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https://www.readbyqxmd.com/read/28222661/an-industry-update-what-are-the-latest-developments-in-the-field-of-therapeutic-delivery-industry-update-1st-december-to-31st-december-2016
#1
Peter Timmins
No abstract text is available yet for this article.
April 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28204992/the-life-experience-of-nutrition-impact-symptoms-during-treatment-for-head-and-neck-cancer-patients-a-systematic-review-and-meta-synthesis
#2
REVIEW
Valentina Bressan, Annamaria Bagnasco, Giuseppe Aleo, Gianluca Catania, Milko P Zanini, Fiona Timmins, Loredana Sasso
PURPOSE: In the literature, there is limited research about the changed meaning of food, the eating and the eating experience during treatment in patients with head and neck cancer. This systematic review includes findings from a qualitative research synthesis to gain a deeper understanding of the influence and experiences of dysphagia, dysgeusia, oral mucositis and xerostomia in head and neck cancer patients (HNC) and suggests recommendations for care practice. METHOD: A systematic review and meta-synthesis techniques were adopted to identify, appraise and synthesize the relevant literature regarding the experience of nutritional symptoms of HNC patients conducted according to the PRISMA guidelines...
February 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28176591/promoting-healthy-lifestyle-behaviours-and-well-being-among-nursing-students
#3
Patsy McSharry, Fiona Timmins
First-year university students often embark on university life with excitement. In addition to experiencing greater freedom, they begin to take responsibility for their lives. However, it can be challenging for students to balance their studies with their new self-care responsibilities, while forming peer relationships. Some students may eat a suboptimal diet, for example they may regularly consume 'fast food' rather than healthier alternatives. Their physical activity may also decrease, as a result of time constraints and/or lifestyle choices...
February 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28148771/oscillatory-wall-shear-stress-is-a-dominant-flow-characteristic-affecting-lesion-progression-patterns-and-plaque-vulnerability-in-patients-with-coronary-artery-disease
#4
Lucas H Timmins, David S Molony, Parham Eshtehardi, Michael C McDaniel, John N Oshinski, Don P Giddens, Habib Samady
Although experimental studies suggest that low and oscillatory wall shear stress (WSS) promotes plaque transformation to a more vulnerable phenotype, this relationship has not been examined in human atherosclerosis progression. Thus, the aim of this investigation was to examine the association between oscillatory WSS, in combination with WSS magnitude, and coronary atherosclerosis progression. We hypothesized that regions of low and oscillatory WSS will demonstrate progression towards more vulnerable lesions, while regions exposed to low and non-oscillatory WSS will exhibit progression towards more stable lesions...
February 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28130368/commentary-on-goodacre-r-timmins-%C3%A3-m-rooney-pj-rowland-jj-kell-db-rapid-identification-of-streptococcus-and-enterococcus-species-using-diffuse-reflectance-absorbance-fourier-transform-infrared-spectroscopy-and-artificial-neural-networks-fems-microbiol-lett
#5
Royston Goodacre, Douglas B Kell
This is an invited review/commentary by the first and last authors of a paper that was the most cited in FEMS Microbiology Letters for 1996, presently showing in excess of 150 citations at Web of Science, and over 200 at Google Scholar. It was the first paper in which diffuse-reflectance-absorbance FT-IR spectroscopy was used with a supervised learning method in the form of artificial neural networks, and showed that this combination could succeed in discriminating a series of closely related, clinically relevant, Gram-positive bacterial strains...
January 26, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28122497/phylogeography-of-red-muntjacs-reveals-three-distinct-mitochondrial-lineages
#6
Renata F Martins, Jörns Fickel, Minh Le, Thanh van Nguyen, Ha M Nguyen, Robert Timmins, Han Ming Gan, Jeffrine J Rovie-Ryan, Dorina Lenz, Daniel W Förster, Andreas Wilting
BACKGROUND: The members of the genus Muntiacus are of particular interest to evolutionary biologists due to their extreme chromosomal rearrangements and the ongoing discussions about the number of living species. Red muntjacs have the largest distribution of all muntjacs and were formerly considered as one species. Karyotype differences led to the provisional split between the Southern Red Muntjac (Muntiacus muntjak) and the Northern Red Muntjac (M. vaginalis), but uncertainties remain as, so far, no phylogenetic study has been conducted...
January 26, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28120672/understanding-spirituality-and-spiritual-care-in-nursing
#7
Fiona Timmins, Sílvia Caldeira
Spirituality is a complex concept that has different meanings for different people. Spiritual care is a fundamental aspect of nursing and attending to the spiritual needs of patients may improve their health outcomes. This article, the first in a series of three, explores various definitions of spirituality, and the importance of spirituality and spiritual care in healthcare settings. The second article of this series provides an in-depth exploration of the assessment of patients' spiritual care needs, and the third and final article in this short series discusses spiritual care nursing interventions...
January 25, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28106415/charge-dependent-directed-flow-in-cu-au-collisions-at-sqrt-s_-nn-200%C3%A2-%C3%A2-gev
#8
L Adamczyk, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, I Alekseev, D M Anderson, R Aoyama, A Aparin, D Arkhipkin, E C Aschenauer, M U Ashraf, A Attri, G S Averichev, X Bai, V Bairathi, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, J D Brandenburg, A V Brandin, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, I Chakaberia, P Chaloupka, Z Chang, A Chatterjee, S Chattopadhyay, X Chen, J H Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, R R Debbe, T G Dedovich, J Deng, A A Derevschikov, B di Ruzza, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, C M Du, L E Dunkelberger, J C Dunlop, L G Efimov, J Engelage, G Eppley, R Esha, S Esumi, O Evdokimov, O Eyser, R Fatemi, S Fazio, P Federic, J Fedorisin, Z Feng, P Filip, E Finch, Y Fisyak, C E Flores, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, L Greiner, D Grosnick, D S Gunarathne, Y Guo, S Gupta, A Gupta, W Guryn, A I Hamad, A Hamed, R Haque, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, G W Hoffmann, S Horvat, B Huang, X Huang, H Z Huang, T Huang, P Huck, T J Humanic, G Igo, W W Jacobs, A Jentsch, J Jia, K Jiang, S Jowzaee, E G Judd, S Kabana, D Kalinkin, K Kang, K Kauder, H W Ke, D Keane, A Kechechyan, Z H Khan, D P Kikoła, I Kisel, A Kisiel, L Kochenda, D D Koetke, L K Kosarzewski, A F Kraishan, P Kravtsov, K Krueger, L Kumar, M A C Lamont, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, Y Li, C Li, W Li, X Li, X Li, T Lin, M A Lisa, Y Liu, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, X Luo, S Luo, G L Ma, R Ma, Y G Ma, L Ma, N Magdy, R Majka, A Manion, S Margetis, C Markert, H S Matis, D McDonald, S McKinzie, K Meehan, J C Mei, Z W Miller, N G Minaev, S Mioduszewski, D Mishra, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, B K Nandi, Md Nasim, T K Nayak, G Nigmatkulov, T Niida, L V Nogach, T Nonaka, J Novak, S B Nurushev, G Odyniec, A Ogawa, K Oh, V A Okorokov, D Olvitt, B S Page, R Pak, Y X Pan, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, P Pile, J Pluta, K Poniatowska, J Porter, M Posik, A M Poskanzer, N K Pruthi, M Przybycien, J Putschke, H Qiu, A Quintero, S Ramachandran, R L Ray, R Reed, M J Rehbein, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, J D Roth, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, I Sakrejda, S Salur, J Sandweiss, A Sarkar, J Schambach, R P Scharenberg, A M Schmah, W B Schmidke, N Schmitz, J Seger, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, A Sharma, M K Sharma, B Sharma, W Q Shen, S S Shi, Z Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, D Smirnov, N Smirnov, W Solyst, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Stepanov, R Stock, M Strikhanov, B Stringfellow, T Sugiura, M Sumbera, B Summa, Z Sun, Y Sun, X M Sun, B Surrow, D N Svirida, A H Tang, Z Tang, T Tarnowsky, A Tawfik, J Thäder, J H Thomas, A R Timmins, D Tlusty, T Todoroki, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, R Varma, A N Vasiliev, R Vertesi, F Videbæk, S Vokal, S A Voloshin, A Vossen, G Wang, F Wang, J S Wang, Y Wang, H Wang, Y Wang, J C Webb, G Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y Wu, Z G Xiao, W Xie, G Xie, K Xin, Q H Xu, Y F Xu, H Xu, Z Xu, N Xu, J Xu, C Yang, Y Yang, S Yang, Y Yang, Q Yang, Y Yang, Z Ye, Z Ye, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, J Zhang, X P Zhang, S Zhang, Y Zhang, J B Zhang, Z Zhang, S Zhang, J Zhang, J Zhao, C Zhong, L Zhou, X Zhu, Y Zoulkarneeva, M Zyzak
We present the first measurement of charge-dependent directed flow in Cu+Au collisions at sqrt[s_{NN}]=200  GeV. The results are presented as a function of the particle transverse momentum and pseudorapidity for different centralities. A finite difference between the directed flow of positive and negative charged particles is observed that qualitatively agrees with the expectations from the effects of the initial strong electric field between two colliding ions with different nuclear charges. The measured difference in directed flow is much smaller than that obtained from the parton-hadron-string-dynamics model, which suggests that most of the electric charges, i...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28102449/development-of-a-new-assessment-tool-for-cervical-myelopathy-using-hand-tracking-sensor-part-2-normative-values
#9
M Abdulhadi Alagha, Mahmoud A Alagha, Eleanor Dunstan, Olaf Sperwer, Kate A Timmins, Bronek M Boszczyk
PURPOSE: To set a baseline measurement of the number of hand flexion-extension cycles and analyse the degree of motion in young healthy individuals, measured by leap motion controller (LMC), besides describing gender and dominant hand differences. METHODS: Fifty healthy participants were asked to fully grip-and-release their dominant hand as rapidly as possible for a maximum of 3 min or until subjects fatigued, while wearing a non-metal wrist splint. Participants also performed a 15-s grip-and-release test...
January 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28102448/development-of-a-new-assessment-tool-for-cervical-myelopathy-using-hand-tracking-sensor-part-1-validity-and-reliability
#10
M Abdulhadi Alagha, Mahmoud A Alagha, Eleanor Dunstan, Olaf Sperwer, Kate A Timmins, Bronek M Boszczyk
PURPOSE: To assess the reliability and validity of a hand motion sensor, Leap Motion Controller (LMC), in the 15-s hand grip-and-release test, as compared against human inspection of an external digital camera recording. METHODS: Fifty healthy participants were asked to fully grip-and-release their dominant hand as rapidly as possible for two trials with a 10-min rest in-between, while wearing a non-metal wrist splint. Each test lasted for 15 s, and a digital camera was used to film the anterolateral side of the hand on the first test...
January 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28068097/characterization-of-phase-separation-propensity-for-amorphous-spray-dried-dispersions
#11
Daniel McNamara, Shawn Yin, Duohai Pan, George Crull, Peter Timmins, Balvinder Vig
A generalized screening approach, applying isothermal calorimetry at 37 °C 100% RH, to formulations of spray dried dispersions (SDDs) for two active pharmaceutical ingredients (APIs) (BMS-903452 and BMS-986034) is demonstrated. APIs 452 and 034, with similar chemotypes, were synthesized and promoted during development for oral dosing. Both APIs were formulated as SDDs for animal exposure studies using the polymer hydroxypropylmethlycellulose acetyl succinate M grade (HPMCAS-M). 452 formulated at 30% (wt/wt %) was an extremely robust SDD that was able to withstand 40 °C 75% RH open storage conditions for 6 months with no physical evidence of crystallization or loss of dissolution performance...
January 20, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28061350/achieving-efficient-manufacturing-and-quality-assurance-through-synthetic-cell-therapy-design
#12
Yonatan Y Lipsitz, Patrick Bedford, Anthony H Davies, Nicholas E Timmins, Peter W Zandstra
New methods to manipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment, and enhance manufacturability. These strategies could help overcome unresolved cell therapy manufacturing challenges and complement frameworks to design quality into these complex cellular systems, ultimately increasing patient access to living therapeutics.
January 5, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28035586/criteria-for-progressing-rehabilitation-and-determining-return-to-play-clearance-following-hamstring-strain-injury-a-systematic-review
#13
REVIEW
Jack T Hickey, Ryan G Timmins, Nirav Maniar, Morgan D Williams, David A Opar
BACKGROUND: Rehabilitation progression and return-to-play (RTP) decision making following hamstring strain injury (HSI) can be challenging for clinicians, owing to the competing demands of reducing both convalescence and the risk of re-injury. Despite an increased focus on the RTP process following HSI, little attention has been paid to rehabilitation progression and RTP criteria, and subsequent time taken to RTP and re-injury rates. OBJECTIVE: The aim of this systematic review is to identify rehabilitation progression and RTP criteria implemented following HSI and examine the subsequent time taken to RTP and rates of re-injury...
December 29, 2016: Sports Medicine
https://www.readbyqxmd.com/read/28029705/cardiometabolic-health-and-risk-of-amyotrophic-lateral-sclerosis
#14
Hannah C Timmins, Wilfred Saw, Benjamin C Cheah, Cindy S Y Lin, Steve Vucic, Rebekah M Ahmed, Matthew C Kiernan, Susanna B Park
INTRODUCTION: Patients diagnosed with amyotrophic lateral sclerosis (ALS) generally have a limited medical history and a normal body mass index, raising the possibility of a premorbid ALS phenotype. METHODS: The prevalence of cardiometabolic factors was analyzed in 58 ALS patients via comprehensive cardiovascular assessments and compared to Australian population norms. RESULTS: ALS patients had good cardiac fitness and no reported cardiovascular events...
December 28, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27941158/the-experience-of-spirituality-from-the-perspective-of-people-living-with-dementia-a-systematic-review-and-meta-synthesis
#15
Louise Daly, Elizabeth Fahey-McCarthy, Fiona Timmins
Spirituality is an important aspect of humanity. Concerned with deriving meaning from events, and connection with others, it provides a mechanism for some to cope with illness and disability. While spiritual support is recognised as important, little is known about the spiritual needs of those people experiencing dementia. This meta-synthesis considers the experiences of spirituality from the perspective of people living with a diagnosis of dementia. Using a review protocol, key words from a preliminary scoping review were used to direct database searches in November 2013...
December 9, 2016: Dementia
https://www.readbyqxmd.com/read/27924191/a-decade-of-biochemical-and-structural-studies-of-the-dna-repair-machinery-of-deinococcus-radiodurans-major-findings-functional-and-mechanistic-insight-and-challenges
#16
REVIEW
Joanna Timmins, Elin Moe
No abstract text is available yet for this article.
2016: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/27890076/dirofilaria-immitis-exhibits-sex-and-stage-specific-differences-in-excretory-secretory-mirna-and-protein-profiles
#17
Lucienne Tritten, Damian Clarke, Scott Timmins, Tom McTier, Timothy G Geary
The canine heartworm Dirofilaria immitis releases excretory/secretory molecules into its host and in culture. We report analyses of the types, amounts and stage-dependence of microRNAs and proteins found in D. immitis culture media recovered after incubating 800,000 microfilariae for 6days, 500L3 and 500L4 for 7days, as well as 40 adult females and 40 adult males for 48h, all separately. In addition, the presence of exosome-like particles was established by nanoparticle tracking analysis. Our results are in concordance with the D...
December 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27888211/biceps-femoris-architecture-the-association-with-injury-and-response-to-training
#18
Ryan Timmins
No abstract text is available yet for this article.
November 25, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27884865/running-exposure-is-associated-with-the-risk-of-hamstring-strain-injury-in-elite-australian-footballers
#19
Joshua D Ruddy, Christopher W Pollard, Ryan G Timmins, Morgan D Williams, Anthony J Shield, David A Opar
BACKGROUND: To investigate the association between running exposure and the risk of hamstring strain injury (HSI) in elite Australian footballers. METHODS: Elite Australian footballers (n=220) from 5 different teams participated. Global positioning system (GPS) data were provided for every athlete for each training session and match for the entire 2015 season. The occurrences of HSIs throughout the study period were reported. Receiver operator characteristic curve analyses were performed and the relative risk (RR) of subsequent HSI was calculated for absolute and relative running exposure variables related to distance covered above 10 and 24 km/hour in the preceding week/s...
November 24, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27875743/from-the-struggle-of-defining-to-the-understanding-of-dignity-a-commentary-on-barclay-2016-in-sickness-and-in-dignity-a-philosophical-account-of-the-meaning-of-dignity-in-health-care
#20
Sílvia Caldeira, Margarida Vieira, Fiona Timmins, Wilfred McSherry
No abstract text is available yet for this article.
November 16, 2016: International Journal of Nursing Studies
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