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https://www.readbyqxmd.com/read/28091727/intrinsic-cardiac-ganglia-and-acetylcholine-are-important-in-the-mechanism-of-ischaemic-preconditioning
#1
J M J Pickard, N Burke, S M Davidson, D M Yellon
This study aimed to investigate the role of the intrinsic cardiac nervous system in the mechanism of classical myocardial ischaemic preconditioning (IPC). Isolated perfused rat hearts were subjected to 35-min regional ischaemia and 60-min reperfusion. IPC was induced as three cycles of 5-min global ischaemia-reperfusion, and provided significant reduction in infarct size (IS/AAR = 14 ± 2% vs control IS/AAR = 48 ± 3%, p < 0.05). Treatment with the ganglionic antagonist, hexamethonium (50 μM), blocked IPC protection (IS/AAR = 37 ± 7%, p < 0...
March 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28090703/differentiation-of-islet-progenitors-regulated-by-nicotinamide-into-transcriptome-verified-%C3%AE-cells-that-ameliorate-diabetes
#2
Fang-Xu Jiang, Kevin Li, Michael Archer, Munish Mehta, Emma Jamieson, Adrian Charles, Jan E Dickinson, Masahito Matsumoto, Grant Morahan
Developmental stage-specific differentiation of stem or progenitor cells into safe and functional cells is of fundamental importance in regenerative medicine, including β-cell replacement. However, the differentiation of islet progenitor cells (IPCs) into insulin-secreting β cells remains elusive. Here, we report that the multi-functional molecule nicotinamide (NIC) is a specific differentiation regulator of mouse IPCs. The differentiated cells regulated by NIC exhibited many characteristics of adult β cells, including ameliorating preclinical diabetes and a highly comparable transcriptome profile...
January 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28088690/electrochemical-studies-of-dna-interaction-and-antimicrobial-activities-of-mn-ii-fe-iii-co-ii-and-ni-ii-schiff-base-tetraazamacrocyclic-complexes
#3
Anuj Kumar, Vinod Kumar Vashistha, Prashant Tevatia, Randhir Singh
Tetraazamacrocyclic complexes of Mn(II), Fe(III), Co(II) and Ni(II) have been synthesized by template method. These tetraazamacrocycles have been analyzed with various techniques like molar conductance, IR, UV-vis, mass spectral and cyclic voltammetric studies. On the basis of all these studies, octahedral geometry has been assigned to these tetraazamacrocyclic complexes. The DNA binding properties of these macrocyclic complexes have been investigated by electronic absorption spectra, fluorescence spectra, cyclic voltammetric and differential pulse voltammetric studies...
January 6, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28078082/core-components-for-effective-infection-prevention-and-control-programmes-new-who-evidence-based-recommendations
#4
Julie Storr, Anthony Twyman, Walter Zingg, Nizam Damani, Claire Kilpatrick, Jacqui Reilly, Lesley Price, Matthias Egger, M Lindsay Grayson, Edward Kelley, Benedetta Allegranzi
Health care-associated infections (HAI) are a major public health problem with a significant impact on morbidity, mortality and quality of life. They represent also an important economic burden to health systems worldwide. However, a large proportion of HAI are preventable through effective infection prevention and control (IPC) measures. Improvements in IPC at the national and facility level are critical for the successful containment of antimicrobial resistance and the prevention of HAI, including outbreaks of highly transmissible diseases through high quality care within the context of universal health coverage...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28077312/the-effect-of-calf-neuromuscular-electrical-stimulation-and-intermittent-pneumatic-compression-on-thigh-microcirculation
#5
Shayan Bahadori, Tikki Immins, Thomas W Wainwright
OBJECTIVE: This study compares the effectiveness of a neuromuscular electrical stimulation (NMES) device and an intermittent pneumatic compression (IPC) device on enhancing microcirculatory blood flow in the thigh of healthy individuals, when stimulation is carried out peripherally at the calf. MATERIALS AND METHODS: Blood microcirculation of ten healthy individuals was recorded using laser speckle contrast imaging (LSCI) technique. A region of interest (ROI) was marked on each participant thigh...
January 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28070927/lead-sulfide-selenide-quantum-dots-and-gold-copper-alloy-nanoparticles-augment-light-harvesting-of-solar-cells
#6
Aparajita Das, Melepurath Deepa, Partha Ghosal
Lead-sulfide-selenide (PbSSe) quantum dots (QDs) and gold-copper (AuCu) alloy nanoparticles (NPs) are incorporated in a cadmium sulfide (CdS)/titanium oxide (TiO2) photoanode for the first time for enhanced conversion of solar energy to electricity. PbSSe QDs with a band gap of 1.02 eV, extend the light harvesting range of the photoanode from visible to the near infrared region. The conduction band (CB) edge of PbSSe QDs is wedged between the CBs of TiO2 and CdS; this additional level coupled with a good electrical conductivity of the dots facilitate charge transport and collection, for a high power conversion efficiency (PCE) of 4...
January 10, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28068514/interpersonal-interactions-for-haptic-guidance-during-maximum-forward-reaching
#7
S M Steinl, L Johannsen
Caregiver-patient interactions rely on interpersonal coordination (IPC) involving the haptic and visual modalities. We investigated in healthy individuals spontaneous IPC during joint maximum forward reaching. A 'contact-provider' (CP; n=2) kept light interpersonal touch (IPT) laterally with the wrist of the extended arm of a forward reaching, blind-folded 'contact-receiver' (CR; n=22). Due to the stance configuration, CP was intrinsically more stable. CR received haptic feedback during forward reaching in two ways: (1) presence of a light object (OBT) at the fingertips, (2) provision of IPT...
December 30, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28054341/intermittent-pneumatic-compression-in-combination-with-low-molecular-weight-heparin-in-the-prevention-of-venous-thromboembolic-events-in-esophageal-cancer-surgery
#8
Kevin Parry, Amir-Hossein Sadeghi, Sylvia van der Horst, Jan Westerink, Jelle P Ruurda, Richard van Hillegersberg
INTRODUCTION: Aim of this study was to evaluate the use of Intermittent Pneumatic Compression (IPC) in the prevention of symptomatic venous thromboembolic events (VTE) in patients undergoing esophagectomy for cancer. METHODS: From a prospective database, all patients operated between 2010 and 2014 received IPC in addition to LMWH and were compared to a historical cohort of patients treated LMWH only (2004-2009). RESULTS: Of the 313 included patients, 195 (62%) received IPC...
January 5, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28048671/su-f-t-104-determining-the-ntcp-parameters-of-pharyngeal-constrictors-and-proximal-esophagus-for-radiation-induced-swallowing-problems-recorded-six-months-after-radiation-therapy-for-head-and-neck-tumors
#9
P Mavroidis, A Price, M Kostich, R Amdur, W Mendenhall, N Sheets, R Green, S Das, L Marks, B Chera
PURPOSE: To estimate the radiobiological parameters of four NTCP models that describe the dose-response relations of pharyngeal constrictors and proximal esophagus regarding the severity of patient reported swallowing problems 6 months post chemo-radiotherapy. To identify the section/structure that best correlates with the manifestation of the clinical endpoints. Finally, to compare the goodness-of-fit of those models. METHODS: Forty-three patients were treated on a prospective multi-institutional phase II study for oropharyngeal squamous cell carcinoma...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046674/su-f-t-107-correlations-between-dosimetric-indices-of-pharyngeal-constrictors-and-proximal-esophagus-with-associated-patient-reported-outcomes-six-months-after-radiation-therapy-for-head-and-neck-cancer
#10
B Chera, A Price, M Kostich, R Amdur, W Mendenhall, N Sheets, R Green, L Marks, S Das, P Mavroidis
PURPOSE: To compare the correlations between different dosimetric indices derived from the pharyngeal constrictor muscles and proximal esophagus with patient-reported difficulty in swallowing 6 months post radiotherapy using a novel patient reported outcome version of CTCAE (PRO-CTCAE). METHODS: Forty-three patients with oropharyngeal squamous cell carcinoma were treated on a prospective multi-institutional study. All patients received de-intensified 60 Gy intensity modulated radiotherapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043920/altered-mir-370-expression-in-hepatic-ischemia-reperfusion-injury-correlates-with-the-level-of-nuclear-kappa-b-nf-%C3%AE%C2%BAb-related-factors
#11
Jie Zhu, Fangfang Zhu, Wenfeng Song, Bin Zhang, Xie Zhang, Xiaofeng Jin, Hong Li
BACKGROUND & AIMS: MicroRNAs (miRNAs) are a class of small endogenous, non-coding RNAs that regulate gene expression at both the transcription and translation levels. Whether miRNAs have taken part in liver ischemia-reperfusion (IR) injury was rarely reported. The purpose of this article is to investigate the potential role of miR-370 in hepatic IR injury. METHODS: Male C57BL/6 mice were divided into 5 groups (sham-operated group, I/R group, IPC group, antagomir-370 group and antagomir-NC), and the expression levels of miR-370 were assessed by quantitative real-time PCR...
December 30, 2016: Gene
https://www.readbyqxmd.com/read/28042553/remote-ischemic-preconditioning-enhances-the-expression-of-genes-encoding-antioxidant-enzymes-and-endoplasmic-reticulum-stress-related-proteins-in-rat-skeletal-muscle
#12
Ui Jun Park, Hyoung Tae Kim, Won Hyun Cho, Jae Hyoung Park, Hye Ra Jung, Min Young Kim
PURPOSE: Ischemic preconditioning (IPC), including remote IPC (rIPC) and direct IPC (dIPC), is a promising method to decrease ischemia-reperfusion (IR) injury. This study tested the effect of both rIPC and dIPC on the genes for antioxidant enzymes and endoplasmic reticulum (ER) stress-related proteins. MATERIALS AND METHODS: Twenty rats were randomly divided into the control and study groups. In the control group (n=10), the right hind limb was sham-operated. The left hind limb (IscR) of the control group underwent IR injury without IPC...
December 2016: Vascular Specialist International
https://www.readbyqxmd.com/read/28039203/ischemic-preconditioning-in-pigs-a-causal-role-for-signal-transducer-and-activator-of-transcription-3
#13
Sabine Gent, Andreas Skyschally, Petra Kleinbongard, Gerd Heusch
Ischemic preconditioning (IPC), i.e. brief episodes of non-lethal myocardial ischemia/reperfusion (IR) prior to sustained ischemia with subsequent reperfusion, reduces infarct size in all tested species so far, including humans. In rodents, the cardioprotective signal transduction causally involves an activation of AKT, ERK1/2 and STAT3. However, there are apparent species differences in the signal transduction between rodents and larger mammals such as pigs, where data on IPC's signal transduction are inconsistent for AKT and ERK1/2...
December 30, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28035392/involvement-of-dj%C3%A2-1-in-ischemic-preconditioning%C3%A2-induced-delayed-cardioprotection-in-vivo
#14
Huan Wang, Yuan-Yuan Li, Ling-Yu Qiu, Yu-Feng Yan, Zhang-Ping Liao, He-Ping Chen
DJ‑1 protein, as a multifunctional intracellular protein, has been demonstrated to serve a critical role in regulating cell survival and oxidative stress. To provide in vivo evidence that DJ‑1 is involved in the delayed cardioprotection induced by ischemic preconditioning (IPC) against oxidative stress caused by ischemia/reperfusion (I/R), the present study subjected male Sprague‑Dawley rats to IPC (3 cycles of 5‑min coronary occlusion/5‑min reperfusion) 24 h prior to I/R (30‑min coronary occlusion/120‑min reperfusion)...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28028434/infection-prevention-and-control-of-clostridium-difficile-a-global-review-of-guidelines-strategies-and-recommendations
#15
Evelyn Balsells, Teodora Filipescu, Moe H Kyaw, Camilla Wiuff, Harry Campbell, Harish Nair
BACKGROUND: Clostridium difficile is the leading cause of health care-associated infections. Given the high incidence of C. difficile infection (CDI) and the lack of primary prevention through immunization, health care professionals should be aware of the most current guidance, as well as strengths and limitations of the evidence base underpinning this guidance. METHODS: We identified publicly available national or organizational guidelines related to CDI infection and prevention control (IPC) published between 2000 and 2015 and for any health care setting through an internet search using the Google search engine...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/28024317/induction-of-nestin-early-expression-as-a-hallmark-for-mesenchymal-stem-cells-expression-of-pdx-1-as-a-pre-disposing-factor-for-their-conversion-into-insulin-producing-cells
#16
Marisela Martinez-Gamboa, Delia Elba Cruz-Vega, Jorge Moreno Cuevas, Maria Teresa Gonzalez-Garza
Diabetes constitutes a worldwide epidemic that affects all ethnic groups. Cell therapy is one of the best alternatives of treatment, by providing an effective way to regenerate insulin-producing cells lost during the course of the disease, but many issues remain to be solved. Several groups have been working in the development of a protocol capable of differentiating Mesenchymal Stem Cells (MSCs) into physiologically sound Insulin Producing Cells (IPCs). In order to obtain a simple, fast and direct method, we propose in this manuscript the induction of MSCs to express NESTIN in a short time period (2 h), proceeded by incubation in a low glucose induced medium (24 h) and lastly by incubation in a high glucose medium...
December 31, 2016: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28018915/ebola-virus-infection-among-western-healthcare-workers-unable-to-recall-the-transmission-route
#17
REVIEW
Stefano Petti, Carmela Protano, Giuseppe Alessio Messano, Crispian Scully
Introduction. During the 2014-2016 West-African Ebola virus disease (EVD) outbreak, some HCWs from Western countries became infected despite proper equipment and training on EVD infection prevention and control (IPC) standards. Despite their high awareness toward EVD, some of them could not recall the transmission routes. We explored these incidents by recalling the stories of infected Western HCWs who had no known directly exposures to blood/bodily fluids from EVD patients. Methodology. We carried out conventional and unconventional literature searches through the web using the keyword "Ebola" looking for interviews and reports released by the infected HCWs and/or the healthcare organizations...
2016: BioMed Research International
https://www.readbyqxmd.com/read/28017506/insulin-producing-cells-generation-by-overexpression-of-mir-375-in-adipose-derived-mesenchymal-stem-cells-from-diabetic-patients
#18
Mehran Piran, Seyed Ehsan Enderami, Mehrdad Piran, Hadis Soltani Sedeh, Ehsan Seyedjafari, Abdolreza Ardeshirylajimi
Diabetes Mellitus (DM) is a systematic disease, which happens because of destruction of islets of Langerhans in the pancreas and systematic resistance to insulin. The lack of donor for pancreas transplantation and risk of transplant rejection is the main challenge in the treatment of this disease. Stem cells are proper and sufficient source for creating insulin-producing cells (IPC). In this study adipose tissue was provided from diabetic patients operated for liposuction and then adipose derived stem cells (ADSCs) were isolated, characterized and then treated by lentiviruses containing miR-375, after 7, 14 and 21 days of induction, islet-like clusters (ILC) specific genes including insulin and PDX1 were evaluated by Real Time RT-PCR...
December 22, 2016: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28012598/mechanisms-underpinning-protection-against-eccentric-exercise-induced-muscle-damage-by-ischemic-preconditioning
#19
Alexander Franz, Michael Behringer, Kazunori Nosaka, Bettina Alexandra Buhren, Holger Schrumpf, Constantin Mayer, Christoph Zilkens, Moritz Schumann
Eccentric exercise training is effective for increasing muscle mass and strength, and improving insulin sensitivity and blood lipid profiles. However, potential muscle damage symptoms such as prolonged loss of muscle function and delayed onset of muscle soreness may restrict the use of eccentric exercise, especially in clinical populations. Therefore, strategies to reduce eccentric exercise-induced muscle damage (EIMD) are necessary, and an extensive number of scientific studies have tried to identify potential intervention modalities to perform eccentric exercises without adverse effects...
January 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28010906/zoonotic-disease-risk-perceptions-in-the-british-veterinary-profession
#20
Charlotte Robin, Judy Bettridge, Fiona McMaster
In human and veterinary medicine, reducing the risk of occupationally-acquired infections relies on effective infection prevention and control practices (IPCs). In veterinary medicine, zoonoses present a risk to practitioners, yet little is known about how these risks are understood and how this translates into health protective behaviour. This study aimed to explore risk perceptions within the British veterinary profession and identify motivators and barriers to compliance with IPCs. A cross-sectional study was conducted using veterinary practices registered with the Royal College of Veterinary Surgeons...
January 1, 2017: Preventive Veterinary Medicine
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