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https://www.readbyqxmd.com/read/28806821/endoscopic-submucosal-dissection-of-colitis-related-dysplasia
#1
Noriko Suzuki, Takashi Toyonaga, James E East
Background and study aims Endoscopic submucosal dissection (ESD) offers en bloc resection of lesions, allowing precise pathological assessment. Although possible in ulcerative colitis (UC) patients, the chronic inflammation may increase the procedural risks and reduce the complete resection rate. The aim of this study was to assess the feasibility of ESD for UC and to consider the factors contributing to its technical difficulty. Patients and methods Multicenter experiences of ESD for UC were retrospectively analyzed by reviewing endoscopic videos, pictures, reports, and clinical notes...
August 14, 2017: Endoscopy
https://www.readbyqxmd.com/read/28806590/how-multi-segmental-patterns-deviate-in-spastic-diplegia-from-typical-developed
#2
Matteo Zago, Chiarella Sforza, Alessia Bona, Veronica Cimolin, Pier Francesco Costici, Claudia Condoluci, Manuela Galli
BACKGROUND: The relationship between gait features and coordination in children with Cerebral Palsy is not sufficiently analyzed yet. Principal Component Analysis can help in understanding motion patterns decomposing movement into its fundamental components (Principal Movements). This study aims at quantitatively characterizing the functional connections between multi-joint gait patterns in Cerebral Palsy. METHODS: 65 children with spastic diplegia aged 10.6 (SD 3...
August 8, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28806562/zika-virus-induced-neurological-critical-illness-in-latin-america-severe-guillain-barre-syndrome-and-encephalitis
#3
Sebastián U Ugarte, Angel Ricardo V Arenas, Bruno C Alvarez, Angela Cubides, Angélica F Luna, Max Arroyo-Parejo, Cayri E Acuña, Agamenón V Quintero, Orlando Ch Villareal, Oscar S Pinillos, Elías Vieda, Manuel Bello, Susana Peña, Carmelo Dueñas-Castell, Gloria M V Rodriguez, Jorge L M Ranero, Rosa L M López, Sandra G Olaya, José C Vergara, Ana Tandazo, Juan P S Ospina, Igor M Leyton Soto, R A Fowler, John C Marshall
Zika virus (ZIKAV) is classically described as causing minor symptoms in adult patients, however neurologic complications have been recognized. The recent outbreak in Central and South America has resulted in serious illness in some adult patients. We report adult patients in Latin America diagnosed with ZIKAV infection admitted to Intensive Care Units (ICUs). METHODS: Multicenter, prospective case series of adult patients with laboratory diagnosis of ZIKAV in 16 ICUs in 8 countries. RESULTS: Between December 1st 2015 and April 2nd 2016, 16 ICUs in 8 countries enrolled 49 critically ill patients with diagnosis of ZIKAV infection...
August 9, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28805587/osteoporosis-a-hidden-nonmotor-face-of-parkinson-s-disease
#4
Vinod Metta, Tamara C Sanchez, Chandrasekhara Padmakumar
Osteoporosis is a "hidden nonmotor face" of Parkinson's disease and a cause of considerable morbidity in the older general population and in Parkinson's disease patients. Some regard this as a "hidden epidemic." Women are overrepresented and have considerable problems related to osteoporosis. In general osteoporosis leads to reduced mobility aggravating the motor syndrome of PD. The nonmotor aspects and impact of osteoporosis in PD have remained unexplored. Possible nonmotor consequences include a range of pain syndromes related to local pain, fractures, falls, and injuries as well as pathological fractures and radiculopathy...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28805420/expanding-our-reach-increasing-the-role-of-psychologists-in-public-and-community-mental-health
#5
Erika R Carr, Rebecca Miller
Psychologists are currently underrepresented in community and public mental health settings, despite the advanced training and competencies that are salient for service in various unique and important functions in the public sector. This article will explore those functions including: transformation to recovery-oriented care, delivery of positive behavioral support, implementation and evaluation of evidence-based interventions, application of scholarly guided practice, emphasis on context, therapeutic relationship, and history in therapeutic interventions, provision of training, education, program development and evaluation, and development of leadership and leadership training in systems of care...
August 2017: Psychological Services
https://www.readbyqxmd.com/read/28805270/histoplasmosis-in-transplant-recipients
#6
REVIEW
Kiran Gajurel, Reshika Dhakal, Stan Deresinski
Histoplasma capsulatum is a dimorphic fungus that most often causes asymptomatic infection in the immunocompetent population. In immunocompromised patients, including solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, however, it is likely to cause severe life-threatening infection. Post-transplant histoplasmosis (PTH) in SOT is uncommon with an incidence of ≤ 1% and is even rarer in HCT patients. The majority of PTH in SOT is diagnosed in the first 2 years following transplantation...
August 14, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28805227/landscape-of-the-structure-o-h-bond-dissociation-energy-relationship-of-oximes-and-hydroxylamines
#7
Rina Dao, Xinyu Wang, Kexian Chen, Chenxuan Zhao, Jia Yao, Haoran Li
The relationship between the homolytic O-H bond dissociation enthalpies (BDEs) and the structures of N-oxyl radical precursors (i.e. hydroxylamines and oximes) is important to predict their reactivity. Yet several crucial facts remain hidden to complete the picture such as the substituent electronic effects on the BDEs of oximes. In this work, the O-H BDEs of 120 hydroxylamines and 120 oximes have been calculated. It was found that the majority of the iminoxyl radicals are σ radicals, except for some π radicals...
August 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28805194/-lung-cancer-and-copd-growing-clinical-problem
#8
EDITORIAL
Michal Tyl, Joanna Domagała-Kulawik
A spread of the addiction of tobacco smoking is valued on near 1 billion of people in the world, that involves growing number of morbidity and mortality by the reason of smoke related diseases. Lung cancer and chronic obstructive pulmonary disease (COPD) are the most serious and incurable diseases which are leading to a permanent disability as well as to premature death. There are factors that naturally increase the vulnerability of an individual on the coincidence of above disorders, such as pathophysiological conditions, systemic inflammation, bronchitis, emphysema, respiratory obstructive disease and precise genetic predispositions for COPD and lung cancer...
July 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28805133/the-shape-of-things-to-come-in-speech-production-visual-form-interference-during-lexical-access
#9
Greig I de Zubicaray, Mia McLean, Frank Oppermann, Aidan Hegarty, Katie McMahon, Jörg D Jescheniak
Naming a picture is slower in categorically related compared to unrelated contexts, an effect termed semantic interference. This effect has informed the development of all contemporary models of lexical access in speech production. However, category members typically share visual features, so semantic interference might in part reflect this confound. Surprisingly little work has addressed this issue, and the relative absence of evidence for visual form interference has been proposed to be problematic for production models implementing competitive lexical selection mechanisms...
August 13, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28805131/brain-positron-emission-tomography-with-2-18-f-2-deoxi-d-glucose-of-patients-with-dystonia-and-essential-tremor-detects-differences-between-these-disorders
#10
Vadim Belenky, Andrei Stanzhevsky, Olga Klicenko, Alexandr Skoromets
We studied patients with dystonia (D) and essential tremor (ET) using positron emission tomography (PET) equipped with Cortex ID software. This allowed PET brain visualisation to be compared to scans of a control group by means of the z-score. The study revealed hypo-metabolism in both D and ET groups, and additionally revealed a difference between these two groups of patients in certain areas of the brain. These two nosological forms overlap in clinical features and are difficult to differentiate. The PET picture may help to provide a differential diagnosis in addition to the biochemical difference in dopamine exchange previously revealed by us in this group of patients...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28804444/intrinsic-and-antipsychotic-drug-induced-metabolic-dysfunction-in-schizophrenia
#11
Zachary Freyberg, Despoina Aslanoglou, Ripal Shah, Jacob S Ballon
For decades, there have been observations demonstrating significant metabolic disturbances in people with schizophrenia including clinically relevant weight gain, hypertension, and disturbances in glucose and lipid homeostasis. Many of these findings pre-date the use of antipsychotic drugs (APDs) which on their own are also strongly associated with metabolic side effects. The combination of APD-induced metabolic changes and common adverse environmental factors associated with schizophrenia have made it difficult to determine the specific contributions of each to the overall metabolic picture...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28803651/using-national-hip-fracture-registries-and-audit-databases-to-develop-an-international-perspective
#12
Antony Johansen, David Golding, Louise Brent, Jacqueline Close, Jan-Erik Gjertsen, Graeme Holt, Ami Hommel, Alma B Pedersen, Niels Dieter Röck, Karl-Göran Thorngren
Hip fracture is the commonest reason for older people to need emergency anaesthesia and surgery, and leads to prolonged dependence for many of those who survive. People with this injury are usually identified very early in their hospital care, so hip fracture is an ideal marker condition with which to audit the care offered to older people by health services around the world. We have reviewed the reports of eight national audit programmes, to examine the approach used in each, and highlight differences in case mix, management and outcomes in different countries...
August 2, 2017: Injury
https://www.readbyqxmd.com/read/28803598/adapting-the-standardised-computer-and-interview-based-24-h-dietary-recall-method-globodiet-for-dietary-monitoring-in-latin-america
#13
Silvia Bel-Serrat, Viktoria Knaze, Genevieve Nicolas, Dirce M Marchioni, Josiane Steluti, Aline Mendes, Sandra P Crispim, Regina M Fisberg, Rosangela A Pereira, Marina C Araujo, Rosely Sichieri, Edna M Yokoo, Tania Sánchez-Pimienta, Tania C Aburto, Lilia S Pedraza, Nadia Slimani
OBJECTIVE: The present study describes the procedure and approaches needed to adapt and harmonise the GloboDiet methodology, a computer- and interview-based 24 h dietary recall, for use in two Latin American pilot countries, Brazil and Mexico. DESIGN: About seventy common and country-specific databases on foods, recipes, dietary supplements, quantification methods and coefficients were customised and translated following standardised guidelines, starting from existing Spanish and Portuguese versions...
August 14, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28803450/manoeuvre-to-aid-endoscopic-division-of-aryepiglottic-folds-aryepiglottoplasty
#14
Salil Sood, Raymond Clarke, Andrew Bowhay, Sujata De
Laryngomalacia, a congenital malformation of larynx is the commonest cause of stridor in young infants. Ninety percent of cases resolve by the age of 2 years without any active intervention (1).The most consistent abnormality seen in non-resolving cases is shortening of the aryepiglottic folds (picture 1).(2) This article is protected by copyright. All rights reserved.
August 13, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28802924/the-status-of-nonmotor-features-of-the-malady-in-an-essay-on-the-shaking-palsy-1817
#15
Brian Hurwitz
This chapter examines the status James Parkinson accorded "nonmotor" features of the malady set out in his 1817 Essay. In reading the Essay through the lens of this recently developed dichotomy I use "nonmotor" to mean the application of a late 20th-century category to a 200 year old account, whereas nonmotor designates application of the concept to contemporary understanding. While Parkinson granted "motor" components of the malady high definitional visibility, the Essay shows he was also attentive to patients' overall well-being and noticed some "nonmotor" aspects of the malady, in particular, constipation, interrupted speech, and difficulties with saliva and swallowing...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28802455/from-control-to-causation-validating-a-complex-systems-model-of-running-related-injury-development-and-prevention
#16
A Hulme, P M Salmon, R O Nielsen, G J M Read, C F Finch
INTRODUCTION: There is a need for an ecological and complex systems approach for better understanding the development and prevention of running-related injury (RRI). In a previous article, we proposed a prototype model of the Australian recreational distance running system which was based on the Systems Theoretic Accident Mapping and Processes (STAMP) method. That model included the influence of political, organisational, managerial, and sociocultural determinants alongside individual-level factors in relation to RRI development...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28802272/transcriptional-analysis-of-an-ammonium-excreting-strain-of-azotobacter-vinelandii-deregulated-for-nitrogen-fixation
#17
Brett M Barney, Mary H Plunkett, Velmurugan Natarajan, Florence Mus, Carolann M Knutson, John W Peters
Biological nitrogen fixation is accomplished by a diverse group of organisms known as diazotrophs, and requires the function of the complex metalloenzyme nitrogenase. Nitrogenase and many of the accessory proteins required for proper cofactor biosynthesis and incorporation into the enzyme have been characterized, but a complete picture of the reaction mechanism and key cellular changes that accompany biological nitrogen fixation remain to be fully elucidated. Studies have revealed that specific disruptions to the anti-activator encoding gene nifL result in the deregulation of the nif transcriptional activator NifA in the nitrogen-fixing bacterium Azotobacter vinelandii, triggering the production of extracellular ammonium levels approaching 30 mM during the stationary phase of growth...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28801866/neurosecretion-what-can-we-learn-from-chromaffin-cells
#18
REVIEW
Erwin Neher
Many of the molecular players in the stimulus-secretion chain are similarly active in neurosecretion and catecholamine release. Therefore, studying chromaffin cells uncovered many details of the processes of docking, priming, and exocytosis of vesicles. However, morphological specializations at synapses, called active zones (AZs), confer extra speed of response and another layer of control to the fast release of vesicles by action potentials. Work at the Calyx of Held, a glutamatergic nerve terminal, has shown that in addition to such rapidly released vesicles, there is a pool of "Slow Vesicles," which are held to be perfectly release-competent, but lack a final step of tight interaction with the AZ...
August 11, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28801730/prospective-changes-in-neural-alcohol-cue-reactivity-in-at-risk-adolescents
#19
Tam T Nguyen-Louie, Kelly E Courtney, Lindsay M Squeglia, Kara Bagot, Sonja Eberson, Robyn Migliorini, Alexis R Alcaraz, Susan F Tapert, Carmen Pulido
Adolescence represents an ideal time for elucidating the etiology of cue reactivity profiles. This study examined the influence of three risk factors consistently associated with heavy adolescent drinking on alcohol cue reactivity. Youth were first assessed while still naïve to alcohol (12-14 years old) and followed after transitioning into alcohol use (17-21 years old). The effects of family history of substance use disorder, sex, and history of early of dating (i.e., before 14 years of age) on BOLD response contrast to alcohol picture cues were examined in a linear mixed model, controlling for age and alcohol use patterns at follow-up...
August 11, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28801508/intricate-and-cell-type-specific-populations-of-endogenous-circular-dna-eccdna-in-caenorhabditis-elegans-and-homo-sapiens
#20
Massa J Shoura, Idan Gabdank, Loren Hansen, Jason Merker, Jason Gotlib, Stephen D Levene, Andrew Z Fire
Investigations aimed at defining the 3-D configuration of eukaryotic chromosomes have consistently encountered an endogenous population of chromosome-derived circular genomic DNA, referred to as extrachromosomal circular DNA (eccDNA). While the production, distribution, and activities of eccDNAs remain understudied, eccDNA formation from specific regions of the linear genome has profound consequences on the regulatory and coding capabilities for these regions. Here, we define eccDNA distributions in C. elegans and in three human cell types, utilizing a set of DNA-topology dependent approaches for enrichment and characterization...
August 11, 2017: G3: Genes—Genomes—Genetics
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