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sodium hyaluronate

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https://www.readbyqxmd.com/read/29339285/facile-synthesis-and-rheological-characterization-of-nanocomposite-hyaluronan-organoclay-hydrogels
#1
J Mourycová, K K R Datta, A Procházková, M Plotěná, V Enev, J Smilek, J Másílko, M Pekař
We report a facile methodology for the synthesis of inorganic-organic hydrogels based on integrative assembly aminopropyl magnesium phyllosilicate (aminoclay) and sodium salt of hyaluronic acid. The viscoelastic materials produced by electrostatic interactions and crosslinking of hyaluronan in the presence of exfoliated synthetic organoclay results in the formation of gel-like behavior retaining a high amount of water. This was confirmed by a rheological study revealing significant dominance of the elastic response over the entire deformation frequency range used...
January 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29316854/highly-stretchable-ha-sa-hydrogels-for-tissue-engineering
#2
Chengcheng Zhu, Rui Yang, Xiaobin Hua, Hong Chen, Jumei Xu, Rile Wu, Lian Cen
A highly stretchable hyaluronic acid (HA)/sodium alginate (SA) hydrogel was developed in this study based on an interpenetrating polymer network. HA/SA hydrogels were prepared by mixing two polysaccharides followed by covalent crosslinking via epoxy groups on HA molecules and ionic crosslinking via divalent ions on SA chains sequentially. The effect of HA/SA ratio on the pore size and distribution, swelling ratio, elongation and rheological properties as well as protein loading and release properties of HA/SA hydrogels was explored...
January 10, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29291501/cutaneous-wound-healing-using-polymeric-surgical-dressings-based-on-chitosan-sodium-hyaluronate-and-resveratrol-a-preclinical-experimental-study
#3
Cristian Berce, Mihai-Stefan Muresan, Olga Soritau, Bobe Petrushev, Lucia Tefas, Isabella Rigo, Gheorghe Ungureanu, Cornel Catoi, Alexandru Irimie, Ciprian Tomuleasa
Wound healing is a complex and dynamic process that involves modifying the wound environment depending on the patient's health status. Scar formation depends on many factors that influence wound healing, are important to bear in mind because most of the negative factors involved can be stopped by implementing an adequate treatment. The consensus in wound therapy recommends dressings that should keep a moist and alkaline environment thus creating a protective barrier against mechanical stress and secondary infections, in view of promoting granulation...
December 21, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29283977/divergent-effects-of-hypertonic-fluid-resuscitation-on-renal-pathophysiological-and-structural-parameters-in-rat-model-of-lower-body-ischemia-reperfusion-induced-sterile-inflammation
#4
Bulent Ergin, Coert J Zuurbier, Aysegul Kapucu, Can Ince
The pathogenesis of acute kidney injury (AKI) is characterized by the deterioration of tissue perfusion and oxygenation and enhanced inflammation. The purpose of this study was to investigate whether or not the hemodynamic and inflammatory effects of hypertonic saline (HS) protect the kidney by promoting renal microcirculatory oxygenation and possible deleterious effects of HS due to its high sodium content on renal functional and structural injury following ischemia/reperfusion. Mechanically ventilated and anesthetized rats were randomly divided into four groups (n = 6 per group): a sham-operated control group; a group subjected to renal ischemia for 45 min by supra-aortic occlusion followed by 2 h of reperfusion (I/R); and I/R group treated with a continuous i...
December 27, 2017: Shock
https://www.readbyqxmd.com/read/29279118/in-situ-controlled-release-of-stromal-cell-derived-factor-1%C3%AE-and-antimir-138-for-on-demand-cranial-bone-regeneration
#5
Guangsheng Wu, Chao Feng, Jingjing Quan, Zhongshan Wang, Wei Wei, Shengqi Zang, Shuai Kang, Guangyan Hui, Xiguang Chen, Qintao Wang
Bone regeneration involves complex physiological processes, which is generally regulated and controlled by multiple bioactive molecules. In situ controlled release of combined bioactive factors in a spatiotemporal sequence for adapting the demand of bone regeneration is a desired strategy. In this study, nanoparticle/hydrogel composite system was constructed by incorporating stromal cell derived factor-1α (SDF-1α) and chitosan/tripolyphosphate/hyaluronic acid/antimiRNA-138 nanoparticles (CTH/antimiR-138 NPs) in chitosan/β-sodium glycerol phosphate (CS/GP) hydrogel for rat critical-size calvarial bone regeneration...
February 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29244893/effectiveness-of-intra-articular-injections-of-sodium-hyaluronate-or-corticosteroids-for-intracapsular-temporomandibular-disorders-a-systematic-review-and-meta-analysis
#6
Marlon A Moldez, Victor R Camones, Guillermo E Ramos, Mariela Padilla, Reyes Enciso
AIMS: To assess the effectiveness of intra-articular injections of sodium hyaluronate (NaH) or corticosteroids (CS) for treatment of intracapsular temporomandibular disorders (TMD). METHODS: Single- or double-blinded randomized controlled trials (RCTs) on the effectiveness of NaH or CS injections, compared to each other or to placebo, for the treatment of intracapsular TMD due to osteoarthritis and/or internal joint derangement were analyzed in this systematic review and meta-analysis...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29233714/bi-layered-nanocomposite-bandages-for-controlling-microbial-infections-and-overproduction-of-matrix-metalloproteinase-activity
#7
J Anjana, Annapoorna Mohandas, S Seethalakshmy, Maneesha K Suresh, Riju Menon, Raja Biswas, R Jayakumar
Chronic diabetic wounds is characterised by increased microbial contamination and overproduction of matrix metalloproteases that would degrade the extracellular matrix. A bi-layer bandage was developed, that promotes the inhibition of microbial infections and matrix metalloprotease (MMPs) activity. Bi-layer bandage containing benzalkonium chloride loaded gelatin nanoparticles (BZK GNPs) in chitosan-Hyaluronic acid (HA) as a bottom layer and sodium alendronate containing chitosan as top layer was developed. We hypothesized that the chitosan-gelatin top layer with sodium alendronate could inhibit the MMPs activity, whereas the chitosan-HA bottom layer with BZK GNPs (240±66nm) would enable the elimination of microbes...
December 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29230638/application-of-the-sodium-hyaluronate-cntf-scaffolds-in-repairing-adult-rat-spinal-cord-injury-and-facilitating-neural-network-formation
#8
Yabin Xie, Wei Song, Wen Zhao, Yudan Gao, Junkui Shang, Peng Hao, Zhaoyang Yang, Hongmei Duan, Xiaoguang Li
The present study aimed to explore the potential of the sodium hyaluronate-CNTF (ciliary neurotrophic factor) scaffold in activating endogenous neurogenesis and facilitating neural network re-formation after the adult rat spinal cord injury (SCI). After completely cutting and removing a 5-mm adult rat T8 segment, a sodium hyaluronate-CNTF scaffold was implanted into the lesion area. Dil tracing and immunofluorescence staining were used to observe the proliferation, differentiation and integration of neural stem cells (NSCs) after SCI...
December 6, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/29219244/-click-on-plga-peg-and-hyaluronic-acid-gaining-access-to-anti-leishmanial-pentamidine-bioconjugates
#9
Angela Scala, Anna Piperno, Nicola Micale, Placido G Mineo, Antonio Abbadessa, Roberta Risoluti, Germano Castelli, Federica Bruno, Fabrizio Vitale, Antonio Cascio, Giovanni Grassi
Pentamidine (Pent), an antiparasitic drug used for the treatment of visceral leishmaniasis, has been modified with terminal azide groups and conjugated to two different polymer backbones (PLGA-PEG [PP] copolymer and hyaluronic acid [HA]) armed with alkyne end-groups. The conjugation has been performed by Copper Catalyzed Azido Alkyne Cycloaddition (CuAAC) using CuSO4 /sodium ascorbate as metal source. The novel PP-Pent and HA-Pent bioconjugates are proposed, respectively, as non-targeted and targeted drug delivery systems against Leishmania infections...
December 8, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29208274/hemostatic-porous-sponges-of-cross-linked-hyaluronic-acid-cationized-dextran-by-one-self-foaming-process
#10
Jia-Ying Liu, Yang Li, Yang Hu, Gang Cheng, Enyi Ye, Chuanan Shen, Fu-Jian Xu
Effective hemostatic materials are very important for treating trauma cases. Natural polysaccharides have been particularly appealing in the development of new hemostatic materials due to their unique functions in human bodies. In this work, different polysaccharide-based hemostatic porous sponges (SHDP or SHDQ) of cross-linked hyaluronic acid (HA)/cationized dextran were readily prepared by the self-foaming process of HA and poly((2-dimethyl amino)-ethyl methacrylate)-grafted dextran (Dex-PDM) or partially-quaternized Dex-PDM in the presence of sodium trimetaphosphate crosslinkers...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29202566/post-operative-nebulized-sodium-hyaluronate-versus-spray-after-functional-endoscopic-sinus-surgery-for-chronic-rhinosinusitis
#11
M Casale, A Pace, A Moffa, P Vella, L Sabatino, M A Lopez, F Salvinelli
We prospectively evaluated the efficacy of nebulized Hyaluronic Acid (HA) as an adjuvant treatment to hasten the improvement of nasal respiration and to minimize patients’ discomfort in the postoperative functional endoscopic sinus surgery (FESS) for chronic rhino-sinusitis (CRS). We enrolled 33 CRS adult patients who underwent endoscopic functional sinus surgery. They were randomly assigned into two groups: Spray-Sol group (18 patients) with HA nebulized with a new nasal device named Spray-Sol and Spray group (15 patients) with a HA nebulized with a common spray...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202563/topical-hyaluronic-acid-in-rhinitis-medicamentosa-could-our-perspective-be-changed
#12
M Casale, P Vella, A Moffa, L Sabatino, V Rinaldi, V Grimaldi, F Salvinelli
This study was designed to prospectively evaluate the role of nebulized hyaluronic acid (HA) administered for 10 days as treatment for patients with rhinitis medicamentosa (RM). RM is a pathological condition of the nasal mucosa induced by prolonged, excessive or improper use of topical decongestants. It is characterized by persistent nasal congestion that can lead the patient to increase the frequency of application and the quantity of the substance being applied, resulting in dependence on topical nasal decongestants...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29194378/chitosan-nanoparticles-as-a-mucoadhesive-drug-delivery-system-for-ocular-administration
#13
Mariana M Silva, Raquel Calado, Joana Marto, Ana Bettencourt, António J Almeida, Lídia M D Gonçalves
Pharmaceutical approaches based on nanotechnologies and the development of eye drops composed of the mucoadhesive polymers chitosan and hyaluronic acid are emerging strategies for the efficient treatment of ocular diseases. These innovative nanoparticulate systems aim to increase drugs' bioavailability at the ocular surface. For the successful development of these systems, the evaluation of mucoahesiveness (the interaction between the ocular delivery system and mucins present on the eye) is of utmost importance...
December 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29162939/intravesicular-administration-of-sodium-hyaluronate-ameliorates-the-inflammation-and-cell-proliferation-of-cystitis-cystica-et-glandularis-involving-interleukin-6-jak2-stat3-signaling-pathway
#14
Yongliang Ni, Shaohua Zhao, Xiaoxuan Yin, Haixin Wang, Qianqian Guang, Guangxia Hu, Yi Yang, Shoubin Jiao, Benkang Shi
Cystitis cystica et glandularis (CCEG) is a chronic cystitis that causes extreme agony in affected patients. However, there are lack of effective conservative treatments. In this study, it is evident that intravesicular sodium hyaluronate (SH) therapy significantly improved the clinical symptoms of CCEG patients and ameliorated the bladder mucosal inflammation and cell proliferation characteristics of the disease. Immunohistochemical staining showed that the staining intensities of hyaluronidase (HYAL 1/2), CD44, IL-6 and phosphorylated signal transducer and activator of transcription 3 (p-Stat3) in bladder mucosal tissue were significantly increased in CCEG patients compared with control patients and that intravesicular SH treatment suppressed these protein expression...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29139103/differentiation-potential-of-human-adipose-stem-cells-bioprinted-with-hyaluronic-acid-gelatin-based-bioink-through-microextrusion-and-visible-light-initiated-crosslinking
#15
Shinji Sakai, Hiromi Ohi, Tomoki Hotta, Hidenori Kamei, Masahito Taya
Bioprinting has a great potential to fabricate three-dimensional (3D) functional tissues and organs. In particular, the technique enables fabrication of 3D constructs containing stem cells while maintaining cell proliferation and differentiation abilities, which is believed to be promising in the fields of tissue engineering and regenerative medicine. We aimed to demonstrate the utility of the bioprinting technique to create hydrogel constructs consisting of hyaluronic acid (HA) and gelatin derivatives through irradiation by visible light to fabricate 3D constructs containing human adipose stem cells (hADSCs)...
November 15, 2017: Biopolymers
https://www.readbyqxmd.com/read/29138694/impact-of-topically-administered-steroids-antibiotics-and-sodium-hyaluronate-on-bleb-related-infection-onset-the-japan-glaucoma-society-survey-of-bleb-related-infection-report-4
#16
Hideto Sagara, Tetsuya Yamamoto, Kimihiro Imaizumi, Tetsuju Sekiryu
Purpose: To investigate the impact of topically administered ophthalmic medications on the onset and severity of bleb-related infections. Methods: Data obtained from 104 eyes of 104 patients with bleb-related infections were analyzed. We assigned an infection stage to each eye (stage 1-4) and analyzed the onset severity. Results: Steroids and antibiotics were routinely administered to 13 (12.5%) and 42 (40.4%) eyes, respectively. The median stage of steroid-administered eyes was 3 versus 1 for eyes without steroid administration (P = 0...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29110601/drug-release-from-porous-matrixes-based-on-natural-polymers
#17
B Kaczmarek, A Sionkowska
BACKGROUND: This review provides a report on recent advances in the field of drug release from matrixes made of natural polymers. Such matrixes have attracted not only academic but also practical attention in the case of several biopolymers since these can be used for biomedical purposes due to their interesting properties. Herein, the properties of natural polymers such as proteins and polysaccharides are discussed in general. Selected detailed examples of drug release profiles from biopolymer matrixes have also been collected from scientific literature and practical work, and commented on...
November 3, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29108480/short-term-homing-of-hyaluronan-primed-cells-therapeutic-implications-for-osteoarthritis-treatment
#18
Giovanna Desando, Isabella Bartolotti, Carola Cavallo, Antonella Schiavinato, Cynthia Secchieri, Elizaveta Kon, Giuseppe Filardo, Maurizio Paro, Brunella Grigolo
The evaluation of key factors modulating cell homing following transplantation can provide new insights in the comprehension of unsolved biological questions about the use of cell therapies for osteoarthritis (OA). The main purpose of this in vivo study was to investigate the biodistribution of an intra-articular (IA) injection of mesenchymal stromal cells (MSCs) and bone marrow concentrate (BMC) in a rabbit OA model, and whether the additional use of sodium hyaluronate (HA) could modulate their migration and promote joint repair...
November 6, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29103324/collagen-based-porous-scaffolds-containing-plga-microspheres-for-controlled-kartogenin-release-in-cartilage-tissue-engineering
#19
Xiaomin Sun, Jianhua Wang, Yingying Wang, Qiqing Zhang
A scaffold composed of different collagen (COL)/chitosan (CS)/hyaluronic acid sodium (HAS) salt ratios was evaluated by determining porosity, swelling, loss rate in hot water, mechanical property, and cell proliferation to obtain optimum conditions for manufacturing porous scaffolds. Results showed that the optimal ratio of COL/CS/HAS salt porous scaffold was 1:1:0.1. High swelling and loss rate of scaffolds/microspheres (MPs) could lead to high diffusion rate of MPs from the scaffolds, causing an increase in the kartogenin (KGN) release...
November 6, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29077152/pathological-and-cytological-changes-of-the-nasal-mucosa-in-acute-rhinosinusitis-the-role-of-hyaluronic-acid-as-supportive-therapy
#20
A Ciofalo, G Zambetti, G Altissimi, M Fusconi, P Soldo, M Gelardi, G Iannella, B Pasquariello, G Magliulo
OBJECTIVE: The aim of this study was to evaluate the reparative role of hyaluronic acid in acute rhinosinusitis (ARS). PATIENTS AND METHODS: 48 patients affected by ARS were submitted to nasal endoscopy, nasal cytology, mucociliary transport evaluation (MCTt) and visual analogue scale questionnaire (VAS) at T0, after 14-18 days (T1) and after 30-35 days (T2). The patients were randomized into two groups, A and B, and received Levofloxacin and Prednisone. Moreover, using a nebulizer ampoule for nasal douche, Group A received high molecular weight Sodium Hyaluronate (3%) plus saline solution (NaCl 0...
October 2017: European Review for Medical and Pharmacological Sciences
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