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https://www.readbyqxmd.com/read/29708315/glypican-3-and-melanoma-antigen-genes-1-and-3-as-tumor-markers-for-hepatocellular-carcinoma
#1
Nadia M El-Wahab, Hebat-Allah G Rashed, Wafaa T El-Sherif, Sohair K Sayed, Mohamed O Abd-Elmalek, Abeer Refaiy, Hussein Fakhry, Abeer A Mokhtar
Hepatocellular carcinoma (HCC) is the commonest liver cancer; its incidence and prevalence are continuously increased. Glypican3 (GPC3), melanoma antigen-1, 3 genes (MAGE1 and 3) are tumor markers used in HCC. We evaluated their role in HCC detection and assessed their relation to tumor parameters. Three groups, HCC group, liver cirrhosis group and a control group were studied. AFP, GPC3, and MAGE1 and 3 mRNA were determined in all study subjects. Tissue GPC3 was examined in patients with HCC only. Serum AFP and GPC3 were elevated in HCC group compared to other groups (P < 0...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29675356/-in-vivo-fluorescence-imaging-of-hepatocellular-carcinoma-using-a-novel-gpc3-specific-aptamer-probe
#2
Menglong Zhao, Lili Dong, Zhuang Liu, Shuohui Yang, Weizhong Wu, Jiang Lin
Background: Glypican-3 (GPC3) is highly expressed in most of the hepatocellular carcinomas (HCCs), even in small HCCs. It may be used as a potential biomarker for early detection of HCC. The aptamer is a promising targeting agent with unique advantages over antibody. This study was to introduce a novel GPC3 specific aptamer (AP613-1), to verify its specific binding property in vitro , and to evaluate its targeting efficiency in vivo by performing near-infrared (NIR) fluorescence imaging on an HCC xenograft model...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29652239/ovotesticular-disorder-of-sex-development-ovotestis-in-simpson-golabi-behmel-syndrome-expansion-of-the-clinical-spectrum
#3
Monique E De Paepe, Lawrence Young, Julie R Jones, Umadevi Tantravahi
Simpson-Golabi-Behmel syndrome type I (SGBS, OMIM312870), caused by defects of the GPC3 and GPC4 genes on chromosome Xq26, is an X-linked recessive macrosomia/multiple congenital anomaly disorder characterized by somatic overgrowth, coarse facial features, variable congenital anomalies, increased tumor risk, and mild-to-moderate neurodevelopmental anomalies. We report the postmortem findings in 3 second-trimester male siblings with SGBS who displayed ambiguous genitalia (in all 3) and gonadal dysgenesis (ovotestis) (in 1), thus expanding the SGBS spectrum to include these disorders of sex development...
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29623600/significance-of-glypican-3-in-early-detection-of-hepatocellular-carcinoma-in-cirrhotic-patients
#4
Ahmed M Tahon, Magdy Z El-Ghanam, Samy Zaky, Tarek Mostafa Emran, Ali M Bersy, Fathiya El-Raey, Elsayed A Z, Amr M El Kharsawy, Dina Johar
BACKGROUND: Egypt has high incidence of hepatocellular carcinoma (HCC). This is due to wide spread of hepatitis C virus (HCV) infection which is responsible for most of the cases of liver cirrhosis. The major diagnostic techniques for HCC include serum markers and various imaging modalities. Glypican 3 (GPC3) protein is highly expressed in HCC, but not in normal liver tissue. The significance of GPC3 as a predictor or diagnostic tool for human tumors other than HCC is unclear. AIM: To quantitatively assess the role of GPC3 in diagnosis of HCC in comparison to α-fetoprotein (AFP), ultrasonography (US), and computerized tomography (CT)...
April 6, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29577937/hepatitis-c-virus-hcv-mimics-effects-of-glypican-3-gpc3-on-cd81-and-promotes-development-of-hepatocellular-carcinomas-via-activation-of-hippo-pathway-in-hepatocytes
#5
Yuhua Xue, Wendy M Mars, William Bowen, Aatur D Singhi, John Stoops, George K Michalopoulos
Glypican 3 (GPC3) is over-expressed in hepatocellular carcinomas (HCC). GPC3 binds to CD81. Forced expression of CD81 in a GPC3 expressing HCC cell line caused activation of Hippo, decrease in Ezrin phosphorylation, and decrease in Yap. CD81 is also associated with HCV entry into hepatocytes. Activation of CD81 by agonistic antibody causes activation of spleen kinase (Syk) and phosphorylation of Ezrin, a regulator of Hippo pathway. In cultures of normal hepatocytes, CD81 agonistic antibody led to enhanced phosphorylation of Ezrin and increase in nuclear Yap...
March 22, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29569872/concomitant-use-of-heat-shock-protein-70-glutamine-synthetase-and-glypican-3-is-useful-in-diagnosis-of-hbv-related-hepatocellular-carcinoma-with-higher-specificity-and-sensitivity
#6
Bita Moudi, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Seyed-Moayed Alavian, Kamran B Lankarani, Parisa Farrokh, Jens Randel Nyengaard
Hepatocellular carcinoma is the third leading cause of cancer-related death worldwide and late diagnosis is the main cause of death in HCC patients. In this study expression patterns of HSP70, GPC3 and GS and their relationships with pathogenesis of HCC in Iranian patients were investigated. The expression of HSP70, GPC3 and GS were determined by immunohistochemistry and quantitative real-time PCR (q-PCR) methods, using 121 cases from patients with HBV alone, HCC without HBV, HBV+HCC and 30 normal tissues as control group...
January 29, 2018: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29563582/evaluation-of-the-glypican-3-promoter-for-transcriptional-targeting-of-hepatocellular-carcinoma
#7
Bijay Dhungel, Slawomir Andrzejewski, Aparna Jayachandran, Ritu Shrestha, Charmaine A Ramlogan-Steel, Christopher J Layton, Jason C Steel
Hepatocellular carcinoma (HCC) is a major health problem as evidenced by its increasing incidence and high morbidity and mortality rates. Most patients with HCC have underlying liver disease and dysfunction which limits the current therapeutic options. Treatments that spare the liver and destroy the HCC are needed. Targeting transcriptional differences between HCC and liver cells may provide this therapeutic window. In this study, we examine the potential of the Glypican 3 (GPC3) promoter as a targeting strategy...
March 21, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29561231/polyclonal-antibody-production-against-rgpc3-and-their-application-in-diagnosis-of-hepatocellular-carcinoma
#8
Shenghao Wang, Muhammad Kalim, Keying Liang, Jinbiao Zhan
Glypican-3 (GPC3) is an integral membrane proteoglycan, which contains a core protein anchored to the cytoplasmic membrane through a glycosyl phosphatidylinositol linkage. The glypican-3 can regulate the signaling pathways, thereby enhances cell division, growth, and apoptosis in certain cell types. It is almost non-existent on the surface of the human normal cell membrane and highly expresses on the membrane of hepatocellular carcinoma (HCC) cells. It has been well established that GPC3 provide a useful diagnostic marker...
March 21, 2018: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/29535817/combining-expression-of-gpc3-in-tumors-and-cd16-on-nk-cells-from-peripheral-blood-to-identify-patients-responding-to-codrituzumab
#9
Gong Chen, Ya-Chi Chen, Bernhard Reis, Anton Belousov, Lori Jukofsky, Christine Rossin, Axel Muehlig, Chao Xu, Laurent Essioux, Toshihiko Ohtomo, Laura Di Laurenzio, Oscar Puig, Ray Lee
Background: Codrituzumab, a monoclonal antibody targeting an oncofetal protein glypican-3 (GPC3) expressed on cell surface of hepatocellular carcinoma (HCC) induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth in preclinical studies. Based on this mechanism, tumor GPC3 expression and CD16 expression on NK cells, which are the effector cells of ADCC, were investigated to correlate with codrituzumab's clinical efficacy in patients with advanced HCC. Results: Joint analyses of the two biomarkers revealed that both high levels of GPC3 and CD16 were required for patients to benefit from codrituzumab; lack of either one of them would lead to a loss of the therapeutic effect...
February 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29521467/dual-selective-and-dual-enhanced-sers-nanoprobes-strategy-for-circulating-hepatocellular-carcinoma-cells-detection
#10
Yuanfeng Pang, Chongwen Wang, Rui Xiao, Zhiwei Sun
The detection of hepatocellular carcinoma (HCC) circulating tumor cells (CTCs) from a blood sample can be a very powerful noninvasive approach for the early detection and therapy of liver cancer. However, the extreme rarity of tumor cells in blood containing billions of other cells makes the capture and identification of CTCs with sufficient sensitivity and specificity a real challenge. Here, a magnetically assisted surface-enhanced Raman scattering (SERS) biosensor for HCC CTC detection is reported for the first time...
May 11, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29480877/hepatoblastoma-with-pure-fetal-epithelial-differentiation-in-a-10-year-old-boy-a-rare-case-report-and-review-of-the-literature
#11
REVIEW
Shanshan Zhong, Yang Zhao, Chuifeng Fan
RATIONALE: Hepatoblastoma is a rare malignant embryonal tumor that only accounts for approximately 1% of all pediatric cancers and mostly develops in children younger than 5 years old. Moreover, the occurrence of hepatoblastoma in adults is extremely rare. PATIENT CONCERNS: Herein, we present a rare case of hepatoblastoma with pure epithelial differentiation in a 10-year-old boy.Pathological examination was performed. The tumor was 15 cm × 15 cm in size with clear margins...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29398870/low-glucose-metabolism-in-hepatocellular-carcinoma-with-gpc3-expression
#12
You-Cai Li, Chuan-Sheng Yang, Wen-Lan Zhou, Hong-Sheng Li, Yan-Jiang Han, Quan-Shi Wang, Hu-Bing Wu
AIM: To investigate the relationship between glucose metabolism and glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC). METHODS: Immunohistochemical staining of pathological samples for GPC3 and glucose transporter 1 (GLUT1), and whole-body 18 F-FDG PET/CT for measuring tumour glucose uptake were performed in 55 newly diagnosed HCC patients. The maximum standard uptake value (SUVmax ) and tumour-to-non-tumourous liver uptake (T/NT) ratio were used to quantify 18 F-FDG uptake...
January 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29397868/sf3b4-as-an-early-stage-diagnostic-marker-and-driver-of-hepatocellular-carcinoma
#13
Qingyu Shen, Suk Woo Nam
An accurate diagnostic marker for detecting early-stage hepatocellular carcinoma (eHCC) is clinically important, since early detection of HCC remarkably improves patient survival. From the integrative analysis of the transcriptome and clinicopathologic data of human multi-stage HCC tissues, we were able to identify barrier-to-autointegration factor 1 (BANF1), procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) and splicing factor 3b subunit 4 (SF3B4) as early HCC biomarkers which could be detected in precancerous lesions of HCC, with superior capabilities to diagnose eHCC compared to the currently popular HCC diagnostic biomarkers: GPC3, GS, and HSP70...
February 2018: BMB Reports
https://www.readbyqxmd.com/read/29391759/multi-parameter-gene-expression-profiling-of-peripheral-blood-for-early-detection-of-hepatocellular-carcinoma
#14
Hui Xie, Yao-Qin Xue, Peng Liu, Peng-Jun Zhang, Sheng-Tao Tian, Zhao Yang, Zhi Guo, Hua-Ming Wang
AIM: In our previous study, we have built a nine-gene ( GPC3 , HGF , ANXA1 , FOS , SPAG9 , HSPA1B , CXCR4 , PFN1 , and CALR ) expression detection system based on the GeXP system. Based on peripheral blood and GeXP, we aimed to analyze the results of genes expression by different multi-parameter analysis methods and build a diagnostic model to classify hepatocellular carcinoma (HCC) patients and healthy people. METHODS: Logistic regression analysis, discriminant analysis, classification tree analysis, and artificial neural network were used for the multi-parameter gene expression analysis method...
January 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29381229/time-to-event-modelling-of-effect-of-codrituzumab-on-overall-survival-in-patients-with-hepatocellular-carcinoma
#15
Mikiko Nakamura, Chao Xu, Cheikh Diack, Norihisa Ohishi, Ruey-Min Lee, Satofumi Iida, Takehiko Kawanishi, Toshihiko Ohtomo, Ghassan K Abou-Alfa, Ya-Chi Chen
AIMS: Codrituzumab (GC33) is a recombinant, humanized mAb that binds to glypican-3 (GPC3), an oncofetal protein highly expressed in hepatocellular carcinoma (HCC). This investigation aimed to identify clinically relevant factors that may affect the overall survival (OS) in HCC patients treated with codrituzumab and to quantitatively annotate their effects. METHODS: Codrituzumab exposure was estimated by a population pharmacokinetics model with a nonlinear elimination pathway...
May 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29379301/autophagy-suppresses-proliferation-of-hepg2-cells-via-inhibiting-glypican-3-wnt-%C3%AE-catenin-signaling
#16
Pei Hu, Bin Cheng, Yulin He, Zhiqiang Wei, Dongfang Wu, Zhongji Meng
Introduction: Autophagy plays an important role in the growth and survival of hepatocellular carcinoma (HCC) cells through several target proteins or signaling pathways. Glypican-3 (GPC3) is a new reliable HCC marker, which is involved in tumor growth in HCC, primarily mediated by wnt/β-catenin signaling. Objective: The present study aimed to identify the role of autophagy in the proliferation of HepG2 cells through GPC3/wnt/β-catenin signaling. Results and discussion: Results demonstrated that induction of autophagy by nutrition starvation and rapamycin treatment led to the downregulation of GPC3 expression in HepG2 cells, accompanied by the decreased expression of wnt downstream target genes (β-catenin, c-myc and cyclin D1)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29369198/prognostic-significance-of-glypican-3-expression-in-hepatocellular-carcinoma-a-meta-analysis
#17
Hong Liu, Chunmei Yang, Wenzhu Lu, Yong Zeng
BACKGROUND: In recent years, an increasing number of studies has been published analyzing the possible prognostic utility of glypican-3 (GPC3) in hepatocellular carcinoma (HCC), but the results are still controversial. The aim of this meta-analysis was to evaluate possible association between GPC3 expression and patients' survival. METHODS: Relevant publications which assessed GPC3 expression with survival outcome in HCC patients were searched from Pubmed, Embase, Web of Science, and the Cochrane library...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29345911/role-of-glycanation-and-convertase-maturation-of-soluble-glypican-3-in-inhibiting-proliferation-of-hepatocellular-carcinoma-cells
#18
Ahmad Saad, Benjamin Liet, Gilles Joucla, Xavier Santarelli, Justine Charpentier, Stéphane Claverol, Christophe F Grosset, Véronique Trézéguet
Glypican 3 (GPC3) is a complex heparan sulfate proteoglycan associated with the outer surface of the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is also N-glycosylated and processed by a furin-like convertase. GPC3 has numerous biological functions. Although GPC3 is undetectable in normal liver tissue, it is abnormally and highly overexpressed in hepatocellular carcinoma (HCC). Interestingly, proliferation of HCC cells such as HepG2 and HuH7 is inhibited when they express a soluble form of GPC3 after lentiviral transduction...
February 20, 2018: Biochemistry
https://www.readbyqxmd.com/read/29339014/development-of-gpc3-specific-chimeric-antigen-receptor-engineered-natural-killer-cells-for-the-treatment-of-hepatocellular-carcinoma
#19
Min Yu, Hong Luo, Mingliang Fan, Xiuqi Wu, Bizhi Shi, Shengmeng Di, Ying Liu, Zeyan Pan, Hua Jiang, Zonghai Li
Chimeric antigen receptor (CAR)-modified natural killer (NK) cells represent a promising immunotherapeutic modality for cancer treatment. However, their potential utilities have not been explored in hepatocellular carcinoma (HCC). Glypian-3 (GPC3) is a rational immunotherapeutic target for HCC. In this study, we developed GPC3-specific NK cells and explored their potential in the treatment of HCC. The NK-92/9.28.z cell line was established by engineering NK-92, a highly cytotoxic NK cell line with second-generation GPC3-specific CAR...
February 7, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29259231/a-novel-cell-line-based-orthotopic-xenograft-mouse-model-that-recapitulates-human-hepatoblastoma
#20
Sarah E Woodfield, Yan Shi, Roma H Patel, Jingling Jin, Angela Major, Stephen F Sarabia, Zbigniew Starosolski, Barry Zorman, Siddharth S Gupta, Zhenghu Chen, Aryana M Ibarra, Karl-Dimiter Bissig, Ketan B Ghaghada, Pavel Sumazin, Dolores López-Terrada, Sanjeev A Vasudevan
Currently, preclinical testing of therapies for hepatoblastoma (HB) is limited to subcutaneous and intrasplenic xenograft models that do not recapitulate the hepatic tumors seen in patients. We hypothesized that injection of HB cell lines into the livers of mice would result in liver tumors that resemble their clinical counterparts. HepG2 and Huh-6 HB cell lines were injected, and tumor growth was monitored with bioluminescence imaging (BLI) and magnetic resonance imaging (MRI). Levels of human α-fetoprotein (AFP) were monitored in the serum of animals...
December 19, 2017: Scientific Reports
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