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https://www.readbyqxmd.com/read/29683664/assessment-of-the-acute-toxicity-uptake-and-biotransformation-potential-of-benzotriazoles-in-zebrafish-danio-rerio-larvae-combining-hilic-with-rplc-hrms-for-high-throughput-identification
#1
Dimitrios E Damalas, Anna A Bletsou, Adamantia Agalou, Dimitris Beis, Nikolaos S Thomaidis
The current study reports on the toxicity, uptake and the biotransformation potential of zebrafish (embryos and larvae) exposed to Benzotriazoles (BTs). Acute toxicity assays were conducted. Cardiac function abnormalities (pericardial edema and poor blood circulation) were observed from the phenotypic analysis of early life zebrafish embryos after BTs exposure. For the uptake and biotransformation experiment, extracts of whole body larvae were analyzed using liquid chromatography-high-resolution tandem mass spectrometry (UPLC-Q-TOF-HRMS/MS)...
April 23, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29682449/varicella-zoster-virus-meningitis-with-hypoglycorrhachia-in-a-young-immunocompetent-adult-without-rash-a-case-report-and-literature-review
#2
Nikolaos Spernovasilis, Athanasia Milioni, Ioannis Gialamas, Evangelos Kokorakis, Garufallia Fanti
Overt aseptic meningitis rarely complicates varicella-zoster virus (VZV) reactivation in young and immunocompetent adults. Many of the cases of VZV meningitis are associated with an exanthem. We describe an otherwise healthy 36-year-old adult who had aseptic meningitis without skin rash, caused by reactivation of varicella-zoster virus. Cerebrospinal fluid (CSF) analysis revealed lymphocytosis, increased total protein, and low glucose. Diagnosis was made by polymerase chain reaction in CSF. The present case highlights the fact that VZV should be considered as a cause of aseptic meningitis with hypoglycorrhachia in healthy and young individuals, even in the absence of an exanthem...
2018: IDCases
https://www.readbyqxmd.com/read/29682111/the-obsolete-maximum-diameter-criterion-the-evident-role-of-biomechanical-pressure-indices-the-new-role-of-hemodynamic-flow-indices-and-the-multi-modal-approach-to-the-rupture-risk-assessment-of-abdominal-aortic-aneurysms
#3
REVIEW
Nikolaos Kontopodis, Konstantinos Tzirakis, Christos V Ioannou
Although the therapeutic management of abdominal aortic aneurysms (AAAs) is currently based on the maximum diameter criterion, this has often proved inaccurate and misleading. Conversely, the biomechanical approach, which takes into account the pressure-induced wall stress exerted at every point throughout the aneurysmal surface, has been proven superior in predicting the rupture risk of AAAs, and its value is being increasingly recognized among physicians. More recently, hemodynamic indices, such as flow-induced wall shear stresses, have been indicated as potentially significant determinants of AAA natural history...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29681483/cyclization-of-plp-139-151-peptide-reduces-its-encephalitogenic-potential-in-experimental-autoimmune-encephalomyelitis
#4
Athanasios Lourbopoulos, Minos-Timotheos Matsoukas, Maria Katsara, George Deraos, Aggeliki Giannakopoulou, Roza Lagoudaki, Nikolaos Grigoriadis, John Matsoukas, Vasso Apostolopoulos
We report the novel synthesis of cyclic PLP139-151 (cPLP) and its application in SJL/J mice to study its encephalitogenic effects. Our results indicate that the cPLP analog is minimally encephalitogenic when administered to induce experimental autoimmune encephalomyelitis (low disease burden, minimal inflammatory, demyelinating and axonopathic pathology compared to its linear counterpart). Proliferation assays confirmed the low stimulatory potential of the cPLP compared to linPLP (2.5-fold lower proliferation) as well as inducing lower antibody responses...
December 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29680911/left-atrial-deformation-as-a-potent-predictor-for-paroxysmal-atrial-fibrillation-in-patients-with-end-stage-renal-disease
#5
Christodoulos E Papadopoulos, Efstathios Pagourelias, Constantinos Bakogiannis, Konstantinos Triantafyllou, Konstantinos Baltoumas, Efstratios Kassimatis, Dimitrios Zioutas, Dimitrios Siskos, Stergios Tzikas, Nikolaos Fragakis, Aikaterini Papagianni, Vassilios Vassilikos
It is widely known that various factors contribute to left atrial (LA) mechanical dysfunction in patients with end stage renal disease (ESRD). However, the connection between atrial dysfunction and arrhythmic events such as paroxysmal atrial fibrillation (PAF), in this group of patients, remains unclear. The purpose of our study was to evaluate prospectively the association between LA deformation indices and PAF in ESRD patients. 79 patients (41 men, mean age 57 ± 17) with ESRD and preserved left ventricular systolic function comprised the study population...
April 21, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29678613/a-3d-printed-bilayer-oral-solid-dosage-form-combining-metformin-for-prolonged-and-glimepiride-for-immediate-drug-delivery
#6
Christos I Gioumouxouzis, Apostolos Baklavaridis, Orestis L Katsamenis, Catherine K Markopoulou, Nikolaos Bouropoulos, Dimitrios Tzetzis, Dimitrios G Fatouros
Fused Deposition Modelling (a.k.a. FDM-3D printing) has been previously employed in the development of personalized medicines with unique properties and release behavior. In the present work, a bilayer dosage form containing two anti-diabetic drugs with different daily dosage regimens; i.e. metformin and glimepiride, was manufactured via FDM 3D printing, studied using a variety of techniques and characterized in vitro. Metformin and glimepiride were embedded in Eudragit® RL sustained release layer and polyvinyl alcohol (PVA) layer respectively...
April 17, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29676330/lacrimal-punctal-and-peripunctal-involvement-in-calcinosis-cutis
#7
Nandini Bothra, Mohammad Javed Ali, Nikolaos Trakos, Milind N Naik
Calcinosis cutis is a rare metabolic disorder characterized by cutaneous and subcutaneous deposition of insoluble calcium salts. Ocular adnexal involvement is uncommon but mostly seen in males and in the upper eyelid. Solitary lesions are more common than multiple. The treatment of choice is excision biopsy. Histopathological examination provides a definitive diagnosis. Directed systemic investigations help to rule out underlying pathologies and aids further management. The present case reports the punctal and peripunctal involvement in a case of ocular adnexal calcinosis cutis...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29674596/mfn2-agonists-reverse-mitochondrial-defects-in-preclinical-models-of-charcot-marie-tooth-disease-type-2a
#8
Agostinho G Rocha, Antonietta Franco, Andrzej M Krezel, Jeanne M Rumsey, Justin M Alberti, William C Knight, Nikolaos Biris, Emmanouil Zacharioudakis, James W Janetka, Robert H Baloh, Richard N Kitsis, Daria Mochly-Rosen, R Reid Townsend, Evripidis Gavathiotis, Gerald W Dorn
Mitofusins (MFNs) promote fusion-mediated mitochondrial content exchange and subcellular trafficking. Mutations in Mfn2 cause neurodegenerative Charcot-Marie-Tooth disease type 2A (CMT2A). We showed that MFN2 activity can be determined by Met376 and His380 interactions with Asp725 and Leu727 and controlled by PINK1 kinase-mediated phosphorylation of adjacent MFN2 Ser378 Small-molecule mimics of the peptide-peptide interface of MFN2 disrupted this interaction, allosterically activating MFN2 and promoting mitochondrial fusion...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29674283/controlled-deposition-of-fullerene-derivatives-within-a-graphene-template-by-means-of-a-modified-langmuir-schaefer-method
#9
Antonios Kouloumpis, Nikolaos Vourdas, Panagiota Zygouri, Nikolaos Chalmpes, Georgia Potsi, Vasilios Kostas, Konstantinos Spyrou, Vassilis N Stathopoulos, Dimitrios Gournis, Petra Rudolf
The scientific and technological potential of graphene's includes the development of light, open 3D hybrid structures with high surface area, tunable pore size and aromatic functionalities. Towards this aim, we describe a scalable and low-cost bottom-up approach that combines self-assembly and Langmuir-Schaefer deposition for the production of fullerene-intercalated graphene oxide hybrids. This method uses graphene oxide (GO) nanosheets as template for the attachment of two types of fullerene derivatives (bromo-fullerenes, C60 Br24 and fullerols, C60 (OH)24 ) in a bi-dimensional arrangement, allowing a layer-by-layer growth with control at nanoscale...
April 12, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29672386/strain-as-an-outcome-predictor
#10
Kimberly Howard-Quijano, Kan Zhang, Nikolaos J Skubas
No abstract text is available yet for this article.
May 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29671387/positioning-europe-for-the-epitranscriptomics-challenge
#11
Michael Jantsch, Alessandro Quattrone, Mary O'Connell, Mark Helm, Michaela Frye, Manuel Macias-Gonzales, Marie Ohman, Stefan Ameres, Luc Willems, Francois Fuks, Anastasis Oulas, Stepanka Vanacova, Henrik Nielsen, Cecile Bousquet-Antonelli, Yuri Motorin, Jean-Yves Roignant, Nikolaos Balatsos, Andras Dinnyes, Pavel Baranov, Vincent Kelly, Ayelet Lamm, Gideon Rechavi, Mattia Pelizzola, Janis Liepins, Irina Holodnuka Kholodnyuk, Vanessa Zammit, Duncan Ayers, Finn Drablos, John Arne Dahl, Janusz Bujnicki, Carmen Jeronimo, Raquel Almeida, Monica Neagu, Marieta Costache, Jasna Bankovic, Bojana Banovic, Jan Kyselovic, Luis Miguel Valor, Stefan Selbert, Pinar Pir, Turan Demircan, Victoria Cowling, Matthias Schäfer, Walter Rossmanith, Denis Lafontaine, Alexandre David, Clement Carre, Frank Lyko, Raffael Schaffrath, Schraga Schwartz, Andre Verdel, Arne Klungland, Elzbieta Purta, Gordana Timotijevic, Fernando Cardona, Alberto Davalos, Ester Ballana, Donal O Carroll, Jernej Ule, Rupert Fray
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research...
April 19, 2018: RNA Biology
https://www.readbyqxmd.com/read/29670652/combined-dorsal-and-ventral-onlay-buccal-graft-technique-for-large-and-complex-penile-strictures
#12
Nikolaos Mertziotis, Andreas Konandreas, Christos Kyratsas
Purpose: To present a modified technique of managing extensive penile urethral strictures with dorsal and ventral onlay buccal mucosa grafts. Patients and Methods: From October 2014 to January 2016, a total of 12 patients underwent urethroplasty for penile urethral strictures, using dorsal and ventral onlay grafts from buccal mucosa. The mean age was 42.75 (17-71). All patients completed the IPSS and QoL questionnaire, and uroflowmetry was done preoperatively. After surgery, the follow-up included completion of IPSS and QoL questionnaire and measuring of uroflow at 1, 3, 6, and 12 months...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29667916/fiscal-impact-of-smoking-cessation-in-thailand-a-government-perspective-cost-benefit-analysis
#13
Mark P Connolly, Nikolaos Kotsopoulos, Pichaya Suthipinijtham, Suthat Rungruanghiranya
We evaluate the broader public economic consequences of investments in smoking cessation that change lifetime productivity, which can influence future government tax revenue and social transfer costs and health care spending. The analysis applies a government perspective framework for assessing the intergenerational relationships between morbidity and mortality and lifetime tax revenue and social transfers received. Applying smoking prevalence in Thailand, a cohort model was developed for smoker and former smokers to estimate impact on lifetime direct taxes and tobacco taxes paid...
April 1, 2018: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29666816/surgical-approach-in-oligometastatic-non-small-cell-lung-cancer
#14
REVIEW
Davide Patrini, Nikolaos Panagiotopoulos, Benedetta Bedetti, Sofoklis Mitsos, Roberto Crisci, Piergiorgio Solli, Luca Bertolaccini, Marco Scarci
The vast majority of lung cancer (80%) are non-small cell lung cancer (NSCLC) presenting in huge proportion of patients in a metastatic stage at the time of diagnosis with an overall survival (OS) of only 6 months. Standard treatment at this stage involves systemic platinum based chemotherapy improving the OS for only few months. For the vast majority of patients disease progression occurs and cure cannot achieved. An exception to this general rule is represented by patients with a limited number of metastasis (approximately 7% of patients with metastatic NSCLC): in 1995 Hellman and Weichselbaum introduced the term "oligometastatic" for a selected group of patients with metastatic disease...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29664935/correction-diffusion-weighted-imaging-in-patients-with-rectal-cancer-comparison-between-gaussian-and-non-gaussian-models
#15
Georgios C Manikis, Kostas Marias, Doenja M J Lambregts, Katerina Nikiforaki, Miriam M van Heeswijk, Frans C H Bakers, Regina G H Beets-Tan, Nikolaos Papanikolaou
[This corrects the article DOI: 10.1371/journal.pone.0184197.].
2018: PloS One
https://www.readbyqxmd.com/read/29663912/periodontal-impact-of-preformed-metal-crowns-on-permanent-molars-of-children-and-adolescents-a-pilot-study
#16
Aikaterini Koleventi, Dimitra Sakellari, Konstantinos N Arapostathis, Nikolaos Kotsanos
PURPOSE: When treating an early permanent molar with coronal malformation in children, as in severe molar incisor hypomineralization (MIH) cases, preformed metal crowns (PMCs) are a successful mid- to long-term restorative option. The purpose of this study was to evaluate possible changes in periodontal tissues and subgingival microbiota after PMC placement by way of a split-mouth study. METHODS: Fourteen healthy patients with a mean age of 10.6 (±4.2) years old, attending a university dental clinic, had one MIH severely affected permanent first molar restored with a PMC (study side), while the contralateral relatively healthy tooth was the control...
March 15, 2018: Pediatric Dentistry
https://www.readbyqxmd.com/read/29659092/diffusion-tensor-imaging-parameters-in-testes-with-nonobstructive-azoospermia
#17
Athina C Tsili, Alexandra Ntorkou, Anna Goussia, Loukas Astrakas, Eleni Panopoulou, Nikolaos Sofikitis, Maria I Argyropoulou
BACKGROUND: The development of noninvasive imaging parameters having the capacity to identify the population of men with nonobstructive azoospermia (NOA) where a successful sperm retrieval outcome is of great clinical significance. PURPOSE/HYPOTHESIS: To assess differences of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in NOA testes with impaired spermatogenesis and the possible association with the presence of spermatozoa after testicular sperm extraction (TESE)...
April 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29657586/european-heart-rhythm-association-ehra-heart-rhythm-society-hrs-asia-pacific-heart-rhythm-society-aphrs-latin-american-heart-rhythm-society-lahrs-expert-consensus-on-arrhythmias-and-cognitive-function-what-is-the-best-practice
#18
Nikolaos Dagres, Tze-Fan Chao, Guilherme Fenelon, Luis Aguinaga, Daniel Benhayon, Emelia J Benjamin, T Jared Bunch, Lin Yee Chen, Shih-Ann Chen, Francisco Darrieux, Angelo de Paola, Laurent Fauchier, Andreas Goette, Jonathan Kalman, Lalit Kalra, Young-Hoon Kim, Deirdre A Lane, Gregory Y H Lip, Steven A Lubitz, Manlio F Márquez, Tatjana Potpara, Domingo Luis Pozzer, Jeremy N Ruskin, Irina Savelieva, Wee Siong Teo, Hung-Fat Tse, Atul Verma, Shu Zhang, Mina K Chung, William-Fernando Bautista-Vargas, Chern-En Chiang, Alejandro Cuesta, Gheorghe-Andrei Dan, David S Frankel, Yutao Guo, Robert Hatala, Young Soo Lee, Yuji Murakawa, Cara N Pellegrini, Claudio Pinho, David J Milan, Daniel P Morin, Elenir Nadalin, George Ntaios, Mukund A Prabhu, Marco Proietti, Lena Rivard, Mariana Valentino, Alena Shantsila
No abstract text is available yet for this article.
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29656550/mir-181c-brk1-axis-plays-a-key-role-in-actin-cytoskeleton-dependent-t-cell-function
#19
Shok Ping Lim, Nikolaos Ioannou, Alan G Ramsay, David Darling, Joop Gäken, Ghulam J Mufti
MicroRNAs are short endogenous noncoding RNAs that play pivotal roles in a diverse range of cellular processes. The miR-181 family is important in T cell development, proliferation, and activation. In this study, we have identified BRK1 as a potential target of miR-181c using a dual selection functional assay and have showed that miR-181c regulates BRK1 by translational inhibition. Given the importance of miR-181 in T cell function and the potential role of BRK1 in the involvement of WAVE2 complex and actin polymerization in T cells, we therefore investigated the influence of miR-181c-BRK1 axis in T cell function...
April 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29656291/activin-a-is-a-pro-inflammatory-regulator-in-type-2-driven-upper-airway-disease
#20
Adam M Chaker, Ulrich Matthias Zissler, Nikolaos Poulos, Martin Wagenmann, Murat Bas, Ferdinand Gürth, Georgina Xanthou, Carsten Schmidt-Weber
BACKGROUND: Allergic upper airway disease involves pro-inflammatory type-2 cytokines such as IL-5 and regulatory tissue repair mediators, in particular transforming growth factor (TGF)-β1. The TGF-β-superfamily member activin-A displays multiple biological functions and shares certain signalling pathways with TGF-β1. We aimed to examine the coregulation of mucosal activin-A and TGF-β1 in acute allergic and chronic Th2-driven upper airway disease. METHODS: We investigated mucosal cytokine expression profiles and kinetics using RT-PCR after nasal allergen challenges in patients with seasonal allergic rhinitis...
April 13, 2018: International Archives of Allergy and Immunology
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