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https://www.readbyqxmd.com/read/27909627/recurrence-of-childhood-nephrogenic-adenoma-in-urinary-bladder-developed-four-years-after-previous-surgery-despite-intravesical-sodium-hyaluronate-therapy
#1
Burak Özçift, Ayper Kaçar, Hüseyin Tuğrul Tiryaki
Nephrogenic adenoma (NA) is a rarely seen benign metaplastic lesion of the urinary tract. Its etiology is uncertain, but induced by chronic inflammation, irritation, and trauma. NA is located in the urinary tract, most commonly in the bladder. NA usually presents with hematuria and lower urinary tract symptoms. In the literature it is mostly seen in adults but about 30 cases of NA's have been reported in children. Treatment of intravesical lesions consists of transurethral resection (TUR) and fulguration and rarely partial or total cystectomy may be required in ineffective TUR...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27854436/the-influence-of-hyaluronan-addition-on-thickness-weight-uniformity-of-mass-and-water-content-of-mucoadhesive-films
#2
Veronika Walicová, Jan Gajdziok, Markéta Gajdošová, David Vetchý
Characteristics of the buccal mucoadhesive films (film thickness, film weight, uniformity of mass and moisture content) prepared by solvent casting method were tested in this experimental study. The formulations consisted either of one mucoadhesive polymer (sodium hyaluronate of two different molecular weights and sodium carboxymethylcellulose) or combinations thereof. On the basis of the aforementioned tests, it was determined that water content was influenced by the molecular weight of sodium hyaluronate as well as by the ratio of mucoadhesive polymers in the composition...
2016: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/27822014/hyaluronic-acid-and-oxidized-regenerated-cellulose-prevent-adhesion-reformation-after-adhesiolysis-in-rat-models
#3
Yan Zhang, Qin Liu, Ning Yang, Xuegang Zhang
Postsurgical adhesion formation is the most common complication in abdominal and pelvic surgery. Adhesiolysis is the most commonly applied treatment for adhesion formation but is often followed by adhesion reformation. Therefore, an efficient strategy should be adopted to solve these problems. This study aimed to explore whether hyaluronic acid and oxidized regenerated cellulose (ORC) could prevent adhesion formation and reformation. Thirty female Sprague Dawley rats were randomly divided into three groups (n=10 each) and subjected to different treatments during the first and second surgery...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27793685/transcutaneous-immunization-via-rapidly-dissolvable-microneedles-protects-against-hand-foot-and-mouth-disease-caused-by-enterovirus-71
#4
Zhuangzhi Zhu, Xiaohua Ye, Zhiqiang Ku, Qingwei Liu, Chaoyun Shen, Huafei Luo, Hansen Luan, Chenghao Zhang, Shaoqiong Tian, CheeYen Lim, Zhong Huang, Hao Wang
Recent large outbreaks of hand-foot-and-mouth disease (HFMD) have seriously affected the health of young children. Enterovirus 71 (EV71) is the main causative agent of HFMD. Herein, for the first time, rapidly dissolvable microneedles (MNs) loaded with EV71 virus-like particles (VLPs) were evaluated whether they could induce robust immune responses that confer protection against EV71 infection. The characteristics of prepared MNs including hygroscopy, mechanical strength, insertion capacity, dissolution profile, skin irritation and storage stability were comprehensively assessed...
October 25, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27771488/preformulation-of-cysteamine-gels-for-treatment-of-the-ophthalmic-complications-in-cystinosis
#5
Barbara McKenzie, Graeme Kay, Kerr H Matthews, Rachel Knott, Donald Cairns
Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all organs. It is treated by regular administration of the aminothiol, cysteamine. Corneal crystal deposition is one of the most troublesome complications affecting patients and requires the hourly administration of cysteamine eye drops. In an attempt to reduce this frequency and improve the treatment, the preformulation and evaluation of cysteamine containing gels is reported. Suitability for ophthalmic delivery was determined by analysis of rheology, bioadhesion, dissolution and stability...
December 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27769383/rapid-detection-of-bacterial-endotoxins-in-ophthalmic-viscosurgical-device-materials-by-direct-analysis-in-real-time-mass-spectrometry
#6
Hongli Li, Victoria M Hitchins, Samanthi Wickramasekara
Bacterial endotoxins are lipopolysaccharides bound to the bacterial cell wall and released when bacteria rupture or disintegrate. Possible contamination of endotoxin in ophthalmic devices can cause a painful eye inflammation or result in toxic anterior segment syndrome after cataract surgery. Measurement of bacterial endotoxin in medical device materials is difficult since endotoxin binds with polymer matrix and some of the materials are very viscous and non-water soluble, where traditional enzyme-based Limulus amebocyte lysate (LAL) assay cannot be applied...
November 2, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27753246/prospective-randomized-controlled-study-on-the-validity-and-safety-of-an-absorbable-adhesion-barrier-interceed%C3%A2-made-of-oxidized-regenerated-cellulose-for-laparoscopic-colorectal-surgery
#7
Masanori Naito, Naoto Ogura, Takahiro Yamanashi, Takeo Sato, Takatoshi Nakamura, Hirohisa Miura, Atsuko Tsutsui, Yasutoshi Sakamoto, Rieko Tanaka, Yuji Kumagai, Masahiko Watanabe
INTRODUCTION: Clinical use of an adhesion barrier made of oxidized, regenerated cellulose, Interceed®, has been reported in the field of obstetrics and gynecology to help prevent adhesions between the peritoneum and the bowel in various types of operations. In gastrointestinal surgery, sodium hyaluronate/carboxymethylcellulose has been reported as an absorbable membrane to reduce postoperative adhesions. The present study was a prospective randomized controlled study to investigate the safety and usefulness of Interceed in laparoscopic colorectal surgery...
October 18, 2016: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/27714459/sodium-hyaluronate-an-effective-adjunct-in-temporomandibular-joint-arthrocentesis
#8
Poornima Patel, Faisal Idrees, Vilas Newaskar, Deepak Agrawal
BACKGROUND: Internal derangement of the temporomandibular joint (TMJ) is one of the most common forms of temporomandibular disorders. The minimally invasive treatments such as arthrocentesis as well as arthroscopic lysis and lavage are often used as a first-line surgical treatment or in conjunction with nonsurgical modalities with low morbidity and high efficacy. Sodium hyaluronate (SH) has been proposed as an alternative therapeutic agent with similar therapeutic effects. OBJECTIVE: A prospective study was carried out for evaluation of efficacy of TMJ arthrocentesis with and without injection of SH in management of internal derangements...
October 6, 2016: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27695944/endoscopic-and-clinical-benefits-of-hyaluronic-acid-in-children-with-chronic-adenoiditis-and-middle-ear-disease
#9
S Torretta, P Marchisio, V Rinaldi, D Carioli, E Nazzari, L Pignataro
Hyaluronic acid (HA) is involved in modulating inflammatory airway processes and mucociliary clearance. Some studies have tested the effectiveness of the topical administration of HA in patients with upper airway diseases with positive preliminary results. A prospective, single-blind, 1:1 randomised controlled study was performed to assess the efficacy and safety of the daily topical administration of 9 mg of sodium hyaluronate in 3 mL of a 0.9 % sodium saline solution on the basis of endoscopic and clinical parameters in children with chronic adenoiditis associated with recurrent acute otitis media and otitis media with effusion; age- and gender-matched children receiving normal 0...
October 1, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27688841/safety-of-repeated-injections-of-sodium-hyaluronate-supartz-for-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#10
Raveendhara R Bannuru, Christopher R Brodie, Matthew C Sullivan, Timothy E McAlindon
OBJECTIVE: Though there is no consensus on its efficacy, knee osteoarthritis is symptomatically managed with intra-articular hyaluronic acid (IAHA). Recent reports suggest that IAHA may delay the need for total knee replacement, with the magnitude of delay proportional to the number of injection series. However, the safety of repeated injection series is reported to vary between commercial products. This report describes a systematic review of safety data on repeated treatment courses of SUPARTZ...
October 2016: Cartilage
https://www.readbyqxmd.com/read/27688751/novel-bioceramic-urethral-bulking-agents-elicit-improved-host-tissue-responses-in-a-rat-model
#11
Travis K Mann-Gow, Benjamin J King, Ahmed El-Ghannam, Christine Knabe-Ducheyne, Masatoshi Kida, Ole M Dall, Jan Krhut, Peter Zvara
Objectives. To test the physical properties and host response to the bioceramic particles, silica-calcium phosphate (SCPC10) and Cristobalite, in a rat animal model and compare their biocompatibility to the current clinically utilized urethral bulking materials. Material and Methods. The novel bulking materials, SCPC10 and Cristobalite, were suspended in hyaluronic acid sodium salt and injected into the mid urethra of a rat. Additional animals were injected with bulking materials currently in clinical use. Physiological response was assessed using voiding trials, and host tissue response was evaluated using hard tissue histology and immunohistochemical analysis...
2016: Advances in Urology
https://www.readbyqxmd.com/read/27672901/poster-133-analysis-of-pain-and-functionality-in-knee-osteoarthritis-patients-after-sodium-hyaluronate-viscosupplementation
#12
Erika M Suzigan, Eduardo E Rocha, Cyro Scala
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27669222/keratinocyte-growth-factor-combined-with-a-sodium-hyaluronate-gel-inhibits-postoperative-intra-abdominal-adhesions
#13
Guangbing Wei, Cancan Zhou, Guanghui Wang, Lin Fan, Kang Wang, Xuqi Li
Postoperative intra-abdominal adhesion is a very common complication after abdominal surgery. One clinical problem that remains to be solved is to identify an ideal strategy to prevent abdominal adhesions. Keratinocyte growth factor (KGF) has been proven to improve the proliferation of mesothelial cells, which may enhance fibrinolytic activity to suppress postoperative adhesions. This study investigated whether the combined administration of KGF and a sodium hyaluronate (HA) gel can prevent intra-abdominal adhesions by improving the orderly repair of the peritoneal mesothelial cells...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27659025/formulation-and-characterization-of-polysaccharide-microparticles-for-pulmonary-delivery-of-sodium-cromoglycate
#14
Loreana Gallo, Verónica Bucalá, María Verónica Ramírez-Rigo
Sodium cromoglycate (SC) is an antiasthmatic and antiallergenic drug commonly used for chronic inhalation therapy; however, many daily intakes are required due to the fast drug clearance from airways. For these reasons, SC polymeric particles for inhalatory administration with adequate aerosolization and mucoadhesive properties were designed to prolong the drug residence time in the site of action. Sodium carboxymethylcellulose (CMCNa), sodium hyaluronate, and sodium alginate were selected to co-process SC by spray drying...
September 22, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27658527/pxl01-in-sodium-hyaluronate-results-in-increased-prg4-expression-a-potential-mechanism-for-anti-adhesion
#15
Sara Edsfeldt, Björn Holm, Margit Mahlapuu, Carol Reno, David A Hart, Monica Wiig
PURPOSE: To investigate the anti-adhesive mechanisms of PXL01 in sodium hyaluronate (HA) by using the rabbit lactoferrin peptide, rabPXL01 in HA, in a rabbit model of healing tendons and tendon sheaths. The mechanism of action for PXL01 in HA is interesting since a recent clinical study of the human lactoferrin peptide PXL01 in HA administered around repaired tendons in the hand showed improved digit mobility. MATERIALS AND METHODS: On days 1, 3, and 6 after tendon injury and surgical repair, reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) was used to assess mRNA expression levels for genes encoding the mucinous glycoprotein PRG4 (also called lubricin) and a subset of matrix proteins, cytokines, and growth factors involved in flexor tendon repair...
September 23, 2016: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27647073/-influence-of-covering-of-auto-crosslinked-sodium-hyaluronate-gel-in-combination-with-xenogenic-acellular-dermal-matrix-on-healing-of-full-thickness-skin-defect-wound-in-pig
#16
Y X Qiu, G A Zhang, J B Wan, X Z Zhao
Objective: To explore the influence of covering of auto-crosslinked sodium hyaluronate gel in combination with xenogenic acellular dermal matrix (ADM) on healing of full-thickness skin defect wound in pig. Methods: Totally four 10 cm×10 cm full-thickness skin defect wounds were reproduced symmetrically on both sides of spine on the back of each one of the six Chinese experimental minipigs. After autologous microskin grafting, the 4 wounds in each pig were divided into 4 groups according to the random number table, with 6 wounds in each group...
September 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27645471/evaluation-of-the-safety-cell-migration-and-mucoadhesive-properties-of-a-mucoadhesive-polymer-blend-in-human-oral-mucosa
#17
Guiyun Song, Daniel Banov, August S Bassani, Benigno C Valdez
The efficacy of active pharmaceutical ingredients (API) in compounded medications for oral mucosa greatly depends on the composition of the base. Here, we assessed the safety, facilitation of cell migration, and mucoadhesive properties of a newly developed mucoadhesive polymer blend (MPB) which contains pullulan, tamarindus indica polysaccharide, and sodium hyaluronate. No cell death was observed when human oral keratinocyte (HOK) and fibroblast (HOrF) cells were exposed to 1% MPB for 24 h. Epithelial cells in a 3D buccal tissue model (EpiOral) were unaffected when exposed to 50% MPB for 20 h whereas 1% Triton X-100 killed 93% cells after 4...
September 19, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27640797/-comparison-among-measures-to-prevent-intrauterine-adhesions-after-artificial-abortion
#18
Lei Li, Manman Nai, Guixiang Gao, Luwen Wang
OBJECTIVE: To investigate the clinical efficacy of oral medicine and sodium hyaluronate in prevention of intrauterine adhesions after artificial abortion.
 METHODS: A total of 572 patients with early pregnancy termination through artificial abortion, who experienced two or more times of abortion, were retrospectively analyzed. Patients were randomly and voluntarily divided into 4 groups: an artificial cycle group, a drospirenone and ethinylestradiol tablets group, a sodium hyaluronate group, and a control group...
September 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27617470/diclofenac-sodium-3-gel-for-darier-s-disease-treatment
#19
Sergio Santos-Alarcon, Celia Sanchis-Sanchez, Almudena Mateu-Puchades
BACKGROUND: Darier's disease (DD) is an autosomal dominant skin disorder which causative gene, ATP2A2, is located atchromosome 12q23-24. The lesions of DD are skin-coloured to brown, hyperkeratotic, greasy papules that coalesce into warty plaques commonly involving the seborrhoeic areas of the trunk and face, especially the scalp margins, temples, ears, and scalp. The most common complaint associated with the disease is itching, with exacerbations attributed to heat, sweating, sunlight, lithium, steroid therapy, stress, and menstruation OBJECTIVES: We report a patient with DD treated with topical diclofenac sodium 3%...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27614318/a-two-week-randomized-double-masked-study-to-evaluate-safety-and-efficacy-of-lubricin-150-%C3%AE-g-ml-eye-drops-versus-sodium-hyaluronate-ha-0-18-eye-drops-vismed%C3%A2-in-patients-with-moderate-dry-eye-disease
#20
Alessandro Lambiase, Benjamin D Sullivan, Tannin A Schmidt, David A Sullivan, Gregory Jay, Edward R Truitt, Alice Bruscolini, Marta Sacchetti, Flavio Mantelli
PURPOSE: The objective of this clinical trial (NCT02507934) was to assess the efficacy and safety of recombinant human lubricin as compared to a 0.18% sodium hyaluronate (HA) eye drop in subjects with moderate dry eye disease (DED). METHODS: DEWS Grade 2-3 subjects were randomized to use lubricin (N=19, 51.9±11.8 years) or HA (N=20, 61.8±13.3 years). After a saline washout period, subjects administered BID therapy for 7 days, followed by instillation as needed (2-6 drops per eye) for 7 days...
September 7, 2016: Ocular Surface
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