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christobel saunders

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https://www.readbyqxmd.com/read/27867721/wide-field-optical-coherence-micro-elastography-for-intraoperative-assessment-of-human-breast-cancer-margins
#1
Wes M Allen, Lixin Chin, Philip Wijesinghe, Rodney W Kirk, Bruce Latham, David D Sampson, Christobel M Saunders, Brendan F Kennedy
Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27829404/investigation-of-optical-coherence-micro-elastography-as-a-method-to-visualize-micro-architecture-in-human-axillary-lymph-nodes
#2
Kelsey M Kennedy, Lixin Chin, Philip Wijesinghe, Robert A McLaughlin, Bruce Latham, David D Sampson, Christobel M Saunders, Brendan F Kennedy
BACKGROUND: Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale mechanical properties of lymph nodes could, thus, provide diagnostic information to aid in the assessment of lymph node involvement in metastatic cancer...
November 9, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27810485/breast-cancer-risk-and-the-interaction-between-adolescent-body-size-and-weight-gain-in-later-life-a-case-control-study
#3
Ines Florath, Danja Sarink, Christobel Saunders, Jane Heyworth, Lin Fritschi
BACKGROUND: While the breast cancer risk associated with increasing adult BMI in postmenopausal women can be explained by increases in concentrations of endogenous estrogens the biologic mechanisms behind the inverse association between adolescent BMI and breast cancer risk are still a subject of controversial debate. METHODS: We investigated the association of breast cancer with body size and changes in body size across life time estimated by age-specific BMI Z scores and changes in BMI Z scores from teenage years to middle age in an age-matched population-based case-control study of 2994 Australian women...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27784140/not-all-ductal-carcinoma-in-situ-is-created-equal-can-we-avoid-surgery-for-low-risk-ductal-carcinoma-in-situ
#4
Jocelyn Lippey, Andrew Spillane, Christobel Saunders
No abstract text is available yet for this article.
November 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27739214/switching-between-endocrine-therapies-for-primary-breast-cancer-frequency-and-timing-in-australian-clinical-practice
#5
Anna Kemp-Casey, Elizabeth E Roughead, Christobel Saunders, Frances Boyle, Max Bulsara, David B Preen
AIMS: To determine the frequency, timing and patterns of endocrine therapy switching in Australian practice for postmenopausal women with primary breast cancer. METHODS: We identified postmenopausal women in a population-based cohort commencing endocrine therapy for invasive primary breast cancer between December 2005 and December 2008 (n = 645). Individual-level administrative health records and self-report data were used to determine women's demographic and clinical characteristics, including preexisting and newly-treated comorbidities, and switches in endocrine therapy...
October 14, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27701839/breast-localization-techniques-and-margin-definitions-used-by-australian-and-new-zealand-surgeons
#6
Donna B Taylor, Anita G Bourke, Max M Hobbs, Glenys Dixon, Michael Phillips, Christobel M Saunders
No abstract text is available yet for this article.
October 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27689969/an-international-randomised-controlled-trial-to-compare-targeted-intraoperative-radiotherapy-targit-with-conventional-postoperative-radiotherapy-after-breast-conserving-surgery-for-women-with-early-stage-breast-cancer-the-targit-a-trial
#7
Jayant S Vaidya, Frederik Wenz, Max Bulsara, Jeffrey S Tobias, David J Joseph, Christobel Saunders, Chris Brew-Graves, Ingrid Potyka, Stephen Morris, Hrisheekesh J Vaidya, Norman R Williams, Michael Baum
BACKGROUND: Based on our laboratory work and clinical trials we hypothesised that radiotherapy after lumpectomy for breast cancer could be restricted to the tumour bed. In collaboration with the industry we developed a new radiotherapy device and a new surgical operation for delivering single-dose radiation to the tumour bed - the tissues at highest risk of local recurrence. We named it TARGeted Intraoperative radioTherapy (TARGIT). From 1998 we confirmed its feasibility and safety in pilot studies...
September 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27684037/streamlined-genetic-education-is-effective-in-preparing-women-newly-diagnosed-with-breast-cancer-for-decision-making-about-treatment-focused-genetic-testing-a-randomized-controlled-noninferiority-trial
#8
Veronica F Quinn, Bettina Meiser, Judy Kirk, Kathy M Tucker, Kaaren J Watts, Belinda Rahman, Michelle Peate, Christobel Saunders, Elizabeth Geelhoed, Margaret Gleeson, Kristine Barlow-Stewart, Michael Field, Marion Harris, Yoland C Antill, Linda Cicciarelli, Karen Crowe, Michael T Bowen, Gillian Mitchell
PURPOSE: Increasingly, women newly diagnosed with breast cancer are being offered treatment-focused genetic testing (TFGT). As the demand for TFGT increases, streamlined methods of genetic education are needed. METHODS: In this noninferiority trial, women aged <50 years with either a strong family history (FH+) or other features suggestive of a germ-line mutation (FH-) were randomized before definitive breast cancer surgery to receive TFGT education either as brief written materials (intervention group (IG)) or during a genetic counseling session at a familial cancer clinic (usual-care group (UCG))...
September 29, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27682335/exploring-breast-health-practices-of-post-menopausal-women-implications-to-informed-consent
#9
Kristen Seaman, Peta Dzidic, Lauren Breen, Christobel Saunders
In light of the contention surrounding breast health practices, the research aimed to explore post-menopausal women's experiences of such practices. Semi-structured interviews were conducted in July and August 2015 with 13 Australian women aged 54-74 years. Data were analysed thematically. Participants deemed their engagement with breast health practices as the 'right' thing. However, engaging in these 'right' practices appeared to be fostered by misconceptions. The findings suggest that women may not be making evidence-informed decisions to engage in breast screening; identify contemporary barriers to promoting informed decisions; and may inform information pertinent to breast screening policy, campaigns and decision aid designs...
September 28, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27618159/simplifying-the-assessment-of-human-breast-cancer-by-mapping-a-micro-scale-heterogeneity-index-in-optical-coherence-elastography
#10
Lixin Chin, Bruce Latham, Christobel M Saunders, David D Sampson, Brendan F Kennedy
Surgical treatment of breast cancer aims to identify and remove all malignant tissue. Intraoperative assessment of tumor margins is, however, not exact; thus, re-excision is frequently needed, or excess normal tissue is removed. Imaging methods applicable intraoperatively could help to reduce re-excision rates whilst minimizing removal of excess healthy tissue. Optical coherence elastography (OCE) has been proposed for use in breast-conserving surgery; however, intraoperative interpretation of complex OCE images may prove challenging...
September 12, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27592287/sexuality-and-quality-of-life-in-women-with-a-prior-diagnosis-of-breast-cancer-after-risk-reducing-salpingo-oophorectomy
#11
Paige E Tucker, Christobel Saunders, Max K Bulsara, Jason Jit-Sun Tan, Stuart G Salfinger, Helena Green, Paul A Cohen
OBJECTIVES: To investigate the prevalence of sexual dysfunction in women with a history of breast cancer following risk-reducing salpingo-oophorectomy (RRSO). A secondary objective was to examine the effect of a prior diagnosis of breast cancer, and other factors, on sexuality and quality of life (QoL) outcomes. STUDY DESIGN: Cross-sectional study of 119 women who underwent RRSO between 2009 and 2014. MAIN OUTCOME MEASURES: Data were collected via a questionnaire comprising demographic information and validated measures of sexual function, sexual distress, relationship satisfaction, body image, psychological stress, menopause symptoms and general quality of life...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27511847/cosmesis-and-breast-related-quality-of-life-outcomes-after-intraoperative-radiation-therapy-for-early-breast-cancer-a-substudy-of-the-targit-a-trial
#12
Tammy Corica, Anna K Nowak, Christobel M Saunders, Max Bulsara, Mandy Taylor, Jayant S Vaidya, Michael Baum, David J Joseph
PURPOSE: To report the first comprehensive investigation of patient-reported cosmesis and breast-related quality of life (QOL) outcomes comparing patients randomized to risk-adapted single-dose intraoperative radiation therapy (TARGIT-IORT) versus external beam radiation therapy (EBRT) on the TARGIT-A trial. METHODS AND MATERIALS: Longitudinal cosmesis and QOL data were collected from a subset of TARGIT-A participants who received TARGIT-IORT as a separate procedure (postpathology)...
September 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27478165/reduced-mortality-with-partial-breast-irradiation-for-early-breast-cancer-a%C3%A2-meta-analysis-of-randomized-trials
#13
Jayant S Vaidya, Max Bulsara, Frederik Wenz, Nathan Coombs, Julian Singer, Stephen Ebbs, Samuele Massarut, Christobel Saunders, Michael Douek, Norman R Williams, David Joseph, Jeffrey S Tobias, Michael Baum
PURPOSE: With earlier detection and more effective treatment, mortality from breast cancer continues to fall and it has become increasingly important to reduce the toxicity of treatments. Partial-breast radiation therapy, which focuses radiation to the tumor bed, may achieve this aim. We analyzed mortality differences in randomized trials of partial-breast irradiation (PBI). METHODS AND MATERIALS: We included data from published randomized trials of PBI (alone or as part of a risk-adapted approach) versus whole-breast irradiation (WBI) for invasive breast cancer suitable for breast-conserving therapy...
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27318167/decision-making-psychological-wellbeing-and-psychosocial-outcomes-for-high-risk-women-who-choose-to-undergo-bilateral-prophylactic-mastectomy-a-review-of-the-literature
#14
REVIEW
Rachael Glassey, Angela Ives, Christobel Saunders, Toni Musiello
A bilateral prophylactic, or preventative, mastectomy (BPM) for women at high risk of developing breast cancer (BC) can reduce their risk of developing the disease by up to 90% (relative risk reduction). An increasing number of women, including young women, are taking up this option. However, there is a dearth of information for younger women (under 40 years) choosing preventative mastectomy. In fact, no studies to date have specifically focused on younger women's experiences of a BPM and investigated their informational needs...
August 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27272225/how-does-adjuvant-chemotherapy-affect-menopausal-symptoms-sexual-function-and-quality-of-life-after-breast-cancer
#15
Jennifer L Marino, Christobel M Saunders, Laura I Emery, Helena Green, Dorota A Doherty, Martha Hickey
OBJECTIVE: The aim of the study was to determine the association between adjuvant chemotherapy for breast cancer and menopausal symptoms, sexual function, and quality of life. METHODS: Participants attended a menopause clinic with a dedicated service for cancer survivors at a large tertiary women's hospital. Information about breast cancer treatments including adjuvant chemotherapy was collected from medical records. Menopausal symptoms were recorded with the Greene Climacteric Scale and Functional Assessment of Cancer Therapy, Breast Cancer, and Endocrine Symptom Subscales...
September 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27094805/occupational-exposures-to-engine-exhausts-and-other-pahs-and-breast-cancer-risk-a-population-based-case-control-study
#16
Rajni Rai, Deborah C Glass, Jane S Heyworth, Christobel Saunders, Lin Fritschi
BACKGROUND: Some previous studies have suggested that exposure to engine exhausts may increase risk of breast cancer. METHODS: In a population-based case-control study of breast cancer in Western Australia we assessed occupational exposure to engine exhausts using questionnaires and telephone interviews. Odds Ratios (OR) and 95% Confidence Intervals (CI) were calculated using logistic regression. RESULTS: We found no association between risk of breast cancer and occupational exposure to diesel exhaust (OR 1...
June 2016: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/27058152/florid-pustular-dermatitis-of-breast-a-case-report-on-a-unusual-complication-from-acellular-dermal-matrix-use
#17
Justin James, Lee Jackson, Christobel Saunders
INTRODUCTION: Idiopathic erythematous reaction of the breast (Red breast syndrome) is a known complication following breast reconstruction with acellular dermal matrix. However pustular dermatitis like presentation is not previously known. PRESENTATION OF CASE: We present a 42-year-old lady who developed bilateral pustular dermatitis like appearance following breast reconstruction with acellular dermal matrix slings. Though surgical washout was done, both expanders and flex HD could be preserved...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27023258/theoretical-versus-ex-vivo-assessment-of-radiation-damage-repair-an-investigation-in-normal-breast-tissue
#18
Martin A Ebert, Bipina Dhal, Janelle Prunster, Sally McLaren, Nikolajs Zeps, Michael House, Brigitte Reniers, Frank Verhaegen, Tammy Corica, Christobel Saunders, David J Joseph
In vivo validation of models of DNA damage repair will enable their use for optimizing clinical radiotherapy. In this study, a theoretical assessment was made of DNA double-strand break (DSB) induction in normal breast tissue after intraoperative radiation therapy (IORT), which is now an accepted form of adjuvant radiotherapy for selected patients with early breast cancer. DSB rates and relative biological effectiveness (RBE) were calculated as a function of dose, radiation quality and dose rate, each varying based on the applicator size used during IORT...
April 2016: Radiation Research
https://www.readbyqxmd.com/read/26990046/iodine-125-seeds-to-guide-removal-of-impalpable-breast-lesions-radio-guided-occult-lesion-localization-a-pilot-study
#19
Anita G Bourke, Donna B Taylor, Eliza Westcott, Max Hobbs, Christobel Saunders
BACKGROUND: The aim of this study was to confirm that radio-guided occult lesion localization using low activity iodine 125 (I-125) seeds (ROLLIS) could be safely and accurately used for localization and guided excision of impalpable breast lesions in different multidisciplinary settings and to prepare staff for a randomized controlled trial. METHOD: Preoperative image-guided localization of 102 lesions using one or two I-125 seeds with hook-wire back-up was performed in 99 participants at two tertiary hospitals...
March 16, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/26899402/inflammatory-breast-cancer-a-decade-of-experience
#20
Vinicius C Do Nascimento, Ruben Rajan, Andrew Redfern, Christobel Saunders
Inflammatory breast cancer (IBC) is an aggressive and rare form of breast cancer. At present, there are no established diagnostic, radiological, pathological or molecular diagnostic criteria for this entity. The aim of this study was to examine the patterns of presentation, treatment and outcomes of IBC in this institution over the course of a decade. This is a retrospective observational study using data from the Royal Perth Hospital from January 2001 to December 2010. Our results identified 57 women with IBC, representing 1...
September 2016: Asia-Pacific Journal of Clinical Oncology
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