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Breast spectroscopy

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https://www.readbyqxmd.com/read/28087479/synthesis-and-characterization-of-gold-nanostructured-chorin-e6-for-photodynamic-therapy
#1
L Vieira, M L Castilho, I Ferreira, J Ferreira-Strixino, K C Hewitt, L Raniero
Photodynamic therapy is an alternative treatment for cancer based on cellular uptake of a photosensitizer, illuminated with an appropriate wavelength in the presence of oxygen. A cascade of reactions generates reactive oxygen species leading to cell death. Using carbodiimide chemistry, chlorin e6 (Ce6) was covalently bonded to thiourea, and (via the sulphur end group) to gold nanoparticles (AuNPs), forming the Ce6-AuNP complex. Ce6 absorbs in the range 650-680nm, where the coefficient of biological tissue absorption is low (part of the therapeutic window), which is ideal for biological application...
January 10, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28069800/label-free-raman-spectroscopy-detects-stromal-adaptations-in-premetastatic-lungs-primed-by-breast-cancer
#2
Santosh Kumar Paidi, Asif Rizwan, Chao Zheng, Menglin Cheng, Kristine Glunde, Ishan Barman
Recent advances in animal modeling, imaging technology, and functional genomics have permitted precise molecular observations of the metastatic process. However, a comprehensive understanding of the premetastatic niche remains elusive, owing to the limited tools that can map subtle differences in molecular mediators in organ-specific microenvironments. Here, we report the ability to detect premetastatic changes in the lung microenvironment, in response to primary breast tumors, using a combination of metastatic mouse models, Raman spectroscopy, and multivariate analysis of consistent patterns in molecular expression...
November 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/28052025/cytotoxic-lanostane-type-triterpenoids-from-the-fruiting-bodies-of-ganoderma-lucidum-and-their-structure-activity-relationships
#3
Shaodan Chen, Xiangmin Li, Tianqiao Yong, Zhanggen Wang, Jiyan Su, Chunwei Jiao, Yizhen Xie, Burton B Yang
We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line HepG2. Corresponding three-dimensional quantitative structure-activity relationship (3D-QSAR) models were built and analyzed using Discovery Studio...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28048538/th-ab-209-05-validating-hemoglobin-saturation-and-dissolved-oxygen-in-tumors-using-photoacoustic-computed-tomographic-spectroscopic-imaging
#4
J Burnett, J Sick, N Cao, B Liu, H Nakshatri, M Mendonca, K Stantz
PURPOSE: Photoacoustic computed tomographic spectroscopy (PCT-S) provides intra-tumor measurements of oxygenation with high spatial resolution (0.2mm) and temporal fidelity (1-2 minutes) without the need for exogenous agents or ionizing radiation, thus providing a unique in vivo assay to measure SaO2 and investigate acute and chronic forms of hypoxia. The goal of this study is to validate in vivo SaO2 levels within tail artery of mice and the relationship between SaO2 and pO2 within subcutaneous breast tumors using PCT-S imaging, pulse oximetry and an OxyLite probe...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039786/dna-interaction-antimicrobial-antioxidant-and-anticancer-studies-on-cu-ii-complexes-of-luotonin-a
#5
M P Kesavan, G G Vinoth Kumar, J Dhaveethu Raja, K Anitha, S Karthikeyan, J Rajesh
Luotonin A (L), a novel natural cytotoxic and anti-inflammatory alkaloid, chelated with copper(II) to improve its cytotoxic effect against the cancer cells. The complexes [Cu(L)H2OCl]Cl (1) and [Cu(L)2]Cl2 (2) are prepared by using copper(II) chloride and L with ligand/metal molar ratio of 1:1 and 2:1 respectively. A solution of complexes 1 &2 are characterized by physical spectroscopic methods using Ultraviolet-visible (UV-Vis) spectrophotometer, Fourier Transform-Infra red (FT-IR) spectroscopy, Electron Para magnetic Resonance Spectroscopy (EPR) and by electrochemical methods...
December 22, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28032377/proton-and-phosphorus-magnetic-resonance-spectroscopy-of-the-healthy-human-breast-at-7%C3%A2-t
#6
Wybe J M van der Kemp, Bertine L Stehouwer, Vincent O Boer, Peter R Luijten, Dennis W J Klomp, Jannie P Wijnen
In vivo water- and fat-suppressed (1) H magnetic resonance spectroscopy (MRS) and (31) P magnetic resonance adiabatic multi-echo spectroscopic imaging were performed at 7 T in duplicate in healthy fibroglandular breast tissue of a group of eight volunteers. The transverse relaxation times of (31) P metabolites were determined, and the reproducibility of (1) H and (31) P MRS was investigated. The transverse relaxation times for phosphoethanolamine (PE) and phosphocholine (PC) were fitted bi-exponentially, with an added short T2 component of 20 ms for adenosine monophosphate, resulting in values of 199 ± 8 and 239 ± 14 ms, respectively...
December 28, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/28024936/nanotoxicity-of-cobalt-induced-by-oxidant-generation-and-glutathione-depletion-in-mcf-7-cells
#7
Mohd Javed Akhtar, Maqusood Ahamed, Hisham A Alhadlaq, Aws Alshamsan
There are very few studies regarding the biological activity of cobalt-based nanoparticles (NPs) and, therefore, the possible mechanism behind the biological response of cobalt NPs has not been fully explored. The present study was designed to explore the potential mechanisms of the cytotoxicity of cobalt NPs in human breast cancer (MCF-7) cells. The shape and size of cobalt NPs were characterized by scanning and transmission electron microscopy (SEM and TEM). The crystallinity of NPs was determined by X-ray diffraction (XRD)...
December 23, 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28018735/using-drs-during-breast-conserving-surgery-identifying-robust-optical-parameters-and-influence-of-inter-patient-variation
#8
Lisanne L de Boer, Benno H W Hendriks, Frederieke van Duijnhoven, Marie-Jeanne T F D Vrancken Peeters-Baas, Koen Van de Vijver, Claudette E Loo, Katarzyna Jóźwiak, Henricus J C M Sterenborg, Theo J M Ruers
Successful breast conserving surgery consists of complete removal of the tumor while sparing healthy surrounding tissue. Despite currently available imaging and margin assessment tools, recognizing tumor tissue at a resection margin during surgery is challenging. Diffuse reflectance spectroscopy (DRS), which uses light for tissue characterization, can potentially guide surgeons to prevent tumor positive margins. However, inter-patient variation and changes in tissue physiology occurring during the resection might hamper this light-based technology...
December 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/28006904/resin-glycosides-from-ipomoea-alba-seeds-as-potential-chemosensitizers-in-breast-carcinoma-cells
#9
Sara Cruz-Morales, Jhon Castañeda-Gómez, Daniel Rosas-Ramírez, Mabel Fragoso-Serrano, Gabriela Figueroa-González, Argelia Lorence, Rogelio Pereda-Miranda
Multidrug resistance is the expression of one or more efflux pumps, such as P-glycoprotein, and is a major obstacle in cancer therapy. The use of new potent and noncytotoxic efflux pump modulators, coadministered with antineoplastic agents, is an alternative approach for increasing the success rate of therapy regimes with different drug combinations. This report describes the isolation and structure elucidation of six new resin glycosides from moon vine seeds (Ipomoea alba) as potential mammalian multidrug-resistance-modifying agents...
December 23, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/28006663/studies-on-the-mechanism-of-action-of-antitumor-bis-aminophenolate-ruthenium-iii-complexes
#10
Orsolya Dömötör, Rodrigo F M de Almeida, Leonor Côrte-Real, Cristina P Matos, Fernanda Marques, António Matos, Carla Real, Tamás Kiss, Éva Anna Enyedy, M Helena Garcia, Ana Isabel Tomaz
Two recently published Ru(III) complexes bearing (N2O2) tetradentate bis(aminophenolate) ligands, formulated as [Ru(III)(salan)(PPh3)Cl] (salan is the tetradentate ligand 6,6'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(3-methoxyphenol) in complex 1, or 2,2'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(4-methoxyphenol) in complex 2; PPh3 is triphenylphosphane) and found very active against ovarian and breast adenocarcinoma human cells were studied to outline their antitumor mode of action...
December 14, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28000609/an-i-in-vitro-i-3d-model-using-collagen-coated-gelatin-nanofibers-for-studying-breast-cancer-metastasis
#11
Janani Guru, Mamatha Pillai, Selvakumar Rajendran, Amitava Bhattacharyya, Sabarinath Chandrasekharan
Study of breast cancer metastasis is limited due to poor knowledge in molecular progression of breast tumor and varied heterogeneity. For better understanding of tumor metastasis, a reliable 3D <i>in vitro</i> model bridging the gap between 2D cultures and <i>in vivo</i> animal model studies is highly needed. Our study is focused on two keypoints (i) designing a 3D microenvironment for studying metastasis and (ii) simulating the metastasis milieu by inducing epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET)...
December 21, 2016: Biofabrication
https://www.readbyqxmd.com/read/27981651/mr-spectroscopy-of-breast-cancer-for-assessing-early-treatment-response-results-from-the-acrin-6657-mrs-trial
#12
Patrick J Bolan, Eunhee Kim, Benjamin A Herman, Gillian M Newstead, Mark A Rosen, Mitchell D Schnall, Etta D Pisano, Paul T Weatherall, Elizabeth A Morris, Constance D Lehman, Michael Garwood, Michael T Nelson, Douglas Yee, Sandra M Polin, Laura J Esserman, Constantine A Gatsonis, Gregory J Metzger, David C Newitt, Savannah C Partridge, Nola M Hylton
PURPOSE: To estimate the accuracy of predicting response to neoadjuvant chemotherapy (NACT) in patients with locally advanced breast cancer using MR spectroscopy (MRS) measurements made very early in treatment. MATERIALS AND METHODS: This prospective Health Insurance Portability and Accountability Act (HIPAA)-compliant protocol was approved by the American College of Radiology and local-site institutional review boards. One hundred nineteen women with invasive breast cancer of ≥3 cm undergoing NACT were enrolled between September 2007 and April 2010...
December 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27981485/-1-h-mr-spectroscopy-of-suspicious-breast-mass-lesions-at-3t-a-clinical-experience
#13
Stefania Montemezzi, Carlo Cavedon, Lucia Camera, Gabriele Meliadò, Francesca Caumo, Ilaria Baglio, Francesco Sardanelli
OBJECTIVES: To test 3T proton magnetic resonance spectroscopy ((1)H-MRS) for breast mass lesions. METHODS: Patients with BI-RADS 4-5 lesions at mammography/ultrasound were prospectively enrolled. After contrast-enhanced breast MRI, single-voxel MRS (point-resolved volume selection, PRESS); pencil-beam shimming; volume of interest 1 cm(3); TR/TE = 3000/135 ms) was performed. Spectra were considered reliable if the full width at half maximum (FWHM) of the water peak was ≤45 Hz...
December 15, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27977417/bioresponsive-polymer-coated-drug-nanorods-for-breast-cancer-treatment
#14
Tunyaboon Laemthong, Hannah H Kim, Kelly Dunlap, Caitlin Brocker, Dipak Barua, Daniel Forciniti, Yue-Wern Huang, Sutapa Barua
Ineffective drug release at the target site is among the top challenges for cancer treatment. This reflects the facts that interaction with the physiological condition can denature active ingredients of drugs, and low delivery to the disease microenvironment leads to poor therapeutic outcomes. We hypothesize that depositing a thin layer of bioresponsive polymer on the surface of drug nanoparticles would not only protect drugs from degradation but also allow the release of drugs at the target site. Here, we report a one-step process to prepare bioresponsive polymer coated drug nanorods (NRs) from liquid precursors using the solvent diffusion method...
January 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/27966730/a-novel-octa-nuclear-32-membered-zirconocene-macrocycle-based-on-the-aromatic-selenite
#15
Nian-Tao Yao, Ru-Fen Zhang, Shao-Liang Zhang, Qian-Li Li, Chun-Lin Ma
A novel macrocyclic zirconocene(iv) aromatic selenite [(CpZr)8L16]·2(Cp4Zr2(μ-O)Cl2) (complex 1) (Cp = cyclopentadienyl anion; L = 4-fluorobenzeneseleninic acid) was prepared by the reaction of bis(cyclopentadienyl)zirconium dichloride with 4-fluorobenzeneseleninic acid and characterized by elemental analysis, infrared spectroscopy, (1)H, (13)C NMR spectroscopy, ESI-MS, XRD and X-ray diffraction. The structure analysis shows that complex 1 is a centrosymmetric 32-membered macrocycle containing an eight-nuclear zirconocene...
January 3, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27959954/protein-bound-polysaccharide-from-corbicula-fluminea-inhibits-cell-growth-in-mcf-7-and-mda-mb-231-human-breast-cancer-cells
#16
Ningbo Liao, Jianjun Zhong, Ronghua Zhang, Xingqian Ye, Yanjun Zhang, Wenjun Wang, Yuexia Wang, Shiguo Chen, Donghong Liu, Ruihai Liu
A novel protein-bound polysaccharide, CFPS-1, isolated from Corbicula fluminea, is composed predominantly of mannose (Man) and glucose (Glc) in a molar ratio of 3.1:12.7. The polysaccharide, with an average molecular weight of about 283 kDa, also contains 10.8% protein. Atomic force microscopy, high-performance liquid chromatography, Fourier transform infrared spectroscopy, gas chromatography/mass spectrometry, and nuclear magnetic resonance spectroscopy analyses revealed that CFPS-1 has a backbone of 1,6-linked and 1,4,6-linked-α-D-Glc, which is terminated with a 1-linked-α-D-Man residue at the O-4 position of 1,4,6-linked-α-D-Glc, in a molar ratio of 3:1:1...
2016: PloS One
https://www.readbyqxmd.com/read/27939021/fabrication-and-evaluation-of-magnetic-activated-carbon-as-adsorbent-for-ultrasonic-assisted-magnetic-solid-phase-dispersive-extraction-of-bisphenol-a-from-milk-prior-to-high-performance-liquid-chromatographic-analysis-with-ultraviolet-detection
#17
Olga Filippou, Eleni A Deliyanni, Victoria F Samanidou
In the present study, the impregnation of a micro - meso porous activated carbon with magnetite (Fe3O4) was successfully achieved by sonication and the magnetic activated carbon prepared (Bmi) was evaluated as a new adsorbent for ultrasonic assisted magnetic solid phase dispersive extraction of Bisphenol A (BPA) from cow milk and human breast milk samples, prior to the determination by HPLC with UV detection. The prepared Bmi was characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM)...
January 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27934321/copper-ii-complexes-of-phenanthroline-and-histidine-containing-ligands-synthesis-characterization-and-evaluation-of-their-dna-cleavage-and-cytotoxic-activity
#18
Sílvia M G Leite, Luís M P Lima, Sofia Gama, Filipa Mendes, Maylis Orio, Isabel Bento, António Paulo, Rita Delgado, Olga Iranzo
Copper(II) complexes have been intensely investigated in a variety of diseases and pathological conditions due to their therapeutic potential. The development of these complexes requires a good knowledge of metal coordination chemistry and ligand design to control species distribution in solution and tailor the copper(II) centers in the right environment for the desired biological activity. Herein we present the synthesis and characterization of two ligands HL1 and H2L2 containing a phenanthroline unit (phen) attached to the amino group of histidine (His)...
November 21, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27933483/covalent-immobilization-of-human-placental-17%C3%AE-hydroxysteroid-dehydrogenase-type-1-onto-glutaraldehyde-activated-silica-coupled-with-lc-tof-ms-for-anti-cancer-drug-screening-applications
#19
Yin Bai, Wen-Di Zhou, Xian-Min Mu, Qian Zhang, Chen Yu, Bin Di, Meng-Xiang Su
Human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), a potential target in breast cancer prevention and therapy, was extracted from human placenta and immobilized on nonporous silica (∼5 μm) with a covalent method for the first time. The optimum initial enzyme concentration and immobilization time during the immobilization process were 0.42 mg mL(-1) and 12 h, repectively. The binding was confirmed by scanning electron microscope (SEM) and infrared spectroscopy (FT-IR). It could improve the pH, thermal and storage stability compared to free enzyme...
December 8, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27928952/in-vitro-anticancer-evaluation-of-platinum-ii-iv-complexes-with-diisoamyl-ester-of-s-s-ethylenediamine-n-n-di-2-propanoic-acid
#20
Bojana B Zmejkovski, Nebojša Pantelić, Lana Filipović, Sandra Aranđelović, Siniša Radulović, Tibor J Sabo, Goran N Kaluđerović
Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)2eddip}] (n = 2, 4: 1, 2, respectively; (S,S)-(i-Am)2eddip = O,O'-diisoamyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate) were synthesized and characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy and mass spectrometry. Quantum chemical calculations were used to predict formed isomers of 1 and 2. Furthermore, reduction of 2 with ascorbic acid was followed by time-dependant 13C NMR spectroscopy in order to enable assignation of the formed isomers for complex 1...
December 7, 2016: Anti-cancer Agents in Medicinal Chemistry
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