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https://www.readbyqxmd.com/read/27884114/hyperemesis-gravidarum-and-placental-dysfunction-disorders
#1
Heleen M Koudijs, Ary I Savitri, Joyce L Browne, Dwirani Amelia, Mohammad Baharuddin, Diederick E Grobbee, Cuno S P M Uiterwaal
BACKGROUND: Evidence about the consequence of hyperemesis gravidarum (HG) on pregnancy outcomes is still inconclusive. In this study, we evaluated if occurrence of hyperemesis gravidarum is associated with placental dysfunction disorders and neonatal outcomes. METHODS: A prospective cohort study was conducted in a maternal and child health primary care referral center, Budi Kemuliaan Hospital and its branch, in Jakarta, Indonesia. 2252 pregnant women visiting the hospital for regular antenatal care visits from July 2012 until October 2014 were included at their first clinic visit...
November 25, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27880038/excessive-vomiting-in-pregnancy-active-component-service-women-u-s-armed-forces-2005-2014
#2
Valerie F Williams, Leslie L Clark, Gi-Taik Oh
Up to 80% of women experience some form of nausea and vomiting during pregnancy. However, in some women, nausea and vomiting can be excessive and require inpatient and/or outpatient treatment. Data were obtained on 149,071 live births from 116,510 service women from 1 January 2005 through 31 December 2014. A total of 19,175 of the service women with live births had pregnancies complicated by excessive vomiting in pregnancy (EVP) and accounted for 20,511 EVP cases (overall rate of 13.8%). Mild and severe hyperemesis gravidarum (HG) combined accounted for almost two-thirds of the total EVP cases...
November 2016: MSMR
https://www.readbyqxmd.com/read/27845881/morning-sickness-of-pregnancy-more-than-meets-the-eye
#3
Noorazizah Arsad, Kah Teik Chew, Nur Azurah Abdul Ghani, Hui Jan Tan, Norasyikin A Wahab, Nor Azlin Mohd Ismail
Wernicke's encephalopathy (WE) is a rare life-threatening complication following severe hyperemesis gravidarum. Early recognition of this condition and prompt thiamine administration is the key to preventing devastating sequelae. We report a successful delivery of a small-for-gestational-age (SGA) baby by a patient with WE and thyrotoxicosis in pregnancy.
November 15, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27821979/comparison-of-efficacy-of-granisetron-and-promethazine-in-control-of-hyperemesis-gravidarum
#4
Ashraf Aleyasin, Elham Saffarieh, Hassan Torkamandi, Somayeh Hanafi, Fariborz Sadeghi, Atossa Mahdavi, Fatemeh Bahmaei, Mohammadreza Javadi
PURPOSE: Hyperemesis gravidarum is the third leading cause of hospitalization during pregnancy. 5-HT3-receptor antagonists are the most effective against chemotherapy-induced nausea and vomiting and radiation. This randomized study aimed to compare and evaluate the efficacies of granisetron and promethazine for controlling nausea and vomiting of pregnancy. METHODS: The included patients were administered (oral and intravenous) granisetron and promethazine randomly...
December 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27798048/the-prevalence-of-unplanned-pregnancy-ending-in-birth-associated-factors-and-health-outcomes
#5
J Goossens, Y Van Den Branden, L Van der Sluys, I Delbaere, A Van Hecke, S Verhaeghe, D Beeckman
STUDY QUESTION: What are associated factors of unplanned pregnancies ending in birth? SUMMARY ANSWER: Pregnancies that were less planned were associated with women of lower socio-economic status (SES), an unhealthier lifestyle before and during the pregnancy, more stress, and less social support. WHAT IS KNOWN ALREADY: In Europe, the prevalence of unplanned pregnancy leading to birth varies. Unplanned pregnancy is more common among socially disadvantaged women, and associated with adverse pregnancy outcomes...
October 24, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27792038/role-of-cannabis-in-digestive-disorders
#6
Hemant Goyal, Umesh Singla, Urvashi Gupta, Elizabeth May
Cannabis sativa, a subspecies of the Cannabis plant, contains aromatic hydrocarbon compounds called cannabinoids. [INCREMENT]-Tetrahydrocannabinol is the most abundant cannabinoid and is the main psychotropic constituent. Cannabinoids activate two types of G-protein-coupled cannabinoid receptors: cannabinoid type 1 receptor and cannabinoid type 2 receptor. There has been ongoing interest and development in research to explore the therapeutic potential of cannabis. [INCREMENT]-Tetrahydrocannabinol exerts biological functions on the gastrointestinal (GI) tract...
October 27, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27777478/clinical-and-radiological-correlations-in-patients-with-gestational-trophoblastic-disease
#7
Lana de Lourdes Aguiar Lima, Raphael Câmara Medeiros Parente, Izildinha Maestá, Joffre Amim Junior, Jorge Fonte de Rezende Filho, Carlos Antonio Barbosa Montenegro, Antônio Braga
Gestational trophoblastic disease is an abnormality of pregnancy that encompasses a group of diseases that differ from each other in their propensity for regression, invasion, metastasis, and recurrence. In the past, it was common for patients with molar pregnancy to present with marked symptoms: copious bleeding; theca lutein cysts; uterus larger than appropriate for gestational age; early preeclampsia; hyperemesis gravidarum; and hyperthyroidism. Currently, with early diagnosis made by ultrasound, most patients are diagnosed while the disease is still in the asymptomatic phase...
July 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27766407/the-effects-of-gestational-transient-thyrotoxicosis-on-the-perinatal-outcomes-a-case-control-study
#8
Satoko Kinomoto-Kondo, Nagayoshi Umehara, Shiori Sato, Kohei Ogawa, Takeo Fujiwara, Naoko Arata, Haruhiko Sago
PURPOSE: To study the effects of gestational transient thyrotoxicosis (GTT) on pregnancy outcomes. METHODS: This case-control study retrospectively analyzed 7976 women with singleton pregnancies whose thyroid function was measured before 16 weeks of gestation and who delivered at ≥22 weeks of pregnancy. GTT was defined as hyperthyroidism (free thyroxine [FT4] level: ≥95th percentile) in the early pregnancy, which normalized in mid-pregnancy without thyroid-stimulating hormone receptor antibodies...
October 20, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27766142/hyperemesis-gravidarum-is-associated-with-substantial-economic-burden-in-addition-to-severe-physical-and-psychological-suffering
#9
Jone Trovik, Åse Vikanes
Hyperemesis gravidarum (HG) affects 1 % of all pregnant women and in western societies it is the most common cause for hospital admission during first trimester. The economic burden of the disease has barely been studied. To estimate the Israeli national burden of HG, Konikoff and co-workers obtained data retrospectively on hospital costs as well as loss of workdays from 184 women hospitalized due to HG from December 2010 until December 2013. Their findings emphasise the need for better treatment to reduce the burden of this disease both for the individual as well as the society...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27763485/wernicke-s-encephalopathy-due-to-hyperemesis-gravidarum-clinical-and-magnetic-resonance-imaging-characteristics
#10
V V Ashraf, J Prijesh, R Praveenkumar, K Saifudheen
Hyperemesis gravidarum-induced Wernicke's encephalopathy (WE) is an underestimated condition. The purpose of this study is to improve its awareness and early diagnosis. We report five cases of WE secondary to hyperemesis gravidarum. Classic triad of encephalopathy, ataxia, and ocular signs was seen in four out of five patients. Two unusual features noted in this series were papilledema in one patient and severe sensory-motor peripheral neuropathy in one patient. Magnetic resonance imaging (MRI) was abnormal in all the five patients, and high signal in medial thalamus and surrounding the aqueduct was the most common abnormality (5/5)...
October 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27757817/novel-treatments-for-cyclic-vomiting-syndrome-beyond-ondansetron-and-amitriptyline
#11
Sanjay Bhandari, Thangam Venkatesan
Cyclic vomiting syndrome (CVS) is a chronic functional gastrointestinal disorder that is characterized by episodic nausea and vomiting. Initially thought to only affect children, CVS in adults was often misdiagnosed with significant delays in therapy. Over the last decade, there has been a considerable increase in recognition of CVS in adults but there continues to be a lack of knowledge about management of this disorder. This paper seeks to provide best practices in the treatment of CVS and also highlight some novel therapies that have the potential in better treating this disorder in the future...
October 18, 2016: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/27741549/management-of-hyperthyroidism-during-the-preconception-phase-pregnancy-and-the-postpartum-period
#12
Sudipa Sarkar, Lindsay A Bischoff
Hyperthyroidism can occur during pregnancy and the postpartum period, and the treatment of hyperthyroidism should be considered in the preconception phase. Pregnancy has multiple normal physiologic effects on thyroid hormone, which is a separate process distinct from syndromes such as transient hyperthyroidism of hyperemesis gravidarum. The rationale regarding antithyroid drug use during different stages of pregnancy is reviewed, including the literature regarding adverse neonatal outcomes such as aplasia cutis and methimazole embryopathy in the setting of first trimester maternal methimazole use...
November 2016: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/27733901/hyperemesis-gravidarum-in-northern-israel-a-retrospective-epidemiological-study
#13
Tom Konikoff, Tehila Avraham, Ella Ophir, Jacob Bornstein
BACKGROUND: Hyperemesis gravidarum (HG) is characterized by severe intractable nausea and vomiting in pregnancy leading to electrolyte imbalance, ketonuria, and weight loss. The cause is unknown. This study sought to investigate the prevalence and characteristics of HG in the Western Galilee in two ethnic populations and to estimate its economic burden. METHODS: Data on ethnicity, age, gestational age, number of pregnancies, and length of hospitalization were collected from the medical files of all women with HG admitted to the Galilee Medical Center in 2010-2013...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27731292/treatments-for-hyperemesis-gravidarum-and-nausea-and-vomiting-in-pregnancy-a-systematic-review-and-economic-assessment
#14
Amy O'Donnell, Catherine McParlin, Stephen C Robson, Fiona Beyer, Eoin Moloney, Andrew Bryant, Jennifer Bradley, Colin Muirhead, Catherine Nelson-Piercy, Dorothy Newbury-Birch, Justine Norman, Emma Simpson, Brian Swallow, Laura Yates, Luke Vale
BACKGROUND: Nausea and vomiting in pregnancy (NVP) affects up to 85% of all women during pregnancy, but for the majority self-management suffices. For the remainder, symptoms are more severe and the most severe form of NVP - hyperemesis gravidarum (HG) - affects 0.3-1.0% of pregnant women. There is no widely accepted point at which NVP becomes HG. OBJECTIVES: This study aimed to determine the relative clinical effectiveness and cost-effectiveness of treatments for NVP and HG...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27701665/treatments-for-hyperemesis-gravidarum-and-nausea-and-vomiting-in-pregnancy-a-systematic-review
#15
Catherine McParlin, Amy O'Donnell, Stephen C Robson, Fiona Beyer, Eoin Moloney, Andrew Bryant, Jennifer Bradley, Colin R Muirhead, Catherine Nelson-Piercy, Dorothy Newbury-Birch, Justine Norman, Caroline Shaw, Emma Simpson, Brian Swallow, Laura Yates, Luke Vale
Importance: Nausea and vomiting affects approximately 85% of pregnant women. The most severe form, hyperemesis gravidarum, affects up to 3% of women and can have significant adverse physical and psychological sequelae. Objective: To summarize current evidence on effective treatments for nausea and vomiting in pregnancy and hyperemesis gravidarum. Evidence Review: Databases were searched to June 8, 2016. Relevant websites and bibliographies were also searched...
October 4, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27692442/hypophosphatemia-in-users-of-cannabis
#16
Peter E Cadman
As cannabis use has legalized for medical and recreational use in several states, the medical community has become more aware of the drug's potential toxicities. First described in 2004, cannabinoid hyperemesis syndrome is increasingly recognized as a cause of hospitalization among drug users. However, little information is available in the medical literature regarding electrolyte abnormalities in this syndrome. Between 2011 and 2014, six men were treated for cannabinoid hyperemesis syndrome at the Veterans Affairs Medical Center in San Diego, CA, and found to have significant hypophosphatemia (phosphate range, <1-1...
September 27, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27663074/genetic-analysis-of-hyperemesis-gravidarum-reveals-association-with-intracellular-calcium-release-channel-ryr2
#17
Marlena Schoenberg Fejzo, Ronny Myhre, Lucía Colodro-Conde, Kimber W MacGibbon, Janet S Sinsheimer, M V Prasad Linga Reddy, Päivi Pajukanta, Dale R Nyholt, Margaret J Wright, Nicholas G Martin, Stephanie M Engel, Sarah E Medland, Per Magnus, Patrick M Mullin
Hyperemesis Gravidarum (HG), severe nausea/vomiting in pregnancy (NVP), can cause poor maternal/fetal outcomes. Genetic predisposition suggests the genetic component is essential in discovering an etiology. We performed whole-exome sequencing of 5 families followed by analysis of variants in 584 cases/431 controls. Variants in RYR2 segregated with disease in 2 families. The novel variant L3277R was not found in any case/control. The rare variant, G1886S was more common in cases (p = 0.046) and extreme cases (p = 0...
September 20, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27625723/treatment-of-nausea-and-vomiting-in-pregnancy-factors-associated-with-ed-revisits
#18
Brian R Sharp, Kristen M Sharp, Brian Patterson, Suzanne Dooley-Hash
INTRODUCTION: Nausea and vomiting in pregnancy (NVP) is a condition that commonly affects women in the first trimester of pregnancy. Despite frequently leading to emergency department (ED) visits, little evidence exists to characterize the nature of ED visits or to guide its treatment in the ED. Our objectives were to evaluate the treatment of NVP in the ED and to identify factors that predict return visits to the ED for NVP. METHODS: We conducted a retrospective database analysis using the electronic medical record from a single, large academic hospital...
September 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27625583/clinical-presentation-and-treatment-outcome-of-molar-pregnancy-ten-years-experience-at-a-tertiary-care-hospital-in-dammam-saudi-arabia
#19
Ayman A Al-Talib
OBJECTIVES: To study the clinical presentation and treatment outcome of molar pregnancy at a Tertiary Care Hospital in Dammam, Saudi Arabia. MATERIALS AND METHODS: Reviewed medical records of all molar pregnancy cases among all the deliveries at a tertiary care hospital in Dammam from 2005 to 2014, after approval by institutional ethical review committee. Data abstracted included patient's age, parity, presenting symptoms, gestational age at diagnosis, uterine size, ultrasonographic findings, BhCG level at the time of diagnosis and at follow-up after evacuation, and blood loss during evacuation...
September 2016: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/27597918/successful-treatment-of-suspected-cannabinoid-hyperemesis-syndrome-using-haloperidol-in-the-outpatient-setting
#20
Jennifer L Jones, Karen E Abernathy
Chronic use of cannabis can result in a syndrome of hyperemesis characterized by cyclical vomiting without any other identifiable causes. Cannabinoid hyperemesis syndrome (CHS) is seldom responsive to traditional antiemetic therapies. Despite frequent nausea and vomiting, patients may be reluctant to discontinue use of cannabis. We report a case of severe, refractory CHS with complete resolution of nausea and vomiting after treatment with haloperidol in the outpatient setting. After review of the literature, we believe this is the first reported successful outpatient treatment of CHS and suggests a potential treatment for refractory patients...
2016: Case Reports in Psychiatry
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