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https://www.readbyqxmd.com/read/28932492/kidney-remote-ischemic-preconditioning-as-a-novel-strategy-to-explore-the-accurate-protective-mechanisms-underlying-remote-ischemic-preconditioning
#1
Muobarak J Tuorkey
INTRODUCTION: This study reports a novel strategy for investigating the key factors responsible for the protective effect of remote ischemic preconditioning (RIPC) against renal ischemia-reperfusion (IR) injury, which remains the leading cause of the acute kidney injury that increase the morbidity and mortality in patients with renal impairment. METHODS: The renal blood flow of the right kidneys in kidney remote ischemic preconditioning (KRIPC) group was occluded for 20 min...
March 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28922051/effect-of-hospital-simulation-tutorials-on-nursing-and-pharmacy-student-perception-of-interprofessional-collaboration-findings-from-a-pilot-study
#2
Paulina Stehlik, Astrid Frotjold, Carl R Schneider
Interprofessional learning (IPL) during formal training enables interprofessional collaboration (IPC) in the workforce; however, on-campus IPL opportunities are seldom incorporated into curricula. We describe the development and implementation of two hospital simulation tutorials between nursing and pharmacy students. Students were required to provide "usual care" to a simulated patient at admission and discharge. A pre-post survey design was used to evaluate changes in Interdisciplinary Education Perception Scale (IEPS) score and student perceived educational value of the tutorials...
September 18, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28922039/teaching-and-learning-activities-to-educate-nursing-students-for-interprofessional-collaboration-a-scoping-review
#3
Natalie L Murdoch, Sheila Epp, Jeanette Vinek
To prepare new graduates with the knowledge, skills, and attitudes to engage in effective interprofessional collaboration (IPC) in practice, healthcare professional programmes need to ensure their curriculum provides opportunities for interprofessional education (IPE) and IPC. To strengthen IPE within an undergraduate curriculum and meet the professional requirements set out by regulatory bodies to prepare new graduate nurses to achieve IPC competencies, a curriculum initiative was developed to expand IPE across the four years of the Baccalaureate of Science in Nursing (BSN) programme...
September 18, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28920462/involvement-of-atrial-natriuretic-peptide-in-abrogated-cardioprotective-effect-of-ischemic-preconditioning-in-ovariectomized-rat-heart
#4
V K Vishwakarma, A Goyal, J K Gupta, P K Upadhyay, H N Yadav
BACKGROUND: Nitric oxide (NO) is an effective mediator of ischemic preconditioning (IPC)-induced cardioprotection. Atrial natriuretic peptide (ANP) is downregulated after ovariectomy, which results in reduction in the level of NO. The present study deals with the investigation of the role of ANP in abrogated cardioprotective effect of IPC in the ovariectomized rat heart. METHODS: Heart was isolated from ovariectomized rat and mounted on Langendorff's apparatus, subjected to 30 min of ischemia and 120 min of reperfusion...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28918023/repression-of-coup-tfi-improves-bone-marrow-derived-mesenchymal-stem-cell-differentiation-into-insulin-producing-cells
#5
Tao Zhang, Xiao-Hang Li, Dian-Bao Zhang, Xiao-Yu Liu, Feng Zhao, Xue-Wen Lin, Rui Wang, Hong-Xin Lang, Xi-Ning Pang
Identifying molecular mechanisms that regulate insulin expression in bone marrow-derived mesenchymal stem cells (bmMSCs) can provide clues on how to stimulate the differentiation of bmMSCs into insulin-producing cells (IPCs), which can be used as a therapeutic approach against type 1 diabetes (T1D). As repression factors may inhibit differentiation, the efficiency of this process is insufficient for cell transplantation. In this study, we used the mouse insulin 2 (Ins2) promoter sequence and performed a DNA affinity precipitation assay combined with liquid chromatography-mass spectrometry to identify the transcription factor, chicken ovalbumin upstream promoter transcriptional factor I (COUP-TFI)...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28916636/electrophysiological-heterogeneity-of-pacemaker-cells-in-rabbit-intercaval-region-including-sa-node-insights-from-recording-multiple-ion-currents-in-each-cell
#6
Oliver Monfredi, Kenta Tsutsui, Bruce D Ziman, Michael D Stern, Edward G Lakatta, Victor A Maltsev
Cardiac pacemaker cells, including cells of the sinoatrial node, are heterogeneous in size, morphology and electrophysiological characteristics. The exact extent to which these cells differ electrophysiologically is unclear, yet is critical to understanding their functioning. We examined major ionic currents in individual intercaval pacemaker cells (IPC) sampled from the para-cristal, inter-caval region (including the sinoatrial node) that were spontaneously beating after enzymatic isolation from rabbit hearts...
September 15, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28903412/acute-atorvastatin-treatment-restores-the-cardioprotective-effects-of-ischemic-postconditioning-in-hyperlipidemic-rats
#7
Tao Sun, Hong-Ju Zhang, Chayakrit Krittanawong, Su Wang, Ying Tao, Zhao Li, Qiancheng Yin, Donghua Zhang, Qian Wang, Ji Huang, Jingmei Zhang, Zhizhong Li, Yutong Cheng
BACKGROUND: Ischemic Postconditioning (IPC) reduces ischemia/reperfusion (I/R) injury under normal conditions. HMG-CoA reductase inhibitors (statins), which inhibit the synthesis of mevalonate, can interfere with the cardioprotective effect of IPC. However, the beneficial role of IPC in hyperlipidemic patients, post-acute administration of statins remains unknown. This study was to determine if acute administration of atorvastatin affect the infarct size-limiting effect of IPC in hyperlipidemic rats...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901579/formation-and-photodynamic-behavior-of-transition-metal-dichalcogenide-nanosheet-fullerene-inorganic-organic-nanohybrids-on-semiconducting-electrodes
#8
Jinseok Baek, Tomokazu Umeyama, Wookjin Choi, Yusuke Tsutsui, Hiroki Yamada, Shu Seki, Hiroshi Imahori
Composite films consisting of C60 and well-exfoliated nanosheets of transition metal dichalcogenides (TMDs), i.e., MoS2 or WS2, with a bulk heterojunction structure were facilely fabricated onto a semiconducting SnO2 electrode via a two-step methodology; self-assembly into their composite aggregates by injecting poor solvent into good solvent with the dispersion and subsequent electrophoretic deposition. Photoexcitation of the composites on SnO2 exhibited enhanced transient conductivities in comparison with single components of TMDs or C60, demonstrating that the bulk heterojunction nanostructure of TMD and C60 promoted the charge separation (CS)...
September 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28892718/insight-into-the-effects-of-modifying-chromophores-on-the-performance-of-quinoline-based-dye-sensitized-solar-cells
#9
Mao Mao, Jian-Bo Wang, Xiu-Lin Liu, Guo-Hua Wu, Xia-Qin Fang, Qin-Hua Song
A series of organic dyes based on quinoline as an electron-deficient π-linker, were designed and synthesized for dye sensitized solar cells (DSSC) application. These push-pull conjugated dyes, sharing same anchoring group with distinctive electron-rich donating groups such as N,N-diethyl (DEA-Q), 3,6-dimethoxy carbazole (CBZ-Q), bis(4-butoxyphenyl)amine (BPA-Q), were synthesized by Riley oxidation of CH3 followed by Knoevenagel condensation of the corresponding aldehyde precursors 2a-c with cyanoacrylic acid...
September 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28890982/the-solution-phase-process-of-a-g-c3n4-bivo4-dyad-to-a-large-area-photoanode-interfacial-synergy-for-highly-efficient-water-oxidation
#10
Bing Zhang, Shu-Yu Zhao, Hong-Hui Wang, Tian-Jian Zhao, Yong-Xing Liu, Li-Bing Lv, Xiao Wei, Xin-Hao Li, Jie-Sheng Chen
The oxygen evolution reaction (OER) is the rate-limiting process for water splitting, and highly efficient large-area OER photoanodes have been considered as an essential part in photoelectrochemical water splitting reactors. The high hole-electron separation efficiency of photoanodes is highly required for real applications of photoanodes in sufficiently harvesting solar energy. Herein we show that the inactive g-C3N4 nanolayers can be self-assembled with BiVO4 into a highly coupled BV/CN dyad to significantly enhance the charge separation efficiency of BiVO4 photoelectrodes for the OER...
September 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28890040/risk-of-deep-vein-thrombosis-in-neurosurgery-state-of-the-art-on-prophylaxis-protocols-and-best-clinical-practices
#11
REVIEW
Mario Ganau, Lara Prisco, Helene Cebula, Julien Todeschi, Houssem Abid, Gianfranco Ligarotti, Raoul Pop, Francois Proust, Salvatore Chibbaro
OBJECTIVE: To analytically discuss some protocols in Deep vein thrombosis (DVT)/pulmonary Embolism (PE) prophylaxis currently use in Neurosurgical Departments around the world. DATA SOURCES: Analysis of the prophylaxis protocols in the English literature: An analytical and narrative review of literature concerning DVT prophylaxis protocols in Neurosurgery have been conducted by a PubMed search (back to 1978). DATA EXTRACTION: 80 abstracts were reviewed, and 74 articles were extracted...
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28888800/percutaneous-lung-ablation-of-pulmonary-recurrence-may-improve-survival-in-selected-patients-undergoing-cytoreductive-surgery-for-colorectal-cancer-with-peritoneal-carcinomatosis
#12
T A Bin Traiki, O M Fisher, S J Valle, R N Parikh, M A Kozman, D Glenn, M Power, W Liauw, N A Alzahrani, D L Morris
PURPOSE: To analyze the outcomes of patients developing pulmonary metastases (PM) following cytoreductive surgery (CRS) and perioperative intra-peritoneal chemotherapy (IPC) for colorectal cancer (CRC) with peritoneal carcinomatosis. PATIENTS AND METHODS: A retrospective analysis of patients undergoing CRS/IPC for CRC from 1996 to 2016 was performed. Lung-specific disease-free and patient overall survival was analyzed. Patients undergoing percutaneous lung ablative therapy (PLAT) for PM were compared to patients receiving systemic chemotherapy alone...
August 31, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28887239/atorvastatin-protect-kidney-from-remote-reperfusion-injury
#13
Carlos Henrique Marques Dos Santos, Doroty Mesquita Dourado, Baldomero Antonio Kato da Silva, Henrique Budib Dorsa Pontes, Euler de Azevedo Neto, Giovanna Serra da Cruz Vendas, Ian de Oliveira Chaves, João Victor Cunha Miranda, João Victor Durães Gomes Oliva, Letícia do Espirito Santo Dias, Murillo Henrique Martins de Almeida, Trícia Luna Sampaio
BACKGROUND: There is a need to find an effective treatment against reperfusion injury. The aim of the present study was to evaluate the capacity of the ischemic postconditioning and statin to prevent renal reperfusion injury. DESIGN AND SETTING: An experimental study developed at Universidade Anhanguera-Uniderp. METHODS: A total of 41 Wistar rats were distributed into 5 groups: ischemia and reperfusion (I/R), ischemic postconditioning (IPC), postconditioning + statin (IPC + S), statin (S) and Sham...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28879550/new-protocol-based-on-uhplc-ms-ms-for-quantitation-of-metabolites-in-xylose-fermenting-yeasts
#14
Christiane Gonçalves Campos, Henrique César Teixeira Veras, José Antônio de Aquino Ribeiro, Patrícia Pinto Kalil Gonçalves Costa, Katiúscia Pereira Araújo, Clenilson Martins Rodrigues, João Ricardo Moreira de Almeida, Patrícia Verardi Abdelnur
Xylose fermentation is a bottleneck in second-generation ethanol production. As such, a comprehensive understanding of xylose metabolism in naturally xylose-fermenting yeasts is essential for prospection and construction of recombinant yeast strains. The objective of the current study was to establish a reliable metabolomics protocol for quantification of key metabolites of xylose catabolism pathways in yeast, and to apply this protocol to Spathaspora arborariae. Ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) was used to quantify metabolites, and afterwards, sample preparation was optimized to examine yeast intracellular metabolites...
September 6, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28879549/decreased-platelet-count-in-children-with-epilepsy-treated-with-valproate-and-its-relationship-to-the-immature-platelet-fraction
#15
Hirokazu Kurahashi, Akiyoshi Takami, Kenta Murotani, Shingo Numoto, Akihisa Okumura
This study examined relationships between valproate (VPA) and platelet count and immature platelet fraction (IPF). We compared the platelet count and IPF among three groups of children: those treated with VPA, those treated with other antiepileptic drugs (AEDs), and a reference group. IPF was measured using flow cytometry, and absolute immature platelet count (A-IPC) was calculated. The platelet count was significantly lower in the VPA group than in other AED and reference groups. In all groups, IPF was negatively correlated with platelet count...
September 6, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28876142/contributions-of-team-climate-in-the-study-of-interprofessional-collaboration-a-conceptual-analysis
#16
Heloise F Agreli, Marina Peduzzi, Christopher Bailey
The concept of team climate is widely used to understand and evaluate working environments. It shares some important features with Interprofessional Collaboration (IPC). The four-factor theory of climate for work group innovation, which underpins team climate, could provide a better basis for understanding both teamwork and IPC. This article examines in detail the common ground between team climate and IPC, and assesses the relevance of team climate as a theoretical approach to understanding IPC. There are important potential areas of overlap between team climate and IPC that we have grouped under four headings: (1) interaction and communication between team members; (2) common objectives around which collective work is organised; (3) responsibility for performing work to a high standard; and (4) promoting innovation in working practices...
September 6, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28875558/spinal-cord-stimulator-explantation-motives-for-removal-of-surgically-placed-paddle-systems
#17
Derrick A Dupré, Nestor Tomycz, Donald Whiting, Michael Oh
BACKGROUND: Despite requiring successful trials prior to implantation, spinal cord stimulation (SCS) systems for pain are often later removed. Removing surgically implanted hardware subjects patients to the risks and discomfort of a second surgery, threatens the cost-effectiveness of SCS, and limits the perceived durability of SCS technology for pain problems. OBJECTIVE: To investigate patterns of reasons given among patients who underwent SCS explant surgery (SCSES)...
September 5, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28874433/an-emerging-multidrug-resistant-bacteria
#18
Jennie Johnstone, Samir N Patel
No abstract text is available yet for this article.
September 5, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28865245/the-sh2b3-and-kcnk5-loci-may-be-implicated-in-regulation-of-platelet-count-volume-and-maturity
#19
Morten K Christiansen, Sanne B Larsen, Mette Nyegaard, Søs Neergaard-Petersen, Morten Würtz, Erik L Grove, Anne-Mette Hvas, Henrik K Jensen, Steen D Kristensen
INTRODUCTION: In recent genome-wide association studies, coronary artery disease (CAD) and myocardial infarction (MI) have been linked to a number of genetic variants, but their role in thrombopoiesis is largely unknown. AIM: We investigated the association between CAD and MI-associated genetic variants and five thrombopoiesis-related indices: platelet count (PC), mean platelet volume (MPV), immature platelet count (IPC), immature platelet fraction (IPF), and serum thrombopoietin (TPO)...
August 18, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28864054/quality-gaps-and-comparative-effectiveness-of-management-strategies-for-recurrent-malignant-pleural-effusions
#20
David E Ost, Jiangong Niu, Hui Zhao, Horiana B Grosu, Sharon H Giordano
BACKGROUND: Guidelines for recurrent malignant pleural effusions (MPE) recommend definitive procedures, such as indwelling pleural catheters (IPC) or pleurodesis, over repeat thoracentesis. We hypothesized that many patients have multiple thoracenteses rather than definitive procedures and that this results in more procedures and complications. METHODS: Retrospective cohort study using SEER-Medicare data from 2007-2011. Patients age 66-90 with a MPE were included...
August 29, 2017: Chest
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