Konstantina Kyritsi, Nan Wu, Tianhao Zhou, Guido Carpino, Leonardo Baiocchi, Lindsey Kennedy, Lixian Chen, Ludovica Ceci, Alison Ann Meyer, Nipuni Barupala, Antonio Franchitto, Paolo Onori, Burcin Ekser, Eugenio Gaudio, Chaodong Wu, Corinn Marakovits, Sanjukta Chakraborty, Heather Francis, Shannon Glaser, Gianfranco Alpini
BACKGROUND: Alcohol-related liver disease (ALD) is characterized by ductular reaction (DR), liver inflammation, steatosis, fibrosis, and cirrhosis. The secretin (Sct)/secretin receptor (SR) axis (expressed only by cholangiocytes) regulates liver phenotypes in cholestasis. We evaluated the role of Sct signaling on ALD phenotypes. METHODS: We used male wild-type and Sct-/- mice fed a control diet (CD) or ethanol (EtOH) for 8 wk. Changes in liver phenotypes were measured in mice, female/male healthy controls, and patients with alcoholic cirrhosis...
January 9, 2023: Cell & Bioscience