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https://www.readbyqxmd.com/read/29036623/predictors-of-mortality-in-high-risk-patients-with-qt-prolongation-in-a-community-hospital
#1
Charlotte Gibbs, Jacob Thalamus, Kristian Heldal, Øystein Lunde Holla, Kristina H Haugaa, Jan Hysing
Aims: To determine predictors of mortality in patients with corrected QT interval (QTc) ≥ 500 ms in a community hospital. Methods and results: In this retrospective observational study, we searched the electrocardiogram (ECG) database at Telemark Hospital Trust, Norway, from January 2004 to December 2014. Medication, electrolyte abnormalities, and medical conditions known to prolong the QT interval were recorded. From the medical records, we assessed whether the prolonged QTc was noted by the health care providers...
October 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036559/the-brisk-standing-test-for-long-qt-syndrome-in-prepubertal-school-children-defining-normal
#2
L H P M Filippini, P G Postema, K Zoubin, B J M Hermans, N A Blom, T Delhaas, A A M Wilde
Aims: Long QT syndrome (LQTS) is associated with malignant arrhythmias and sudden death from birth to advanced age. Prolongation of the QT-interval, may however be concealed on standard electrocardiograms (ECG). The brisk-standing-test (BST) was developed to guide LQTS-diagnosis and treatment in adults. We hypothesized that the BST may be used in prepubertal children to identify LQTS subjects. Accordingly, reference values for the BST should be available to prevent incorrect diagnosis and treatment of LQTS...
October 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29029798/effect-of-intravenous-ondansetron-on-qtc-interval-in-children-with-gastroenteritis
#3
Robert J Hoffman, Khalid Alansari
BACKGROUND: The potential for ondansetron to cause QT prolongation and fatal dysrhythmia is well-reported, including a 2011 FDA report on the topic. Few clinical trials evaluating this phenomenon in the ED setting exist, and only one is pediatric. OBJECTIVE: We have sought to determine the effect of a standardized dose of intravenous ondansetron on the QTc duration of children under 14years of age treated for gastroenteritis-associated vomiting in a pediatric ED...
October 4, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29029613/right-precordial-directed-electrocardiographical-markers-identify-arrhythmogenic-right-ventricular-cardiomyopathy-in-the-absence-of-conventional-depolarization-or-repolarization-abnormalities
#4
Daniel Cortez, Anneli Svensson, Jonas Carlson, Sharon Graw, Nandita Sharma, Francesca Brun, Anita Spezzacatene, Luisa Mestroni, Pyotr G Platonov
BACKGROUND: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries a risk of sudden death. We aimed to assess whether vectorcardiographic (VCG) parameters directed toward the right heart and a measured angle of the S-wave would help differentiate ARVD/C with otherwise normal electrocardiograms from controls. METHODS: Task Force 2010 definite ARVD/C criteria were met for all patients. Those who did not fulfill Task Force depolarization or repolarization criteria (-ECG) were compared with age and gender-matched control subjects...
October 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29027608/ivabradine-in-postural-orthostatic-tachycardia-syndrome-preliminary-experience-in-children
#5
Grazia Delle Donne, Ferran Rosés Noguer, Jan Till, Tushar Salukhe, Sanjay K Prasad, Piers E F Daubeney
OBJECTIVE: Ivabradine is a selective and specific inhibitor of the I(f) current in the sinoatrial and atrioventricular nodes. It decreases heart rate and myocardial oxygen consumption at rest and during exercise. It is used in adults for management of heart failure and angina, but promising results have been obtained in postural orthostatic tachycardia syndrome (POTS). There is little experience of ivabradine in childhood, although it is used on a compassionate basis. Our aim was to review our experience of ivabradine in a retrospective evaluation of pediatric patients with POTS...
October 13, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29024579/impact-of-the-norepinephrine-prodrug-droxidopa-on-the-qtc-interval-in-healthy-individuals
#6
William B White, L Arthur Hewitt, Ali A Mehdirad
A double-blind, 4-period crossover study (NCT01327066) was conducted to assess the effect of the novel norepinephrine prodrug droxidopa on the QT interval in in healthy subjects. Subjects were randomized to receive a single dose of droxidopa 600 mg (maximal dose) and 2000 mg (supratherapeutic dose) compared with the positive control, moxifloxacin 400 mg, and placebo, each separated by a 3-day washout period. Patients were monitored by continuous Holter monitoring, and electrocardiograms (ECGs) were extracted 0...
October 11, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29022989/prophylactic-intravenous-calcium-therapy-for-exchange-blood-transfusion-in-the-newborn
#7
REVIEW
Tinuade A Ogunlesi, Foluso Ea Lesi, Olabisi Oduwole
BACKGROUND: Exchange blood transfusion (EBT) is a form of whole blood transfusion in which the total blood volume is replaced within a few hours. In perinatal and neonatal medicine, EBT is most often used in the management of severe anaemia or severe hyperbilirubinaemia in the first week of life. Hypocalcaemia, one of the common morbidities associated with EBT, is thought to arise from the chelating effects of the citrate commonly used as an anticoagulant in the donor's blood. This disorder manifests with muscular and nervous irritability and cardiac arrhythmias...
October 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29021866/criteria-for-short-qt-interval-based-on-a-new-qt-heart-rate-adjustment-formula
#8
Simon W Rabkin
BACKGROUND: A short QT interval, within which an increased risk for atrial fibrillation and/or fatal cardiac arrhythmias occurs, has been difficult to define. METHODS: The lower percentiles of a new QTc formula were determined, using a precise mathematical fitting of the QT-heart rate relationship from the ECGs of 13,600 individuals from the NHANES II and III surveys. RESULTS: The QTc interval for persons in the lower fifth percentile, second (2...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29017839/qtc-prolongation-during-phenol-croton-oil-peels
#9
Carlos Gustavo Wambier, Sarah Perillo de Farias Wambier, Liliana Elias Pena Pilatti, Jessica Adriana Grabicoski, Luis Fernando Wambier, André Schmidt
No abstract text is available yet for this article.
October 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29016797/multiple-clinical-profiles-of-families-with-the-short-qt-syndrome
#10
D Akdis, A M Saguner, A Medeiros-Domingo, A Schaller, C Balmer, J Steffel, C Brunckhorst, F Duru
Aims: Short QT syndrome (SQTS) is a rare cardiac channelopathy characterized by a shortened corrected QT (QTc)-interval that can lead to ventricular arrhythmias and sudden cardiac death. The aim of this study was to investigate the clinical phenotypes and long-term outcomes of three families harbouring genetic mutations associated with the SQTS. Methods and results: Clinical data included medical history, physical examination, 12-lead ECG, 24-h Holter-ECG, and transthoracic echocardiography from three index patients and their first-degree relatives...
July 19, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28994902/corrected-qt-interval-and-methadone-dose-and-concentrations-in-pregnant-and-postpartum-women
#11
Debra L Bogen, Barbara H Hanusa, James M Perel, Frederick Sherman, Marla A Mendelson, Katherine L Wisner
BACKGROUND: Methadone is a standard treatment for opioid dependence in pregnancy; however, its impact on maternal corrected QT interval (QTc) has not been evaluated. We studied the association between methadone dose and enantiomer-specific plasma concentrations and QTc among pregnant and postpartum women and newborns. We assessed the relevance of QTc screening guidelines for pregnant women and infants. METHODS: From 2006 to 2008, plasma methadone concentrations were measured during pregnancy, postpartum, and in cord blood in women treated for opioid dependence at a single treatment program...
September 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28993731/small-and-intermediate-calcium-activated-potassium-channel-openers-improve-rat-endothelial-and-erectile-function
#12
Simon G Comerma-Steffensen, Ingrid Carvacho, Elise R Hedegaard, Ulf Simonsen
Modulation of endothelial calcium-activated potassium (KCa) channels has been proposed as an approach to restore endothelial function. The present study investigated whether novel openers of KCa channels with small (KCa2.x) and intermediate (KCa3.1) conductance, NS309 and NS4591, improve endothelium-dependent relaxation and erectile function. Rat corpus cavernosum (CC) strips were mounted for isometric tension recording and processed for immunoblotting. Mean arterial pressure (MAP), intracavernosal pressure (ICP), and electrocardiographic (ECG) measurements were conducted in anesthetized rats...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28992960/tp-e-interval-and-tp-e-qt-ratio-in-patients-with-celiac-disease
#13
K Demirtaş, Ç Yayla, M Yüksel, B Açar, S Ünal, A G Ertem, M Kaplan, M Y Akpinar, Z M Y Kiliç, E Kayaçetin
OBJECTIVES: Celiac disease is a chronic immune-mediated disease of the small intestine. It has been known that dilated cardiomyopathy and ischemic coronary artery disease have become more frequent in patients with celiac disease. The aim of the study was to assess Tp-e interval and Tp-e/QT ratio in patients with celiac disease. MATERIAL AND METHODS: This study was conducted at a single center in collaboration with gastroenterology and cardiology clinics. Between January 2014 and June 2015, a total of 76 consecutive patients were enrolled (38 patients with celiac disease and 38 control subjects)...
October 7, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28989880/arrhythmias-in-type-2-diabetes-mellitus
#14
Gaurav Agarwal, Satish Kumar Singh
Chronic hyperglycaemia of Type 2 diabetes mellitus causes long term damage to heart resulting in coronary artery disease (CAD), myocardial infarction (MI), congestive heart failure (CHF), and sudden death from arrhythmias. AIMS: To study the prevalence of different types of arrhythmias in T2DM, particularly in association with Cardiac Autonomic Neuropathy (CAN). METHODS: A cross-sectional study including 100 patients of Type 2 Diabetes Mellitus (T2DM) presenting with cardiac arrhythmias, was done at our hospital over 2 years...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28986454/validation-of-polygenic-scores-for-qt-interval-in-clinical-populations
#15
Michael A Rosenberg, Steven A Lubitz, Honghuang Lin, Gulum Kosova, Victor M Castro, Paul Huang, Patrick T Ellinor, Roy H Perlis, Christopher Newton-Cheh
BACKGROUND: Polygenic risk scores (PGS) enable rapid estimation of genome-wide susceptibility for traits, which may be useful in clinical settings, such as prediction of QT interval. In this study, we sought to validate PGS for QT interval in 2 real-world cohorts of European ancestry (EA) and African ancestry (AA). METHODS AND RESULTS: Two thousand nine hundred and fifteen participants of EA and 366 of AA in the MGH CAMP study (Cardiology and Metabolic Patient) were genotyped on a genome-wide array and imputed to the 1000 Genomes reference panel...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28984702/current-assessment-of-heart-rate-variability-and-qtc-interval-length-in-hiv-aids
#16
Roger C McIntosh, Judith D Lobo, Barry E Hurwitz
PURPOSE OF REVIEW: The increasing prevalence of cardiovascular disease comorbidity in persons infected with the HIV has become a global concern. The electrocardiogram (ECG) is increasingly being utilized to provide clinically relevant information regarding cardiac arrhythmias and cardio-autonomic dysfunction. The purpose of this review is to summarize the latest research comparing QT and R-to-R interval length as a function of HIV+ status or antiretroviral therapy (ART) regimen. RECENT FINDINGS: Prolongation of the corrected QTc interval may be acquired in HIV+ ART-naive individuals, exacerbated by various classes of ART drugs, and is generally predictive of lethal cardiac arrhythmias, with effects observed from childhood to adulthood...
November 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28979725/effect-of-nicorandil-on-qt-dispersion-in-patients-with-stable-angina-pectoris-undergoing-elective-angioplasty-a-triple-blind-randomized-placebo-controlled-study
#17
Homa Fal Suleimani, Ali Eshraghi, Mehdi Hasanzadeh Daloee, Sara Hoseini, Nima Nakhaee
BACKGROUND: Nicorandil leads to the relaxation of fine vascular smooth muscle, and thus causes vasodilatation of major epicardial. Also, it has anti-arrhythmic and cardio-protective effects by improving reperfusion, and ultimately leads to a reduction in microvascular damage caused by percutaneous coronary intervention (PCI). OBJECTIVE: The aim of this study was to determine the effect of nicorandil on QT interval dispersion (QTd) in patients with stable angina pectoris during elective angioplasty...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28974832/qtc-interval-prolongation-and-hemorrhagic-stroke-any-difference-between-acute-spontaneous-intracerebral-hemorrhage-and-acute-non-traumatic-subarachnoid-hemorrhage
#18
Osama Shukir Muhammed Amin, Sarwer Jamal Al-Bajalan, Alaa Mubarak
BACKGROUND: A variety of ECG changes occur as an aftermath of stroke. Prolongation of the QTc interval is a well-documented change. We analyzed QTc interval prolongation among patients with acute hemorrhagic strokes. METHODS: This observational study was conducted at the Emergency Department of Sulaymaniyah General Teaching Hospital and Shar Hospital from September 1(st), 2014 to August 31(st), 2015. Fifty patients who developed acute spontaneous hypertensive intracerebral hemorrhage (ICH) and 50 patients who developed acute non-traumatic subarachnoid hemorrhage (SAH) were included in the study...
June 2017: Medical Archives
https://www.readbyqxmd.com/read/28974521/update-to-practice-standards-for-electrocardiographic-monitoring-in-hospital-settings-a-scientific-statement-from-the-american-heart-association
#19
REVIEW
Kristin E Sandau, Marjorie Funk, Andrew Auerbach, Gregory W Barsness, Kay Blum, Maria Cvach, Rachel Lampert, Jeanine L May, George M McDaniel, Marco V Perez, Sue Sendelbach, Claire E Sommargren, Paul J Wang
BACKGROUND AND PURPOSE: This scientific statement provides an interprofessional, comprehensive review of evidence and recommendations for indications, duration, and implementation of continuous electro cardiographic monitoring of hospitalized patients. Since the original practice standards were published in 2004, new issues have emerged that need to be addressed: overuse of arrhythmia monitoring among a variety of patient populations, appropriate use of ischemia and QT-interval monitoring among select populations, alarm management, and documentation in electronic health records...
October 3, 2017: Circulation
https://www.readbyqxmd.com/read/28974519/delayed-repolarization-underlies-ventricular-arrhythmias-in-rats-with-heart-failure-and-preserved-ejection-fraction
#20
Jae Hyung Cho, Rui Zhang, Peter J Kilfoil, Romain Gallet, Geoffrey de Couto, Catherine Bresee, Joshua I Goldhaber, Eduardo Marbán, Eugenio Cingolani
Background -Heart failure with preserved ejection fraction (HFpEF) represents approximately half of heart failure, and its incidence continues to increase. The leading cause of mortality in HFpEF is sudden death, but little is known about the underlying mechanisms. Methods -Dahl salt-sensitive rats were fed a high-salt diet (8% NaCl) from 7 weeks of age to induce HFpEF (n=38). Rats fed a normal-salt diet (0.3% NaCl) served as controls (n=13). Echocardiograms were performed to assess systolic and diastolic function from 14 weeks of age...
October 3, 2017: Circulation
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