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Breast spectroscopy

Ali Shahvar, Roozbeh Soltani, Mohammad Saraji, Mohammad Dinari, Shekoufe Alijani
Herein, nano-sized covalent triazine-based framework grafted magnetic particles were synthesized by a facile Friedel-Crafts reaction between cyanuric chloride as node and biphenyl as linker. The formation of the material has been confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, field emission-scanning electron microscopy, thermogravimetric analysis, and N2 adsorption-desorption measurement. With respect to the material structure, the large number of aromatic rings in the molecular framework provided a bed for extracting aromatic ring-containing compounds through π-π stacking interactions...
June 16, 2018: Journal of Chromatography. A
Parvaneh Yazdani-Brojeni, Reo Tanoshima, Nobuko Taguchi, Facundo Garcia-Bournissen, Izhar Wallach, Myla E Moretti, Zulfikarali Verjee, Shinya Ito
BACKGROUND: Risk assessment of the use of quetiapine during breastfeeding is challenging owing to a paucity of data. METHODS: A pharmacokinetic study was conducted in lactating women who were taking quetiapine. The primary endpoint was to determine quetiapine concentration profiles in milk and estimated infant exposure levels. Multiple milk and a single blood quetiapine concentrations were determined using a highly sensitive liquid chromatography with tandem mass spectroscopy method...
June 14, 2018: Journal of Clinical Psychopharmacology
Zhichao Xiao, Yuting Luo, Guiying Wang, Changrong Ge, Guanghong Zhou, Wangang Zhang, Guozhou Liao
BACKGROUND: Boiled Wuding chicken was produced using whole chicken by washing, boiling 1 h with salt, deep frying and boiling 2 h. The effect of process on the WLOM (water-soluble lower molecule) profiles of products was characterized using proton nuclear magnetic resonance spectroscopy (1 H-NMR) and fatty acid composition of products was analyzed using gas chromatography-mass spectrometry (GC-MS). RESULTS: The metabonome was dominated by 49 WLOM and 22 fatty acid compounds were detected...
June 13, 2018: Journal of the Science of Food and Agriculture
Pham Duc Thinh, Bui Minh Ly, Roza V Usoltseva, Natalia M Shevchenko, Anton B Rasin, Stanislav D Anastyuk, Olesya S Malyarenko, Tatiana N Zvyagintseva, Pham Trung San, Svetlana P Ermakova
In the present study, three sulfated polysaccharides, two fractions of fucosylated chondroitin sulfates, and one sulfated fucan were isolated from the body wall of the Vietnamese sea cucumber Stichopus variegatus. The structure of the sulfated fucan fraction SvF3 from S. variegatus was investigated for the first time. According to NMR spectroscopy data, the sulfated fucan SvF3 contained 1,2- and 1,3-linked α-l-fucopyranose residues. Sulfate groups were found at the 2 and/or 4 positions. The structural analysis of fucoidan was assisted by tandem mass spectrometry; the recently-developed technique of autohydrolysis in heavy‑oxygen water for the obtaining of selectively labeled fucoidan fragments was applied...
June 6, 2018: International Journal of Biological Macromolecules
Randall L Barbour, Harry L Graber, San-Lian S Barbour
SUMMARY: In this report we introduce a weak-model approach for examination of the intrinsic time-varying properties of the hemoglobin signal, with the aim of advancing the application of functional near infrared spectroscopy (fNIRS) for the detection of breast cancer, among other potential uses. The developed methodology integrates concepts from stochastic network theory with known modulatory features of the vascular bed, and in doing so provides access to a previously unrecognized dense feature space that is shown to have promising diagnostic potential...
2018: PloS One
Ahmed Abdelfattah Hafez Abdellatif, Wael Abdellah Abdelhafez, Hatem Abdelmunsef Sarhan
Due to the unique optical properties like high brightness and narrow emission bands of Quantum dots, it is used as simple fluorescence materials in bio-imaging, immunoassays, microarrays, and other applications. To easy invistigate cell lines that overexpressed somtostatin receptors, somatostatin (SST) was conjugated with Quantum dots carrying PEG amine (Qdots-PEG-NH2 ). The conjugation of SST to Qdots-PEG-NH2 started with the thiolation of SST using Traut's reagent. Moreover, the Qdots-PEG-NH2 were subsequently activated by 500-fold molar excess of sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate (sulfo-SMCC) dissolved in phosphate buffer...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Hossein Danafar, Ali Sharafi, Shaghayegh Kheiri, Hamidreza Kheiri Manjili
Co-delivery approach has been recommended to reduce the amount of each drug and to achieve the synergistic effect for cancer treatment. Curcumin (CUR) and sulforaphane (SF) have antitumor effects, but their application is limited because of their low water solubility and poor oral bioavailability. To improve the bioavailability and solubility of SF and CUR, we performed an innovative co-delivery of them with PEGylated gold coated Fe3 O4 magnetic nanoparticles (PEGylated Fe3 O4 @Au NPs) to endorse SF and CUR maintenance as an effective and promising antitumor drugs...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Sina Dadgar, Joel Rodríguez Troncoso, Narasimhan Rajaram
Tumor hypoxia is a critical indicator of poor clinical outcome in patients with cancers of the breast, cervix, and oral cavity. The ability to noninvasively and reliably monitor tumor oxygenation both prior to and during therapy can aid in identifying poor treatment response earlier than is currently possible and lead to effective changes in treatment regimen. Diffuse reflectance spectroscopy (DRS) has been used in several studies to measure tissue scattering, total hemoglobin content (THb), and vascular oxygenation (sO2) in tissue...
June 2018: Journal of Biomedical Optics
Jun-Chau Chien, Ali Ameri, Erh-Chia Yeh, Alison N Killilea, Mekhail Anwar, Ali M Niknejad
This work presents a microfluidics-integrated label-free flow cytometry-on-a-CMOS platform for the characterization of the cytoplasm dielectric properties at microwave frequencies. Compared with MHz impedance cytometers, operating at GHz frequencies offers direct intracellular permittivity probing due to electric fields penetrating through the cellular membrane. To overcome the detection challenges at high frequencies, the spectrometer employs on-chip oscillator-based sensors, which embeds simultaneous frequency generation, electrode excitation, and signal detection capabilities...
June 6, 2018: Lab on a Chip
G A Nagana Gowda, Gregory A Barding, Jin Dai, Haiwei Gu, Daciana H Margineantu, David M Hockenbery, Daniel Raftery
The Warburg effect is a well-known phenomenon in cancer, but the glutamine addiction in which cancer cells utilize glutamine as an alternative source of energy is less well known. Recent efforts have focused on preventing cancer cell proliferation associated with glutamine addiction by targeting glutaminase using the inhibitor BPTES (bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide). In the current study, an investigation of the BPTES induced changes in metabolism was made in two human breast cancer cell lines, MCF7 (an estrogen receptor dependent cell line) and MDA-MB231 (a triple negative cell line), relative to the non-cancerous cell line, MCF10A...
2018: Frontiers in Molecular Biosciences
Yun Liu, Yu Qi, Chunyang Yin, Shunhao Wang, Shuping Zhang, An Xu, Wei Chen, Sijin Liu
Rationale: Graphene oxide (GO) has shown great promises in biomedical applications, such as drug delivery and thermotherapeutics, owing to its extraordinary physicochemical properties. Nonetheless, current biomedical applications of GO materials are premised on the basis of predesigned functions, and little consideration has been given to the influence of bio-transformation in the physiological environment on the physicochemical properties and predesigned functionalities of these materials. Hence, it is crucial to uncover the possible influence on GO's physicochemical properties and predesigned functionalities for better applications...
2018: Nanotheranostics
Qingbo Li, Wenjie Li, Jialin Zhang, Zhi Xu
As a molecular and noninvasive detection technology, Raman spectroscopy is promising for use in the early diagnosis of tumors. The SNR of spectra obtained from portable Raman spectrometers is low, which makes classification more difficult. A classification algorithm with a high recognition rate is required. In this paper, an algorithm of entropy weighted local-hyperplane k-nearest-neighbor (EWHK) is proposed for the identification of the spectra. When calculating the weighted distance between the prediction and the sample hyperplane, EWHK introduces the information entropy weighting to improve the algorithm of adaptive weighted k-local hyperplane (AWKH)...
June 4, 2018: Analyst
Harvey N Mayrovitz, Evelina Arzanova, Scarlett Somarriba, Samar Eisa
BACKGROUND: Early detection and tracking of breast cancer treatment-related lymphedema have been helped by quantitative assessment methods and parameters, including bioelectrical impedance spectroscopy and tissue dielectric constant (TDC). Such measurements are evaluated with respect to interarm differences or ratios that (when exceeding specified thresholds) are suggestive of lymphedema. Specific threshold ratios depend on the assessment method and have been reported for arms. However, there is far less information available on thresholds to assess lymphedema that manifests in at-risk hands and essentially nothing known about TDC ratios in healthy hands...
June 4, 2018: Lymphatic Research and Biology
Omid Fallahzadeh, Zohreh Dehghani-Bidgoli, Mohammad Assarian
Pathology as a common diagnostic test of cancer is an invasive, time-consuming, and partially subjective method. Therefore, optical techniques, especially Raman spectroscopy, have attracted the attention of cancer diagnosis researchers. However, as Raman spectra contain numerous peaks involved in molecular bounds of the sample, finding the best features related to cancerous changes can improve the accuracy of diagnosis in this method. The present research attempted to improve the power of Raman-based cancer diagnosis by finding the best Raman features using the ACO algorithm...
June 4, 2018: Lasers in Medical Science
Hamed Nosrati, Marziyeh Salehiabar, Manjili Hamidreza Kheiri, Soodabeh Davaran, Hossein Danafar
In this work we reported the synthesis of curcumin (CUR) loaded hydrophilic and hydrophobic natural amino acids (AAs) modified iron oxide magnetic nanoparticles (IONPs). Two types of AAs, L-lysine (Lys) and L-phenylalanine (PhA) were selected to study their effects on, loading capacity, release profile of CUR, biocompatibility and anticancer activity. CUR loaded amino acids modified iron oxide magnetic nanoparticles (F@AAs@CUR NPs) were characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM), and transmission electron microscopy (TEM) techniques...
May 31, 2018: Drug Development and Industrial Pharmacy
Irwin Cassells, Tameryn Stringer, Alan T Hutton, Sharon Prince, Gregory S Smith
A series of bidentate salicylaldimine ligands was prepared and reacted with either [RuCl(µ-Cl)(p-cymene)]2 , [RhCl(µ-Cl)(Cp*)]2 or [IrCl(µ-Cl)(Cp*)]2 . All of the compounds were characterised using an array of spectroscopic and analytical techniques, namely, nuclear magnetic resonance (NMR) spectroscopy, infrared (IR) spectroscopy and mass spectrometry. Single crystal X-ray diffraction (XRD) was used to confirm the bidentate coordination mode of the salicylaldimine ligand to the metal centre. The platinum group metal (PGM) complexes were screened against the MCF7 breast cancer cell line...
May 30, 2018: Journal of Biological Inorganic Chemistry: JBIC
Sorayya Behboodi, Fahimeh Baghbani-Arani, Sahar Abdalan, Seyed Ataollah Sadat Shandiz
The current experiment reveals the anticancer properties of silver nanoparticles (AgNPs) synthesized using aqueous leaf extract of Cichorium intybus, a significant medicinal plant. The characteristics of AgNPs were continuously studied by powder X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), zeta potential, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS) analysis. Current microscopic results show that produced AgNPs were spherical in shape with an average size of 17...
May 28, 2018: Biological Trace Element Research
Yingchun Zeng, Andy S K Cheng, Ting Song, Xiujie Sheng, Shaojing Wang, Jianfei Xie, Chetwyn C H Chan
BACKGROUND: Among women in China, gynecological cancers are the second most common cancers after breast cancer. Cancer-related cognitive impairment (CRCI) has emerged as a significant problem affecting gynecological cancer survivors. While acupuncture has been used in different aspects of cancer care, the possible positive effects of acupuncture on cognitive impairment have received little attention. This study hypothesized that patients would demonstrate lower neurocognitive performance and lower structural connectivity compared to healthy controls...
May 1, 2018: Integrative Cancer Therapies
Melina Yarbakht, Maryam Nikkhah, Ahmad Moshaii, Karina Weber, Christian Matthäus, Dana Cialla-May, Jürgen Popp
Nowadays, cancer is one of the most dangerous and deadly disease all around the world. Cancer that is diagnosed at early stages is more likely to be treated successfully. Treatment of progressed cancer is very difficult, and generally surviving rates are much lower. Therefore, much research has been focused on developing non-invasive methods for detection of cancer and monitoring of its progress. Within this contribution, we present a novel strategy for selective isolation and detection of breast cancer cell lines (MCF-7 and BT-20) based on surface enhanced Raman scattering (SERS)...
August 15, 2018: Talanta
Fay Nicolson, Lauren E Jamieson, Samuel Mabbott, Konstantinos Plakas, Neil C Shand, Michael R Detty, Duncan Graham, Karen Faulds
In order to improve patient survival and reduce the amount of unnecessary and traumatic biopsies, non-invasive detection of cancerous tumours is of imperative and urgent need. Multicellular tumour spheroids (MTS) can be used as an ex vivo cancer tumour model, to model in vivo nanoparticle (NP) uptake by the enhanced permeability and retention (EPR) effect. Surface enhanced spatially offset Raman spectroscopy (SESORS) combines both surface enhanced Raman spectroscopy (SERS) and spatially offset Raman spectroscopy (SORS) to yield enhanced Raman signals at much greater sub-surface levels...
April 21, 2018: Chemical Science
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