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https://www.readbyqxmd.com/read/28525853/photoelectrochemical-sensitive-detection-of-insulin-based-on-cds-polydopamine-co-sensitized-wo3-nanorod-and-signal-amplification-of-carbon-nanotubes-polydopamine
#1
Rongyu Wang, Hongmin Ma, Yong Zhang, Qi Wang, Zhongping Yang, Bin Du, Dan Wu, Qin Wei
An ultrasensitive photoelectrochemical sandwich immunosensor was designed for detection of insulin based on WO3/CdS/polydopamine (WO3/CdS/PDA) co-sensitized and PDA@carbon nanotubes (PDA@CNT) conjugates for signal amplification. The CdS nanoparticles were first deposited on the WO3 nanorods via sequential chemical bath deposition to form the WO3/CdS structure to enhance photocurrent. Then equipped with PDA to form the WO3/CdS/PDA photosensitive structure. The PDA was used not only to reduce the toxicity of CdS but also adsorb insulin primary antibodies (Ab1)...
May 13, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28524663/polydopamine-generates-hydroxyl-free-radicals-under-uv-light-illumination
#2
Zehuan Wang, Feng Tang, Hailong Fan, Le Wang, Zhaoxia Jin
Polydopamine generally demonstrates as efficient free-radical scavenger. However, its free radical chemistry under illumination is unclear, which becomes important in view of growing studies of polydopamine applications in photoprotector and photothermal therapy. In this study, for the first time, we reported an experimental investigation of the generation of hydroxyl free-radicals from UV-illuminated polydopamine in aqueous environment. By using terephthalic acid as fluorescent probe, we have measured hydroxyl radicals generated from UV-illuminated polydopamine with different shapes and sizes...
May 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28513711/a-novel-approach-for-fabricating-highly-tunable-and-fluffy-bioinspired-3d-poly-vinyl-alcohol-pva-fiber-scaffolds
#3
Sunanda Roy, Shreyas Kuddannaya, Tanya Das, Heng Yeong Lee, Jacob Lim, Xiao 'Matthew' Hu, Yue Chee Yoon, Jaehwan Kim
The excellent biocompatibility, biodegradability and chemo-thermal stability of poly(vinyl alcohol) (PVA) have been harnessed in diverse practical applications. These properties have motivated the fabrication of high performance PVA based nanofibers with adequate control over the micro and nano-architectures and surface chemical interactions. However, the high water solubility and hydrophilicity of the PVA polymer limits the application of the electrospun PVA nanofibers in aqueous environments owing to instantaneous dissolution...
May 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28509913/optimization-of-a-polydopamine-pd-based-coating-method-and-polydimethylsiloxane-pdms-substrates-for-improved-mouse-embryonic-stem-cell-esc-pluripotency-maintenance-and-cardiac-differentiation
#4
Jiayin Fu, Yon Jin Chuah, Wee Tong Ang, Nan Zheng, Dong-An Wang
Myocardiocyte derived from pluripotent stem cells, such as induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), is a promising cell source for cardiac tissue engineering. Combined with microfluidic technologies, a heart-on-a-chip is very likely to be developed and function as a platform for high throughput drug screening. Polydimethylsiloxane (PDMS) silicone elastomer is a widely-used biomaterial for the investigation of cell-substrate interactions and biochip fabrication. However, the intrinsic PDMS surface hydrophobicity inhibits cell adhesion on the PDMS surface, and PDMS surface modification is required for effective cell adhesion...
May 16, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28508635/polydopamine-coated-manganese-carbonate-nanoparticles-for-amplified-magnetic-resonance-imaging-guided-photothermal-therapy
#5
Youxing Cheng, Shupeng Zhang, Ning Kang, Jianpan Huang, Xiaolin Lv, Kai Wen, Shefang Ye, Zhiwei Chen, Xi Zhou, Lei Ren
This study reports a multifunctional nanoparticle (NP) with function of amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) by the surface coating of polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA, it helps entrap large quantities of water around NPs and allow more efficient water exchange, leading to greatly improved MR contrast signals compared with the one without PDA coating. Besides, the distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region...
May 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28505563/ultrasensitive-magnetic-field-assisted-surface-plasmon-resonance-immunoassay-for-human-cardiac-troponin-i
#6
Qiong Wu, Ying Sun, Di Zhang, Shuo Li, Yue Zhang, Pinyi Ma, Yang Yu, Xinghua Wang, Daqian Song
An ultrasensitive surface plasmon resonance (SPR) immunoassay was developed for the specific detection of human cardiac troponin I (cTnI), a principle diagnostic marker for myocardial damage. The thin gold film evaporated on a glass slate, which was employed as the SPR sensing film, was modified by hollow gold nanoparticles (HGNPs) and polydopamine (PDA) sequentially, and then was immobilized with antibodies for specific recognition of target analyte. Electronic coupling of the surface plasmon waves originating from the HGNPs and the gold film leads to the remarkable amplification of SPR response...
May 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28501171/a-novel-magnetic-photoluminescence-bifunctional-nanohybrid-for-the-determination-of-trypsin
#7
Tingting Xia, Qiang Ma, Tianyu Hu, Xingguang Su
In this work, we have designed a novel kind of nanohybrid with magnetic and photoluminescence (PL) property for trypsin detection. The modified magnetic Fe3O4 nanoparticles (MNPs) with polydopamine (PDA) and human serum albumin (HSA) were prepared through a one step self-polymerization under mild condition. The polydopamine (PDA) coating on MNPs can improve the biocompatibility of the MNP-PDA-HAS composite due to its hydrophilicity and multifunctional groups. When MNP-PDA-HSA composite was added into the Anti-HSA modified CdTe QDs (anti-HSA-QDs), HSA on the MNP-PDA-HSA composite was captured by the site of anti-HSA-QDs to form MNP-PDA-HSA/anti-HSA-QDs nanohybrid...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28501170/a-star-shaped-poly-2-methyl-2-oxazoline-based-antifouling-coating-application-in-investigation-of-the-interaction-between-acetaminophen-and-bovine-serum-albumin-by-frontal-analysis-capillary-electrophoresis
#8
Haiqin Du, Chong Zhang, Ke Mao, Yanmei Wang
In this work, an antifouling capillary modified with star-shaped poly(2-methyl-2-oxazoline)-based copolymer was used to study the interaction between acetaminophen (APAP) and bovine serum albumin (BSA) by frontal analysis capillary electrophoresis (FACE). The star-shaped copolymer, poly(ethylene imine)-graft-poly(2-methyl-2-oxazoline) (PEI-g-PMOXA), was immobilized onto the fused-silica capillary inner wall via dopamine-assisted co-deposition strategy, yielding a PEI-g-PMOXA/polydopamine (PDA)-coated antifouling capillary, i...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28501155/morphology-tunable-polydopamine-nanoparticles-and-their-application-in-fe-3-detection
#9
Peng Qi, Dun Zhang, Yi Wan
In this work, we discovered the morphology transformation property of polydopamine (PDA) nanomaterials, the addition of Fe(3+) initiated the dramatic morphology transformation of PDA dots from aggregated plate-like to uniform willow-leaf-like morphology. Further study revealed that this fascinating morphology transformation process could be attributed to the oxidative nature and coordination characteristic of Fe(3+). This is the first report on the morphology transformation ability of PDA, and a probable self-assembled mechanism was proposed to explain this issue...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28499200/interactions-of-mussel-inspired-polymeric-nanoparticles-with-gastric-mucin-implications-for-gastro-retentive-drug-delivery
#10
Suhair Sunoqrot, Lina Hasan, Aya Alsadi, Rania Hamed, Ola Tarawneh
Mussel-inspired polydopamine (pD) coatings have several unique characteristics such as durability, versatility, and robustness. In this study, we have designed pD-coated nanoparticles (NPs) of methoxy polyethylene glycol-b-poly(ε-caprolactone) (mPEG-PCL@pD) as prospective nanoscale mucoadhesive platforms for gastro-retentive drug delivery. Successful pD coating on the NPs was confirmed by Transmission Electron Microscopy and X-ray Photoelectron Spectroscopy. Mucoadhesion of pD-coated NPs was investigated in vitro using commercially available mucin under stomach lumen-mimetic conditions...
May 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28498064/polydopamine-polyethyleneimine-complex-adhered-to-micrometer-sized-magnetic-carbon-fibers-for-high-efficiency-hemoperfusion
#11
Rui-Lin Liu, Yan Wang, Xian-Li Ge, Pei Yu, Hui-Qin Liu, Ming-Chan Wang, Wen Lu, Qiang Fu
Carbon-based nanomaterials have recently attracted tremendous attention in adsorption, separation and biological fields. However, such modification is not always straightforward when the surface is not chemically reactive. Given this reason, most carbon materials modification processes employ reactive linkers or coupling agents, which are complicated and time-consuming. Herein, we report on a dopamine-polyethyleneimine (PEI) coating strategy to fabricate micrometer-sized magnetic carbon fiber (MSMCF)-based extracorporeal blood-cleansing sorbent for hemoperfusion...
May 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28497772/surface-rough-fe-n-c-composite-wrapped-on-carbon-nanotubes-as-efficient-electrocatalyst-for-oxygen-reduction-reaction
#12
Chunhui Xiao, Xu Chen, Yuhai Tang
Fe-N/C composites are considered one of the most promising non-precious-metal electrocatalysts for oxygen reduction reaction (ORR). In this paper, we fabricate a novel and efficient carbon nanotube (CNT)-supported Fe-N/C composite catalyst, via the surface-self-polymerization of polydopamine and then the incorporation with Fe species on CNTs, followed by the pyrolysis process. The obtained catalyst demonstrates excellent electrocatalytic performance towards ORR in alkaline media. The modification of Fe-incorporated nitrogen-rich-carbons (Fe-CNx) on CNTs lowers the ORR half-wave-potential by ∼190 mV, giving this catalyst with an onset ORR potential of 0...
June 2, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28497681/a-ph-sensitive-delivery-vehicle-based-on-folic-acid-conjugated-polydopamine-modified-mesoporous-silica-nanoparticles-for-targeted-cancer-therapy
#13
Wei Cheng, Junpeng Nie, Lv Xu, Chaoyu Liang, Yunmei Peng, Gan Liu, Teng Wang, Lin Mei, Laiqiang Huang, Xiaowei Zeng
In this study, we introduced a targeting polymer poly (ethylene glycol)-folic acid (PEG-FA) on the surface of a polydopamine (PDA)-modified mesoporous silica nanoparticles (MSNs) to develop a novel nanoparticle (NP) MSNs@PDA-PEG-FA, which was employed as a drug delivery system loaded with doxorubicin (DOX) as a model drug for cervical cancer therapy. The chemical structure and properties of this NP were characterized by the transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), N2 adsorption/desorption, dynamic light scattering-autosizer (DLS), thermogravimetric analysis (TGA) and FT-IR spectrophotometer...
May 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28493469/nature-inspired-synthesis-of-nanostructured-electrocatalysts-through-mineralization-of-calcium-carbonate
#14
Jong Wan Ko, Eun Jin Son, Chan Beum Park
Biomineralization is a biogenic process that produces elaborate inorganic and organic hybrid materials in nature. Inspired by the natural process, this study explores novel mineralization approach to create nanostructured CaCO3 films composed of amorphous CaCO3 hemispheres using catechol-rich polydopamine (PDA) as a biomimetic mediator. We successfully transformed thus-synthesized biomimetic CaCO3 to nanostructured films of metal oxide minerals, such as FeOOH, CoCO3, NiCO3, and MnOOH, via a simple procedure...
May 10, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28488853/metal-organic-framework-template-synthesis-of-nico2s4-c-encapsulated-in-hollow-nitrogen-doped-carbon-cubes-with-enhanced-electrochemical-performance-for-lithium-storage
#15
Dongxia Yuan, Gang Huang, Dongming Yin, Xuxu Wang, Chunli Wang, Limin Wang
Owing to its richer redox reaction and remarkable electrical conductivity, bimetallic nickel cobalt sulfide (NiCo2S4) is considered as an advanced electrode material for energy-storage applications. Herein, nanosized NiCo2S4@C encapsulated in a hollow nitrogen-doped carbon cube (NiCo2S4@D-NC) has been fabricated using a core@shell Ni3[Co(CN)6]2@polydopamine (PDA) nanocube as the precursor. In this composite, the NiCo2S4 nanoparticles coated with conformal carbon layers are homogeneously embedded in a 3D high-conduction carbon shell from PDA...
May 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28485431/skin-safe-photothermal-therapy-enabled-by-responsive-release-of-acid-activated-membrane-disruptive-polymer-from-polydopamine-nanoparticle-upon-very-low-laser-irradiation
#16
Rui Zhu, Feng Gao, Ji-Gang Piao, Lihua Yang
How to ablate tumor without damaging skin is a challenge for photothermal therapy. We, herein, report skin-safe photothermal cancer therapy provided by the responsive release of acid-activated hemolytic polymer (aHLP) from the photothermal polydopamine (PDA) nanoparticle upon irradiation at very low dosage. Upon skin-permissible irradiation (via an 850 nm laser irradiation at the power density of 0.4 W cm(-2)), the nanoparticle aHLP-PDA generates sufficient localized-heat to bring about mild hyperthermia treatment and consequently, responsively sheds off the aHLP polymer from its PDA nanocore; this leads to selective cytotoxicity to cancer cells under the acidic conditions of the extracellular microenvironment of tumor...
May 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28482467/novel-mussel-inspired-ti-6al-4v-surfaces-with-biocompatibility-blood-ultra-drag-reduction-and-superior-durability
#17
Qi Li, Fei Tang, Chunze Wang, Xiaohao Wang
In order to develop new Ti-based biomaterials with biocompatibility, blood ultra-drag reduction and superior durability, a novel fabrication combining simple electrochemical and chemical processes was proposed. After being modified by C14H19F13O3Si (FAS), a biocompatible TiO2-SiO2-polydopamine composite surface on Ti-6Al-4V substrate was obtained. The biocompatibility was evaluated using a series of in vitro test, revealing that compared with Ti-6Al-4V alloys, the surfaces exhibited a number of bio-advantages such as anti-platelet aggregation, anti-bovine serum albumin protein adsorption, a lower hemolysis rate (~0...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481511/ph-responsive-nir-absorbing-fluorescent-polydopamine-with-hyaluronic-acid-for-dual-targeting-and-synergistic-effects-of-photothermal-and-chemotherapy
#18
Sung Han Kim, Insik In, Sung Young Park
In cancer therapy, optimizing tumor-specific delivery, tumor distribution, and cellular uptake of a drug is important for ensuring minimal toxicity and maximum therapeutic efficacy. This study characterized the therapeutic efficacy of a stimulus responsive and dual targeting nanocarrier for a bioimaging-guided photothermal and chemotherapeutic platform. Hyaluronic acid (HA) conjugated with triphenylphosphonium (TPP) and boronic acid (BA) diol-linked β-cyclodextrin (β-CD) forms an inclusion complex with paclitaxel (PTX), creating a shell-like composite on a core of carbonized fluorescent polydopamine nanoparticles (FNPs-pDA) applicable for photothermal therapy as well as bioimaging...
May 12, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28481505/mitochondria-targeting-polydopamine-nanoparticles-to-deliver-doxorubicin-for-overcoming-drug-resistance
#19
Wen-Qing Li, Zhigang Wang, Sijie Hao, Hongzhang He, Yuan Wan, Chuandong Zhu, Li-Ping Sun, Gong Cheng, Si-Yang Zheng
Mitochondria play a critical role in diverse cellular processes, such as energy production and apoptosis regulation. The mitochondria-targeted drug delivery is becoming a potential novel strategy for overcoming drug resistance in cancer therapy. Herein, we synthesize nature-inspired dopamine-derived polydopamine (PDA) nanoparticles. Using triphenylphosphonium (TPP) as the mitochondrial penetration molecule to improve the target efficiency, we synthesize poly(ethylene glycol) (PEG)-modified PDA (PDA-PEG) and TPP-functionalized PEG-modified PDA (PDA-PEG-TPP) nanoparticles...
May 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28479854/mn-2-coordinated-pda-dox-plga-nanoparticles-as-a-smart-theranostic-agent-for-synergistic-chemo-photothermal-tumor-therapy
#20
Juqun Xi, Lanyue Da, Changshui Yang, Rui Chen, Lizeng Gao, Lei Fan, Jie Han
Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn(2+)-coordinated doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles...
2017: International Journal of Nanomedicine
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