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https://www.readbyqxmd.com/read/29917059/optimality-and-identification-of-dynamic-models-in-systems-biology-an-inverse-optimal-control-framework
#1
Nikolaos Tsiantis, Eva Balsa-Canto, Julio R Banga
No abstract text is available yet for this article.
June 15, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29916883/reply-to-precision-surgery-for-colorectal-liver-metastases-is-the-time-ripe
#2
Georgios Antonios Margonis, Nikolaos Andreatos, Christopher L Wolfgang, Matthew J Weiss
No abstract text is available yet for this article.
June 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29916772/triple-arterial-phase-ct-of-the-liver-with-radiation-dose-equivalent-to-that-of-single-arterial-phase-ct-initial-experience
#3
Katharina Brehmer, Torkel B Brismar, Fabian Morsbach, Anders Svensson, Per Stål, Antonios Tzortzakakis, Nikolaos Voulgarakis, Michael A Fischer
Purpose To develop and evaluate a triple arterial phase CT liver protocol with a similar radiation dose to that of standard single arterial phase CT in study subjects suspected of having hepatocellular carcinoma (HCC). Materials and Methods The study consisted of a retrospective part A for protocol development (n = 15) and a prospective part B to evaluate diagnostic accuracy (n = 38). All 53 participants underwent perfusion CT with 50 mL contrast material between August 2013 and September 2014. Group B underwent an additional standard multiphasic liver CT examination with 120 mL of contrast material (range, 70-143 mL)...
June 19, 2018: Radiology
https://www.readbyqxmd.com/read/29915220/predicta-chip-based-high-resolution-diagnosis-of-rhinovirus-induced-wheeze
#4
Katarzyna Niespodziana, Katarina Stenberg-Hammar, Spyridon Megremis, Clarissa R Cabauatan, Kamila Napora-Wijata, Phyllis C Vacal, Daniela Gallerano, Christian Lupinek, Daniel Ebner, Thomas Schlederer, Christian Harwanegg, Cilla Söderhäll, Marianne van Hage, Gunilla Hedlin, Nikolaos G Papadopoulos, Rudolf Valenta
Rhinovirus (RV) infections are major triggers of acute exacerbations of severe respiratory diseases such as pre-school wheeze, asthma and chronic obstructive pulmonary disease (COPD). The occurrence of numerous RV types is a major challenge for the identification of the culprit virus types and for the improvement of virus type-specific treatment strategies. Here, we develop a chip containing 130 different micro-arrayed RV proteins and peptides and demonstrate in a cohort of 120 pre-school children, most of whom had been hospitalized due to acute wheeze, that it is possible to determine the culprit RV species with a minute blood sample by serology...
June 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29914800/the-respiratory-syncytial-virus-vaccine-landscape-lessons-from-the-graveyard-and-promising-candidates
#5
REVIEW
Natalie I Mazur, Deborah Higgins, Marta C Nunes, José A Melero, Annefleur C Langedijk, Nicole Horsley, Ursula J Buchholz, Peter J Openshaw, Jason S McLellan, Janet A Englund, Asuncion Mejias, Ruth A Karron, Eric Af Simões, Ivana Knezevic, Octavio Ramilo, Pedro A Piedra, Helen Y Chu, Ann R Falsey, Harish Nair, Leyla Kragten-Tabatabaie, Anne Greenough, Eugenio Baraldi, Nikolaos G Papadopoulos, Johan Vekemans, Fernando P Polack, Mair Powell, Ashish Satav, Edward E Walsh, Renato T Stein, Barney S Graham, Louis J Bont
The global burden of disease caused by respiratory syncytial virus (RSV) is increasingly recognised, not only in infants, but also in older adults (aged ≥65 years). Advances in knowledge of the structural biology of the RSV surface fusion glycoprotein have revolutionised RSV vaccine development by providing a new target for preventive interventions. The RSV vaccine landscape has rapidly expanded to include 19 vaccine candidates and monoclonal antibodies (mAbs) in clinical trials, reflecting the urgency of reducing this global health problem and hence the prioritisation of RSV vaccine development...
June 15, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29913280/emricasan-improves-liver-function-in-patients-with-cirrhosis-and-high-model-for-end-stage-liver-disease-scores-compared-with-placebo
#6
Catherine T Frenette, Giuseppe Morelli, Mitchell L Shiffman, R Todd Frederick, Raymond A Rubin, Michael B Fallon, Jason T Cheng, Matt Cave, Saira A Khaderi, Omar Massoud, Nikolaos Pyrsopoulos, James S Park, James M Robinson, Mason Yamashita, Alfred P Spada, Jean L Chan, David T Hagerty
BACKGROUND & AIMS: Caspase-mediated apoptosis and inflammation contribute to progression of liver disease. Emricasan is a pan-caspase inhibitor that reduced serum markers of apoptosis and liver inflammation in patients with hepatitis C and non-alcoholic steatohepatitis (NASH). METHODS: We performed a multicenter study of 86 patients with cirrhosis (Child-Pugh class A or B; mean score, 6.9; 38% with alcohol-associated cirrhosis, 29% with HCV-associated cirrhosis, and 23% with NASH) and model for end-stage liver disease (MELD) scores of 11-18 (mean, 12...
June 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29911349/tales-around-the-clock-poly-a-tails-in-circadian-gene-expression
#7
REVIEW
Rafailia A A Beta, Nikolaos A A Balatsos
Circadian rhythms are ubiquitous time-keeping processes in eukaryotes with a period of ~24 hr. Light is perhaps the main environmental cue (zeitgeber) that affects several aspects of physiology and behaviour, such as sleep/wake cycles, orientation of birds and bees, and leaf movements in plants. Temperature can serve as the main zeitgeber in the absence of light cycles, even though it does not lead to rhythmicity through the same mechanism as light. Additional cues include feeding patterns, humidity, and social rhythms...
June 17, 2018: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/29909983/phenotypic-convergence-distinct-transcription-factors-regulate-common-terminal-features
#8
Nikolaos Konstantinides, Katarina Kapuralin, Chaimaa Fadil, Luendreo Barboza, Rahul Satija, Claude Desplan
Transcription factors regulate the molecular, morphological, and physiological characteristics of neurons and generate their impressive cell-type diversity. To gain insight into the general principles that govern how transcription factors regulate cell-type diversity, we used large-scale single-cell RNA sequencing to characterize the extensive cellular diversity in the Drosophila optic lobes. We sequenced 55,000 single cells and assigned them to 52 clusters. We validated and annotated many clusters using RNA sequencing of FACS-sorted single-cell types and cluster-specific genes...
June 9, 2018: Cell
https://www.readbyqxmd.com/read/29909906/microrna-155-185-and-193b-as-biomarkers-in-human-papillomavirus-positive-and-negative-tonsillar-and-base-of-tongue-squamous-cell-carcinoma
#9
Cinzia Bersani, Michael Mints, Nikolaos Tertipis, Linnea Haeggblom, Anders Näsman, Mircea Romanitan, Tina Dalianis, Torbjörn Ramqvist
OBJECTIVE: Three-year disease-free survival (DFS) is 80% for human papillomavirus (HPV) positive tonsillar and base of tongue cancer (TSCC/BOTSCC) treated with radiotherapy alone, and today's intensified therapy does not improve prognosis. More markers are therefore needed to more accurately identify patients with good prognosis or in need of alternative therapy. Here, microRNAs (miRs) 155, 185 and 193b were examined as potential prognostic markers in TSCC/BOTSCC. MATERIAL AND METHODS: 168 TSCC/BOTSCC patients diagnosed 2000-2013, with known data on HPV-status, CD8+ tumour infiltrating lymphocytes, tumour staging and survival were examined for expression of miR-155, -185 and -193b using Real-Time PCR...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29908990/development-and-validation-of-response-markers-to-predict-survival-and-pleurodesis-success-in-patients-with-malignant-pleural-effusion-promise-a-multicohort-analysis
#10
Ioannis Psallidas, Nikolaos I Kanellakis, Stephen Gerry, Marie Laëtitia Thézénas, Philip D Charles, Anastasia Samsonova, Herbert B Schiller, Roman Fischer, Rachelle Asciak, Robert J Hallifax, Rachel Mercer, Melissa Dobson, Tao Dong, Ian D Pavord, Gary S Collins, Benedikt M Kessler, Harvey I Pass, Nick Maskell, Georgios T Stathopoulos, Najib M Rahman
BACKGROUND: The prevalence of malignant pleural effusion is increasing worldwide, but prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified. The PROMISE study was designed with the objectives to discover, validate, and prospectively assess biomarkers of survival and pleurodesis response in malignant pleural effusion and build a score that predicts survival. METHODS: In this multicohort study, we used five separate and independent datasets from randomised controlled trials to investigate potential biomarkers of survival and pleurodesis...
June 13, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29908795/an-unusual-case-of-pasteurella-multocida-bacteremic-meningitis
#11
Nikolaos Katechakis, Sofia Maraki, Irini Dramitinou, Eleni Marolachaki, Christina Koutla, Eleni Ioannidou
Pasteurella multocida is a rare cause of bacterial meningitis, more frequently affecting humans at the extremes of age. We report a case of meningitis and bacteremia caused by P. multocida in a 67-year-old diabetic woman who was living with 10 cats. She didn't have any animal bites or scratches, but she reported kissing the pets in the mouth. The outcome was favorable following antimicrobial treatment. Although rarely encountered, P. multocida should be considered as a possible cause of meningitis, particularly when Gram-negative coccobacilli are revealed in the cerebrospinal fluid and a history of recent animal contact is present...
June 13, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29908190/transcatheter-aortic-valve-replacement-in-a-patient-with-dextrocardia-and-situs-inversus-totalis
#12
Gregory Pattakos, Michael Chrissoheris, Antonios Halapas, Konstantinos Papadopoulos, Panagiota Kourkoveli, Nikolaos Bouboulis, Stratis Pattakos, Konstantinos Spargias
This report presents the case of an 82 year old male with known dextrocardia and situs inversus totalis who developed increasing dyspnea on exertion and was diagnosed with severe aortic stenosis. Transcatheter aortic valve replacement was decided upon requiring deviation from standard techniques for patients with normal anatomy and left-sided aortic arch. We describe two technical differences required for patients with dextrocardia and right-sided aortic arch which facilitate transcatheter aortic valve replacement in this patient group...
June 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29907945/neoadjuvant-proton-beam-irradiation-vs-adjuvant-ruthenium-brachytherapy-in-transscleral-resection-of-uveal-melanoma
#13
Alexander Böker, Daniel Pilger, Dino Cordini, Ira Seibel, Aline I Riechardt, Antonia M Joussen, Nikolaos E Bechrakis
BACKGROUND: Uveal melanoma is the most common primary ocular malignancy in adults in the USA and Europe. The optimal treatment of large uveal melanoma is still under debate. Radiation therapy has its limitation due its eye-threatening secondary complications and is therefore often combined with surgical excision of the tumor. METHODS: In a retrospective interventional review, we evaluated in total 242 patients with uveal melanoma that underwent transscleral tumor resection with a predefined protocol, either with adjuvant ruthenium brachytherapy (Ru-106 group, n 136,), or with neoadjuvant proton beam therapy (PBT group, n 106)...
June 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29907241/eating-habits-and-behaviors-of-older-people-where-are-we-now-and-where-should-we-go
#14
REVIEW
Mary Yannakoulia, Eirini Mamalaki, Costas A Anastasiou, Niki Mourtzi, Irene Lambrinoudaki, Nikolaos Scarmeas
Nutrition is a modifiable factor affecting the quality of life and independence of older people. The physiological, psychological and social changes during aging affect their dietary choices. Many older adults have inadequate energy and protein intake. Carbohydrate intake and intake of total lipids, in terms of contribution to total energy intake, generally are within the recommended levels, but a decline in overall energy intake as well as the limited variety of micronutrient-dense foods that older people tend to consume result in an inadequate intake of several micronutrients...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29907021/a-kirkwood-buff-derived-force-field-for-alkaline-earth-halide-salts
#15
Nawavi Naleem, Nikolaos Bentenitis, Paul E Smith
The activity and function of many macromolecules in cellular environments are coupled with the binding of divalent ions such as calcium or magnesium. In principle, computer simulations can be used to understand the molecular level aspects of how many important macromolecules interact with ions. However, most of the force fields currently available often fail to accurately reproduce the properties of divalent ions in aqueous environments. Here we develop classical non-polarizable force fields for the aqueous alkaline earth metal halides (MX2 ), where M = Mg2+ , Ca2+ , Sr2+ , Ba2+ and X = Cl- , Br- , I- , which can be used in bimolecular simulations and which are compatible with the Simple Point Charge/Extended (SPC/E) water model...
June 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29906154/convective-excitation-of-inertial-modes-in-binary-neutron-star-mergers
#16
Roberto De Pietri, Alessandra Feo, José A Font, Frank Löffler, Francesco Maione, Michele Pasquali, Nikolaos Stergioulas
We present the first very long-term simulations (extending up to ∼140  ms after merger) of binary neutron star mergers with piecewise polytropic equations of state and in full general relativity. Our simulations reveal that, at a time of 30-50 ms after merger, parts of the star become convectively unstable, which triggers the excitation of inertial modes. The excited inertial modes are sustained up to several tens of milliseconds and are potentially observable by the planned third-generation gravitational-wave detectors at frequencies of a few kilohertz...
June 1, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29904514/learning-science-communication-skills-using-improvisation-video-recordings-and-practice-practice-practice
#17
Nicholas M Ponzio, Janet Alder, Mary Nucci, David Dannenfelser, Holly Hilton, Nikolaos Linardopoulos, Carol Lutz
Doctoral students in science disciplines spend countless hours learning how to conduct cutting-edge research but very little time learning to communicate the nature and significance of their science to people outside their field. To narrow this disparity, we created an unusual course titled Communicating Science for doctoral science trainees at Rutgers University. Our goal was to help students develop an advanced ability to communicate their research clearly and accurately and to emphasize its value and significance to diverse audiences...
2018: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/29904438/the-use-of-serum-procalcitonin-as-a-diagnostic-and-prognostic-biomarker-in-chronic-obstructive-pulmonary-disease-exacerbations-a-literature-review-update
#18
REVIEW
Nikolaos-Dimitrios Pantzaris, Diamantina-Xanthi Spilioti, Aikaterini Psaromyalou, Ioanna Koniari, Dimitrios Velissaris
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major complication in COPD patients which can be triggered by bacterial or viral infections, environmental pollutants and other causes. Procalcitonin (PCT), a peptide that markedly increases in cases of bacterial infection, has been extensively investigated as a biomarker in the diagnosis, prognosis and treatment in patients with AECOPD. A number of studies published in the last decade, tried to investigate whether PCT levels can differentiate between bacterial and other causes of exacerbations, if they can be used as a guide for optimal antibiotic therapy and if they can be a tool in the assessment of the severity and the need for further interventions in the management of those patients...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29903416/comparison-between-nageotte-and-flow-cytometric-counting-of-residual-leucocytes-in-freshly-prepared-leucocyte-reduced-red-blood-cell-components
#19
Elias Kyriakou, Nikolaos Nearchakos, Stefanos Bonovas, Efstathia Makri, Katerina Pantavou, Georgios K Nikolopoulos, Christine Kottaridi, Argyri Gialeraki, Panagiota Douramani, Maria Taichert, Violetta Kapsimali, Argirios E Tsantes
BACKGROUND: Flow cytometry (FC) and Nageotte hemocytometry represent the most widely accepted methods for counting residual white blood cells (rWBCs) in leucocyte-reduced (LR) blood components. Our aim was to study the agreement between the two methods, under real working blood bank conditions. MATERIALS AND METHODS: 94 freshly produced LR red blood cell (RBC) units were tested for rWBC concentrations by FC and Nageotte. To assess the precision of each method, we calculated the intra-assay coefficients of variation (CV), and followed the Bland-Altman methodology to study the agreement between the two methods...
June 7, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29902519/the-association-between-sexually-transmitted-infections-human-papillomavirus-and-cervical-cytology-abnormalities-among-women-in-greece
#20
Christos Parthenis, Periklis Panagopoulos, Niki Margari, Christine Kottaridi, Aris Spathis, Abraham Pouliakis, Stefanos Konstantoudakis, George Chrelias, Charalambos Chrelias, Nikolaos Papantoniou, Ioannis G Panayiotides, Sotirios Tsiodras
OBJECTIVES: To investigate STIs diagnosis with HPV infection and the presence of cytological changes of the cervix in a cohort of sexually active women in Greece. METHODS: Cervical cytology testing, molecular typing of HPV and other STIs was performed in 345 sexually active women aged between 18 and 45 years (33.2±7.2) visiting a gynaecology clinic for routine cervical screening. We investigated the association of HPV and STI detection with cytological findings...
June 11, 2018: International Journal of Infectious Diseases: IJID
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