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https://www.readbyqxmd.com/read/29054076/genetic-polymorphisms-in-angiogenesis-related-genes-are-associated-with-worse-progression-free-survival-of-patients-with-advanced-gastrointestinal-stromal-tumours-treated-with-imatinib
#1
Michiel C Verboom, Jacqueline S L Kloth, Jesse J Swen, Tahar van der Straaten, Judith V M G Bovée, Stefan Sleijfer, Anna K L Reyners, Ron H J Mathijssen, Henk-Jan Guchelaar, Neeltje Steeghs, Hans Gelderblom
BACKGROUND: Imatinib 400 mg per day is first-line therapy for patients with gastrointestinal stromal tumours (GISTs). Although clinical benefit is high, progression-free survival (PFS) is variable. This study explores the relationship of single nucleotide polymorphisms (SNPs) in genes related to imatinib pharmacokinetics and pharmacodynamics and PFS in imatinib-treated patients with advanced GIST. METHODS: In 227 patients a pharmacogenetic pathway analysis was performed...
October 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29054065/investigating-desorption-during-ethanol-elution-to-improve-the-quality-and-antioxidant-activity-of-xylo-oligosaccharides-from-corn-stalk
#2
Jie Zhang, Yue-Hai Wang, Quan-Yuan Wei, Xiao-Jia Du, Yong-Shui Qu
As the most representative of lignocellulosic materials, corn stalk (CS) will be a great candidate to produce xylo-oligosaccharides (XOS). Owing to the high impurity content of the XOS produced by directly enzymatic hydrolysis of xylan extracted from CS, subsequent refining steps are essential. The present study was aimed to investigate desorption during ethanol elution to improve the quality and antioxidant activity of XOS from CS. The desorption was systematically investigated after optimizing the elution conditions...
October 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29054057/removing-ethinylestradiol-from-wastewater-by-microalgae-mutant-chlorella-py-zu1-with-co2-fixation
#3
Jun Cheng, Qing Ye, Ke Li, Jianzhong Liu, Junhu Zhou
Removal of endocrine-disrupting chemical ethinylestradiol (EE2) from wastewater by microalgal mutant Chlorella PY-ZU1 under 15% CO2 were investigated. Moreover, the effects of EE2 on microscopic structure and antioxidation ability of microalgal cells were determined. EE2 concentrations in range of 0.01-5 mg L(-1) stimulated microalgal growth. Increasing the original EE2 concentration from 0 to 5 mg L(-1) increased the cell fractal dimension from 1.38 to 1.59 and reduced the cell size from 5.18 to 3...
October 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29053944/investigation-of-the-3-epi-25-oh-d3-of-25-hydroxyvitamin-d3-in-urban-schoolchildren
#4
Samantha E Berger, Maria I Van Rompay, Catherine M Gordon, Elizabeth Goodman, Misha Eliasziw, Michael F Holick, Jennifer M Sacheck
BACKGROUND: The physiological relevance C-3 epimer of 25-hydroxyvitamin D [3-epi-25(OH)D] is not well understood among youth. OBJECTIVE: To assess whether demographic/physiologic characteristics were associated with 3-epi-25(OH)D3 concentrations in youth. METHODS: Associations between 3-epi-25(OH)D3 and demographics, 3-epi-25(OH)D3, total 25-hydroxyvitamin (25(OH)D) (25(OH)D2 + 25(OH)D3), total cholesterol, HDL, LDL and triglycerides were examined in racially/ethnically diverse schoolchildren (n=682, 8-15yrs) at Boston-area urban schools...
October 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29053935/capsaicin-the-pungent-principle-of-peppers-ameliorates-alcohol-induced-acute-liver-injury-in-mice-via-modulation-of-matrix-metalloproteinases
#5
Meghana Koneru, Bidya Dhar Sahu, Salma Mukhtar Mir, Halley Gora Ravuri, Madhusudana Kuncha, Jerald Mahesh Kumar, Eswar Kumar Kilari, Ramakrishna Sistla
Alcohol, the most common cause for hepatic injury, may further deteriorate the hepatic tissue when left unattended. Capsaicin, the pungent principle of chilli-peppers, possesses antioxidant and anti-inflammatory properties and is a proven dietary antioxidant in various ailments. However, its role in alcohol induced hepatic injury is unclear. In this study, we investigated the effects of capsaicin on the hepatic tissue of mice treated with alcohol. Acute liver injury was induced in mice by oral gavage of 5 doses of 10 ml/kg of 50% ethyl alcohol at an interval of 12 hours each...
October 20, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29053933/chronic-administration-of-ellagic-acid-improved-the-cognition-in-male-middle-aged-overweight
#6
Ying Liu, Shuyi Yu, Fen Wang, Haitao Yu, Xueli Li, Wanru Dong, Ruichao Lin, Qingshan Liu
This study aims to investigate whether ellagic acid has beneficial effects on cognitive deficits in middle-aged overweight individuals and the possible mechanism. A total of 150 middle-aged male participants, including 76 normal weight and 74 overweight, aged between 45 to 55 years were recruited for this study. Both normal weight and overweight participants were administered either 50 mg ellagic acid or placebo cellulose daily for 12 weeks. Blood lipids, peripheral brain-derived neurotrophic factor (BDNF) and saliva cortisol were assessed on the last day of the procedure to investigate the effects induced by ellagic acid...
October 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29053931/removal-of-cu-ii-in-water-by-polymer-enhanced-ultrafiltration-influence-of-polymer-nature-and-ph
#7
Olga D Kochkodan, Viktor M Kochkodan, Virender K Sharma
This study presents an efficient removal of Cu(II) in water using the polymer enhanced ultrafiltration (PEUF) method. Polymer of different molecular weight (MW) (polyethyleneimine (PEI), sodium lignosulfonates (SLS) and dextrans) were investigated to evaluate efficiency in removal of Cu(II) in water by the PEUF method. The decomposition of Cu(II)-polymer complex was also evaluated in order to reuse polymers. Cu(II) complexation depends on the MW of chelating polymer and the pH of feed solution. It was found that the Cu(II) rejection increased with the polymer dosage with high removal of Cu(II) when using PEI and SLS at a 10:20 (mg/mg) ratio ([Cu(II)]:[polymer])...
October 20, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29053918/active-site-interactions-impact-phosphoryl-transfer-during-replication-of-damaged-and-undamaged-dna-by-escherichia-coli-dna-polymerase-i
#8
A S Prakasha Gowda, Thomas E Spratt
Replicative DNA polymerases are able to discriminate between very similar substrates with high accuracy. One mechanism by which Escherichia coli DNA polymerase I checks for Watson-Crick geometry is through a hydrogen bonding fork between Arg668 and the incoming dNTP and the minor groove of the primer terminus. The importance of the Arg-fork was examined by disrupting it with either a guanine to 3-deazaguanine substitution at the primer terminus or the use of a carbocyclic deoxyribose analog of dUTP. Using thio-substituted dNTPs and differential quench techniques, we determined that when the Arg-fork was disrupted, the rate limiting step changed from a conformational change to phosphodiester bond formation...
October 20, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29053916/in-situ-wrapping-si-nanoparticles-with-2d-carbon-nanosheets-as-high-areal-capacity-anode-for-lithium-ion-batteries
#9
Lijing Yan, Jie Liu, Qianqian Wang, Minghao Sun, Zhanguo Jiang, Chengdu Liang, Feng Pan, Zhan Lin
Silicon (Si) has aroused great interest as the most promising anode material for high-energy-density lithium-ion batteries (LIBs) in the last decade because of its significantly high capacity and low discharge potential. However, its practical application is still hindered by large volume change of Si during cycling, which is more serious in the case of high mass loading. Designing Si anode with high mass loading and high areal capacity by a simple, scalable, and environmentally friendly method is still a big challenge...
October 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29053910/a-simplified-protocol-using-rituximab-and-immunoglobulin-for-abo-incompatible-low-titer-living-donor-liver-transplantation
#10
Seong Hoon Kim, Eung Chang Lee, Jae Ryong Shim, Sang Jae Park
BACKGROUND & AIMS: No consensus has been reached regarding optimal treatment strategies for ABO-incompatible (ABO-I) living donor liver transplantation (LDLT). We introduce a simplified protocol using rituximab and intravenous immunoglobulin (IVIG). METHODS: Data were analyzed on adult patients who underwent ABO-I LDLT of which protocol added rituximab (300 mg/m(2) ) before surgery and IVIG (0.8 g/kg) on postoperative days 1 and 4 to the conventional immunosuppressive regimen used in ABO-compatible (ABO-C) LDLT, without plasmapheresis, splenectomy, or graft local infusion...
October 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29053883/pharmacokinetics-of-inorganic-cobalt-and-a-vitamin-b12-supplement-in-the-thoroughbred-horse-differentiating-cobalt-abuse-from-supplementation
#11
L L Hillyer, Z Ridd, S Fenwick, P Hincks, S W Paine
BACKGROUND: Whilst cobalt is an essential micronutrient for vitamin B12 synthesis in the horse, at supra-physiological concentrations it has been shown to enhance performance in humans and rats and there is evidence that its administration in high doses to horses poses a welfare threat. Animal sport regulators currently control cobalt abuse via international race day thresholds, but since cobalt may be present in physiological concentrations this work was initiated to explore means of potentially adding to application of those thresholds...
October 20, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29053876/blood-hematological-and-biochemical-constituents-antioxidant-enzymes-immunity-and-lymphoid-organs-of-broiler-chicks-supplemented-with-propolis-bee-pollen-and-mannan-oligosaccharides-continuously-or-intermittently
#12
Y A Attia, H Al-Khalaifah, M S Ibrahim, A E Abd Al-Hamid, M A Al-Harthi, A El-Naggar
This study investigate the effect of bee pollen (BP) and/or propolis (Pro) as an alternative to Mannan oligosaccharides (Bio-MOS, a hydrolyzed yeast with natural and artificial flavors Alltech Inc) when given continuously or intermittently on antioxidant enzymes, immunity, weight and morphology of lymphoid organs of broilers. Thus, 324 unsexed one-day-old Arbor Acres broilers were randomly distributed into nine treatment groups, each replicated 6 times of 6 birds per replicate. The chicks were kept in wire cages and fed the same basal diet and were submitted to the following treatments: control without supplementation (control) or supplemented with BP at 300 mg, Pro at 300 mg, BP+Pro at 300 mg each and Bio-MOS at 0...
October 10, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053872/resveratrol-alleviates-heat-stress-induced-impairment-of-intestinal-morphology-microflora-and-barrier-integrity-in-broilers
#13
C Zhang, X H Zhao, L Yang, X Y Chen, R S Jiang, S H Jin, Z Y Geng
This study was to investigate the effect of resveratrol on intestinal morphology, microfloras, and barrier integrity of broilers subjected to heat stress. Two-hundred-seventy 21-day-old Cobb male broilers were randomly allocated to 3 treatment groups, each of which included 6 replicates with 15 birds per replicate. The 3 treatment groups were as follows: the control group, in which birds were exposed to thermoneutral condition (22 ± 1°C), and the heat stress group and heat stress + resveratrol (400 mg/kg) group, in which birds were exposed to cyclic heat stress (33 ± 1°C for 10 h/d from 0800 to 1800 h and 22 ± 1°C for the remaining time...
October 10, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053870/effects-of-hydroxychloride-and-sulfate-form-of-zinc-and-manganese-supplementation-on-superoxide-dismutase-activity-and-immune-responses-post-lipopolysaccharide-challenge-in-poultry-fed-marginally-lower-doses-of-zinc-and-manganese
#14
V Perez, R Shanmugasundaram, M Sifri, T M Parr, R K Selvaraj
Effects of hydroxychloride (OHCl) and sulfate form of zinc and manganese supplementation on immune responses of birds fed marginally lower levels of zinc and manganese during an experimental lipopolysaccharide (LPS) injection were studied. In experiment I, 30-week-old layer birds were fed 50 mg/kg Zn+45 mg/kg Mn or 100 mg/kg Zn+90 mg/kg Mn in sulfate or OHCl form and injected with 0 or 500 μg/kg LPS in a 2 (50 mg Zn+45 mg Mn and 100 mg Zn+90 mg Mn) X 2 (sulfate and OHCl) X 2 (0 and 500 μg LPS) factorial setup of treatments for 10 weeks...
September 14, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053869/enzymatic-hydrolysis-of-fumonisins-in-the-gastrointestinal-tract-of-broiler-chickens
#15
B Grenier, H E Schwartz-Zimmermann, C Gruber-Dorninger, I Dohnal, M Aleschko, G Schatzmayr, W D Moll, T J Applegate
Fumonisins (FB) are among the most frequently detected mycotoxins in feedstuffs and finished feed, and recent data suggest that the functions of the gastrointestinal tract (GIT) in poultry species might be compromised at doses ranging from 10 to 20 mg/kg, close to field incidences and below the US and EU guidelines. Strategies are therefore necessary to reduce the exposure of poultry to FB. In the present study, we assessed the efficacy of fumonisin esterase FumD (EC 3.1.1.87, commercial name FUMzyme®) to cleave the tricarballylic acid side chains of FB, leading to the formation of non-toxic hydrolyzed fumonisins in the GIT of broiler chickens...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053863/a-case-of-a-newborn-with-blocked-rhd-antigen-and-hdfn
#16
Haijuan Wang, Jian Chen, Yongmei Jiang
A group O RhD-negative pregnant patient with anti-D antibody at titer 1:2048 delivered a baby boy by cesarean section at 38 + 6 weeks gestational age. The neonate typed as group O, but D antigen was at first uncertain. DAT and antibody screen of newborn were both positive. Various assays were used for D antigen determination. Ultimately, D antigen blocked by high-titer maternal anti-D antibody was confirmed. Total bilirubin of the newborn was 52.7 umol/L, and hemoglobin was 1.46 mg/dL. O RhD-negative red cells were used for an exchange transfusion...
October 19, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29053856/propolis-supplementation-attenuates-the-negative-effects-of-oxidative-stress-induced-by-paraquat-injection-on-productive-performance-and-immune-function-in-turkey-poults
#17
Ahmed O Abass, Nancy N Kamel, Walaa H Khalifa, G F Gouda, M A F El-Manylawi, Gamal M K Mehaisen, Magdi M Mashaly
Paraquat (PQ) is used as a herbicide in agriculture and causes oxidative and inflammatory damage to animal tissues. The current study was conducted to investigate the positive effects of dietary propolis (PR), as a potent naturally produced antioxidant, on growth performance and immune function of turkey poults exposed to oxidative stress induced by PQ injection. Native male turkey poults (n = 120, 49-d-old) were randomly assigned into 4 groups: poults received a basal diet with a daily subcutaneous PQ injection of 5 mg/kg BW for 7 consecutive days (PQ group), an experimental diet containing 1 g/kg PR with a daily subcutaneous PQ injection for 7 days (PR+PQ group), or received the experimental PR diet with a daily subcutaneous injection of 0...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053811/effects-of-the-supplemental-chromium-form-on-performance-and-oxidative-stress-in-broilers-exposed-to-heat-stress
#18
N Sahin, A Hayirli, C Orhan, M Tuzcu, F Akdemir, J R Komorowski, K Sahin
This experiment was conducted to investigate effects of the organic complex form of supplemental chromium (Cr) on performance, oxidative stress markers, and serum profile in broilers exposed to heat stress (HS). A total of 1,200 10-day-old boilers (Ross-308) was divided into one of the 6 treatments (2 environmental temperatures x 3 diets with different Cr forms). The birds were kept in temperature-controlled rooms at either 22 ± 2°C 24 h/d (thermoneutral, TN group) or 34 ± 2°C for 8 h/d, 08:00 to 17:00 h, followed by 22°C for 16 h (HS group) and fed either a basal diet (C) or the basal diet supplemented with Cr (200 μg/kg) through 1...
September 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053808/the-impact-of-supplemental-antioxidants-on-visual-function-in-nonadvanced-age-related-macular-degeneration-a-head-to-head-randomized-clinical-trial
#19
Kwadwo Owusu Akuffo, Stephen Beatty, Tunde Peto, Jim Stack, Jim Stringham, David Kelly, Irene Leung, Laura Corcoran, John M Nolan
Purpose: The purpose of this study was to evaluate the impact of supplemental macular carotenoids (including versus not including meso-zeaxanthin) in combination with coantioxidants on visual function in patients with nonadvanced age-related macular degeneration. Methods: In this study, 121 participants were randomly assigned to group 1 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc and an addition of 10 mg meso-zeaxanthin; n = 60) or group 2 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc; n = 61)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29053802/docosahexaenoic-acid-supplementation-in-pregnancy-modulates-placental-cellular-signaling-and-nutrient-transport-capacity-in-obese-women
#20
Susanne Lager, Vanessa I Ramirez, Ometeotl Acosta, Christiane Meireles, Evelyn Miller, Francesca Gaccioli, Fredrick J Rosario, Jonathan A L Gelfond, Kevin Hakala, Susan T Weintraub, Debra A Krummel, Theresa L Powell
Context: Maternal obesity in pregnancy has profound impacts on maternal metabolism and promotes placental nutrient transport, which may contribute to fetal overgrowth in these pregnancies. The fatty acid docosahexaenoic acid (DHA) has bioactive properties that may improve outcomes in obese pregnant women by modulating placental function. Objective: To determine the effects of DHA supplementation in obese pregnant women on maternal metabolism and placental function...
October 18, 2017: Journal of Clinical Endocrinology and Metabolism
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