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Keywords Na + /taurocholate cotransport...

Na + /taurocholate cotransporting polypeptide

https://read.qxmd.com/read/38429619/evolutionary-analysis-of-slc10-family-members-and-insights-into-function-and-expression-regulation-of-lamprey-ntcp
#1
JOURNAL ARTICLE
Yingying Zhu, Qipeng Zhang, Jilong Pan, Tiesong Li, Hao Wang, Jindi Liu, Lei Qian, Ting Zhu, Yue Pang, Qingwei Li, Yan Chi
The Na ( +)-taurocholate cotransporting polypeptide (NTCP) is a member of the solute carrier family 10 (SLC10), which consists of 7 members (SLC10a1-SLC10a7). NTCP is a transporter localized to the basolateral membrane of hepatocytes and is primarily responsible for the absorption of bile acids. Although mammalian NTCP has been extensively studied, little is known about the lamprey NTCP (L-NTCP). Here we show that L-NTCP follows the biological evolutionary history of vertebrates, with conserved domain, motif, and similar tertiary structure to higher vertebrates...
March 2, 2024: Fish Physiology and Biochemistry
https://read.qxmd.com/read/38362143/chishao-paeoniae-radix-rubra-alleviates-intra-hepatic-cholestasis-by-modulating-ntcp-in-rats
#2
JOURNAL ARTICLE
Xiaoqi Sun, Jing Fang, Nanyuan Fang
Background: Cholestasis is a common pathological manifestation dominated by accumulation of potentially toxic biliary compounds. Na+ -taurocholate cotransporting polypeptide (NTCP) plays a critical role in protection from cholestasis and can be targeted therapeutically. Chishao ( Paeoniae Radix Rubra ) is a clinically efficacious agent for treating cholestasis, but the underlying mechanism has not been fully clarified. Objective: To evaluate the effects of Chishao on the expression of NTCP in rats with alpha-naphthylisothiocyanate (ANIT)-induced cholestasis...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38297280/znf148-inhibits-hbv-replication-by-downregulating-rxr%C3%AE-transcription
#3
JOURNAL ARTICLE
Xinyan Yao, Kexin Xu, Nana Tao, Shengtao Cheng, Huajian Chen, Dapeng Zhang, Minli Yang, Ming Tan, Haibo Yu, Peng Chen, Zongzhu Zhan, Siyi He, Ranran Li, Chunduo Wang, Daiqing Wu, Jihua Ren
BACKGROUND: Progressive hepatitis B virus (HBV) infection can result in cirrhosis, hepatocellular cancer, and chronic hepatitis. While antiviral drugs that are now on the market are efficient in controlling HBV infection, finding a functional cure is still quite difficult. Identifying host factors involved in regulating the HBV life cycle will contribute to the development of new antiviral strategies. Zinc finger proteins have a significant function in HBV replication, according to earlier studies...
January 31, 2024: Virology Journal
https://read.qxmd.com/read/38230695/targeting-bile-salt-homeostasis-in-biliary-diseases
#4
JOURNAL ARTICLE
David C Trampert, Roni F Kunst, Stan F J van de Graaf
PURPOSE OF REVIEW: Advances in the understanding of bile salt synthesis, transport and signalling show the potential of modulating bile salt homeostasis as a therapeutic strategy in cholestatic liver diseases. Here, recent developments in (pre)clinical research in this field is summarized and discussed. RECENT FINDINGS: Inhibition of the apical sodium-dependent bile salt transporter (ASBT) and Na+-taurocholate cotransporting polypeptide (NTCP) seems effective against cholestatic liver diseases, as well as Farnesoid X receptor (FXR) agonism or a combination of both...
January 11, 2024: Current Opinion in Gastroenterology
https://read.qxmd.com/read/37872088/-analysis-of-the-serum-bile-acid-profile-to-facilitate-diagnosis-and-differential-diagnosis-of-na-taurocholate-cotransporting-polypeptide-deficiency
#5
JOURNAL ARTICLE
M Deng, R Liu, L J Deng, R Chen, M E Cai, G Z Lin, J W Qiu, Y Z Song
Objective: This study focuses on Na(+)-taurocholate cotransporting polypeptide (NTCP) deficiency to analyze and investigate the value of the serum bile acid profile for facilitating the diagnosis and differential diagnosis. Methods: Clinical data of 66 patients with cholestatic liver diseases (CLDs) diagnosed and treated in the Department of Pediatrics of the First Affiliated Hospital of Jinan University from early April 2015 to the end of December 2021 were collected, including 32 cases of NTCP deficiency (16 adults and 16 children), 16 cases of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), 8 cases of Alagille syndrome, and 10 cases of biliary atresia...
September 20, 2023: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/37815745/mir-143-3p-fndc5-axis-a-novel-regulator-of-insulin-sensitivity
#6
JOURNAL ARTICLE
Biao Li, Ying Dong, Siyuan Hu, Tiancai Liu
PURPOSE: Insulin resistance is a key hallmark in type 2 diabetes. In recent decades, there have been numerous studies of the causes of insulin resistance. microRNAs (miRNAs) participate in the regulation of multiple aspects of energy metabolism and miR-143-3p has been shown to induce insulin resistance. We aimed to predict the downstream targets of miR-143-3p and found a miR-143-3p binding site on the 3'-untranslated region of FNDC5 (Fibronectin type III domain containing 5) mRNA. METHODS: We first confirmed that FNDC5 mRNA is a target of miR-143-3p using a double luciferase experiment, then constructed a prokaryotic expression system for the mature form of FNDC5, irisin, and expressed and purified irisin protein...
October 10, 2023: Endocrine
https://read.qxmd.com/read/37517004/analysis-of-hepatocellular-carcinoma-associated-with-hepatitis-b-virus
#7
REVIEW
Litao Zheng
The hepatitis B virus (HBV) is considered one of the main driving forces in the development of hepatocellular carcinoma (HCC). Human HBV is a partially double-stranded DNA (dsDNA) virus consisting of approximately 3.2 kbp. HBV predominantly infects hepatocytes via the receptor sodium taurocholate cotransporting polypeptide (NTCP) and coreceptor hepatic proteoglycan. The replication of HBV in hepatocytes leads to apoptosis while simultaneously leading to cirrhosis and cancer. Although the integration of dsDNA into the hepatocyte genome seems to be the main cause of mutation, since the discovery of their function, viral proteins have been shown to regulate the P53 pathway or P13K/AKT pathway to prevent host cell apoptosis, causing uncontrolled proliferation of liver cells leading to the formation of solid tumours...
July 30, 2023: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/37425215/cell-based-bsep-trans-inhibition-a-novel-non-invasive-test-for-diagnosis-of-antibody-induced-bsep-deficiency
#8
JOURNAL ARTICLE
Jan Stindt, Carola Dröge, Elke Lainka, Simone Kathemann, Eva-Doreen Pfister, Ulrich Baumann, Amelie Stalke, Enke Grabhorn, Mohammad Ali Shagrani, Yael Mozer-Glassberg, Jane Hartley, Marianne Wammers, Caroline Klindt, Paulina Philippski, Roman Liebe, Diran Herebian, Ertan Mayatepek, Thomas Berg, Anjona Schmidt-Choudhury, Constanze Wiek, Helmut Hanenberg, Tom Luedde, Verena Keitel
BACKGROUND & AIMS: Antibody-induced bile salt export pump deficiency (AIBD) is an acquired form of intrahepatic cholestasis, which may develop following orthotopic liver transplantation (OLT) for progressive familial intrahepatic cholestasis type 2 (PFIC-2). Approximately 8-33% of patients with PFIC-2 who underwent a transplant develop bile salt export pump (BSEP) antibodies, which trans-inhibit this bile salt transporter from the extracellular, biliary side. AIBD is diagnosed by demonstration of BSEP-reactive and BSEP-inhibitory antibodies in patient serum...
July 2023: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/37103224/interactions-of-na-taurocholate-cotransporting-polypeptide-with-host-cellular-proteins-upon-hepatitis-b-and-d-virus-infection-novel-potential-targets-for-antiviral-therapy
#9
REVIEW
Dariusz Zakrzewicz, Joachim Geyer
Na+ /taurocholate cotransporting polypeptide (NTCP) is a member of the solute carrier (SLC) family 10 transporters (gene symbol SLC10A1 ) and is responsible for the sodium-dependent uptake of bile salts across the basolateral membrane of hepatocytes. In addition to its primary transporter function, NTCP is the high-affinity hepatic receptor for hepatitis B (HBV) and hepatitis D (HDV) viruses and, therefore, is a prerequisite for HBV/HDV virus entry into hepatocytes. The inhibition of HBV/HDV binding to NTCP and internalization of the virus/NTCP receptor complex has become a major concept in the development of new antiviral drugs called HBV/HDV entry inhibitors...
April 28, 2023: Biological Chemistry
https://read.qxmd.com/read/37058078/farnesoid-x-receptor-alpha-ligands-inhibit-hdv-in-vitro-replication-and-virion-infectivity
#10
JOURNAL ARTICLE
Anne-Flore Legrand, Julie Lucifora, Benoît Lacombe, Camille Ménard, Maud Michelet, Adrien Foca, Pauline Abrial, Anna Salvetti, Michel Rivoire, Vincent Lotteau, David Durantel, Patrice André, Christophe Ramière
BACKGROUND AND AIMS: HDV, a satellite of HBV, is responsible for the most severe form of human viral hepatitis, for which curative therapy is still awaited. Both HBV and HDV use the hepatic transporter of bile acids (ie, Na+-taurocholate cotransporting polypeptide) to enter hepatocytes. We have previously shown that ligands of the farnesoid-X-receptor alpha (FXR), a master regulator of bile acids metabolism, inhibit HBV replication. Here we asked whether FXR ligands can also control HDV infection...
May 1, 2023: Hepatology Communications
https://read.qxmd.com/read/37031879/dietary-cholesterol-drives-the-development-of-non-alcoholic-steatohepatitis-by-altering-gut-microbiota-mediated-bile-acid-metabolism-in-high-fat-diet-fed-mice
#11
JOURNAL ARTICLE
Xuebin Gao, Xiaozhuan Lin, Yan Xin, Xuan Zhu, Xiang Li, Ming Chen, Zhigang Huang, Honghui Guo
Non-alcoholic fatty liver disease (NAFLD) is the most widespread chronic liver disorder globally. Unraveling the pathogenesis of simple fatty liver to non-alcoholic steatohepatitis (NASH) has important clinical significance for improving the prognosis of NAFLD. Here, we explored the role of a high-fat diet alone or combined with high cholesterol in causing NASH progression. Our results demonstrated that high dietary cholesterol intakes accelerate the progression of spontaneous NAFLD and induces liver inflammation in mice...
April 7, 2023: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/36624475/knockout-of-secretin-ameliorates-biliary-and-liver-phenotypes-during-alcohol-induced-hepatotoxicity
#12
JOURNAL ARTICLE
Konstantina Kyritsi, Nan Wu, Tianhao Zhou, Guido Carpino, Leonardo Baiocchi, Lindsey Kennedy, Lixian Chen, Ludovica Ceci, Alison Ann Meyer, Nipuni Barupala, Antonio Franchitto, Paolo Onori, Burcin Ekser, Eugenio Gaudio, Chaodong Wu, Corinn Marakovits, Sanjukta Chakraborty, Heather Francis, Shannon Glaser, Gianfranco Alpini
BACKGROUND: Alcohol-related liver disease (ALD) is characterized by ductular reaction (DR), liver inflammation, steatosis, fibrosis, and cirrhosis. The secretin (Sct)/secretin receptor (SR) axis (expressed only by cholangiocytes) regulates liver phenotypes in cholestasis. We evaluated the role of Sct signaling on ALD phenotypes. METHODS: We used male wild-type and Sct-/- mice fed a control diet (CD) or ethanol (EtOH) for 8 wk. Changes in liver phenotypes were measured in mice, female/male healthy controls, and patients with alcoholic cirrhosis...
January 9, 2023: Cell & Bioscience
https://read.qxmd.com/read/36497071/a-high-hepatic-uptake-of-conjugated-bile-acids-promotes-colorectal-cancer-associated-liver-metastasis
#13
JOURNAL ARTICLE
Zongmei Zheng, Jiao Wei, Xinxin Hou, Fengjing Jia, Zhaozhou Zhang, Haidong Guo, Fuwen Yuan, Feng He, Zunji Ke, Yan Wang, Ling Zhao
The liver is the most common site for colorectal cancer (CRC)-associated metastasis. There remain unsatisfactory medications in liver metastasis given the incomplete understanding of pathogenic mechanisms. Herein, with an orthotopic implantation model fed either regular or high-fat diets (HFD), more liver metastases were associated with an expansion of conjugated bile acids (BAs), particularly taurocholic acid (TCA) in the liver, and an increased gene expression of Na+ -taurocholate cotransporting polypeptide (NTCP)...
November 28, 2022: Cells
https://read.qxmd.com/read/36402308/novel-nitroxide-bile-acid-conjugates-inform-substrate-requirements-for-human-bile-acid-transporters
#14
JOURNAL ARTICLE
Melissa Metry, Nathaniel D A Dirda, Jean-Pierre Raufman, James E Polli, Joseph P Y Kao
Transport of bile acids within the enterohepatic circulation from the liver to the intestines via the gallbladder and back to the liver via the portal vein plays a critical role in bile acid regulation and homeostasis. Deficiency of fibroblast growth factor 19 (FGF19), a hormone whose role is to suppress de novo hepatic bile acid synthesis to maintain homeostatic levels, results in bile acid diarrhea (BAD). FGF19 also modulates gallbladder motility so that bile acids are concentrated in the gallbladder until postprandial contraction...
January 1, 2023: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/36374094/hepatitis-b-virus-x-protein-stimulates-hepatitis-c-virus-hcv-replication-by-protecting-hcv-core-protein-from-e6ap-mediated-proteasomal-degradation
#15
JOURNAL ARTICLE
Hyunyoung Yoon, Jiwoo Han, Kyung Lib Jang
Most clinical and experimental studies have suggested that hepatitis C virus (HCV) is dominant over hepatitis B virus (HBV) during coinfection, although the underlying mechanism remains unclear. In this study, we found that the HBV X protein (HBx) upregulates the levels of the HCV core protein to stimulate HCV replication during coinfection in human hepatoma cells. For this purpose, HBx upregulated both the protein levels and enzyme activities of cellular DNA methyltransferase 1 (DNMT1) and DNMT3b, and this subsequently reduced the expression levels of the E6-associated protein (E6AP), an E3 ligase of the HCV core protein, via DNA methylation...
November 14, 2022: Microbiology Spectrum
https://read.qxmd.com/read/36249786/kaempferol-attenuates-nonalcoholic-steatohepatitis-by-regulating-serum-and-liver-bile-acid-metabolism
#16
JOURNAL ARTICLE
Yifei Lu, Mingmei Shao, Caiyun Zhang, Hongjiao Xiang, Junmin Wang, Tao Wu, Guang Ji
Objective: Changes in bile acids (BAs) are increasingly recognized as potential targets for non-alcoholic steatohepatitis (NASH). Kaempferol has been proved to be anti-inflammatory and reduce the disorder of lipid metabolism. In order to analyze the BA profile in NASH mice and determine the predictive biomarkers of kaempferol treatment, serum-targeted metabolomics and liver tissue RNA sequencing (RNA-seq) were carried out. Design: Six normal control mice (NC group), eight HFD-fed mice (HFD group), and eight kaempferol-treated HFD-fed mice (HFD + KP group) were included in the present study...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/36160754/systemic-asbt-inactivation-protects-against-liver-damage-in-obstructive-cholestasis-in-mice
#17
JOURNAL ARTICLE
Roni F Kunst, Dirk R de Waart, Frank Wolters, Suzanne Duijst, Esther W Vogels, Isabelle Bolt, Joanne Verheij, Ulrich Beuers, Ronald P J Oude Elferink, Stan F J van de Graaf
Background & Aims: Non-absorbable inhibitors of the apical sodium-dependent bile acid transporter (ASBT; also called ileal bile acid transporter [IBAT]) are recently approved or in clinical development for multiple cholestatic liver disorders and lead to a reduction in pruritus and (markers for) liver injury. Unfortunately, non-absorbable ASBT inhibitors (ASBTi) can induce diarrhoea or may be ineffective if cholestasis is extensive and largely precludes intestinal excretion of bile acids...
November 2022: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/36060770/establishment-of-a-human-cell-line-with-a-surface-display-system-for-screening-and-optimizing-na-taurocholate-cotransporting-polypeptide-binding-peptides
#18
JOURNAL ARTICLE
Pei-Yun Wang, Xue Yang, Lin Guo, Yu-Wei Wang, Wen-Lu Zhang, Yu-Xue Sun, Jie Li, Chun-Yang Gan, Shao-Yuan Long, Jia-Jun Liu, Shu-Ying Fan, Ai-Long Huang, Jie-Li Hu
One of the most desirable targets for HBV medications is the sodium taurocholate cotransporting polypeptide (NTCP), an entry receptor for the hepatitis B virus (HBV). N-myristoylated preS1 2-48 (Myrcludex B or Hepcludex), an NTCP-binding peptide from the large surface protein of HBV, has been developed as the first-in-class entry inhibitor. However, its relatively large molecular weight contributes to increased immunogenicity and antibody production. As a result, it is preferable to look for an NTCP-binding peptide with a smaller size...
2022: Frontiers in Microbiology
https://read.qxmd.com/read/35955590/free-cholesterol-affects-the-function-and-localization-of-human-na-taurocholate-cotransporting-polypeptide-ntcp-and-organic-cation-transporter-1-oct1
#19
JOURNAL ARTICLE
Jessica Y Idowu, Bruno Hagenbuch
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with obesity. They are accompanied by increased levels of free cholesterol in the liver. Most free cholesterol resides within the plasma membrane. We assessed the impact of adding or removing free cholesterol on the function and localization of two hepatocellular uptake transporters: the Na+ /taurocholate cotransporting polypeptide (NTCP) and the organic cation transporter 1 (OCT1). We used a cholesterol-MCD complex (cholesterol) to add cholesterol and methyl-β-cyclodextrin (MCD) to remove cholesterol...
July 30, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35806468/hepatic-expression-of-the-na-taurocholate-cotransporting-polypeptide-is-independent-from-genetic-variation
#20
JOURNAL ARTICLE
Roman Tremmel, Anne T Nies, Barbara A C van Eijck, Niklas Handin, Mathias Haag, Stefan Winter, Florian A Büttner, Charlotte Kölz, Franziska Klein, Pascale Mazzola, Ute Hofmann, Kathrin Klein, Per Hoffmann, Markus M Nöthen, Fabienne Z Gaugaz, Per Artursson, Matthias Schwab, Elke Schaeffeler
The hepatic Na+ -taurocholate cotransporting polypeptide NTCP/ SLC10A1 is important for the uptake of bile salts and selected drugs. Its inhibition results in increased systemic bile salt concentrations. NTCP is also the entry receptor for the hepatitis B/D virus. We investigated interindividual hepatic SLC10A1 /NTCP expression using various omics technologies. SLC10A1 /NTCP mRNA expression/protein abundance was quantified in well-characterized 143 human livers by real-time PCR and LC-MS/MS-based targeted proteomics...
July 5, 2022: International Journal of Molecular Sciences
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