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Breast biomechanics

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https://www.readbyqxmd.com/read/28614671/gestalt-breastfeeding-helping-mothers-and-infants-optimize-positional-stability-and-intraoral-breast-tissue-volume-for-effective-pain-free-milk-transfer
#1
Pamela Douglas, Renee Keogh
In the past decade, biological nurturing and activation of maternal and infant instincts after birth have constituted a major advance in clinical breastfeeding support. Yet, physiologic breastfeeding initiation is not enough to ensure ongoing pain-free and effective breastfeeding for many pairs. Current interventions, including "hands-off" mammalian approaches, do not improve breastfeeding outcomes, including in randomized controlled trials. Back-arching, difficulty latching or staying on the breast, and fussing at the breast are common signs of infant positional instability during breastfeeding...
June 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28520556/breast-tissue-stiffness-estimation-for-surgical-guidance-using-gravity-induced-excitation
#2
Rebekah H Griesenauer, Jared A Weis, Lori R Arlinghaus, Ingrid M Meszoely, Michael I Miga
Tissue stiffness interrogation is fundamental in breast cancer diagnosis and treatment. Furthermore, biomechanical models for predicting breast deformations have been created for several breast cancer applications. Within these applications, constitutive mechanical properties must be defined and the accuracy of this estimation directly impacts the overall performance of the model. In this study, we present an image-derived computational framework to obtain quantitative, patient specific stiffness properties for application in image-guided breast cancer surgery and interventions...
May 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28428257/the-size-speed-force-relationship-governs-migratory-cell-response-to-tumorigenic-factors
#3
Aldo Leal-Egaña, Gaelle Letort, Jean-Louis Martiel, Andreas Christ, Timothée Vignaud, Caroline Roelants, Odile Filhol, Manuel Théry
Tumor development progresses through a complex path of biomechanical changes leading first to cell growth and contraction and then cell deadhesion, scattering, and invasion. Tumorigenic factors may act specifically on one of these steps or have a wider spectrum of actions, leading to a variety of effects and thus sometimes to apparent contradictory outcomes. Here we used micropatterned lines of collagen type I/fibronectin on deformable surfaces to standardize cell behavior and measure simultaneously cell size, speed of motion and magnitude of the associated traction forces at the level of a single cell...
June 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28270967/normalization-of-compression-induced-hemodynamics-in-patients-responding-to-neoadjuvant-chemotherapy-monitored-by-dynamic-tomographic-optical-breast-imaging-dtobi
#4
Amir Y Sajjadi, Steven J Isakoff, Bin Deng, Bhawana Singh, Christy M Wanyo, Qianqian Fang, Michelle C Specht, Lidia Schapira, Beverly Moy, Aditya Bardia, David A Boas, Stefan A Carp
We characterize novel breast cancer imaging biomarkers for monitoring neoadjuvant chemotherapy (NACT) and predicting outcome. Specifically, we recruited 30 patients for a pilot study in which NACT patients were imaged using dynamic tomographic optical breast imaging (DTOBI) to quantify the hemodynamic changes due to partial mammographic compression. DTOBI scans were obtained pre-treatment (referred to as day 0), as well as 7 and 30 days into therapy on female patients undergoing NACT. We present data for the 13 patients who participated in both day 0 and 7 measurements and had evaluable data, of which 7 also returned for day 30 measurements...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28228783/-atypical-atypical-femur-fractures-and-use-of-bisphosphonates
#5
Denise M van de Laarschot, Matthijs P Somford, Agnes Jager, Edwin H Oei, P Koen Bos, M Carola Zillikens
BACKGROUND: Atypical femur fractures (AFFs) present a rare but serious condition associated with use of bisphosphonates. Underlying mechanisms and clinical risk factors remain unclear. According to the diagnostic criteria formulated by the ASBMR, a lateral localization of an AFF is required. CASE HISTORY: We present a patient who developed bilateral leg pain while using an oral bisphosphonate and aromatase inhibitor in the course of adjuvant treatment for breast cancer...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28042181/three-dimensional-image-based-mechanical-modeling-for-predicting-the-response-of-breast-cancer-to-neoadjuvant-therapy
#6
Jared A Weis, Michael I Miga, Thomas E Yankeelov
The use of quantitative medical imaging data to initialize and constrain mechanistic mathematical models of tumor growth has demonstrated a compelling strategy for predicting therapeutic response. More specifically, we have demonstrated a data-driven framework for prediction of residual tumor burden following neoadjuvant therapy in breast cancer that uses a biophysical mathematical model combining reaction-diffusion growth/therapy dynamics and biomechanical effects driven by early time point imaging data. Whereas early work had been based on a limited dimensionality reduction (two-dimensional planar modeling analysis) to simplify the numerical implementation, in this work, we extend our framework to a fully volumetric, three-dimensional biophysical mathematical modeling approach in which parameter estimates are generated by an inverse problem based on the adjoint state method for numerical efficiency...
February 1, 2017: Computer Methods in Applied Mechanics and Engineering
https://www.readbyqxmd.com/read/27893988/withdrawn-endothelin-signaling-in-bone
#7
Jasmin Kristianto, Michael G Johnson, Rafia Afzal, Robert D Blank
No abstract text is available yet for this article.
November 11, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27887657/complexity-galore-3d-cultures-biomechanics-and-systems-medicine-at-the-eighth-enbdc-workshop-methods-in-mammary-gland-development-and-cancer
#8
Bethan Lloyd-Lewis, Anoeska A A van de Moosdijk, Mohamed Bentires-Alj, Robert B Clarke, Renée van Amerongen
The ENBDC workshop "Methods in Mammary Gland Development and Cancer" is an established international forum to showcase the latest technical advances in the field. The eighth meeting focused on emerging concepts and technologies for studying normal and neoplastic breast development.
November 25, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27847941/atomic-force-microscopy-and-graph-analysis-to-study-the-p-cadherin-sfk-mechanotransduction-signalling-in-breast-cancer-cells
#9
A S Ribeiro, F A Carvalho, J Figueiredo, R Carvalho, T Mestre, J Monteiro, A F Guedes, M Fonseca, J Sanches, R Seruca, N C Santos, J Paredes
Physical forces mediated by cell-cell adhesion molecules, as cadherins, play a crucial role in preserving normal tissue architecture. Accordingly, altered cadherins' expression has been documented as a common event during cancer progression. However, in most studies, no data exist linking pro-tumorigenic signaling and variations in the mechanical balance mediated by adhesive forces. In breast cancer, P-cadherin overexpression increases in vivo tumorigenic ability, as well as in vitro cell invasion, by activating Src family kinase (SFK) signalling...
November 16, 2016: Nanoscale
https://www.readbyqxmd.com/read/27825052/identification-of-potential-compensatory-muscle-strategies-in-a-breast-cancer-survivor-population-a-combined-computational-and-experimental-approach
#10
Jaclyn N Chopp-Hurley, Rebecca L Brookham, Clark R Dickerson
BACKGROUND: Biomechanical models are often used to estimate the muscular demands of various activities. However, specific muscle dysfunctions typical of unique clinical populations are rarely considered. Due to iatrogenic tissue damage, pectoralis major capability is markedly reduced in breast cancer population survivors, which could influence arm internal and external rotation muscular strategies. METHODS: Accordingly, an optimization-based muscle force prediction model was systematically modified to emulate breast cancer population survivors through adjusting pectoralis capability and enforcing an empirical muscular co-activation relationship...
October 29, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27778131/the-role-of-heparins-and-nano-heparins-as-therapeutic-tool-in-breast-cancer
#11
REVIEW
Nikos A Afratis, Konstantina Karamanou, Zoi Piperigkou, Demitrios H Vynios, Achilleas D Theocharis
Glycosaminoglycans are integral part of the dynamic extracellular matrix (ECM) network that control crucial biochemical and biomechanical signals required for tissue morphogenesis, differentiation, homeostasis and cancer development. Breast cancer cells communicate with stromal ones to modulate ECM mainly through release of soluble effectors during cancer progression. The intracellular cross-talk between cell surface receptors and estrogen receptors is important for the regulation of breast cancer cell properties and production of ECM molecules...
June 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27570694/non-contact-single-shot-elastography-using-line-field-low-coherence-holography
#12
Chih-Hao Liu, Alexander Schill, Chen Wu, Manmohan Singh, Kirill V Larin
Optical elastic wave imaging is a powerful technique that can quantify local biomechanical properties of tissues. However, typically long acquisition times make this technique unfeasible for clinical use. Here, we demonstrate non-contact single shot elastographic holography using a line-field interferometer integrated with an air-pulse delivery system. The propagation of the air-pulse induced elastic wave was imaged in real time, and required a single excitation for a line-scan measurement. Results on tissue-mimicking phantoms and chicken breast muscle demonstrated the feasibility of this technique for accurate assessment of tissue biomechanical properties with an acquisition time of a few milliseconds using parallel acquisition...
August 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27536488/multidisciplinary-oncoplastic-approach-reduces-infection-in-chest-wall-resection-and-reconstruction-for-malignant-chest-wall-tumors
#13
Haitham H Khalil, Marco N Malahias, Balapathiran Balasubramanian, Madava G Djearaman, Babu Naidu, Melvin F Grainger, Maninder Kalkat
BACKGROUND: Management of complex thoracic defects post tumor extipiration is challenging because of the nature of pathology, the radical approach, and the insertion of prosthetic material required for biomechanical stability. Wound complications pose a significant problem that can have detrimental effect on patient outcome. The authors outline an institutional experience of a multidisciplinary thoracic oncoplastic approach to improve outcomes. METHODS: Prospectively collected data from 71 consecutive patients treated with chest wall resection and reconstruction were analyzed (2009-2015)...
July 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27508316/stealthy-role-of-size-driven-stresses-in-biomechanics-of-breast-implants-capsular-contracture
#14
Massimiliano Fraldi, Luca Esposito, Arsenio Cutolo, Angelo Rosario Carotenuto, Ciro Adamo, Guido Molea
Breast Capsular Contracture (BCC) is one of the adverse complications occurring with greater incidence in breast augmentation surgical procedures. Its formation can be interpreted as the conclusive result of the physiological process known as response to a foreign body. From a biochemical standpoint, the formation of the peri-prosthetic capsule is certainly a multifactorial process: many hypotheses concerning its etiology have been suggested in the literature and a number of related pharmacological protocols have been consequently proposed to clinically treat this pathology with the aim to prevent further complications and avoid future re-interventions...
December 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27501296/deciphering-cell-to-cell-communication-in-acquisition-of-cancer-traits-extracellular-membrane-vesicles-are-regulators-of-tissue-biomechanics
#15
Deep Pokharel, Philip Wijesinghe, Vici Oenarto, Jamie F Lu, David D Sampson, Brendan F Kennedy, Vincent P Wallace, Mary Bebawy
Deciphering the role of cell-to-cell communication in acquisition of cancer traits such as metastasis is one of the key challenges of integrative biology and clinical oncology. In this context, extracellular vesicles (EVs) are important vectors in cell-to-cell communication and serve as conduits in the transfer of cellular constituents required for cell function and for the establishment of cellular phenotypes. In the case of malignancy, they have been shown to support the acquisition of common traits defined as constituting the hallmarks of cancer...
August 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27467184/do-women-with-smaller-breasts-perform-better-in-long-distance-running
#16
Nicola Brown, Joanna Scurr
Literature has established that a range of physiological, biomechanical, and training variables influence marathon performance. The influence of anthropometric characteristics has also received attention. However, despite major marathons exceeding 40,000 participants and approximately a third of these runners being female, no data exist on the influence of the breast on running performance. This cross-sectional study aimed to explore the impact of breast mass on marathon finish time. One hundred and sixty-eight of 321 female marathon runners contacted completed an on-line survey focusing on marathon performance during the 2012 London marathon...
November 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/27464479/angiomotin-like-1-is-a-novel-component-of-the-n-cadherin-complex-affecting-endothelial-pericyte-interaction-in-normal-and-tumor-angiogenesis
#17
Yujuan Zheng, Yuanyuan Zhang, Giuseppina Barutello, Kungchun Chiu, Maddalena Arigoni, Costanza Giampietro, Federica Cavallo, Lars Holmgren
Transmission of mechanical force via cell junctions is an important component that molds cells into shapes consistent with proper organ function. Of particular interest are the cadherin transmembrane proteins, which play an essential role in connecting cell junctions to the intra-cellular cytoskeleton. Understanding how these biomechanical complexes orchestrate intrinsic and extrinsic forces is important for our understanding of the underlying mechanisms driving morphogenesis. We have previously identified the Amot protein family, which are scaffold proteins that integrate polarity, junctional, and cytoskeletal cues to modulate cellular shape in endothelial as well as epithelial cells...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27423464/combined-treatment-with-a-transforming-growth-factor-beta-inhibitor-1d11-and-bortezomib-improves-bone-architecture-in-a-mouse-model-of-myeloma-induced-bone-disease
#18
Jeffry S Nyman, Alyssa R Merkel, Sasidhar Uppuganti, Bijaya Nayak, Barbara Rowland, Alexander J Makowski, Babatunde O Oyajobi, Julie A Sterling
Multiple myeloma (MM) patients frequently develop tumor-induced bone destruction, yet no therapy completely eliminates the tumor or fully reverses bone loss. Transforming growth factor-β (TGF-β) activity often contributes to tumor-induced bone disease, and pre-clinical studies have indicated that TGF-β inhibition improves bone volume and reduces tumor growth in bone metastatic breast cancer. We hypothesized that inhibition of TGF-β signaling also reduces tumor growth, increases bone volume, and improves vertebral body strength in MM-bearing mice...
October 2016: Bone
https://www.readbyqxmd.com/read/27304456/three-dimensional-reflectance-traction-microscopy
#19
Jihan Kim, Christopher A R Jones, Nicholas Scott Groves, Bo Sun
Cells in three-dimensional (3D) environments exhibit very different biochemical and biophysical phenotypes compared to the behavior of cells in two-dimensional (2D) environments. As an important biomechanical measurement, 2D traction force microscopy can not be directly extended into 3D cases. In order to quantitatively characterize the contraction field, we have developed 3D reflectance traction microscopy which combines confocal reflection imaging and partial volume correlation postprocessing. We have measured the deformation field of collagen gel under controlled mechanical stress...
2016: PloS One
https://www.readbyqxmd.com/read/27291899/understanding-key-performance-indicators-for-breast-support-an-analysis-of-breast-support-effects-on-biomechanical-physiological-and-subjective-measures-during-running
#20
Debbie Risius, Alexandra Milligan, Jason Berns, Nicola Brown, Joanna Scurr
To assess the effectiveness of breast support previous studies monitored breast kinematics and kinetics, subjective feedback, muscle activity (EMG), ground reaction forces (GRFs) and physiological measures in isolation. Comparing these variables within one study will establish the key performance variables that distinguish between breast supports during activities such as running. This study investigates the effects of changes in breast support on biomechanical, physiological and subjective measures during running...
May 2017: Journal of Sports Sciences
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