
The decay of field-free rotational dynamics is experimentally studied by two complementary methods: laser-induced molecular alignment and terahertz-field-induced molecular orientation. A comparison between the decay rates of different molecular species at various gas pressures reveals that oriented molecular ensembles decay faster than aligned ensembles. The discrepancy in decay rates is attributed to the coherent radiation emitted by the transiently oriented ensembles and is absent from aligned molecules. The experimental results reveal the dramatic contribution of coherent radiative emission to the observed decay of rotational dynamics and underline a general phenomenon expected whenever field-free coherent dipole oscillations are induced...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28775337/femur-first-navigation-can-reduce-impingement-severity-compared-to-traditional-free-hand-total-hip-arthroplasty
#13
Arnab Palit, Mark A Williams, Glen A Turley, Tobias Renkawitz, Markus Weber
Impingement is a major source of dislocation and aseptic loosening in total hip arthroplasty (THA). We compared impingement free range of motion (ROM) using a novel computer navigated femur first approach to conventional THA. In addition, impingement between genders was also explored. In a retrospective analysis of 121 THA patients, subject-specific post-operative ROM was simulated using post-operative 3D-CT data, and compared with the benchmark ROM, essential for activities of daily living. Three parameters were defined to express both implant-to-implant (ITI) and bone-to-bone (BTB) impingement - coverage percentage, third angle, and impingement severity...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28770045/semi-supervised-determination-of-pseudocryptic-morphotypes-using-observer-free-characterizations-of-anatomical-alignment-and-shape
#14
Natasha S Vitek, Carly L Manz, Tingran Gao, Jonathan I Bloch, Suzanne G Strait, Doug M Boyer
Accurate, quantitative characterization of complex shapes is recognized as a key methodological challenge in biology. Recent development of automated three-dimensional geometric morphometric protocols (auto3dgm) provides a promising set of tools to help address this challenge. While auto3dgm has been shown to be useful in characterizing variation across clades of morphologically very distinct mammals, it has not been adequately tested in more problematic cases where pseudolandmark placement error potentially confounds interpretation of true shape variation...
July 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28768101/dependence-of-binding-free-energies-between-rna-nucleobases-and-protein-side-chains-on-local-dielectric-properties
#15
Anita de Ruiter, Anton A Polyansky, Bojan Zagrovic
In order to fully understand the microscopic origins of binding specificity between nucleic acids and proteins, it is imperative to study the dependence of the binding preferences between nucleobases and protein side chains on the properties of the environment. Here, we employ molecular dynamics simulations and umbrella sampling to derive the potentials of mean force and the associated absolute binding free energies between the four standard RNA nucleobases and the side chains of aspartic acid and tryptophan in water/methanol mixtures exhibiting a wide range of dielectric constants...
August 16, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28767495/making-the-first-cut-an-analysis-of-academic-medicine-editors-reasons-for-not-sending-manuscripts-out-for-external-peer-review
#16
Holly S Meyer, Steven J Durning, David Sklar, Lauren A Maggio
PURPOSE: Manuscripts submitted to Academic Medicine (AM) undergo an internal editor review to determine whether they will be sent for external peer review. Increasingly, manuscripts are rejected at this early stage. This study seeks to inform scholars about common reasons for internal editor review rejections, increase transparency of the process, and provide suggestions for improving submissions. METHOD: A mixed-methods approach was used to retrospectively analyze editors' free-text comments...
August 1, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28767218/selective-binders-of-the-tandem-sh2-domains-in-syk-and-zap-70-kinases-by-dna-programmed-spatial-screening
#17
Michaela Marczynke, Katharina Groeger, Oliver Seitz
Members of the Syk family of tyrosine kinases arrange Src homology 2 (SH2) domains in tandem to allow firm binding of immunoreceptor tyrosine-based interaction motifs (ITAMs). While the advantages provided by the bivalency enhanced interactions are evident, the impact on binding specificity is less clear. For example, the Spleen tyrosine kinase (Syk) and the Zeta-chain-associated protein kinase (ZAP-70) recognize the consensus sequence pYXXI/L(X)6-8 pYXXI/L with near identical nanomolar affinity. The non-discriminatory recognition on the one hand poses a specificity challenge for the design of sub-type selective protein binders and, on the other hand, raises the question as to how differential activation of Syk and ZAP-70 is ensured when both kinases are co-expressed...
August 2, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28766097/ranking-docking-poses-by-graph-matching-of-protein-ligand-interactions-lessons-learned-from-the-d3r-grand-challenge-2
#18
Priscila da Silva Figueiredo Celestino Gomes, Franck Da Silva, Guillaume Bret, Didier Rognan
A novel docking challenge has been set by the Drug Design Data Resource (D3R) in order to predict the pose and affinity ranking of a set of Farnesoid X receptor (FXR) agonists, prior to the public release of their bound X-ray structures and potencies. In a first phase, 36 agonists were docked to 26 Protein Data Bank (PDB) structures of the FXR receptor, and next rescored using the in-house developed GRIM method. GRIM aligns protein-ligand interaction patterns of docked poses to those of available PDB templates for the target protein, and rescore poses by a graph matching method...
August 1, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28763623/the-effects-of-anterolateral-tenodesis-on-tibiofemoral-contact-pressures-and-kinematics
#19
Eivind Inderhaug, Joanna M Stephen, Hadi El-Daou, Andy Williams, Andrew A Amis
BACKGROUND: Anterolateral tenodeses are increasingly popular in combination with intra-articular anterior cruciate ligament reconstructions. Despite the perception of risk of overconstraint and lateral osteoarthritis, evidence is lacking regarding the effect of graft tensioning on knee kinematics and intra-articular compartmental joint pressures. PURPOSE: To investigate tibiofemoral joint contact pressures and kinematics related to an anterolateral lesion and the effectiveness of a MacIntosh tenodesis in restoring these when varying (1) graft tension and (2) tibial rotation during graft fixation...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28758724/enhanced-oxygen-evolution-reaction-electrocatalysis-via-electrodeposited-amorphous-%C3%AE-phase-nickel-cobalt-hydroxide-nanodendrite-forests
#20
Anirudh Balram, Hanfei Zhang, Sunand Santhanagopalan
We demonstrate an electrodeposition method to rapidly grow novel three-dimensional (3-D) nanodendrite forests of amorphous α-phase mixed nickel-cobalt hydroxides on stainless steel foil toward high performance electrocatalysis of the oxygen evolution reaction (OER). The proposed hydrogen bubble-templated, diffusion-limited deposition process leads to the unprecedented dendritic growth of vertically-aligned amorphous metal hydroxides, induced by the controlled electrolysis of the tuned water content in the primarily alcohol-based deposition solution...
July 31, 2017: ACS Applied Materials & Interfaces
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