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https://www.readbyqxmd.com/read/28207824/evaluation-of-surgical-anti-adhesion-products-to-reduce-postsurgical-intra-abdominal-adhesion-formation-in-a-rat-model
#1
Long-Xiang Lin, Fang Yuan, Hui-Hui Zhang, Ni-Na Liao, Jing-Wan Luo, Yu-Long Sun
BACKGROUND: Adhesions frequently occur after abdominal surgery. Many anti-adhesion products have been used in clinic. However, the evidences are short for surgeons to reasonably choose the suitable anti-adhesion produces in clinical practice. This study provided such evidence by comparing the efficiency of five products to prevent abdominal adhesion formation in a rat model. METHODS: Fifty-six Sprague-Dawley rats were randomly divided into seven groups: sham-operation group, adhesion group, and five product groups (n = 8)...
2017: PloS One
https://www.readbyqxmd.com/read/28182765/rapamycin-sodium-hyaluronate-binding-on-nano-hydroxyapatite-coated-titanium-surface-improves-mc3t3-e1-osteogenesis
#2
Chao Liu, Jian Yong Dong, Lin Lin Yue, Shao Hua Liu, Yi Wan, Hong Liu, Wan Ye Tan, Qian Qian Guo, Dong Zhang
Endosseous titanium (Ti) implant failure due to poor biocompatibility of implant surface remains a major problem for osseointegration. Improving the topography of Ti surface may enhance osseointegration, however, the mechanism remains unknown. To investigate the effect of modified Ti surface on osteogenesis, we loaded rapamycin (RA) onto nano-hydroxyapatite (HAp) coated Ti surface which was acid-etched, alkali-heated and HAp coated sequentially. Sodium hyaluronate (SH) was employed as an intermediate layer for the load of RA, and a steady release rate of RA was maintained...
2017: PloS One
https://www.readbyqxmd.com/read/28163228/a-novel-in-situ-silver-hyaluronan-bio-nanocomposite-fabrics-for-wound-and-chronic-ulcer-dressing-in-vitro-and-in-vivo-evaluations
#3
A M Abdel-Mohsen, J Jancar, R M Abdel-Rahman, L Vojtek, P Hyršl, M Dušková, H Nejezchlebová
In-situ formed hyaluronan/silver (HA/Ag) nanoparticles (NPs) were used to prepare composite fibers/fabrics for the first time. Different concentrations of silver nitrate (1, 2mg/100ml) were added at ambient temperature to sodium hyaluronate solution (40mg/ml), then the pH was increased to 8 by adding sodium hydroxide. The in-situ formed HA/Ag-NPs were used to prepare fibers/nonwoven fabrics by wet-dry-spinning technique (WDST). UV/vis spectroscopy, SEM, TEM, DLS, XPS, XRD and TGA were employed to characterize the structure and composition of the nanocomposite, surface morphology of fiber/fabrics, particle size of Ag-NPs, chemical interactions of Ag(0) and HA functional groups, crystallinity and thermal stability of the wound dressing, respectively...
February 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28157689/differential-mineralization-of-human-dental-pulp-stem-cells-on-diverse-polymers
#4
Christian Apel, Patricia Buttler, Jochen Salber, Anandhan Dhanasingh, Sabine Neuss
In tissue engineering, biomaterials are used as scaffolds for spatial distribution of specific cell types. Biomaterials can potentially influence cell proliferation and extracellular matrix formation, both in positive and negative ways. The aim of the present study was to investigate and compare mineralized matrix production of human dental pulp stem cells (DPSC), cultured on 17 different well-characterized polymers. Osteogenic differentiation of DPSC was induced for 21 days on biomaterials using dexamethasone, L-ascorbic-acid-2-phosphate, and sodium β-glycerophosphate...
February 3, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28155509/skin-delivery-of-epigallocatechin-3-gallate-egcg-and-hyaluronic-acid-loaded-nano-transfersomes-for-antioxidant-and-anti-aging-effects-in-uv-radiation-induced-skin-damage
#5
Kiran S Avadhani, Jyothsna Manikkath, Mradul Tiwari, Misra Chandrasekhar, Ashok Godavarthi, Shimoga M Vidya, Raghu C Hariharapura, Guruprasad Kalthur, Nayanabhirama Udupa, Srinivas Mutalik
The present work attempts to develop and statistically optimize transfersomes containing EGCG and hyaluronic acid to synergize the UV radiation-protective ability of both compounds, along with imparting antioxidant and anti-aging effects. Transfersomes were prepared by thin film hydration technique, using soy phosphatidylcholine and sodium cholate, combined with high-pressure homogenization. They were characterized with respect to size, polydispersity index, zeta potential, morphology, entrapment efficiency, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), in vitro antioxidant activity and ex vivo skin permeation studies...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28142500/hyaluronic-acid-collagen-hydrogel-as-an-alternative-to-alginate-for-long-term-immunoprotected-islet-transplantation
#6
Stephen Harrington, S Janette Williams, Sonia Rawal, Karthik Ramachandran, Lisa Stehno-Bittel
Alginate has long been the material of choice for immunoprotection of islets for its low cost and ability to easily form microspheres. Unfortunately, this seaweed-derived material is notoriously prone to fibrotic overgrowth in vivo, resulting in premature graft failure. The purpose of this study was to test an alternative, hyaluronic acid (HA-COL), for in vitro function, viability and allogeneic islet transplant outcomes in diabetic rats. In vitro studies indicated that the HA-COL gel had diffusion characteristics that would allow small molecules like glucose and insulin to enter and exit the gel, while larger molecules (70 and 500kD dextrans) were impeded from diffusing past the gel edge in 24 hours...
January 31, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28123524/therapeutic-response-to-a-novel-enzyme-targeting-radiosensitization-treatment-kortuc-ii-for-residual-lesions-in-patients-with-stage-iv-primary-breast-cancer-following-induction-chemotherapy-with-epirubicin-and-cyclophosphamide-or-taxane
#7
Nobutaka Aoyama, Yasuhiro Ogawa, Miki Yasuoka, Hitomi Iwasa, Kana Miyatake, Rika Yoshimatsu, Tomoaki Yamanishi, Norihiko Hamada, Taiji Tamura, Kana Kobayashi, Yoriko Murata, Takuji Yamagami, Mitsuhiko Miyamura
Linac-based radiotherapy has a negligible effect on the majority of advanced neoplasms. Therefore, a novel radiosensitization treatment Kochi Oxydol Radiation Therapy for Unresectable Carcinomas II (KORTUC II), which utilizes hydrogen peroxide and sodium hyaluronate was developed. The effectiveness of KORTUC II for the treatment of chemotherapy-resistant supraclavicular lymph node metastases and recurrent breast cancers has previously been demonstrated. The present study evaluated the safety and efficacy of KORTUC II in patients with stage IV primary breast cancer...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28117254/prospective-evaluation-of-intra-articular-sodium-hyaluronate-injection-in-the-ankle
#8
Evelyn P Murphy, Mark Curtin, Niall P McGoldrick, Gerard Thong, Stephen R Kearns
Viscosupplementation by injection of hyaluronic acid into the ankle can be used to provide pain relief and to delay the need for surgery in patients with osteoarthritis of the ankle. In the present investigation, we prospectively evaluated 50 consecutive patients (25 males and 25 females) undergoing a 3-injection protocol of sodium hyaluronate viscosupplementation in the ankle from January 2014 to January 2015. The Foot and Ankle Outcomes Score was used to compare the patients' pre- and post-treatment opinions about their ankle problems...
January 20, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28038751/polyethyleneimine-modified-poly-hyaluronic-acid-particles-with-controllable-antimicrobial-and-anticancer-effects
#9
Nurettin Sahiner, Selin Sagbas, Mehtap Sahiner, Ramesh S Ayyala
Poly(hyaluronic acid) (p(HA)) particles with sizes from few hundred nm to few tens of micrometer were synthesized by using epoxy groups containing crosslinker glycerol diglycidyl ether (GDE) with high yield, 94±5%. P(HA) particles were oxidized by treatment with sodium periodate and then reacted with cationic polyethyleneimine (PEI) at 1:0.5, 1:1, and 1:2 wt ratio of p(HA):PEI to obtain p(HA)-PEI particles. From zeta potential measurements, isoelectronic points of bare p(HA) particles increased to pH 8.7 from 2...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28012591/facile-preparation-of-polysaccharide-functionalized-macroporous-adsorption-resin-for-highly-selective-enrichment-of-glycopeptides
#10
Xudong Sun, Jing Dong, Jinan Li, Mingliang Ye, Weibing Zhang, Junjie Ou
A facile approach for preparation of hydrophilic polysaccharide-functionalized macroporous adsorption resin (MAR) was presented. Polydisperse MAR with approximately 250μm in diameter was synthesized via suspension polymerization and then modified with polysaccharides, sodium hyaluronate (HA) and chitosan (CS), through layer-by-layer (LbL) self-assembly process. The preparation method was facile, low cost and easy to expand production from tens of grams to one kilogram. The resulting MAR@(HA/CS)20 possesses highly hydrophilic property and rapid adsorption behavior...
December 16, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28012304/work-of-separation-a-method-to-assess-intraperitoneal-adhesion-and-healing-of-parietal-peritoneum-in-an-animal-model
#11
Long-Xiang Lin, Fang Yuan, Hui-Hui Zhang, Yu-Long Sun
BACKGROUND: Adhesion grades and adhesion breaking strength are widely used to assess severity of intraperitoneal adhesion in animal models. However, the results of adhesion grades have the large deviations due to vary personal experience. Adhesion breaking strength ignores the details of adhesion. This study introduced work of separation, the energy consumption during breakage of adhesion, to better evaluate intraperitoneal adhesion. METHODS: The intraperitoneal adhesion was induced by traumas created at rat cecum and adjacent abdominal wall...
December 16, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27987834/injectable-hydrogels-prepared-from-partially-oxidized-hyaluronate-and-glycol-chitosan-for-chondrocyte-encapsulation
#12
Do Yoon Kim, Honghyun Park, Sang Woo Kim, Jae Won Lee, Kuen Yong Lee
Hyaluronate has attracted great attention in tissue engineering as a scaffolding material. However, hyaluronate typically requires chemical cross-linking molecules to form hydrogels, which may induce undesirable side effects in the body. In this study, hyaluronate was partially oxidized with sodium periodate to generate aldehyde groups in the backbone, and simply mixed with glycol chitosan to form gels via Schiff base formation. The effects of the degree of oxidization, polymer concentration, and polymer composition on the mechanical properties of oxidized hyaluronate/glycol chitosan hydrogels were investigated in vitro...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27973684/the-impact-of-arthrocentesis-with-and-without-hyaluronic-acid-injection-in-the-prognosis-and-synovial-fluid-myeloperoxidase-levels-of-patients-with-painful-symptomatic-internal-derangement-of-temporomandibular-joint-a-randomized-controlled-clinical-trial
#13
Serap Moroğlu Ozdamar, Burcin Alev, Aysen Yarat
BACKGROUND: We aimed to assess the relationship between myeloperoxidase (MPO) and internal derangement (ID) of temporomandibular joint (TMJ) and effects of arthrocentesis procedure, either alone or in combination with hyaluronic acid (HA) injection on the prognosis of ID of TMJ. METHODS: A prospective randomized controlled trial has been conducted through patients, who underwent arthrocentesis for the treatment of ID of TMJ, were randomly divided into two groups...
December 14, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27955699/adelmidrol-in-combination-with-hyaluronic-acid-displays-increased-anti-inflammatory-and-analgesic-effects-against-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#14
Rosanna Di Paola, Roberta Fusco, Daniela Impellizzeri, Marika Cordaro, Domenico Britti, Valeria Maria Morittu, Maurizio Evangelista, Salvatore Cuzzocrea
BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease produced by a cascade of events that can ultimately lead to joint damage. The aim of this study was to evaluate the effect of adelmidrol, a synthetic palmitoylethanolamide analogue, combined with hyaluronic acid on pain severity and modulation of the inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis. METHODS: OA was induced by intra-articular injection of MIA in the knee joint...
December 12, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27930553/the-effects-of-hyaluronic-acid-on-hemiplegic-shoulder-injury-and-pain-in-patients-with-subacute-stroke-a-randomized-controlled-pilot-study
#15
RANDOMIZED CONTROLLED TRIAL
Yu-Chi Huang, Chau-Peng Leong, Lin Wang, Mei-Ju Chen, Chien-Yi Chuang, Mei-Yun Liaw, Lin-Yi Wang
BACKGROUND: Hemiplegic shoulder pain (HSP) is one of the most common comorbidities in stroke patients with flaccid shoulders. The pain limits functional motor recovery and affects the activities of daily living after acute stroke. This study investigated the effects of hyaluronic acid (HA) injection on pain reduction and motor function in subacute stroke patients with HSP and injury. METHODS: A randomized, double-blinded controlled trial was conducted in a medical center...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929721/a-randomized-multicenter-study-comparing-0-1-0-15-and-0-3-sodium-hyaluronate-with-0-05-cyclosporine-in-the-treatment-of-dry-eye
#16
Yuli Park, Jong Suk Song, Chul Young Choi, Kyung Chul Yoon, Hyung Keun Lee, Hyun Seung Kim
PURPOSE: To investigate the efficacy of 0.1%, 0.15%, and 0.3% sodium hyaluronate (SH) artificial tears compared with 0.05% cyclosporine (CS) ophthalmic solution for the treatment of dry eye. METHODS: One hundred seventy-six patients were recruited and randomized to receive of 0.1%, 0.15%, and 0.3% SH and 0.05% CS. There was a primary end point which is the changes in the fluorescein corneal staining (FCS) score to determine noninferiority of 0.1%, 0.15%, and 0.3% SH...
December 8, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27923698/engineered-sodium-hyaluronate-respirable-dry-powders-for-pulmonary-drug-delivery
#17
Francesco Martinelli, Anna Giulia Balducci, Abhinav Kumar, Fabio Sonvico, Ben Forbes, Ruggero Bettini, Francesca Buttini
Sodium hyaluronate (HYA) warrants attention as a material for inhalation due to its (i) therapeutic potential, (ii) utility as a formulation excipient or drug carrier, and (iii) ability to target lung inflammation and cancer. This study aimed to overcome formulation and manufacturing impediments to engineer biocompatible spray-dried HYA powders for inhalation. Novel methodology was developed to produce HYA microparticles by spray drying. Different types of surfactant were included in the formulation to improve powder respirability, which was evaluated in vitro using cascade impactors...
December 5, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27909627/recurrence-of-childhood-nephrogenic-adenoma-in-urinary-bladder-developed-four-years-after-previous-surgery-despite-intravesical-sodium-hyaluronate-therapy
#18
Burak Özçift, Ayper Kaçar, Hüseyin Tuğrul Tiryaki
Nephrogenic adenoma (NA) is a rarely seen benign metaplastic lesion of the urinary tract. Its etiology is uncertain, but induced by chronic inflammation, irritation, and trauma. NA is located in the urinary tract, most commonly in the bladder. NA usually presents with hematuria and lower urinary tract symptoms. In the literature it is mostly seen in adults but about 30 cases of NA's have been reported in children. Treatment of intravesical lesions consists of transurethral resection (TUR) and fulguration and rarely partial or total cystectomy may be required in ineffective TUR...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27854436/the-influence-of-hyaluronan-addition-on-thickness-weight-uniformity-of-mass-and-water-content-of-mucoadhesive-films
#19
Veronika Walicová, Jan Gajdziok, Markéta Gajdošová, David Vetchý
Characteristics of the buccal mucoadhesive films (film thickness, film weight, uniformity of mass and moisture content) prepared by solvent casting method were tested in this experimental study. The formulations consisted either of one mucoadhesive polymer (sodium hyaluronate of two different molecular weights and sodium carboxymethylcellulose) or combinations thereof. On the basis of the aforementioned tests, it was determined that water content was influenced by the molecular weight of sodium hyaluronate as well as by the ratio of mucoadhesive polymers in the composition...
2016: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/27822014/hyaluronic-acid-and-oxidized-regenerated-cellulose-prevent-adhesion-reformation-after-adhesiolysis-in-rat-models
#20
Yan Zhang, Qin Liu, Ning Yang, Xuegang Zhang
Postsurgical adhesion formation is the most common complication in abdominal and pelvic surgery. Adhesiolysis is the most commonly applied treatment for adhesion formation but is often followed by adhesion reformation. Therefore, an efficient strategy should be adopted to solve these problems. This study aimed to explore whether hyaluronic acid and oxidized regenerated cellulose (ORC) could prevent adhesion formation and reformation. Thirty female Sprague Dawley rats were randomly divided into three groups (n=10 each) and subjected to different treatments during the first and second surgery...
2016: Drug Design, Development and Therapy
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