keyword
https://read.qxmd.com/read/37584539/jejunal-or-ileal-exocrine-drainage-in-pancreas-transplantation-impact-on-gastrointestinal-function
#1
JOURNAL ARTICLE
Daniel T Doherty, Jaimee Tan, Robert McFarlane, Jennifer Kingston, Hussein A Khambalia, Titus Augustine, Zia Moinuddin, David van Dellen
OBJECTIVES: Pancreas transplant can have serious complications requiring salvage pancreatectomy, and surgical approaches should be carefully considered, with jejunal or ileal anastomoses most often employed. The jejunum may reduce gastrointestinal disturbance, whereas the ileum is more immunogenic. Proximal gastrointestinal anastomoses pose challenges with salvage pancreatectomy and creation of high-output stoma, often in the context of end-stage renal failure. Here, we compared outcomes between these techniques...
July 2023: Experimental and Clinical Transplantation
https://read.qxmd.com/read/37394804/development-and-initial-validation-of-the-positive-and-negative-co-rumination-scale
#2
JOURNAL ARTICLE
Hongfei Yang, Chenzhi Huang, Carolyn Maccann, Yujin He, Haixia Jiang, Guoqing Yu
This article presents two studies with data from 750 college students (58.67% females, M age = 20.79 years) and 1035 school students (52.1% girls, M age = 14.44 years) respectively, describing the development and initial validation of the Positive and Negative Co-Rumination Scale (PANCRS). The PANCRS consists of 32 items with 3 second-order factors: Positive Co-Rumination consisting of 3 first-order factors (i.e., Affirmation, Problem-Solving and Enhancing Friendship), Negative Co-Rumination consisting of 4 first-order factors (i...
July 2, 2023: Psychological Reports
https://read.qxmd.com/read/37357452/long-term-follow-up-and-outcome-of-pediatric-acute-pancreatitis-a-multicenter-study
#3
JOURNAL ARTICLE
Burcu Volkan, Bilge Şahin Akkelle, Nevzat Aykut Bayrak, Engin Tutar, Özlem Kalaycık Şengül, Esra Polat, Günsel Kutluk, Deniz Ertem
OBJECTIVE: Over the past decades, the incidence of acute pancreatitis is increasing, but the progression of acute recurrent pancreatitis and chronic pancreatitis is still not well documented in children. The aim of this multicenter study is to delineate the changes that occur in a certain time period in the course of childhood pancreatitis. MATERIALS AND METHODS: The data of consecutive patients hospitalized with acute pancreatitis between 2010 and 2017 in 4 different pediatric gastroenterology units were reviewed...
July 2023: Turkish archives of pediatrics
https://read.qxmd.com/read/36533747/the-last-battle-of-alessandro-farnese-1545-1592
#4
JOURNAL ARTICLE
Emanuele Armocida, Graziella Masciangelo, Ovidio Bussolati
BACKGROUND AND AIM: Alessandro Farnese (1545-1592), 3rd Duke of Parma and Piacenza, one of the most important generals and politicians of his age. He died after a rapid deterioration of his health. The available documents testify that the Duke suffered for a long time from various health problems, such as jaundice, intestinal disorders, gout, dropsy but very little is known about the cause(s) of his death. The aim of this article is to offer for the first time a complete clinical interpretation of Alessandro Farnese's last months of life Methods: A collection of descriptions of symptoms and signs described by his court physician and by the leading biographers of Farnese has been compiled...
December 16, 2022: Acta Bio-medica: Atenei Parmensis
https://read.qxmd.com/read/35943149/butyrate-ameliorates-intestinal-epithelial-barrier-injury-via-enhancing-foxp3-regulatory-t-cell-function-in-severe-acute-pancreatitis-model
#5
JOURNAL ARTICLE
Shen Xiao, Sun Jing, Sun Jiakui, Zou Lei, Liu Ying, Liu Han, Mu Xinwei, Li Weiqin
BACKGROUND: This study aimed to examine the effect of sodium butyrate on severe acute pancreatitis-related gut barrier injury in a rat model and explore its mechanism. METHODS: Male rats randomly fell into 3 groups, that is, the control, the severe acute pancreatitis group, and the severe acute pancreatitis+butyrate group. Rats in the control group received sham operation, while rats in the severe acute pancreatitis group and severe acute pancreatitis+butyrate group received severe acute pancreatitis induction by intraductal infusion of 4% sodium taurocholate...
August 2022: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://read.qxmd.com/read/34882616/pancreatic-cystic-neoplasms-and-pregnancy-a-systematic-review-of-surgical-cases-and-a-case-report-of-a-fully-laparoscopic-distal-pancreatectomy
#6
JOURNAL ARTICLE
Alessandro Fogliati, Mattia Garancini, Fabio Uggeri, Marco Braga, Luca Gianotti
BACKGROUND: Mucinous cystic neoplasms and solid pseudopapillary neoplasms are the most common pancreatic tumors occurring in women of fertile age and in pregnant women. The aim of this study is to provide an updated literature review on this association and to present a fully laparoscopic resection of a pregnancy-associated pancreatic cystic neoplasm. MATERIALS AND METHODS: A systematic literature review was performed using PubMed (MEDLINE), Scopus, Ovid, ISI Web of Science, and Google Scholar for searching...
December 9, 2021: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://read.qxmd.com/read/33177799/insufficient-etiological-workup-of-covid-19-associated-acute-pancreatitis-a-systematic-review
#7
JOURNAL ARTICLE
Márk Félix Juhász, Klementina Ocskay, Szabolcs Kiss, Péter Hegyi, Andrea Párniczky
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, mostly causing respiratory symptoms, is also known to affect the gastrointestinal tract. Several case reports hypothesize that SARS-CoV-2 could be an etiological factor in acute pancreatitis (AP). AIM: To assess all the available evidence in the literature relating to coronavirus disease 2019 (COVID-19) and AP. METHODS: We performed a systematic review of the available literature on the topic...
October 28, 2020: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/33088171/a-large-deletion-spanning-pitx2-and-pancr-in-a-chinese-family-with-axenfeld-rieger-syndrome
#8
JOURNAL ARTICLE
Yayun Qin, Pang Gao, Shanshan Yu, Jingzhen Li, Yuwen Huang, Danna Jia, Zhaohui Tang, Pengcheng Li, Fei Liu, Mugen Liu
Purpose: To identify the genetic cause in a four-generation Chinese family with Axenfeld-Rieger syndrome (ARS). Methods: The family members received clinical examinations of the eye, tooth, periumbilical skin, and heart. Sanger sequencing and whole-exome sequencing (WES) were performed to screen potential mutations. The genomic deletion region around the PITX2 gene was estimated from single nucleotide polymorphism (SNP) data from WES and then confirmed with "quantitative PCR (qPCR) using a set of primers...
2020: Molecular Vision
https://read.qxmd.com/read/31774664/microrna-detection-with-turnover-amplification-via-hybridization-mediated-staudinger-reduction-for-pancreatic-cancer-diagnosis
#9
JOURNAL ARTICLE
Liman Xian, Feng Xu, Jianzhou Liu, Ning Xu, Haidong Li, Haoying Ge, Kun Shao, Jiangli Fan, Guishan Xiao, Xiaojun Peng
The occurrence of and development in the early pathological stage of pancreatic cancer has proved to be associated with microRNAs. However, it remains a great challenge to directly monitor low-expression, and downregulation of, microRNA among living cells, tissues, and serum samples. In this work, Staudinger reduction is first applied in intracellular microRNA detection, establishing a set of smart hybridization-mediated Staudinger reduction probes ( HMSR-probe ) which contain designed oligonucleotide sequences...
December 26, 2019: Journal of the American Chemical Society
https://read.qxmd.com/read/31553925/how-to-assess-and-manage-cognitive-impairment-induced-by-treatments-of-non-central-nervous-system-cancer
#10
REVIEW
Marie Lange, Hélène Castel, Johan Le Fel, Laure Tron, Didier Maillet, Myriam Bernaudin, Omar Touzani, Joy Perrier, Mathieu Boone, Idlir Licaj, Bénédicte Giffard, Martine Dubois, Olivier Rigal, Thomas Durand, Catherine Belin, Damien Ricard, Rozenn Le Gal, Véronique Pancré, Isabelle Hardy-Léger, Florence Joly
A number of neurotoxicity associated with oncological treatments has been reported in non-central nervous system cancers. An expert group presents the state of the art and a guide to help the choice of appropriated tools to assess patient cognition in studies on oncology and neurobehavior in animal models. In addition, current cognitive rehabilitation programs currently under evaluation are also discussed. Cognitive assessments in oncology depend on the research question, study design, cognitive domains, patients' characteristics, psychometric properties of the tests, and whether the tests are supervised or not by a neuropsychologist...
December 2019: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/28935122/prevalence-of-exocrine-pancreatic-insufficiency-in-patients-with-chronic-pancreatitis-without-follow-up-pancr-evol-study
#11
MULTICENTER STUDY
Carlos Marra-Lopez Valenciano, Federico Bolado Concejo, Eva Marín Serrano, Judith Millastre Bocos, Emma Martínez-Moneo, Esperanza Pérez Rodríguez, María Francisco González, Andrés Del Pozo-García, Anaiansi Hernández Martín, Elena Labrador Barba, María Luisa Orera Peña, Enrique de-Madaria
BACKGROUND/OBJECTIVES: Exocrine pancreatic insufficiency (EPI) is an important complication of chronic pancreatitis (CP). Guidelines recommend to rule out EPI in CP, to detect those patients who would benefit from pancreatic enzyme replacement therapy. The aim of this study was to evaluate the prevalence of EPI in patients with CP without follow-up in the last 2 years and to describe their nutritional status and quality of life (QoL). METHODS: This was a cross-sectional, multicenter Spanish study...
February 2018: Gastroenterología y Hepatología
https://read.qxmd.com/read/28822994/glucagon-like-peptide-1-receptor-agonist-stimulates-mitochondrial-bioenergetics-in-human-adipocytes
#12
JOURNAL ARTICLE
Joanna Góralska, Agnieszka Śliwa, Anna Gruca, Urszula Raźny, Monika Chojnacka, Anna Polus, Bogdan Solnica, Małgorzata Malczewska-Malec
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are relatively new pharmacological agents used to normalize glucose level in type 2 diabetes. Recently, GLP-1RAs have been approved for the treatment of obesity to reduce body weight in non-diabetic patients. The extra-pancre-atic effects of GLP-1RAs, as well as their molecular mechanism of action, are still poorly understood. Thus this study was aimed to verify the hypothesis that the mechanism of action of the GLP-1RAs involves mitochondria and that GLP-1RAs administration can improve mitochondrial functions...
2017: Acta Biochimica Polonica
https://read.qxmd.com/read/27798672/dna-methylation-of-pitx2-and-pancr-is-prognostic-for-overall-survival-in-patients-with-resected-adenocarcinomas-of-the-biliary-tract
#13
JOURNAL ARTICLE
Barbara Uhl, Dimo Dietrich, Vittorio Branchi, Alexander Semaan, Pauline Schaefer, Heidrun Gevensleben, Babak Rostamzadeh, Philipp Lingohr, Nico Schäfer, Jörg C Kalff, Glen Kristiansen, Hanno Matthaei
Biliary tract cancers (BTC) are rare but highly aggressive malignant epithelial tumors. In order to improve the outcome in this lethal disease, novel biomarkers for diagnosis, prognosis, and therapy response prediction are urgently needed. DNA promoter methylation of PITX2 variants (PITX2ab, PITX2c) and intragenic methylation of the PITX2 adjacent non-coding RNA (PANCR) were investigated by methylations-specific qPCR assays in formalin-fixed paraffin-embedded tissue from 80 patients after resection for BTC...
2016: PloS One
https://read.qxmd.com/read/27716615/pitx2-and-pancr-dna-methylation-predicts-overall-survival-in-patients-with-head-and-neck-squamous-cell-carcinoma
#14
JOURNAL ARTICLE
Verena Sailer, Emily Eva Holmes, Heidrun Gevensleben, Diane Goltz, Freya Dröge, Luka de Vos, Alina Franzen, Friederike Schröck, Friedrich Bootz, Glen Kristiansen, Andreas Schröck, Dimo Dietrich
BACKGROUND: Squamous cell carcinoma of the head and neck region (HNSCC) is a common malignant disease accompanied by a high risk of local or distant recurrence after curative-intent treatment. Biomarkers that allow for the prediction of disease outcome can guide clinicians with respect to treatment and surveillance strategies. Here, the methylation status of PITX2 and an adjacent lncRNA (PANCR) were evaluated for their ability to predict overall survival in HNSCC patients. RESULTS: PITX2 hypermethylation was associated with a better overall survival (hazard ratio, HR = 0...
November 15, 2016: Oncotarget
https://read.qxmd.com/read/26922689/a-scoring-system-for-the-prediction-of-choledocholithiasis-a-prospective-cohort-study
#15
JOURNAL ARTICLE
Bilal O Al-Jiffry, Samah Khayat, Elfatih Abdeen, Tasadooq Hussain, Mohammed Yassin
BACKGROUND: Techniques for diagnosing choledocholithiasis pose significant morbidity and mortality risks. OBJECTIVES: We aimed to develop and validate a clinical scoring system for predicting choledocholithiasis. DESIGN: Data from a prospectively maintained database of all patients with gallstones. SETTING: Patients were admitted to the general surgery department of a military hospital. PATIENTS AND METHODS: We enrolled consecutive patients with symptomatic gallstones, biliary pancreatitis, obstructive jaundice, or cholangitis, who subsequently underwent biochemical testing and ultrasonography...
2016: Annals of Saudi Medicine
https://read.qxmd.com/read/26862531/effects-of-exendine-4-on-the-differentiation-of-insulin-producing-cells-from-rat-adipose-derived-mesenchymal-stem-cells
#16
JOURNAL ARTICLE
Layasadat Khorsandi, Sadegh Saremy, Ali Khodadadi, Fereshteh Dehbashi
OBJECTIVE: To evaluate the effect of Exendine-4 (EX-4), a Glucagon-like peptide 1 (GLP-1) receptor agonist, on the differentiation of insulin-secreting cells (IPCs) from rat adipose-derived mesenchymal stem cells(ADMSCs). MATERIALS AND METHODS: In this experimental study, ADMSCs were isolated from rat adi- pose tissue and exposed to induction media with or without EX-4. After induction, the existence of IPCs was confirmed by morphology analysis, expression pattern analysis of islet-specific genes (Pdx-1, Glut-2 and Insulin) and insulin synthesis and secretion...
2016: Cell Journal
https://read.qxmd.com/read/26783232/pancr-the-pitx2-adjacent-noncoding-rna-is-expressed-in-human-left-atria-and-regulates-pitx2c-expression
#17
JOURNAL ARTICLE
Shamone R Gore-Panter, Jeffrey Hsu, John Barnard, Christine S Moravec, David R Van Wagoner, Mina K Chung, Jonathan D Smith
BACKGROUND: Genome-wide studies reveal that genetic variants at chromosome 4q25 constitute the strongest locus associated with atrial fibrillation, the most frequent arrhythmia. However, the mechanisms underlying this association are unknown. Our goal is to find and characterize left atrial-expressed transcripts in the chromosome 4q25 atrial fibrillation risk locus that may play a role in atrial fibrillation pathogenesis. METHODS AND RESULTS: RNA sequencing performed on human left/right pairs identified an intergenic long noncoding RNA adjacent to the PITX2 gene, which we have named PANCR (PITX2 adjacent noncoding RNA)...
January 2016: Circulation. Arrhythmia and Electrophysiology
https://read.qxmd.com/read/26634490/association-between-alcohol-dehydrogenase-1c-gene-1-2-polymorphism-and-pancreatitis-risk-a-meta-analysis
#18
JOURNAL ARTICLE
F Fang, J Pan, G H Su, L X Xu, G Li, Z H Li, H Zhao, J Wang
Numerous studies have focused on the relationship be-tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-anal-ysis to more precisely estimate this association. Relevant publications were searched in several widely used databases and 9 eligible studies were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association...
November 30, 2015: Genetics and Molecular Research: GMR
https://read.qxmd.com/read/26344551/impact-of-cancer-and-its-treatments-on-cognitive-function-advances-in-research-from-the-paris-international-cognition-and-cancer-task-force-symposium-and-update-since-2012
#19
REVIEW
Florence Joly, Bénédicte Giffard, Olivier Rigal, Michiel B De Ruiter, Brent J Small, Martine Dubois, Johan LeFel, Sanne B Schagen, Tim A Ahles, Jeffrey S Wefel, Janette L Vardy, Véronique Pancré, Marie Lange, Hélène Castel
CONTEXT: Although cognitive impairments have been identified in patients with non-central nervous system cancer, especially breast cancer, the respective roles of cancer and therapies, and the mechanisms involved in cognitive dysfunction remain unclear. OBJECTIVES: To report a state-of-the-art update from the International Cognitive and Cancer Task Force conference held in 2012. METHODS: A report of the meeting and recent new perspectives are presented...
December 2015: Journal of Pain and Symptom Management
https://read.qxmd.com/read/25505237/effect-of-nasopharyngeal-carcinoma-derived-exosomes-on-human-regulatory-t-cells
#20
COMPARATIVE STUDY
Dhafer Mrizak, Nathalie Martin, Clément Barjon, Anne-Sophie Jimenez-Pailhes, Rami Mustapha, Toshiro Niki, Joël Guigay, Véronique Pancré, Yvan de Launoit, Pierre Busson, Olivier Moralès, Nadira Delhem
BACKGROUND: Regulatory T cells (Treg) and tumor-exosomes are thought to play a role in preventing the rejection of malignant cells in patients bearing nasopharyngeal carcinoma (NPC). METHODS: Treg recruitment by exosomes derived from NPC cell lines (C15/C17-Exo), exosomes isolated from NPC patients' plasma (Patient-Exo), and CCL20 were tested in vitro using Boyden chamber assays and in vivo using a xenograft SCID mouse model (n = 5), both in the presence and absence of anti-CCL20 monoclonal antibodies (mAb)...
January 2015: Journal of the National Cancer Institute
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