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https://www.readbyqxmd.com/read/27920567/evaluation-of-bode-index-and-its-relationship-with-systemic-inflammation-mediated-by-proinflammatory-biomarkers-in-patients-with-copd
#1
Naushad Ahmad Khan, Mradul Kumar Daga, Istaq Ahmad, Govind Mawari, Suman Kumar, Naresh Kumar, Syed Akhter Husain
INTRODUCTION: BODE index, a multidimensional grading system which is based on Body mass index, airway Obstruction, Dyspnea scale, and Exercise capacity, has been increasingly used for the evaluation of chronic obstructive pulmonary disease (COPD). Many of the systemic manifestations of COPD are shown to be mediated by elevated levels of proinflammatory biomarkers. OBJECTIVE: We aimed to investigate the relationship between the BODE index, its components, disease severity, and proinflammatory biomarkers like C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27864677/glucocorticoids
#2
Ian M Adcock, Sharon Mumby
The most effective anti-inflammatory drugs used to treat patients with airways disease are topical glucocorticosteroids (GCs). These act on virtually all cells within the airway to suppress airway inflammation or prevent the recruitment of inflammatory cells into the airway. They also have profound effects on airway structural cells to reverse the effects of disease on their function. Glucorticosteroids act via specific receptors-the glucocorticosteroid receptor (GR)-which are a member of the nuclear receptor family...
November 19, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27842498/least-absolute-shrinkage-and-selection-operator-type-methods-for-the-identification-of-serum-biomarkers-of-overweight-and-obesity-simulation-and-application
#3
Monica M Vasquez, Chengcheng Hu, Denise J Roe, Zhao Chen, Marilyn Halonen, Stefano Guerra
BACKGROUND: The study of circulating biomarkers and their association with disease outcomes has become progressively complex due to advances in the measurement of these biomarkers through multiplex technologies. The Least Absolute Shrinkage and Selection Operator (LASSO) is a data analysis method that may be utilized for biomarker selection in these high dimensional data. However, it is unclear which LASSO-type method is preferable when considering data scenarios that may be present in serum biomarker research, such as high correlation between biomarkers, weak associations with the outcome, and sparse number of true signals...
November 14, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27831562/mitochondrial-transfer-of-mesenchymal-stem-cells-effectively-protects-corneal-epithelial-cells-from-mitochondrial-damage
#4
Dan Jiang, Fei Gao, Yuelin Zhang, David Sai Hung Wong, Qing Li, Hung-Fat Tse, Goufeng Xu, Zhendong Yu, Qizhou Lian
Recent studies have demonstrated that mesenchymal stem cells (MSCs) can donate mitochondria to airway epithelial cells and rescue mitochondrial damage in lung injury. We sought to determine whether MSCs could donate mitochondria and protect against oxidative stress-induced mitochondrial dysfunction in the cornea. Co-culturing of MSCs and corneal epithelial cells (CECs) indicated that the efficiency of mitochondrial transfer from MSCs to CECs was enhanced by Rotenone (Rot)-induced oxidative stress. The efficient mitochondrial transfer was associated with increased formation of tunneling nanotubes (TNTs) between MSCs and CECs, tubular connections that allowed direct intercellular communication...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27801552/th17-responses-to-col-v-k%C3%AE-1-tubulin-and-vimentin-are-present-early-in-human-development-and-persist-lifelong
#5
Jeremy A Sullivan, Ewa Jankowska-Gan, Subramanya Hegde, Matthew A Pestrak, Vrushali V Agashe, Arick C Park, Matthew E Brown, John F Kernien, David S Wilkes, Dixon B Kaufman, Daniel S Greenspan, William J Burlingham
Th17-dependent autoimmune responses can develop after heart or lung transplantation, and are associated with fibro-obliterative forms of chronic rejection. However, the specific self-antigens involved are typically different from those associated with autoimmune disease. To investigate the basis of these responses, we questioned whether removal of Tregs or blockade of function reveals a similar auto-antigen bias. We found that Th17 cells specific for collagen type V (Col V), kα-1-tubulin, and vimentin were present in healthy, adult PBMC, cord blood, and fetal thymus...
November 1, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27777975/the-role-for-neutrophil-extracellular-traps-in-cystic-fibrosis-autoimmunity
#6
Sladjana Skopelja, B JoNell Hamilton, Jonathan D Jones, Mei-Ling Yang, Mark Mamula, Alix Ashare, Alex H Gifford, William F C Rigby
While respiratory failure in cystic fibrosis (CF) frequently associates with chronic infection by Pseudomonas aeruginosa, no single factor predicts the extent of lung damage in CF. To elucidate other causes, we studied the autoantibody profile in CF and rheumatoid arthritis (RA) patients, given the similar association of airway inflammation and autoimmunity in RA. Even though we observed that bactericidal permeability-increasing protein (BPI), carbamylated proteins, and citrullinated proteins all localized to the neutrophil extracellular traps (NETs), which are implicated in the development of autoimmunity, our study demonstrates striking autoantibody specificity in CF...
October 20, 2016: JCI Insight
https://www.readbyqxmd.com/read/27776186/serum-reactive-oxygen-metabolite-levels-predict-severe-exacerbations-of-asthma
#7
Keitaro Nakamoto, Masato Watanabe, Mitsuru Sada, Toshiya Inui, Masuo Nakamura, Kojiro Honda, Hiroo Wada, Yu Mikami, Hirotaka Matsuzaki, Masafumi Horie, Satoshi Noguchi, Yasuhiro Yamauchi, Hikari Koyama, Toshiyuki Kogane, Tadashi Kohyama, Hajime Takizawa
BACKGROUND AND PURPOSE: Bronchial asthma (BA) is a chronic airway disease characterized by airway hyperresponsiveness and remodeling, which are intimately linked to chronic airway inflammation. Reactive oxygen species (ROS) such as hydrogen peroxide are generated by inflammatory cells that are involved in the pathogenesis of BA. However, the role of ROS in the management of BA patients is not yet clear. We attempted to determine the role of ROS as a biomarker in the clinical setting of BA...
2016: PloS One
https://www.readbyqxmd.com/read/27746262/caffeic-acid-phenethyl-ester-alleviates-asthma-by-regulating-the-airway-microenvironment-via-the-ros-responsive-mapk-akt-pathway
#8
REVIEW
Yuan Ma, Jia-Xiang Zhang, Ya-Nan Liu, Ai Ge, Hao Gu, Wang-Jian Zha, Xiao-Ning Zeng, Mao Huang
In the pathophysiology of asthma, structural cell dysfunction and concomitant microenvironment changes in airways are crucial to pathological progression, which involves oxidative stress. Caffeic acid phenethyl ester (CAPE) is an active anti-oxidative component obtained from propolis, and has been shown to have beneficial effects on several respiratory disorders, such as chronic obstructive pulmonary disease and lung cancer. However, the impact of CAPE on asthma is not well understood. Therefore, this study investigated the advantages of using CAPE to treat asthma and demonstrated the roles of CAPE in the regulation of airway microenvironments...
October 13, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27741074/using-pleth-variability-as-a-triage-tool-for-children-with-obstructive-airway-disease-in-a-pediatric-emergency-department
#9
Ariel Brandwein, Kavita Patel, Myriam Kline, Peter Silver, Sandeep Gangadharan
OBJECTIVES: Patients with obstructive airway disease have varying degrees of pulsus paradoxus that correlate with illness severity. Pulsus paradoxus can be measured using plethysmography. We investigated whether plethysmograph (pleth) variability on admission to the pediatric emergency department (ED) could predict patient disposition. We hypothesized that patients with a larger pleth variability would have a higher likelihood of being admitted to a general pediatrics unit or the intensive care unit (ICU)...
October 6, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27716343/high-levels-of-biomarkers-of-collagen-remodeling-are-associated-with-increased-mortality-in-copd-results-from-the-eclipse-study
#10
Jannie M B Sand, Diana J Leeming, Inger Byrjalsen, Asger R Bihlet, Peter Lange, Ruth Tal-Singer, Bruce E Miller, Morten A Karsdal, Jørgen Vestbo
BACKGROUND: There is a need to identify individuals with COPD at risk for disease progression and mortality. Lung tissue remodeling is associated with the release of extracellular matrix (ECM) fragments into the peripheral circulation. We hypothesized that ECM remodeling was associated with mortality in COPD and measured neo-epitopes originating from ECM proteins associated with lung tissue remodeling. METHODS: Biomarkers of ECM remodeling were assessed in a subpopulation (n = 1000) of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) cohort...
October 4, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27713627/elevated-circulating-pai-1-levels-are-related-to-lung-function-decline-systemic-inflammation-and-small-airway-obstruction-in-chronic-obstructive-pulmonary-disease
#11
Hao Wang, Ting Yang, Diandian Li, Yanqiu Wu, Xue Zhang, Caishuang Pang, Junlong Zhang, Binwu Ying, Tao Wang, Fuqiang Wen
BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) and soluble urokinase-type plasminogen activator receptor (suPAR) participate in inflammation and tissue remolding in various diseases, but their roles in chronic obstructive pulmonary disease (COPD) are not yet clear. This study aimed to investigate if PAI-1 and suPAR were involved in systemic inflammation and small airway obstruction (SAO) in COPD. METHODS: Demographic and clinical characteristics, spirometry examination, and blood samples were obtained from 84 COPD patients and 51 healthy volunteers...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27695125/synthesis-pharmacological-profile-and-docking-studies-of-new-sulfonamides-designed-as-phosphodiesterase-4-inhibitors
#12
Isabelle Karine da Costa Nunes, Everton Tenório de Souza, Suzana Vanessa S Cardozo, Vinicius de Frias Carvalho, Nelilma Correia Romeiro, Patrícia Machado Rodrigues E Silva, Marco Aurélio Martins, Eliezer J Barreiro, Lídia Moreira Lima
Prior investigations showed that increased levels of cyclic AMP down-regulate lung inflammatory changes, stimulating the interest in phosphodiesterase (PDE)4 as therapeutic target. Here, we described the synthesis, pharmacological profile and docking properties of a novel sulfonamide series (5 and 6a-k) designed as PDE4 inhibitors. Compounds were screened for their selectivity against the four isoforms of human PDE4 using an IMAP fluorescence polarized protocol. The effect on allergen- or LPS-induced lung inflammation and airway hyper-reactivity (AHR) was studied in A/J mice, while the xylazine/ketamine-induced anesthesia test was employed as a behavioral correlate of emesis in rodents...
2016: PloS One
https://www.readbyqxmd.com/read/27693879/serum-from-obstructive-sleep-apnea-patients-induces-inflammatory-responses-in-coronary-artery-endothelial-cells
#13
Katherine E Zychowski, Bethany Sanchez, Rodrigo P Pedrosa, Geraldo Lorenzi-Filho, Luciano F Drager, Vsevolod Y Polotsky, Matthew J Campen
BACKGROUND AND AIMS: Obstructive sleep apnea (OSA) is characterized by intermittent airway obstruction and systemic hypoxia during sleep, which can contribute to an increase in reactive oxygen species, vascular remodeling, vasoconstriction and ultimately cardiovascular disease. Continuous positive airway pressure (CPAP) is a clinical therapy that maintains airway patency and mitigates several symptoms of OSA. However, it is currently unknown whether CPAP therapy also reduces the overall inflammatory potential in the circulation; to address this in an unbiased manner, we applied a novel endothelial biosensor approach, the serum cumulative inflammatory potential (SCIP) assay...
November 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27684886/local-mosquito-borne-transmission-of-zika-virus-miami-dade-and-broward-counties-florida-june-august-2016
#14
Anna Likos, Isabel Griffin, Andrea M Bingham, Danielle Stanek, Marc Fischer, Stephen White, Janet Hamilton, Leah Eisenstein, David Atrubin, Prakash Mulay, Blake Scott, Patrick Jenkins, Danielle Fernandez, Edhelene Rico, Leah Gillis, Reynald Jean, Marshall Cone, Carina Blackmore, Janet McAllister, Chalmers Vasquez, Lillian Rivera, Celeste Philip
During the first 6 months of 2016, large outbreaks of Zika virus disease caused by local mosquito-borne transmission occurred in Puerto Rico and other U.S. territories, but local mosquito-borne transmission was not identified in the continental United States (1,2). As of July 22, 2016, the Florida Department of Health had identified 321 Zika virus disease cases among Florida residents and visitors, all occurring in either travelers from other countries or territories with ongoing Zika virus transmission or sexual contacts of recent travelers...
2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27680676/cigarette-smoke-reversibly-activates-hypoxia-inducible-factor-1-in-a-reactive-oxygen-species-dependent-manner
#15
Hiroki Daijo, Yuma Hoshino, Shinichi Kai, Kengo Suzuki, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Kiichi Hirota
Cigarette smoke (CS) is a major contributor to the development of a large number of fatal and debilitating disorders. However, the precise molecular mechanisms underlying the effects of CS in lung disease are largely unknown. To elucidate these pathophysiological processes, we examined the in vitro and in vivo effects of CS extract (CSE) and CS on the transcription factor, hypoxia-inducible factor 1 (HIF-1). CSE induced concentration- and time-dependent accumulation of HIF-1α protein in human lung epithelial-like cells under non-hypoxic conditions...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27677226/the-role-of-endosomal-toll-like-receptors-in-asthma
#16
Andriana I Papaioannou, Aris Spathis, Konstantinos Kostikas, Petros Karakitsos, Spyros Papiris, Christos Rossios
Asthma is a heterogeneous inflammatory disease caused by association of genetic and environmental factors and its incidence has significantly increased over the latest years. The clinical manifestations of asthma are the result of airway hyper-reactivity to a variety of triggers such as aeroallergens, viral and bacterial components. Toll-like receptors (TLRs) are pathogen associated molecular pattern receptors, which are also expressed in the lung tissue as well as in several cells of the innate and adaptive immune system...
September 24, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27643531/accumulation-of-ubiquitin-and-sequestosome-1-implicate-protein-damage-in-diacetyl-induced-cytotoxicity
#17
Ann F Hubbs, Kara L Fluharty, Rebekah J Edwards, Jamie L Barnabei, John T Grantham, Scott M Palmer, Francine Kelly, Linda M Sargent, Steven H Reynolds, Robert R Mercer, Madhusudan P Goravanahally, Michael L Kashon, John C Honaker, Mark C Jackson, Amy M Cumpston, William T Goldsmith, Walter McKinney, Jeffrey S Fedan, Lori A Battelli, Tiffany Munro, Winnie Bucklew-Moyers, Kimberly McKinstry, Diane Schwegler-Berry, Sherri Friend, Alycia K Knepp, Samantha L Smith, Krishnan Sriram
Inhaled diacetyl vapors are associated with flavorings-related lung disease, a potentially fatal airway disease. The reactive α-dicarbonyl group in diacetyl causes protein damage in vitro. Dicarbonyl/l-xylulose reductase (DCXR) metabolizes diacetyl into acetoin, which lacks this α-dicarbonyl group. To investigate the hypothesis that flavorings-related lung disease is caused by in vivo protein damage, we correlated diacetyl-induced airway damage in mice with immunofluorescence for markers of protein turnover and autophagy...
September 16, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27617449/vascular-endothelial-dysfunction-caused-by-oxidative-stress-is-a-predictor-factor-for-complications-of-obstructive-sleep-apnea-syndrome
#18
K Kilic, B Aktan, M Sedat-Sakat, A Kızıltunç, O Yoruk
Objective: Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive episodes of upper airway obstruction that occur during sleep which leads to cardiovascular, neurovascular and metabolic diseases. The mechanisms of complications in these patients are unclear. In this report, we aimed to determine the cause of oxidative imbalance in patients with OSAS and to evaluate the vascular endothelial dysfunction as a suspect for complications of the disease. Materials and Methods: Fifty patients diagnosed as moderate or severe OSAS (AHI > 15) by polysomnography and 50 healthy volunteers are included in the study...
February 15, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/27611345/elevated-exhalation-of-hydrogen-peroxide-in-patients-with-non-small-cell-lung-cancer-is-not-affected-by-chemotherapy
#19
Agnieszka Krawczyk, Dariusz Nowak, Piotr Jan Nowak, Gianluca Padula, Sylwia Kwiatkowska
OBJECTIVES: Reactive oxygen species, which are implicated in the process of carcinogenesis, are also responsible for cell death during chemotherapy (CHT). Therefore, the aim of the study was to evaluate exhaled H2O2 levels in non-small cell lung cancer (NSCLC) patients before and after CHT. METHODS: Thirty patients (age 61.3 ± 9.3 years) with advanced NSCLC (stage IIIB-IV) and 15 age-matched healthy cigarette smokers were enrolled into the study. Patients received four cycles of cisplatin or carboplatin with vinorelbine every three weeks...
September 9, 2016: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27601994/differential-expression-and-function-of-pde8-and-pde4-in-effector-t-cells-implications-for-pde8-as-a-drug-target-in-inflammation
#20
Amanda G Vang, Chaitali Basole, Hongli Dong, Rebecca K Nguyen, William Housley, Linda Guernsey, Alexander J Adami, Roger S Thrall, Robert B Clark, Paul M Epstein, Stefan Brocke
Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function. The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs). We have previously shown that PDE8A, a PDE isoform with 40-100-fold greater affinity for cAMP than PDE4, is selectively expressed in Teff vs. regulatory T (Treg) cells and controls CD4(+) Teff cell adhesion and chemotaxis. Here, we determined PDE8A expression and function in CD4(+) Teff cell populations in vivo...
2016: Frontiers in Pharmacology
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