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Adult onset asthma

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https://www.readbyqxmd.com/read/28629362/long-term-exposure-to-ambient-ultrafine-particles-and-respiratory-disease-incidence-in-in-toronto-canada-a-cohort-study
#1
Scott Weichenthal, Li Bai, Marianne Hatzopoulou, Keith Van Ryswyk, Jeffrey C Kwong, Michael Jerrett, Aaron van Donkelaar, Randall V Martin, Richard T Burnett, Hong Lu, Hong Chen
BACKGROUND: Little is known about the long-term health effects of ambient ultrafine particles (<0.1 μm) (UFPs) including their association with respiratory disease incidence. In this study, we examined the relationship between long-term exposure to ambient UFPs and the incidence of lung cancer, adult-onset asthma, and chronic obstructive pulmonary disease (COPD). METHODS: Our study cohort included approximately 1.1 million adults who resided in Toronto, Canada and who were followed for disease incidence between 1996 and 2012...
June 19, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28609456/association-of-asthma-with-coronary-heart-disease-a-meta-analysis-of-11-trials
#2
Lida Wang, Shuyan Gao, Mingdong Yu, Zhixin Sheng, Wei Tan
PURPOSE: While the relationship of asthma and coronary heart disease (CHD) (a specific manifestation of cardiovascular disease) has not been described consistently, we tried to defined this relation and explore the influence of gender and asthma status (child- and adult-onset asthma) on this issue. METHODS: We searched published reports that described the relationship of asthma and CHD. RESULTS: Eleven trials were identified, covering 666,355 subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28586254/hospitalizations-for-asthma-among-adults-exposed-to-the-september-11-2001-world-trade-center-terrorist-attack
#3
Sara A Miller-Archie, Hannah T Jordan, Howard Alper, Juan P Wisnivesky, James E Cone, Stephen M Friedman, Robert M Brackbill
OBJECTIVE: We described patterns of asthma hospitalization among persons exposed to the 2001 World Trade Center (WTC) attacks, and assessed whether 9/11-related exposures or comorbidities, including posttraumatic stress disorder (PTSD) and gastroesophageal reflux symptoms (GERS), were associated with an increased rate of hospitalization. METHODS: Data for adult enrollees in the WTC Health Registry, a prospective cohort study, with self-reported physician-diagnosed asthma who resided in New York State on 9/11 were linked to administrative hospitalization data to identify asthma hospitalizations during September 11, 2001-December 31, 2010...
June 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28545787/youth-secrets-are-associated-with-poorer-sleep-and-asthma-symptoms-via-negative-affect
#4
Ledina Imami, Samuele Zilioli, Erin T Tobin, Daniel J Saleh, Heidi S Kane, Richard B Slatcher
OBJECTIVE: Among older children and adolescents, keeping secrets from parents is consistently associated with lower levels of psychological well-being. Further, concealing one's thoughts and emotions has been associated with poor physical health outcomes in adults. However, it remains an open question whether secret-keeping is associated with poorer health and health-related behaviors (such as sleep) among youth and, if those hypothesized links exist, what the psychological mechanisms might be...
May 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28539170/early-menarche-and-new-onset-of-asthma-results-from-the-sapaldia-cohort-study
#5
Sofie Hansen, Nicole Probst-Hensch, Robert Bettschart, Marco Pons, Bénédicte Leynaert, Francisco Gómez Real, Thierry Rochat, Julia Dratva, Cornelia Schneider, Dirk Keidel, Christian Schindler, Elisabeth Zemp
RATIONALE: The association between early menarche and new onset of asthma warrants further investigation in those aged >30 years. OBJECTIVES: Using data from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), we investigated whether early menarche was associated with new onset of asthma in women aged 18-60 years at baseline. METHODS: Our analysis included 2492 women with information on age at menarche and doctor-diagnosed asthma, who had been asthma free at the time of menarche and had complete covariate information...
July 2017: Maturitas
https://www.readbyqxmd.com/read/28526018/infection-mediated-asthma-etiology-mechanisms-and-treatment-options-with-focus-on-chlamydia-pneumoniae-and-macrolides
#6
REVIEW
Wilmore C Webley, David L Hahn
Asthma is a chronic respiratory disease characterized by reversible airway obstruction and airway hyperresponsiveness to non-specific bronchoconstriction agonists as the primary underlying pathophysiology. The worldwide incidence of asthma has increased dramatically in the last 40 years. According to World Health Organization (WHO) estimates, over 300 million children and adults worldwide currently suffer from this incurable disease and 255,000 die from the disease each year. It is now well accepted that asthma is a heterogeneous syndrome and many clinical subtypes have been described...
May 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28524707/asthma-specific-cognitions-self-focused-attention-and-fear-of-negative-evaluation-in-adolescents-and-young-adults-diagnosed-with-childhood-onset-asthma
#7
Ashley N Junghans-Rutelonis, Alayna P Tackett, Kristina I Suorsa, John M Chaney, Larry L Mullins
The present study examined the impact of asthma-specific thought intrusion (TI) and thought suppression (TS) on two cognitive-affective variables (self-focused attention and fear of negative evaluation) among adolescents and young adults (AYAs) diagnosed with childhood-onset asthma. Participants were 290 AYAs who completed assessment questionnaires and participated in a written exercise electronically. Asthma-TI and TS were reported by participants following participation in a writing assignment. Asthma-TI was associated with increased private, public, and social anxiety self-focused attention, and greater fear of negative evaluation...
May 19, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28511697/immunohistology-and-remodeling-in-fatal-pediatric-and-adolescent-asthma
#8
Kristiina Malmström, Jouko Lohi, Antti Sajantila, Frode L Jahnsen, Merja Kajosaari, Seppo Sarna, Mika J Mäkelä
BACKGROUND: Thickening of reticular basement membrane, increased airway smooth muscle mass and eosinophilic inflammation are found in adult fatal asthma. At the present study the histopathology of fatal paediatric and adolescent asthma is evaluated. METHODS: Post-mortem lung autopsies from 12 fatal asthma cases and 8 non-asthmatic control subjects were examined. Thickness of reticular basement membrane (RBM) and percentage of airway smooth muscle (ASM%) mass area were measured and inflammatory cells were counted...
May 16, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28500693/the-clinical-spectrum-of-xanthomatous-lesions-of-the-eyelids
#9
REVIEW
Can Baykal, Algun Polat Ekinci, Kurtulus D Yazganoglu, Nesimi Buyukbabani
Yellowish papules, nodules, or plaques, namely "xanthomatous" lesions, may be seen on the eyelids in the course of various disorders. The prototype is "xanthelasma palpebrarum" (XP) that is localized only to the eyelids and may be associated with hyperlipidemia. On the other hand, different types of normolipemic disorders may also cause xanthomatous eyelid lesions. Among these, Langerhans cell histiocytosis, diffuse normolipemic xanthoma, and non-Langerhans cell histiocytoses (papular xanthoma, juvenile xanthogranuloma, xanthoma disseminatum, adult-onset xanthogranuloma, adult-onset asthma and periocular xanthogranuloma, necrobiotic xanthogranuloma, Erdheim-Chester disease, Rosai-Dorfman disease, and reticulohistiocytosis) can be listed...
May 13, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28499209/precursors-in-adolescence-of-adult-onset-bipolar-disorder
#10
Ayako Hiyoshi, Julia A Sabet, Hugo Sjöqvist, Carren Melinder, Robert J Brummer, Scott Montgomery
BACKGROUND: Although the estimated contribution of genetic factors is high in bipolar disorder, environmental factors may also play a role. This Swedish register-based cohort study of men examined if physical and psychological characteristics in late adolescence, including factors previously linked with bipolar disorder (body mass index, asthma and allergy), are associated with subsequent bipolar disorder in adulthood. Unipolar depression and anxiety are analysed as additional outcomes to identify bipolar disorder-specific associations...
April 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28489959/mood-disorders-in-adult-asthma-phenotypes
#11
Marina Labor, Slavica Labor, Iva Jurić, Vladimir Fijačko, Sanja Popović Grle, Davor Plavec
OBJECTIVE: Studies show high comorbidity of mood disorders in asthma. As asthma is a highly heterogeneous disease with different phenotypes it can be expected that there is a difference in this association with different asthma phenotypes. The aim of our cross-sectional study was to assess the association of specific asthma phenotypes with anxiety and/or depression and their impact on asthma control. METHODS: A cross-sectional study in 201 consecutive adult outpatients with asthma (≥18 years of age) was conducted...
May 10, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28461298/differences-between-asthma-copd-overlap-syndrome-and-adult-onset-asthma
#12
Minna Tommola, Pinja Ilmarinen, Leena E Tuomisto, Lauri Lehtimäki, Jussi Haanpää, Onni Niemelä, Hannu Kankaanranta
Differences between asthma-COPD overlap syndrome (ACOS) and adult-onset asthma are poorly understood. This study aimed to evaluate these differences in a clinical cohort of patients with adult-onset asthma, as a part of the Seinäjoki Adult Asthma Study (SAAS).188 patients were diagnosed with adult-onset asthma and re-evaluated 12 years after diagnosis. They were divided into three groups based on smoking history and post bronchodilator spirometry values: 1) never- and ex-smokers with <10 smoked pack-years; 2) non-obstructive (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ≥0...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28449868/vitamin-d-and-bronchial-asthma-an-overview-of-data-from-the-past-5-years
#13
REVIEW
Sannette C Hall, Devendra K Agrawal
PURPOSE: Vitamin D is a potent immunomodulator capable of dampening inflammatory signals in several cell types involved in the asthmatic response. Its deficiency has been associated with increased inflammation, exacerbations, and overall poor outcomes in patients with asthma. Given the increase in the prevalence of asthma over the past few decades, there has been enormous interest in the use of vitamin D supplementation as a potential therapeutic option. Here, we critically reviewed the most recent findings from in vitro studies, animal models, and clinical trials regarding the role of vitamin D in treating bronchial asthma...
May 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28449285/research-review-childhood-chronic-physical-illness-and-adult-emotional-health-a-systematic-review-and-meta-analysis
#14
REVIEW
Ekin Secinti, Ellen J Thompson, Marcus Richards, Darya Gaysina
BACKGROUND: Childhood chronic physical illness is associated with a greater vulnerability for emotional problems (i.e. depression and anxiety) in childhood. However, little is known about life-long effects of childhood chronic physical illness on mental health. The present study aims to systematically review evidence for associations between eight chronic physical illnesses with childhood onset (arthritis, asthma, cancer, chronic renal failure, congenital heart disease, cystic fibrosis, type 1 diabetes, and epilepsy) and adult emotional problems...
April 27, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28444953/birth-decade-affects-the-sensitization-pattern-and-asthma-risk-in-finnish-adult-population
#15
S Toppila-Salmi, A Luukkainen, R Lemmetyinen, J Karjalainen, H Huhtala, R Renkonen, D Y Wang, M J Mäkelä, J Pekkanen
We have previously shown that sensitizations to several types of allergens distinguish subjects with and without adult-onset asthma in Finland. The aim was to analyze how age affects sensitization and asthma risk. We used previous population-based case-control data (N=456) from Finnish adult asthma patients with one or two matched controls. Asthma was diagnosed based on a typical history of asthmatic symptoms and lung function tests. Allergic sensitization was determined by skin prick test (SPT) to 17 aeroallergens...
April 26, 2017: Allergy
https://www.readbyqxmd.com/read/28438546/clinical-predictors-of-remission-and-persistence-of-adult-onset-asthma
#16
Guus A Westerhof, Hanneke Coumou, Selma B de Nijs, ElsJ Weersink, Elizabeth H Bel
BACKGROUND: Adult-onset asthma is an important but relatively understudied asthma phenotype and little is known about its natural course and prognosis. The remission rate is believed to be low, and it is still obscure which factors predict remission or persistence of the disease. OBJECTIVE: To determine the remission rate, and identify predictors of persistence and remission of adult-onset asthma. METHODS: Two hundred adult patients with recently diagnosed (<1 year) asthma were recruited from secondary and tertiary pulmonary clinics and prospectively followed for 5 years...
April 21, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28402696/chronic-cough-and-an-atypical-pattern-of-peripheral-pulmonary-opacities-a-case-report-secondary-to-suspected-drug-onset
#17
Ronnie Alas, Mark Tony Williams, Ghiam Yamin, Mohsen Rofoogaran
INTRODUCTION: Chronic eosinophilic pneumonia (CEP) is an idiopathic interstitial lung disease with nonspecific symptoms that involves a complex inflammatory cascade. CASE STUDY: A 36-year-old prisoner with a history of psoriasis presented with progressive worsening dyspnea, chest pain, and cough. His symptoms started 2-months after starting adalimumab, a tumor necrosis factor (TNF)-inhibitor, for psoriasis treatment. RESULTS: Initial workup revealed 27% eosinophils on complete blood count, elevated IgE levels on bronchoalveolar lavage, and bilateral peripheral lung opacities on imaging...
April 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28396111/mental-health-services-claims-and-adult-onset-asthma-in-ontario-canada
#18
Teresa To, Kandace Ryckman, Jingqin Zhu, Devon Williams, Laura Y Feldman, Kristian Larsen, Andrea Gershon
BACKGROUND: Living with asthma is associated with a decrease in quality of life due to reductions in activities of daily living and increased psychological stress, both of which are associated with poor mental health outcomes. OBJECTIVE: The objective of this study was to quantify the burden of mental disorders on the adult asthma population and compare the risk of mental health services claims (MHSCs) in the 1 year before and 1 year after asthma diagnosis. METHODS: Ontario residents aged 25 to 65 years with incident physician-diagnosed asthma between April 1, 2005, and March 31, 2012, were included...
April 7, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28393532/sex-bias-in-diagnostic-delay-in-bronchiectasis-an-analysis-of-the-spanish-historical-registry-of-bronchiectasis
#19
Rosa Ma Girón, Javier de Gracia Roldán, Casilda Olveira, Montserrat Vendrell, Miguel Ángel Martínez-García, David de la Rosa, Luis Máiz, Julio Ancochea, Liliana Vázquez, Luis Borderías, Eva Polverino, Eva Martínez-Moragón, Olga Rajas, Joan B Soriano
Diagnostic delay is common in most respiratory diseases, particularly in bronchiectasis. However, sex bias in diagnostic delay has not been studied to date. OBJECTIVE: Assessment of diagnostic delay in bronchiectasis by sex. METHODS: The Spanish Historical Registry of Bronchiectasis recruited adults diagnosed with bronchiectasis from 2002 to 2011 in 36 centres in Spain. From a total of 2113 patients registered we studied 2099, of whom 1125 (53.6%) were women. RESULTS: No differences were found for sex or age (61...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28389738/helicobacter-pylori-infection-increases-the-risk-of-adult-onset-asthma-a-nationwide-cohort-study
#20
Y-C Wang, T-Y Lin, S-T Shang, H-J Chen, C-H Kao, C-C Wu, T-Y Yang
Helicobacter pylori infection (HPI) appears to reduce risk of childhood-onset asthma, but the relationship between HPI and adult-onset asthma is inconclusive. This study explored the potential association between HPI and risk of adult-onset asthma. We conducted a national insurance retrospective cohort study using the longitudinal health insurance database (LHID 2000) in Taiwan. We enrolled the HPI group consisting of 1664 patients with HPI diagnosis between 2000 and 2007, and the non-HPI group consisting of 6,656 age- and sex-matched subjects without HPI...
April 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
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