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christobel saunders

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https://www.readbyqxmd.com/read/29599518/psychological-outcomes-and-surgical-decisions-after-genetic-testing-in-women-newly-diagnosed-with-breast-cancer-with-and-without-a-family-history
#1
Bettina Meiser, Veronica F Quinn, Gillian Mitchell, Kathy Tucker, Kaaren J Watts, Belinda Rahman, Michelle Peate, Christobel Saunders, Elizabeth Geelhoed, Margaret Gleeson, Kristine Barlow-Stewart, Michael Field, Marion Harris, Yoland C Antill, Rachel Susman, Michael T Bowen, Llew Mills, Judy Kirk
In patients with early breast cancer, personal and tumour characteristics other than family history are increasingly used to prompt genetic testing to guide women's cancer management (treatment-focused genetic testing, 'TFGT'). Women without a known strong family history of breast and/or ovarian may be more vulnerable to psychological sequelae arising from TFGT. We compared the impact of TFGT in women with (FH+) and without (FH-) a strong family history on psychological adjustment and surgical decisions. Women aged <50 years with high-risk features were offered TFGT before definitive breast cancer surgery and completed self-report questionnaires at four time points over 12 months...
March 30, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29541505/wide-field-quantitative-micro-elastography-of-human-breast-tissue
#2
Wes M Allen, Kelsey M Kennedy, Qi Fang, Lixin Chin, Andrea Curatolo, Lucinda Watts, Renate Zilkens, Synn Lynn Chin, Benjamin F Dessauvagie, Bruce Latham, Christobel M Saunders, Brendan F Kennedy
Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing a mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes...
March 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29449676/the-improving-rural-cancer-outcomes-trial-a-cluster-randomised-controlled-trial-of-a-complex-intervention-to-reduce-time-to-diagnosis-in-rural-cancer-patients-in-western-australia
#3
Jon D Emery, Victoria Gray, Fiona M Walter, Shelley Cheetham, Emma J Croager, Terry Slevin, Christobel Saunders, Timothy Threlfall, Kirsten Auret, Anna K Nowak, Elizabeth Geelhoed, Max Bulsara, C D'Arcy J Holman
This corrects the article DOI: 10.1038/bjc.2017.310.
February 15, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29392828/arm-morbidity-of-axillary-dissection-with-sentinel-node-biopsy-versus-delayed-axillary-dissection
#4
Helen Ballal, Catherine Hunt, Chrianna Bharat, Kevin Murray, Roshi Kamyab, Christobel Saunders
BACKGROUND: Staging of axillary lymph nodes in breast cancer is important for prognostication and planning of adjuvant therapy. The traditional practice of proceeding to axillary lymph node dissection (ALND) if sentinel lymph node biopsy (SLNB) is positive is being challenged and clinical trials are underway. For many centres, this will mean a move away from intra-operative SLNB assessment and utilization of a second procedure to perform ALND. It is sometimes perceived that a delayed ALND results in increased tissue damage and thus increased morbidity...
February 2, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29288572/label-free-optical-imaging-technologies-for-rapid-translation-and-use-during-intraoperative-surgical-and-tumor-margin-assessment
#5
Stephen A Boppart, J Quincy Brown, Camile S Farah, Esther Kho, Laura Marcu, Christobel M Saunders, Henricus J C M Sterenborg
The biannual International Conference on Biophotonics was recently held on April 30 to May 1, 2017, in Fremantle, Western Australia. This continuing conference series brought together key opinion leaders in biophotonics to present their latest results and, importantly, to participate in discussions on the future of the field and what opportunities exist when we collectively work together for using biophotonics for biological discovery and medical applications. One session in this conference, entitled "Tumor Margin Identification: Critiquing Technologies," challenged invited speakers and attendees to review and critique representative label-free optical imaging technologies and their application for intraoperative assessment and guidance in surgical oncology...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29102440/patient-satisfaction-with-radioguided-occult-lesion-localisation-using-iodine-125-seeds-rollis-versus-conventional-hookwire-localisation
#6
RANDOMIZED CONTROLLED TRIAL
Jeremy S L Ong, Joelin Teh, Christobel Saunders, Anita G Bourke, Catalina Lizama, Jade Newton, Michael Phillips, Donna B Taylor
BACKGROUND: Women with impalpable or poorly palpable breast cancer require radiologically guided localisation prior to breast conserving surgery. Radioguided Occult Lesion Localisation using Iodine-125 Seed (ROLLIS) is an emerging alternative to conventional Hookwire Localisation (HWL). We compared ROLLIS with conventional HWL with respect to patient reported stress and discomfort related to the localisation procedure. PATIENTS AND METHODS: From September 2013 to January 2016, women who were eligible for breast conserving surgery with impalpable or poorly palpable histologically confirmed invasive or in-situ carcinoma were recruited to the multi-centre ROLLIS randomised controlled trial and underwent either ROLLIS or HWL...
December 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28945295/perceived-influence-of-psychological-consultation-on-psychological-well-being-body-image-and-intimacy-following-bilateral-prophylactic-mastectomy-a-qualitative-analysis
#7
Rachael Glassey, Sarah J Hardcastle, Moira O'Connor, Angela Ives, Christobel Saunders
OBJECTIVE: This study explored whether psychological consultation offered to women prior to bilateral prophylactic mastectomy (BPM) appeared to provide psychosocial benefit to younger women (<35 years) at high risk of developing breast cancer due to a mutation or family history. METHODS: Qualitative interviews guided by interpretative phenomenological analysis were conducted retrospectively with 26 women who had undergone BPM. Participants were recruited from New Zealand and Australia, via a genetics clinic, registry, research cohort, and online...
September 25, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28926528/the-improving-rural-cancer-outcomes-trial-a-cluster-randomised-controlled-trial-of-a-complex-intervention-to-reduce-time-to-diagnosis-in-rural-cancer-patients-in-western-australia
#8
RANDOMIZED CONTROLLED TRIAL
Jon D Emery, Victoria Gray, Fiona M Walter, Shelley Cheetham, Emma J Croager, Terry Slevin, Christobel Saunders, Timothy Threlfall, Kirsten Auret, Anna K Nowak, Elizabeth Geelhoed, Max Bulsara, C D'Arcy J Holman
BACKGROUND: Rural Australians have poorer survival for most common cancers, due partially to later diagnosis. Internationally, several initiatives to improve cancer outcomes have focused on earlier presentation to healthcare and timely diagnosis. We aimed to measure the effect of community-based symptom awareness and general practice-based educational interventions on the time to diagnosis in rural patients presenting with breast, prostate, colorectal or lung cancer in Western Australia...
November 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28883923/integrated-care-for-resected-early-stage-lung-cancer-innovations-and-exploring-patient-needs
#9
REVIEW
Jan Ho, Annette McWilliams, Jon Emery, Christobel Saunders, Christopher Reid, Suzanne Robinson, Fraser Brims
There is no consensus as to the duration and nature of follow-up following surgical resection with curative intent of lung cancer. The integration of cancer follow-up into primary care is likely to be a key future area for quality and cost-effective cancer care. Evidence from other solid cancer types demonstrates that such follow-up has no adverse outcomes, similar health-related quality of life, high patient satisfaction rates at a lower cost to the healthcare system. Core elements for successful models of shared cancer care are required: clear roles and responsibilities, timely effective communication, guidance on follow-up protocols and common treatments and rapid routes to (re)access specialist care...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28870441/influences-on-decision-making-for-young-women-undergoing-bilateral-prophylactic-mastectomy
#10
Rachael Glassey, Moira O'Connor, Angela Ives, Christobel Saunders, Sarah J Hardcastle
OBJECTIVE: The objective of this study was to explore the influences on decision-making of younger women (<35) undergoing or considering bilateral prophylactic mastectomy (BPM). METHODS: Qualitative interviews guided by interpretative phenomenological analysis (IPA) were conducted with forty-six women who had a strong family history of breast cancer (BC) who had either undergone (n=26) or were considering (n=20) BPM. Participants were recruited from Australia and New Zealand (NZ) via hospitals, a genetics clinic, a research cohort, a registry and online...
August 24, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28866282/calcium-channel-blockers-and-breast-cancer-incidence-an-updated-systematic-review-and-meta-analysis-of-the-evidence
#11
REVIEW
Cameron M Wright, Rachael E Moorin, Enayet K Chowdhury, Bruno H Stricker, Christopher M Reid, Christobel M Saunders, Jeffery D Hughes
Controversy exists regarding the potential association between taking calcium channel blockers (CCBs) and the development of breast cancer. As a positive association would have important public health implications due to the widespread use of CCBs, this study aimed to incorporate new evidence to determine whether an association is likely to exist. We searched MEDLINE, EMBASE and the Cochrane Library to 28 June 2016 for relevant literature. References and citing articles were checked and authors contacted as necessary...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28809039/juvenile-melanomas-western-australian-melanoma-advisory-service-experience
#12
Jie Xin Xu, Sharnice Koek, Samantha Lee, Mark Hanikeri, Mark Lee, Trevor Beer, Christobel Saunders
BACKGROUND/OBJECTIVES: Juvenile melanoma (before 20 years of age) is a rare condition with poorly defined risk factors. We describe features of juvenile melanoma in Western Australia over the last two decades. METHOD: A retrospective review of juvenile melanomas was conducted from prospectively maintained databases, reviewed for patients' characteristics, clinical information, histology, treatment, recurrence and survival data. RESULTS: Altogether 95 cases of juvenile melanoma were reported to the Western Australian Cancer Registry between 2000 and 2013...
August 15, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28797766/pregnancy-outcomes-after-a-breast-cancer-diagnosis-a-systematic-review-and-meta-analysis
#13
REVIEW
Brigitte Gerstl, Elizabeth Sullivan, Angela Ives, Christobel Saunders, Handan Wand, Antoinette Anazodo
Improvements in local and systemic treatment, along with earlier diagnoses through breast awareness and screening, have led to increases in survival and a decline in breast cancer (BC) recurrence. To the best of our knowledge, no meta-analysis has yet focused on pregnancy outcomes after BC treatment. Hence, our research group explored the reproductive outcomes (pregnancy, miscarriage, termination of pregnancy, live births) after BC treatment. The Embase, MEDLINE, PubMed, and Scopus databases were searched. Studies were included that reported on pregnancy and reproductive outcomes after treatment of BC...
February 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28765859/clinical-consultations-and-investigations-before-and-after-discontinuation-of-endocrine-therapy-in-women-with-primary-breast-cancer
#14
Derrick Lopez, Anna Kemp-Casey, Christobel Saunders, Elizabeth Roughead, Frances Boyle, Max Bulsara, David Preen
OBJECTIVE: Although clinical trials recommend that women with hormone-dependent primary breast cancer remain on endocrine therapy for at least 5 years, up to 60% discontinue treatment early. We determined whether these women had consulted with clinicians or had investigations for cancer recurrence or metastasis around the time they discontinued endocrine therapy, and whether clinical contact continued after discontinuation. METHODS: We performed case-control and cohort studies of women from the 45 and Up Study who were diagnosed with invasive primary breast cancer between January 2003 and December 2008, and who had ≥12 months of anastrozole, exemestane, letrozole or tamoxifen subsequently dispensed...
July 26, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28727237/pre-hydrated-sterile-acellular-dermal-matrix-allograft-in-breast-reconstruction-review-of-a-single-unit-s-experience
#15
Justin James, Brigid Corrigan, Christobel Saunders
BACKGROUND: The acellular dermal matrix (Flex HD) (FHD) became available for use in Western Australia in 2014 to aid prosthetic breast reconstruction and this descriptive study aims to review and discuss a single institution's experience since its introduction. METHODS: By retrospective case note, review data were collected for all patients who underwent prosthetic breast reconstruction with the aid of FHD between January 2014 and August 2015 in our institution...
July 20, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28528727/sexual-inactivity-in-partnered-female-cancer-survivors
#16
Jennifer L Marino, Christobel M Saunders, Martha Hickey
OBJECTIVE: To measure sexual activity in a clinic population of partnered female cancer survivors, and to better understand reasons for sexual inactivity in this population. MATERIALS AND METHODS: Partnered peri- or post-menopausal cancer survivors seen at a specialty clinic for menopause symptoms after cancer completed Fallowfield's Sexual Activity Questionnaire, quality of life measures (the Functional Assessment of Cancer Therapy General, Breast Cancer, and Endocrine Symptom Scales), and the Greene Climacteric Scale...
May 9, 2017: Maturitas
https://www.readbyqxmd.com/read/28501958/heightened-perception-of-breast-cancer-risk-in-young-women-at-risk-of-familial-breast-cancer
#17
Rachael Glassey, Moira O'Connor, Angela Ives, Christobel Saunders, Sarah O'Sullivan, Sarah J Hardcastle
The objective of this study was to explore the factors that influence perceived personal risk of developing breast cancer (BC) in younger women (<35) who are considering or have undergone bilateral prophylactic mastectomy (BPM). Qualitative interviews guided by interpretative phenomenological analysis were conducted with 46 women who had a strong family history of BC and had either undergone (n = 26) or were considering (n = 20) BPM. Participants were recruited from Australia and New Zealand via hospitals, a genetics clinic, a research cohort, a registry and online...
January 2018: Familial Cancer
https://www.readbyqxmd.com/read/28473176/managing-menopausal-symptoms-after-breast-cancer-a-multidisciplinary-approach
#18
REVIEW
Paul A Cohen, Annabelle Brennan, Jennifer L Marino, Christobel M Saunders, Martha Hickey
More than 6 million women worldwide are living with a past diagnosis of breast cancer. Most survive their illness, and management of the long-term consequences of treatment has become a priority in cancer care. Menopausal symptoms affect most breast cancer survivors and may significantly impair quality of life. We describe a multidisciplinary model to evaluate and manage these women using a patient-focused approach. The 'Multidisciplinary Menopause After Cancer Clinic' includes gynecologists, endocrinologists, GPs, a psychologist and a clinical nurse specialist...
November 2017: Maturitas
https://www.readbyqxmd.com/read/28357171/value-based-care-in-the-worldwide-battle-against-cancer
#19
REVIEW
Niloufer J Johansen, Christobel M Saunders
Globally, an increasing and aging population is contributing to the prevalence of cancer. To be effective, cancer care needs to involve the coordination of multidisciplinary specialties, and also needs to be affordable, accessible, and capable of producing optimal patient outcomes. Porter and Teisberg (2006) have postulated that shifting current healthcare strategies from volume-based to patient-centric care redirects economic competition to providing treatments which promote the best patient outcomes while driving down costs...
February 17, 2017: Curēus
https://www.readbyqxmd.com/read/28197122/commentary-bilateral-risk-reducing-mastectomy-is-the-safest-strategy-in-brca1-carriers
#20
COMMENT
Rachael Glassey, Christobel Saunders, Sarah J Hardcastle
No abstract text is available yet for this article.
2017: Frontiers in Psychology
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