Yuhan Zheng, Qingyun Wei, Xuan Han, Xiangmin Tao, Tao Cao, Tianbao Chen, Peng Cao, Qichen Zhan
Despite exhibiting potent anticancer activity, the strong hemolytic properties of melittin (MEL) significantly restrict its delivery efficiency and clinical applications. To address this issue, we have devised a strategy wherein homologous dopamine (DA), an essential component of bee venom, is harnessed as a vehicle for the synthesis of MEL-polydopamine (PDA) nanoparticles (MP NPs). The ingenious approach lies in the fact that MEL is a basic polypeptide, and the polymerization of DA is also conducted under alkaline conditions, indicating the distinctive advantages of PDA in MEL encapsulation...
May 10, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine