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https://www.readbyqxmd.com/read/28545487/inhaled-ambient-level-traffic-derived-particulates-decrease-cardiac-vagal-influence-and-baroreflexes-and-increase-arrhythmia-in-a-rat-model-of-metabolic-syndrome
#1
Alex P Carll, Samir M Crespo, Mauricio S Filho, Douglas H Zati, Brent A Coull, Edgar A Diaz, Rodrigo D Raimundo, Thomas N G Jaeger, Ana Laura Ricci-Vitor, Vasileios Papapostolou, Joy E Lawrence, David M Garner, Brigham S Perry, Jack R Harkema, John J Godleski
BACKGROUND: Epidemiological studies have linked exposures to ambient fine particulate matter (PM2.5) and traffic with autonomic nervous system imbalance (ANS) and cardiac pathophysiology, especially in individuals with preexisting disease. It is unclear whether metabolic syndrome (MetS) increases susceptibility to the effects of PM2.5. We hypothesized that exposure to traffic-derived primary and secondary organic aerosols (P + SOA) at ambient levels would cause autonomic and cardiovascular dysfunction in rats exhibiting features of MetS...
May 25, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28543601/influence-of-meals-and-glycemic-changes-on-qt-interval-dynamics
#2
Brenda Cirincione, Philip T Sager, Donald E Mager
Thorough QT/QTc studies have become an integral part of early drug development programs, with major clinical and regulatory implications. This analysis expands on existing pharmacodynamic models of QT interval analysis by incorporating the influence of glycemic changes on the QT interval in a semimechanistic manner. A total of 21 healthy subjects enrolled in an open-label phase 1 pilot study and provided continuous electrocardiogram monitoring and plasma glucose and insulin concentrations associated with a 24-hour baseline assessment...
May 22, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28542844/the-inward-rectifier-current-inhibitor-pa-6-terminates-atrial-fibrillation-and-does-not-cause-ventricular-arrhythmias-in-dedicated-goat-and-dog-models
#3
Yuan Ji, Rosanne Varkevisser, Dragan Opacic, Alexandre Bossu, Marion Kuiper, Jet D M Beekman, Sihyung Yang, Azinwi Phina Khan, Dobromir Dobrev, Niels Voigt, Michael Zhuo Wang, Sander Verheule, Marc A Vos, Marcel A G Van der Heyden
BACKGROUND AND PURPOSE: Inward rectifier current (IK1 ) density increases in atrial fibrillation (AF), shortening effective refractory period and thus promotes atrial reentry. Pentamidine-Analogue 6 (PA-6) is a selective and potent IK1 inhibitor. We tested PA-6 for anti-AF efficacy and potential proarrhythmia, in established large animal models. EXPERIMENTAL APPROACH: PA-6 was applied i.v. in anaesthetized goats with rapid pacing induced AF and anaesthetized chronic AV block dogs...
May 24, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28538401/atrial-fibrillation-was-changed-into-sinus-bradycardia-in-a-ros1-positive-advanced-lung-adenocarcinoma-patient-who-achieved-durable-response-to-crizotinib-a-case-report-and-literature-review
#4
Lan Liu, Jing Wu, Wei Zhao, Mei-Juan Huang
RATIONAL: The c-ros oncogene 1 receptor tyrosine kinase (ROS1)-rearrangements represent a new and rare genetic subtype of non-small-cell lung cancer. In recent years, the use of crizotinib in ROS1-rearranged lung cancer exhibits significant clinical efficacy. Crizotinib is generally well tolerated and the most frequent adverse events include visual disorders, gastrointestinal disturbances, cardiac, and endocrine abnormalities. From a cardiac perspective, crizotinib is associated with 2 main cardiac effects, QT interval prolongation and bradycardia...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28535735/clenbuterol-attenuates-herg-channel-by-promoting-the-mature-channel-degradation
#5
Ling Luo, Peijing Hu, Changqing Miao, Aiqun Ma, Tingzhong Wang
Clenbuterol, a β2-selective adrenergic receptor agonist, is illicitly used in weight loss and performance enhancement and animal production. Increasing evidence demonstrates that clenbuterol induces various kinds of arrhythmias and QTc interval prolongation. However, little is known about the underlying mechanism. Most drugs are associated with QTc prolongation through interfering with human ether-a-go-go-related gene (hERG) K(+) channels. The present study aims to investigate the effects and underlying mechanisms of clenbuterol on the hERG channel...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28513513/electrocardiographic-changes-and-troponin-t-levels-in-children-with-severe-malaria-anemia-and-heart-failure
#6
W E Sadoh, J O Uduebor
BACKGROUND: Severe malaria anemia is a major cause of childhood heart failure in malaria endemic countries. The resulting hypoxic-ischemic injuries may cause myocardial damage detectable by electrocardiogram (ECG) and elevated troponin T (cTnT) levels. OBJECTIVE: Evaluate the ECG changes and cTnT levels in children with severe malaria anemia compared with those who had uncomplicated malaria without anemia. METHODS: Consecutive children with severe malaria anemia were recruited as subjects while controls were age- and gender-matched children with uncomplicated malaria without anemia...
May 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28512721/mid-term-risk-for-subclinical-atherosclerosis-and-chronic-myocarditis-in-children-with-kawasaki-disease-and-transient-coronary-abnormalities
#7
Mansingh Parihar, Surjit Singh, Pandiarajan Vignesh, Anju Gupta, Manojkumar Rohit
There is evidence for premature atherosclerosis and systemic arterial stiffening during follow-up of children with Kawasaki disease (KD) and coronary artery abnormalities (CAA). Moreover, patients with KD may also have subclinical myocardial involvement and inhomogeneous ventricular repolarization. The inhomogeneous ventricular repolarization manifests as increased QT dispersion on electrocardiography. There is a paucity of studies in endothelial dysfunction and QT dispersion in children with KD and transient CAA...
May 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28511997/thorough-qt-tqt-studies-concordance-with-torsadogenesis-and-an-evolving-cardiac-safety-testing-paradigm
#8
Barbara Wiśniowska, Zofia Tylutki, Sebastian Polak
Since 2005, when the International Conference on Harmonisation (ICH) E14 guideline was adopted, no drug has been withdrawn because of QTc prolongation or torsade de pointes arrhythmia. There are, however, costs associated with this success. In addition to the time and money invested, thorough QT (TQT) studies have limited the efficiency of the drug development pipeline. In this paper, we discuss the relevance of TQT trials as a tool for proarrhythmic risk prediction as a part of the debate regarding their usefulness...
May 13, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28510787/a-phase-ii-trial-of-arsenic-trioxide-and-temozolomide-in-combination-with-radiation-therapy-for-patients-with-malignant-gliomas
#9
Priya Kumthekar, Sean Grimm, James Chandler, Minesh Mehta, Maryanne Marymont, Robert Levy, Kenji Muro, Irene Helenowski, Katie McCarthy, Leanne Fountas, Jeffrey Raizer
Standard treatment for GBM is radiation (RT) and temozolomide (TMZ). Arsenic trioxide (ATO) is synergistic with RT based on several mechanisms of action previously identified, however not tested herein. The MTD of ATO, RT and TMZ was determined in a Phase I trial. We now present the combined Phase I/II data. Patients with newly diagnosed malignant gliomas were eligible for treatment. Patients were treated with RT (60 GY), TMZ (75 mg/m(2) daily × 42 days) and ATO 0.20 mg/kg daily in week 1 then twice a week ×5 weeks, after completing RT they were treated with TMZ 5/28 for up to 12 months...
May 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28510346/lack-of-effect-of-rivipansel-on-qtc-interval-in-healthy-adult-african-american-male-subjects
#10
Brinda K Tammara, Anna Plotka, Frank E Shafer, David R J Readett, Steve Riley, Joan M Korth-Bradley
Rivipansel is a pan-selectin inhibitor in phase 3 development for the treatment of vaso-occlusive crises in patients with sickle cell disease. This single-dose, randomized, 3-period, 3-treatment (400 mg moxifloxacin open-label, 4 g rivipansel-blinded, and placebo-blinded) crossover study evaluated the effect of rivipansel on the QT/QTc interval in 48 healthy male African American subjects (age, 21-53 years; weight, 60-115 kg). Time-matched, placebo-adjusted change from baseline QT interval using Fridericia's correction method (QTcF) was determined using a repeated-measures mixed-effects model...
May 16, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28509573/adverse-events-of-atomoxetine-in-a-double-blind-placebo-controlled-study-in-children-with-autism
#11
Rameshwari V Tumuluru, Patricia Corbett-Dick, Michael G Aman, Tristram Smith, L Eugene Arnold, Xueliang Pan, Kristin A Buchan-Page, Nicole V Brown, Melissa M Ryan, Susan L Hyman, Jessica Hellings, Craig Williams, Jill A Hollway, Luc Lecavalier, Robert R Rice, Sarah McAuliffe-Bellin, Benjamin L Handen
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) symptoms, including inattention and over activity, occur in approximately one-third of children with autism spectrum disorder (ASD). We describe the rate and duration of adverse events in a randomized controlled trial of atomoxetine (ATX) and parent training (PT) for ADHD symptoms and noncompliance in children with ASD. METHODS: We conducted a 10-week, double-blind, 2 × 2 trial of ATX and PT with 128 children (ages 5-14) randomized to ATX alone, ATX+PT, placebo+PT, or placebo alone...
May 16, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28508456/age-and-sex-based-reference-ranges-for-non-invasive-ventricular-repolarisation-parameters
#12
Annabella Braschi, Maurizio G Abrignani, Vincenzo C Francavilla, Vincenzo Abrignani, Giuseppe Francavilla
BACKGROUND: Some electrocardiographic parameters are able to assess indirectly ventricular repolarisation homogeneity. It is consequently essential to discriminate between normal and abnormal values in clinical decision-making. Considering there is still not a consensus about normal cut-off values, the aim of this study was to document reference intervals in all age groups of a healthy population, providing for age- and sex-percentile tables, which can be used easily and quickly in clinical practice...
May 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28507628/does-vitamin-d-deficiency-effect-heart-rate-variability-in-low-cardiovascular-risk-population
#13
Ahmet Nalbant, Mehmet Bulent Vatan, Perihan Varım, Ceyhun Varım, Tezcan Kaya, Ali Tamer
AIM: This study aimed to evaluate the cardiac autonomic dysfunction and the cardiac arrhythmia risk using heart rate variability parameters in subjects with vitamin D deficiency and low cardiovascular risk. MATERIAL AND METHODS: One hundred five consecutive individuals, 54 patients with low vitamin D status and 51 healthy controls were enrolled in this study. The overall cardiac autonomic tone was quantified by using various heart rate variability parameters included mean RR interval, mean Heart Rate, mean of standard deviations of intervals for 24 hours (SDNN), standard deviation of averages of intervals (SDANN), mean of standard deviation of intervals for 5 minutes (SDNNI), root mean square of difference of successive intervals (rMSSD) and the proportion of intervals differing more than 50 ms (pNN50) values...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28502326/k-and-mg-2-dyshomeostasis-in-acute-hyperadrenergic-stressor-states
#14
Mannu Nayyar, Jawwad Yusuf, M Usman Khan, Karl T Weber
Acute stressor states are linked to neurohormonal activation that includes the adrenergic nervous system. Elevations in circulating epinephrine and norepinephrine unmask an interdependency that exists between K(+) and Mg(2+) based on their regulation of a large number of Mg(2+)-dependent Na(+)-K(+)-ATPase pumps present in skeletal muscle. The hyperadrenergic state accounts for a sudden translocation of cations into muscle with the rapid appearance of hypokalemia and hypomagnesemia. The resultant hypokalemia and hypomagnesemia will cause a delay in myocardial repolarization and electrocardiographic QTc prolongation raising the propensity for supraventricular and ventricular arrhythmias...
May 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28497941/antiarrhythmic-effects-of-ranolazine-used-both-alone-for-prevention-of-atrial-fibrillation-and-as-an-add-on-to-intravenous-amiodarone-for-its-pharmacological-cardioversion-a-meta-analysis
#15
Renato DE Vecchis, Carmelina Ariano, Anna Giasi, Carmela Cioppa
BACKGROUND: Recent evidence from relatively small randomized controlled trials would seem to support a useful role of ranolazine for the prevention and treatment of atrial fibrillation (AF). The present study is aimed at providing information about the possible beneficial anti-arrhythmic properties of ranolazine. In particular, the meta-analysis carried out in this study focuses on the application of ranolazine to prophylaxis and treatment of atrial fibrillation. METHODS: Both randomized controlled trials (RCTs) and non randomized observational studies concerning the effects of ranolazine on AF were included in the meta-analysis...
May 10, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28496926/novel-ventricular-repolarization-indices-in-patients-with-coronary-slow-flow
#16
Murat Sucu, Berzal Ucaman, Orhan Ozer, Yakup Altas, Esra Polat
Background: Coronary slow flow (CSF) phenomenon is described angiographically as delayed progression of the injected contrast agents through the coronary arteries. Aim of this study was to analyze ventricular repolarization in CSF patients by using Tpeak-Tend interval, Tpeak-Tend/QT ratio, Tpeak-Tend/QTc ratio and other repolarization parameters since these parameters are used as predictors for ventricular arrhythmogenesis. Materials and Methods: We have retrospectively analyzed diagnostic coronary angiography results of 160 patients between 2010 and 2014...
October 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/28495651/percentile-categorization-of-qt-interval-as-an-approach-for-identifying-adult-patients-at-risk-for-cardiovascular-death
#17
Reza Mohebi, Ayesha Jehan, Aaron Grober, Victor Froelicher
BACKGROUND: The results from studies of the association of QT prolongation with CVD have been inconsistent. OBJECTIVES: To compare the major correction formulas to percentile values of QT for heart rate ranges as to their ability to remove the relationship of QT to heart rate and to predict cardiovascular death(CVD). METHODS: Participants were 16,531 veterans who had an initial ECG at the Veterans Affairs Medical Center, Palo Alto between March 31, 1987, and December 20, 1999 and were followed for CVD...
May 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28490617/systemic-inflammation-as-a-novel-qt-prolonging-risk-factor-in-patients-with-torsades-de-pointes
#18
Pietro Enea Lazzerini, Franco Laghi-Pasini, Iacopo Bertolozzi, Gabriella Morozzi, Sauro Lorenzini, Antonella Simpatico, Enrico Selvi, Maria Romana Bacarelli, Francesco Finizola, Francesca Vanni, Deana Lazaro, Ademuyiwa Aromolaran, Nabil El Sherif, Mohamed Boutjdir, Pier Leopoldo Capecchi
OBJECTIVE: Increasing evidence indicates systemic inflammation as a new potential cause of acquired long QT syndrome (LQTS), via cytokine-mediated changes in cardiomyocyte ion channels. Torsade de pointes (TdP) is a life-threatening polymorphic ventricular tachycardia occurring in patients with LQTS, usually when multiple QT-prolonging factors are simultaneously present. Since classical risk factors cannot fully explain TdP events in a number of patients, we hypothesised that systemic inflammation may represent a currently overlooked risk factor contributing to TdP development in the general population...
May 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28489458/toxicokinetics-of-ibogaine-and-noribogaine-in-a-patient-with-prolonged-multiple-cardiac-arrhythmias-after-ingestion-of-internet-purchased-ibogaine
#19
Marieke Henstra, Liza Wong, Abdel Chahbouni, Noortje Swart, Cor Allaart, Ferdi Sombogaard
BACKGROUND: Ibogaine is an agent that has been evaluated as an unapproved anti-addictive agent for the management of drug dependence. Sudden cardiac death has been described to occur secondary to its use. We describe the clinical effects and toxicokinetics of ibogaine and noribogaine in a single patient. For this purpose, we developed a LC-MS/MS-method to measure ibogaine and noribogaine plasma-concentrations. We used two compartments with first order absorption. CASE DETAILS: The maximum concentration of ibogaine was 1...
July 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28487061/the-spectrum-of-ambulatory-electrocardiographic-monitoring
#20
REVIEW
Harry G Mond
Since its introduction as a clinical investigative tool, the 12-lead electrocardiograph (ECG) has been the gold standard for recognition of cardiac arrhythmias. The resting 12-lead ECG, however, gives only a rhythm snapshot in time, whereas arrhythmias maybe short-lived, paroxysmal and even asymptomatic making documentation in many patients very difficult. To overcome this, ambulatory ECG monitoring has been developed as a means of recording the ECG in patients over a set period of time, whether it be short-, medium- or long-term...
April 13, 2017: Heart, Lung & Circulation
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