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https://www.readbyqxmd.com/read/28809039/juvenile-melanomas-western-australian-melanoma-advisory-service-experience
#1
Jie Xin Xu, Sharnice Koek, Samantha Lee, Mark Hanikeri, Mark Lee, Trevor Beer, Christobel Saunders
BACKGROUND/OBJECTIVES: Juvenile melanoma (before 20 years of age) is a rare condition with poorly defined risk factors. We describe features of juvenile melanoma in Western Australia over the last two decades. METHOD: A retrospective review of juvenile melanomas was conducted from prospectively maintained databases, reviewed for patients' characteristics, clinical information, histology, treatment, recurrence and survival data. RESULTS: Altogether 95 cases of juvenile melanoma were reported to the Western Australian Cancer Registry between 2000 and 2013...
August 15, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28797766/pregnancy-outcomes-after-a-breast-cancer-diagnosis-a-systematic-review-and-meta-analysis
#2
REVIEW
Brigitte Gerstl, Elizabeth Sullivan, Angela Ives, Christobel Saunders, Handan Wand, Antoinette Anazodo
Improvements in local and systemic treatment, along with earlier diagnoses through breast awareness and screening, have led to increases in survival and a decline in breast cancer (BC) recurrence. To the best of our knowledge, no meta-analysis has yet focused on pregnancy outcomes after BC treatment. Hence, our research group explored the reproductive outcomes (pregnancy, miscarriage, termination of pregnancy, live births) after BC treatment. The Embase, MEDLINE, PubMed, and Scopus databases were searched. Studies were included that reported on pregnancy and reproductive outcomes after treatment of BC...
July 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28765859/clinical-consultations-and-investigations-before-and-after-discontinuation-of-endocrine-therapy-in-women-with-primary-breast-cancer
#3
Derrick Lopez, Anna Kemp-Casey, Christobel Saunders, Elizabeth Roughead, Frances Boyle, Max Bulsara, David Preen
OBJECTIVE: Although clinical trials recommend that women with hormone-dependent primary breast cancer remain on endocrine therapy for at least 5 years, up to 60% discontinue treatment early. We determined whether these women had consulted with clinicians or had investigations for cancer recurrence or metastasis around the time they discontinued endocrine therapy, and whether clinical contact continued after discontinuation. METHODS: We performed case-control and cohort studies of women from the 45 and Up Study who were diagnosed with invasive primary breast cancer between January 2003 and December 2008, and who had ≥12 months of anastrozole, exemestane, letrozole or tamoxifen subsequently dispensed...
July 26, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28727237/pre-hydrated-sterile-acellular-dermal-matrix-allograft-in-breast-reconstruction-review-of-a-single-unit-s-experience
#4
Justin James, Brigid Corrigan, Christobel Saunders
BACKGROUND: The acellular dermal matrix (Flex HD) (FHD) became available for use in Western Australia in 2014 to aid prosthetic breast reconstruction and this descriptive study aims to review and discuss a single institution's experience since its introduction. METHODS: By retrospective case note, review data were collected for all patients who underwent prosthetic breast reconstruction with the aid of FHD between January 2014 and August 2015 in our institution...
July 20, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28528727/sexual-inactivity-in-partnered-female-cancer-survivors
#5
Jennifer L Marino, Christobel M Saunders, Martha Hickey
OBJECTIVE: To measure sexual activity in a clinic population of partnered female cancer survivors, and to better understand reasons for sexual inactivity in this population. MATERIALS AND METHODS: Partnered peri- or post-menopausal cancer survivors seen at a specialty clinic for menopause symptoms after cancer completed Fallowfield's Sexual Activity Questionnaire, quality of life measures (the Functional Assessment of Cancer Therapy General, Breast Cancer, and Endocrine Symptom Scales), and the Greene Climacteric Scale...
May 9, 2017: Maturitas
https://www.readbyqxmd.com/read/28501958/heightened-perception-of-breast-cancer-risk-in-young-women-at-risk-of-familial-breast-cancer
#6
Rachael Glassey, Moira O'Connor, Angela Ives, Christobel Saunders, Sarah O'Sullivan, Sarah J Hardcastle
The objective of this study was to explore the factors that influence perceived personal risk of developing breast cancer (BC) in younger women (<35) who are considering or have undergone bilateral prophylactic mastectomy (BPM). Qualitative interviews guided by interpretative phenomenological analysis were conducted with 46 women who had a strong family history of BC and had either undergone (n = 26) or were considering (n = 20) BPM. Participants were recruited from Australia and New Zealand via hospitals, a genetics clinic, a research cohort, a registry and online...
May 13, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28473176/managing-menopausal-symptoms-after-breast-cancer-a-multidisciplinary-approach
#7
REVIEW
Paul A Cohen, Annabelle Brennan, Jennifer L Marino, Christobel M Saunders, Martha Hickey
More than 6 million women worldwide are living with a past diagnosis of breast cancer. Most survive their illness, and management of the long-term consequences of treatment has become a priority in cancer care. Menopausal symptoms affect most breast cancer survivors and may significantly impair quality of life. We describe a multidisciplinary model to evaluate and manage these women using a patient-focused approach. The 'Multidisciplinary Menopause After Cancer Clinic' includes gynecologists, endocrinologists, GPs, a psychologist and a clinical nurse specialist...
April 22, 2017: Maturitas
https://www.readbyqxmd.com/read/28357171/value-based-care-in-the-worldwide-battle-against-cancer
#8
REVIEW
Niloufer J Johansen, Christobel M Saunders
Globally, an increasing and aging population is contributing to the prevalence of cancer. To be effective, cancer care needs to involve the coordination of multidisciplinary specialties, and also needs to be affordable, accessible, and capable of producing optimal patient outcomes. Porter and Teisberg (2006) have postulated that shifting current healthcare strategies from volume-based to patient-centric care redirects economic competition to providing treatments which promote the best patient outcomes while driving down costs...
February 17, 2017: Curēus
https://www.readbyqxmd.com/read/28197122/commentary-bilateral-risk-reducing-mastectomy-is-the-safest-strategy-in-brca1-carriers
#9
COMMENT
Rachael Glassey, Christobel Saunders, Sarah J Hardcastle
No abstract text is available yet for this article.
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28105750/development-of-a-peer-review-framework-for-cancer-multi-disciplinary-meetings
#10
Claire E Johnson, Neli Slavova-Azmanova, Christobel Saunders
BACKGROUND: There is no mechanism in place for monitoring or quality improvement of cancer multidisciplinary meetings (MDMs) in Australia. OBJECTIVE: To develop a peer review process for quality improvement of MDMs. METHODS: This project involved three phases: 1) development of a draft peer review framework, supporting documents and peer review process; 2) consultation with key stakeholders; 3) refinement of the framework, documents and processes following a pilot study with three MDMs...
January 20, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28096010/a-pilot-study-of-routine-screening-for-distress-by-a-nurse-and-psychologist-in-an-outpatient-haematological-oncology-clinic
#11
Toni Musiello, Glenys Dixon, Moira O'Connor, Deb Cook, Lisa Miller, Anna Petterson, Christobel Saunders, David Joske, Claire Johnson
AIM: To explore the: 1) prevalence of distress, type of problems experienced by haematological patients, and referrals for supportive care; 2) effect of demographic and clinical variables on distress, and 3) effect on the time of health professionals conducting the screening in the ambulatory chemotherapy setting. METHODS: Participants completed the National Comprehensive Cancer Network Distress Thermometer and Problem List and had a follow-up screening discussion with a health professional...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28033439/a-standard-set-of-value-based-patient-centered-outcomes-for-breast-cancer-the-international-consortium-for-health-outcomes-measurement-ichom-initiative
#12
Wee Loon Ong, Maartje G Schouwenburg, Annelotte C M van Bommel, Caleb Stowell, Kim H Allison, Karen E Benn, John P Browne, Rodney D Cooter, Geoff P Delaney, Francois P Duhoux, Patricia A Ganz, Patricia Hancock, Reshma Jagsi, Felicia M Knaul, Anne M Knip, Linetta B Koppert, Henry M Kuerer, Sarah McLaughin, Marc A M Mureau, Ann H Partridge, Dereesa Purtell Reid, Lisa Sheeran, Thomas J Smith, Mark J Stoutjesdijk, Marie Jeanne T F D Vrancken Peeters, Yvonne Wengström, Cheng-Har Yip, Christobel Saunders
A major challenge in value-based health care is the lack of standardized health outcomes measurements, hindering optimal monitoring and comparison of the quality of health care across different settings globally. The International Consortium for Health Outcomes Measurement (ICHOM) assembled a multidisciplinary international working group, comprised of 26 health care providers and patient advocates, to develop a standard set of value-based patient-centered outcomes for breast cancer (BC). The working group convened via 8 teleconferences and completed a follow-up survey after each meeting...
May 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/27991859/breath-mass-ion-biomarkers-of-breast-cancer
#13
Michael Phillips, Renee Cataneo, Cassie Lebauer, Mayur Mundada, Christobel Saunders
BACKGROUND: Breath volatile organic compounds (VOCs) contain biomarkers of breast cancer that are detectable with gas chromatography mass spectrometry (GC MS). However, chemical identification of breath VOC biomarkers may be erroneous because spectral matching can misidentify their structure. Breath mass ions detected with GC MS have been proposed as intrinsically robust biomarkers because they can be identified without spectral matching. We investigated whether breath mass ion biomarkers could identify breast cancer...
December 19, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27987454/patient-reported-outcomes-in-ductal-carcinoma-in-situ-a-systematic-review
#14
REVIEW
Madeleine T King, Zoë E Winters, Ivo A Olivotto, Andrew J Spillane, Boon H Chua, Christobel Saunders, A Helen Westenberg, G Bruce Mann, Petrina Burnett, Phyllis Butow, Claudia Rutherford
Ductal carcinoma in situ (DCIS) is a pre-invasive breast cancer with excellent prognosis but with potential adverse impacts of diagnosis and treatment on quality of life and other patient-reported outcomes (PROs). We undertook a systematic review to synthesise current evidence about PROs following diagnosis and treatment for DCIS. We searched five electronic databases (from database inception to November 2015), cross-referenced and contacted experts to identify studies that reported PROs after DCIS treatment...
January 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/27867721/wide-field-optical-coherence-micro-elastography-for-intraoperative-assessment-of-human-breast-cancer-margins
#15
Wes M Allen, Lixin Chin, Philip Wijesinghe, Rodney W Kirk, Bruce Latham, David D Sampson, Christobel M Saunders, Brendan F Kennedy
Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27829404/investigation-of-optical-coherence-micro-elastography-as-a-method-to-visualize-micro-architecture-in-human-axillary-lymph-nodes
#16
Kelsey M Kennedy, Lixin Chin, Philip Wijesinghe, Robert A McLaughlin, Bruce Latham, David D Sampson, Christobel M Saunders, Brendan F Kennedy
BACKGROUND: Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale mechanical properties of lymph nodes could, thus, provide diagnostic information to aid in the assessment of lymph node involvement in metastatic cancer...
November 9, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27810485/breast-cancer-risk-and-the-interaction-between-adolescent-body-size-and-weight-gain-in-later-life-a-case-control-study
#17
Ines Florath, Danja Sarink, Christobel Saunders, Jane Heyworth, Lin Fritschi
BACKGROUND: While the breast cancer risk associated with increasing adult BMI in postmenopausal women can be explained by increases in concentrations of endogenous estrogens the biologic mechanisms behind the inverse association between adolescent BMI and breast cancer risk are still a subject of controversial debate. METHODS: We investigated the association of breast cancer with body size and changes in body size across life time estimated by age-specific BMI Z scores and changes in BMI Z scores from teenage years to middle age in an age-matched population-based case-control study of 2994 Australian women...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27784140/not-all-ductal-carcinoma-in-situ-is-created-equal-can-we-avoid-surgery-for-low-risk-ductal-carcinoma-in-situ
#18
REVIEW
Jocelyn Lippey, Andrew Spillane, Christobel Saunders
No abstract text is available yet for this article.
November 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27739214/switching-between-endocrine-therapies-for-primary-breast-cancer-frequency-and-timing-in-australian-clinical-practice
#19
Anna Kemp-Casey, Elizabeth E Roughead, Christobel Saunders, Frances Boyle, Max Bulsara, David B Preen
AIMS: To determine the frequency, timing and patterns of endocrine therapy switching in Australian practice for postmenopausal women with primary breast cancer. METHODS: We identified postmenopausal women in a population-based cohort commencing endocrine therapy for invasive primary breast cancer between December 2005 and December 2008 (n = 645). Individual-level administrative health records and self-report data were used to determine women's demographic and clinical characteristics, including preexisting and newly-treated comorbidities, and switches in endocrine therapy...
April 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27701839/breast-localization-techniques-and-margin-definitions-used-by-australian-and-new-zealand-surgeons
#20
Donna B Taylor, Anita G Bourke, Max M Hobbs, Glenys Dixon, Michael Phillips, Christobel M Saunders
No abstract text is available yet for this article.
October 2016: ANZ Journal of Surgery
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