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https://www.readbyqxmd.com/read/28644842/investigation-of-discriminant-metabolites-in-tamoxifen-resistant-and-choline-kinase-alpha-downregulated-breast-cancer-cells-using-1h-nuclear-magnetic-resonance-spectroscopy
#1
Hoe Suk Kim, Lianji Tian, Hyeonjin Kim, Woo Kyung Moon
Metabolites linked to changes in choline kinase-α (CK-α) expression and drug resistance, which contribute to survival and autophagy mechanisms, are attractive targets for breast cancer therapies. We previously reported that autophagy played a causative role in driving tamoxifen (TAM) resistance of breast cancer cells (BCCs) and was also promoted by CK-α knockdown, resulting in the survival of TAM-resistant BCCs. There is no comparative study yet about the metabolites resulting from BCCs with TAM-resistance and CK-α knockdown...
2017: PloS One
https://www.readbyqxmd.com/read/28639300/multiparametric-mri-of-the-breast-a-review
#2
REVIEW
Maria Adele Marino, Thomas Helbich, Pascal Baltzer, Katja Pinker-Domenig
During their development, cancers acquire several functional capabilities, which are defined as the hallmarks of cancer. For a deeper understanding of the hallmarks of cancer, and, consequently, improved personalized patient care, diagnostic tests must be multilayered and complex to identify the relevant underlying processes of cancer development and progression. In this context, magnetic resonance imaging (MRI) has emerged as an exceptionally powerful, versatile, and precise imaging technique. MRI of the breast is an essential tool in breast imaging, with multiple indications...
June 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28636317/downsizing-proto-oncogene-cfos-to-short-helix-constrained-peptides-that-bind-jun
#3
Daniel Baxter, Samuel R Perry, Timothy A Hill, W Mei Kok, Nathan R Zaccai, R Leo Brady, David P Fairlie, Jody M Mason
The oncogenic transcription factor activator protein-1 (AP-1) is a DNA-binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled-coil structure. This study reports on downsizing the proto-oncogene cFos protein (380 residues) to shorter peptides (37-25 residues) modified with helix-inducing constraints to enhance binding to Jun. A crystal structure is reported for a 37-residue Fos-derived peptide (FosW) bound to Jun. This guided iterative downsizing of FosW to shorter peptide sequences that were constrained into stable water-soluble α-helices by connecting amino acid side chains to form cyclic pentapeptide components...
June 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28635141/high-sensitivity-non-invasive-detection-of-calcifications-deep-inside-biological-tissue-using-transmission-raman-spectroscopy
#4
Adrian Ghita, Pavel Matousek, Nick Stone
The aim of this research was to develop a novel approach to probe non-invasively the composition of inorganic chemicals buried deep in large volume biological samples. The method is based on advanced Transmission Raman Spectroscopy (TRS) permitting chemical specific detection within a large sampling volume. The approach could be beneficial to chemical identification of the breast calcifications detected during mammographic X-ray procedures. The chemical composition of a breast calcification reflects the pathology of the surrounding tissue, malignant or benign and potentially the grade of malignancy...
June 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28629019/methotrexate-loaded-nitrogen-doped-graphene-quantum-dots-nanocarriers-as-an-efficient-anticancer-drug-delivery-system
#5
Fatemeh Khodadadei, Shahrokh Safarian, Narges Ghanbari
Graphene quantum dots (GQDs) are new efficient nanomaterials used in therapeutic applications. In this study, blue fluorescent nitrogen-doped GQDs (N-GQDs) were synthesized by a hydrothermal method via pyrolisis of citric acid as the carbon source and urea as the nitrogen source. The existence of doped nitrogen in GQDs was confirmed by FTIR characterization. Here, for the first time, the N-GQDs were loaded with the anticancer drug, methotrexate (MTX), to prepare MTX-(N-GQDs) as an efficient drug delivery system...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28626257/multi-center-rater-blinded-study-of-early-intervention-with-the-hand-incubator-for-breast-cancer-related-lymphedema-the-beat-edema-trial-proposal-of-a-research-protocol
#6
Hisao Ishii, Katsuyuki Iwatsuki, Masahiro Tatebe, Hitoshi Hirata, Toyone Kikumori, Nobuyuki Tsunoda, Ikuo Hyodo, Tomoko Ogawa, Naoki Unno
Postoperative lymphedema is considered irreversible once it has developed, and significantly lowers the patient's quality of life. However, lymphatic function has recently been clarified, and it is possible that lymphedema can be cured if early treatment is started. This two-arm randomized clinical trial (UMIN000026124) will prospectively evaluate 24 patients with early-stage breast cancer-related lymphedema at the Nagoya University Hospital and Aichi Cancer Center Hospital. The eligibility criteria will be patients who are diagnosed with stage 0-1 breast cancer-related lymphedema, as defined by the International Society of Lymphology, within 12 weeks after breast cancer surgery...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28624020/a-new-method-to-reduce-false-positive-results-in-breast-mri-by-evaluation-of-multiple-spectral-regions-in-proton-mr-spectroscopy
#7
Paola Clauser, Magda Marcon, Matthias Dietzel, Pascal A T Baltzer
OBJECTIVES: To investigate whether the evaluation of multiple spectral regions can increase the diagnostic performance of (1)H-MRS of the breast and reduce false positive findings. METHODS: 93 patients (mean age 56 years, range 23-79) undergoing breast MRI for routine clinical indications on a 1.5T scanner were eligible for this IRB-approved prospective study. Suspicious enhancing lesions ≥8mm underwent single-voxel point-resolved (1)H-MRS (PRESS, TR=2000ms, TE=272ms)...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28623723/dft-b3lyp-calculations-in-vitro-cytotoxicity-and-antioxidant-activities-of-steroidal-pyrimidines-and-their-interaction-with-hsa-using-molecular-docking-and-multispectroscopic-techniques
#8
Abad Ali, Mohd Asif, Parvez Alam, Mohammad Jane Alam, Mohd Asif Sherwani, Rizwan Hasan Khan, Shabbir Ahmad, Shamsuzzaman
As a part of our continuing program on the synthesis of steroidal heterocycles, it has been prepared a series of novel steroidal pyrimidine derivatives 4-6via TMSCl, steroidal ketones (1c-3c), urea and benzaldehyde. The systems presented here, are novel scaffolds and have not been described before at 6th position of steroidal-6-one (1c-3c). Structural assignment of newly synthesized compounds was performed by DFT/B3LYP calculations as well as spectral and analytical data. The interactions of compounds (4-6) with HSA were studied by fluorescence spectroscopy, DLS, CD and molecular docking, under imitated physiological conditions...
June 14, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28620481/tolerability-and-safety-of-the-intake-of-bovine-milk-oligosaccharides-extracted-from-cheese-whey-in-healthy-human-adults
#9
Jennifer T Smilowitz, Danielle G Lemay, Karen M Kalanetra, Elizabeth L Chin, Angela M Zivkovic, Melissa A Breck, J Bruce German, David A Mills, Carolyn Slupsky, Daniela Barile
Mechanistic research suggests a unique evolutionary relationship between complex milk oligosaccharides and cognate bifidobacteria enriched in breast-fed infants. Bovine milk oligosaccharides (BMO) were recently identified as structurally and functionally similar to human milk oligosaccharides. The present single-blind three-way crossover study is the first to determine the safety and tolerability of BMO consumption by healthy human participants (n 12) and its effects on faecal microbiota and microbial metabolism...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28618342/monitoring-breast-cancer-treatment-using-a-fourier-transform-infrared-spectroscopy-based-computational-model
#10
J Depciuch, E Kaznowska, S Golowski, A Koziorowska, I Zawlik, M Cholewa, K Szmuc, J Cebulski
Breast cancer affects one in four women, therefore, the search for new diagnostic technologies and therapeutic approaches is of critical importance. This involves the development of diagnostic tools to facilitate the detection of cancer cells, which is useful for assessing the efficacy of cancer therapies. One of the major challenges for chemotherapy is the lack of tools to monitor efficacy during the course of treatment. Vibrational spectroscopy appears to be a promising tool for such a purpose, as it yields Fourier transformation infrared (FTIR) spectra which can be used to provide information on the chemical composition of the tissue...
June 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28611296/does-the-1h-nmr-plasma-metabolome-reflect-the-host-tumor-interactions-in-human-breast-cancer
#11
Vincent Richard, Raphaël Conotte, David Mayne, Jean-Marie Colet
Breast cancer (BC) is the most common diagnosed cancer and the leading cause of cancer death in women worldwide. There is an obvious need for a better understanding of BC biology. Alterations in the serum metabolome of BC patients have been identified but their clinical significance remains elusive. We evaluated by 1H-Nuclear Magnetic Resonance (1H-NMR) spectroscopy, filtered plasma metabolome of 50 early (EBC) and 15 metastatic BC (MBC) patients. Using Principal Component Analysis, Partial Least-Squares Discriminant Analysis and Hierarchical Clustering we show that plasma levels of glucose, lactate, pyruvate, alanine, leucine, isoleucine, glutamate, glutamine, valine, lysine, glycine, threonine, tyrosine, phenylalanine, acetate, acetoacetate, β-hydroxy-butyrate, urea, creatine and creatinine are modulated across patients clusters...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28602290/a-sensitive-and-disposable-electrochemical-immunosensor-for-detection-of-sox2-a-biomarker-of-cancer
#12
Elif Burcu Aydın, Mustafa Kemal Sezgintürk
A novel, sensitive, disposable indium tin oxide (ITO)-based electrochemical immunosensor was developed firstly for simple, rapid determination of Sex-determining region Y-box 2 (SOX2). SOX2 is a cancer biomarker and used for detecting small cell lung cancer, lung adenocarcinoma, squamous cell carcinoma, skin cancer, prostate cancer, and breast cancer. In this study, a disposable ITO thin film based electrode was used as working electrode for biosensing the interaction between SOX2 antigen and anti-SOX2 antibody...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28601058/in-vitro-study-of-spions-c595-as-molecular-imaging-probe-for-specific-breast-cancer-mcf-7-cells-detection
#13
Pegah Moradi Khaniabadi, Daryoush Shahbazi-Gahrouei, Amin Malik Shah Abdul Majid, Mohammad Suhaimi Jaafar, Bita Moradi Khaniabadi, Saghar Shahbazi-Gahrouei
Background: Magnetic resonance imaging (MRI) plays an essential role in molecular imaging by delivering the contrast agent into targeted cancer cells. The aim of this study was to evaluate the C595 monoclonal antibody-conjugated superparamagnetic iron oxide nanoparticles (SPIONs-C595) for the detection of breast cancer cell (MCF-7). Methods: The conjugation of monoclonal antibody and nanoparticles was confirmed using X-ray diffraction, transmission electron microscopy, and photon correlation spectroscopy...
June 11, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28590405/breast-tissue-metabolism-by-magnetic-resonance-spectroscopy
#14
REVIEW
Naranamangalam R Jagannathan, Uma Sharma
Metabolic alterations are known to occur with oncogenesis and tumor progression. During malignant transformation, the metabolism of cells and tissues is altered. Cancer metabolism can be studied using advanced technologies that detect both metabolites and metabolic activities. Identification, characterization, and quantification of metabolites (metabolomics) are important for metabolic analysis and are usually done by nuclear magnetic resonance (NMR) or by mass spectrometry. In contrast to the magnetic resonance imaging that is used to monitor the tumor morphology during progression of the disease and during therapy, in vivo NMR spectroscopy is used to study and monitor tumor metabolism of cells/tissues by detection of various biochemicals or metabolites involved in various metabolic pathways...
June 7, 2017: Metabolites
https://www.readbyqxmd.com/read/28583007/biosynthesized-gold-and-silver-nanoparticles-by-aqueous-fruit-extract-of-chaenomeles-sinensis-and-screening-of-their-biomedical-activities
#15
Keun Hyun Oh, Veronika Soshnikova, Josua Markus, Yeon Ju Kim, Sang Chul Lee, Priyanka Singh, Verónica Castro-Aceituno, Sungeun Ahn, Dong Hyun Kim, Yeon Jae Shim, Yu Jin Kim, Deok Chun Yang
The design of mild and non-toxic synthesis of metallic nanoparticles is a topical subject in the nanotechnology field. The objective of this present study is to screen the bioactivity of biosynthesized nanoparticles by aqueous fruit extract of Chaenomeles sinensis. The reducing and stabilizing ability of C. sinensis to fabricate gold (Cs-AuNps) and silver (Cs-AgNps) nanoparticles was confirmed by UV-visible (UV-Vis) spectroscopy at 562 nm and 477 nm, respectively. The field-emission transmission electron microscopy (FE-TEM) and X-ray diffraction analysis (XRD) verify the nano-scale morphology and crystallinity of Cs-AuNps (20-40 nm) and Cs-AgNps (5-20 nm)...
June 6, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28581822/three-new-sesquiterpenes-from-pterocarpus-santalinus
#16
Li Li, Run-Hong Tao, Ji-Ming Wu, Ya-Ping Guo, Chao Huang, Hong-Gang Liang, Le-Zhi Fan, Hai-Yan Zhang, Ren-Kuan Sun, Lei Shang, Li-Na Lu, Jian Huang, Jin-Hui Wang
Three new sesquiterpenes of canusesnol K (1), canusesnol L (2) and 12, 15-dihydroxycurcumene (3), along with five known ones (4-8), were isolated from the heartwood extract of Pterocarpus santalinus. Their structures were established by extensive analyses of 1D and 2D NMR spectroscopy, including (1)H NMR, (13)C NMR, HSQC, HMBC and NOESY, and HRESI-MS. The absolute configurations of the new compounds were established with Modified Mosher's method. The cytotoxic activities of all these compounds against HepG2 (human liver cancer), MCF-7 (human breast cancer), MDA-MB-231 (human breast cancer), and Hela (human cervical carcinoma) cancer cell lines were evaluated...
June 5, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28574093/in-vitro-degradation-of-polydimethylsiloxanes-in-breast-implant-applications
#17
Nilza G Ramião, Pedro S Martins, Maria L Barroso, Diana C Santos, António A Fernandes
BACKGROUND: The durability of breast implant material is associated with failure probability, increasing with time from implantation. The current study avoided the bias introduced by biological factors, to systematically investigate the degradation over time of shell materials. The same fundamental physical and chemical conditions were maintained (temperature and pH) throughout the study, to decouple biological aspects from the degradation process. METHODS: Six virgin implants of 2 brands were submitted to the in vitro degradation process, mechanical testing of shell materials, surface change analysis (via scanning electron microscopy [SEM]) and chemical composition analysis by Fourier transform infrared (FTIR) spectroscopy...
May 24, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28570910/the-impact-of-anticancer-activity-upon-beta-vulgaris-extract-mediated-biosynthesized-silver-nanoparticles-ag-nps-against-human-breast-mcf-7-lung-a549-and-pharynx-hep-2-cancer-cell-lines
#18
K Venugopal, H Ahmad, E Manikandan, K Thanigai Arul, K Kavitha, M K Moodley, K Rajagopal, R Balabhaskar, M Bhaskar
The present study tried for a phyto-synthetic method of producing silver nanoparticles (Ag-NPs) with size controlled as and eco-friendly route that can lead to their advanced production with decorative tranquil morphology. By inducing temperature fluctuation of the reaction mixture from 25 to 80°C the plasmon resonance band raised slowly which had an ultimate effect on size and shape of Ag-NPs as shown by UV-visible spectroscopy and TEM results. The biosynthesized nanoparticles showed good cytotoxic impact against MCF-7, A549 and Hep2 cells compared to normal cell lines...
May 24, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28560871/forecasting-chronic-diseases-using-data-fusion
#19
Evrim Acar, Gözde Gürdeniz, Francesco Savorani, Louise Hansen, Anja Olsen, Anne Tjønneland, Lars Ove Dragsted, Rasmus Bro
Data fusion, that is, extracting information through the fusion of complementary data sets, is a topic of great interest in metabolomics because analytical platforms such as liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy commonly used for chemical profiling of biofluids provide complementary information. In this study, with a goal of forecasting acute coronary syndrome (ACS), breast cancer, and colon cancer, we jointly analyzed LC-MS, NMR measurements of plasma samples, and the metadata corresponding to the lifestyle of participants...
June 9, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28536451/revealing-chemical-processes-and-kinetics-of-drug-action-within-single-living-cells-via-plasmonic-raman-probes
#20
Shan-Shan Li, Qi-Yuan Guan, Gang Meng, Xiao-Feng Chang, Ji-Wu Wei, Peng Wang, Bin Kang, Jing-Juan Xu, Hong-Yuan Chen
Better understanding the drug action within cells may extend our knowledge on drug action mechanisms and promote new drugs discovery. Herein, we studied the processes of drug induced chemical changes on proteins and nucleic acids in human breast adenocarcinoma (MCF-7) cells via time-resolved plasmonic-enhanced Raman spectroscopy (PERS) in combination with principal component analysis (PCA). Using three popular chemotherapy drugs (fluorouracil, cisplatin and camptothecin) as models, chemical changes during drug action process were clearly discriminated...
May 23, 2017: Scientific Reports
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