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https://www.readbyqxmd.com/read/28340622/anti-plasmodial-activity-of-norcaesalpin-d-and-extracts-of-four-medicinal-plants-used-traditionally-for-treatment-of-malaria
#1
Ramadhani Selemani Omari Nondo, Mainen Julius Moshi, Paul Erasto, Pax Jessey Masimba, Francis Machumi, Abdul Waziri Kidukuli, Matthias Heydenreich, Denis Zofou
BACKGROUND: Malaria is an old life-threatening parasitic disease that is still affecting many people, mainly children living in sub-Saharan Africa. Availability of effective antimalarial drugs played a significant role in the treatment and control of malaria. However, recent information on the emergence of P. falciparum parasites resistant to one of the artemisinin-based combination therapies suggests the need for discovery of new drug molecules. Therefore, this study aimed to evaluate the antiplasmodial activity of extracts, fractions and isolated compound from medicinal plants traditionally used in the treatment of malaria in Tanzania...
March 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28325485/the-effects-of-interprofessional-education-self-reported-professional-competence-among-prehospital-emergency-care-nursing-students-on-the-point-of-graduation-a-cross-sectional-study
#2
M Castrèn, M Mäkinen, J Nilsson, V Lindström
The aim of the study was to investigate whether interprofessional education (IPE) and interprofessional collaboration (IPC) during the educational program had an impact on prehospital emergency care nurses' (PECN) self-reported competence towards the end of the study program. A cross-sectional study using the Nurse Professional Competence (NPC) Scale was conducted. A comparison was made between PECN students from Finland who experienced IPE and IPC in the clinical setting, and PECN students from Sweden with no IPE and a low level of IPC...
March 16, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28323573/real-time-direct-evidence-of-the-superficial-lymphatic-drainage-effect-of-intermittent-pneumatic-compression-treatment-for-lower-limb-lymphedema
#3
Shinya Kitayama, Jiro Maegawa, Shinobu Matsubara, Shinji Kobayashi, Taro Mikami, Koichi Hirotomi, Shintaro Kagimoto
BACKGROUND: Intermittent pneumatic compression (IPC) is a widely used lymph drainage therapy that can be performed at home. However, the effectiveness of IPC for lymph drainage remains unclear. The aim of this study is to investigate the real-time change in the lymph flow velocity during IPC and consider which mode and pressure are best for treating lower limb lymphedema. METHODS AND RESULTS: Eight lower left limbs of 8 healthy volunteers and 17 lower limbs of 15 secondary lymphedema patients were investigated...
March 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28318143/designing-squaraines-to-control-charge-injection-and-recombination-processes-in-nio-based-dye-sensitized-solar-cells
#4
Oliver Langmar, Davide Saccone, Anna Amat, Simona Fantacci, Guido Viscardi, Claudia Barolo, Ruben Costa, Dirk Michael Guldi
Herein, the synthesis of a novel family of squaraines (SQ) and their application in p-type dye-sensitized solar cells (DSSC) is presented. In particular, two sets of SQs were designed. The SQs have been characterized by using a joint theoretical, photophysical and electrochemical approach. Importantly, the presence of different central groups forces them into a frozen cis (dicyanovinyl group) or a trans (oxygen group) conformation. Based on the latter, the current work enables the direct comparison between cis and trans isomers, as well as the impact of a different number of anchors...
March 20, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28300495/hospital-acquired-infections-in-paediatric-medical-wards-at-a-tertiary-hospital-in-kwazulu-natal-south-africa
#5
Kevin B Spicer, Jennifer Green, Barnesh Dhada
BACKGROUND: Hospital-acquired infections (HAIs) impact care and costs in hospitals across the globe. There are minimal data on HAIs in sub-Saharan Africa and data specific to paediatrics are especially limited. OBJECTIVE: To describe the incidence of HAIs in the paediatric medical units at Grey's Hospital, a tertiary government hospital in KwaZulu-Natal, South Africa. METHODS: The Infection Prevention and Control (IPC) team collects data on all laboratory-confirmed infections, including from paediatric patients in two medical units (52 beds), the paediatric intensive/high-care unit (PICU, 8 beds) and the neonatal intensive care unit (NICU, 23 beds)...
March 16, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28298332/impact-of-lifelong-exercise-training-on-endothelial-ischemia-reperfusion-and-ischemic-preconditioning-in-humans
#6
Martijn F H Maessen, Anke Ccm van Mil, Yaïra Straathof, Niels P Riksen, Gerard A P J M Rongen, Maria T E Hopman, Thijs M H Eijsvogels, Dick H J Thijssen
Reperfusion is essential for ischemic tissue survival, but causes additional damage to the endothelium (i.e. ischemia-reperfusion [IR] injury). Ischemic preconditioning (IPC) refers to short repetitive episodes of ischemia that can protect against IR. However, IPC efficacy attenuates with older age. Whether physical inactivity contributes to the attenuated efficacy of IPC to protect against IR injury in older humans is unclear. We tested the hypotheses that lifelong exercise training relates to 1) attenuated endothelial IR and 2) maintained IPC efficacy that protects veteran athletes against endothelial IR...
March 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28295998/expansion-of-the-ador-strategy-for-the-synthesis-of-zeolites-the-synthesis-of-ipc-12-from-zeolite-uov
#7
Valeryia Kasneryk, Mariya Shamzhy, Maksym Opanasenko, Paul S Wheatley, Samuel A Morris, Samantha E Russell, Alvaro Mayoral, Michal Trachta, Jiří Čejka, Russell E Morris
The assembly-disassembly-organization-reassembly (ADOR) process has been used to disassemble a parent zeolite with the UOV structure type and then reassemble the resulting layers into a novel structure, IPC-12. The structure of the material has previously been predicted computationally and confirmed in our experiments using X-ray diffraction and atomic resolution STEM-HAADF electron microscopy. This is the first successful application of the ADOR process to a material with porous layers.
March 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28294175/the-age-associated-loss-of-ischemic-preconditioning-in-the-kidney-is-accompanied-by-mitochondrial-dysfunction-increased-protein-acetylation-and-decreased-autophagy
#8
Stanislovas S Jankauskas, Irina B Pevzner, Nadezda V Andrianova, Ljubava D Zorova, Vasily A Popkov, Denis N Silachev, Nataliya G Kolosova, Egor Y Plotnikov, Dmitry B Zorov
In young rats, ischemic preconditioning (IPC), which consists of 4 cycles of ischemia and reperfusion alleviated kidney injury caused by 40-min ischemia. However,old rats lost their ability to protect the ischemic kidney by IPC. A similar aged phenotype was demonstrated in 6-month-old OXYS rats having signs of premature aging. In the kidney of old and OXYS rats, the levels of acetylated nuclear proteins were higher than in young rats, however, unlike in young rats, acetylation levels in old and OXYS rats were further increased after IPC...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28294149/oral-health-in-relation-to-all-cause-mortality-the-ipc-cohort-study
#9
Margaux Adolph, Christelle Darnaud, Frédérique Thomas, Bruno Pannier, Nicolas Danchin, G David Batty, Philippe Bouchard
We evaluated the association between oral health and mortality. The study population comprised 76,188 subjects aged 16-89 years at recruitment. The mean follow-up time was 3.4 ± 2.4 years. Subjects with a personal medical history of cancer or cardiovascular disease and death by casualty were excluded from the analysis. A full-mouth clinical examination was performed in order to assess dental plaque, dental calculus and gingival inflammation. The number of teeth and functional masticatory units <5 were recorded...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293875/angiotensin-1-7-facilitates-cardioprotection-of-ischemic-preconditioning-on-ischemia-reperfusion-challenged-rat-heart
#10
Pradeepkant Pachauri, Debapriya Garabadu, Ahsas Goyal, Prabhat Kumar Upadhyay
Ischemic preconditioning (IPC) is one of the most promising strategies used to protect the myocardium from ischemia-reperfusion injury. Ang (1-7) exhibits cardioprotective activity; however, its therapeutic potential on IPC-induced cardioprotection has not been reported in ischemia-reperfusion injury till date. Therefore, the first set of experiment was designed to evaluate the direct effect of Ang (1-7), in perfusion medium, on cardioprotective activity of IPC in rat heart challenged to ischemia-reperfusion injury...
March 14, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28291543/cell-membrane-integrity-and-revascularization-the-possible-functional-mechanism-of-ischemic-preconditioning-for-skeletal-muscle-protection-against-ischemic-reperfusion-injury
#11
Yang Hong, Bin Zhang, Ling Yu, Shan-Shan Duan
BACKGROUND: The purpose of this paper was to evaluate whether ischemic preconditioning (IPC) could make protective effects against skeletal muscle injuries induced by ischemic-reperfusion (I/R). METHODS: Eighteen rats were randomly divided into three groups of 6 subjects each: control group, I/R group, and IPC group. Thigh root ischemia of rats in the I/R group was induced by 3h ischemia and 24h reperfusion. IPC was applied by 3 periods of 15min ischemia/15min reperfusion prior to ischemia...
March 10, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28288872/local-renin-angiotensin-system-regulates-the-differentiation-of-mesenchymal-stem-cells-into-insulin-producing-cells-through-angiotensin-type-2-receptor
#12
Nermin Abdel-Hamid Sadik, Nadia Said Metwally, Olfat Gamil Shaker, Mahmoud Sanad Soliman, Ahmed Abdelaziz Mohamed, Mai Mohamed Abdelmoaty
Differentiation of stem cells into insulin-producing cells (IPCs) suitable for therapeutic transplantation offers a desperately needed approach for the diabetic patients. Elucidation of the molecular mechanisms during the differentiation of MSCs into IPCs assists the successful production of IPCs and provides an important insight into the improvement of the role of MSCs as a therapeutic tool for diabetes mellitus. The present study aimed to investigate the role of local renin-angiotensin system (RAS) on MSCs differentiation into IPCs by measuring the expression of local RAS in MSCs during the differentiation into IPCs and assessing the effect of angiotensin type 1 receptor (AT1R) blocker and angiotensin type 2 receptor (AT2R) blocker on the differentiation process...
March 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28279194/crispr-targeted-genome-editing-of-mesenchymal-stem-cell-derived-therapies-for-type-1-diabetes-a-path-to-clinical-success
#13
REVIEW
Dario Gerace, Rosetta Martiniello-Wilks, Najah Therese Nassif, Sara Lal, Raymond Steptoe, Ann Margaret Simpson
Due to their ease of isolation, differentiation capabilities, and immunomodulatory properties, the therapeutic potential of mesenchymal stem cells (MSCs) has been assessed in numerous pre-clinical and clinical settings. Currently, whole pancreas or islet transplantation is the only cure for people with type 1 diabetes (T1D) and, due to the autoimmune nature of the disease, MSCs have been utilised either natively or transdifferentiated into insulin-producing cells (IPCs) as an alternative treatment. However, the initial success in pre-clinical animal models has not translated into successful clinical outcomes...
March 9, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28269997/pgc-1%C3%AE-downregulation-in-the-steatotic-liver-enhances-ischemia-reperfusion-injury-and-impairs-ischemic-preconditioning
#14
Cristina Sánchez Ramos, Ignacio Prieto, Alberto Tierrez, Javier Laso, M Pilar Valdecantos, Ramón Bartrons, Joan Rosello-Catafau, Maria Monsalve
AIMS: Liver steatosis is associated with mitochondrial dysfunction and elevated reactive oxygen species (ROS) levels together with enhanced sensitivity to ischemia-reperfusion (IR) injury and limited response to preconditioning protocols. Here, we sought to determine whether the downregulation in the steatotic liver of peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α), a master regulator of mitochondrial metabolism and ROS that is known to play a role in liver metabolic control, could be responsible for the sensitivity of steatotic liver to ischemic damage...
March 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28261425/intermittent-pneumatic-compression-for-the-prevention-of-venous-thromboembolism-after-total-hip-arthroplasty
#15
Hong Suk Kwak, Jai Ho Cho, Jung Taek Kim, Jeong Joon Yoo, Hee Joong Kim
BACKGROUND: Venous thromboembolism (VTE) is a relatively common and potentially life threatening complication after major hip surgery. There are two main types of prophylaxis: chemical and mechanical. Chemical prophylaxis is very effective but causes bleeding complications in surgical wounds and remote organs. On the other hand, mechanical methods are free of hemorrhagic complications but are less effective. We hypothesized that mechanical prophylaxis is effective enough for Asians in whom VTE occurs less frequently...
March 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28261301/cardiomyocyte-mitochondria-as-targets-of-humoral-factors-released-by-remote-ischemic-preconditioning
#16
Nilguen Gedik, Leonardo Maciel, Christiane Schulte, Andreas Skyschally, Gerd Heusch, Petra Kleinbongard
INTRODUCTION: Remote ischemic preconditioning (RIPC) reduces myocardial infarct size, and protection can be transferred with plasma to other individuals, even across species. Mitochondria are the end-effectors of cardioprotection by local ischemic conditioning maneuvers. We have now analyzed mitochondrial function in response to RIPC. MATERIAL AND METHODS: Plasma from pigs undergoing placebo or RIPC (infarct size reduction by 67% in RIPC pigs compared to placebo) was transferred to isolated perfused rat hearts subjected to 30 min global ischemia followed by 120 min reperfusion for infarct size measurement...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28260408/dynamic-workplace-interactions-for-improving-patient-safety-climate
#17
Susan Brandis, John Rice, Stephanie Schleimer
Purpose Employee engagement (EE), supervisor support (SS) and interprofessional collaboration (IPC) are important contributors to patient safety climate (PSC). The purpose of this paper is to propose and empirically test a model that suggests the presence of a three-way interaction effect between EE, IPC and SS in creating a stronger PSC. Design/methodology/approach Using validated tools to measure EE, SS, IPC and PSC data were collected from a questionnaire of 250 clinical and support staff in an Australian health service...
March 20, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28257116/valorization-of-lipids-from-gracilaria-sp-through-lipidomics-and-decoding-of-antiproliferative-and-anti-inflammatory-activity
#18
Elisabete da Costa, Tânia Melo, Ana S P Moreira, Carina Bernardo, Luisa Helguero, Isabel Ferreira, Maria Teresa Cruz, Andreia M Rego, Pedro Domingues, Ricardo Calado, Maria H Abreu, Maria Rosário Domingues
The lipidome of the red seaweed Gracilaria sp., cultivated on land-based integrated multitrophic aquaculture (IMTA) system, was assessed for the first time using hydrophilic interaction liquid chromatography-mass spectrometry and tandem mass spectrometry (HILIC-MS and MS/MS). One hundred and forty-seven molecular species were identified in the lipidome of the Gracilaria genus and distributed between the glycolipids classes monogalactosyl diacylglyceride (MGDG), digalactosyl diacylglyceride (DGDG), sulfoquinovosyl monoacylglyceride (SQMG), sulfoquinovosyl diacylglyceride (SQDG), the phospholipids phosphatidylcholine (PC), lyso-PC, phosphatidylglycerol (PG), lyso-PG, phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatic acid (PA), inositolphosphoceramide (IPC), and betaine lipids monoacylglyceryl- and diacylglyceryl-N,N,N-trimethyl homoserine (MGTS and DGTS)...
March 2, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28252337/accelerated-wound-healing-with-combined-npwt-and-ipc-a-case-series
#19
Kristian Arvesen, Camilla Bak Nielsen, Karsten Fogh
Negative pressure wound therapy (NPWT) and intermittent pneumatic compression (IPC) have traditionally been used in patients with chronic complicated non-healing wounds. The aim of this study (retrospective case series) was to describe the use of NPWT in combination with IPC in patients with a relatively short history (2-6 months) of ulcers. All wounds showed improved healing during the treatment period with marked or moderate reduction in ulcer size, and granulation tissue formation was markedly stimulated...
March 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28249104/dual-functional-surfactant-templated-strategy-for-synthesis-of-an-in-situ-n2-intercalated-mesoporous-wo3-photoanode-for-efficient-visible-light-driven-water-oxidation
#20
Dong Li, Debraj Chandra, Ryouchi Takeuchi, Takanari Togashi, Masato Kurihara, Kenji Saito, Tatsuto Yui, Masayuki Yagi
N2-intercalated crystalline mesoporous tungsten trioxide (WO3) was synthesized by a thermal decomposition technique using dodecylamine (DDA) as a surfactant template with a dual functional role of an N atom source for N2 intercalation, alongside its conventional structure directing role (by micelle formation) to induce a mesoporous structure. N2 physisorption analysis showed that the specific surface area (57.3 m2 g-1) of WO3 (WO3-DDA) templated with DDA is 2.3 times higher than that (24.5 m2 g-1) of WO3 (WO3-bulk) prepared without DDA due to the mesoporous structure of WO3-DDA...
March 1, 2017: Chemistry: a European Journal
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