Marie Süße, Christine Kloetzer, Sebastian Strauß, Johanna Ruhnau, Lucas Hendrik Overeem, Merle Bendig, Juliane Schulze, Uwe Reuter, Antje Vogelgesang, Robert Fleischmann
BACKGROUND: To date, migraine is diagnosed exclusively based on clinical criteria, but fluid biomarkers are desirable to gain insight into pathophysiological processes and inform clinical management. We investigated the state-dependent profile of fluid biomarkers for neuroaxonal damage and microglial activation as two potentially relevant aspects in human migraine pathophysiology. METHODS: This exploratory study included serum and cerebrospinal fluid (CSF) samples of patients with migraine during the headache phase (ictally) (n = 23), between attacks (interictally) (n = 16), and age/sex-matched controls (n = 19)...
April 2, 2024: Journal of Headache and Pain