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https://www.readbyqxmd.com/read/29346776/loss-of-an-androgen-inactivating-and-isoform-specific-hsd17b4-splice-form-enables-emergence-of-castration-resistant-prostate-cancer
#1
Hyun-Kyung Ko, Michael Berk, Yoon-Mi Chung, Belinda Willard, Rohan Bareja, Mark Rubin, Andrea Sboner, Nima Sharifi
Castration-resistant prostate cancer (CRPC) requires tumors to engage metabolic mechanisms that allow sustained testosterone and/or dihydrotestosterone to stimulate progression. 17β-Hydroxysteroid dehydrogenase type 4 (17βHSD4), encoded by HSD17B4, is thought to inactivate testosterone and dihydrotestosterone by converting them to their respective inert 17-keto steroids. Counterintuitively, HSD17B4 expression increases in CRPC and predicts poor prognosis. Here, we show that, of five alternative splice forms, only isoform 2 encodes an enzyme capable of testosterone and dihydrotestosterone inactivation...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346775/brd4-promotes-dna-repair-and-mediates-the-formation-of-tmprss2-erg-gene-rearrangements-in-prostate-cancer
#2
Xiangyi Li, GuemHee Baek, Susmita G Ramanand, Adam Sharp, Yunpeng Gao, Wei Yuan, Jon Welti, Daniel N Rodrigues, David Dolling, Ines Figueiredo, Semini Sumanasuriya, Mateus Crespo, Adam Aslam, Rui Li, Yi Yin, Bipasha Mukherjee, Mohammed Kanchwala, Ashley M Hughes, Wendy S Halsey, Cheng-Ming Chiang, Chao Xing, Ganesh V Raj, Sandeep Burma, Johann de Bono, Ram S Mani
BRD4 belongs to the bromodomain and extraterminal (BET) family of chromatin reader proteins that bind acetylated histones and regulate gene expression. Pharmacological inhibition of BRD4 by BET inhibitors (BETi) has indicated antitumor activity against multiple cancer types. We show that BRD4 is essential for the repair of DNA double-strand breaks (DSBs) and mediates the formation of oncogenic gene rearrangements by engaging the non-homologous end joining (NHEJ) pathway. Mechanistically, genome-wide DNA breaks are associated with enhanced acetylation of histone H4, leading to BRD4 recruitment, and stable establishment of the DNA repair complex...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346666/gypsy-roma-and-traveller-access-to-and-engagement-with-health-services-a-systematic-review
#3
Alison McFadden, Lindsay Siebelt, Anna Gavine, Karl Atkin, Kerry Bell, Nicola Innes, Helen Jones, Cath Jackson, Haggi Haggi, Steve MacGillivray
Background: Gypsy, Roma and Traveller people represent the most disadvantaged minority groups in Europe, having the poorest health outcomes. This systematic review addressed the question of how Gypsy, Roma and Traveller people access healthcare and what are the best ways to enhance their engagement with health services. Methods: Searches were conducted in 21 electronic databases complemented by a focussed Google search. Studies were included if they had sufficient focus on Gypsy, Roma or Traveller populations; reported data pertinent to healthcare service use or engagement and were published in English from 2000 to 2015...
February 1, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29346663/resident-participation-in-neighbourhood-audit-tools-a-scoping-review
#4
Aafke C L Hofland, Jeroen Devilee, Elise van Kempen, Lea den Broeder
Background: Healthy urban environments require careful planning and a testing of environmental quality that goes beyond statutory requirements. Moreover, it requires the inclusion of resident views, perceptions and experiences that help deepen the understanding of local (public health) problems. To facilitate this, neighbourhoods should be mapped in a way that is relevant to them. One way to do this is participative neighbourhood auditing. This paper provides an insight into availability and characteristics of participatory neighbourhood audit instruments...
February 1, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29346375/how-do-we-reach-the-girls-and-women-who-are-the-hardest-to-reach-inequitable-opportunities-in-reproductive-and-maternal-health-care-services-in-armed-conflict-and-forced-displacement-settings-in-colombia
#5
Juan Carlos Rivillas, Raul Devia Rodriguez, Gloria Song, Andréanne Martel
OBJECTIVES: This paper assesses inequalities in access to reproductive and maternal health services among females affected by forced displacement and sexual and gender-based violence in conflict settings in Colombia. This was accomplished through the following approaches: first, we assessed the gaps and gradients in three selected reproductive and maternal health care services. Second, we analyzed the patterns of inequalities in reproductive and maternal health care services and changes over time...
2018: PloS One
https://www.readbyqxmd.com/read/29346226/preparing-physiotherapy-students-for-clinical-placement-student-perceptions-of-low-cost-peer-simulation-a-mixed-methods-study
#6
Narelle Dalwood, Stephen Maloney, Narelle Cox, Prue Morgan
INTRODUCTION: Simulation is increasingly used in health care education, yet the organizational and financial costs can be prohibitive. This study aimed to investigate whether peer simulation is perceived by third-year undergraduate physiotherapy students as valuable for clinical placement preparation. METHODS: Third-year undergraduate physiotherapy students participated in a 9-week peer simulation program, using each other as patients, and were invited to complete two surveys evaluating perceptions of the program...
January 17, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29346161/promotion-of-exercise-in-multiple-sclerosis-through-healthcare-providers
#7
Robert W Motl, Elizabeth A Barstow, Sarah Blaylock, Emma Richardson, Yvonne C Learmonth, Matthew Fifolt
Participation in exercise yields meaningful benefits among persons with multiple sclerosis(MS), yet this population engages in low rates of health-promoting physical activity. The disconnect between evidence of benefits and rates of participation requires consideration of new opportunities for changing this health behavior. The current paper hypothesizes that the patient-provider interaction offers a fertile opportunity for promoting exercise behavior in MS.
January 15, 2018: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/29346136/interdisciplinary-team-evaluation-an-effective-method-for-the-diagnostic-assessment-of-autism-spectrum-disorder
#8
Jennifer Gerdts, James Mancini, Emily Fox, Candace Rhoads, Tracey Ward, Erin Easley, Raphael A Bernier
OBJECTIVE: The objective of this research is to assess the feasibility of an interdisciplinary team diagnostic assessment model for autism spectrum disorder (ASD). METHOD: Medical records from 366 patients evaluated for ASD at the Seattle Children's Autism Center (SCAC) were reviewed. ASD diagnostic outcomes, provider satisfaction, engagement in follow-up care, billed time, and reimbursement amounts were compared in patients evaluated through an interdisciplinary team approach (n = 91) with those seen in multidisciplinary evaluations led by either a psychologist (n = 165) or a physician (n = 110)...
January 12, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29346006/public-health-education-teaching-epidemiology-in-high-school-classrooms
#9
Emily D'Agostino
Epidemiology instruction has expanded at the undergraduate level in part because it increases student critical thinking and scientific literacy, promotes students' perception of public health as both practical and relevant, and empowers students as independent, lifelong learners. Why then are more high schools not adopting epidemiology as a course requirement for students? Although prior iterations of high school epidemiology courses are noteworthy for incorporating active and participatory learning, embedding them into existing and continually shifting curricula is challenging and time-consuming, especially for teachers not trained in the field...
January 18, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29345992/the-effect-of-patient-navigation-on-the-likelihood-of-engagement-in-clinical-care-for-hiv-infected-individuals-leaving-jail
#10
Janet J Myers, Mi-Suk Kang Dufour, Kimberly A Koester, Mark Morewitz, Rebecca Packard, Kate Monico Klein, Milton Estes, Brie Williams, Alissa Riker, Jacqueline Tulsky
OBJECTIVES: To compare the effectiveness of patient navigation-enhanced case management in supporting engagement in HIV care upon release from jail relative to existing services. METHODS: We randomized 270 HIV-infected individuals to receive navigation-enhanced case management for 12 months or standard case management for 90 days following release from jail between 2010 and 2013. Participants were interviewed at 2, 6, and 12 months after release. We abstracted medical data from jail and city health records...
January 18, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29345930/%C3%AE-amino-%C3%AE-carboxymuconate-%C3%AE%C2%B5-semialdehyde-decarboxylase-acmsd-inhibitors-as-novel-modulators-of-de-novo-nicotinamide-adenine-dinucleotide-nad-biosynthesis
#11
Roberto Pellicciari, Paride Liscio, Nicola Giacchè, Francesca De Franco, Andrea Carotti, Janet Robertson, Lucia Cialabrini, Elena Katsyuba, Nadia Raffaelli, Johan Auwerx
NAD+ has a central function in linking cellular metabolism to major cell signaling and gene regulation pathways. Defects in NAD+ homeostasis underpin a wide range of diseases, including cancer, metabolic disorders, and aging. Whilst the beneficial effects of NAD+ boosting are well established in mitochondrial fitness, metabolism, and lifespan, to date, no therapeutic enhancers of de novo NAD+ biosynthesis have been reported. Herein we report the discovery of 3-[[[5-cyano-1,6-dihydro-6-oxo-4-(2-thienyl)-2-pyrimidinyl]thio]methyl]phenylacetic acid (TES-1025, 22) the first potent and selective inhibitor of human ACMSD (IC50 = 0...
January 18, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29345727/the-petal-project-an-innovation-in-sexual-healthcare-and-education-for-kenyan-schoolgirl
#12
Karen M Parker
In the western province of Nyanza in Kenya, girls and women face an issue all too common in the developing world-little or no access to affordable means to effectively managing their menstrual flow. As a result, many stay at home or drop out of school because they are teased and embarrassed. Some approach men for money to buy pads and are forced, in return, to engage in transactional sex. The girls may not be able to return to school at all due to pregnancy. The story literally and figuratively continues to cycle, keeping girls in positions of dependency and poverty...
January 18, 2018: Nursing Forum
https://www.readbyqxmd.com/read/29345549/veterinary-medical-students-motivations-for-exercise
#13
Kenneth D Royal, Suzanne A Hunt, Liara M Gonzalez, Gregory A Lewbart, Kate M Bailey
The Centers for Disease Control (CDC) declares exercise to be one of the most important activities one can do to improve health. The benefits of exercise are well documented and include both physiologic and psychological health. Given the current landscape of wellness issues in veterinary medical education, it is necessary that students engage in exercise activities to manage stress and increase overall health. Therefore, to develop targeted interventions with the greatest likelihood for success, it is first necessary to understand what motivates veterinary medical students to exercise given their unique situational and environmental factors...
January 18, 2018: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/29345520/correlates-of-physical-activity-among-middle-aged-and-older-adults-with-hazardous-drinking-habits-in-six-low-and-middle-income-countries
#14
Davy Vancampfort, Brendon Stubbs, Mats Hallgren, Andreas Lundin, James Mugisha, Ai Koyanagi
We investigated physical activity (PA) correlates among middle-aged and older adults (aged ≥50 years) with hazardous drinking patterns in six low-and-middle-income countries (LMICs). Cross-sectional data were analyzed from the World Health Organization's Study on Global Ageing and Adult Health. Hazardous drinking was defined as consuming >7 (females) or >14 (males) standard drinks per week. Participants were dichotomized into low (i.e. not meeting 150 minutes of moderate PA / week) and moderate-to-high physically active groups...
January 18, 2018: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/29345495/milton-frank-shore-1928-2017
#15
Robert Henley Woody
Presents an obituary for Milton Frank Shore, who passed away on January 6, 2017, due to pneumonia. During a long career, he was a tireless advocate for children, particularly those who were underserved. In addition, he made important contributions as an author, editor, and administrator. He was actively engaged in independent practice at the time of his death. Milt was one of the founders of American Psychological Association (APA) Division 37 (Child, Youth, and Family Services) and served as its president (1978-1979)...
January 2018: American Psychologist
https://www.readbyqxmd.com/read/29345493/jon-douglas-carlson-1945-2017
#16
Matt Englar-Carlson, Jeffrey Kottler
Presents an obituary for Jon Douglas Carlson, who passed away on February 1, 2017, in Madison, Wisconsin, due to complications from a bone marrow transplant. Jon was a leading figure within counseling, psychology, and education, with a specific focus on Adlerian theory and practice. His professional work was informed by over 40 years of clinical practice. During his distinguished career, he published 64 books, 185 articles, and more than 300 training videos adopted by universities around the world. Carlson's professional legacy lives on through the many books and countless hours of professional video sessions, as well as through the healthy, engaged lives of the clients, students, and colleagues that he encouraged, mentored, and supported...
January 2018: American Psychologist
https://www.readbyqxmd.com/read/29345481/the-influence-of-low-barrier-and-voluntary-service-policies-on-survivor-empowerment-in-a-domestic-violence-housing-organization
#17
Nkiru Nnawulezi, Surbhi Godsay, Cris M Sullivan, Suzanne Marcus, Margaret Hacskaylo
The purpose of community-based domestic violence crisis housing programs (e.g., shelters) is to provide a safe setting that promotes empowerment for survivors of intimate partner violence. For staff to reach this aim, the program must have formal structures and processes in place to support such efforts. This study explored how low-barrier and voluntary service policies influenced staff practices and survivor empowerment. Low-barrier policies require that programs remove barriers that prevent survivors, particularly those who have mental health concerns and/or addictions, from being able to access services...
January 18, 2018: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/29345477/an-exploratory-study-of-stress-and-coping-among-black-college-men
#18
Janelle R Goodwill, Daphne C Watkins, Natasha C Johnson, Julie Ober Allen
Research on coping mechanisms among Black Americans is robust, yet there is a dearth of studies that use qualitative approaches to examine coping specifically among young Black men. The current and historical landscape of race relations in the United States calls for additional concern and exploration of this topic. To fill gaps in this area, this study uncovered the ways Black college men cope with various stressors that impact their mental health. Eleven qualitative interviews were conducted with 18- to 25-year-old Black men enrolled at a college in the Midwest who participated in the Young Black Men, Masculinities, and Mental Health (YBMen) project...
January 18, 2018: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/29345376/role-of-negative-regulation-of-immune-signaling-pathways-in-neutrophil-function
#19
REVIEW
Veronica Azcutia, Charles A Parkos, Jennifer C Brazil
Polymorphonuclear neutrophils (PMNs) play a critical role in host defense against infection and in the resolution of inflammation. However, immune responses mediated by PMN must be tightly regulated to facilitate elimination of invading pathogens without inducing detrimental inflammation and host tissue damage. Specific engagement of cell surface immunoreceptors by a diverse range of extracellular signals regulates PMN effector functions through differential activation of intracellular signaling cascades. Although mechanisms of PMN activation mediated via cell signaling pathways have been well described, less is known about negative regulation of PMN function by immune signaling cascades...
December 19, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345344/differential-outcomes-of-tlr2-engagement-in-inflammation-induced-preterm-birth
#20
Monica Cappelletti, Matthew J Lawson, Calvin C Chan, Adrienne N Wilburn, Senad Divanovic
Preterm birth (PTB) is the leading cause of neonatal mortality worldwide. Infection and inflammation are considered main causes of PTB. Among multiple pathogens, Gram-positive bacteria are commonly linked with induction of PTB. Although activation of innate immune responses, via TLR2 engagement, by Gram-positive bacteria is a likely cause, whether induction of PTB depends on the potency of specific microbial components to induce Toll-like receptor (TLR)2-driven inflammation has not been elucidated. Here, we show that TLR2 activation by synthetic lipopeptides, Pam2Cys, and Pam3Cys specifically, variably influenced inflammation and subsequent induction of PTB...
December 28, 2017: Journal of Leukocyte Biology
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