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Breast spectroscopy

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https://www.readbyqxmd.com/read/28812373/evaluation-of-factors-in-development-of-vis-nir-spectroscopy-models-for-discriminating-pse-dfd-and-normal-broiler-breast-meat
#1
Hongzhe Jiang, Seung-Chul Yoon, Hong Zhuang, Wei Wang, Yi Yang
1. To evaluate the performance of visible and near-infrared (Vis/NIR) spectroscopic models for discriminating true pale, soft and exudative (PSE), normal and dark, firm and dry (DFD) broiler breast meat in different conditions of preprocessing methods, spectral ranges, characteristic wavelengths selection and water-holding capacity (WHC) indexes. 2. Quality attributes of 214 intact chicken fillets (pectoralis major), such as lightness (L*), pH, and WHC indicators including drip loss (DL), water gain (WG), and expressible fluid (EF) were measured...
August 16, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28810632/a-novel-antitumor-compound-nobiliside-d-isolated-from-sea-cucumber-holothuria-nobilis-selenka
#2
Jia-Jia Zhang, Ke-Qi Zhu
An anticancer compound, triterpene glycoside, was isolated from Holothuria nobilis Selenka. Its chemical structure and configuration were determined by two-dimensional nuclear magnetic resonance spectroscopy and electrospray ionization mass spectrometry. The novel active compound was identified as nobiliside D, with the molecular formula C40H61O17SNa and chemical name 3-O-[-β-D-pyranosyl (1-2)-4'-O-sulfon-ate-β-D-xylopyranosyl]-alkoxy-9-ene-3β, 12α, 17α, 25β-4 alcohol. An antitumor test was performed using xCELLigence Real-Time Cell Analysis...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28802177/dna-biosensors-based-on-gold-nanoparticles-modified-graphene-oxide-for-the-detection-of-breast-cancer-biomarkers-for-early-diagnosis
#3
Ayman Ali Saeed, Josep Lluís Acero Sánchez, Ciara K O'Sullivan, Mohammed Nooredeen Abbas
Two different DNA (ERBB2c and CD24c) modified gold nanoparticles and graphene oxide loaded on glassy carbon electrodes were prepared for early detection of breast cancer markers by electrochemical detection of HER2. Comparative study of ERBB2c and CD24c for the detection was carried out. A "sandwich-type" detection strategy was employed in this electrochemical DNA biosensor and its response was measured by amperometric detection. The electrochemical signal enhancement achieved via gold nanoparticles and grapheme oxide system allowed for sensitive detection of the breast cancer biomarker ERBB2 and the control marker CD24...
July 14, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28774804/an-innovative-mediator-free-immunosensor-for-detection-of-tumor-suppressor-protein-p53-in-unprocessed-human-plasma-and-cancer-cell-lysates
#4
Mohammad Hasanzadeh, Hosein Navayebagban, Ahad Mokhtarzadeh, Nasrin Shadjou, Soltanali Mahboob
An innovative mediator-free electrochemical immunosensor for quantitation of p53 tumor suppressor protein based on signal amplification strategy was fabricated. In this work, biotin conjugated p53-antibody (anti-p53) was immobilized onto a green and biocompatible nanocomposite containing poly L-cysteine (P-Cys) as conductive matrix and 3D gold nanoparticles (GNPs) as signal amplification element. Therefore, a novel nanocomposite film based on P-Cys and GNPs was exploited to develop a highly sensitive immunosensor for detection of p53 protein...
July 31, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28773799/chemical-and-structural-characterization-of-several-mid-term-explanted-breast-prostheses
#5
Angela Amoresano, Luca De Stefano, Ilaria Rea, Federica Pane, Leila Birolo, Fabrizio Schonauer
The recent scandal of poly implant prostheses (PIP), which were found in some cases to be made of non-medical grade silicone (as reported by the European Scientific Committee on Emerging and Newly Identified Health Risks), had a great social impact. Thousands of patients asked for implant removal with significant costs for public health care systems. We analysed, by a multidisciplinary approach, sixteen different breast implants after explantation by using several analytical and structural techniques, such as Fourier Transform infrared spectroscopy (FT-IR), mass spectrometry equipped by ion coupled plasma (ICP-MS), gas-chromatography (GC-MS), and tensile testing...
August 9, 2016: Materials
https://www.readbyqxmd.com/read/28765645/structure-of-the-c-terminal-domain-of-tradd-reveals-a-novel-fold-in-the-death-domain-superfamily
#6
Ning Zhang, Wensu Yuan, Jing-Song Fan, Zhi Lin
The TNFR1-associated death domain protein (TRADD) is an intracellular adaptor protein involved in various signaling pathways, such as antiapoptosis. Its C-terminal death domain (DD) is responsible for binding other DD-containing proteins including the p75 neurotrophin receptor (p75(NTR)). Here we present a solution structure of TRADD DD derived from high-resolution NMR spectroscopy. The TRADD DD comprises two super-secondary structures, an all-helix Greek key motif and a β-hairpin motif flanked by two α helices, which make it unique among all known DD structures...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28763967/a-feasibility-quantification-study-of-total-volatile-basic-nitrogen-tvb-n-content-in-duck-meat-for-freshness-evaluation
#7
Lu Qiao, Xiuying Tang, Jun Dong
Total volatile basic nitrogen (TVB-N) content is one of the core indicators for evaluating freshness of duck meat. Visible and near-infrared (Vis/NIR) reflectance spectroscopy was implemented in this study to determine the TVB-N content in duck breast meat. Quantitative calibration models were built by partial least square regression (PLSR) between the spectral data and the measured TVB-N values. The different spectral pre-processing methods were employed and synergy interval partial least squares and principal component analysis methods were used to select important wavelengths...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28756174/the-potent-anti-cancer-activity-of-dioclea-lasiocarpa-lectin
#8
Ana C S Gondim, Isolda Romero-Canelón, Eduardo H S Sousa, Claudia A Blindauer, Jennifer S Butler, María J Romero, Carlos Sanchez-Cano, Bruno L Sousa, Renata P Chaves, Celso S Nagano, Benildo S Cavada, Peter J Sadler
The lectin DLasiL was isolated from seeds of the Dioclea lasiocarpa collected from the northeast coast of Brazil and characterized for the first time by mass spectrometry, DNA sequencing, inductively coupled plasma-mass spectrometry, electron paramagnetic resonance, and fluorescence spectroscopy. The structure of DLasiL lectin obtained by homology modelling suggested strong conservation of the dinuclear Ca/Mn and sugar-binding sites, and dependence of the solvent accessibility of tryptophan-88 on the oligomerisation state of the protein...
July 16, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28755573/heteroleptic-oxidovanadium-iv-complexes-of-2-hydroxynaphtylaldimine-and-polypyridyl-ligands-against-trypanosoma-cruzi-and-prostate-cancer-cells
#9
Gonzalo Scalese, M Florencia Mosquillo, Santiago Rostán, Jorge Castiglioni, Irina Alho, Leticia Pérez, Isabel Correia, Fernanda Marques, João Costa Pessoa, Dinorah Gambino
In Latin America Chagas disease is an endemic illness caused by the parasite Trypanosoma cruzi (T. cruzi), killing more people than any other parasitic disease. Current chemotherapies are old and inadequate, thus the development of efficient ones is urgently needed. Vanadium-based complexes have been shown to be a promising approach both against parasitic diseases and cancer and this study aims to achieve significant advances in the pursue of effective compounds. Heteroleptic vanadium complexes of Schiff bases and polypyridine compounds were prepared and their stability in solution evaluated by EPR (Electronic Paramagnetic Resonance) and NMR spectroscopy...
July 18, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28755557/amphiphilic-gemini-pyridinium-mediated-incorporation-of-zn-ii-meso-tetrakis-4-carboxyphenyl-porphyrin-into-water-soluble-gold-nanoparticles-for-photodynamic-therapy
#10
María E Alea-Reyes, Jorge Soriano, Inma Mora-Espí, Mafalda Rodrigues, David A Russell, Leonardo Barrios, Lluïsa Pérez-García
Zn-containing porphyrins are intensely investigated for their ability to form reactive oxygen species and thereby being potent photosensitizers for use in photodynamic therapy (PDT). Some of the drawbacks of the PDT approach, such as unspecific distribution, could be addressed by means of photosensitizer drug delivery systems. In this work, we synthesize and characterize new water-soluble gold nanoparticles (GNP) stabilized by a mixture of a polyethyleneglycol-containing thiol (to improve water solubility) and a new amphiphilic gemini-type pyridinium salt, which also acts as promotor of the incorporation of the anionic photosensitizer Na-ZnTCPP into the GNP...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28742387/vitamin-d-loaded-nanostructured-lipid-carrier-nlc-a-new-strategy-for-enhancing-efficacy-of-doxorubicin-in-breast-cancer-treatment
#11
Mehdi Sabzichi, Jamal Mohammadian, Maryam Mohammadi, Farhad Jahanfar, Ali Akbar Movassagh Pour, Hamed Hamishehkar, Alireza Ostad-Rahimi
The dangerous dose-dependent side effects of anticancer agents triggered the finding of new approaches for elevated chemotherapy efficacy. This study investigated the potential application of nanostructured lipid careers (NLCs) in increasing vitamin D3 (VitD) effectiveness in breast cancer cell (MCF-7) in concurrent administration with doxorubicin (Dox). VitD-loaded NLCs were characterized by particle size, zeta potential, Fourier transform infrared spectroscopy, and scanning electron microscope. Cytotoxicity and molecular effects of formulation were evaluated by MTT, DAPI staining, flow cytometry, and real-time quantitative PCR assays...
July 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28738425/preparation-and-characterization-of-pegylated-iron-oxide-gold-nanoparticles-for-delivery-of-sulforaphane-and-curcumin
#12
Hossein Danafar, Ali Sharafi, Sonia Askarlou, Hamidreza Kheiri Manjili
Natural products have been used for the treatment of various diseases such as cancer. Curcumin (CUR) and sulforaphane (SF) have anti-cancer effects, but their application is restricted because of their low water solubility and poor oral bioavailability. To improve the bioavailability and solubility of SF and CUR, we performed an advanced delivery of SF and CUR with PEGylated gold coated Fe3O4 magnetic nanoparticles (PEGylated Fe3O4@Au NPs) to endorse SF and CUR maintenance as an effective and promising antitumor drugs...
July 24, 2017: Drug Research
https://www.readbyqxmd.com/read/28734141/new-dinuclear-palladium-ii-complexes-studies-of-the-nucleophilic-substitution-reactions-dna-bsa-interactions-and-cytotoxic-activity
#13
Dušan Ćoćić, Snežana Jovanović, Marija Nišavić, Dejan Baskić, Danijela Todorović, Suzana Popović, Živadin D Bugarčić, Biljana Petrović
Six new dinuclear Pd(II) complexes, [{Pd(2,2'-bipy)Cl}2(μ-pz)](ClO4)2 (Pd1), [{Pd(dach)Cl}2(μ-pz)](ClO4)2 (Pd2), [{Pd(en)Cl}2(μ-pz)](ClO4)2 (Pd3), [{Pd(2,2'-bipy)Cl}2(μ-4,4'-bipy)](ClO4)2 (Pd4), [{Pd(dach)Cl}2(μ-4,4'-bipy)](ClO4)2 (Pd5) and [{Pd(en)Cl}2(μ-4,4'-bipy)](ClO4)2 (Pd6) (where 2,2'-bipy=2,2'-bipyridyl, pz=pyrazine, dach=trans-(±)-1,2-diaminocyclohexane, en=ethylenediamine, 4,4'-bipy=4,4'-bipyridyl) have been synthesized and characterized by elemental microanalysis, IR, (1)H NMR and MALDI-TOF mass spectrometry...
July 16, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28730725/targeting-nano-drug-delivery-to-cancer-cells-using-tunable-multi-layer-silver-decorated-gold-nanorods
#14
Zeid A Nima, Ahmed M Alwbari, Vijayalakshmi Dantuluri, Rabab N Hamzah, Natasha Sra, Pooja Motwani, Konstantinos Arnaoutakis, Rebecca A Levy, Amani F Bohliqa, Dmitry Nedosekin, Vladimir P Zharov, Issam Makhoul, Alexandru S Biris
Multifunctional nanoparticles have high potential as targeting delivery vehicles for cancer chemotherapy. In this study, silver-decorated gold nanorods (AuNR\Ag) have been successfully used to deliver specific, targeted chemotherapy against breast cancer (MCF7) and prostate carcinoma (PC3) cell lines. Doxorubicin, a commonly used chemotherapy, and anti-Epithelial cell adhesion molecule (anti-EpCAM) antibodies were covalently bonded to thiolated polyethylene glycol-coated AuNR\Ag, and the resultant system was used to deliver the drugs to cancer cells in vitro...
July 21, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28721737/a-new-water-soluble-nanomicelle-formed-through-self-assembly-of-pectin-curcumin-conjugates-preparation-characterization-and-anticancer-activity-evaluation
#15
Feng Bai, Jiajing Diao, Ying Wang, Shixin Sun, Hongmei Zhang, Yunyun Liu, Yanqing Wang, Jian Cao
Curcumin is a dominating active component of Curcuma longa and has been studied widely because of its prominent biological activities. The extremely low aqueous solubility, stability, and bioavailability of curcumin limit its application in the field of medicine. In this study, we developed pectin-curcumin (PEC-CCM) conjugates that could self-assemble water-soluble nanomicelles in aqueous solution. The structure of PEC-CCM conjugates was characterized by ultraviolet-visible spectra, fluorescence spectra, Fourier transform infrared spectroscopy, and (1)H nuclear magnetic resonance spectroscopy...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28719146/natural-compounds-in-cancer-prevention-effects-of-coffee-extracts-and-their-main-polyphenolic-component-5-cqa-on-oncogenic-ras-proteins
#16
Alessandro Palmioli, Carlotta Cairamelli, Renata Tisi, Michela Spinelli, Gaia De Sanctis, Elena Sacco, Cristina Airoldi
Recent epidemiological studies demonstrate that consumption of healthy foods, especially rich in polyphenols content, might reduce the incidence of cancer and degenerative diseases. In particular, chlorogenic acids (CGAs) occur ubiquitously in food, representing the most abundant polyphenols in the human diet. A number of CGA beneficial biological effects, including anti-inflammatory activity, anti-carcinogenic activity and protection against neurodegenerative diseases have been reported. However, the molecular mechanisms at the basis of these biological activities have not yet been investigated in depth...
July 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28711937/magnetic-resonance-metabolic-profiling-of-estrogen-receptor-positive-breast-cancer-correlation-with-currently-used-molecular-markers
#17
Ji Soo Choi, Dahye Yoon, Ja Seung Koo, Siwon Kim, Vivian Youngjean Park, Eun-Kyung Kim, Suhkmann Kim, Min Jung Kim
Estrogen receptor (ER)-positive breast cancers overall have a good prognosis, however, some patients suffer relapses and do not respond to endocrine therapy. The purpose of this study was to determine whether there are any correlations between high-resolution magic angle spinning (HR-MAS) magnetic resonance spectroscopy (MRS) metabolic profiles of core needle biopsy (CNB) specimens and the molecular markers currently used in patients with ER-positive breast cancers. The metabolic profiling of CNB samples from 62 ER-positive cancers was performed by HR-MAS MRS...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28708720/predicting-neoadjuvant-chemotherapy-in-nonconcentric-shrinkage-pattern-of-breast-cancer-using-1h-magnetic-resonance-spectroscopic-imaging
#18
Juan Zhou, Peng-Gang Qiao, Hong-Tao Zhang, Gong-Jie Li, Ze-Fei Jiang
OBJECTIVE: The aim of this study was to explore the response to neoadjuvant chemotherapy (NAC) in nonconcentric shrinkage pattern of breast cancer (BC) patients using H-magnetic resonance spectroscopy. METHODS: Twenty-five BC patients were the study cohort. All patients received AT-based regimen as first-line treatment. Tumor response to chemotherapy was evaluated after the second and fourth cycles using magnetic resonance imaging and magnetic resonance spectroscopy...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28702618/copper-ii-complexes-of-functionalized-2-2-6-2-terpyridines-and-2-6-di-thiazol-2-yl-pyridine-structure-spectroscopy-cytotoxicity-and-catalytic-activity
#19
Katarzyna Czerwińska, Barbara Machura, Slawomir Kula, Stanisław Krompiec, Karol Erfurt, Catarina Roma-Rodrigues, Alexandra R Fernandes, Lidia S Shul'pina, Nikolay S Ikonnikov, Georgiy B Shul'pin
Six new copper(ii) complexes with 2,2':6',2''-terpyridine (4'-R(n)-terpy) [1 (R(1) = furan-2-yl), 2 (R(2) = thiophen-2-yl), and 3 (R(3) = 1-methyl-1H-pyrrol-2-yl)] and 2,6-di(thiazol-2-yl)pyridine derivatives (R(n)-dtpy) [4 (R(1)), 5 (R(2)), and 6 (R(3))] have been synthesized by a reaction between copper(ii) chloride and the corresponding ligand. The complexes have been characterized by UV-vis and IR spectroscopy, and their structures have been determined by X-ray analysis. The antiproliferative potential of copper(ii) complexes of 2,2':6',2''-terpyridine and 2,6-di(thiazol-2-yl)pyridine derivatives towards human colorectal (HCT116) and ovarian (A2780) carcinoma as well as towards lung (A549) and breast adenocarcinoma (MCF7) cell lines was examined...
July 25, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28700982/phosphatidylcholine-specific-phospholipase-c-inhibition-reduces-her2-overexpression-cell-proliferation-and-in-vivo-tumor-growth-in-a-highly-tumorigenic-ovarian-cancer-model
#20
Luisa Paris, Franca Podo, Francesca Spadaro, Laura Abalsamo, Maria Elena Pisanu, Alessandro Ricci, Serena Cecchetti, Luisa Altabella, Maria Buoncervello, Ludmila Lozneanu, Marina Bagnoli, Carlo Ramoni, Silvana Canevari, Delia Mezzanzanica, Egidio Iorio, Rossella Canese
Antagonizing the oncogenic effects of human epidermal growth factor receptor 2 (HER2) with current anti-HER2 agents has not yet yielded major progress in the treatment of advanced HER2-positive epithelial ovarian cancer (EOC). Using preclinical models to explore alternative molecular mechanisms affecting HER2 overexpression and oncogenicity may lead to new strategies for EOC patient treatment. We previously reported that phosphatidylcholine-specific phospholipase C (PC-PLC) exerts a pivotal role in regulating HER2 overexpression in breast cancer cells...
July 5, 2017: Oncotarget
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