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https://www.readbyqxmd.com/read/28945061/a-comparative-study-of-cfd-of-canine-model-of-common-carotid-fusiform-aneurysm-and-vertebrobasilar-fusiform-aneurysm-in-human-patients
#1
Shewei Guo, Peng Jiang, Jian Liu, Xinjian Yang, Chuhan Jiang, Youxiang Li, Zhongxue Wu
BACKGROUND: Intracranial fusiform aneurysm (IFA) is a relatively uncommon subgroup of aneurysms. There are few reports that focus on the hemodynamics of IFA. In this study, we compared the hemodynamics of the canine model of common carotid fusiform aneurysm and vertebrobasilar fusiform aneurysms in human patients. METHODS: Five male mongrel dogs were randomly chosen, and there unilateral common carotid artery (CCA) and external jugular vein were surgically exposed individually...
September 22, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28944594/effect-of-clonidine-on-the-efficacy-of-lignocaine-local-anesthesia-in-dentistry-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Gowri Sivaramakrishnan, Kannan Sridharan
Alternatives to adrenaline with lignocaine local anesthesia, such as clonidine, have been trialed in various randomized, controlled trials. Therefore, the aim of the present systematic review was to compile the available evidence on using clonidine with lignocaine for dental anesthesia. Electronic databases were searched for eligible studies. A data-extraction form was created, extracted data were analyzed using non-Cochrane mode in RevMan 5.3 software. Heterogeneity between the studies were assessed using the forest plot, I(2) statistics (where >50% was considered to have moderate-to-severe heterogeneity), and χ(2) -test...
September 24, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28944581/a-new-one-step-procedure-for-pulmonary-valve-implantation-of-the-melody-valve-simultaneous-prestenting-and-valve-implantation
#3
Younes Boudjemline
OBJECTIVES: To describe a new modification, the one-step procedure, that allows interventionists to pre-stent and implant a Melody valve simultaneously. BACKGROUND: Percutaneous pulmonary valve implantation (PPVI) is the standard of care for managing patients with dysfunctional right ventricular outflow tract, and the approach is standardized. METHODS: Patients undergoing PPVI using the one-step procedure were identified in our database. Procedural data and radiation exposure were compared to those in a matched group of patients who underwent PPVI using the conventional two-step procedure...
September 25, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28944481/efficacy-of-dexmedetomidine-on-perioperative-morbidity-during-nasal-surgery-a-meta-analysis
#4
Se Hwan Hwang, Ho Seok Lee, Young Hoon Joo, Jae Hyun Seo, Jun Myung Kang
OBJECTIVES: The goal of this meta-analysis was to perform a systematic review of the literature on the effect of dexmedetomidine on perioperative morbidity following nasal surgery and on the adverse effects of dexmedetomidine. DATA SOURCES: MEDLINE, Scopus, and Cochrane Database of Systematic Reviews. REVIEW METHODS: Two authors independently searched scientific and medical databases from their inception of article collection to March 2017...
September 25, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28944180/surgical-management-of-atrial-fibrillation-at-the-time-of-septal-myectomy
#5
Eduard Quintana, James L Cox
Atrial fibrillation (AF) may appear during the natural clinical course of hypertrophic cardiomyopathy (HCM). It is regarded as a complication of HCM and is a marker of advanced disease. AF is more likely to occur in untreated, obstructive HCM. Unfortunately, this represents a turning point that puts patients at increased risk of further disability, stroke and death. The presence of obstruction is an indication to proceed with septal myectomy to improve or resolve symptoms by ameliorating diastolic dysfunction...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944175/long-term-outcome-of-simultaneous-septal-myectomy-and-anterior-mitral-leaflet-retention-plasty-in-hypertrophic-obstructive-cardiomyopathy-the-berlin-experience
#6
Eva Maria Delmo Walter, Mariano Francisco Javier, Roland Hetzer
BACKGROUND: Various surgical strategies designed to relieve left ventricular outflow tract obstruction (LVOTO) and correct mitral regurgitation (MR) in hypertrophic obstructive cardiomyopathy (HOCM) have evolved, yet reports on the long-term outcomes of each technique are scarce. We provide an update on over 20 years' experience at our institution in the standardized surgical treatment of HOCM. METHODS: Between April 1986 and April 2014, 320 cases of endomyocardial resection and 305 septal myectomies were performed at our institution...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944122/a-case-of-large-hemodynamically-significant-abdominal-wall-hematoma-following-paracentesis-in-a-cirrhotic-patient
#7
Samina Afreen, Usha Deonarine, Funmilola Ogundipe, Alicia Thomas
Paracentesis is a safe procedure with severe bleeding occurring in less than 1% of cases. Paracentesis is often times performed as an outpatient procedure. Hemorrhagic complications can be rapidly fatal if not diagnosed and treated in a timely fashion. We present the case of a 55-year-old female with decompensated cirrhosis who developed hemodynamically significant bleeding post paracentesis. This case brings up the question whether certain patients who undergo paracentesis should be admitted for close observation for at least 24 hours after the procedure...
July 17, 2017: Curēus
https://www.readbyqxmd.com/read/28943527/crossing-bridges-between-extra-and-intra-cellular-events-in-thoracic-aortic-aneurysms
#8
Yoshito Yamashiro, Hiromi Yanagisawa
Thoracic aortic aneurysms (TAAs) are common, life-threatening diseases and are a major cause of mortality and morbidity. Over the past decade, genetic approaches have revealed that 1) activation of the transforming growth factor beta (TGF-β) signaling, 2) alterations in the contractile apparatus of vascular smooth muscle cells (SMCs), and 3) defects in the extracellular matrix (ECM) were responsible for development of TAAs. Most recently, a fourth mechanism has been proposed in that dysfunction of mechanosensing in the aortic wall in response to hemodynamic stress may be a key driver of TAAs...
September 22, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28942616/differences-in-right-ventricular-morphology-not-function-indicate-the-nature-of-increased-afterload-in-pulmonary-hypertensive-subjects-with-normal-left-ventricular-function
#9
Farhan Raza, Catherine Dillane, Arslan Mirza, Yevgeniy Brailovsky, Sheila Weaver, Martin G Keane, Paul Forfia
BACKGROUND: The aim of study was to assess whether a specific morphology of the right ventricle (RV) by 2D echo predicts the hemodynamic nature of pulmonary hypertension (PH). METHODS: We reviewed clinical, 2D echo, and hemodynamic data of 100 patients with PH: divided into three groups: PH from pulmonary vascular disease (PHPVD ; n = 34) with pulmonary vascular resistance (PVR) > 3 mm Hg/L/min (Wood unit [WU]) and pulmonary artery wedge pressure (PAWP) ≤ 15 mm Hg, pulmonary venous hypertension (PVH; n = 33) with PVR < 3 WU and PAWP > 15 mm Hg and PHMIXED (n = 33) with PVR > 3 WU and PAWP > 15 mm Hg...
September 24, 2017: Echocardiography
https://www.readbyqxmd.com/read/28942508/role-of-inducible-nitric-oxide-synthase-in-myocardial-ischemia-reperfusion-injury-in-sleep-deprived-rats
#10
Sajad Jeddi, Asghar Ghasemi, Alireza Asgari, Amir Nezami-Asl
INTRODUCTION: REM sleep deprivation (SD) decreases tolerance of the rat heart to ischemia-reperfusion (IR) injury; the underlying mechanisms, however, are unknown. This study aimed at determining whether changes in iNOS, Bax, and Bcl-2 gene expression are involved in this detrimental effect. METHOD: SD was induced by flowerpot technique for a period of 4 days. This method is simple and able to induce sleep fragmentation which occurs as one of the sleep disorder symptoms in clinical conditions...
September 23, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28942082/elucidation-of-protective-efficacy-of-pentahydroxy-flavone-isolated-from-madhuca-indica-against-arsenite-induced-cardiomyopathy-role-of-nrf-2-ppar-%C3%AE-c-fos-and-c-jun
#11
Anwesha A Mukherjee, Amit D Kandhare, Subhash L Bodhankar
BACKGROUND: Madhuca indica J. F. Gmel. (Sapotaceae) is widely used ethnobotanically as anti-diabetic, antipyretic, hepatoprotective, anti-inflammatory and analgesic. It was shown to possess potent anti-apoptotic property. THE AIM OF THE STUDY: To evaluate the possible mechanism of action of isolated phytoconstituent from Madhuca indica Leaves methanolic extract (MI-ALC) on arsenic-induced cardiotoxicity in rats. MATERIALS AND METHODS: The 3,5,7,3',4'-Pentahydroxy flavone (QTN) was isolated and characterized by using HPTLC, (1)H NMR, and LC-MS from MI-ALC...
September 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28941929/minimizing-variance-in-care-of-pediatric-blunt-solid-organ-injury-through-utilization-of-a-hemodynamic-driven-protocol-a-multi-institution-study
#12
Aaron J Cunningham, Katrine M Lofberg, Sanjay Krishnaswami, Marilyn W Butler, Kenneth S Azarow, Nicholas A Hamilton, Elizabeth A Fialkowski, Pamela Bilyeu, Erika Ohm, Erin C Burns, Margo Hendrickson, Preetha Krishnan, Cynthia Gingalewski, Mubeen A Jafri
BACKGROUND: An expedited recovery protocol for management of pediatric blunt solid organ injury (spleen, liver, and kidney) was instituted across two Level 1 Trauma Centers, managed by nine pediatric surgeons within three hospital systems. METHODS: Data were collected for 18months on consecutive patients after protocol implementation. Patient demographics (including grade of injury), surgeon compliance, National Surgical Quality Improvement Program (NSQIP) complications, direct hospital cost, length of stay, time in the ICU, phlebotomy, and re-admission were compared to an 18-month control period immediately preceding study initiation...
September 4, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28941748/impact-of-triggering-events-on-outcomes-of-acute-heart-failure
#13
Yasuyuki Shiraishi, Shun Kohsaka, Takayuki Abe, Kazumasa Harada, Tetsuro Miyazaki, Takamichi Miyamoto, Kiyoshi Iida, Shuzou Tanimoto, Mayuko Yagawa, Makoto Takei, Yuji Nagatomo, Toru Hosoda, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama
BACKGROUND: The onset of acute heart failure is known to be associated with increased physical activity and other specific behaviors that can trigger hemodynamic deterioration. This analysis aimed to describe the distribution of triggers in patients hospitalized for acute heart failure, and investigate their effects on in-hospital outcomes. METHODS: Consecutive patients hospitalized for acute heart failure between 2010-2014 were registered in a multicenter data registration system (72 institutions within Tokyo, Japan)...
September 20, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28941078/the-effectiveness-and-safety-of-the-impella-ventricular-assist-device-for-high-risk-percutaneous-coronary-interventions-a-systematic-review
#14
Jamal Ait Ichou, Natasha Larivée, Mark J Eisenberg, Karine Suissa, Kristian B Filion
BACKGROUND: Small randomized controlled trials (RCTs) and observational studies have examined the effectiveness and safety of the Impella device, a percutaneous left ventricular assist device, in the setting of high-risk percutaneous coronary intervention (PCI). However, data are sparse and results are conflicting. Our objective was to evaluate the effectiveness and safety of the Impella device in high-risk patients undergoing PCI via a systematic review of the literature. METHODS: We searched Medline, EMBASE, and the Cochrane Library for RCTs and observational studies that evaluated the Impella device in high-risk patients undergoing PCI...
September 20, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28940794/percutaneous-pulmonary-valve-implantation-for-reconstruction-of-a-patch-repaired-right-ventricular-outflow-tract
#15
Anoosh Esmaeili, Simone Bollmann, Markus Khalil, Roberta De Rosa, Stephan Fichtlscherer, Hakan Akintuerk, Dietmar Schranz
Percutaneous pulmonary valve implantation (PPVI) is nowadays an accepted treatment option to repair post-surgical conduit dysfunction of the right ventricular outflow tract (RVOT). In addition, many patients need a pulmonary valve to reconstruct a hemodynamically incompetent native or conduit free outflow tract. Based on our experience with percutaneous stent-valve placement in a cohort of 125 patients, we report here transvenous reconstruction of a conduit-free, patch repaired outflow tract by utilizing balloon-expandable stent-valves in 23 patients with a median age of 22 years (5-60 years)...
September 20, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28940567/perioperative-fluid-and-hemodynamic-management-within-an-enhanced-recovery-pathway
#16
REVIEW
Michael W Manning, William Jonathan Dunkman, Timothy E Miller
Goal-directed fluid therapy (GDFT) seeks to improve outcomes through individualized optimization of oxygen delivery using IV fluid and vasoactive infusions. Trials of GDFT show clinical benefits over traditional liberal fluid administration, but fail to demonstrate benefits when compared to a restrictive strategy within an optimized enhanced recovery protocol. The ideal monitors, hemodynamic goals, and fluid administration strategy are not well established but may be less important than rational application of thoughtful fluid management strategies...
September 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28940550/evaluation-of-combined-extracorporeal-life-support-and-continuous-renal-replacement-therapy-on-hemodynamic-performance-and-gaseous-microemboli-handling-ability-in-a-simulated-neonatal-ecls-system
#17
Kaitlyn R Shank, Elizabeth Profeta, Shigang Wang, Christian O'Connor, Allen R Kunselman, Karl Woitas, John L Myers, Akif Ündar
The objective of this study was to evaluate the hemodynamic performance and gaseous microemboli (GME) handling ability of a simulated neonatal extracorporeal life support (ECLS) circuit with an in-line continuous renal replacement therapy (CRRT) device. The circuit consisted of a Maquet RotaFlow centrifugal pump or HL20 roller pump, Quadrox-iD Pediatric diffusion membrane oxygenator, 8-Fr arterial cannula, 10-Fr venous cannula, and Better-Bladder (BB) with "Y" connector. A second Quadrox-I Adult oxygenator was added postarterial cannula for GME experiments...
September 21, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28939932/prognostic-value-of-selected-echocardiographic-impedance-cardiographic-and-hemodynamic-parameters-determined-during-right-heart-catheterization-in-patients-qualified-for-heart-transplantation
#18
Wojciech Gilewski, Jarosław Pietrzak, Joanna Banach, Robert Bujak, Jan Błażejewski, Danuta Karasek, Łukasz Wołowiec, Władysław Sinkiewicz
The aim of the study was to verify prognostic value of selected echocardiographic (UKG), impedance cardiography (ICG), and right heart catheterization (RHC) parameters in systolic heart failure (HF). UKG, ICG, and RHC were performed in 46 patients with chronic HF with ejection fraction <35%. During a 1-year follow-up, composite endpoint (death or hospitalization due to HF exacerbation) was achieved by 23 (50.0%) patients. Analysis of receiver operating characteristic (ROC) curves identified UKG parameters: inferior vena cava diameter on inspiration (IVCinsp) >13 mm [area under curve (AUC), 0...
September 22, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28939710/hemodynamic-profile-of-patients-with-heart-failure-and-preserved-ejection-fraction-vary-by-age
#19
Shane Nanayakkara, Mark Haykowsky, Justin Mariani, Vanessa Van Empel, Micha T Maeder, Donna Vizi, David M Kaye
BACKGROUND: Patients with heart failure with preserved ejection fraction (HFpEF) exhibit a range of cardiovascular phenotypic profiles modified by several common comorbidities. In particular, patients with HFpEF tend to be older; however, it is unclear whether the effects of cardiovascular aging per se modify the expression of HFpEF. We therefore sought to investigate the interaction between age and physiologic profile in patients with HFpEF. METHODS AND RESULTS: We assessed the hemodynamic and metabolic profile of 40 patients with HFpEF...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28939650/muscle-sympathetic-nerve-responses-to-passive-and-active-one-legged-cycling-insight-into-the-contributions-of-central-command
#20
Connor J Doherty, Anthony V Incognito, Karambir Notay, Matthew J Burns, Joshua T Slysz, Jeremy D Seed, Massimo Nardone, Jamie F Burr, Philip J Millar
The contribution of central command to the peripheral vasoconstrictor response during exercise has been investigated using primarily handgrip exercise. The purpose of the present study was to compare muscle sympathetic nerve activity (MSNA) responses during passive (involuntary) and active (voluntary) zeroload cycling to gain insight into the effects of central command on sympathetic outflow during dynamic exercise. Hemodynamic measurements and contralateral leg MSNA (microneurography) were collected in eighteen young healthy participants at rest and during 2 minutes of passive and active zeroload one-legged cycling...
September 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
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