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https://www.readbyqxmd.com/read/28089515/navigation-through-the-plasma-membrane-molecular-landscape-shapes-random-organelle-movement
#1
Alison R Dun, Gabriel J Lord, Rhodri S Wilson, Deirdre M Kavanagh, Katarzyna I Cialowicz, Shuzo Sugita, Seungmee Park, Lei Yang, Annya M Smyth, Andreas Papadopulos, Colin Rickman, Rory R Duncan
Eukaryotic plasma membrane organization theory has long been controversial, in part due to a dearth of suitably high-resolution techniques to probe molecular architecture in situ and integrate information from diverse data streams [1]. Notably, clustered patterning of membrane proteins is a commonly conserved feature across diverse protein families (reviewed in [2]), including the SNAREs [3], SM proteins [4, 5], ion channels [6, 7], and receptors (e.g., [8]). Much effort has gone into analyzing the behavior of secretory organelles [9-13], and understanding the relationship between the membrane and proximal organelles [4, 5, 12, 14] is an essential goal for cell biology as broad concepts or rules may be established...
January 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28073345/reasons-for-faculty-departures-from-an-academic-medical-center-a-survey-and-comparison-across-faculty-lines
#2
Sabine C Girod, Magali Fassiotto, Roseanne Menorca, Henry Etzkowitz, Sherry M Wren
BACKGROUND: Faculty departure can present significant intellectual costs to an institution. The authors sought to identify the reasons for clinical and non-clinical faculty departures at one academic medical center (AMC). METHOD: In May and June 2010, the authors surveyed 137 faculty members who left a west coast School of Medicine (SOM) between 1999 and 2009. In May and June 2015, the same survey was sent to 40 faculty members who left the SOM between 2010-2014, for a total sample size of 177 former faculty members...
January 10, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28068935/qualitative-insights-into-implementation-processes-and-outcomes-of-a-randomized-trial-on-peer-support-and-hiv-care-engagement-in-rakai-uganda
#3
April Monroe, Gertrude Nakigozi, William Ddaaki, Jeremiah Mulamba Bazaale, Ronald H Gray, Maria J Wawer, Steven J Reynolds, Caitlin E Kennedy, Larry W Chang
BACKGROUND: People living with human immunodeficiency virus (HIV) who have not yet initiated antiretroviral therapy (ART) can benefit from being engaged in care and utilizing preventive interventions. Community-based peer support may be an effective approach to promote these important HIV services. METHODS: After conducting a randomized trial of the impact of peer support on pre-ART outcomes, we conducted a qualitative evaluation to better understand trial implementation, processes, and results...
January 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28064125/effects-of-cultural-brokering-on-individual-wellbeing-and-family-dynamics-among-immigrant-youth
#4
Vanja Lazarevic
Over 90% of immigrant youth help their parents navigate the mainstream US culture, a process known as cultural brokering. Past research has indicated that brokering can often have negative effects on development of immigrant youth and their families. The current study builds on the past literature by examining how various aspects of brokering may impact individual wellbeing and family dynamics among first generation immigrant and refugee youth from Eastern Europe (N = 197, Mage = 22.93 (SD = 2.89), 63...
January 5, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/27997306/ergonomic-assessment-of-selected-workstations-on-a-merchant-ship
#5
Agata Krystosik-Gromadzińska
In this study, we describe some of the key ergonomic factors within the engine room, the navigation bridge, and other locations of a merchant ship. Ergonomic assessments were carried out on a crew of a merchant ship. This study examines the importance of factors such as noise, vibration, heat radiation (in machinery areas), psychological stress and the ergonomics of the physical arrangement of the navigation bridge. It also addresses the effect of working in confined areas for a long duration and the need to process large amounts of data, decision making, and the influence of specific operating conditions in different areas of a ship...
December 20, 2016: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/27958724/engineering-an-artificial-flavoprotein-magnetosensor
#6
Chris Bialas, Lauren E Jarocha, Kevin B Henbest, Tilo M Zollitsch, Goutham Kodali, Christiane R Timmel, Stuart R Mackenzie, P Leslie Dutton, Christopher C Moser, P J Hore
Migratory birds use the Earth's magnetic field as a source of navigational information. This light-dependent magnetic compass is thought to be mediated by cryptochrome proteins in the retina. Upon light activation, electron transfer between the flavin adenine dinucleotide cofactor and tryptophan residues leads to the formation of a spin-correlated radical pair, whose subsequent fate is sensitive to external magnetic fields. To learn more about the functional requirements of this complex chemical compass, we have created a family of simplified, adaptable proteins-maquettes-that contain a single tryptophan residue at different distances from a covalently bound flavin...
December 28, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27940891/researchers-regulators-and-sponsors-views-on-pediatric-clinical-trials-a-multinational-study
#7
Pathma D Joseph, Jonathan C Craig, Allison Tong, Patrina H Y Caldwell
BACKGROUND AND OBJECTIVE: The last decade has seen dramatic changes in the regulatory landscape to support more trials involving children, but child-specific challenges and inequitable conduct across income regions persist. The goal of this study was to describe the attitudes and opinions of stakeholders toward trials in children, to inform additional strategies to promote more high-quality, relevant pediatric trials across the globe. METHODS: Key informant semi-structured interviews were conducted with stakeholders (researchers, regulators, and sponsors) who were purposively sampled from low- to middle-income countries and high-income countries...
October 2016: Pediatrics
https://www.readbyqxmd.com/read/27933536/genetic-dissection-of-variation-in-hippocampal-intra-and-infrapyramidal-mossy-fibers-in-the-mouse
#8
Anna Delprato, Wim E Crusio
This chapter describes the genetic analysis of a morphometric neuroanatomic trait. We used the extended BXD family of recombinant inbred mouse strains with the intent to analyze the genetic bases of heritable differences in hippocampal neurocircuitry and to identify Quantitative Trait Loci that underlie these variations. A detailed description of a GeneNetwork analysis is provided using data for the intra- and infrapyramidal mossy fiber (IIPMF) terminal fields which are strongly correlated with spatial navigation/radial maze learning...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27931533/care-transition-interventions-for-children-with-asthma-in-the-emergency-department
#9
REVIEW
Molly A Martin, Valerie G Press, Sharmilee M Nyenhuis, Jerry A Krishnan, Kim Erwin, Giselle Mosnaim, Helen Margellos-Anast, S Margaret Paik, Stacy Ignoffo, Michael McDermott
The emergency department (ED) is a critical point of identification and treatment for some of the most high-risk children with asthma. This review summarizes the evidence regarding care transition interventions originating in the ED for children with uncontrolled asthma, with a focus on care coordination and self-management education. Although many interventions on care transition for pediatric asthma have been tested, only a few were actually conducted in the ED setting. Most of these targeted both care coordination and self-management education but ultimately did not improve attendance at follow-up appointments with primary care providers, improve asthma control, or reduce health care utilization...
December 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27925326/navigating-physical-activity-engagement-following-a-diagnosis-of-cancer-a-qualitative-exploration
#10
C Cummins, N M Kayes, J Reeve, G Smith, R MacLeod, K M McPherson
This qualitative descriptive study explored cancer survivors' experiences of barriers and facilitators to undertaking physical activity to inform how services and professionals might offer better support. Purposive and theoretical sampling was used to recruit 25 people who were up to 5 years post-cancer diagnosis. Participants took part in face to face, semi-structured interviews, and transcripts were analysed using thematic analysis. The analysis identified five interrelated themes which represented cancer survivors' views: 1) You're on your own-a sense of abandonment post-treatment, and lack of sufficient and tailored information; 2) Dis-ease-disruption to self and identity, and a heightened awareness of physical self and fragility; 3) Becoming acclimatised-physical activity in the face of treatment-related side effects and residual impairment; 4) Importance of others-encouragement and support from health professionals, family and friends, and cancer-specific exercise groups; 5) Meanings people ascribed to physical activity-these were central and could help or hinder engagement...
December 7, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27909792/exploring-the-rationale-experience-and-impact-of-using-cancer-information-and-support-cis-services-an-international-qualitative-study
#11
Anna Boltong, Martin Ledwick, Kevin Babb, Clare Sutton, Anna Ugalde
PURPOSE: The aim of this study was to develop an in-depth understanding of the rationale, experiences, evaluation and outcomes of using Cancer Information and Support (CIS) services in Australia, the UK and USA. METHODS: Semi-structured interviews were used to gather data between November 2015 and January 2016. Telephone interviews were recorded, de-identified, transcribed and thematically analysed. Ten users from each of three international CIS services (n = 30 in total) were recruited...
December 1, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27895577/fus1-ko-mouse-as-a-model-of-oxidative-stress-mediated-sporadic-alzheimer-s-disease-circadian-disruption-and-long-term-spatial-and-olfactory-memory-impairments
#12
Guillermo Coronas-Samano, Keeley L Baker, Winston J T Tan, Alla V Ivanova, Justus V Verhagen
Insufficient advances in the development of effective therapeutic treatments of sporadic Alzheimer's Disease (sAD) to date are largely due to the lack of sAD-relevant animal models. While the vast majority of models do recapitulate AD's hallmarks of plaques and tangles by virtue of tau and/or beta amyloid overexpression, these models do not reflect the fact that in sAD (unlike familial AD) these genes are not risk factors per se and that other mechanisms like oxidative stress, metabolic dysregulation and inflammation play key roles in AD etiology...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27890124/clothing-related-barriers-experienced-by-people-with-mobility-disabilities-and-impairments
#13
Allison Kabel, Jessica Dimka, Kerri McBee-Black
Clothing-related issues can create barriers to social participation and other desired activities for people living with disabilities and their families. The purpose of this study was to identify clothing-related barriers people living with disabilities and their families are facing. An online survey was administered to people living with disabilities and parents/caregivers, resulting in a sample of 113 participants indicating mobility impairments. Survey results indicated that the clothing needs of people living with disabilities and impairments are not being met, the lack of appropriate clothing prevented individuals from fully engaging in social activities and relationships, employment or everyday life events...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27881105/open-trusting-relationships-underpin-safety-in-rural-maternity-a-hermeneutic-phenomenology-study
#14
Susan Crowther, Elizabeth Smythe
BACKGROUND: There are interwoven personal, professional and organisational relationships to be navigated in maternity in all regions. In rural regions relationships are integral to safe maternity care. Yet there is a paucity of research on how relationships influence safety and nurture satisfying experiences for rural maternity care providers and mothers and families in these regions. This paper draws attention to how these relationships matter. METHODS: This research is informed by hermeneutic phenomenology drawing on Heidegger and Gadamer...
November 24, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27876420/hereditary-bilateral-genu-recurvatum-case-report-of-a-family
#15
Peter Feczko, Pieter Emans
BACKGROUND: Genu recurvatum is a rare condition in children and adolescents. The origin can be osseous, ligamentous and mixed. METHODS: We describe for the first time a family inclusive two brothers and their mother with hereditary bilateral genu recurvatum of unknown etiology. The possible underlying pathology and treatment are discussed. RESULTS: The underlying pathology of the early closure of the apophysis of the tibial tuberosity remained unclear...
November 19, 2016: Knee
https://www.readbyqxmd.com/read/27868448/applying-an-ecological-framework-to-understand-transition-pathways-to-post-secondary-education-for-youth-with-physical-disabilities
#16
Sally Lindsay, Michelle Duncanson, Nadia Niles-Campbell, Carolyn McDougall, Sara Diederichs, Dolly Menna-Dack
PURPOSE: The purpose of this study was to explore the experiences of youth with physical disabilities and clinicians who support them in their transition to post-secondary education (PSE). Most research on transition to PSE has focused on youth with intellectual disabilities while there is a lack of research on youth with physical disabilities. METHODS: This study drew on 30 interviews with 20 youth with disabilities and 10 clinicians. We used Bronfrenbrenner's ecological framework to inform our analysis...
November 20, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27863039/family-member-engagement-with-early-psychosis-specialty-care
#17
Alicia Lucksted, Jennifer Stevenson, Ilana Nossel, Amy Drapalski, Sarah Piscitelli, Lisa B Dixon
BACKGROUND: Family members of individuals with early psychosis (EP) play critical roles in their engagement with EP services, but family member experiences of those roles are insufficiently understood. METHODS: We conducted semi-structured interviews with 18 family members of individuals enrolled in EP services during the Recovery After an Initial Schizophrenia Episode-Implementation Evaluation Study (RAISE-IES study), to better understand their experiences engaging with EP specialty care and their roles in client engagement in services...
November 9, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27858263/-it-was-like-walking-without-knowing-where-i-was-going-a-qualitative-study-of-autism-in-a-uk-somali-migrant-community
#18
Fiona Fox, Nura Aabe, Katrina Turner, Sabi Redwood, Dheeraj Rai
Increasing recognition of autism in Somali migrant communities means that appropriate support services are needed. Attitudes to autism and barriers related to help-seeking in these communities are poorly understood. We aimed to assess what families affected by autism need, and how health, education and social care services can support them. In partnership with the local Somali community the research team conducted 15 in-depth interviews with parents affected by autism. Two themes are reported; 'Perceptions of Autism' and 'Navigating the System'...
November 17, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27843893/evaluating-the-efficacy-of-the-support-for-life-program-for-people-with-dementia-and-their-families-and-carers-to-enable-them-to-live-well-a-protocol-for-a-cluster-stepped-wedge-randomized-controlled-trial
#19
Dianne Goeman, Tracy Comans, Joanne C Enticott, Emma Renehan, Elizabeth Beattie, Susan Kurrle, Susan Koch
INTRODUCTION: Assistance provided to support people living with dementia and carers is highly valued by them. However, current support systems in Australia are disjointed, inaccessible to all, poorly coordinated, and focus on dysfunction rather than ability. Support workers for people with dementia are in short supply, and there is little consistency in their roles. To address this large service gap and unmet need, we have developed an evidence-based optimized model of holistic support for people with dementia and their carers and families...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27830394/analysis-of-nurse-navigators-activities-for-hospital-discharge-coordination-a-mixed-method-study-for-the-case-of-cancer-patients
#20
Fatima Yatim, Paula Cristofalo, Marie Ferrua, Anne Girault, Marilene Lacaze, Mario Di Palma, Etienne Minvielle
BACKGROUND: Modern cancer care requires the development of clinical pathways to enhance coordination, but there are few descriptive studies about the content of coordination activities. More specifically, little is known about hospital discharge coordination, although this is seen as a sensitive phase of clinical pathway. PURPOSE: The purpose of this study was to identify and quantify the categories of activities performed by nurse navigators for hospital discharge coordination...
November 9, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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