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https://www.readbyqxmd.com/read/28936162/rna-sequencing-analysis-reveals-a-regulatory-role-for-transcription-factor-fezf2-in-the-mature-motor-cortex
#1
Alison J Clare, Hollie E Wicky, Ruth M Empson, Stephanie M Hughes
Forebrain embryonic zinc finger (Fezf2) encodes a transcription factor essential for the specification of layer 5 projection neurons (PNs) in the developing cerebral cortex. As with many developmental transcription factors, Fezf2 continues to be expressed into adulthood, suggesting it remains crucial to the maintenance of neuronal phenotypes. Despite the continued expression, a function has yet to be explored for Fezf2 in the PNs of the developed cortex. Here, we investigated the role of Fezf2 in mature neurons, using lentiviral-mediated delivery of a shRNA to conditionally knockdown the expression of Fezf2 in the mouse primary motor cortex (M1)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28936106/long-term-psychological-health-among-individuals-pursuing-emerging-adulthood-type-pathways-in-the-1950s-and-1960s
#2
Alan Reifman, Timothy Oblad, Sylvia Niehuis
We analyzed data from the Wisconsin Longitudinal Study (N = 6390) to investigate how common an emerging adulthood-type lifestyle (e.g., delayed marriage and childbearing, pursuit of higher education) was in the late 1950s and early 1960s, and what the long-term psychological-health correlates were of such a lifestyle. Cluster analyses of marital, childbearing, educational, and occupational variables from 1957 (high school graduation) to 1964 generated six clusters that we labeled: fast-starters (early marriage and childbearing, little education beyond high school, virtually all employed), very-educated/partnered (mean educational attainment well into graduate school and among the earliest to get married), moderately educated/family oriented (mean years of education somewhat shy of a bachelor's degree, early marriage and childbearing), educated singles (late marriage and childbearing, if at all, averaging a bachelor's degree; most prototypical of emerging adulthood), work/military first (little education past high school, late marriage and childbearing), and military/professional aspiration (envisioning career requiring college education and pursuing one)...
June 2017: Journal of Adult Development
https://www.readbyqxmd.com/read/28936002/the-long-term-effects-of-self-esteem-on-depression-the-roles-of-alcohol-and-substance-uses-during-young-adulthood
#3
Kiwoong Park, Tse-Chuan Yang
Using the National Longitudinal Surveys of Youth 1979, this study examines the roles of alcohol and substance use as mediators in the mechanism between self-esteem and depression, and investigates whether the mechanism works for both men and women. Results demonstrate that alcohol and substance use during young adulthood mediates the effect of self-esteem on depression among men. Furthermore, self-esteem during young adulthood remains a determinant of high depression in middle adulthood. However, we did not find evidence to support that same mechanism among women...
2017: Sociological Quarterly
https://www.readbyqxmd.com/read/28935365/breast-development-and-disorders-in-the-adolescent-female
#4
REVIEW
Nirupama K De Silva
Breast development in the female is a process that becomes noticeable during puberty, and defines a girl's transition into adulthood. Various conditions can disrupt or alter the normal development, which may lead to abnormal breast changes and features. Further, the finding of a breast mass in adolescence can be unsettling to the patient and her family. While the majority of these breast changes and/or masses tend to be benign and self-limited, the appropriate evaluation is always warranted. This chapter will focus on the normal and abnormal development of breasts...
September 5, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28933877/the-developmental-course-of-community-service-across-the-transition-to-adulthood-in-a-national-u-s-sample
#5
Laura Wray-Lake, John Schulenberg, Katherine M Keyes, Jennifer Shubert
Despite the importance of community service for the well-being of individuals and communities, relatively little is known about the developmental course of community service during the transition to adulthood (TTA). This study tested competing hypotheses about change in community service across the TTA by estimating latent growth models from Ages 18 to 26 in a national U.S. SAMPLE: Analyses tested for cohort differences in community service and for individual differences in developmental trajectories by socioeconomic status, gender, grades, religiosity, race/ethnicity, college expectations, and college degree attainment...
September 21, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28931624/the-first-wave-of-t-lymphopoiesis-in-zebrafish-arises-from-aorta-endothelium-independent-of-hematopoietic-stem-cells
#6
Ye Tian, Jin Xu, Shachuan Feng, Sicong He, Shizheng Zhao, Lu Zhu, Wan Jin, Yimei Dai, Lingfei Luo, Jianan Y Qu, Zilong Wen
T lymphocytes are key cellular components of the adaptive immune system and play a central role in cell-mediated immunity in vertebrates. Despite their heterogeneities, it is believed that all different types of T lymphocytes are generated exclusively via the differentiation of hematopoietic stem cells (HSCs). Using temporal-spatial resolved fate-mapping analysis and time-lapse imaging, here we show that the ventral endothelium in the zebrafish aorta-gonad-mesonephros and posterior blood island, the hematopoietic tissues previously known to generate HSCs and erythromyeloid progenitors, respectively, gives rise to a transient wave of T lymphopoiesis independent of HSCs...
September 20, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28930056/developmentally-specific-associations-between-cnr1-genotype-and-cannabis-use-across-emerging-adulthood
#7
James R Ashenhurst, K Paige Harden, Travis T Mallard, William R Corbin, Kim Fromme
OBJECTIVE: Previous studies have found preliminary evidence for associations between common single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor gene CNR1 and cannabis use and dependence. The present study examined a set of eight independent SNPs in or near CNR1 in relation to cannabis use measured longitudinally across emerging adulthood. METHOD: Using latent growth curve modeling of 10 waves of longitudinal data spanning mean ages 18.4-23.8 years in a sample of non-Hispanic White individuals (n = 334), we tested if genotype at each CNR1 SNP was associated with both level and growth of cannabis use over time...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28921628/who-wins-in-the-weaning-process-juvenile-feeding-morphology-of-two-freshwater-mussel-species
#8
Rafael Araujo, Miquel Campos, Carles Feo, Catuxa Varela, Joaquín Soler, Paz Ondina
The global decline of freshwater mussels can be partially attributed to their complex life cycle. Their survival from glochidium to adulthood is like a long obstacle race, with juvenile mortality as a key critical point. Mass mortality shortly after entering into a juvenile state has been reported in both wild and captive populations, thus weakening the effective bivalve population. A similar phenomenon occurs during metamorphosis in natural and hatchery populations of juvenile marine bivalves. Based on a morphological analysis using scanning electron microscopy of newly formed juveniles of the freshwater species Margaritifera margaritifera (L...
September 18, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28918309/health-and-wellbeing-during-transition-to-adulthood-for-young-people-with-intellectual-disabilities-a-qualitative-study
#9
Genevieve Young-Southward, Sally-Ann Cooper, Christopher Philo
BACKGROUND: Transition to adulthood may have negative consequences for health and wellbeing in individuals with intellectual disabilities (ID), but this aspect of transition has received little investigation. This qualitative study aimed to explore the transition experiences of individuals with ID from their own perspectives, and from that of their parents, in order to identify health or wellbeing implications of transition. METHOD: Semi-structured interviews were conducted with 17 young people with mild, moderate and severe ID aged 16-27 years and with 23 parents of young people with mild, moderate, severe and profound ID aged 16-26 years...
September 14, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28913676/the-cost-of-being-cool-how-adolescent-pseudomature-behavior-maps-onto-adult-adjustment
#10
Leslie Gordon Simons, Tara E Sutton, Sarah Shannon, Mark T Berg, Frederick X Gibbons
During adolescence, one's status among peers is a major concern. Such status is often largely a function of popularity and establishing oneself as "cool." While there are conventional avenues to achieving status among adolescents, engaging in adult-like, or pseudomature, behaviors such as substance use or sexual activity is a frequent occurrence. Although past research has examined the consequences of adolescent delinquency, what remains unclear is the long-term fate of adolescents who are both popular and antisocial...
September 15, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28904593/criteria-for-the-transition-to-adulthood-developmental-features-of-emerging-adulthood-and-views-of-the-future-among-greek-studying-youth
#11
Evangelia Galanaki, Sophie Leontopoulou
This study investigated emerging adulthood and transition to adulthood in Greece, a highly underresearched issue in this country. Participants were 784 university students aged 17.5-27.5 years. Criteria for the transition to adulthood, developmental features of emerging adulthood, perceived adult status, views of the future (optimism), and sociodemographic variables were assessed. The results support the existence of emerging adulthood as a distinct life period in Greece. More than two thirds of the sample were self-perceived emerging adults...
August 2017: Europe's journal of psychology
https://www.readbyqxmd.com/read/28895859/evidence-supporting-the-effectiveness-of-transition-programs-for-youth-with-special-health-care-needs
#12
Ronald Feinstein, Cindy Rabey, Mariecel Pilapil
More than 90% of adolescents and young adults with chronic medical conditions will survive into adulthood. Transitioning from pediatric to adult health care services for these individuals has often times been associated with deterioration of their health and Quality of Life. Separation from their pediatric provider and lack of preparedness of the adult health care system has been identified as major barriers in preventing the successful transition of these individuals. The purpose of this review is to summarize the available data related to transitioning adolescents and young adults (AYA) with special health care needs into the adult health care system...
August 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28895262/physical-and-mental-health-of-young-people-with-and-without-intellectual-disabilities-cross-sectional-analysis-of-a-whole-country-population
#13
G Young-Southward, E Rydzewska, C Philo, S-A Cooper
BACKGROUND: Transition to adulthood may be a period of vulnerability for health for individuals with intellectual disabilities. No large-scale studies have compared the health of individuals with and without intellectual disabilities undergoing transition. The aims of this study were (1) to compare health during transition for individuals with and without intellectual disabilities across a whole country population and (2) to establish whether transition is associated with health in the population with intellectual disabilities...
October 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28888150/gender-differences-in-trajectories-of-alcohol-use-from-ages-13-to-33-across-latina-o-ethnic-groups
#14
Michael D Niño, Tianji Cai, Xóchitl Mota-Back, Joseph Comeau
BACKGROUND: Research examining alcohol use trajectories among Latina/os is scarce. Further, prior findings on alcohol use by ethnic group and gender is mixed. The purpose of this study was twofold: (a.) to examine developmental trajectories for two types of alcohol (drunkenness and heavy drinking) use across four Latina/o ethnic groups (Cubans, Puerto Ricans, Central/South American, and Mexican Americans) and, (b.) to examine the role of gender and ethnicity in developmental trajectories of drunkenness and heavy drinking among Latina/os...
September 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28886576/change-in-college-students-perceived-parental-permissibility-of-alcohol-use-and-its-relation-to-college-drinking
#15
Brian H Calhoun, Jennifer L Maggs, Eric Loken
College students who perceive their parents to hold permissive views about their alcohol use engage in heavier drinking. However, few studies have assessed perceived parental permissibility of alcohol use (PPP) longitudinally across the later college years, and few have assessed variation in changes in PPP and whether or not these changes differentially predict drinking. This study assessed whether PPP changed across college and used two approaches to determine whether PPP predicted binge drinking frequency and peak drinking...
August 31, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28875247/-it-was-supposed-to-be-a-onetime-thing-experiences-of-romantic-and-sexual-relationship-typologies-among-young-gay-bisexual-and-other-men-who-have-sex-with-men
#16
Stephen P Sullivan, Emily S Pingel, Rob Stephenson, José A Bauermeister
Young gay, bisexual, and other men who have sex with men (MSM) are at elevated risk for HIV infection, highlighting the need to understand the elements of prevention and risk associated with their relationships. We employed a phenomenological approach to explore how young MSM become involved in different romantic and sexual experiences. We analyzed 28 semi-structured interviews conducted with young MSM living in Michigan. Using a phenomenological approach, we analyzed the data using an inductive coding strategy and thematic analysis...
September 5, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28874224/adolescent-mental-health-and-behavioural-predictors-of-being-neet-a-prospective-study-of-young-adults-not-in-employment-education-or-training
#17
L Rodwell, H Romaniuk, W Nilsen, J B Carlin, K J Lee, G C Patton
BACKGROUND: Young adults who are not in employment, education, or training (NEET) are at risk of long-term economic disadvantage and social exclusion. Knowledge about risk factors for being NEET largely comes from cross-sectional studies of vulnerable individuals. Using data collected over a 10-year period, we examined adolescent predictors of being NEET in young adulthood. METHODS: We used data on 1938 participants from the Victorian Adolescent Health Cohort Study, a community-based longitudinal study of adolescents in Victoria, Australia...
September 6, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28865434/association-between-life-course-socioeconomic-position-and-inflammatory-biomarkers-in-older-age-a-nationally-representative-cohort-study-in-taiwan
#18
Yu-Hsuan Lin, Min-Hua Jen, Kuo-Liong Chien
BACKGROUND: Evidence of an association between low socioeconomic position (SEP) and inflammatory markers is scant. This study aimed to examine how life-course SEP predicted C-reactive protein (CRP) and interleukin (IL-6) in older age from a national cohort. METHODS: We collected data from 1036 participants in the Social Environment and Biomarkers of Aging Study in Taiwan. Four SEP time points, childhood, young adulthood, active professional life, and older age were measured retrospectively...
September 2, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28857191/transitions-in-sleep-problems-from-late-adolescence-to-young-adulthood-a-longitudinal-analysis-of-the-effects-of-peer-victimization
#19
Ling-Yin Chang, Hsing-Yi Chang, Linen Nymphas Lin, Chi-Chen Wu, Lee-Lan Yen
Adolescence is a developmental period with high vulnerability to sleep problems. However, research identifying distinct patterns and underlying determinants of sleep problems is scarce. This study investigated discrete subgroups of, changes in, and stability of sleep problems. We also examined whether peer victimization influenced sleep problem subgroups and transitions in patterns of sleep problems from late adolescence to young adulthood. Sex differences in the effects of peer victimization were also explored...
August 31, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28845696/profiles-of-family-routines-during-adolescence-associated-with-profiles-of-health-behaviors-in-young-adulthood
#20
Caitlin C Abar, Kaitlyn Koban, Sarah Farnett, Kayla Mendola, Gabrielle Clark
This study examined associations between profiles of family routines in early adolescence and profiles of health behaviors during young adulthood. In a sample of 4565 individuals, latent transition analysis indicated individuals in a family characterized by low involvement in adolescence were most likely, across classes, to demonstrate a profile characterized by substance use in young adulthood. The high-involvement class during adolescence was least likely to be a substance user but was relatively likely to be in the poor diet and exercise class during young adulthood...
August 1, 2017: Journal of Health Psychology
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