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https://www.readbyqxmd.com/read/27915463/the-our-hope-approach-for-ethics-and-communication-about-neonatal-neurological-injury
#1
REVIEW
Eric Racine, Emily Bell, Barbara Farlow, Steven Miller, Antoine Payot, Lisa Anne Rasmussen, Michael I Shevell, Donna Thomson, Pia Wintermark
Predicting neurological outcomes of neonates with acute brain injury is an essential component of shared decision-making, in order to guide the development of treatment goals and appropriate care plans. It can aid parents in imagining the child's future, and guide timely and ongoing treatment decisions, including shifting treatment goals and focusing on comfort care. However, numerous challenges have been reported with respect to evidence-based practices for prognostication such as biases about prognosis among clinicians...
December 4, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27915432/social-learning-in-a-longitudinal-integrated-clinical-placement
#2
Chris Roberts, Michele Daly, Fabian Held, David Lyle
Recent research has demonstrated that longitudinal integrated placements (LICs) are an alternative mode of clinical education to traditional placements. Extended student engagement in community settings provide the advantages of educational continuity as well as increased service provision in underserved areas. Developing and maintaining LICs require a differing approach to student learning than that for traditional placements. There has been little theoretically informed empirical research that has offered explanations of which are the important factors that promote student learning in LICs and the relationships between those factors...
December 3, 2016: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/27915416/opposing-effects-on-the-cell-cycle-of-t-lymphocytes-by-fbxo7-via-cdk6-and-p27
#3
Shachi P Patel, Suzanne J Randle, Sarah Gibbs, Anne Cooke, Heike Laman
G1 phase cell cycle proteins, such as cyclin-dependent kinase 6 (Cdk6) and its activating partners, the D-type cyclins, are important regulators of T-cell development and function. An F-box protein, called F-box only protein 7 (Fbxo7), acts as a cell cycle regulator by enhancing cyclin D-Cdk6 complex formation and stabilising levels of p27, a cyclin-dependent kinase inhibitor. We generated a murine model of reduced Fbxo7 expression to test its physiological role in multiple tissues and found that these mice displayed a pronounced thymic hypoplasia...
December 3, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27915378/mother-infant-interactions-and-regional-brain-volumes-in-infancy-an-mri-study
#4
Vaheshta Sethna, Inês Pote, Siying Wang, Maria Gudbrandsen, Anna Blasi, Caroline McCusker, Eileen Daly, Emily Perry, Kerrie P H Adams, Maria Kuklisova-Murgasova, Paula Busuulwa, Sarah Lloyd-Fox, Lynne Murray, Mark H Johnson, Steven C R Williams, Declan G M Murphy, Michael C Craig, Grainne M McAlonan
It is generally agreed that the human brain is responsive to environmental influences, and that the male brain may be particularly sensitive to early adversity. However, this is largely based on retrospective studies of older children and adolescents exposed to extreme environments in childhood. Less is understood about how normative variations in parent-child interactions are associated with the development of the infant brain in typical settings. To address this, we used magnetic resonance imaging to investigate the relationship between observational measures of mother-infant interactions and regional brain volumes in a community sample of 3- to 6-month-old infants (N = 39)...
December 3, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27915225/development-of-a-novel-virtual-reality-gait-intervention
#5
Anna E Boone, Matthew H Foreman, Jack R Engsberg
INTRODUCTION: Improving gait speed and kinematics can be a time consuming and tiresome process. We hypothesize that incorporating virtual reality videogame play into variable improvement goals will improve levels of enjoyment and motivation and lead to improved gait performance. PURPOSE: To develop a feasible, engaging, VR gait intervention for improving gait variables. METHODS: Completing this investigation involved four steps: 1) identify gait variables that could be manipulated to improve gait speed and kinematics using the Microsoft Kinect and free software, 2) identify free internet videogames that could successfully manipulate the chosen gait variables, 3) experimentally evaluate the ability of the videogames and software to manipulate the gait variables, and 4) evaluate the enjoyment and motivation from a small sample of persons without disability...
November 14, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27915153/room-temperature-structure-of-human-igg4-fc-from-crystals-analysed-in-situ
#6
Anna M Davies, Theo Rispens, Pleuni Ooijevaar-de Heer, Rob C Aalberse, Brian J Sutton
The Fc region of IgG antibodies (Cγ2 and Cγ3 domains) is responsible for effector functions such as antibody-dependent cell-mediated cytotoxicity and phagocytosis, through engagement with Fcγ receptors, although the ability to elicit these functions differs between the four human IgG subclasses. A key determinant of Fcγ receptor interactions is the FG loop in the Cγ2 domain. High resolution cryogenic IgG4-Fc crystal structures have revealed a unique conformation for this loop, which could contribute to the particular biological properties of this subclass...
December 1, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27915122/effects-of-a-training-in-mental-imagery-on-worry-a-proof-of-principle-study
#7
Timo Skodzik, Alexandra Leopold, Thomas Ehring
Worry is characterized by a predominance of verbal thinking and relatively little mental imagery. This cognitive bias of verbal and abstract processing has been found to impair emotional processing of worry topics so that worrisome thoughts are maintained. On the other hand, engaging in mental imagery during the worry process fosters emotional processing of worry themes. In the present study, we examined whether training high worriers (n=71) to use more mental imagery in their everyday lives is an effective intervention to reduce pathological worry...
November 25, 2016: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/27914915/physical-activity-modifies-the-association-between-dietary-protein-and-lean-mass-of-postmenopausal-women
#8
Jessica A Martinez, Betsy C Wertheim, Cynthia A Thomson, Jennifer W Bea, Robert Wallace, Matthew Allison, Linda Snetselaar, Zhao Chen, Rami Nassir, Patricia A Thompson
BACKGROUND: Maintenance of lean muscle mass and related strength is associated with lower risk for numerous chronic diseases of aging in women. OBJECTIVE: Our aim was to evaluate whether the association between dietary protein and lean mass differs by physical activity level, amino acid composition, and body mass index categories. DESIGN: We performed a cross-sectional analysis of a prospective cohort. PARTICIPANTS/SETTING: Participants were postmenopausal women from the Women's Health Initiative with body composition measurements by dual-energy x-ray absorptiometry (n=8,298)...
November 30, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27914861/rapid-human-immunodeficiency-virus-testing-and-risk-prevention-in-residents-of-battered-women-s-shelters
#9
Dawn M Johnson, Nicole L Johnson, Curt G Beckwith, Patrick A Palmieri, Caron Zlotnick
BACKGROUND: Human immunodeficiency virus (HIV) infection and intimate partner violence (IPV) are interconnected public health problems. However, few HIV prevention interventions address the unique needs of IPV survivors in shelter and none of the Centers for Disease Control and Prevention's best-evidence risk reduction interventions adequately explore the complex relationship between IPV and HIV risk. Although battered women's shelters provide a safe and supportive environment for women in crisis, most do not offer HIV risk reduction services or sexual safety planning...
November 30, 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/27914734/applying-a-deliberation-model-to-the-analysis-of-consultations-in-haemophilia-implications-for-doctor-patient-communication
#10
Giulia Lamiani, Sarah Bigi, Maria Elisa Mancuso, Antonio Coppola, Elena Vegni
OBJECTIVE: Literature highlights the importance of communication in order to achieve patient's adherence. However, the specific dialogical components likely to favor patient adherence are not clear. In this study, the deliberation dialogue model was applied as an ideal model of optimal deliberation to real physician-patient consultations in the field of hemophilia in order to identify misalignments with the model and possible improvements in physician-patient communication. METHODS: By applying the deliberation model, we analyzed a corpus of 30 check-up consultations in hemophilia...
November 28, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27914357/moving-toward-heutagogical-learning-illuminating-undergraduate-nursing-students-experiences-in-a-flipped-classroom
#11
Rebecca D Green, Maura C Schlairet
BACKGROUND: Nurse educators rely on the tenets of educational theory and evidence-based education to promote the most effective curriculum and facilitate the best outcomes. The flipped classroom model, in which students assume personal responsibility for knowledge acquisition in a highly engaging and interactive environment, supports self-directed learning and the unique needs of clinical education. OBJECTIVE: To understand how students perceived their experiences in the flipped classroom and how students' learning dispositions were affected by the flipped classroom experience...
November 25, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27914356/can-podcasts-for-assessment-guidance-and-feedback-promote-self-efficacy-among-undergraduate-nursing-students-a-qualitative-study
#12
Linda C McSwiggan, Maureen Campbell
BACKGROUND: Improving assessment guidance and feedback for students has become an international priority within higher education. Podcasts have been proposed as a tool for enhancing teaching, learning and assessment. However, a stronger theory-based rationale for using podcasts, particularly as a means of facilitating assessment guidance and feedback, is required. OBJECTIVE: To explore students' experiences of using podcasts for assessment guidance and feedback...
November 27, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27914318/older-adults-attentional-deployment-differential-gaze-patterns-for-different-negative-mood-states
#13
Ineke Demeyer, Alvaro Sanchez, Rudi De Raedt
BACKGROUND AND OBJECTIVES: Older adults are characterized by an attentional preference for positive over negative information. Since this positivity effect is considered to be an emotion regulation strategy, it should be more pronounced when emotion regulation is needed. In contrast to previous studies that focused on the effects of sad mood on attention, we used a stressor to activate emotion regulation and evaluate the effects of different types of mood state changes. Moreover, we evaluated mood effects on attentional processes using a paradigm that allows disentangling between different attentional engagement and disengagement processes...
November 24, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27914311/stepwatch-accuracy-during-walking-running-and-intermittent-activities
#14
Lindsay P Toth, David R Bassett, Scott E Crouter, Brittany S Overstreet, Samuel R LaMunion, Susan Park, Shahnawaz N Notta, Cary M Springer
INTRODUCTION: The purpose of this study was two-fold: 1) to investigate effects of cadence and sensitivity settings for the StepWatch (SW3) on step count accuracy over a wide range of ambulatory speeds, and 2) to compare the preprogrammed "quick start" settings to modified settings during intermittent lifestyle activities. METHODS: Part 1: Fifteen participants (18-57 years of age) performed two trials of treadmill walking and running at ten speeds ranging from 26...
November 21, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27914239/sixth-graders-in-israel-recount-their-experience-of-verbal-abuse-by-teachers-in-the-classroom
#15
Brenda Geiger
AIM: This study adopts a children's rights perspective stated in Articles 3, 12, 19, 28 of the Convention on the Rights of Children (1989) with the goal of listening to Israeli children articulate their experience of verbal abuse by teachers in 6th grade classrooms METHODS: A purposeful sample of sixty students was individually interviewed and content analysis was performed following Strauss' (1987) constant comparative method. RESULTS: Students reported teachers' yelling, name-calling and put-downs when failing to pay attention, complete their work, or obtain good grades...
November 30, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27914226/drinking-motives-and-alcohol-outcome-expectancies-as-mediators-of-the-association-between-negative-urgency-and-alcohol-consumption
#16
Amber M Anthenien, Jordanna Lembo, Clayton Neighbors
OBJECTIVE: To determine whether the effects of negative urgency, a unique facet of impulsivity marked by engaging in potentially unhealthy and rash behaviors in order to cope with anxiety or negative moods, on drinking behavior can be explained by positive and negative alcohol outcome expectancies and specific drinking motives (i.e., coping and enhancement). METHODS: College students (N=194) completed web-based surveys in exchange for course credit. Students completed measures of negative urgency, comprehensive effects of alcohol, drinking motives, and alcohol use behaviors...
November 15, 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/27914116/so-it-is-so-it-shall-be-group-regularities-license-children-s-prescriptive-judgments
#17
Steven O Roberts, Susan A Gelman, Arnold K Ho
When do descriptive regularities (what characteristics individuals have) become prescriptive norms (what characteristics individuals should have)? We examined children's (4-13 years) and adults' use of group regularities to make prescriptive judgments, employing novel groups (Hibbles and Glerks) that engaged in morally neutral behaviors (e.g., eating different kinds of berries). Participants were introduced to conforming or non-conforming individuals (e.g., a Hibble who ate berries more typical of a Glerk)...
December 3, 2016: Cognitive Science
https://www.readbyqxmd.com/read/27914017/mothers-fathers-and-parental-systems-a-conceptual-model-of-parental-engagement-in-programmes-for-child-mental-health-connect-attend-participate-enact-cape
#18
Patrycja J Piotrowska, L A Tully, R Lenroot, E Kimonis, D Hawes, C Moul, P J Frick, V Anderson, M R Dadds
Parenting programmes are one of the best researched and most effective interventions for reducing child mental health problems. The success of such programmes, however, is largely dependent on their reach and parental engagement. Rates of parental enrolment and attendance are highly variable, and in many cases very low; this is especially true of father involvement in parenting programmes. This paper proposes a conceptual model of parental engagement in parenting programmes-the CAPE model (Connect, Attend, Participate, Enact) that builds on recent models by elaborating on the interdependent stages of engagement, and its interparental or systemic context...
December 2, 2016: Clinical Child and Family Psychology Review
https://www.readbyqxmd.com/read/27913990/sirukumab-a-potential-treatment-for-mood-disorders
#19
REVIEW
Aileen J Zhou, Yena Lee, Giacomo Salvadore, Benjamin Hsu, Trehani M Fonseka, Sidney H Kennedy, Roger S McIntyre
Convergent evidence indicates that abnormalities in the innate immune system may be pertinent to the pathogenesis, phenomenology, and possible treatment of several mental disorders. In keeping with this view, the targeting of interleukin-6 with the human monoclonal antibody sirukumab may represent a possible treatment and disease modification approach, for adults with brain-based disorders (e.g., major depressive disorder). A PubMed/Medline database search was performed using the following search terms: sirukumab; anti-IL-6; IL-6; major depressive disorder; inflammation...
December 2, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27913907/development-of-a-culturally-informed-child-safety-curriculum-for-american-indian-families
#20
Ryan M Berns, Emily J Tomayko, Kate A Cronin, Ronald J Prince, Tassy Parker, Alexandra K Adams
American Indian (AI) children are disproportionately affected by unintentional injuries, with injury mortality rates approximately 2.3 times higher than the combined rates for all children in the United States. Although multiple risk factors are known to contribute to these increased rates, a comprehensive, culturally informed curriculum that emphasizes child safety is lacking for this population. In response to this need, academic and tribal researchers, tribal community members, tribal wellness staff, and national child safety experts collaborated to develop a novel child safety curriculum...
December 2, 2016: Journal of Primary Prevention
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