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https://www.readbyqxmd.com/read/29768651/cannabinoid-hyperemesis-syndrome-reports-of-fatal-cases
#1
Mahra Nourbakhsh, Angela Miller, Jeff Gofton, Graham Jones, Bamidele Adeagbo
Cannabinoid hyperemesis syndrome (CHS) is one of the more clinically challenging effects of cannabis consumption. It is characterized by cyclic attacks of nausea and vomiting in chronic cannabinoid users and learned behavior of compulsive hot bathing. The deaths of a 27-year-old female, a 27-year-old male, and a 31-year-old male with a history of CHS are reported. The decedents had a history of cyclical nausea and vomiting, chronic cannabinoid use and negative laboratory, radiological and endoscopic findings...
May 16, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29754832/ondansetron-in-pregnancy-and-the-risk-of-congenital-malformations-a-systematic-review
#2
Melissa Lavecchia, Radha Chari, Sandra Campbell, Sue Ross
OBJECTIVE: Ondansetron, not approved for use in pregnancy, is increasingly being prescribed for nausea and vomiting in pregnancy and hyperemesis gravidarum. A number of recent lawsuits have highlighted the possibility that ondansetron may cause congenital malformations. The aim of this study was to systematically review epidemiological evidence on the potential association of prenatal exposure to ondansetron and congenital malformations. METHODS: Systematic searches in Medline and Embase were performed in June 2017 using controlled vocabulary and key words, and references of search results were reviewed...
May 10, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29754072/serum-betatrophin-angiopoietin-like-protein-8-angptl8-levels-in-pregnancies-affected-by-hyperemesis-gravidarum
#3
Burcu Timur, Serap Fırtına Tuncer, Serkan Bodur, Hakan Timur, Aytekin Tokmak, Funda Gucel, Metin Altay
OBJECTIVE: The association between serum betatrophin levels and hyperemesis gravidarum (HEG) remains unknown. The aim of this study was to determine and understand the alterations in serum betatrophin levels in pregnancies complicated by HEG compared with unaffected normal pregnancies. STUDY DESIGN: A cohort study was carried out to evaluate serum betatrophin levels in patients with HEG. Serum betatrophin concentrations were measured with other metabolic markers for lipids and glucose metabolism in 40 singleton pregnancies affected by HEG and 40 gestational age- and body mass index-matched controls...
April 24, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29745720/cannabinoid-hyperemesis-syndrome
#4
Eduardo Valdivielso Cortázar, Patricia Ucha Abal, Pedro Alonso Aguirre
We report the case of a 30-year-old female with a history of cannabis use from 16 years of age. The patient presented to the Gastroenterology Clinic due to cyclical epigastric pain associated with postprandial stomach heaviness, nausea and vomiting. She was admitted due to a worsening of her condition, which prevented her from leading a normal life.
May 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29745439/cannabinoids-and-gastrointestinal-motility-pharmacology-clinical-effects-and-potential-therapeutics-in-humans
#5
REVIEW
M Camilleri
BACKGROUND: Cannabinoid agents and cannabis are frequently used for relief of diverse gastrointestinal symptoms. PURPOSE: The objective of this article is to increase the awareness of gastroenterologists to the effects of cannabinoids on gastrointestinal motility, as gastroenterologists are likely to encounter patients who are taking cannabinoids, or those with dysmotility that may be associated with cannabinoid mechanisms. The non-selective cannabinoid agonist, dronabinol, retards gastric emptying and inhibits colonic tone and phasic pressure activity...
May 10, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29744060/what-can-go-wrong-in-hyperemesis-gravidarum-wernicke-korsakoff-syndrome-in-bulawayo-zimbabwe
#6
Fiona T Nhari, Narcisious B T Dzvanga
We report two cases of Wernicke-Korsakoff syndrome (WKS) secondary to hyperemesis gravidarum. Oral thiamine was administered (intravenous unavailable locally). However, both the patient's condition improved in the first 48 h and progressively over a month. Initially, WKS is missed due to rare feature of full classical triad of symptoms, especially in nonalcoholics.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29728080/vomiting-in-pregnancy-is-associated-with-a-higher-risk-of-low-birth-weight-a-cohort-study
#7
Clive J Petry, Ken K Ong, Kathryn Beardsall, Ieuan A Hughes, Carlo L Acerini, David B Dunger
BACKGROUND: Low birth weight has important short- and long-term health implications. Previously it has been shown that pregnancies affected by hyperemesis gravidarum in the mother are at higher risk of having low birth weight offspring. In this study we tested whether such risks are also evident with less severe nausea and vomiting in pregnancy. METHODS: One thousand two hundred thirty-eight women in the prospective Cambridge Baby Growth Study filled in pregnancy questionnaires which included questions relating to adverse effects of pregnancy and drugs taken during that time...
May 4, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29727913/variation-in-hyperemesis-gravidarum-definition-and-outcome-reporting-in-randomised-clinical-trials-a-systematic-review
#8
M H Koot, R C Boelig, J van 't Hooft, J Limpens, T J Roseboom, R C Painter, I J Grooten
BACKGROUND: Hyperemesis gravidarum (HG) is a common cause of hospital admission in early pregnancy. There is no international consensus on the definition of HG, or on outcomes that should be reported in trials. Consistency in definition and outcome reporting is important for the interpretation and synthesis of data in meta-analyses. OBJECTIVE: We aimed to identify which HG definitions and outcomes are currently in use in trials. SEARCH STRATEGY: We searched the following sources: (1) Cochrane Central Register of Controlled Trials, (2) Embase and (3) Medline for published trials and the WHO-ICTRP database for ongoing trials (27-Ocotber-2017) SELECTION CRITERIA: All randomised clinical trials reporting on any intervention for HG were eligible...
May 4, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29704814/developing-and-validating-a-prognostic-index-predicting-re-hospitalization-of-patients-with-hyperemesis-gravidarum
#9
Zohar H Morris, Abed N Azab, Shlomit Harlev, Ygal Plakht
OBJECTIVE: Hyperemesis Gravidarum (HG) can have adverse effects on pregnant women's quality of life and is the main cause for hospitalization in the first half of the pregnancy. Between 19%-30% of the women admitted to hospital return for a second hospitalization during their pregnancy. These hospitalizations create a burden on the health system and are associated with high health care costs. The aim of this study was to develop a prediction tool that predicts re-hospitalization of women with HG and to validate it...
April 22, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29687933/ventricular-tachycardia-in-a-primigravida-with-hyperemesis-gravidarum
#10
Puneet K Kochhar, Pranay Ghosh
Hyperemesis gravidarum is persistent vomiting, seen more often in the first trimester of pregnancy, when the patient is unable to maintain adequate hydration. Intractable vomiting can lead to severe electrolyte imbalance, which may cause electrocardiogram abnormalities. Occasionally, ventricular tachycardia can complicate a pregnancy. Although its occurrence usually indicates an underlying cardiac structural or arrhythmic abnormality, it may rarely occur in a pregnant patient with structurally normal heart...
April 24, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29668490/low-dose-mirtazapine-in-major-depression-developed-after-hyperemesis-gravidarum-a-case-series
#11
Faruk Uguz, Keziban Turgut, Adem Aydin, Mehmet Ak
No abstract text is available yet for this article.
April 9, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29630025/direct-percutaneous-endoscopic-jejunostomy-for-the-management-of-gastroparesis-in-pregnancy
#12
Sawan Vijay Rupani, William F Ergen, Frederick Weber, Shajan Peter
BACKGROUND: Providing meaningful nutrition in cases of refractory hyperemesis during pregnancy can be challenging; although intragastric enteral nutrition is the most common approach, it is contraindicated in certain cases and carries the risk of increased nausea and vomiting. CASE: A 36-year-old primigravid woman with a history of gastroparesis presented at 16 weeks of gestation with nausea and vomiting. With no improvement with conventional approaches and signs of malnutrition, a direct percutaneous endoscopic jejunostomy was placed...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29616923/evaluation-of-diet-quality-and-hyperemesis-gravidarum-in-pregnant-women-according-to-income
#13
Stamatia-Maria Kontonika, Maria G Grammatikopoulou, Xenophon Theodoridis, Efrosyni Tsirou, Konstantinos Gkiouras, Ilias Tirodimos, Monder Amari, Theodore Dardavessis, Dimitrios G Goulis, Michael Chourdakis
No abstract text is available yet for this article.
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29599677/venom-immunotherapy-and-pregnancy
#14
Krzysztof Pałgan, Magdalena Żbikowska-Götz, Elżbieta Chrzaniecka, Zbigniew Bartuzi
Introductions: The efficiency of venom immunotherapy (VIT) has been well documented by many studies. However, the most important for VIT is safety, particularly for a pregnant woman and a fetus. Aim: To establish the influence of continuation of VIT on pregnant women and offspring. Material and methods: The 6 women became pregnant during a specific immunotherapy. We retrospectively analyzed the influence of the immunotherapy on any complications for the pregnant women and their infants...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29596284/a-case-of-wernicke-encephalopathy-developing-after-ileal-bypass-surgery
#15
Tülay Kamaşak, Sibel Kul, Mustafa Tuşat, Nezir Ozgun, Ali Cansu
Wernicke encephalopathy is an acute neurological problem resulting from thiamine deficiency and manifesting with mental confusion, oculomotor dysfunction, and ataxia. It is associated with alcohol dependence in adults. Preparatory factors include hyperemesis gravidarum, prolonged diarrhea, prolonged parental nutrition without vitamin support, absorption disorders, anorexia, cancer, and chemotherapy. Failure to consider the clinical findings and preparatory factors of this disease, which is rare in children, can delay diagnosis...
March 28, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29572747/severe-nasomaxillary-hypoplasia-binder-phenotype-on-prenatal-us-mri-an-important-marker-for-the-prenatal-diagnosis-of-chondrodysplasia-punctata
#16
Anna R Blask, Eva I Rubio, Kimberly A Chapman, Anne K Lawrence, Dorothy I Bulas
BACKGROUND: Chondrodysplasia punctata is a skeletal dysplasia caused by a diverse spectrum of etiologies, with outcomes ranging from antenatal demise to a normal life span. Prenatal detection can be challenging. OBJECTIVE: To review a series of cases of chondrodysplasia punctata associated with nasomaxillary hypoplasia, known as the Binder phenotype, and to highlight prenatal ultrasound and MRI findings, as well as postnatal MRI and radiographic findings. MATERIALS AND METHODS: We retrospectively reviewed ultrasound, MRI and radiographic imaging findings in postnatally confirmed cases of chondrodysplasia punctata from 2001 to 2017...
March 23, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29563707/ocular-manifestations-in-a-case-of-wernicke-s-encephalopathy-due-to-hyperemesis-gravidarum
#17
Namitha Rachel Mathew, Sudha G Menon, Mariam Mathew
Wernicke's Encephalopathy (WE) is a potentially devastating disorder, which if not diagnosed and treated at the earliest, could lead to dangerous neurological and ophthalmological complications. We report the ocular manifestations of WE in a pregnant woman with hyperemesis gravidarum.
January 2018: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29563502/placenta-and-appetite-genes-gdf15-and-igfbp7-are-associated-with-hyperemesis-gravidarum
#18
Marlena S Fejzo, Olga V Sazonova, J Fah Sathirapongsasuti, Ingileif B Hallgrímsdóttir, Vladimir Vacic, Kimber W MacGibbon, Frederic P Schoenberg, Nicholas Mancuso, Dennis J Slamon, Patrick M Mullin
Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3-2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications. Two loci, chr19p13...
March 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29560069/cannabinoid-hyperemesis-syndrome-public-health-implications-and-a-novel-model-treatment-guideline
#19
Jeff Lapoint, Seth Meyer, Charles K Yu, Kristi L Koenig, Roneet Lev, Sayone Thihalolipavan, Katherine Staats, Christopher A Kahn
Introduction: Cannabinoid hyperemesis syndrome (CHS) is an entity associated with cannabinoid overuse. CHS typically presents with cyclical vomiting, diffuse abdominal pain, and relief with hot showers. Patients often present to the emergency department (ED) repeatedly and undergo extensive evaluations including laboratory examination, advanced imaging, and in some cases unnecessary procedures. They are exposed to an array of pharmacologic interventions including opioids that not only lack evidence, but may also be harmful...
March 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29546743/secondary-adrenal-insufficiency-in-pregnancy-any-differences
#20
Stephan Petersenn
Secondary adrenal insufficiency may pose specific challenges during pregnancy. The interpretation of diagnostic tests is hindered by physiological adaptations of the HPA axis. Due the relevant increases in CBG, measurement of salivary cortisol may be preferable, but lacks sufficiently established cut-offs both for early-morning evaluation and during dynamic testing. Hydrocortisone should be used for replacement to avoid overexposure of the fetus, with dose adjustments according to clinical judgement. To account for increased free cortisol levels during the course of pregnancy, hydrocortisone may be increased by 5-7...
March 15, 2018: Minerva Endocrinologica
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