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Zhuoyue Chen, Zhen Zhang, Juantao Feng, Yayuan Guo, Yuan Yu, Jihong Cui, Hongmin Li, Lijun Shang
One of the key challenges in bone healing and regeneration is the implant with osteoinductive activity. Therapeutic application of recombinant human bone morphogenetic protein-2 (rhBMP-2) is a promising approach to enhance osteogenesis. However, high dose and uncontrolled burst in the release kinetics of BMP-2 may introduce oedema, bone overgrowth, cyst-like bone formation and significant inflammation. In this study, low dose BMP-2 of 1µg was used to design PLA-PD-BMP for functionalization of polylactic acid (PLA) implants via mussel-inspired polydopamine (PD) assist...
March 21, 2018: ACS Applied Materials & Interfaces
Dongsheng Zhang, Weixiang Li, Zhanfang Ma
An improved sandwich-type electrochemical immunosensor based on the novel signal amplification strategy was developed. Methylene blue (MB) loaded mesoporous silica nanoparticles (MSN) with polydopamine coating (PDA) were employed as "smart" labels, while phytic acid doped polyaniline hydrogel (PANI) with high adsorption capacity was acted as substrate. In this strategy, amount of redox species (MB) encapsulated in MSN by PDA will be released under acidic condition and then absorbed stably by PANI...
March 13, 2018: Biosensors & Bioelectronics
Menglong Liu, Danfeng He, Tao Yang, Wei Liu, Li Mao, Yang Zhu, Jun Wu, Gaoxing Luo, Jun Deng
BACKGROUND: Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in vivo therapeutic application. Integration of two distinctive bactericides into one entity is a promising platform to improve the efficiency of antimicrobial agents. RESULTS: In this study, a chemo-photothermal therapeutic platform based on polydopamine (PDA)-coated gold nanorods (GNRs) was developed...
March 16, 2018: Journal of Nanobiotechnology
Radosław Mrówczyński, Artur Jędrzak, Kosma Szutkowski, Bartosz F Grześkowiak, Emerson Coy, Roksana Markiewicz, Teofil Jesionowski, Stefan Jurga
Polydopamine (PDA)-coated magnetic nanoparticles functionalized with mono-6-thio-β-cyclodextrin (SH-βCD) were obtained and characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Nuclear and Magnetic Resonance Imaging (NMR and MRI), and doxorubicin (DOXO)-loading experiments. The liver cancer cellular internalization of DOXO-loaded nanoparticles was investigated by confocal imaging microscopy. Synthesized nanomaterials bearing a chemotherapeutic drug and a layer of polydopamine capable of absorbing near-infrared light show high performance in the combined chemo- and photothermal therapy (CT-PTT) of liver cancer due to the synergistic effect of both modalities as demonstrated in vitro...
March 16, 2018: Nanomaterials
Jianfeng Zhang, Qunling Fang, Jinyu Duan, Hongmei Xu, Hua-Jian Xu, Shouhu Xuan
This work reports a novel Fe3O4@polydopamine-Au-polydopamine core/shell nanocomposite towards magnetically separable nanocatalyst. Because the polydopamine (PDA) layers sandwiched Au nanocrystals were prepared by a layer-by-layer method, the content of Au could be controlled by varying the Au shell number (such as burger-like Fe3O4@PDA/Au/PDA/Au/PDA). The Fe3O4@PDA/Au/PDA exhibited excellent catalytic activity on reducing the p-Nitrophenol since the substrate could penetrate the PDA shell. Owing to the protection of PDA shell, the Fe3O4@PDA/Au/PDA presented higher cyclability than the Fe3O4@PDA/Au...
March 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Shoushuang Huang, Haitao Wang, Shangdai Wang, Zhangjun Hu, Ling Zhou, Zhiwen Chen, Yong Jiang, Xuefeng Qian
Designing low-cost electrocatalysts combining the features of outstanding catalytic activity, excellent electrical conductivity, and high chemical stability remains a critical challenge for the large-scale fabrication of dye-sensitized solar cells (DSSCs). Here we report the controlled synthesis of CoS2 -CoSe2 heterostructured nanocrystals encapsulated in N-doped carbon hollow nanocubes (CoS2 -CoSe2 @NC) through simultaneous sulfurization and selenization of polydopamine coated Prussian blue analogs. Benefiting from both structural and compositional characteristics, namely, the synergistic effect of CoS2 -CoSe2 heterojunctions, the conductive N-doped carbon coating and the porous structure of the nanocubes, the resultant CoS2 -CoSe2 @NC nanocubes exhibit excellent electrocatalytic activity and cycling stability toward the generation of I3 - ions in DSSCs...
March 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Jutaek Nam, Sejin Son, Lukasz J Ochyl, Rui Kuai, Anna Schwendeman, James J Moon
Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus precluding its utility against disseminated, metastatic tumors. Here, we demonstrate that PTT combined with chemotherapy can trigger potent anti-tumor immunity against disseminated tumors. Specifically, we have developed polydopamine-coated spiky gold nanoparticles as a new photothermal agent with extensive photothermal stability and efficiency. Strikingly, a single round of PTT combined with a sub-therapeutic dose of doxorubicin can elicit robust anti-tumor immune responses and eliminate local as well as untreated, distant tumors in >85% of animals bearing CT26 colon carcinoma...
March 14, 2018: Nature Communications
Zihan An, Fengying Dai, Chenjie Wei, Yiping Zhao, Li Chen
Membrane surface design is significant for the development and application of synthetic polymer hemodialysis membranes. In this study, the influence of zwitterionic cysteine on poly(vinylidene fluoride) (PVDF) hollow fiber membrane was investigated. The polydopamine layer was formed through dopamine self-polymerization on PVDF membrane surface, and then cysteine was covalent grafted onto the layer to improve the anti-biofouling property and hemocompatibility. The elementary composition of membrane surfaces was characterized by X-ray photoelectron spectroscopy...
March 14, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Gyo Eun Gu, Chul Soon Park, Hyun-Ju Cho, Tai Hwan Ha, Joonwon Bae, Oh Seok Kwon, Jeong-Soo Lee, Chang-Soo Lee
Fluorescent polydopamine nanoparticles (FPNPs) are prepared via the ethylenediamine (EDA)-induced degradation of as-prepared non-fluorescent polydopamine (PDA) and used for targeted bioimaging. The reductive treatment of PDA in the presence of EDA yields fluorescent precipitates, inspiring us to seek various biological approaches to preparing FPNPs with excellent optical and biocompatible properties. Moreover, we firstly found that FPNPs selectively label neuromast hair cells in the lateral line of zebrafish, their applications as a reliable fluorescent indicator to investigate the neuromast hair cells, to in turn determine the viability of hair cells, was demonstrated...
March 13, 2018: Scientific Reports
Yi-Ran Wang, Guang-Xia Chen, Shi-Yan Yang, Ping Wei
Gastric cancer is the third leading cause of cancer-associated death worldwide. Although a decrease in its incidence is observed, gastric cancer still poses a major clinical challenge due to poor prognosis and limited treatments. Barbaloin (BBL) is a main medicinal composition of the Chinese traditional medicine aloe vera. BBL has various bioactivities, including anti-oxidant, anti-inflammatory and anti-tumor properties. Polydopamine (pD)-based surface modification is easy to functionalize polymeric nanoparticles (NPs) surfaces with ligands and/or additional polymeric layers...
March 10, 2018: Biochemical and Biophysical Research Communications
Marwa M Azab, Rédha Cherif, Aryanne L Finnie, Maha M Abou El-Alamin, Maha A Sultan, Alastair W Wark
Gold nanorods (NRs) have attracted a great deal of interest for a variety of biomedical and sensing applications. However, developing robust methods for biofunctionalizing NRs has continued to be challenging, especially for NR-DNA conjugates. This is due to the presence of cetyltrimethylammonium bromide (CTAB), which plays an essential role in controlling the anisotropic particle growth. In this article, we systematically explore the growth of a polydopamine (PDA) layer on a range of NR surfaces, comparing different polyelectrolyte and alkanethiol coatings as well as direct CTAB displacement...
March 13, 2018: Analyst
Fei-Fei Chen, Ying-Jie Zhu, Feng Chen, Li-Ying Dong, Ri-Long Yang, Zhi-Chao Xiong
Wallpaper with multiple functions, such as fire resistance and an automatic alarm in fire disasters, will be attractive for the interior decoration of houses. Herein, we report a smart fire alarm wallpaper prepared using fire-resistant inorganic paper based on ultralong hydroxyapatite nanowires (HNs) and graphene oxide (GO) thermosensitive sensors. At room temperature, the GO thermosensitive sensor is in a state of electrical insulation; however, it becomes electrically conductive at high temperatures. In a fire disaster, high temperature will rapidly remove the oxygen-containing groups of GO, leading to the transformation process of GO from an electrically insulated state into an electrically conductive one...
March 13, 2018: ACS Nano
Yun Zeng, Wenyan Liu, Zheyu Wang, Srikanth Singamaneni, Risheng Wang
Surface functionalization of nanodiamonds (NDs), which is of great interest in advanced material and therapeutic applications, requires the immobilization of functional species, such as nucleic acids, bioprobes, drugs, and metal nanoparticles onto NDs' surfaces to form stable nanoconjugates. However, it is still challenging to modify the surface of NDs due to the complexity of their surface chemistry and the low density of each functional group on the surfaces of NDs. In this work, we demonstrate a general applicable surface functionalization approach for the preparation of ND-based core-shell nanoconjugates using dopamine polymerization...
March 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Błażej Scheibe, Radosław Mrówczyński, Natalia Michalak, Karol Załęski, Michał Matczak, Mateusz Kempiński, Zuzanna Pietralik, Mikołaj Lewandowski, Stefan Jurga, Feliks Stobiecki
Reduced graphene oxide-magnetite hybrid aerogels attract great interest thanks to their potential applications, e.g., as magnetic actuators. However, the tendency of magnetite particles to migrate within the matrix and, ultimately, escape from the aerogel structure, remains a technological challenge. In this article we show that coating magnetite particles with polydopamine anchors them on graphene oxide defects, immobilizing the particles in the matrix and, at the same time, improving the aerogel structure...
2018: Beilstein Journal of Nanotechnology
Na Kong, Mei Deng, Xiu-Na Sun, Yi-Ding Chen, Xin-Bing Sui
Current limitations of cancer therapy include the lack of effective strategy for target delivery of chemotherapeutic drugs, and the difficulty of achieving significant efficacy by single treatment. Herein, we reported a synergistic chemo-photothermal strategy based on aptamer (Apt)-polydopamine (pD) functionalized CA-(PCL- ran -PLA) nanoparticles (NPs) for effective delivery of docetaxel (DTX) and enhanced therapeutic effect. The developed DTX-loaded Apt-pD-CA-(PCL- ran -PLA) NPs achieved promising advantages, such as (i) improved drug loading content (LC) and encapsulation efficiency (EE) initiated by star-shaped copolymer CA-(PCL- ran -PLA); (ii) effective target delivery of drugs to tumor sites by incorporating AS1411 aptamers; (iii) significant therapeutic efficacy caused by synergistic chemo-photothermal treatment...
2018: Frontiers in Pharmacology
Yingying Liu, Yulong Sui, Chao Liu, Changqing Liu, Meiyan Wu, Bin Li, Youming Li
In this study, we reported a pH/near-infrared (NIR)-responsive hydrogel for on-demand drug delivery and wound healing. Cellulose nanofibrils (TOCNFs) were produced by 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated oxidation method. Polydopamine (PDA) was introduced into TOCNFs network to fabricate a PDA/TOCNFs hydrogel through ion-crosslinking with calcium ion as a crosslinker. Then, tetracycline hydrochloride (TH) which loaded on PDA could be released from the prepared hydrogels in an on-demand fashion under NIR exposure or at lower pH conditions...
May 15, 2018: Carbohydrate Polymers
Dae Gon Lim, Racelly Ena Prim, Eunah Kang, Seong Hoon Jeong
The self-organizing complexes with hyaluronic acid (HA) and polydopamine (PDA), an adhesion mediator via hydrogen bonding, were investigated for use as protein drug carriers. The complexes were prepared with HA of different molecular weights (20 kDa and 200 kDa) and various molar ratios of dopamine and lysozyme, a model protein. Dopamine-conjugated HA (HADA)/PDA complexes were prepared by one-pot synthesis by relying on the self-polymerization of dopamine under oxidative, weakly basic conditions. Lysozyme was bound via coacervation and hydrogen bonding into HADA/PDA complexes...
March 7, 2018: International Journal of Pharmaceutics
Sajeesh Kumar Madhurakkat Perikamana, Jinkyu Lee, Taufiq Ahmad, Eun Mi Kim, Hayeon Byun, Sangmin Lee, Heungsoo Shin
Tendon-bone interface tissue is extremely challenging to engineer because it exhibits complex gradients of structure, composition, biologics, and cellular phenotypes. As a step toward engineering these transitional zones, we initially analyzed how different (topographical or biological) cues affect tenogenic differentiation of adipose-derived stem cells (ADSCs). We immobilized platelet-derived growth factor - BB (PDGF-BB) using polydopamine (PD) chemistry on random and aligned nanofibers and investigated ADSC proliferation and tenogenic differentiation...
February 27, 2018: Biomaterials
Pan Cao, Ying Yang, Fidelia Ijeoma Uche, Sarah Ruth Hart, Wen-Wu Li, Chengqing Yuan
Modification of metal surfaces with antimicrobial peptides is a promising approach to reduce bacterial adhesion. Here, cyclic peptides or cycloids, possessing remarkable stability and antimicrobial activities, were extracted and purified from Viola philippica Cav., and identified using mass spectrometry. Cyclotides were subsequently utilized to modify stainless steel surfaces via polydopamine-mediated coupling. The resulting cyclotide-modified surfaces were characterized by Fourier transform infrared (FTIR) spectroscopy and contact angle analysis...
March 9, 2018: International Journal of Molecular Sciences
Xiaoli Wu, Yifan Li, Xulin Cui, Jingtao Wang, Xingzhong Cao, Peng Zhang, Lingyun Zheng
Thin-film composite (TFC) membranes show exceptional permeation properties of key importance for many separations. However, their design and development need ultrathin and defect-free nanofilm as active layer to alleviate the bottleneck of permeation-rejection trade-off. Here a 25 nm-thick film is fabricated on porous support by introducing polydopamine (PDA) as an adsorption layer, imparting a unique adsorption-assisted interfacial polymerization (IP) strategy. PDA layer efficiently captures and enriches amine monomers even from ultra-dilute solution towards uniform stacking on the support, thus generating ultrathin and defect-free film after polymerization...
March 8, 2018: ACS Applied Materials & Interfaces
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