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sodium hyaluronate

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https://www.readbyqxmd.com/read/28644234/efficacy-of-sodium-hyaluronate-in-murine-diabetic-ocular-surface-diseases
#1
Guohu Di, Xia Qi, Xiaowen Zhao, Songmei Zhang, Qingjun Zhou
PURPOSE: To evaluate the efficacy of sodium hyaluronate (HA) eye drops for the treatment of diabetic ocular surface diseases in mice. METHODS: Male 6- to 8-week-old C57BL/6 mice underwent induction of type 1 diabetes with intraperitoneal injections of streptozotocin, with normal mice as the control. Topical 0.3% HA, 0.1% HA, 0.4% polyethylene glycol eye drops, and normal saline were administered to diabetic mice with an intact or debrided corneal epithelium. Normal saline was applied in the controls...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28638287/use-of-sodium-hyaluronate-carboxymethylcellulose-bioresorbable-membrane-in-loop-ileostomy-construction-facilitates-stoma-closure
#2
Danielle M Bertoni, Kerry L Hammond, David E Beck, Terry C Hicks, Charles B Whitlow, H David Vargas, David A Margolin
BACKGROUND: Loop ileostomy is a common adjunct to surgical procedures for low rectal cancers and inflammatory bowel disease. Ileostomy closure through a limited incision can be technically challenging. We hypothesized that placing a sodium hyaluronate/carboxymethylcellulose (SH/CMC) bioresorbable membrane at loop ileostomy creation would decrease stoma closure time without increasing morbidity. METHODS: In a retrospective review at a single institution with 6 board-certified colorectal surgeons, patients with loop ileostomy creation and closure between September 1999 and December 2011 were grouped based on SH/CMC placement at ileostomy creation...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28622807/the-comparison-of-the-effects-of-a-novel-hydrogel-compound-and-traditional-hyaluronate-following-micro-fracture-procedure-in-a-rat-full-thickness-chondral-defect-model
#3
Yunus Emre Akman, Erhan Sukur, Ahmet Senel, Nur Ece Oztas Sukur, Canan Kelten Talu, Yusuf Ozturkmen
PURPOSE: The aim of this experimental study was to investigate the impact of HA-CS-NAG compound (hyaluronate, sodium chondroitin sulfate, N-acetyl-d-glucosamine) on the quality of repair tissue after micro-fracture and to compare it with HA (hyaluronat), in a rat full-thickness chondral defect model. METHODS: Full-thickness chondral defects were created in a non-weight bearing area by using a handle 2.7-mm drill bit, in the right knees of 33 Sprague-Dawley rats...
June 13, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28619641/optimal-conditions-for-producing-bactericidal-sodium-hyaluronate-tio2-bionanocomposite-and-its-characterization
#4
Mohsen Safaei, Mojtaba Taran
In this research, the creation of optimum conditions for the formation of sodium hyaluronate-TiO2 bionanocomposite and its antibacterial effect on gram positive and gram negative bacteria was evaluated. The Fourier transform infrared spectroscopy spectra, scanning electron microscopy images and energy dispersive X-ray spectroscopy pattern confirmed the formation of the bionanocomposite. Thermogravimetric analysis and differential thermal analysis indicated that the thermal stability rate had significantly improved with formation of the bionanocomposite...
June 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28618979/complications-and-post-operative-sequelae-of-temporomandibular-joint-arthrocentesis
#5
Luigi Angelo Vaira, Maria Teresa Raho, Damiano Soma, Giovanni Salzano, Giovanni Dell'aversana Orabona, Pasquale Piombino, Giacomo De Riu
OBJECTIVE:  To evaluate intraoperative complications and postsurgical sequelae associated with arthrocentesis of the TMJ, including injection of Sodium Hyaluronate. METHODS: This retrospective study evaluated 433 arthrocentesis procedures performed in 315 patients between January 2009 and August 2016. The authors reviewed the complications identified during the procedure and the follow-up period. RESULTS: Temporary swelling of the periarticular tissues (95...
June 15, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28606267/-comparison-of-two-kinds-of-artificial-tears-on-the-dry-eye-after-phacoemulsification
#6
R You, J Wang, Y Han, L J Liu, W Y Wang
Objective: To compare the curative effect of two different artificial tears on dry eye after phacoemulsification. Methods: Prospective randomized controlled clinical trial. From March to June in 2012, 102 patients (102 eyes) with age-related cataract were treated with phacoemulsification at Beijing Tongren Hospital, Capital University of Medical Sciences, and these eyes were randomly divided into blank group (group A ) 32 cases, treatment group 1 (group B) 35 cases and treatment group 2 (group C) 35 cases. Group A was treated with conventional antibiotics...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28599475/therapeutic-results-of-a-novel-enzyme-targeting-radiosensitization-treatment-kochi-oxydol-radiation-therapy-for-unresectable-carcinomas-ii-in-patients-with-stage-i-primary-breast-cancer
#7
Nobutaka Aoyama, Yasuhiro Ogawa, Miki Yasuoka, Kenta Ohgi, Hitomi Iwasa, Kana Miyatake, Rika Yoshimatsu, Tomoaki Yamanishi, Norihiko Hamada, Taiji Tamura, Kana Kobayashi, Yoriko Murata, Mitsuhiko Miyamura, Takuji Yamagami
Linac-based stereotactic radiotherapy has little effect on the majority of advanced neoplasms. Therefore, the novel radiosensitizer Kochi oxydol-radiation therapy for unresectable carcinomas (KORTUC) II, which contains hydrogen peroxide and sodium hyaluronate, was developed. The effectiveness of KORTUC II for the treatment of chemotherapy-resistant supraclavicular lymph node metastases, recurrent breast cancer and stage IV primary breast cancer has previously been demonstrated. The present study evaluated the safety and efficacy of KORTUC II for patients with stage I primary breast cancer...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28581895/safety-and-efficacy-of-alginate-adhesion-barrier-gel-in-compromised-intestinal-anastomosis
#8
Ankit A Chaturvedi, Simon T K Yauw, Roger M L M Lomme, Thijs Hendriks, Harry van Goor
BACKGROUND: For any anti-adhesive barrier developed for abdominal surgery, the use under conditions in which anastomotic healing is compromised needs to be investigated. The current study evaluates the effect of a new ultrapure alginate gel on early healing of high-risk anastomoses in the ileum and compares this with the gold standard used in clinical practice. MATERIALS AND METHODS: In 75 adult male Wistar rats, a 5 mm ileal segment was resected and continuity was restored by construction of an inverted anastomosis...
June 5, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28577961/histologic-evaluation-of-regenerative-endodontic-procedures-with-the-use-of-chitosan-scaffolds-in-immature-dog-teeth-with-apical-periodontitis
#9
Paulo J Palma, João C Ramos, João B Martins, Anibal Diogenes, Maria H Figueiredo, Paula Ferreira, Carlos Viegas, João M Santos
INTRODUCTION: The aim of this study was to evaluate histologically the newly formed tissues after regenerative endodontic procedures (REPs) in dogs using either a blood clot (BC) or 2 different formulations of a chitosan hydrogel as scaffolds. METHODS: Apical periodontitis was induced by inoculating immature teeth with oral plaque in 4 beagle dogs. Teeth (n = 96) were divided into 2 control (n = 20) and 4 test groups (n = 76) according to the treatment: apexification and REPs with BC, sodium hyaluronate:chitosan (HA:CS) scaffolds, or pectin:chitosan (P:CS) scaffolds...
May 31, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28551811/enzymatic-properties-of-alginate-lyase-from-paenibacillus-sp-s29
#10
Masahiro Kurakake, Yuhei Kitagawa, Atsushi Okazaki, Kazuyuki Shimizu
Paenibacillus sp. S29 was isolated from soil and produces an alginate lyase. The molecular weight of this enzyme was 32 kDa and the N-terminal amino acid sequence was ASVTKST. The optimal pH was approximately 8.7 and the enzyme was stable over a pH range of 5.6 to 8.8 at 40 °C for 60 min. The optimal temperature was approximately 50 °C, and the residual activity was not decreased at temperatures of up to 40 °C at pH 8 for 30 min. Paenibacillus sp. S29 alginate lyase had also a little activity toward hyaluronic acid...
May 27, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28549436/efficacy-and-safety-of-single-injection-of-cross-linked-sodium-hyaluronate-vs-three-injections-of-high-molecular-weight-sodium-hyaluronate-for-osteoarthritis-of-the-knee-a-double-blind-randomized-multi-center-non-inferiority-study
#11
Chul-Won Ha, Yong-Beom Park, Chong-Hyuk Choi, Hee-Soo Kyung, Ju-Hong Lee, Jae Doo Yoo, Ju-Hyung Yoo, Choong-Hyeok Choi, Chang-Wan Kim, Hee-Chun Kim, Kwang-Jun Oh, Seong-Il Bin, Myung Chul Lee
BACKGROUND: This randomized, double-blind, multi-center, non-inferiority trial was conducted to assess the efficacy and safety of a cross-linked hyaluronate (XLHA, single injection form) compared with a linear high molecular hyaluronate (HMWHA, thrice injection form) in patients with symptomatic knee osteoarthritis. METHODS: Two hundred eighty seven patients with osteoarthritis (Kellgren-Lawrence grade I to III) were randomized to each group. Three weekly injections were given in both groups but two times of saline injections preceded XLHA injection to maintain double-blindness...
May 26, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28546691/toxic-anterior-segment-syndrome-outbreak-after-cataract-surgery-triggered-by-viscoelastic-substance
#12
AyşeGül Koçak Altıntaş, Meryem Yaşar Ciritoğlu, Özlem BeyazyıldıZ, Çiğdem Ülkü Can, Sibel Polat
PURPOSE: The purpose of this study is to present toxic anterior segment syndrome (TASS) outbreak at our clinic and discuss possible causes of TASS. MATERIALS AND METHODS: Thirty-four eyes of 34 patients developed TASS in a consecutive 2 weeks period were included in this study. Both anterior segment and fundus examinations were performed before and after uncomplicated cataract surgery. During the follow-up period, clinical features and all possible causes were evaluated including perioperative products and processing such as sterilization technique of surgical instruments, irrigating solutions, drugs, viscoelastic substance (VES), and intraocular lens...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28535076/intraarticular-injection-of-a-cross-linked-sodium-hyaluronate-combined-with-triamcinolone-hexacetonide-cingal-to-provide-symptomatic-relief-of-osteoarthritis-of-the-knee-a-randomized-double-blind-placebo-controlled-multicenter-clinical-trial
#13
Laszlo Hangody, Robert Szody, Piotr Lukasik, Wojciech Zgadzaj, Endre Lénárt, Eva Dokoupilova, Daniela Bichovsk, Agnes Berta, Gabor Vasarhelyi, Andrea Ficzere, György Hangody, Gary Stevens, Miklos Szendroi
OBJECTIVE: To evaluate the efficacy and safety of an intraarticular injection of Cingal (Anika Therapeutics, Inc., Bedford, MA) compared with Monovisc (Anika Therapeutics, Inc., Bedford, MA) or saline for the treatment of knee osteoarthritis. DESIGN: This multicenter, double-blind, saline-controlled clinical trial randomized subjects with knee osteoarthritis (Kellgren-Lawrence grades I-III) to a single injection of Cingal (4 mL, 88 mg hyaluronic acid [HA] plus 18 mg triamcinolone hexacetonide [TH]), Monovisc (4 mL, 88 mg HA), or saline (4 mL, 0...
May 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28524142/-effectiveness-of-epithelialization-therapy-after-surgical-treatment-of-pterygiu
#14
A V Petraevskiy, K S Trishkin, I A Gndoyan
Pterygium is widely distributed in regions with hot and dry climate. Frequent relapses of the disease are due to delayed epithelialization of postoperative corneal erosion, associated inflammation and formation of dry areas of the cornea. Effective stimulation of corneal epithelium regeneration in the postoperative period could reduce the frequency of relapses. AIM: to compare the effectiveness, safety and tolerability of different keratoprotectors in patients after surgical treatment of pterygium...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28521984/rheological-properties-of-gels-formed-by-physical-interactions-between-hyaluronan-and-cationic-surfactants
#15
Tereza Venerová, Miloslav Pekař
The aim of this paper is the rheological characterization of the concentrated, gel-like phase, which arises from mixed solutions of sodium hyaluronate and oppositely charged surfactant above its critical micellar concentration. The effects of hyaluronan molecular weight (from 300 to 2kDa) and the concentration of initial solutions (0.5 and 2% for hyaluronan, 50 or 200mM for surfactant) were investigated. All systems demonstrated viscoelastic properties which can be modified over a broad range of several decades of both storage and loss moduli by the hyaluronan molecular weight and initial concentrations...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28506871/the-role-of-hyaluronan-as-a-drug-carrier-to-enhance-the-bioavailability-of-extended-release-ophthalmic-formulations-hyaluronan-timolol-ionic-complexes-as-a-model-case
#16
F D Battistini, L I Tártara, C Boiero, M L Guzmán, L C Luciani-Giaccobbe, S D Palma, D A Allemandi, R H Manzo, M E Olivera
The aim of this work was to obtain information concerning the properties of ophthalmic formulations based on hyaluronic-drug ionic complexes, to identify the factors that determine the onset, intensity and duration of the pharmacotherapeutic effect. Dispersions of a complex of 0.5% w/v of sodium hyaluronate (HyNa) loaded with 0.5% w/v of timolol maleate (TM) were obtained and presented a counterionic condensation higher than 75%. For comparison a similar complex obtained with hyaluronic acid (HyH) was also prepared...
May 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28504157/biomacromolecular-based-ionic-covalent-hydrogels-for-cell-encapsulation-the-atelocollagen-oxidized-polysaccharides-couples
#17
Andreea Luca, Vasilica Maier, Stelian S Maier, Maria Butnaru, Maricel Danu, Constanta Ibanescu, Mariana Pinteala, Marcel Popa
Mixed crosslinked networks of ionic-covalent entanglement type were prepared starting from ternary mixtures of atelocollagen (aK; as fibrillary matrix generator), sodium hyaluronate (NaHyal; a microfibrillation assistant), and oxidized polysaccharides (OxPolys; as both cross-linkers and matrix fillers), and were tested as hydrogels for eukaryotic cell encapsulation. Either oxidized gellan (GellOx) or pullulan (PullOx) were used. An original procedure and optimal hydrogel recipes were developed to encapsulate fibroblasts and adipose-derived stem cells, while preserving their viability and proliferative ability during ex vivo temporarily storage...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28504144/low-molecular-weight-xanthan-gum-suppresses-oxidative-stress-induced-apoptosis-in-rabbit-chondrocytes
#18
Qixin Chen, Xintian Shao, Peixue Ling, Fei Liu, Huarong Shao, Aibin Ma, Jixu Wu, Wei Zhang, Fuyan Liu, Guanying Han, Fengshan Wang
We have previously reported the application of low molecular weight XG(LM-XG), with molecular weights ranging from 1×10(6)Da to 1.5×10(6)Da for treating osteoarthritis. In this study, we investigated the anti-apoptotic activity of LM-XG under oxidative stress conditions, activated by hydrogen peroxide (H2O2)-treated chondrocytes in vitro. Chondrocytes were pretreated with various doses of LM-XG (0, 10, 100, 500, or 1000μg/mL) or 1000μg/mL sodium hyaluronate for 12h, and then exposed to 0.5mmol/L H2O2 for another 12h...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28503072/long-term-clinical-benefit-and-cost-effectiveness-of-an-8-week-multimodal-knee-osteoarthritis-management-program-incorporating-intra-articular-sodium-hyaluronate-hyalgan-%C3%A2-injections
#19
Larry E Miller, Michael J Sloniewsky, Thomas E Gibbons, Janice G Johnston, Kent D Vosler, Saad Nasir
BACKGROUND: Given the poor long-term effectiveness of focused nonsurgical knee osteoarthritis (OA) treatments, alternative therapies are needed for patients who have unsuccessfully exhausted nonsurgical options. METHODS: A telephone interview was conducted in patients who participated in a single 8-week multimodal knee OA treatment program (mean follow-up: 3.7 years, range: 2.7-4.9 years). The program consisted of five intra-articular knee injections of sodium hyaluronate (Hyalgan(®)), with each injection given 1 week apart, structured physical therapy, knee bracing, and patient education...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28497070/impact-of-polyethylene-glycol-400-propylene-glycol-hydroxypropyl-guar-and-0-1-sodium-hyaluronate-on-postoperative-discomfort-following-cataract-extraction-surgery-a-comparative-study
#20
Georgios Labiris, Panagiota Ntonti, Haris Sideroudi, Vassilios Kozobolis
BACKGROUND: Universal postoperative guidelines for cataract extraction surgery are yet to be introduced. Artificial tears are gaining popularity as an additional integral component of the postoperative regime. The primary objective of this study was to explore the impact of two prevalent artificial tear preparations on postoperative discomfort following cataract extraction surgery. METHODS: A total of 180 patients that underwent cataract extraction surgery were randomly divided into three groups according to their postoperative regime: a) Study group 1 (SG1) received a fixed combination of tobramycin and dexamethasone (FCTD) quid for 3 weeks and, additionally polyethylene glycol 400/propylene glycol/hydroxypropyl-guar quid, for 6 weeks, b) Study group 2 (SG2) received FCTD quid for 3 weeks and, additionally 0...
2017: Eye and Vision (London, England)
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