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Opisthorchis viverrini

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https://www.readbyqxmd.com/read/27927864/efficacy-and-safety-of-praziquantel-against-light-infections-of-opisthorchis-viverrini-a-randomised-parallel-single-blind-dose-ranging-trial
#1
Somphou Sayasone, Isabel Meister, Jason R Andrews, Peter Odermatt, Youthanavanh Vonghachack, Syda Xayavong, Kanpaseuth Senggnam, Khampheng Phongluxa, Jan Hattendorf, Isaac I Bogoch, Jennifer Keiser
BACKGROUND: The liver fluke Opisthorchis viverrini, highly prevalent in Southeast Asia, is an important public health burden, including a risk factor for developing an aggressive bile duct cancer, cholangiocarcinoma, in chronically infected patients. Praziquantel, administered at single 40 mg/kg in preventive chemotherapy programs and 3 x 25 mg/kg for individual treatment is the drug of choice, yet information on the nature of the dose-response relationship is lacking. METHODS: We performed a randomized, parallel, single blind dose-ranging Phase 2 trial in Lao PDR in O...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27926938/uncovering-the-pathogenic-landscape-of-helminth-opisthorchis-viverrini-infections-a-cross-sectional-study-on-contributions-of-physical-and-social-environment-and-healthcare-interventions
#2
Xueyuan Ong, Yi-Chen Wang, Paiboon Sithithaworn, Jutamas Namsanor, David Taylor, Luxana Laithavewat
BACKGROUND: Helminth infections have proven recalcitrant to control by chemotherapy in many parts of Southeast Asia and indeed farther afield. This study isolates and examines the influence of different aspects of the physical and social environment, and uneven intervention effort contributing to the pathogenic landscape of human Opisthorchis viverrini infections. METHODOLOGY: A cross-sectional survey, involving 632 participants, was conducted in four villages in northeast Thailand to examine the impact on prevalence and parasite burden of the reservoir dam environment, socio-economic, demographic, and behavioral factors, and health center intervention efforts...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27919744/co-infections-with-liver-fluke-and-helicobacter-species-a-paradigm-change-in-pathogenesis-of-opisthorchiasis-and-cholangiocarcinoma
#3
REVIEW
Banchob Sripa, Raksawan Deenonpoe, Paul J Brindley
Infection with the fish-borne liver fluke Opisthorchis viverrini is classified by the International Agency for Research on Cancer as a Group 1 carcinogen: definitely carcinogenic in humans. Cofactors likely contribute to bile duct cancer (cholangiocarcinoma) caused by this infection. Here we review recent findings that address the role of liver fluke associated H. pylori in hepatobiliary disease and malignancy. We hypothesize that co-infection by O. viverrini and the bacillus Helicobacter pylori is central of liver fluke infection associated cholangiocarcinoma...
December 2, 2016: Parasitology International
https://www.readbyqxmd.com/read/27893749/differential-protein-expression-in-the-hemolymph-of-bithynia-siamensis-goniomphalos-infected-with-opisthorchis-viverrini
#4
Kulwadee Suwannatrai, Apiporn Suwannatrai, Pairat Tabsripair, Jariya Umka Welbat, Sirikachorn Tangkawattana, Cinzia Cantacessi, Jason Mulvenna, Smarn Tesana, Alex Loukas, Javier Sotillo
Bithynia siamensis goniomphalos is a freshwater snail that serves as the first intermediate host of the human liver fluke Opisthorchis viverrini. This parasite is a major public health problem in different countries throughout the Greater Mekong sub-region (Thailand, southern Vietnam, Lao PDR and Cambodia). Chronic O. viverrini infection also results in a gradual increase of fibrotic tissues in the biliary tract that are associated with hepatobiliary diseases and contribute to cholangiocarcinoma (a fatal type of bile duct cancer)...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27890720/the-lawa-model-a-sustainable-integrated-opisthorchiasis-control-program-using-the-ecohealth-approach-in-the-lawa-lake-region-of-thailand
#5
Banchob Sripa, Sirikachorn Tangkawattana, Thinnakorn Sangnikul
Opisthorchiasis caused by the carcinogenic liver fluke Opisthorchis viverrini is a major foodborne parasitic zoonotic disease in Thailand and neighboring Mekong countries. The infection is associated with several hepatobiliary diseases including cholangiocarcinoma (CCA). The rates of CCA in regions where the parasite is endemic are unprecedented. Extensive research on various aspects of opisthorchiasis has been conducted in recent decades. However, the current status of O. viverrini infection in the country is approaching 85% prevalence in certain endemic areas even after more than 30years of control programs in Thailand...
November 24, 2016: Parasitology International
https://www.readbyqxmd.com/read/27882434/new-locality-record-for-haplorchoides-mehrai-and-possible-interactions-with-opisthorchis-viverrini-metacercariae-in-cyprinid-fishes-in-northeast-thailand
#6
Yupin Manpratum, Wanlop Kaewkes, Pierre Echaubard, Banchob Sripa, Sasithorn Kaewkes
Metacercariae of Opisthorchis viverrini, a carcinogenic liver fluke, and Haplorchoides sp., a trematode maturing in catfish, are commonly found in cyprinid fish, the second intermediate hosts of both flukes. However, the specific identity of Haplorchoides sp. in Thailand and a precise assessment of the effects of co-infections with O. viverrini have never been clarified. Therefore, we aimed to identify the species of Haplorchoides and to investigate possible interactions of the two trematode species in cyprinid fishes...
November 23, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27880787/seasonal-and-spatial-environmental-influence-on-opisthorchis-viverrini-intermediate-hosts-abundance-and-distribution-insights-on-transmission-dynamics-and-sustainable-control
#7
Christina Sunyoung Kim, Pierre Echaubard, Apiporn Suwannatrai, Sasithorn Kaewkes, Bruce A Wilcox, Banchob Sripa
BACKGROUND: Opisthorchis viverrini (Ov) is a complex-life-cycle trematode affecting 10 million people in SEA (Southeast Asia). Human infection occurs when infected cyprinid fish are consumed raw or undercooked. Ov requires three hosts and presents two free-living parasitic stages. As a consequence Ov transmission and infection in intermediate and human hosts are strongly mediated by environmental factors and understanding how environmental variability influences intermediate host abundance is critical...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27821695/development-of-a-pcr-assay-for-diagnosing-trematode-opisthorchis-and-haplorchis-infections-in-human-stools
#8
Pheophet Lamaningao, Seiji Kanda, Sakhone Laimanivong, Takaki Shimono, Andrew Waleluma Darcy, Amphay Phyaluanglath, Nobuyuki Mishima, Toshimasa Nishiyama
We developed a combined conventional polymerase chain reaction (PCR) and real-time PCR (qPCR)-based assay for detecting and discriminating between Opisthorchis viverrini and Haplorchis taichui parasite infections. The first PCR amplifies the mitochondrial cytochrome c oxidase subunit I (COI) genes of parasites, and differential diagnosis is achieved by performing qPCR with specific primers and SYBR Green I. The detection limit of the assay was found to be 2.0 × 10(2) plasmid copies in a test in which a stool sample was spiked with a single egg, which is equivalent to 5 eggs per gram (EPG)...
November 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27806126/chronic-opisthorchis-viverrini-infection-changes-the-liver-microbiome-and-promotes-helicobacter-growth
#9
Upsornsawan Itthitaetrakool, Porntip Pinlaor, Somchai Pinlaor, Chariya Chomvarin, Rungtiwa Dangtakot, Apisit Chaidee, Chotechana Wilailuckana, Arunnee Sangka, Aroonlug Lulitanond, Puangrat Yongvanit
Adults of Opisthorchis viverrini reside in the biliary system, inducing inflammation of bile ducts and cholangitis, leading to hepatobiliary disease (HBD) including cholangiocarcinoma. O. viverrini infection also has major implications for the bacterial community in bile ducts and liver. To investigate this in chronic O. viverrini infection (≥ 8 months p.i.), bacterial genomic DNA from livers of hamsters and from worms was investigated using culture techniques, PCR for Helicobacter spp. and high-throughput next-generation sequencing targeting the V3-V4 hypervariable regions of prokaryotic 16S rRNA gene...
2016: PloS One
https://www.readbyqxmd.com/read/27794488/changing-patterns-of-prevalence-in-opisthorchis-viverrini-sensu-lato-infection-in-children-and-adolescents-in-northeast-thailand
#10
Narong Khuntikeo, Paiboon Sithithaworn, Watcharin Loilom, Nisana Namwat, Puangrat Yongvanit, Bandit Thinkhamrop, Nadda Kiatsopit, Ross H Andrews, Trevor N Petney
Infection with the liver fluke Opisthorchis viverrini sensu lato (s.l.), a group 1 carcinogen, is the most important risk factor for developing cholangiocarcinoma (CCA) in Southeast Asia. Cholangiocarcinoma is a fatal disease with the world's highest incidence being found in northeast Thailand. Liver fluke infection occurs through eating raw or partially cooked cyprinid fish containing metacercariae and, therefore, the control of O. viverrini s.l. infection should lead to a reduction in CCA incidence. In this report, we review and analyze the age-prevalence profile data of O...
October 26, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27774575/modeling-impacts-of-climate-change-on-the-potential-distribution-of-the-carcinogenic-liver-fluke-opisthorchis-viverrini-in-thailand
#11
A Suwannatrai, K Pratumchart, K Suwannatrai, K Thinkhamrop, J Chaiyos, C S Kim, R Suwanweerakamtorn, T Boonmars, T Wongsaroj, B Sripa
Global climate change is now regarded as imposing a significant threat of enhancing transmission of parasitic diseases. Maximum entropy species distribution modeling (MaxEnt) was used to explore how projected climate change could affect the potential distribution of the carcinogenic liver fluke, Opisthorchis viverrini, in Thailand. A range of climate variables was used: the Hadley Global Environment Model 2-Earth System (HadGEM2-ES) climate change model and also the IPCC scenarios A2a for 2050 and 2070. Occurrence data from surveys conducted in 2009 and 2014 were obtained from the Department of Disease Control, Ministry of Public Health, Thailand...
October 24, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27769807/cytokine-profiles-in-opisthorchis-viverrini-stimulated-peripheral-blood-mononuclear-cells-from-cholangiocarcinoma-patients
#12
Arpa Surapaitoon, Sutas Suttiprapa, Narong Khuntikeo, Chawalit Pairojkul, Banchob Sripa
The carcinogenic liver fluke Opisthorchis viverrini causes chronic inflammation in the bile duct and resulting in unremitting tissue damage that lead to hepatobiliary diseases, including cholangiocarcinoma (CCA). Despite inflammatory cytokine expression having been studied in the animal model, so far no studies have been carried out on cytokines in human CCA cases. Here we report the profile of cytokine production in peripheral blood mononuclear cells (PBMCs) collected from O. viverrini-associated human CCA and uninfected normal controls after stimulation with O...
February 2017: Parasitology International
https://www.readbyqxmd.com/read/27746382/association-between-opisthorchis-viverrini-and-leptospira-spp-infection-in-endemic-northeast-thailand
#13
Chinh Dang Van, Galayanee Doungchawee, Sutas Suttiprapa, Yuji Arimatsu, Sasithorn Kaewkes, Banchob Sripa
Opisthorchiasis caused by Opisthorchis viverrini is an important foodborne trematodiasis in Thailand, Laos and Cambodia. Interestingly, the opisthorchiasis endemic region overlaps with an area of leptospirosis emergence. Here we report an association between opisthorchiasis and leptospirosis in Thailand. Of 280 sera collected from villagers living around the Lawa wetland complex in Khon Kaen province, 199 (71%) were seropositive for leptospirosis by immunochromatography. Individuals with O. viverrini infection had a significantly higher rate of leptospirosis than those without (P=0...
October 13, 2016: Parasitology International
https://www.readbyqxmd.com/read/27737764/cpg-oligodeoxynucleotides-with-crude-parasite-antigens-reduce-worm-recovery-in-opisthorchis-viverrini-infected-hamsters
#14
Chamraj Kaewraemruaen, Rasana W Sermswan, Surasakdi Wongratanacheewin
Opisthorchis viverrini, a human liver fluke, is still an endemic parasitic infection in Thailand and nearly all countries in Southeast Asia. O. viverrini induces a chronic stage of infection in hamsters. During the first 2 weeks of infection, Th1 inducing cytokine, IL-12, increased but was down regulated in chronic infection. In this study it was found that unmethylated-CpG ODN (oligodeoxynucleotides) 1826 increased hamster mononuclear cell proliferation and stimulated IFN-γ production in vitro. The IFN-γ levels in hamster sera were significantly increased in hamsters injected with CpG ODN 1826 alone or plus crude somatic antigens (CSAg)...
October 11, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27718017/liver-fluke-infection-and-cholangiocarcinoma-a-review
#15
Shuohan Zheng, Yuan Zhu, Zijun Zhao, Zhongdao Wu, Kamolnetr Okanurak, Zhiyue Lv
Parasites are significant groups for carcinogenesis among which liver flukes, including Opisthorchis viverrini and Clonorchis sinensis, are typical representatives causing cholangiocarcinoma (CCA), the second most common primary hepatic malignancy with dismal prognosis. O. viverrini is prevalent in Southeast Asia, infecting 10 million people while C. sinensis has a wider distribution in East Asia and several Southeast Asian countries, affecting more than 35 million people's health. These two worms have some common characteristics and/or discrepancies in life cycle, genome, and transcriptome...
October 8, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27666946/health-informatics-model-for-helminthiasis-in-thailand
#16
C Nithikathkul, A Trevanich, T Wongsaroj, C Wongsawad, P Reungsang
At the beginning of the new millennium, helminth infections continue to be prevalent, particularly among impoverished populations. This study attempts to create the first health informatics model of helminthiasis in Thailand. The authors investigate how a health informatics model could be used to predict the control and eradication in a national control campaign. Fish-borne helminthiasis caused by Opisthorchis viverrini remains a major public health problem in many parts of South-East Asia, including Thailand, Lao PDR, Vietnam and Cambodia...
September 26, 2016: Journal of Helminthology
https://www.readbyqxmd.com/read/27644606/modifying-health-behavior-for-liver-fluke-and-cholangiocarcinoma-prevention-with-the-health-belief-model-and-social-support-theory
#17
Natnapa Padchasuwan, Soraya J Kaewpitoon, Ratana Rujirakul, Parichart Wakkuwattapong, Jun Norkaew, Jirawoot Kujapun, Sukanya Ponphimai, Wasugree Chavenkun, Pontip Kompor, Natthawut Kaewpitoon
The liver fluke Opisthorchis viverrini is a serious health problem in Thailand. Infection is associated with cholangiocarcinoma (CCA), endemic among human populations in northeast and north Thailand where raw fish containing fluke metacercariae are frequently consumed. Recently, Thailand public health authorities have been organized to reduce morbidity and mortality particularly in the northeast through O. viverrini and CCA screening projects. Health modfication is one of activities included in this campaign, but systemic guidelines of modifying and developing health behavior for liver flukes and CCA prevention in communities towards health belief and social support theory are still various and unclear...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27576001/efficacious-and-safe-dose-of-praziquantel-for-the-successful-treatment-of-feline-reservoir-hosts-with-opisthorchiasis
#18
Piya Sereerak, Songkaid Upontain, Prasarn Tangkawattana, Frank F Mallory, Banchob Sripa, Sirikachorn Tangkawattana
Opisthorchiasis caused by Opisthorchis viverrini is a major food-borne zoonosis in Greater Mekong sub-region. Even though campaigns discouraging the consumption of raw fish have been launched to public, the disease still remains highly endemic. The unsuccessful eradication of the disease is probably because of the persistence of the parasite in animal reservoir hosts, particularly felids. Praziquantel (PZQ) is the drug of choice for morbidity control of opisthorchiasis in humans and animals. However, there is no specific study on its dosage regimen for feline opisthorchiasis...
August 26, 2016: Parasitology International
https://www.readbyqxmd.com/read/27570099/prevalence-of-gastrointestinal-helminth-parasites-of-zoonotic-significance-in-dogs-and-cats-in-lower-northern-thailand
#19
Wilawan Pumidonming, Doaa Salman, Dulyatad Gronsang, Abdelbaset E Abdelbaset, Khamphon Sangkaeo, Shin-Ichiro Kawazu, Makoto Igarashi
Gastrointestinal zoonotic helminths of dogs and cats have a public health concern worldwide. We investigated the prevalence of gastrointestinal helminths of zoonotic significance in dogs and cats in lower Northern Thailand and utilized molecular tools for species identification of hookworms and Opisthorchis viverrini. Fecal samples of 197 dogs and 180 cats were collected. Overall prevalence of infection using microscopy was 40.1% in dogs and 33.9% in cats. Helminth infection found in both dogs and cats included hookworms, Spirometra spp...
August 27, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27552546/induction-of-regulatory-t-cells-by-opisthorchis-viverrini
#20
C Kaewraemruaen, R W Sermswan, S Wongratanacheewin
Opisthorchis viverrini causes public health problems in South-East Asia. Recently, TGF-β and IL-10 have been reported to increase in O. viverrini-infected hamsters but the sources of these cytokines are still unknown. In this study, the CD4(+) T cells in infected hamsters were investigated. It was demonstrated that IL-4(+) CD4(+) T cells were significantly increased in hamster spleens and mesenteric lymph nodes (MLNs) during chronic infection. Interestingly, IL-10(+) CD4(+) T cells were also discovered at a significant level while Treg (T regulatory)-like TGF- β(+) CD4(+) T cells were in MLNs of infected hamsters...
August 23, 2016: Parasite Immunology
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