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https://www.readbyqxmd.com/read/28811322/analysis-of-sphingolipids-sterols-and-phospholipids-in-human-pathogenic-cryptococcus-strains
#1
Ashutosh Singh, Andrew MacKenzie, Geoffrey Girnun, Maurizio Del Poeta
Cryptococcus species cause invasive infections in humans. Lipids play an important role in the progression of these infections. Independent studies done by our group and others provide some detail about the functions of these lipids in Cryptococcus infections. However, pathways of biosynthesis and metabolism of these lipids are not completely understood. To thoroughly understand the physiological role of these Cryptococcus lipids, a proper structure and composition analyses of Cryptococcus lipids is demanded...
August 15, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28810743/layer-by-layer-molecular-assemblies-for-dye-sensitized-pho-toelectrosynthesis-cells-prepared-by-atomic-layer-deposi-tion
#2
Degao Wang, Matthew V Sheridan, Bing Shan, Byron H Farnum, Seth L Marquard, Benjamin D Sherman, Michael S Eberhart, Animesh Nayak, Christopher Dares, Atanu Das, R Morris Bullock, Thomas J Meyer
In a Dye Sensitized Photoelectrosynthesis Cell (DSPEC) the relative orientation of the catalyst and chromophore plays an important role in determining the device efficiency. Here we introduce a new, robust atomic layer deposition (ALD) procedure for the preparation of molecular chromophore-catalyst assemblies on wide bandgap semiconductors. In this procedure, solution deposited, phosphonate derivatized metal complexes on metal oxide surfaces are treated with reactive metal reagents in the gas phase by ALD to form an outer metal ion bridging group which can bind a second phosphonate containing species from solution to establish a R1-PO2-O-M-O-PO2-R2 type surface assembly...
August 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28800132/sphingolipid-accumulation-causes-mitochondrial-dysregulation-and-cell-death
#3
Jeffrey Knupp, Fernando Martinez-Montañés, Francoise Van Den Bergh, Stephanie Cottier, Roger Schneiter, Daniel Beard, Amy Chang
Sphingolipids are structural components of cell membranes that have signaling roles to regulate many activities, including mitochondrial function and cell death. Sphingolipid metabolism is integrated with numerous metabolic networks, and dysregulated sphingolipid metabolism is associated with disease. Here, we describe a monogenic yeast model for sphingolipid accumulation. A csg2Δ mutant cannot readily metabolize and accumulates the complex sphingolipid inositol phosphorylceramide (IPC). In these cells, aberrant activation of Ras GTPase is IPC-dependent, and accompanied by increased mitochondrial reactive oxygen species (ROS) and reduced mitochondrial mass...
August 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28793040/the-role-of-ischemic-preconditioning-and-pentoxifylline-in-intestinal-ischemia-reperfusion-injury-of-rats
#4
Teresinha Regina Ribeiro de Oliveira, Geraldo Ferreira de Oliveira, Ricardo Santos Simões, Eduardo Hiroshi Tikazawa, Hugo Pequeno Monteiro, Djalma José Fagundes, Murched Omar Taha
Purpose: To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR). Methods: Thirty rats were assigned to 5 groups (N=6): (CG): no clamping of the superior mesenteric artery (90 min.); (IR-SS): saline + ischemia (30 min.) + reperfusion (60 min.); (IR-PTX): PTX + ischemia (30min.) + reperfusion (60 min.); (IPC-IR-SS): 5 min. of ischemia + 5 minutes of reperfusion (IPC) + saline + ischemia (30 min...
July 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28791800/low-recombination-thieno-3-4-b-thiophene-based-photosensitizers-for-dscs-with-panchromatic-ipce-responses
#5
Phillip Brogdon, Hammad Cheema, Jared Heath Delcamp
We report four NIR photosensitizers employing a low-recombination donor and a thieno[3,4-b]thiophene (3,4-TT) π-bridge for use in dye-sensitized solar cells. The inclusion of electron rich π-spacers red-shifts the dye absorbance with solution absorption onsets reaching 700 nm. Dyes were found to have suitable energy levels for rapid electron transfers via cyclic voltammetry and UV-Vis-NIR absorption spectroscopy. Computationally optimized ground-state geometries show an increased torsional angle between π-spacer and π-bridge brought about by an added alkyl chain resulting in a widened optical band gap and increased oxidation potentials due to a weakening of the electron accepting ability of 3,4-TT for solution measurements...
August 8, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28783502/which-characteristics-of-planning-matter-individual-and-dyadic-physical-activity-plans-and-their-effects-on-plan-enactment
#6
Jan Keller, Lena Fleig, Diana Hilda Hohl, Amelie U Wiedemann, Silke Burkert, Aleksandra Luszczynska, Nina Knoll
OBJECTIVE: Past research supports individual planning as an effective intervention strategy to increase physical activity in individuals. A similar strategy, dyadic planning, adds a planning partner who supports an individual's planning processes. Whether the two planning formats differ in terms of participants' entered plan content and whether and how different content characteristics are linked to plan enactment remains unknown. By investigating the content of generated plans, this study aimed at distinguishing plan characteristics of the two planning formats and examining their role as predictors of later plan enactment...
July 31, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28770654/effects-of-intermittent-pneumatic-compression-on-leg-vascular-function-in-people-with-spinal-cord-injury-a-pilot-study
#7
Daniel P Credeur, Lena M Vana, Edward T Kelley, Lee Stoner, David R Dolbow
Objective The purpose of this pilot study was to determine whether 60 mins of intermittent pneumatic compression therapy (IPC) could acutely increase leg blood flow-induced shear stress and enhance vascular endothelial function in persons with spinal cord injury (SCI). Design Pretest with multiple posttests, within subject randomized control design. Setting University of Southern Mississippi, Spinal Cord Injury Research Program within the School of Kinesiology, recruiting from the local community in Hattiesburg, Jackson, and Gulfport, MS...
August 3, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28764176/infiltrating-ductal-carcinoma-co-existing-with-intraductal-papillary-carcinoma-of-male-breast-a-rare-case-report
#8
Mayank Kumar, Bhaswanth Pottipati, Surekha U Arakeri, Anita P Javalgi
Male breast carcinomas are rare tumours, accounting for less than 1% of all malignancies in men. Intracystic Papillary Carcinoma (IPC) in males is a very rare entity, representing 5-7.5% of all male breast carcinomas. It lacks the classical clinical, radiological and cytological features of malignancy and usually presents as a benign-appearing lump. We report a case of Infiltrating Ductal Carcinoma (IDC) co-existing with intracystic papillary carcinoma in a 53-year-old male who presented with lump in the right breast...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28761713/the-effect-of-1-week-of-repeated-ischaemic-leg-preconditioning-on-simulated-keirin-cycling-performance-a-randomised-trial
#9
Angus Lindsay, Carl Petersen, Gavin Blackwell, Hamish Ferguson, Greg Parker, Nina Steyn, Steven P Gieseg
BACKGROUND: Coaches continually seek new ways of doing things and also refine existing techniques to improve sporting performance. Coaches are currently experimenting using ischaemic preconditioning (IPC) over consecutive days in the hope of improving competitive performances. AIMS: First, to quantify the physiological impact of 1 week of IPC on simulated Keirin cycling performance. Second, to investigate if biochemical stress markers are affected over the treatment period...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28759315/tonometry-of-deep-tissues-for-setting-effective-compression-pressures-in-lymphedema-of-limbs
#10
Marzanna T Zaleska, Waldemar L Olszewski, Marek Durlik, Mariusz K Kaczmarek, Bob Freidenrich
BACKGROUND: The therapeutic intermittent pneumatic compression (IPC) pressures are usually set arbitrarily at levels between 40 and 60 mmHg. However, it is not known how much force has been transferred to edema fluid. There is a need to know how high edema fluid pressures should be generated to evacuate the stagnant fluid. The externally applied compression force dissipates in hard tissues and only a portion of it is conveyed to tissue fluid. Simultaneous measuring of compression force using deep tissue tonometry and recording edema fluid pressures under a tonometer would give hints of how high should therapist or patient set IPC pressures to mobilize fluid...
July 31, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28759307/evaluation-of-stiffness-in-postmastectomy-lymphedema-using-acoustic-radiation-force-impulse-imaging-a-prospective-randomized-controlled-study-for-identifying-the-optimal-pneumatic-compression-pressure-to-reduce-stiffness
#11
Soo Kyung Bok, Yumi Jeon, Jin A Lee, So Young Ahn
PURPOSE: We aimed to assess the improvement in stiffness in patients with postmastectomy lymphedema (PMLE) after intermittent pneumatic compression (IPC) using acoustic radiation force impulse (ARFI) imaging and evaluate the effects of different IPC pressures. METHODS: We randomly assigned 45 patients with PMLE (stage II) to three groups based on the IPC pressure: 25, 35, and 45 mmHg. Patients received a single session of IPC for 30 minutes. We recorded the subcutaneous tissue thickness of the proximal upper limbs using ultrasonography and circumference of the upper limbs and stiffness using ARFI before and immediately after IPC...
July 31, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28748196/developing-interactive-antimicrobial-stewardship-and-infection-prevention-curricula-for-diverse-learners-a-tailored-approach
#12
Priya Nori, Theresa Madaline, Iona Munjal, Shubha Bhar, Yi Guo, Susan K Seo, Andrea Porrovecchio, Elizabeth Gancher, Joshua Nosanchuk, Liise-Anne Pirofski, Belinda Ostrowsky
BACKGROUND: To impart principles of antimicrobial stewardship (AS) and infection prevention and control (IPC), we developed a curriculum tailored to the diverse aptitudes of learners at our medical center. METHODS: We integrated case-based modules, group learning activities, smartphone applications (apps), decision support tools, and prescription audit and feedback into curricula of the medical school, medicine residency program, infectious diseases (ID) fellowship program, and hospital medicine program operations...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28741401/trans-diagnostic-comparison-of-response-inhibition-in-tourette-s-disorder-and-obsessive-compulsive-disorder
#13
Siyan Fan, Danielle C Cath, Ysbrand D van der Werf, Stella de Wit, Dick J Veltman, Odile A van den Heuvel
OBJECTIVES: Impaired response inhibition is related to neurodevelopmental disorders, such as Tourette's disorder (TD) and obsessive-compulsive disorder (OCD). Unlike OCD, in which neural correlates of response inhibition have been extensively studied, TD literature is limited. By using a Stop-Signal task, we investigated the neural mechanisms underlying response inhibition deficits in TD compared to OCD and healthy controls (HCs). METHODS: Twenty-three TD patients, 20 OCD patients and 22 HCs were scanned (3T MRI)...
July 25, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28736742/unique-morphological-characteristics-of-mitochondrial-subtypes-in-the-heart-the-effect-of-ischemia-and-ischemic-preconditioning
#14
Siavash Beikoghli Kalkhoran, Peter Munro, Fan Qiao, Sang-Bing Ong, Andrew R Hall, Hector Cabrera-Fuentes, Bibhas Chakraborty, William A Boisvert, Derek M Yellon, Derek J Hausenloy
RATIONALE: Three subsets of mitochondria have been described in adult cardiomyocytes - intermyofibrillar (IMF), subsarcolemmal (SSM), and perinuclear (PN). They have been shown to differ in physiology, but whether they also vary in morphological characteristics is unknown. Ischemic preconditioning (IPC) is known to prevent mitochondrial dysfunction induced by acute myocardial ischemia/reperfusion injury (IRI), but whether IPC can also modulate mitochondrial morphology is not known. AIMS: Morphological characteristics of three different subsets of adult cardiac mitochondria along with the effect of ischemia and IPC on mitochondrial morphology will be investigated...
January 2017: Discoveries
https://www.readbyqxmd.com/read/28732739/environmental-scan-of-infection-prevention-and-control-practices-for-containment-of-hospital-acquired-infectious-disease-outbreaks-in-acute-care-hospital-settings-across-canada
#15
Wrechelle Ocampo, Rose Geransar, Nancy Clayden, Jessica Jones, Jill de Grood, Mark Joffe, Geoffrey Taylor, Bayan Missaghi, Craig Pearce, William Ghali, John Conly
BACKGROUND: Ward closure is a method of controlling hospital-acquired infectious diseases outbreaks and is often coupled with other practices. However, the value and efficacy of ward closures remains uncertain. PURPOSE: To understand the current practices and perceptions with respect to ward closure for hospital-acquired infectious disease outbreaks in acute care hospital settings across Canada. METHODS: A Web-based environmental scan survey was developed by a team of infection prevention and control (IPC) experts and distributed to 235 IPC professionals at acute care sites across Canada...
July 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28732362/acute-atorvastatin-treatment-restores-the-cardioprotective-effects-of-ischemic-postconditioning-in-hyperlipidemic-rats
#16
Tao Sun, Hong-Ju Zhang, Chayakrit Krittanawong, Su Wang, Ying Tao, Zhao Li, Qiancheng Yin, Donghua Zhang, Qian Wang, Ji Huang, Jingmei Zhang, Zhizhong Li, Yutong Cheng
BACKGROUND: Ischemic Postconditioning (IPC) reduces ischemia/reperfusion (I/R) injury under normal conditions. HMG-CoA reductase inhibitors (statins), which inhibit the synthesis of mevalonate, can interfere with the cardioprotective effect of IPC. However, the beneficial role of IPC in hyperlipidemic patients, post-acute administration of statins remains unknown. This study was to determine if acute administration of atorvastatin affect the infarct size-limiting effect of IPC in hyperlipidemic rats...
July 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28730204/electronic-and-charge-transfer-properties-of-bio-inspired-flavylium-ions-for-applications-in-tio2-based-dye-sensitized-solar-cells
#17
Giuseppe Calogero, Ilaria Citro, Gaetano Di Marco, Stefano Caramori, Laura Casarin, Carlo Alberto Bignozzi, João Avó, A Jorge Parola, Fernando Pina
We present here a complete study on four synthetic environmentally friendly flavylium salts employed as sensitizers for dye-sensitized solar cells (DSSCs). The effect of several donor groups on the molecular structure of flavylium ions was investigated by combining electrochemical, spectroscopic and computational means. The computational investigation indicated that these molecules can interact strongly with the TiO2 surface by a single OH group of the dihydroxybenzene moiety, and can efficiently inject electrons into the TiO2 following the excitation of their lowest singlet states exhibiting charge transfer (CT) character...
July 21, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28730074/protection-of-retinal-ganglion-cells-against-optic-nerve-injury-by-induction-of-ischemic-preconditioning
#18
Xia Liu, Jiu-Ping Liang, Ou Sha, Song-Juan Wang, Heng-Guo Li, Eric Y P Cho
AIM: To explore if ischemic preconditioning (IPC) can enhance the survival of retinal ganglion cells (RGCs) after optic nerve axotomy. METHODS: Twenty-four hours prior to retinal ischemia 60min or axotomy, IPC was applied for ten minutes in groups of (n=72) animals. The survival of RGCs, the cellular expression of heat shock protein 27 (HSP27) and heat shock protein 70 (HSP70) and the numbers of retinal microglia in the different groups were quantified at 7 and 14d post-injury...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28727692/short-term-outcomes-following-cytoreductive-surgery-and-heated-intra-peritoneal-chemotherapy-at-waikato
#19
Ngov Jasen Ly, Linus Wu, Ralph Van Dalen, Simione Lolohea
AIM: Pseudomyxoma peritonei is a rare disease that affects 1-2 per million population per year. Treatment with cytoreductive surgery with heated intraperitoneal chemotherapy (CRS with IPC) has been well described. The purpose of this study was to look at the short-term outcomes following CRS with IPC for all such patients treated in Waikato. METHOD: Records for all patients presenting to surgery for CRS with IPC were retrospectively reviewed. CRS with IPC was performed in accordance with the techniques described by Sugarbaker...
July 21, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28727323/indocyanine-green-near-infrared-lymphangiography-for-evaluation-of-effectiveness-of-edema-fluid-flow-under-therapeutic-compression
#20
Marzanna T Zaleska, Waldemar L Olszewski
The commonly used modalities for therapy of limb lymphedema are manual lymphatic drainage, manual devices moving edema fluid and intermittent pneumatic compression (IPC). What seems to be necessary for validation of the effect of the compression procedure is imaging of the mobilized moving edema fluid. Picture of edema fluid flow would allow the therapist to use force adjusted to the tissue volume and stiffness differing in various limb regions as well as identify sites of abundant accumulation of fluid requiring more compression...
July 20, 2017: Journal of Biophotonics
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