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Wen-Ze Qiu, Hao-Cheng Yang, Zhi-Kang Xu
Mussel-inspired chemistry based on polydopamine (PDA) deposition has been developed as a facile and universal method for the surface modification of various materials. However, the inherent shortcomings of PDA coatings still impede their practical applications in the development of functional materials. In this review, we introduce the recent progress in the emerging dopamine-assisted co-deposition as a one-step strategy for functionalizing PDA-based coatings, and improving them in the aspects of deposition rate, morphology uniformity, surface wettability and chemical stability...
April 27, 2018: Advances in Colloid and Interface Science
Anh-Vy Tran, KyuHwan Shim, Thu-Thao Vo Thi, Jeong-Keun Kook, Seong Soo A An, Sang-Wha Lee
This study demonstrated the targeted delivery and controlled release of cisplatin drug molecules from doubly decorated mesoporous silica nanoparticles (MSNs), which were internally grafted with fluorescent conjugates and externally coated with polydopamine (PDA) and graphene oxide (GO) layers. The brush-like internal conjugates conferred fluorescent functionality and high capacity of cisplatin loading into MSNs, as well as contributing to a sustained release of the cisplatin through a porous channel with the assistance of external PDA layer...
May 15, 2018: Acta Biomaterialia
Cheol Am Hong, Ho Yeon Son, Yoon Sung Nam
For tissue engineering applications, small interfering RNA (siRNA) is an attractive agent for controlling cellular functions and differentiation. Although polyionic condensation of nucleic acids with polycations has been widely used for gene delivery, siRNA is not strongly associated with cationic carriers due to its low charge density and rigid molecular structures. The use of an excess amount of cationic carriers is often used for siRNA condensation, though they can induce severe cytotoxicity. Here we introduce the self-assembly of siRNA with mild polyelectrolytes into multilayers for efficient gene silencing during cell proliferation...
May 17, 2018: Scientific Reports
Liucan Wang, Haidi Guan, Zhenqiang Wang, Yuxin Xing, Jixi Zhang, Kaiyong Cai
Combination chemotherapy with a modulator and a chemotherapeutic drug has become one of the most promising strategies for the treatment of multidrug resistance (MDR) in cancer therapy. However, the development of nanocarriers with a high payload and sequential release of therapeutic agents poses a significant challenge. In this work, we report a type of hybrid nanocarriers prepared by polydopamine (PDA) mediated integration of the mesoporous MSN core and the microporous zeolite imidazolate frameworks-8 (ZIF-8) shell...
May 16, 2018: Molecular Pharmaceutics
Meihua Hu, Pengcheng Huang, Lili Suo, Fangying Wu
A polydopamine-based molecularly imprinted polymer was deposited on the surface of magnetite (ferroferric oxide) nanoparticles (Fe3 O4 @PDA MIPs) and is shown to be an efficient and fairly specific sorbent for the extraction of various ochratoxins. The MIPs were characterized by IR spectroscopy and transmission electron microscopy. The adsorption capacities, evaluated through the langmuir adsorption isotherm model, are 1.8, 0.23 and 0.17 mg·g-1 for ochratoxin A, ochratoxin B and ochratoxin C, respectively...
May 15, 2018: Mikrochimica Acta
Weibo Zhang, Shuang Wang, Shaohua Ge, Jialong Chen, Ping Ji
Biomedical device-associated infection (BAI) and lack of osseointegration are the main causes of implant failure. Therefore, it is imperative for implants not only to depress microbial activity and biofilm colonization but also to prompt osteoblast functions and osseointegration. As part of the coating development for implants, the interest of in vitro studies on the interaction between implant substrate morphology and the coating's biological performances is growing. In this study, by harnessing the adhesion and reactivity of bioinspired polydopamine, nano-silver was successfully anchored onto micro/nanoporous as well as smooth titanium surfaces to analyse the effect of substrate morphology on biological performances of the coatings...
April 2018: Royal Society Open Science
JingHong Li, Nan Chen, YiPing Tian, Hui Xu
The exploration of volatile organic compounds (VOCs) produced by cell lines may be a powerful and non-invasive tool for the study of the health risk of human exposure to atmospheric particulate matter (PM). In this work, we developed a sensitive solid phase microextraction-gas chromatography-mass spectrometry method (SPME-GC-MS) to analyze VOCs in breathed gas of PM2.5-induced human embryonic fibroblast cell line (MRC-5). A novel graphene oxide/polyaniline/polydopamine (GO/PANI/PDA) coating was prepared on a stainless steel wire via electrochemical deposition and self-polymerization for the first time...
August 1, 2018: Talanta
Fengxia Chang, Yang Yang, Xia Xie, Meixian Li, Zhiwei Zhu
The modification of inner surface has significant influence in the properties of the nano or microchannel based on various materials, especially for the ionic current rectification (ICR) that arises from the selective interaction between ions in solution and the inner surface. Herein, we demonstrate a simple strategy to asymmetrically modify the inner wall of a glassy biconical microchannel with silver, copper or gold by means of silver mirror reaction and polydopamine platform, respectively. And the bidirectional ionic current rectification phenomena were observed in all of the modified biconical microchannels...
August 1, 2018: Talanta
Yong-Yan Zhao, Xue-Feng Cheng, Wen-Hu Qian, Jin Zhou, Jing-Hui He, Hua Li, Qing-Feng Xu, Na-Jun Li, Dong-Yun Chen, Jian-Mei Lu
In recent years, numerous organic molecules and polymers carrying various functional groups were synthesized and used in fabrication of wearable electronic devices. Compared to previous materials suffer from poisonousness, stiffness and complex film fabrication, we circumvent above matters by taking advantage of mussel-inspired polydopamine as our active material to realize random resistive access memories (RRAMs). Polydopamine thin film were grown on indium tin oxide glass catalyzed by Cu2SO4/H2O2 and characterized by Fourier infrared spectroscope (FT-IR), Ultra-violet (UV-Vis) and scanning electron microscope...
May 14, 2018: Chemistry, An Asian Journal
Minhui Hu, Xidong Lin, Rongkang Huang, Keli Yang, Yeru Liang, Xingcai Zhang, Hui Wang, Dingcai Wu
Ventral hernia is a public health issue and millions of meshes are used to repair abdominal wall defects every year. Polypropylene-based composite meshes represent an important class of materials for intraperitoneal repair, but the meshes generally give rise to infection, seroma, migration, and adhesion, leading to severe consequence or even reoperation. Here, a facile and versatile one-way fabrication of lightweight, highly permeable, and biocompatible composite meshes with superior antiadhesion properties is proposed by modifying polypropylene meshes with well-defined polydopamine nanocoating...
May 14, 2018: Macromolecular Bioscience
Pengfei Wei, Zuoying Yuan, Qing Cai, Jianping Mao, Xiaoping Yang
Bone defect repair, especially in terms of infection, remains a big challenge in clinical therapy. To meet clinical requirements, the dual-functional strategy including antibacterial activity and strong osteogenesis effect is a promising approach in bone tissue engineering. In the present study, bioresorbable porous-structured microspheres are fabricated from amphiphilic block copolymer composed of poly(l-lactide) and poly(ethyl glycol) blocks. After being surface coated with mussel-inspired polydopamine, the microspheres are loaded with nanosilver via reduction of silver nitrate and apatite via biomineralization in sequence...
May 11, 2018: Macromolecular Rapid Communications
Xinghuan Liu, Junjie Kang, Yiqing Wang, Wei Li, Heling Guo, Liang Xu, Xuhong Guo, Feng Zhou, Xin Jia
Dopamine (DA) polymerization has received significant attention in many fields, however, almost all of the works are limited to aqueous solution and hamper its wide application. This paper reports that amines can trigger DA polymerization by capturing the H+ from DA hydrochloride and intermediates to accelerate the generation of radical species in water or organic solvents. Increasing concentration and decreasing pKb of amines cause the reaction equilibrium to shift toward the product polydopamine (PDA). Water-soluble and easily-removable Na2 SO4 nanowires and NaCl cubes can be used as templates to prepare different morphologies of hollow PDA structures by DA polymerization in ethanol solution...
May 11, 2018: Macromolecular Rapid Communications
Ravikumar A, Panneerselvam P
We describe a highly sensitive fluorescence biosensor incorporating polydopamine nanotubes (PDNTs) based on the mechanism of exonuclease III (Exo III) assisted signal amplification for the determination of Hg2+ in aqueous solution. Fluorescent probes of FAM labeled ssDNA (FAM-ssDNA) adsorbed on the PDNTs act as an efficient quencher. In the presence of Hg2+, the FAM-ssDNA can bind to Hg2+ to form double stranded DNA (dsDNA) via the formation of T-Hg2+-T base pairs. Then, the dsDNA was removed from the surface of the PDNTs to restore the fluorescence...
May 11, 2018: Analyst
Quan Wang, Ruirui Zhang, Guoxing You, Jilin Hu, Penglong Li, Ying Wang, Jun Zhang, Yan Wu, Lian Zhao, Hong Zhou
Oxidative toxicity has impeded the development of haemoglobin-based oxygen carriers (HBOCs) by causing methaemoglobin (MetHb) formation and inducing oxidative stress. In our previous work, polydopamine-coated haemoglobin (Hb-PDA) nanoparticles have been designed and synthesized with the capacity to reduce oxidative toxicity. In this investigation, the mass ratio of dopamine (DA) to haemoglobin (Hb) and the pH value are found to be the primary factors that influence preparation of Hb-PDA nanoparticles. X-ray photoelectron spectroscopy showed that the catechol groups of DA play a crucial role in the modification of Hb surface...
May 10, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Seungkuk Ahn, Herdeline Ann M Ardoña, Johan U Lind, Feyisayo Eweje, Sean L Kim, Grant M Gonzalez, Qihan Liu, John F Zimmerman, Georgios Pyrgiotakis, Zhenyuan Zhang, Juan Beltran-Huarac, Paul Carpinone, Brij M Moudgil, Philip Demokritou, Kevin Kit Parker
Due to the unique physicochemical properties exhibited by materials with nanoscale dimensions, there is currently a continuous increase in the number of engineered nanomaterials (ENMs) used in consumer goods. However, several reports associate ENM exposure to negative health outcomes such as cardiovascular diseases. Therefore, understanding the pathological consequences of ENM exposure represents an important challenge, requiring model systems that can provide mechanistic insights across different levels of ENM-based toxicity...
May 10, 2018: Analytical and Bioanalytical Chemistry
Zhengao Wang, Jinquan Zeng, Guoxin Tan, Jingwen Liao, Lei Zhou, Junqi Chen, Peng Yu, Qiyou Wang, Chengyun Ning
To improve the osteointegration property of biomedical titanium, nano-architectured electroactive coating was synthesized through the electrochemical polymerization of dopamine and pyrrole. The highly binding affinity of Ca2+ to the catechol moiety of doped dopamine enabled efficient interaction between polypyrrole/polydopamine nanowires and mineral ions. The results indicate that the PPy/PDA nanowires preserved its efficient electro-activity and accelerated the hydroxyapatite deposition in a simulated body fluid...
March 2018: Bioactive Materials
A Sengottuvelan, P Balasubramanian, J Will, A R Boccaccini
Three dimensional TiO2 scaffolds are receiving renewed attention for bone tissue engineering (TE) due to their biocompatibility and attractive mechanical properties. However the bioactivity of these scaffolds is comparatively lower than that of bioactive glass or hydroxyapatite (HA) scaffolds. One strategy to improve bioactivity is to functionalize the surface of the scaffolds using biomolecules. Alkaline phosphatase (ALP) was chosen in this study due to its important role in the bone mineralization process...
June 2017: Bioactive Materials
Satar Tursynbolat, Yrysgul Bakytkarim, Jianzhi Huang, Lishi Wang
An ultrasensitive electrochemical sensor based on polydopamine/carboxylic multi-walled carbon nanotubes (MWCNTs-COOH) nanocomposites modified glassy carbon electrode (GCE) was presented in this work, which has been developed for highly selective and highly sensitive determination of an antimicrobial drug, metronidazole. The preparation of polydopamine/MWCNTs-COOH nanocomposites/GCE sensor is simple and possesses high reproducible, where polydopamine can be coated on the surface of MWCNTs-COOH via a simple electropolymerization process...
April 2018: Journal of Pharmaceutical Analysis
Huaihong Zhanga, Yu Sun, Rong Hung, Hui Cang, Zhaosheng Cai, Baiwang Sun
Combination of chemotherapy with photothermal therapy (PTT) demonstrate highly desirable for efficient medical treatment of tumor. At present works, camptothecin (CPT)-containing polymeric prodrug (PCPT) were fabricated by polymerization of a pH-sensitive camptothecin (CPT) prodrug monomer and MPC using reversible addition-fragmentation transfer (RAFT) strategy. The pH-sensitive polymeric prodrug was tethered onto surface of polydopamine (PDA) nanoparticles by amidation chemistry for combination of chemotherapy with photothermal therapy...
May 4, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Ognen Pop-Georgievski, Ralf Zimmermann, Ilya Kotelnikov, Vladimir Proks, Dirk Romeis, Jan Kucka, Anja Caspari, Frantisek Rypacek, Carsten Werner
Polymer layers capable of suppressing protein adsorption from biological media while presenting extracellular matrix derived peptide motifs offer valuable new options for biomimetic surface engineering. Herein, we provide detailed insights into physico-chemical changes induced in a non-fouling poly(ethylene oxide) (PEO) brush/polydopamine (PDA) system by incorporation of adhesion ligand (RGD) peptides. Brushes with high surface chain densities (σ ≥ 0.5 chains·nm-2 ) and pronounced hydrophilicity (water contact angles ≤ 10°) were prepared by end-tethering of hetero-bifunctional PEOs (Mn ~ 20000 g∙mol-1 ) to PDA-modified surfaces from a reactive melt...
May 4, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
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