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sodium hyaluronate

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https://www.readbyqxmd.com/read/28332813/competitive-adsorption-of-polyelectrolytes-onto-and-into-pellicle-coated-hydroxyapatite-investigated-by-qcm-d-and-force-spectroscopy
#1
Hyun-Su Lee, Carl Myers, Lynette Zaidel, Prathima Chandra Nalam, Matthew Alexander Caporizzo, Carlo Daep, David M Eckmann, James G Masters, Russell J Composto
A current effort in preventive dentistry is to inhibit surface attachment of bacteria using antibacterial polymer coatings on the tooth surface. For the antibacterial coatings, the physisorption of anionic and cationic polymers directly onto hydroxyapatite (HA) and saliva treated HA surfaces was studied using quartz crystal microbalance, force spectroscopy and atomic force microscopy. First, single species adsorption is shown to be stronger on HA surfaces than on silicon oxide surfaces for all polymers (i.e...
March 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28325340/low-molecular-weight-xanthan-gum-for-treating-osteoarthritis
#2
Guanying Han, Qixin Chen, Fei Liu, Zan Cui, Huarong Shao, Fuyan Liu, Aibin Ma, Joshua Liao, Bin Guo, Yuewei Guo, Fengshan Wang, Peixue Ling, Xifan Mei
Osteoarthritis (OA) is one of the most common chronic diseases and characterized by degradation of articular cartilage. We have previously reported xanthan gum (XG) injection preparation with high molecular weights (Mw) in ranging from 3×10(6)Da to 5×10(6)Da (HM-XG) could enhance the viscosity of synovial fluid, protect joint cartilage in rabbit, and the therapeutical effect has no significance difference with an existing clinical medication (sodium hyaluronate, SH) at the same injection frequency (once weekly for 5 weeks)...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28317663/mixed-polymeric-systems-new-ophthalmic-viscosurgical-device-created-by-mixing-commercially-available-devices
#3
Daniele Tognetto, Paolo Cecchini, Rossella D'Aloisio, Romano Lapasin
PURPOSE: To evaluate the rheological properties of mixtures of different commercially available ophthalmic viscosurgical devices (OVDs) containing sodium hyaluronate and chondroitin sulfate. SETTING: Eye Clinic, University of Trieste, Trieste, Italy. DESIGN: Laboratory study. METHODS: Blends were obtained combining a superviscous cohesive OVD (Healon GV [sodium hyaluronate 1%]) and a medium-viscosity dispersive OVD (Viscoat [sodium hyaluronate 3...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28297834/-effect-of-inhibiting-perivascular-adhesion-on-intimal-hyperplasia-of-the-vein-grafts-in-rabbits
#4
M K Guo, J X Zhu, C M Han, T Bao, D Yang, P Yu, Y F Duan, F L Fan, H G Zhang, H J Tian
Objective: To investigate the effect of preventing perivascular adhesion with topical application of sodium hyaluronate on intimal hyperplasia of the vein grafts in rabbits. Methods: Twenty-four male New Zealand white rabbits, aged 5 months, were randomly divided into 2 groups: Group A and B (n=12 rabbits per group). Artery defect model was established by cutting about 1 cm artery from the middle part of the dissociated left common carotid artery. A section about 3 cm was cut from the right external jugular vein, and the harvested vein was inverted and end-to-end anastomosed to the artery defect...
March 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28291206/-potential-for-use-of-hydroxypropyl-guar-in-tear-substitute-therapy
#5
V V Brzhesky, S Yu Golubev
Of the large number of polymers used in artificial tear formulations, natural polysaccharides - hydroxypropyl guar, sodium hyaluronate, chondroitin sulfate, dextran, etc., are gaining more and more popularity. Hydroxypropyl guar stands out through its ability to form a long-lasting structured matrix adhered to the damaged ocular surface and ensuring good wettability of the latter and regeneration of epithelial cells. At that, the viscosity of hydroxypropyl guar increases with increasing tear pH (which, in turn, correlates with the severity of xerosis) and further prolongs the moisturizing effect...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28279059/-clinical-application-and-observation-of-injectable-modified-sodium-hyaluronate-gel-filler-for-facial-cosmetic-surgery
#6
H J Zhang, B Yu, F Niu, J F Liu, Y Chen, Q Jin
Objective: To evaluate the clinical effect of injectable modified sodium hyaluronate gel filler in the treatment of facial profile modification and rejuvenation. Methods: A total of 125 patients who received facial injection of hyaluronate gel from October 2013 to October 2015 were collected. The patients included 62 cases for rhinoplasty, 28 for chin augmentation, 20 for nasolabial fold correction and 15 for lacrimal groove correction. The post-operation results, satisfaction survey and adverse reaction were observed...
March 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28261739/structural-behaviour-of-sodium-hyaluronate-in-concentrated-oppositely-charged-surfactant-solutions
#7
Philipp Buchold, Ralf Schweins, Zhenyu Di, Michael Gradzielski
This work discusses the polyelectrolyte sodium hyaluronate (HA) and its polyelectrolyte/surfactant complexes (PESCs) with tetradecyltrimethylammonium bromide (TTAB) in the semi-dilute regime of HA and at high concentrations of TTAB. The structure and flow properties in the surfactant excess region were studied by light scattering and small angle neutron scattering (SANS) as well as by rheology. The unique behaviour of HA to maintain its high viscosity was observed even at very high TTAB concentrations of 496 mM and this effect was systematically studied in the concentration range from 1 to 25 mM HA...
March 6, 2017: Soft Matter
https://www.readbyqxmd.com/read/28253424/botulinum-toxin-for-the-treatment-of-strabismus
#8
REVIEW
Fiona J Rowe, Carmel P Noonan
BACKGROUND: The use of botulinum toxin as an investigative and treatment modality for strabismus is well reported in the medical literature. However, it is unclear how effective it is in comparison to other treatment options for strabismus. OBJECTIVES: The primary objective was to examine the efficacy of botulinum toxin therapy in the treatment of strabismus compared with alternative conservative or surgical treatment options. This review sought to ascertain those types of strabismus that particularly benefit from the use of botulinum toxin as a treatment option (such as small angle strabismus or strabismus with binocular potential, i...
March 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28207824/evaluation-of-surgical-anti-adhesion-products-to-reduce-postsurgical-intra-abdominal-adhesion-formation-in-a-rat-model
#9
Long-Xiang Lin, Fang Yuan, Hui-Hui Zhang, Ni-Na Liao, Jing-Wan Luo, Yu-Long Sun
BACKGROUND: Adhesions frequently occur after abdominal surgery. Many anti-adhesion products have been used in clinic. However, the evidences are short for surgeons to reasonably choose the suitable anti-adhesion produces in clinical practice. This study provided such evidence by comparing the efficiency of five products to prevent abdominal adhesion formation in a rat model. METHODS: Fifty-six Sprague-Dawley rats were randomly divided into seven groups: sham-operation group, adhesion group, and five product groups (n = 8)...
2017: PloS One
https://www.readbyqxmd.com/read/28182765/rapamycin-sodium-hyaluronate-binding-on-nano-hydroxyapatite-coated-titanium-surface-improves-mc3t3-e1-osteogenesis
#10
Chao Liu, Jian Yong Dong, Lin Lin Yue, Shao Hua Liu, Yi Wan, Hong Liu, Wan Ye Tan, Qian Qian Guo, Dong Zhang
Endosseous titanium (Ti) implant failure due to poor biocompatibility of implant surface remains a major problem for osseointegration. Improving the topography of Ti surface may enhance osseointegration, however, the mechanism remains unknown. To investigate the effect of modified Ti surface on osteogenesis, we loaded rapamycin (RA) onto nano-hydroxyapatite (HAp) coated Ti surface which was acid-etched, alkali-heated and HAp coated sequentially. Sodium hyaluronate (SH) was employed as an intermediate layer for the load of RA, and a steady release rate of RA was maintained...
2017: PloS One
https://www.readbyqxmd.com/read/28163228/a-novel-in-situ-silver-hyaluronan-bio-nanocomposite-fabrics-for-wound-and-chronic-ulcer-dressing-in-vitro-and-in-vivo-evaluations
#11
A M Abdel-Mohsen, J Jancar, R M Abdel-Rahman, L Vojtek, P Hyršl, M Dušková, H Nejezchlebová
In-situ formed hyaluronan/silver (HA/Ag) nanoparticles (NPs) were used to prepare composite fibers/fabrics for the first time. Different concentrations of silver nitrate (1, 2mg/100ml) were added at ambient temperature to sodium hyaluronate solution (40mg/ml), then the pH was increased to 8 by adding sodium hydroxide. The in-situ formed HA/Ag-NPs were used to prepare fibers/nonwoven fabrics by wet-dry-spinning technique (WDST). UV/vis spectroscopy, SEM, TEM, DLS, XPS, XRD and TGA were employed to characterize the structure and composition of the nanocomposite, surface morphology of fiber/fabrics, particle size of Ag-NPs, chemical interactions of Ag(0) and HA functional groups, crystallinity and thermal stability of the wound dressing, respectively...
February 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28157689/differential-mineralization-of-human-dental-pulp-stem-cells-on-diverse-polymers
#12
Christian Apel, Patricia Buttler, Jochen Salber, Anandhan Dhanasingh, Sabine Neuss
In tissue engineering, biomaterials are used as scaffolds for spatial distribution of specific cell types. Biomaterials can potentially influence cell proliferation and extracellular matrix formation, both in positive and negative ways. The aim of the present study was to investigate and compare mineralized matrix production of human dental pulp stem cells (DPSC), cultured on 17 different well-characterized polymers. Osteogenic differentiation of DPSC was induced for 21 days on biomaterials using dexamethasone, L-ascorbic-acid-2-phosphate, and sodium β-glycerophosphate...
February 3, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28155509/skin-delivery-of-epigallocatechin-3-gallate-egcg-and-hyaluronic-acid-loaded-nano-transfersomes-for-antioxidant-and-anti-aging-effects-in-uv-radiation-induced-skin-damage
#13
Kiran S Avadhani, Jyothsna Manikkath, Mradul Tiwari, Misra Chandrasekhar, Ashok Godavarthi, Shimoga M Vidya, Raghu C Hariharapura, Guruprasad Kalthur, Nayanabhirama Udupa, Srinivas Mutalik
The present work attempts to develop and statistically optimize transfersomes containing EGCG and hyaluronic acid to synergize the UV radiation-protective ability of both compounds, along with imparting antioxidant and anti-aging effects. Transfersomes were prepared by thin film hydration technique, using soy phosphatidylcholine and sodium cholate, combined with high-pressure homogenization. They were characterized with respect to size, polydispersity index, zeta potential, morphology, entrapment efficiency, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), in vitro antioxidant activity and ex vivo skin permeation studies...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28142500/hyaluronic-acid-collagen-hydrogel-as-an-alternative-to-alginate-for-long-term-immunoprotected-islet-transplantation
#14
Stephen Harrington, S Janette Williams, Sonia Rawal, Karthik Ramachandran, Lisa Stehno-Bittel
Alginate has long been the material of choice for immunoprotection of islets for its low cost and ability to easily form microspheres. Unfortunately, this seaweed-derived material is notoriously prone to fibrotic overgrowth in vivo, resulting in premature graft failure. The purpose of this study was to test an alternative, hyaluronic acid (HA-COL), for in vitro function, viability and allogeneic islet transplant outcomes in diabetic rats. In vitro studies indicated that the HA-COL gel had diffusion characteristics that would allow small molecules like glucose and insulin to enter and exit the gel, while larger molecules (70 and 500kD dextrans) were impeded from diffusing past the gel edge in 24 hours...
January 31, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28123524/therapeutic-response-to-a-novel-enzyme-targeting-radiosensitization-treatment-kortuc-ii-for-residual-lesions-in-patients-with-stage-iv-primary-breast-cancer-following-induction-chemotherapy-with-epirubicin-and-cyclophosphamide-or-taxane
#15
Nobutaka Aoyama, Yasuhiro Ogawa, Miki Yasuoka, Hitomi Iwasa, Kana Miyatake, Rika Yoshimatsu, Tomoaki Yamanishi, Norihiko Hamada, Taiji Tamura, Kana Kobayashi, Yoriko Murata, Takuji Yamagami, Mitsuhiko Miyamura
Linac-based radiotherapy has a negligible effect on the majority of advanced neoplasms. Therefore, a novel radiosensitization treatment Kochi Oxydol Radiation Therapy for Unresectable Carcinomas II (KORTUC II), which utilizes hydrogen peroxide and sodium hyaluronate was developed. The effectiveness of KORTUC II for the treatment of chemotherapy-resistant supraclavicular lymph node metastases and recurrent breast cancers has previously been demonstrated. The present study evaluated the safety and efficacy of KORTUC II in patients with stage IV primary breast cancer...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28117254/prospective-evaluation-of-intra-articular-sodium-hyaluronate-injection-in-the-ankle
#16
Evelyn P Murphy, Mark Curtin, Niall P McGoldrick, Gerard Thong, Stephen R Kearns
Viscosupplementation by injection of hyaluronic acid into the ankle can be used to provide pain relief and to delay the need for surgery in patients with osteoarthritis of the ankle. In the present investigation, we prospectively evaluated 50 consecutive patients (25 males and 25 females) undergoing a 3-injection protocol of sodium hyaluronate viscosupplementation in the ankle from January 2014 to January 2015. The Foot and Ankle Outcomes Score was used to compare the patients' pre- and post-treatment opinions about their ankle problems...
March 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28038751/polyethyleneimine-modified-poly-hyaluronic-acid-particles-with-controllable-antimicrobial-and-anticancer-effects
#17
Nurettin Sahiner, Selin Sagbas, Mehtap Sahiner, Ramesh S Ayyala
Poly(hyaluronic acid) (p(HA)) particles with sizes from few hundred nm to few tens of micrometer were synthesized by using epoxy groups containing crosslinker glycerol diglycidyl ether (GDE) with high yield, 94±5%. P(HA) particles were oxidized by treatment with sodium periodate and then reacted with cationic polyethyleneimine (PEI) at 1:0.5, 1:1, and 1:2 wt ratio of p(HA):PEI to obtain p(HA)-PEI particles. From zeta potential measurements, isoelectronic points of bare p(HA) particles increased to pH 8.7 from 2...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28012591/facile-preparation-of-polysaccharide-functionalized-macroporous-adsorption-resin-for-highly-selective-enrichment-of-glycopeptides
#18
Xudong Sun, Jing Dong, Jinan Li, Mingliang Ye, Weibing Zhang, Junjie Ou
A facile approach for preparation of hydrophilic polysaccharide-functionalized macroporous adsorption resin (MAR) was presented. Polydisperse MAR with approximately 250μm in diameter was synthesized via suspension polymerization and then modified with polysaccharides, sodium hyaluronate (HA) and chitosan (CS), through layer-by-layer (LbL) self-assembly process. The preparation method was facile, low cost and easy to expand production from tens of grams to one kilogram. The resulting MAR@(HA/CS)20 possesses highly hydrophilic property and rapid adsorption behavior...
December 16, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28012304/work-of-separation-a-method-to-assess-intraperitoneal-adhesion-and-healing-of-parietal-peritoneum-in-an-animal-model
#19
Long-Xiang Lin, Fang Yuan, Hui-Hui Zhang, Yu-Long Sun
BACKGROUND: Adhesion grades and adhesion breaking strength are widely used to assess severity of intraperitoneal adhesion in animal models. However, the results of adhesion grades have the large deviations due to vary personal experience. Adhesion breaking strength ignores the details of adhesion. This study introduced work of separation, the energy consumption during breakage of adhesion, to better evaluate intraperitoneal adhesion. METHODS: The intraperitoneal adhesion was induced by traumas created at rat cecum and adjacent abdominal wall...
December 16, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27987834/injectable-hydrogels-prepared-from-partially-oxidized-hyaluronate-and-glycol-chitosan-for-chondrocyte-encapsulation
#20
Do Yoon Kim, Honghyun Park, Sang Woo Kim, Jae Won Lee, Kuen Yong Lee
Hyaluronate has attracted great attention in tissue engineering as a scaffolding material. However, hyaluronate typically requires chemical cross-linking molecules to form hydrogels, which may induce undesirable side effects in the body. In this study, hyaluronate was partially oxidized with sodium periodate to generate aldehyde groups in the backbone, and simply mixed with glycol chitosan to form gels via Schiff base formation. The effects of the degree of oxidization, polymer concentration, and polymer composition on the mechanical properties of oxidized hyaluronate/glycol chitosan hydrogels were investigated in vitro...
February 10, 2017: Carbohydrate Polymers
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