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https://www.readbyqxmd.com/read/29454302/aerobic-exercise-inhibits-obesity-induced-respiratory-phenotype
#1
Jefferson Comin Jonco Aquino-Junior, BreAnne MacKenzie, Ana Roberta Almeida-Oliveira, Ana Carolina Martins, Manoel Carneiro Oliveira-Junior, Auriléa Aparecida Britto, Fernanda Magalhaes Arantes-Costa, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Ana Paula Ligeiro de Oliveira, Dioze Guadagnini, Luiz Osorio Leiria, Djalma Rabelo Ricardo, Mario Jose Abdalla Saad, Rodolfo Paula Vieira
PURPOSE: Obesity results in decreased lung function and increased inflammation. Moderate aerobic exercise (AE) reduced lung inflammation and remodeling in a variety of respiratory disease models. Therefore, this study investigated whether AE can attenuate a diet-induced obesity respiratory phenotype; including airway hyper-responsiveness (AHR), remodeling and inflammation. METHODS: Sixty C57Bl/6 male mice were distributed into four groups: control lean (CL), exercise lean (EL), obese (O) and obese exercise (OE) groups (2 sets of 7 and 8 mice per group; n = 15)...
February 14, 2018: Cytokine
https://www.readbyqxmd.com/read/29454288/apocynum-venetum-leaf-extract-reverses-depressive-like-behaviors-in-chronically-stressed-rats-by-inhibiting-oxidative-stress-and-apoptosis
#2
Xiangting Li, Ting Wu, Zhonghai Yu, Tingting Li, Jingsi Zhang, Zhennian Zhang, Min Cai, Wen Zhang, Jun Xiang, Dingfang Cai
BACKGROUND: Major depressive disorder (MDD) is a common but serious psychiatric disorder, but current treatments are inadequate for approximately half of the patients with MDD. Thus, better methods of treatment are urgently needed. This study aimed to investigate the antidepressant-like effects and potential mechanism of Apocynum venetum leaf extract (AVLE) in chronic unpredictable mild stress (CUMS) rat model of depression. MATERIALS AND METHODS: The CUMS rat model of depression was used to investigate the antidepressant-like activity and relevant mechanism of AVLE (30, 60, and 125 mg/kg, i...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29454278/towards-a-better-understanding-on-mercury-adsorption-by-magnetic-bio-adsorbents-with-%C3%AE-fe-2-o-3-from-pinewood-sawdust-derived-hydrochar-influence-of-atmosphere-in-heat-treatment
#3
Huabin Wang, Yong Liu, Jerosha Ifthikar, Lerong Shi, Aimal Khan, Zhulei Chen, Zhuqi Chen
Pyrolysis under protective atmosphere was regarded as an indispensable process for the preparation of biomass-based adsorbents to achieve higher surface areas. In this paper, magnetic carbon composites (MCC) that fabricated under air atmosphere showed an adsorption capacity of 167.22 mg/g in 200 ppm Hg(II), which was significantly higher than magnetic biochar (MBC, 31.80 mg/g) that fabricated under traditional nitrogen protection, and this remarkable performance of MCC was consistent in a wide range of pHs...
February 6, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29454277/nitrogen-removal-enhancement-using-lactic-acid-fermentation-products-from-food-waste-as-external-carbon-sources-performance-and-microbial-communities
#4
Jialing Tang, Xiaochang C Wang, Yisong Hu, Yunhui Pu, Jin Huang, Huu Hao Ngo, Yonggang Zeng, Yuyou Li
In this study, nitrogen removal using the lactic acid fermentation products from food waste and other external chemical carbon sources (sodium acetate, sodium lactate and starch) was investigated. Similar to sodium acetate and lactate, the lactic acid-enriched fermentation liquid from food waste (FLFW) exhibited a high denitrification rate (5.5 mg NO x -N/(g-VSS h)) and potential (0.16 g NO 3 - -N/g COD), and could achieve high NH 4 + -N and total nitrogen (TN) removal efficiencies during long-term operation...
February 8, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29454270/cadmium-induced-stress-response-of-phanerochaete-chrysosporium-during-the-biodegradation-of-2-2-4-4-tetrabromodiphenyl-ether-bde-47
#5
Mi Feng, Hua Yin, Yajuan Cao, Hui Peng, Guining Lu, Zehua Liu, Zhi Dang
Cd-induced stress response of Phanerochaete chrysosporium during the biodegradation of BDE-47 was investigated in this study, with the goal of elucidating the tolerance behavior and the detoxification mechanisms of P. chrysosporium to resist the Cd stress in the course of BDE-47 biodegradation, which has implications for expanding the application of P. chrysosporium in the bioremediation of Cd and BDE-47 combined pollution. The results suggested that single BDE-47 exposure did not induce obvious oxidative stress in P...
February 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454269/biological-effects-of-four-iron-containing-nanoremediation-materials-on-the-green-alga-chlamydomonas-sp
#6
Nhung H A Nguyen, Nadia R Von Moos, Vera I Slaveykova, Katrin Mackenzie, Rainer U Meckenstock, Silke Thűmmler, Julian Bosch, Alena Ševců
As nanoremediation strategies for in-situ groundwater treatment extend beyond nanoiron-based applications to adsorption and oxidation, ecotoxicological evaluations of newly developed materials are required. The biological effects of four new materials with different iron (Fe) speciations ([i] FerMEG12 - pristine flake-like milled Fe(0) nanoparticles (nZVI), [ii] Carbo-Iron ® - Fe(0)-nanoclusters containing activated carbon (AC) composite, [iii] Trap-Ox® Fe-BEA35 (Fe-zeolite) - Fe-doped zeolite, and [iv] Nano-Goethite - 'pure' FeOOH) were studied using the unicellular green alga Chlamydomonas sp...
February 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454264/development-and-validation-of-uplc-ms-ms-assay-for-quantification-of-cladrin-absolute-bioavailability-and-dose-proportionality-study-in-rats
#7
Mamunur Rashid, Sandeep K Singh, Mohd Yaseen Malik, Sadaf Jahan, Swati Chaturvedi, Isha Taneja, Kanumuri Sivarama Raju, Zaiba Naseem, J R Gayen, Muhammad Wahajuddin
Cladrin, an isoflavone is a major bioactive constituent found in stem bark of Butea monosperma with remarkable osteogenic activity. A speedy and sensitive UPLC coupled tandem mass spectrometry (UPLC-MS/MS) method was developed, validated and successfully applied to bioavailability, blood partitioning, plasma protein binding, intravenous and multiple-dose oral pharmacokinetics of cladrin in rats. Separation was done on C18 column (5.0 μm, 4.6 × 50 mm) using mobile phase containing acetonitrile and 0.10% formic acid in the ratio of 65:35 (v/v) with 0...
January 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29454260/solar-photo-fenton-treatment-of-microcystin-lr-in-aqueous-environment-transformation-products-and-toxicity-in-different-water-matrices
#8
Akin Karci, Elizabeth M Wurtzler, Armah A de la Cruz, David Wendell, Dionysios D Dionysiou
Transformation products and toxicity patterns of microcystin-LR (MC-LR), a common cyanotoxin in freshwaters, during degradation by solar photo-Fenton process were studied in the absence and presence of two major water components, namely fulvic acid and alkalinity. The transformation products m/z 795, 835, 515/1030 and 532 can be formed through attack of OH on the conjugated carbon double bonds of Adda. Transformation products with m/z 1010, 966 and 513 can be generated through the attack of OH on the methoxy group of Adda...
January 2, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29454221/-13-c-phenylalanine-breath-test-and-serum-biopterin-in-schizophrenia-bipolar-disorder-and-major-depressive-disorder
#9
Toshiya Teraishi, Masahiro Kajiwara, Hiroaki Hori, Daimei Sasayama, Shinsuke Hidese, Junko Matsuo, Ikki Ishida, Yasuhiro Kajiwara, Yuji Ozeki, Miho Ota, Kotaro Hattori, Teruhiko Higuchi, Hiroshi Kunugi
Phenylalanine is required for the synthesis of the neurotransmitters dopamine, noradrenaline, and adrenaline. The rate-limiting step for phenylalanine metabolism is catalyzed by phenylalanine hydroxylase (PAH) and its cofactor tetrahydrobiopterin. We aimed to detect altered phenylalanine metabolism in major psychiatric disorders using the l-[1- 13 C]phenylalanine breath test ( 13 C-PBT) and serum biopterin levels. We also investigated association of PAH mutations with schizophrenia and phenylalanine metabolism...
February 3, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29454173/photo-assisted-electrochemical-abatement-of-trifluralin-using-a-cathode-containing-a-c-60-carbon-nanotubes-composite
#10
Aliyeh Hasanzadeh, Alireza Khataee, Mahmoud Zarei, Sang Woo Joo
This work reports the potential application of modified gas-diffusion electrode (GDE) with C 60 -CNT composite, as a stable and efficient cathode material for degradation of trifluralin (TRL) pesticide by photo-assisted electrochemical (PE) process. C 60 -CNT composite was prepared and characterized. Subsequently, a novel C 60 -CNT composite modified GDE cathode was developed and the electrochemical and physical characteristics of the modified GDEs were studied. C 60 -CNT composite/GDE showed great efficiencies for electro-generating H 2 O 2 , owing to huge surface area and high conductivity...
February 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29454172/toxicity-of-lanthanum-oxide-nanoparticles-to-the-fungus-moniliella-wahieum-y12-t-isolated-from-biodiesel
#11
Lin Zhang, Lingyan Zhou, Qing X Li, Hong Liang, Huaming Qin, Stephen Masutani, Brandon Yoza
Moniliella wahieum Y12 T , isolated from biodiesel was used as a model organism to assess the use of lanthanum oxide (La 2 O 3 ) (60-80 nm) and silver oxide (AgO) (10-40 nm) nanoparticles as potential fungal inhibitors. This is the first study to investigate the use of nanoscale La 2 O 3 as a eukaryotic bio-inhibitor. The AgO nanoparticles were relatively effective at inhibiting the growth of M. wahieum Y12 T . The half maximal effective concentration (EC 50 ) for AgO was 0.012 mg/mL as compared with 4.63 mg/mL of La 2 O 3 ...
February 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29454171/reactive-oxygen-and-iron-species-monitoring-to-investigate-the-electro-fenton-performances-impact-of-the-electrochemical-process-on-the-biodegradability-of-metronidazole-and-its-by-products
#12
Arwa Aboudalle, Florence Fourcade, Aymen Amin Assadi, Lionel Domergue, Hayet Djelal, Thomas Lendormi, Samir Taha, Abdeltif Amrane
In this study, the monitoring of reactive oxygen species and the regeneration of the ferrous ions catalyst were performed during electro-Fenton (EF) process to highlight the influence of operating parameters. The removal of metronidazole (MTZ) was implemented in an electrochemical mono-compartment batch reactor under various ranges of current densities, initial MTZ and ferrous ions concentrations, and pH values. It was found that under 0.07 mA cm -2 , 0.1 mM of ferrous ions and pH = 3, the efficiency of 100 mg L -1 MTZ degradation and mineralization were 100% within 20 min and 40% within 135 min of electrolysis, respectively...
February 13, 2018: Chemosphere
https://www.readbyqxmd.com/read/29454160/vascular-parameters-continue-to-decrease-post-exposure-with-simultaneous-but-not-individual-exposure-to-bpa-and-hypoxia-in-zebrafish-larvae
#13
Alysha D Cypher, Bryce Fetterman, Brian Bagatto
How fish respond to hypoxia, a common stressor, can be altered by simultaneous exposure to pollutants like bisphenol A (BPA), a plasticizer. BPA is cardiotoxic and interferes with the hypoxia inducible factor pathway (HIF-1α), therefore disrupting the hypoxic response. Co-exposure to hypoxia and BPA also causes severe bradycardia and reduced cardiac output in zebrafish larvae. The purpose of this work was to determine how the cardiovascular effects of co-exposure vary with BPA concentration and persist beyond exposure...
February 14, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29454035/high-and-low-doses-of-cocaine-intake-are-differentially-regulated-by-dopamine-d2-receptors-in-the-ventral-tegmental-area-and-the-nucleus-accumbens
#14
R Chen, S McIntosh, S E Hemby, H Sun, T Sexton, Thomas Martin, S R Childers
Dopamine D2 receptors (D2Rs) in the ventral tegmental area (VTA) and the nucleus accumbens (NAc) are associated with vulnerability to addiction; however, whether D2Rs in these two brain regions play differential roles in regulation of drug intake is unknown. Here, we compared the effect of decreased mRNA level of Drd2 in each region on cocaine self-administration in a dose-response function. Drd2 mRNA levels in rat VTA or NAc were knocked down by bilateral microinjection of lentivirus coding shRNAs against rat Drd2...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29453997/effects-of-para-methoxyamphetamine-pma-on-agonistic-encounters-between-male-mice
#15
Mercedes Martín-López, Ana T Muela, María Cavas, José Francisco Navarro
Para-methoxyamphetamine (PMA) is a synthetic drug chemically similar to the recreational drug 3,4-methylenedioxy-methamphetamine (MDMA or "ecstasy") and often replaces MDMA in tablets that show an "ecstasy" logo. PMA displays a higher toxic potential than MDMA, but the behavioral profile of PMA has been scarcely studied in animal models. Here we evaluated the effects of PMA (2, 4, 8, and 12 mg/kg, i.p.) on agonist encounters between male mice using an ethopharmacological approach, the isolation-induced aggression model...
February 14, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29453978/venlafaxine-prevents-morphine-antinociceptive-tolerance-the-role-of-neuroinflammation-and-the-l-arginine-nitric-oxide-pathway
#16
Mohammad Taghi Mansouri, Bahareh Naghizadeh, Behnam Ghorbanzadeh, Soheila Alboghobeish, Neda Amirgholami, Gholamreza Houshmand, Omar Cauli
Opioid-induced neuroinflammation and the nitric oxide (NO) signal-transduction pathway are involved in the development of opioid analgesic tolerance. The antidepressant venlafaxine (VLF) modulates NO in nervous tissues, and so we investigated its effect on induced tolerance to morphine, neuroinflammation, and oxidative stress in mice. Tolerance to the analgesic effects of morphine were induced by injecting mice with morphine (50 mg/kg) once a day for three consecutive days; the effect of co-administration of VLF (5 or 40 mg/kg) with morphine was similarly tested in a separate group...
February 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29453945/evaluation-of-lipid-peroxidation-and-antioxidant-defense-mechanisms-in-the-bone-of-rats-in-conditions-of-separate-and-combined-administration-of-vanadium-v-and-magnesium-mg
#17
Agnieszka Ścibior, Dorota Gołębiowska, Agnieszka Adamczyk, Joanna Kurus, Magdalena Staniszewska, Ilona Sadok
The impact of vanadium (V) and magnesium (Mg) applied as sodium metavanadate (SMV, 0.125 mg V/ml) and magnesium sulfate (MS, 0.06 mg Mg/ml) on oxidative stress markers in bone of male Wistar rats was investigated. Some of them were also measured in the liver, e.g. l-ascorbic acid (hepatic L-AA). Additionally, relationships between selected indices determined in bone were examined. SMV alone (Group II) did not significantly alter the level of TBARS and the activity of SOD, compared with the control (Group I), but it slightly reduced the GR activity (by 13%) and the L-AA level (by 15...
February 14, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29453923/magnesium-upregulates-insulin-receptor-and-glucose-transporter-4-in-streptozotocin-nicotinamide-induced-type-2-diabetic-rats
#18
Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel, Daniel Abiodun Adekunbi
OBJECTIVE: We investigated the effects of magnesium supplementation on glucose tolerance, insulin sensitivity, oxidative stress as well as the concentration of insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide induced type-2 diabetic (T2D) rats. METHODS: Rats were divided into four groups designated as: 1) control (CTR); 2) diabetic untreated (DU); 3) diabetic treated with 1 mg of Mg/kg diet (Mg1-D); and 4) diabetic treated with 2 mg of Mg/kg diet (Mg2-D)...
January 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29453917/comparative-chemical-investigation-and-evaluation-of-antioxidant-and-tyrosinase-inhibitory-effects-of-withania-somnifera-l-dunal-and-solanum-nigrum-l-berries
#19
Abdul Hameed, Naveed Akhtar
In the present study, berries of two different species of Solanaceae family, Withania somnifera (WS) and Solanum nigrum (SN), were extracted in methanol and then fractionated with solvents, ranging from non-polar to polar, for their phytochemical profiling and investigation of antioxidant and tyrosinase enzyme inhibition capacity. The methanolic extract and n-hexane, ethyl acetate (WSEA, SNEA) and aqueous fractions were chemically analyzed and evaluated for biological activity. Total flavonoids and total phenolics were quantified in WSEA (96...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453787/a-phase-ii-trial-of-riluzole-an-antagonist-of-metabotropic-glutamate-receptor-1-grm1-signaling-in-patients-with-advanced-melanoma
#20
Janice M Mehnert, Ann W Silk, Yu Wen, J H Lee, Liesel Dudek, Byeong-Seon Jeong, Jiadong Li, Jason M Schenkel, Evita Sadimin, Michael Kane, Hongxia Lin, Weichung J Shih, Andrew Zloza, Suzie Chen, James S Goydos
Studies demonstrate that GRM, expressed by >60% of human melanomas, may be a therapeutic target. We performed a phase II trial of 100 mg po bid of riluzole, an inhibitor of GRM1 signaling, in patients with advanced melanoma with the primary endpoint of response rate. Thirteen patients with GRM1-positive tumors were enrolled. No objective responses were observed and accrual was stopped. Stable disease was noted in 6 (46%) patients, with 1 patient on study for 42 weeks. Riluzole was well-tolerated, with fatigue (62%) as the most common adverse event...
February 17, 2018: Pigment Cell & Melanoma Research
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