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https://www.readbyqxmd.com/read/28214659/clinical-outcomes-and-prognostic-factors-of-patients-with-advanced-mesothelioma-treated-in-a-phase-i-clinical-trials-unit
#1
Dionysis Papadatos-Pastos, Desam Roda, Maria Jose De Miguel Luken, Ann Petruckevitch, Awais Jalil, Marta Capelan, Vasiliki Michalarea, Joao Lima, Nikolaos Diamantis, Jaishree Bhosle, L Rhoda Molife, Udai Banerji, Johann S de Bono, Sanjay Popat, Mary E R O'Brien, Timothy A Yap
BACKGROUND: We have previously reported a prognostic score for patients in phase I trials in the Drug Development Unit, treated at the Royal Marsden Hospital (RPS). The RPS is an objective tool used in patient selection for phase I trials based on albumin, number of disease sites and LDH. Patients with mesothelioma are often selected for phase I trials as the disease remains localised for long periods of time. We have now reviewed the clinical outcomes of patients with relapsed malignant mesothelioma (MM) and propose a specific mesothelioma prognostic score (m-RPS) that can help identify patients who are most likely to benefit from early referral...
February 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28214647/fate-of-antimicrobials-in-duckweed-lemna-minor-wastewater-treatment-systems
#2
Evangelia I Iatrou, Georgia Gatidou, Dimitrios Damalas, Nikolaos S Thomaidis, Athanasios S Stasinakis
The fate of four antimicrobials (cefadroxil, CFD; metronidazole, METRO; trimethoprim, TRI; sulfamethoxazole, SMX) was studied in Lemna minor systems and the role of different mechanisms on their removal was evaluated. All micropollutants were significantly removed in batch experiments with active Lemna minor; the highest removal was observed for CFD (100% in 14 d), followed by METRO (96%), SMX (73%) and TRI (59%) during 24 d of the experiment. Calculation of kinetic constants for hydrolysis, photodegradation, sorption to biomass and plant uptake revealed significant differences depending on the compound and the studied mechanism...
February 13, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28213067/duodenal-gangliocytic-paraganglioma-successfully-treated-by-local-surgical-excision-a-case-report
#3
Dimetrios Papaconstantinou, Nikolaos Machairas, Vasileia Damaskou, Nikolaos Zavras, Christine Kontopoulou, Anastasios Machairas
INTRODUCTION: Duodenal gangliocytic paragangliomas are rare neoplasms often arising in proximity to the major duodenal papilla of Vater. These neoplasms are considered to have a benign behavior with lymph node metastases being a rare phenomenon and distant metastatic disease even more so. Resection of the tumor is the only definitive therapy. PRESENTATION OF CASE: A 67year old male presented to a referring hospital with symptoms of fatigue and malaise. Evaluation with CT imaging revealed a 3...
January 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28212870/the-174-g-c-interleukin-6-gene-polymorphism-is-associated-with-angiographic-progression-of-coronary-artery-disease-in-a-4-year-period
#4
Konstantinos Toutouzas, Dimitrios Klettas, Nikolaos Anousakis-Vlachochristou, Konstantinos Melidis, Zeta Azilazian, Maria Asimomiti, Antonios Karanasos, Anastasios Spanos, Eleftherios Tsiamis, Petros Nihoyannopoulos, Dimitris Tousoulis
BACKGROUND: Inflammation is the key process underlying the clinical course of coronary artery disease (CAD). C-reactive protein (CRP) and interleukin-6 (IL-6) participate in the pathophysiology and act as biomarkers. We sought to examine whether known single nucleotide polymorphisms (SNPs) impact the progression of CAD, reflecting higher inflammatory activity. METHODS: We retrospectively evaluated coronary angiographies of patients with already established CAD who were re-investigated for stable/unstable angina after a time interval >12 months...
February 14, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28212853/long-term-survival-after-resection-of-sentinel-node-metastatic-renal-cell-carcinoma
#5
Teele Kuusk, Jeroen De Jong, Nikolaos Grivas, Simon Horenblas, Axel Bex
We present a case of a patient who took part in a prospective sentinel lymph node (SN) study to investigate the drainage pattern from renal tumors. The patient was treated with laparoscopic radical nephrectomy (LRN), SN and non-SN lymph node dissection (LND) for a clinically node negative (cN0) left renal tumor of 6 cm (cT1b). Histopathological examination revealed a papillary type 2 pT1b renal cell carcinoma (RCC) with two para-aortic metastatic SNs (pN1). No adjuvant treatment was applied. The patient is free of disease at 63 months after surgery...
February 14, 2017: Urology
https://www.readbyqxmd.com/read/28212265/variations-in-oxidative-stress-levels-in-3-days-follow-up-in-ultramarathon-mountain-race-athletes
#6
Ypatios Spanidis, Dimitrios Stagos, Marina Orfanou, Nikolaos Goutzourelas, David Bar-Or, Demetrios Spandidos, Demetrios Kouretas
Spanidis, Y, Stagos, D, Orfanou, M, Goutzourelas, N, Bar-or, D, Spandidos, D, and Kouretas, D. Variations in oxidative stress levels in 3 days follow-up in ultramarathon mountain race athletes. J Strength Cond Res 31(3): 582-594, 2017-The aim of the present study was the monitoring of the redox status of runners participating in a mountain ultramarathon race of 103 km. Blood samples from 12 runners were collected prerace and 24, 48, and 72 hours postrace. The samples were analyzed by using conventional oxidative stress markers, such as protein carbonyls (CARB), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) in plasma, as well as glutathione (GSH) levels and catalase (CAT) activity in erythrocytes...
March 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28211512/physiology-and-role-of-irisin-in-glucose-homeostasis
#7
REVIEW
Nikolaos Perakakis, Georgios A Triantafyllou, José Manuel Fernández-Real, Joo Young Huh, Kyung Hee Park, Jochen Seufert, Christos S Mantzoros
Irisin is a myokine that leads to increased energy expenditure by stimulating the 'browning' of white adipose tissue. In the first description of this hormone, increased levels of circulating irisin, which is cleaved from its precursor fibronectin type III domain-containing protein 5, were associated with improved glucose homeostasis by reducing insulin resistance. Consequently, several studies attempted to characterize the role of irisin in glucose regulation, but contradictory results have been reported, and even the existence of this hormone has been questioned...
February 17, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28210806/the-current-state-of-orthopaedic-residency-in-18-european-countries
#8
Rami Madanat, Tatu J Mäkinen, Daniel Ryan, Gazi Huri, Nikolaos Paschos, Joao Vide
PURPOSE: The aim of this study was to compare differences in current orthopaedic and trauma training programs across Europe. METHODS: A questionnaire was sent to the FORTE (Federation of Orthopaedic Trainees in Europe) representatives of 25 different European countries, of which 18 responded. The questionnaire included demographic information and information concerning the structure of the training programs, including duration, selection, and mandatory training requirements...
February 16, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28210560/sinusoidal-hemangioma-of-the-breast-diagnostic-evaluation-management-and-literature-review
#9
Nikolaos S Salemis
Vascular tumors of the breast are rare and may pose a diagnostic challenge. Breast hemangioma is a very rare benign vascular neoplasm accounting for 0.4% of all breast tumors. It is most commonly detected as an incidental microscopic finding in biopsy specimens obtained for unrelated reasons. We describe here a very rare case of a sinusoidal breast hemangioma in a postmenopausal patient who presented with a palpable breast mass. A complete surgical resection was performed because the tumor exhibited atypical imaging features...
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28210516/immunohistochemical-investigation-of-her-akt-mtor-pathway-and-cellular-adhesion-molecules-in-urothelial-carcinomas
#10
Nikolaos Koletsas, Triantafyllia Koletsa, Spyros Choidas, Konstantinos Anagnostopoulos, Stavros Touloupidis, Thomas Zaramboukas, Georgia Raptou, Nikolaos Papadopoulos, Maria Lambropoulou
Background. Several investigators have suggested the possibility that the expression of both EGFR and HER2 could be utilized for molecularly targeted therapy in urinary bladder cancer. We tried to evaluate the expression of HER2 and EGFR and activation of the AKT/PTEN/mTOR pathway in urothelial carcinomas and if there is any association between them and cellular adhesion molecules (CAMs). Materials and Methods. Forty-one paraffin-embedded urothelial cancer tissue blocks were collected. Immunostains for HER2, EGFR, MIB1, phospho-AKT, PTEN, phospho-mTOR, e-cadherin, p-cadherin, and b-catenin were performed on tissue microarrays sections...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28210457/non-healing-tongue-ulcer-in-a-rheumatoid-arthritis-patient-medicated-with-leflunomide-an-adverse-drug-event
#11
Eleni-Marina Kalogirou, Nikolaos Katsoulas, Konstantinos I Tosios, Andreas C Lazaris, Alexandra Sklavounou
Leflunomide is a member of the disease modifying anti-rheumatic drugs group used as a treatment modality in active rheumatoid and psoriatic arthritis. "Oral ulcers" are reported in 3-5% of leflunomide medicated rheumatoid arthritis patients with adverse events, but they are not described in detail in the literature. We present a case of an ulcer in the tongue of a rheumatoid arthritis patient managed with leflunomide and contemplate on its pathogenesis. Key words:Leflunomide, oral ulcer, DHODH.
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210300/chest-radiograph-of-an-asymptomatic-man
#12
Eleftheria Chaini, Niki Giannakou, Dimitra Haini, Anna Maria Athanassiadou, Angelos Tsipis, Nikolaos D Hainis
Case report: An asymptomatic man undergoes a chest radiograph http://ow.ly/4nmyfG.
September 2016: Breathe
https://www.readbyqxmd.com/read/28209819/draft-genome-sequence-of-actinomyces-glycerinitolerans-strain-g10-t-isolated-from-sheep-rumen-fluid
#13
Susakul Palakawong Na Ayudthaya, Nikolaos Strepis, Peter Pristaš, Caroline M Plugge
Actinomyces glycerinitolerans strain G10(T), which was isolated from sheep rumen fluid, can metabolize a range of substrates, including complex carbohydrates to organic acids (OAs). Here, we report a 3.69-Mbp draft genome of Actinomyces glycerinitolerans.
February 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28209517/inadvertent-hypothermia-and-mortality-in-critically-ill-adults-systematic-review-and-meta-analysis
#14
REVIEW
Panagiotis Kiekkas, Fotini Fligou, Michael Igoumenidis, Nikolaos Stefanopoulos, Evangelos Konstantinou, Vasilios Karamouzos, Diamanto Aretha
OBJECTIVE: Considering that inadvertent hypothermia (IH) is common in Intensive Care Unit (ICU) patients and can be followed by severe complications, this systematic review identified, appraised and synthesized the published literature about the association between IH and mortality in adults admitted to the ICU. DATA SOURCES: By using key terms, literature searches were conducted in Pubmed, CINAHL, Cochrane Library, Web of Science and EMBASE. REVIEW METHODS: According to PRISMA guidelines, articles published between 1980-2016 in English-language, peer-reviewed journals were considered...
February 13, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28209179/the-social-brain-network-in-22q11-2-deletion-syndrome-a-diffusion-tensor-imaging-study
#15
Amy K Olszewski, Zora Kikinis, Christie S Gonzalez, Ioana L Coman, Nikolaos Makris, Xue Gong, Yogesh Rathi, Anni Zhu, Kevin M Antshel, Wanda Fremont, Marek R Kubicki, Sylvain Bouix, Martha E Shenton, Wendy R Kates
BACKGROUND: Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with a 25-fold increase in schizophrenia. Both individuals with 22q11.2DS and those with schizophrenia present with social cognitive deficits, which are putatively subserved by a network of brain regions that are involved in the processing of social cognitive information. This study used two-tensor tractography to examine the white matter tracts believed to underlie the social brain network in a group of 57 young adults with 22q11...
February 16, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/28208993/preliminary-sem-observations-on-the-surface-of-elastomeric-impression-materials-after-immersion-or-ozone-disinfection
#16
Nikolas Poulis, Anthony Prombonas, Stavros Yannikakis, Thanasis Karampotsos, Martha-Spyridoula Katsarou, Nikolaos Drakoulis
INTRODUCTION: Surface integrity of dental elastomeric impression materials that are subjected to disinfection is of major importance for the quality of the final prosthetic restorations. AIM: The aim of this qualitative Scanning Electronic Microscopy (SEM) study was to reveal the effects of immersion or ozone disinfection on the surface of four dental elastomeric impression materials. MATERIALS AND METHODS: Four dental elastomeric impression material brands were used (two vinyl polysiloxane silicones, one polyether, and one vinyl polyether silicone)...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208144/conservative-versus-surgical-management-of-iatrogenic-tracheal-rupture
#17
Nikolaos Panagiotopoulos, Davide Patrini, Matthew Barnard, Efstratios Koletsis, Dimitrios Dougenis, David Lawrence
Iatrogenic tracheal rupture (ITR) represents a life-threatening condition requiring prompt diagnosis, management, and treatment. The management of ITR is challenging, and treatment options depend on tear location, size, injury extent, and the patient's respiratory status. Although this complication has been extensively reported in published literature, the best evidence practice, for the management, requires clarification. In this review, the authors focused on the establishment of a differential diagnosis and the potential mechanism of the injury, the decision-making process, and the therapeutic approaches...
January 9, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28207741/visceral-leishmaniasis-during-pregnancy-a-rare-case-report-from-greece
#18
Periklis Panagopoulos, Vasileios Mitsopoulos, Antonios Papadopoulos, Spyridoula Theodorou, Chrysoula Christodoulaki, Kyriakos Aloupogiannis, Nikolaos Papantoniou
No abstract text is available yet for this article.
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28207440/be-focused-the-time-is-now
#19
Nikolaos J Skubas, Kent H Rehfeldt, W Scott Beattie
No abstract text is available yet for this article.
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28206918/y-type-anovulvar-fistula-complicating-inflammatory-bowel-disease
#20
Georgios-Marios Makris, Anestis Charalampopoulos, Charalampos Siristatidis, Dimitra Fexi, Charalampos Chrelias, Marco-Johannes Battista, Nikolaos Papantoniou
No abstract text is available yet for this article.
November 1, 2016: American Surgeon
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