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Breast spectroscopy

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https://www.readbyqxmd.com/read/28422067/synthesis-characterization-antimicrobial-and-antiproliferative-activity-evaluation-of-cu-ii-co-ii-zn-ii-ni-ii-and-pt-ii-complexes-with-isoniazid-derived-compound
#1
Elena Pahonțu, Diana-Carolina Ilieș, Sergiu Shova, Camelia Oprean, Virgil Păunescu, Octavian Tudorel Olaru, Flavian Ștefan Rădulescu, Aurelian Gulea, Tudor Roșu, Doina Drăgănescu
Hydrazone complexes of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) with N-isonicotinoyl-N'-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as IR (infrared), ¹H-NMR and (13)C-NMR (hydrogen and carbon nuclear magnetic resonance, UV-Vis (ultraviolet-visible), FAB (fast atom bombardment), EPR (electron paramagnetic resonance), and mass spectroscopies...
April 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28419079/predicting-breast-cancer-response-to-neoadjuvant-chemotherapy-using-pretreatment-diffuse-optical-spectroscopic-texture-analysis
#2
William T Tran, Mehrdad J Gangeh, Lakshmanan Sannachi, Lee Chin, Elyse Watkins, Silvio G Bruni, Rashin Fallah Rastegar, Belinda Curpen, Maureen Trudeau, Sonal Gandhi, Martin Yaffe, Elzbieta Slodkowska, Charmaine Childs, Ali Sadeghi-Naini, Gregory J Czarnota
BACKGROUND: Diffuse optical spectroscopy (DOS) has been demonstrated capable of monitoring response to neoadjuvant chemotherapy (NAC) in locally advanced breast cancer (LABC) patients. In this study, we evaluate texture features of pretreatment DOS functional maps for predicting LABC response to NAC. METHODS: Locally advanced breast cancer patients (n=37) underwent DOS breast imaging before starting NAC. Breast tissue parametric maps were constructed and texture analyses were performed based on grey-level co-occurrence matrices for feature extraction...
April 18, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28415762/metabonomics-studies-on-serum-and-urine-of-patients-with-breast-cancer-using-1h-nmr-spectroscopy
#3
Jianping Zhou, Yanxia Wang, Xinli Zhang
The aim of this study was to describe a metabolomic study of breast cancer using 1H-NMR combined with bioinformatics analysis. 1H-NMR spectroscopy combined with multi-variate pattern recognition analysis was used to cluster the groups (serum and urine samples from breast cancer patients and healthy controls) and establish a breast-cancer-specific metabolites phenotype. Orthogonalpartial least-squares discriminant analysis (OPLS-DA) was capable of distinguishing serum and urine samples from breast cancer patients and healthy controls and establishing a breast-cancer-specific metabolite profile...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402286/longitudinal-optical-monitoring-of-blood-flow-in-breast-tumors-during-neoadjuvant-chemotherapy
#4
Jeffrey Martin Cochran, So Chung, Anaïs Leproux, Wesley Baker, David Busch, Angela DeMichele, Julia Tchou, Bruce Tromberg, Arjun Yodh
We measure tissue blood flow markers in breast tumors during neoadjuvant chemotherapy and investigate their correlation to pathologic complete response in a pilot longitudinal patient study (n=4). Tumor blood flow is quantified optically by diffuse correlation spectroscopy (DCS), and tissue optical properties, blood oxygen saturation, and total hemoglobin concentration are derived from concurrent diffuse optical spectroscopic imaging (DOSI). The study represents the first longitudinal DCS measurement of neoadjuvant chemotherapy in humans over the entire course of treatment; it therefore offers a first correlation between DCS flow indices and pathologic complete response...
April 12, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28393905/metabolomic-characterisation-of-the-effects-of-oncogenic-pik3ca-transformation-in-a-breast-epithelial-cell-line
#5
Chung-Ho E Lau, Gregory D Tredwell, James K Ellis, Eric W-F Lam, Hector C Keun
Somatic mutations in PIK3CA are frequently found in a number of human cancers, including breast cancer, altering cellular physiology and tumour sensitivity to chemotherapy. This renders PIK3CA an attractive molecular target for early detection and personalised therapy. Using (1)H Nuclear Magnetic Resonance spectroscopy (NMR) and Gas Chromatography - Mass Spectrometery (GC-MS) together with (13)C stable isotope-labelled glucose and glutamine as metabolic tracers, we probed the phenotypic changes in metabolism following a single copy knock-in of mutant PIK3CA (H1047R) in the MCF10A cell line, an important cell model for studying oncogenic transformation in breast tissues...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28393160/dielectric-spectroscopy-platform-to-measure-mcf10a-epithelial-cell-aggregation-as-a-model-for-spheroidal-cell-cluster-analysis
#6
K L Heileman, M Tabrizian
3-Dimensional cell cultures are more representative of the native environment than traditional cell cultures on flat substrates. As a result, 3-dimensional cell cultures have emerged as a very valuable model environment to study tumorigenesis, organogenesis and tissue regeneration. Many of these models encompass the formation of cell aggregates, which mimic the architecture of tumor and organ tissue. Dielectric impedance spectroscopy is a non-invasive, label free and real time technique, overcoming the drawbacks of established techniques to monitor cell aggregates...
April 10, 2017: Analyst
https://www.readbyqxmd.com/read/28384703/mapping-breast-cancer-blood-flow-index-composition-and-metabolism-in-a-human-subject-using-combined-diffuse-optical-spectroscopic-imaging-and-diffuse-correlation-spectroscopy
#7
Hossein S Yazdi, Thomas D O'Sullivan, Anais Leproux, Brian Hill, Amanda Durkin, Seraphim Telep, Jesse Lam, Siavash S Yazdi, Alice M Police, Robert M Carroll, Freddie J Combs, Tomas Strömberg, Arjun G Yodh, Bruce J Tromberg
No abstract text is available yet for this article.
April 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28379746/optical-imaging-of-the-breast-basic-principles-and-clinical-applications
#8
Giovanni Di Di Leo, Rubina Manuela Trimboli, Tamar Sella, Francesco Sardanelli
OBJECTIVE: The objective of this article is to summarize the physical principles, technology features, and first clinical applications of optical imaging techniques to the breast. CONCLUSION: Light-breast tissue interaction is expressed as absorption and scattering coefficients, allowing image reconstruction based on endogenous or exogenous contrast. Diffuse optical spectroscopy and imaging, fluorescence molecular tomography, photoacoustic imaging, and multiparametric infrared imaging show potential for clinical application, especially for lesion characterization, estimation of cancer probability, and monitoring the effect of neoadjuvant therapy...
April 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28379688/effects-of-doxorubicin-cisplatin-and-tamoxifen-on-the-metabolic-profile-of-human-breast-cancer-mcf-7-cells-as-determined-by-1-h-high-resolution-magic-angle-spinning-nuclear-magnetic-resonance
#9
Roberta M Maria, Wanessa F Altei, Heloisa S Selistre-de-Araujo, Luiz A Colnago
Doxorubicin (Doxo), cisplatin (Cis), and tamoxifen (Tamo) are part of many chemotherapeutic regimens. However, there have been limited studies of the way metabolism in breast cancer is affected by chemotherapy. We studied, through (1)H high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy, the metabolic profile of human breast cancer MCF-7 control (Con) cells as well as MCF-7 cells treated with Tamo, Cis, and Doxo. (1)H HR-MAS NMR single-pulse spectra evidenced signals from the cell compounds, including fatty acids (membranes), water-soluble proteins, and metabolites...
April 12, 2017: Biochemistry
https://www.readbyqxmd.com/read/28363567/development-of-a-new-type-of-multifunctional-fucoidan-based-nanoparticles-for-anticancer-drug-delivery
#10
Kun-Ying Lu, Rou Li, Chun-Hua Hsu, Cheng-Wei Lin, Shen-Chieh Chou, Min-Lang Tsai, Fwu-Long Mi
Fucoidan, a sulfated marine polysaccharide, has many potential biological functions, including anticancer activity. Recently, fucoidan has been reported to target P-selectin expressed on metastatic cancer cells. Increasing research attention has been devoted to the developments of fucoidan-based nanomedicine. However, the application of traditional chitosan/fucoidan nanoparticles in anticancer drug delivery may be limited due to the deprotonation of chitosan at a pH greater than 6.5. In this study, a mutli-stimuli-responsive nanoparticle self-assembled by fucoidan and a cationic polypeptide (protamine) was developed, and their pH-/enzyme-responsive properties were characterized by circular dichroism (CD) spectroscopy, dynamic light scattering (DLS), and zeta potential analysis...
June 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28338288/a-comparison-inhibitory-effects-of-cisplatin-and-mnps-peg-cisplatin-on-the-adhesion-capacity-of-bone-metastatic-breast-cancer
#11
Mohammad Javad Mokhtari, Fatemeh Koohpeima, Hadi Mohammadi
To date, high mortality in women due to malignancy breast cancer related to the metastasis to the bone is a significant challenge. Since, magnetic nanoparticles (MNPs) conjugated with the biocompatible polymers was employed for the delivery of some hydrophobic anti-cancer agents, so the main aim of the current research was to assess whether cisplatin-loaded MNPs enhanced the anti-cancer effect of free cisplatin in breast cancer cells.MNPs decorated with PEG were synthesized by an improved co-precipitation technique, and then cisplatin was loaded onto the MNPs via a simple mixing method...
March 24, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28336408/synthesis-properties-antitumor-and-antibacterial-activity-of-new-pt-ii-and-pd-ii-complexes-with-2-2-dithiobis-benzothiazole-ligand
#12
Simona Rubino, Rosalia Busà, Alessandro Attanzio, Rosa Alduina, Vita Di Stefano, Maria Assunta Girasolo, Santino Orecchio, Luisa Tesoriere
Mono- and binuclear Pt(II) and Pd(II) complexes with 2,2'-dithiobis(benzothiazole) (DTBTA) ligand are reported. [Pt(DTBTA)(DMSO)Cl]Cl∙CHCl3 (1) and [Pd2(µ-Cl)2(DTBTA)2]Cl2 (2) have been synthesized and structurally characterized by elemental analysis, IR, (1)H and (13)C NMR spectroscopy, MS spectrometry and the content of platinum and palladium was determined using a flame atomic spectrometer. Two different coordination modes of 1 and 2 complexes were found; in both complexes, the coordination of Pt(II) and Pd(II) ions involves the N(3) atoms of the ligand but the binuclear complex 2, is a cis-chloro-bridged palladium complex...
March 9, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28335206/cytotoxic-induction-and-photoacoustic-imaging-of-breast-cancer-cells-using-astaxanthin-reduced-gold-nanoparticles
#13
Subramaniyan Bharathiraja, Panchanathan Manivasagan, Nhat Quang Bui, Yun-Ok Oh, In Gweon Lim, Suhyun Park, Junghwan Oh
Astaxanthin, a kind of photosynthetic pigment, was employed for gold nanoparticle formation. Nanoparticles were characterized using Ulteraviolet-Visible (UV-Vis) spectroscopy, transmission electron microscopy, and X-ray diffraction, and the possible presence of astaxanthin functional groups were analyzed by Fourier transform infrared spectroscopy (FTIR). The cytotoxic effect of synthesized nanoparticles was evaluated against MDA-MB-231 (human breast cancer cells) using a tetrazolium-based assay, and synthesized nanoparticles exhibited dose-dependent toxicity...
April 20, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28323051/anticancer-and-anti-angiogenic-activities-of-extract-from-actinidia-eriantha-benth-root
#14
Jian-Guo Wu, Li Ma, Shui-Hua Lin, Yan-Bin Wu, Jun Yi, Bin-Jun Yang, Jin-Zhong Wu, Ka-Hing Wong
ETHNOPHARMACOLOGICAL RELEVANCE: The roots of Actinidia eriantha Benth (AER) are commonly used traditional folk medicine for the treatment of gastric carcinoma, nasopharyngeal carcinoma, and breast carcinoma. Besides, the anti-proliferative and immunomodulatory effects of AER polysaccharides on tumor-bearing mice have been reported previously. AIM OF THE STUDY: This work was carried out to investigate the anticancer and anti-angiogenic activities of AER. MATERIALS AND METHODS: The growth inhibitory effects of ethanol extracts from the leaves (EEL), stems (EES) and roots (EER) of A...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28316409/facile-synthesis-of-multifunctional-silver-nanoparticles-using-mangrove-plant-excoecaria-agallocha-l-for-its-antibacterial-antioxidant-and-cytotoxic-effects
#15
R Bhuvaneswari, R John Xavier, M Arumugam
The current study describes a simple, rapid and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) using Excoecaria agallocha (E. agallocha) leaf extract as stabilizer, bioreductant and capping agent. Synthesized AgNPs were characterized by UV-Visible spectroscopy (UV-Vis), X-ray diffraction (XRD), fourier transform infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDX). Generation of AgNPs was initially confirmed with the color change from yellow to dark brown which produces intense absorbance spectra at 440 nm in UV-Vis spectroscopy without any shifting of peaks...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28290700/metabolic-response-to-everolimus-in-patient-derived-triple-negative-breast-cancer-xenografts
#16
Leslie R Euceda, Deborah K Hill, Endre Stokke, Rana Hatem, Rania El Botty, Ivan Bièche, Elisabetta Marangoni, Tone F Bathen, Siver A Moestue
Patients with triple-negative breast cancer (TNBC) are unresponsive to endocrine and anti-HER2 pharmacotherapy, limiting their therapeutic options to chemotherapy. TNBC is frequently associated with abnormalities in the PI3K/AKT/mTOR signaling pathway; drugs targeting this pathway are currently being evaluated in these patients. However, the response is variable, partly due to heterogeneity within TNBC, conferring a need to identify biomarkers predicting response and resistance to targeted therapy. In this study, we used a metabolomics approach to assess response to the mTOR inhibitor everolimus in a panel of TNBC patient-derived xenografts (PDX) (n = 103 animals)...
April 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28290674/copper-i-phosphine-polypyridyl-complexes-synthesis-characterization-dna-hsa-binding-study-and-antiproliferative-activity
#17
Wilmer Villarreal, Legna Colina-Vegas, Gonzalo Visbal, Oscar Corona, Rodrigo S Corrêa, Javier Ellena, Marcia Regina Cominetti, Alzir Azevedo Batista, Maribel Navarro
A series of copper(I)-phosphine polypyridyl complexes have been investigated as potential antitumor agents. The complexes [Cu(PPh3)2dpq]NO3 (2), [Cu(PPh3)2dppz]NO3 (3), [Cu(PPh3)2dppa]NO3 (4), and [Cu(PPh3)2dppme]NO3 (5) were synthesized by the reaction of [Cu(PPh3)2NO3] with the respective planar ligand under mild conditions. These copper complexes were fully characterized by elemental analysis, molar conductivity, FAB-MS, and NMR, UV-vis, and IR spectroscopies. Interactions between these copper(I)-phosphine polypyridyl complexes and DNA have been investigated using various spectroscopic techniques and analytical methods, such as UV-vis titrations, thermal denaturation, circular dichroism, viscosity measurements, gel electrophoresis, and competitive fluorescent intercalator displacement assays...
April 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28290213/cardamom-fruits-as-a-green-resource-for-facile-synthesis-of-gold-and-silver-nanoparticles-and-their-biological-applications
#18
Veronika Soshnikova, Yeon Ju Kim, Priyanka Singh, Yue Huo, Josua Markus, Sungeun Ahn, Verónica Castro-Aceituno, Jongpyo Kang, Mohan Chokkalingam, Ramya Mathiyalagan, Deok Chun Yang
Gold (FA-AuNps) and silver (FA-AgNps) nanoparticles were synthesized at room temperature by aqueous extract of dried fruits of Amomum villosum, also known as Fructus Amomi (cardamom), in order to confer antioxidant, catalytic, antimicrobial activities and treatment effect against breast cancer cells. Fruit extracts served as both reducing agents and stabilizers in lieu of chemical agents. Ultra-violet visible (UV-Vis) spectroscopy, field emission transmission electron microscopy (FE-TEM), energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, X-ray powder diffraction (XRD), selected area electron diffraction (SAED), dynamic light scattering (DLS) and Fourier transform infrared (FTIR) spectroscopy were employed to characterize the biosynthesized nanoparticles...
March 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28282562/synthesis-characterization-and-biological-evaluation-of-ruthenium-flavanol-complexes-against-breast-cancer
#19
Ashok Kumar Singh, Gunjan Saxena, Sahabjada, M Arshad
Four Ru(II) DMSO complexes (M1R-M4R) having substituted flavones viz. 3-Hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one (HL1), 3-Hydroxy-2-(4-nitrophenyl)-4H-chromen-4-one (HL2), 3-Hydroxy-2-(4-dimethylaminophenyl)-4H-chromen-4-one (HL3) and 3-Hydroxy-2-(4-chlorophenyl)-4H-chromen-4-one (HL4) were synthesized and characterized by elemental analysis, IR, UV-Vis, (1)H NMR spectroscopies and ESI-MS. The molecular structures of the complexes were investigated by integrated spectroscopic and computational techniques (DFT)...
March 1, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28281359/changes-in-skin-microcirculation-during-radiation-therapy-for-breast-cancer
#20
Erik Tesselaar, Anna M Flejmer, Simon Farnebo, Alexandru Dasu
BACKGROUND: The majority of breast cancer patients who receive radiation treatment are affected by acute radiation-induced skin changes. The assessment of these changes is usually done by subjective methods, which complicates the comparison between different treatments or patient groups. This study investigates the feasibility of new robust methods for monitoring skin microcirculation to objectively assess and quantify acute skin reactions during radiation treatment. MATERIAL AND METHODS: Laser Doppler flowmetry, laser speckle contrast imaging, and polarized light spectroscopy imaging were used to measure radiation-induced changes in microvascular perfusion and red blood cell concentration (RBC) in the skin of 15 patients undergoing adjuvant radiation therapy for breast cancer...
March 10, 2017: Acta Oncologica
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