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brain trauma traumatic injury biomarker

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https://www.readbyqxmd.com/read/27913365/portable-mtbi-assessment-using-temporal-and-frequency-analysis-of-speech
#1
Louis Daudet, Nikhil Yadav, Matthew Perez, Christian Poellabauer, Sandra Schneider, Alan Huebner
This paper shows that extraction and analysis of various acoustic features from speech using mobile devices can allow the detection of patterns that could be indicative of neurological trauma. This may pave the way for new types of biomarkers and diagnostic tools. Toward this end, we created a mobile application designed to diagnose mild traumatic brain injuries (mTBI) such as concussions. Using this application, data was collected from youth athletes from 47 high schools and colleges in the the Midwestern United States...
December 1, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27889010/neuropsychiatric-aspects-of-concussion
#2
REVIEW
Rajiv Radhakrishnan, Amir Garakani, Lawrence S Gross, Marcia K Goin, Janet Pine, Andrew E Slaby, Calvin R Sumner, David A Baron
Over the past decade, concussion has become the most widely discussed injury in contact sports. However, concussions also occur in several other settings, such as non-contact sports, elderly individuals, young children, military personnel, and victims of domestic violence. Concussion is frequently undiagnosed as a cause of psychiatric morbidity, especially when the patient has no history of loss of consciousness or direct head trauma. Almost all of the extant literature focuses on traumatic brain injury and assumes that concussion is merely a mild form of traumatic brain injury, which has resulted in a lack of understanding about what concussion is, and how to diagnose, monitor, and treat its varied neuropsychiatric symptoms...
December 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27853132/traumatic-brain-injuries
#3
Kaj Blennow, David L Brody, Patrick M Kochanek, Harvey Levin, Ann McKee, Gerard M Ribbers, Kristine Yaffe, Henrik Zetterberg
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe. Mild TBI (the least severe form) is synonymous with concussion and is typically caused by blunt non-penetrating head trauma. The trauma causes stretching and tearing of axons, which leads to diffuse axonal injury - the best-studied pathogenetic mechanism of this disorder. However, mild TBI is defined on clinical grounds and no well-validated imaging or fluid biomarkers to determine the presence of neuronal damage in patients with mild TBI is available...
November 17, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27785968/mild-traumatic-brain-injury-longitudinal-study-of-cognition-functional-status-and-post-traumatic-symptoms
#4
Sureyya Dikmen, Joan Machamer, Nancy Temkin
More than 75% of traumatic brain injuries (TBIs) seeking medical attention are mild, and outcome in that group is heterogeneous. Until sensitive and valid biomarkers are identified, methods are needed to classify mild TBI into more homogeneous subgroups. Four hundred twenty-one adults with mild TBI were divided into groups based on Glasgow Coma Scale (GCS) 13-15 without computed tomography (CT) abnormalities, GCS 15 with CT abnormalities, and GCS 13-14 with CT abnormalities, and were compared with 120 trauma controls on 1-month and 1-year outcomes...
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27750470/controls-can-t-be-ignored
#5
W Frank Peacock
No abstract text is available yet for this article.
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27697434/elevation-of-oxidative-stress-indicators-in-a-pilot-study-of-plasma-following-traumatic-brain-injury
#6
Alison Halstrom, Ellen MacDonald, Claire Neil, Glenn Arendts, Daniel Fatovich, Melinda Fitzgerald
Traumatic brain injury (TBI) encompasses a broad range of injury mechanisms and severity. A detailed determination of TBI severity can be a complex challenge, with current clinical tools sometimes insufficient to tailor a clinical response to a spectrum of patient needs. Blood biomarkers of TBI may supplement clinical assessments but currently available biomarkers have limited sensitivity and specificity. While oxidative stress is known to feature in damage mechanisms following TBI, investigation of blood biomarkers of oxidative stress has been limited...
September 30, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27696022/propofol-inhibits-nlrp3-inflammasome-and-attenuates-blast-induced-traumatic-brain-injury-in-rats
#7
Jie Ma, Wenjing Xiao, Junrui Wang, Juan Wu, Jiandong Ren, Jun Hou, Jianwen Gu, Kaihua Fan, Botao Yu
Increasing evidence has demonstrated that inflammatory response plays a crucial role in the pathogenesis of secondary injury following blast-induced traumatic brain injury (bTBI). Propofol, a lipid-soluble intravenous anesthetic, has been shown to possess therapeutic benefit during neuroinflammation on various brain injury models. Recent findings have proved that the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome involved in the process of the inflammatory response following brain trauma, may probably be a promising target in the treatment of bTBI...
December 2016: Inflammation
https://www.readbyqxmd.com/read/27604350/utility-of-neuron-specific-enolase-in-traumatic-brain-injury-relations-to-s100b-levels-outcome-and-extracranial-injury-severity
#8
Eric Peter Thelin, Emma Jeppsson, Arvid Frostell, Mikael Svensson, Stefania Mondello, Bo-Michael Bellander, David W Nelson
BACKGROUND: In order to improve assessment and outcome prediction in patients suffering from traumatic brain injury (TBI), cerebral protein levels in serum have been suggested as biomarkers of injury. However, despite much investigation, biomarkers have yet to reach broad clinical utility in TBI. This study is a 9-year follow-up and clinical experience of the two most studied proteins, neuron-specific enolase (NSE) and S100B, in a neuro-intensive care TBI population. Our aims were to investigate to what extent NSE and S100B, independently and in combination, could predict outcome, assess injury severity, and to investigate if the biomarker levels were influenced by extracranial factors...
September 8, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27588567/lipid-peroxidation-and-tyrosine-nitration-in-traumatic-brain-injury-insights-into-secondary-injury-from-redox-proteomics
#9
REVIEW
D Allan Butterfield, Tanea T Reed
Traumatic brain injury (TBI) is a spontaneous event in which sudden trauma and secondary injury cause brain damage. Symptoms of TBI can range from mild to severe depending on extent of injury. The outcome can span from complete patient recovery to permanent memory loss and neurological decline. Currently, there is no known cure for TBI; however, immediate medical attention after injury is most beneficial for patient recovery. It is a well-established concept that imbalances in the production of reactive oxygen species (ROS), reactive nitrogen species (RNS), and native antioxidant mechanisms have been shown to increase oxidative stress...
September 2, 2016: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/27538670/early-expression-of-serum-neutrophil-gelatinase-associated-lipocalin-ngal-is-associated-with-neurological-severity-immediately-after-traumatic-brain-injury
#10
Jinbing Zhao, Haodong Chen, Meijuan Zhang, Yuhai Zhang, Chunfa Qian, Yong Liu, Shengxue He, Yuanjie Zou, Hongyi Liu
PURPOSE: Intracranial bleeding and inflammatory reactions are common consequences of traumatic brain injury (TBI). Neutrophil gelatinase-associated lipocalin (NGAL), an iron-handling and acute phase protein, may participate in the pathogenesis of TBI. Therefore, we hypothesize that NGAL may be of high diagnostic and therapeutic relevance in the prognosis of TBI. METHODS: 74 subjects were recruited in this study. 30 TBI patients receiving emergent operation were designated as severe TBI group (sTBI), 24 TBI patients receiving conservative treatment as mild TBI group (mTBI), while 20 age-matched healthy volunteers as healthy controls (CNT)...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27487732/cerebrospinal-fluid-ccl2-is-an-early-response-biomarker-for-blast-overpressure-wave-induced-neurotrauma-in-rats
#11
Ying Wang, Yanling Wei, Samuel Oguntaya, Donna Wilder, Lawrence Tong, Yan Su, Irene Gist, Peethambaran Arun, Joseph Long
Chemokines and their receptors are of great interest within the milieu of immune responses elicited in CNS in response to trauma. Chemokine ligand 2 (CCL2), which is also known as monocyte chemotactic protein-1 (MCP-1), has been implicated in the pathogenesis of traumatic brain injury, brain ischemia, Alzheimer's disease and other neurodegenerative diseases. In this study, we investigated the time-course of CCL2 accumulation in cerebrospinal fluid (CSF) following exposures to single and repeated blast overpressures of varied intensities along with the neuropathological changes and motor deficits resulting from these blast conditions...
August 3, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27468558/advances-in-biomarkers-in-critical-ill-polytrauma-patients
#12
REVIEW
Marius Papurica, Alexandru F Rogobete, Dorel Sandesc, Raluca Dumache, Carmen A Cradigati, Mirela Sarandan, Radu Nartita, Sonia E Popovici, Ovidiu H Bedreag
BACKGROUND: The complexity of the cases of critically ill polytrauma patients is given by both the primary, as well as the secondary, post-traumatic injuries. The severe injuries of organ systems, the major biochemical and physiological disequilibrium, and the molecular chaos lead to a high rate of morbidity and mortality in this type of patient. The 'gold goal' in the intensive therapy of such patients resides in the continuous evaluation and monitoring of their clinical status. Moreover, optimizing the therapy based on the expression of certain biomarkers with high specificity and sensitivity is extremely important because of the clinical course of the critically ill polytrauma patient...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27468268/blood-biomarkers-for-evaluation-of-perinatal-encephalopathy
#13
REVIEW
Ernest M Graham, Irina Burd, Allen D Everett, Frances J Northington
Recent research in identification of brain injury after trauma shows many possible blood biomarkers that may help identify the fetus and neonate with encephalopathy. Traumatic brain injury shares many common features with perinatal hypoxic-ischemic encephalopathy. Trauma has a hypoxic component, and one of the 1st physiologic consequences of moderate-severe traumatic brain injury is apnea. Trauma and hypoxia-ischemia initiate an excitotoxic cascade and free radical injury followed by the inflammatory cascade, producing injury in neurons, glial cells and white matter...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27450760/time-course-of-cerebrospinal-fluid-inflammatory-biomarkers-and-relationship-to-6-month-neurologic-outcome-in-adult-severe-traumatic-brain-injury
#14
Enyinna L Nwachuku, Ava M Puccio, Adeolu Adeboye, Yue-Fang Chang, Jinho Kim, David O Okonkwo
OBJECTIVE: Activation of the inflammatory cascade is a known pathophysiologic process in severe traumatic brain injury (TBI) with yet non-standardized scientific data regarding relationship to outcome. The understanding of the time course of expression of cerebrospinal fluid (CSF) biomarker levels following severe TBI is an important step toward using these biomarkers to measure injury severity and/or early response to therapeutic interventions. The objective of the current study is to report the time course and values of a battery of CSF inflammatory biomarkers following severe TBI in our reasonably sized patient cohort...
October 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27315805/kinetic-modelling-of-serum-s100b-after-traumatic-brain-injury
#15
A Ercole, E P Thelin, A Holst, B M Bellander, D W Nelson
BACKGROUND: An understanding of the kinetics of a biomarker is essential to its interpretation. Despite this, little kinetic modelling of blood biomarkers can be found in the literature. S100b is an astrocyte related marker of brain injury used primarily in traumatic brain injury (TBI). Serum levels are expected to be the net result of a multi-compartmental process. The optimal sample times for TBI prognostication, and to follow injury development, are unclear. The purpose of this study was to develop a kinetic model to characterise the temporal course of serum S100b concentration after primary traumatic brain injury...
June 17, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27295302/preliminary-findings-on-biomarker-levels-from-extracerebral-sources-in-patients-undergoing-trauma-surgery-potential-implications-for-tbi-outcome-studies
#16
H Wolf, C Krall, G Pajenda, S Hajdu, H Widhalm, J Leitgeb, K Sarahrudi
BACKGROUND: Despite several experimental studies on the role of S100B and NSE in fractures, no studies on the influence of surgery on the biomarker serum levels have been performed yet. METHODS: The serum levels of S100B and NSE were analysed in patients with fractures that were located in the spine (group 1, n = 35) or in the lower extremity (group 2, n = 32) pre- and post-operatively. RESULTS: The mean S100B serum level showed a significant increase (p = 0...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27242516/impact-of-mild-head-injury-on-neuropsychological-performance-in-healthy-older-adults-longitudinal-assessment-in-the-aibl-cohort
#17
Matthew A Albrecht, Colin L Masters, David Ames, Jonathan K Foster
Traumatic brain injury (TBI) is suggested to be a significant risk factor for dementia. However, little research has been conducted into long-term neuropsychological outcomes after head trauma. Participants from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) who had recovered after sustaining a mild TBI involving loss of consciousness more than 5 years previously were compared with matched controls across a 3-year period. Bayesian nested-domain modeling was used to estimate the effect of TBI on neuropsychological performance...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27206278/sympathoadrenal-activation-is-associated-with-acute-traumatic-coagulopathy-and-endotheliopathy-in-isolated-brain-injury
#18
Alex P Di Battista, Sandro B Rizoli, Brandon Lejnieks, Arimie Min, Maria Y Shiu, Henry T Peng, Andrew J Baker, Michael G Hutchison, Nathan Churchill, Kenji Inaba, Bartolomeu B Nascimento, Airton Leonardo de Oliveira Manoel, Andrew Beckett, Shawn G Rhind
BACKGROUND: Acute coagulopathy after traumatic brain injury (TBI) involves a complex multifactorial hemostatic response that is poorly characterized. OBJECTIVES: To examine early posttraumatic alterations in coagulofibrinolytic, endothelial, and inflammatory blood biomarkers in relation to sympathetic nervous system (SNS) activation and 6-month patient outcomes, using multivariate partial least-squares (PLS) analysis. PATIENTS AND METHODS: A multicenter observational study of 159 adult isolated TBI patients admitted to the emergency department at an urban level I trauma center, was performed...
September 2016: Shock
https://www.readbyqxmd.com/read/27155585/the-prognostic-value-of-plasma-nesfatin-1-concentrations-in-patients-with-traumatic-brain-injury
#19
Gang-Qun Wu, Xiao-Min Chou, Wen-Jian Ji, Xiao-Gang Yang, Luo-Xin Lan, Yan-Jun Sheng, Yang-Fang Shen, Jian-Rong Li, Guo-Zhong Huang, Wen-Hua Yu, Xiao-Qiao Dong, Quan Du, Ding-Bo Yang, Zu-Yong Zhang, Hao Wang, Yong-Feng Shen, Li Jiang
BACKGROUND: Nesfatin-1 is related to inflammation. Its increased circulating concentrations are associated with the severity and prognosis of subarachnoid hemorrhage. In-hospital major adverse events (IMAEs), including acute traumatic coagulopathy, progressive hemorrhagic injury and posttraumatic cerebral infarction, are correlated with mortality after traumatic brain injury (TBI). The present study was designed to investigate the changes of plasma nesfatin-1 concentrations and further assess its association with inflammation, trauma severity, in-hospital mortality and IMAEs following TBI...
July 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27141807/-advances-in-biomarkers-of-mild-traumatic-brain-injury-in-cerebrospinal-fluid-and-blood
#20
REVIEW
Wen Huang, Shang-xun Li, Xue-jian Li, Hong-yun Xu
Mild traumatic brain injury (MTBI) is defined as a mild brain trauma resulting in a short loss of consciousness and alteration of mental status. It may also occasionally develop persistent and progressive symptoms. It has been confirmed that MTBI causes changes of anatomic structures in central nervous system and biomarkers in the body fluid. However, there is no sufficient research on relevance among threshold for the brain injury, individual vulnerability and duration of disturbance of consciousness. Furthermore, there are no reliable diagnostic methods to establish whether a blow to the head is sufficient to cause the brain injury...
December 2015: Fa Yi Xue za Zhi
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