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sodium hyaluronate

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https://www.readbyqxmd.com/read/29139103/differentiation-potential-of-human-adipose-stem-cells-bioprinted-with-hyaluronic-acid-gelatin-based-bioink-through-microextrusion-and-visible-light-initiated-crosslinking
#1
Shinji Sakai, Hiromi Ohi, Tomoki Hotta, Hidenori Kamei, Masahito Taya
Bioprinting has a great potential to fabricate three-dimensional (3D) functional tissues and organs. In particular, the technique enables fabrication of 3D constructs containing stem cells while maintaining cell proliferation and differentiation abilities, which is believed to be promising in the fields of tissue engineering and regenerative medicine. We aimed to demonstrate the utility of the bioprinting technique to create hydrogel constructs consisting of hyaluronic acid (HA) and gelatin derivatives through irradiation by visible light to fabricate 3D constructs containing human adipose stem cells (hADSCs)...
November 15, 2017: Biopolymers
https://www.readbyqxmd.com/read/29138694/impact-of-topically-administered-steroids-antibiotics-and-sodium-hyaluronate-on-bleb-related-infection-onset-the-japan-glaucoma-society-survey-of-bleb-related-infection-report-4
#2
Hideto Sagara, Tetsuya Yamamoto, Kimihiro Imaizumi, Tetsuju Sekiryu
Purpose: To investigate the impact of topically administered ophthalmic medications on the onset and severity of bleb-related infections. Methods: Data obtained from 104 eyes of 104 patients with bleb-related infections were analyzed. We assigned an infection stage to each eye (stage 1-4) and analyzed the onset severity. Results: Steroids and antibiotics were routinely administered to 13 (12.5%) and 42 (40.4%) eyes, respectively. The median stage of steroid-administered eyes was 3 versus 1 for eyes without steroid administration (P = 0...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29110601/drug-release-from-porous-matrixes-based-on-natural-polymers
#3
B Kaczmarek, A Sionkowska
BACKGROUND: This review provides a report on recent advances in the field of drug release from matrixes made of natural polymers. Such matrixes have attracted not only academic but also practical attention in the case of several biopolymers since these can be used for biomedical purposes due to their interesting properties. Herein, the properties of natural polymers such as proteins and polysaccharides are discussed in general. Selected detailed examples of drug release profiles from biopolymer matrixes have also been collected from scientific literature and practical work, and commented on...
November 3, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29108480/short-term-homing-of-hyaluronan-primed-cells-therapeutic-implications-for-osteoarthritis-treatment
#4
Giovanna Desando, Isabella Bartolotti, Carola Cavallo, Antonella Schiavinato, Cynthia Secchieri, Elizaveta Kon, Giuseppe Filardo, Maurizio Paro, Brunella Grigolo
The evaluation of key factors modulating cell homing following transplantation can provide new insights in the comprehension of unsolved biological questions about the use of cell therapies for osteoarthritis (OA). The main purpose of this in vivo study was to investigate the biodistribution of an intra-articular (IA) injection of mesenchymal stromal cells (MSCs) and bone marrow concentrate (BMC) in a rabbit OA model, and whether the additional use of sodium hyaluronate (HA) could modulate their migration and promote joint repair...
November 6, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29103324/collagen-based-porous-scaffolds-containing-plga-microspheres-for-controlled-kartogenin-release-in-cartilage-tissue-engineering
#5
Xiaomin Sun, Jianhua Wang, Yingying Wang, Qiqing Zhang
A scaffold composed of different collagen (COL)/chitosan (CS)/hyaluronic acid sodium (HAS) salt ratios was evaluated by determining porosity, swelling, loss rate in hot water, mechanical property, and cell proliferation to obtain optimum conditions for manufacturing porous scaffolds. Results showed that the optimal ratio of COL/CS/HAS salt porous scaffold was 1:1:0.1. High swelling and loss rate of scaffolds/microspheres (MPs) could lead to high diffusion rate of MPs from the scaffolds, causing an increase in the kartogenin (KGN) release...
November 6, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29077152/pathological-and-cytological-changes-of-the-nasal-mucosa-in-acute-rhinosinusitis-the-role-of-hyaluronic-acid-as-supportive-therapy
#6
A Ciofalo, G Zambetti, G Altissimi, M Fusconi, P Soldo, M Gelardi, G Iannella, B Pasquariello, G Magliulo
OBJECTIVE: The aim of this study was to evaluate the reparative role of hyaluronic acid in acute rhinosinusitis (ARS). PATIENTS AND METHODS: 48 patients affected by ARS were submitted to nasal endoscopy, nasal cytology, mucociliary transport evaluation (MCTt) and visual analogue scale questionnaire (VAS) at T0, after 14-18 days (T1) and after 30-35 days (T2). The patients were randomized into two groups, A and B, and received Levofloxacin and Prednisone. Moreover, using a nebulizer ampoule for nasal douche, Group A received high molecular weight Sodium Hyaluronate (3%) plus saline solution (NaCl 0...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29053076/protective-effect-of-biodegradable-nerve-conduit-against-peripheral-nerve-adhesion-after-neurolysis
#7
Kosuke Shintani, Takuya Uemura, Kiyohito Takamatsu, Takuya Yokoi, Ema Onode, Mitsuhiro Okada, Hiroaki Nakamura
OBJECTIVE Peripheral nerve adhesion caused by extraneural and intraneural scar formation after neurolysis leads to nerve dysfunction. The authors previously developed a novel very flexible biodegradable nerve conduit composed of poly(L-lactide) and poly(ε-caprolactone) for use in peripheral nerve regeneration. In the present study, they investigated the effect of protective nerve wrapping on preventing adhesion in a rat sciatic nerve adhesion model. METHODS Rat sciatic nerves were randomly assigned to one of the following four groups: a no-adhesion group, which involved neurolysis alone without an adhesion procedure; an adhesion group, in which the adhesion procedure was performed after neurolysis, but no treatment was subsequently administered; a nerve wrap group, in which the adhesion procedure was performed after neurolysis and protective nerve wrapping was then performed with the nerve conduit; and a hyaluronic acid (HA) group, in which the adhesion procedure was performed after neurolysis and nerve wrapping was then performed with a 1% sodium HA viscous solution...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29038631/efficacy-of-temporomandibular-joint-arthrocentesis-with-sodium-hyaluronate-in-the-management-of-temporomandibular-joint-disorders-a-prospective-randomized-control-trial
#8
Harsha Gorrela, J Prameela, G Srinivas, B Vijay Baskar Reddy, Mvs Sudhir, Gururaj Arakeri
PURPOSE: This study was designed to investigate the efficacy of the temporomandibular joint arthrocentesis with and without injection of sodium hyaluronate (SH) in the treatment of temporomandibular joint disorders. PATIENTS AND METHODS: A total of sixty two TMJs in 34 males and 28 females aged 20-65 years comprised the study material. The patients' complaints were limited mouth opening, TMJ pain, and joint noises during function. Patients were randomly divided into 2 groups in which arthrocentesis plus intra-articular injection of sodium hyaluronate was performed in 1 group and only arthrocentesis was performed in the other group...
December 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29038066/in-vitro-and-preclinical-assessment-of-an-intranasal-spray-formulation-of-parathyroid-hormone-pth-1-34-for-the-treatment-of-osteoporosis
#9
Allan J Williams, Faron Jordan, Gareth King, Andrew L Lewis, Lisbeth Illum, Tahir Masud, Alan C Perkins, Richard G Pearson
Osteoporosis treatment with PTH 1-34 injections significantly reduces the incidence of bone fracture. Potential further reductions in fracture rate should be observed through nasal spray delivery to address the poor compliance associated with patient dislike of repeated PTH 1-34 subcutaneous injections. In vitro human osteoblast-like Saos-2 cell intracellular cAMP levels were used to define PTH 1-34 nasal spray formulation bioactivity. The chemically synthesised PTH 1-34 had an EC50 of 0.76nM. Absorption enhancers polyethylene glycol (15)-hydroxystearate (Solutol(®) HS15), poloxamer 407, chitosan or sodium hyaluronate did not diminish the bioactivity of PTH 1-34 within an in vitro cell culture model (p >0...
October 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29036920/evaluation-of-mc3t3-cells-proliferation-and-drug-release-study-from-sodium-hyaluronate-1-4-butanediol-diglycidyl-ether-patterned-gel
#10
Sumi Bang, Dipankar Das, Jiyun Yu, Insup Noh
A pattern gel has been fabricated using sodium hyaluronate (HA) and 1,4-butanediol diglycidyl ether (BDDGE) through the micro-molding technique. The cellular behavior of osteoblast cells (MC3T3) in the presence and absence of dimethyloxalylglycine (DMOG) and sodium borate (NaB) in the pattern gel (HA-BDDGE) has been evaluated for its potential application in bone regeneration. The Fourier transform infrared spectroscopy (FTIR), (13)C-nuclear magnetic resonance spectroscopy ((13)C NMR), and thermogravimetric analysis (TGA) results implied the crosslinking reaction between HA and BDDGE...
October 14, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28993846/-hyaluronan-as-a%C3%A2-key-for-accelerated-wound-healing-in-human-3d-full-thickness-skin-models
#11
L Rüther, L Bolke, G R Schlippe, W A Voss
BACKGROUND: Wound healing can be divided into three phases: (1) exsudation phase, (2) granulation phase, (3) regeneration phase. In particular, the epithelization phase is of great importance in order to quickly reconstitute the natural skin barrier. The aim of the present study was to determine the reepithelization kinetics of untreated and 0.5% sodium hyaluronate (NHA) treated human 3D full thickness skin models. MATERIALS AND METHODS: The test protocol consisted of topically applying 10 µl of the test substance 0...
October 9, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28962787/novel-apigenin-loaded-sodium-hyaluronate-nano-assemblies-for-targeting-tumor-cells
#12
Ting Zhao, Yue He, Huali Chen, Yan Bai, Wenjing Hu, Liangke Zhang
We aimed to construct a novel nano-assembly carrying apigenin (APG), a hydrophobic drug, and to evaluate its in vitro targeting ability for A549 cells overexpressing CD44 receptors. The apigenin-loaded sodium hyaluronate nano-assemblies (APG/SH-NAs) were assembled by multiple non-covalent interactions between sodium hyaluronate (SH) and APG. The prepared APG/SH-NAs exhibited a small average size and narrow particle size distribution. In addition, satisfactory encapsulation efficiency and drug loading were obtained...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28937526/comparison-of-corneal-wetting-properties-of-different-dispersive-ophthalmic-viscosurgical-devices-an-optical-coherence-tomography-study
#13
Cagatay Karaca, Mustafa Ozkose, Metin Unlu, Duygu Gulmez Sevim, Ertugrul Mirza
PURPOSE: To compare corneal wetting performances of different dispersive ophthalmic viscosurgical devices. METHODS: Three different types of dispersive ophthalmic viscosurgical devices, hydroxypropyl methylcellulose %2 (HPMC), sodium hyaluronate %3-sodium chondroitin sulphate %4 (HACS), and sodium hyaluronate %3 (HA), were applied on corneal surfaces of 10 healthy volunteer subjects repeatedly at 3 different time points. Corneal wetting properties of the ophthalmic viscosurgical devices were compared qualitatively and quantitatively by anterior segment optical coherence tomography for 30 minutes...
September 20, 2017: Retina
https://www.readbyqxmd.com/read/28927491/effectiveness-of-intranasal-sodium-hyaluronate-in-mitigating-adverse-effects-of-nasal-continuous-positive-airway-pressure-therapy
#14
(no author information available yet)
BACKGROUND: Nasal continuous positive airway pressure (CPAP) in moderate-to-severe cases of obstructive sleep apnea cancause nasal discomfort and other undesirable problems. OBJECTIVE: The aim of our study was to test the effects of sodium hyaluronate on nasal problems that patients experienced in their daily lives, sleepiness, nasal resistance to airflow, nasal mucociliary clearance, changes in inflammatory markers, and compliance to CPAP in three groups of patients with obstructive sleep apnea syndrome on CPAP therapy...
September 19, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28924123/the-improvement-of-the-hepatic-histological-findings-in-a-patient-with-non-alcoholic-steatohepatitis-with-type-2-diabetes-after-the-administration-of-the-sodium-glucose-cotransporter-2-inhibitor-ipragliflozin
#15
Akihiko Takeda, Aya Irahara, Atsuko Nakano, Emi Takata, Yuko Koketsu, Kunie Kimata, Eri Senda, Hajime Yamada, Kazuhito Ichikawa, Takahiro Fujimori, Yoshio Sumida
The patient was a 67-year-old woman with type 2 diabetes and non-alcoholic steatohepatitis (NASH). The administration of the sodium-glucose cotransporter 2 (SGLT2) inhibitor, ipragliflozin improved her liver dysfunction clinically and histologically. The serum alanine aminotransferase (ALT) and ferritin levels decreased to normal limits after treatment for four months. Type IV collagen and hyaluronic acid, both of which were serum fibrotic markers, decreased after treatment. Ultrasonography and computed tomography showed a decrease in the fat deposits in her liver...
October 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28904301/a-case-of-gastric-lipoma-resected-by-endoscopic-submucosa-dissection-with-difficulty-in-preoperative-diagnosis
#16
Mizue Ichinose, Takuto Hikichi, Yukiko Kanno, Naohiko Gunji, Masashi Fujita, Masahito Kuroda, Kumiko Terashima, Yoshinori Sato, Satoshi Kawana, Yuko Hashimoto, Hiromasa Ohira, Masayuki Miyata
A 66-year-old man was referred to our hospital with an increasing subepithelial lesion in the gastric antrum. Using esophagogastroduodenoscopy, a tumor with a steep, 20-mm-high rise protruding in the lumen was observed. The mucosal surface of the tumor was reddish, with ulcers forming at the base. Moreover, the tumor was mobile and soft. A biopsy specimen was taken from the ulcer, but tumor tissue was not collected from the submucosa. Endoscopic ultrasonography (EUS) showed a high echoic mass in the submucosa...
September 14, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28902938/evaluation-of-the-effectiveness-of-sodium-hyaluronate-sesame-oil-honey-and-silver-nanoparticles-in-preventing-postoperative-surgical-adhesion-formation-an-experimental-study
#17
COMPARATIVE STUDY
Hamid Reza Khorshidi, Amir Kasraianfard, Amir Derakhshanfar, Siavash Rahimi, Ali Sharifi, Hamid Reza Makarchian, Manoochehr Ghorbanpoor, Seyed Mohammad Reza Javadi
Purpose: To evaluate the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing of postoperative surgical adhesion formation. Methods: Forty male Wistar rats were randomly assigned into five groups with eight rats in each group including control, hyaluronate, sesame, honey and silver groups. After two weeks the animals underwent laparotomy and were evaluated by two different blinded surgeons for severity of adhesions based on the two different classification scoring systems including Nair classification and cumulative adhesion scoring scale...
August 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28887954/fabrication-self-assembly-and-biomedical-applications-of-luminescent-sodium-hyaluronate-with-aggregation-induced-emission-feature
#18
Dan Wei, Yun Xue, Hongye Huang, Meiying Liu, Guangjian Zeng, Qing Wan, Liangji Liu, Jun Yu, Xiaoyong Zhang, Yen Wei
Organic dyes with aggregation-induced emission (AIE) feature have recently attracted much research attention for biomedical applications due to their inimitable optical superiority. Although many reports have demonstrated for fabricating AIE-active nanoprobes, the synthesis of AIE-active natural polymers is still very limited. In this work, fluorescent organic nanoparticles (FONs) with AIE feature have been prepared through formation of Schiff base interaction between amino-terminated AIE dye (PhE) and oxidation sodium hyaluronate (OSH)...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28881287/recent-advances-in-polysaccharides-for-osteoarthritis-therapy
#19
REVIEW
Qixin Chen, Xintian Shao, Peixue Ling, Fei Liu, Guanying Han, Fengshan Wang
The polysaccharides used in the treatment of osteoarthritis (OA) mainly include sodium hyaluronate, chondroitin sulfate, chitosan, xanthan gum, Low molecular weight heparin, alginate and other polysaccharides. This review summarizes the recent advances in the chemistry and biological activities of polysaccharides for the treatment of OA.
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28839449/comparison-of-the-3-different-injection-techniques-used-in-a-randomized-controlled-study-evaluating-a-cross-linked-sodium-hyaluronate-combined-with-triamcinolone-hexacetonide-cingal-for-osteoarthritis-of-the-knee-a-subgroup-analysis
#20
Robert McCormack, Martin Lamontagne, Christopher Vannabouathong, Robert T Deakon, Etienne L Belzile
A recent trial demonstrated that patients with knee osteoarthritis treated with a sodium hyaluronate and corticosteroid combination (Cingal) experienced greater pain reductions compared with those treated with sodium hyaluronate alone (Monovisc) or saline up to 3 weeks postinjection. In this study, injections were administered by 1 of 3 approaches; however, there is currently no consensus on which, if any, of these techniques produce a more favorable outcome. To provide additional insight on this topic, the results of the previous trial were reanalyzed to determine whether (1) the effect of Cingal was significant within each injection technique and (2) pain reductions were similar between injection techniques across all treatment groups...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
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