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https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#1
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166664/is-there-a-reasonable-excuse-for-not-providing-post-operative-analgesia-when-using-animal-models-of-peripheral-neuropathic-pain-for-research-purposes
#2
Sara Hestehave, Gordon Munro, Rie Christensen, Tina Brønnum Pedersen, Lars Arvastson, Philip Hougaard, Klas S P Abelson
INTRODUCTION: The induction of neuropathic pain-like behaviors in rodents often requires surgical intervention. This engages acute nociceptive signaling events that contribute to pain and stress post-operatively that from a welfare perspective demands peri-operative analgesic treatment. However, a large number of researchers avoid providing such care based largely on anecdotal opinions that it might interfere with model pathophysiology in the longer term. OBJECTIVES: To investigate effects of various peri-operative analgesic regimens encapsulating different mechanisms and duration of action, on the development of post-operative stress/welfare and pain-like behaviors in the Spared Nerve Injury (SNI)-model of neuropathic pain...
2017: PloS One
https://www.readbyqxmd.com/read/29166565/hospital-based-physicians-intubation-decisions-and-associated-mental-models-when-managing-a-critically-and-terminally-ill-older-patient
#3
Shannon Haliko, Julie Downs, Deepika Mohan, Robert Arnold, Amber E Barnato
BACKGROUND: Variation in the intensity of acute care treatment at the end of life is influenced more strongly by hospital and provider characteristics than patient preferences. OBJECTIVE: We sought to describe physicians' mental models (i.e., thought processes) when encountering a simulated critically and terminally ill older patient, and to compare those models based on whether their treatment plan was patient preference-concordant or preference-discordant. METHODS: Seventy-three hospital-based physicians from 3 academic medical centers engaged in a simulated patient encounter and completed a mental model interview while watching the video recording of their encounter...
November 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29166432/engagement-in-physical-education-classes-and-health-among-young-people-does-sports-practice-matter-a-cross-sectional-study
#4
Diogo Henrique Constantino Coledam, Philippe Fanelli Ferraiol
CONTEXT AND OBJECTIVE: Physical education classes aim to promote health but it is unknown whether benefits occur independently of sports practice. The purpose of this study was to examine associations between engagement in physical education classes and physical fitness and obesity according to sports practice among Brazilian students. DESIGN AND SETTING: Cross-sectional school-based study involving 737 students aged 10-17 years in southern Brazil. METHODS: Engagement in physical education classes and sports practice were analyzed using a self-report questionnaire...
November 17, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29166355/restoring-faculty-vitality-in-academic-medicine-when-burnout-threatens
#5
Darshana T Shah, Valerie N Williams, Luanne E Thorndyke, E Eugene Marsh, Roberta E Sonnino, Steven M Block, Thomas R Viggiano
Increasing rates of burnout-with accompanying stress and lack of engagement-among faculty, residents, students, and practicing physicians have caused alarm in academic medicine. Central to the debate among academic medicine's stakeholders are oft-competing issues of social accountability; cost containment; effectiveness of academic medicine's institutions; faculty recruitment, retention, and satisfaction; increasing expectations for faculty; and mission-based productivity.The authors propose that understanding and fostering what contributes to faculty and institutional vitality is central to preventing burnout during times of change...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29166294/roles-and-experiences-of-parents-in-necrotizing-enterocolitis-an-international-survey-of-parental-perspectives-of-communication-in-the-nicu
#6
Samir K Gadepalli, Jennifer Canvasser, Yael Eskenazi, Megan Quinn, Jae H Kim, Sheila M Gephart
BACKGROUND: Although partnering with parents is important to improving neonatal outcomes, no studies have investigated what parents are taught, remember, or experience when their child is afflicted with necrotizing enterocolitis (NEC). PURPOSE: To characterize parental perceptions of communication and support they were given about NEC. METHODS: An online survey was developed, reviewed for face validity, and then administered to parents whose child had experienced NEC...
November 20, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29166247/does-sodium-knowledge-affect-dietary-choices-and-health-behaviors-results-from-a-survey-of-los-angeles-county-residents
#7
George Dewey, Ranjana N Wickramasekaran, Tony Kuo, Brenda Robles
INTRODUCTION: In 2010, the Los Angeles County Department of Public Health launched a local sodium-reduction initiative to address the rising prevalence of high blood pressure (hypertension) and related cardiovascular conditions in the population. To inform this effort, we evaluated self-reported knowledge and health behaviors related to sodium intake among Los Angeles County residents. METHODS: We administered 3 cross-sectional Internet panel surveys on knowledge about dietary sodium to a sample of Los Angeles County adults, at intervals from December 2014 through August 2016...
November 22, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29166197/combining-natural-ingredients-and-beliefs-the-dayak-tribe-s-experience-caring-for-sick-children-with-traditional-medicine
#8
Shinta Widiastuty Anggerainy, Dessie Wanda, Happy Hayati
Instead of seeking conventional health care, the Dayak tribe in Borneo, Indonesia, treats sick children at home with traditional medicine. The objective of this descriptive, qualitative study was to explore the Dayak tribe's use of traditional medicine to care for sick children. Comprehensive interviews were conducted with 10 caregivers, with collected data analyzed using content analysis. Key recurring themes identified were: 1) traditional medicine as first aid; 2) ease of access and cost-effectiveness; 3) traditional medicine was not always effective; 4) a combination of natural ingredients and beliefs; 5) the importance of "communicating" with plants; and 6) engagement with metaphysical forces...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166010/conformational-dynamics-of-asparagine-at-coiled-coil-interfaces
#9
Franziska Thomas, Ai Niitsu, Alain Oregioni, Gail J Bartlett, Derek N Woolfson
Coiled coils (CCs) are among the best-understood protein folds. Nonetheless, there are gaps in our knowledge of CCs. Notably, CCs are likely to be structurally more dynamic than often considered. Here, we explore this in an abundant class of CCs, parallel dimers, focusing on polar asparagine (Asn) residues in the hydrophobic interface. It is well documented that such inclusions discriminate between different CC oligomers, which has been rationalized in terms of whether the Asn can make side-chain hydrogen bonds or not...
November 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/29165951/step-up-and-start-to-engage-professional-power
#10
Alice M Hellebrand
No abstract text is available yet for this article.
May 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165915/development-and-implementation-of-a-radiation-therapy-incident-learning-system-compatible-with-local-workflow-and-a-national-taxonomy
#11
Logan Montgomery, Palma Fava, Carolyn R Freeman, Tarek Hijal, Ciro Maietta, William Parker, John Kildea
PURPOSE: Collaborative incident learning initiatives in radiation therapy promise to improve and standardize the quality of care provided by participating institutions. However, the software interfaces provided with such initiatives must accommodate all participants and thus are not optimized for the workflows of individual radiation therapy centers. This article describes the development and implementation of a radiation therapy incident learning system that is optimized for a clinical workflow and uses the taxonomy of the Canadian National System for Incident Reporting - Radiation Treatment (NSIR-RT)...
November 22, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29165864/an-australian-hospital-s-training-program-and-referral-pathway-within-a-multi-disciplinary-health-justice-partnership-addressing-family-violence
#12
Kirsty Forsdike, Cathy Humphreys, Kristin Diemer, Stuart Ross, Linda Gyorki, Helena Maher, Penelope Vye, Fleur Llewelyn, Kelsey Hegarty
OBJECTIVE: An innovative health-justice partnership was established to deliver legal assistance to women experiencing family violence who attended an Australian hospital. This paper reports on a multifaceted response to build capacity and willingness of health professionals to identify signs of family violence and engage with referral pathways to on-site legal assistance. METHODS: A Realistic Evaluation analysed health professionals' knowledge and attitudes towards identification, response and referral for family violence before and after training; and use of referral pathways...
November 22, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29165824/measurement-of-social-norms-affecting-modern-contraceptive-use-a-literature-review
#13
Elizabeth Costenbader, Rachel Lenzi, Rebecca B Hershow, Kim Ashburn, Donna R McCarraher
As a critical building block to developing social norms interventions to support healthy family planning and other reproductive health behaviors, we conducted a literature review to identify and evaluate social norm measures related to modern contraceptive use. Of 174 articles reviewed in full, only 17 studies met our criteria for inclusion. Across these articles, no single measure of norms was used in more than one study; failure to specify the boundaries of who was engaging in and influencing the behaviors of interest contributed to the variation...
November 22, 2017: Studies in Family Planning
https://www.readbyqxmd.com/read/29165813/radiation-therapy-in-retroperitoneal-sarcoma-management
#14
REVIEW
Rick L Haas, Elizabeth H Baldini, Peter W Chung, Frits van Coevorden, Thomas F DeLaney
Surgery is potentially curative for primary non-metastatic retroperitoneal soft tissue sarcomas (RPS), although patients remain at risk for local recurrence. To reduce this risk, the addition of radiotherapy to radical surgery may be considered. Nevertheless, level I evidence to support radiotherapy is currently lacking. The results from the EORTC-STBSG 62092-22092 studying this question are awaited. This manuscript addresses issues to consider when radiation-oncologists engage in a multidisciplinary treatment approach for RPS patients, including radiotherapy...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29165780/twitter-weather-warnings-communicating-risk-in-140-characters-the-impact-of-imperative-and-declarative-message-style-on-weather-risk-perception-and-behavioral-intentions
#15
Adam M Rainear, Kenneth A Lachlan, Patric R Spence
Understanding how individuals utilize risk messages is important for protecting lives and gaining compliance toward safe behaviors. Recent advances in technology afford users with timeliness when needing to acquire information, and research investigating imperative and declarative message styles suggests utilizing both strategies is most effective. Similarly, the element of time can play a role when an individual engages in certain behaviors. This study employed an experimental design to better understand how imperative and declarative tweets, and time can contribute to risk perceptions and behavioral intentions...
September 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29165682/the-silencing-of-political-context-in-health-research-in-ethiopia-why-it-should-be-a-concern
#16
Marit Tolo Østebø, Megan D Cogburn, Anjum Shams Mandani
In 2004, the Ethiopian government launched what has been called an innovative and groundbreaking solution to the country's public health challenges; the Health Extension Programme (HEP). The positive public health outcomes that have been reported following the implementation of the HEP have led researchers and global health actors to propose it as a model for other countries to emulate. In this systematic review, we point to a potential weakness and methodological bias in the existing research. Despite being implemented within a context of an increasingly authoritarian regime, research conducted following the implementation of HEP reflects a limited discussion of the political context...
November 20, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29165591/translation-can-affect-the-antisense-activity-of-rnase-h1-dependent-oligonucleotides-targeting-mrnas
#17
Xue-Hai Liang, Joshua G Nichols, Hong Sun, Stanley T Crooke
RNase H1-dependent antisense oligonucleotides (ASOs) can degrade complementary RNAs in both the nucleus and the cytoplasm. Since cytoplasmic mRNAs are actively engaged in translation, ASO activity may thus be affected by translating ribosomes that scan the mRNAs. Here we show that mRNAs associated with ribosomes can be cleaved using ASOs and that translation can alter ASO activity. Translation inhibition tends to increase ASO activity when targeting the coding regions of efficiently translated mRNAs, but not nuclear non-coding RNAs or less efficiently translated mRNAs...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165581/acquisition-persistence-and-clearance-of-human-papillomavirus-infection-among-male-virgins-residing-in-brazil-mexico-and-the-united-states
#18
Zhiyue Liu, Alan G Nyitray, Lu-Yu Hwang, Michael D Swartz, Martha Abrahamsen, Eduardo Lazcano-Ponce, Luisa L Villa, Anna R Giuliano
Background: Little is known about the natural history of HPV infection in male virgins. This study estimated incidence and clearance of genital HPV, and factors associated with HPV, among men who deny ever engaging in penetrative sex at baseline. Methods: A cohort of 4123 men residing in Brazil, Mexico, and the USA were followed every 6 months for up to 10 visits. Genital exfoliated cells were collected and genotyped for 36 HPV types. Eighty-seven men were classified as virgins and included for analysis...
November 18, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29165564/social-networks-as-a-tool-for-science-communication-and-public-engagement-focus-on-twitter
#19
Ignacio López-Goñi, Manuel Sánchez-Angulo
Social networks have been used to teach and engage people about the importance of science. The integration of social networks in the daily routines of Faculty and Scientists is strongly recommended to increase their personal brand, improve their skills, enhance their visibility, share and communicate science to society, promote scientific culture, and even as a tool for teaching and learning. Here we review the use of Twitter in Science and comment our previous experience on using this social network as a platform for a Massive Online Open Course (MOOC) in Spain and Latin America...
November 20, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29165558/-she-had-a-smile-on-her-face-as-wide-as-the-great-australian-bite-a-qualitative-examination-of-family-perceptions-of-a-therapeutic-robot-and-a-plush-toy
#20
Wendy Moyle, Marguerite Bramble, Cindy J Jones, Jenny E Murfield, Barbara J Bowers
Background and Objectives: Recent years have seen social robotic pets introduced as a means of treating behavioral and psychological symptoms of dementia, and many show promising potential. In this study, we sought to explore family members' perceptions of the Japanese-developed baby harp seal, Paro (version 9), and a look-alike, nonrobotic Plush Toy, when used by their relative with dementia for 15 min, 3 afternoons per week for 10 weeks. Research Design and Method: The study employed a descriptive qualitative approach, which was nested within a larger cluster randomized controlled trial...
November 19, 2017: Gerontologist
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