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Breast biomechanics

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https://www.readbyqxmd.com/read/29162703/deformability-of-breast-cancer-cells-in-correlation-with-surface-markers-and-cell-rolling
#1
Amina Mohammadalipour, Monica M Burdick, David F J Tees
Although the cancer stem cell (CSC) hypothesis has been around for many years, the reliability of cell-surface markers to classify CSCs has remained debatable. The finding that cancerous cells are significantly more deformable than healthy ones has provided motivation to consider mechanical properties as a possible biomarker for stemness. In this study, using the micropipette aspiration technique, mechanical properties of multiple breast cancer cell lines were investigated and correlated with breast cancer stem cell (BCSC) marker, CD44(+)/CD24(-)/ALDH1(+) The results indicated that Hs578T and MDA-MB-231 cell lines with CD44(+)/CD24(-)/ALDH1(+) phenotype were significantly more deformable than the MDA-MB-468 cell line, which did not express the BCSC marker...
November 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29148579/a-step-by-step-review-on-patient-specific-biomechanical-finite-element-models-for-breast-mri-to-x-ray-mammography-registration
#2
REVIEW
Eloy García, Yago Diez, Oliver Diaz, Xavier Lladó, Robert Martí, Joan Martí, Arnau Oliver
Breast magnetic resonance imaging (MRI) and X-ray mammography are two image modalities widely used for the early detection and diagnosis of breast diseases in women. The combination of these modalities leads to a more accurate diagnosis and treatment of breast diseases. The aim of this paper is to review the registration between breast MRI and X-ray mammographic images using patient-specific finite element-based biomechanical models. Specifically, a biomechanical model is obtained from the patient's MRI volume and is subsequently used to mimic the mammographic acquisition...
November 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29147663/can-the-weight-of-an-external-breast-prosthesis-influence-trunk-biomechanics-during-functional-movement-in-postmastectomy-women
#3
Katarzyna Hojan, Faustyna Manikowska
Introduction: Recent papers indicate that one-side mastectomy can produce deleterious effects on the posture and musculoskeletal system. This study was conducted to better understand the underlying mechanisms involved in trunk motion in external prosthesis users. Objective: The aim was to evaluate the changes in surface electromyographic (SEMG) activity of the erector spinae muscles (ES) in postmastectomy women with and without breast prostheses during functional body movement tests...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29096610/therapy-response-testing-of-breast-cancer-in-a-3d-high-throughput-perfused-microfluidic-platform
#4
Henriette L Lanz, Anthony Saleh, Bart Kramer, Junmei Cairns, Chee Ping Ng, Jia Yu, Sebastiaan J Trietsch, Thomas Hankemeier, Jos Joore, Paul Vulto, Richard Weinshilboum, Liewei Wang
BACKGROUND: Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set up and assay. In this report, we introduce a microfluidic OrganoPlate® platform for extracellular matrix (ECM) embedded tumor culture under perfusion as an initial study designed to investigate the feasibility of adapting this technology for therapy selection. METHODS: The triple negative breast cancer cell lines MDA-MB-453, MDA-MB-231 and HCC1937 were selected based on their different BRCA1 and P53 status, and were seeded in the platform...
November 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29076508/challenging-metastatic-breast-cancer-with-the-natural-defensin-pvd1
#5
Tiago N Figueira, Filipa D Oliveira, Inês Almeida, Érica O Mello, Valdirene M Gomes, Miguel A R B Castanho, Diana Gaspar
Metastatic breast cancer is a very serious life threatening condition that poses many challenges for the pharmaceutical development of effective chemotherapeutics. As the therapeutics targeted to the localized masses in breast improve, metastatic lesions in the brain slowly increase in their incidence compromising successful treatment outcomes overall. The blood-brain-barrier (BBB) is one important obstacle for the management of breast cancer brain metastases. New therapeutic approaches are in demand for overcoming the BBB's breaching by breast tumor cells...
November 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/29073719/value-of-whole-breast-magnetic-resonance-elastography-added-to-mri-for-lesion-characterization
#6
Corinne Balleyguier, Aicha Ben Lakhdar, Ariane Dunant, Marie-Christine Mathieu, Suzette Delaloge, Ralph Sinkus
The purpose of this work was to assess the diagnostic value of magnetic resonance elastography (MRE) in addition to MRI to differentiate malignant from benign breast tumors, and the feasibility of performing MRE on the whole breast. MRE quantified biomechanical properties within the entire breast (50 slices) using an 11 min acquisition protocol at an isotropic image acquisition resolution of 2 × 2 × 2 mm(3) . Fifty patients were included. Finally, 43 patients (median age 52) with a suspect breast lesion detected by mammography and/or ultrasound were examined by MRI and MRE at 1...
October 26, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29034007/microfluidic-iterative-mechanical-characteristics-imech-analyzer-for-single-cell-metastatic-identification
#7
Hesam Babahosseini, Jeannine S Strobl, Masoud Agah
This study describes the development of a microfluidic biosensor called the iterative mechanical characteristics (iMECH) analyzer which enables label-free biomechanical profiling of individual cells for distinction between metastatic and non-metastatic human mammary cell lines. Previous results have demonstrated that pulsed mechanical nanoindentation can modulate the biomechanics of cells resulting in distinctly different biomechanical responses in metastatic and non-metastatic cell lines. The iMECH analyzer aims to move this concept into a microfluidic, clinically more relevant platform...
February 7, 2017: Analytical Methods: Advancing Methods and Applications
https://www.readbyqxmd.com/read/28982035/a-finite-element-based-machine-learning-approach-for-modeling-the-mechanical-behavior-of-the-breast-tissues-under-compression-in-real-time
#8
F Martínez-Martínez, M J Rupérez-Moreno, M Martínez-Sober, J A Solves-Llorens, D Lorente, A J Serrano-López, S Martínez-Sanchis, C Monserrat, J D Martín-Guerrero
This work presents a data-driven method to simulate, in real-time, the biomechanical behavior of the breast tissues in some image-guided interventions such as biopsies or radiotherapy dose delivery as well as to speed up multimodal registration algorithms. Ten real breasts were used for this work. Their deformation due to the displacement of two compression plates was simulated off-line using the finite element (FE) method. Three machine learning models were trained with the data from those simulations. Then, they were used to predict in real-time the deformation of the breast tissues during the compression...
September 28, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28935466/morphomechanical-and-structural-changes-induced-by-rock-inhibitor-in-breast-cancer-cells
#9
Mariafrancesca Cascione, Valeria De Matteis, Chiara Cristina Toma, Paolo Pellegrino, Stefano Leporatti, Rosaria Rinaldi
The EMT phenomenon is based on tumour progression. The cells lose their physiologic phenotype and assumed a mesenchymal phenotype characterized by an increased migratory capacity, invasiveness and high resistance to apoptosis. In this process, RHO family regulates the activation or suppression of ROCK (Rho-associated coiled-coil containing protein kinase) which in turn regulates the cytoskeleton dynamics. However, while the biochemical mechanisms are widely investigated, a comprehensive and careful estimation of biomechanical changes has not been extensively addressed...
November 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28919351/suspension-state-increases-reattachment-of-breast-cancer-cells-by-up-regulating-lamin-a-c
#10
Xiaomei Zhang, Yonggang Lv
Extravasation is a rate-limiting step of tumor metastasis, for which adhesion to endothelium of circulating tumor cells (CTCs) is the prerequisite. The suspension state of CTCs undergoing detachment from primary tumor is a persistent biomechanical cue, which potentially regulates the biophysical characteristics and cellular behaviors of tumor cells. In this study, breast tumor cells MDA-MB-231 in suspension culture condition were used to investigate the effect of suspension state on reattachment of CTCs. Our study demonstrated that suspension state significantly increased the adhesion ability of breast tumor cells...
December 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28885152/multimodal-breast-parenchymal-patterns-correlation-using-a-patient-specific-biomechanical-model
#11
Eloy Garcia, Yago Diez, Oliver Diaz, Xavier Llado, Albert Gubern-Merida, Robert Marti, Joan Marti, Arnau Oliver
In this paper we aim to produce a realistic 2D projection of the breast parenchymal distribution from a 3D breast magnetic resonance image (MRI). To evaluate the accuracy of our simulation, we compare our results with the local breast density (i.e. density map) obtained from the complementary fullfield digital mammogram. To achieve this goal, we have developed a fully automatic framework which registers MRI volumes to X-ray mammograms using a subject-specific biomechanical model of the breast. The optimization step modifies the position, orientation and elastic parameters of the breast model to perform the alignment between the images...
September 7, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28729775/role-of-tumor-microenvironment-in-triple-negative-breast-cancer-and-its-prognostic-significance
#12
Tianjian Yu, Genhong Di
Breast cancer has been shown to live in the tumor microenvironment, which consists of not only breast cancer cells themselves but also a significant amount of pathophysiologically altered surrounding stroma and cells. Diverse components of the breast cancer microenvironment, such as suppressive immune cells, re-programmed fibroblast cells, altered extracellular matrix (ECM) and certain soluble factors, synergistically impede an effective anti-tumor response and promote breast cancer progression and metastasis...
June 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28667516/atomic-force-microscopy-studies-on-cellular-elastic-and-viscoelastic-properties
#13
Mi Li, Lianqing Liu, Ning Xi, Yuechao Wang
In this work, a method based on atomic force microscopy (AFM) approach-reside-retract experiments was established to simultaneously quantify the elastic and viscoelastic properties of single cells. First, the elastic and viscoelastic properties of normal breast cells and cancerous breast cells were measured, showing significant differences in Young's modulus and relaxation times between normal and cancerous breast cells. Remarkable differences in cellular topography between normal and cancerous breast cells were also revealed by AFM imaging...
June 29, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28652253/spin90-depletion-and-microtubule-acetylation-mediate-stromal-fibroblast-activation-in-breast-cancer-progression
#14
Eunae You, Yun Hyun Huh, Ahreum Kwon, So Hee Kim, In Hee Chae, Ok-Jun Lee, Je-Hwang Ryu, Min Ho Park, Ga-Eon Kim, Ji Shin Lee, Kun Ho Lee, Yong-Seok Lee, Jung-Woong Kim, Sangmyung Rhee, Woo Keun Song
Biomechanical remodeling of stroma by cancer-associated fibroblasts (CAF) in early stages of cancer is critical for cancer progression, and mechanical cues such as extracellular matrix stiffness control cell differentiation and malignant progression. However, the mechanism by which CAF activation occurs in low stiffness stroma in early stages of cancer is unclear. Here, we investigated the molecular mechanism underlying CAF regulation by SPIN90 and microtubule acetylation under conditions of mechanically soft matrices corresponding to normal stromal rigidity...
September 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28614671/gestalt-breastfeeding-helping-mothers-and-infants-optimize-positional-stability-and-intraoral-breast-tissue-volume-for-effective-pain-free-milk-transfer
#15
Pamela Douglas, Renee Keogh
In the past decade, biological nurturing and activation of maternal and infant instincts after birth have constituted a major advance in clinical breastfeeding support. Yet, physiologic breastfeeding initiation is not enough to ensure ongoing pain-free and effective breastfeeding for many pairs. Current interventions, including "hands-off" mammalian approaches, do not improve breastfeeding outcomes, including in randomized controlled trials. Back-arching, difficulty latching or staying on the breast, and fussing at the breast are common signs of infant positional instability during breastfeeding...
August 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28520556/breast-tissue-stiffness-estimation-for-surgical-guidance-using-gravity-induced-excitation
#16
Rebekah H Griesenauer, Jared A Weis, Lori R Arlinghaus, Ingrid M Meszoely, Michael I Miga
Tissue stiffness interrogation is fundamental in breast cancer diagnosis and treatment. Furthermore, biomechanical models for predicting breast deformations have been created for several breast cancer applications. Within these applications, constitutive mechanical properties must be defined and the accuracy of this estimation directly impacts the overall performance of the model. In this study, we present an image-derived computational framework to obtain quantitative, patient specific stiffness properties for application in image-guided breast cancer surgery and interventions...
June 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28428257/the-size-speed-force-relationship-governs-migratory-cell-response-to-tumorigenic-factors
#17
Aldo Leal-Egaña, Gaelle Letort, Jean-Louis Martiel, Andreas Christ, Timothée Vignaud, Caroline Roelants, Odile Filhol, Manuel Théry
Tumor development progresses through a complex path of biomechanical changes leading first to cell growth and contraction and then cell deadhesion, scattering, and invasion. Tumorigenic factors may act specifically on one of these steps or have a wider spectrum of actions, leading to a variety of effects and thus sometimes to apparent contradictory outcomes. Here we used micropatterned lines of collagen type I/fibronectin on deformable surfaces to standardize cell behavior and measure simultaneously cell size, speed of motion and magnitude of the associated traction forces at the level of a single cell...
June 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28270967/normalization-of-compression-induced-hemodynamics-in-patients-responding-to-neoadjuvant-chemotherapy-monitored-by-dynamic-tomographic-optical-breast-imaging-dtobi
#18
Amir Y Sajjadi, Steven J Isakoff, Bin Deng, Bhawana Singh, Christy M Wanyo, Qianqian Fang, Michelle C Specht, Lidia Schapira, Beverly Moy, Aditya Bardia, David A Boas, Stefan A Carp
We characterize novel breast cancer imaging biomarkers for monitoring neoadjuvant chemotherapy (NACT) and predicting outcome. Specifically, we recruited 30 patients for a pilot study in which NACT patients were imaged using dynamic tomographic optical breast imaging (DTOBI) to quantify the hemodynamic changes due to partial mammographic compression. DTOBI scans were obtained pre-treatment (referred to as day 0), as well as 7 and 30 days into therapy on female patients undergoing NACT. We present data for the 13 patients who participated in both day 0 and 7 measurements and had evaluable data, of which 7 also returned for day 30 measurements...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28228783/-atypical-atypical-femur-fractures-and-use-of-bisphosphonates
#19
Denise M van de Laarschot, Matthijs P Somford, Agnes Jager, Edwin H Oei, P Koen Bos, M Carola Zillikens
BACKGROUND: Atypical femur fractures (AFFs) present a rare but serious condition associated with use of bisphosphonates. Underlying mechanisms and clinical risk factors remain unclear. According to the diagnostic criteria formulated by the ASBMR, a lateral localization of an AFF is required. CASE HISTORY: We present a patient who developed bilateral leg pain while using an oral bisphosphonate and aromatase inhibitor in the course of adjuvant treatment for breast cancer...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28042181/three-dimensional-image-based-mechanical-modeling-for-predicting-the-response-of-breast-cancer-to-neoadjuvant-therapy
#20
Jared A Weis, Michael I Miga, Thomas E Yankeelov
The use of quantitative medical imaging data to initialize and constrain mechanistic mathematical models of tumor growth has demonstrated a compelling strategy for predicting therapeutic response. More specifically, we have demonstrated a data-driven framework for prediction of residual tumor burden following neoadjuvant therapy in breast cancer that uses a biophysical mathematical model combining reaction-diffusion growth/therapy dynamics and biomechanical effects driven by early time point imaging data. Whereas early work had been based on a limited dimensionality reduction (two-dimensional planar modeling analysis) to simplify the numerical implementation, in this work, we extend our framework to a fully volumetric, three-dimensional biophysical mathematical modeling approach in which parameter estimates are generated by an inverse problem based on the adjoint state method for numerical efficiency...
February 1, 2017: Computer Methods in Applied Mechanics and Engineering
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