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Opisthorchis viverrini

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https://www.readbyqxmd.com/read/29779756/biliary-cystadenoma-associated-with-opisthorchis-viverrini-infection-in-a-domestic-cat-felis-catus
#1
Saruda Tiwananthagorn, Saralee Srivorakul, Varangpicha Khochakul, Kidsadagon Pringproa
A 12-year-old, female, domestic cat (Felis catus) presented with dehydration, emaciation, anorexia, and lethargy. The cat was unresponsive to medical treatment and euthanized; the carcass was submitted for pathological diagnosis. Necropsy revealed icteric mucous membranes. The liver was enlarged, with multinodular, cystic, white masses, 0.5-4.0 cm in diameter, scattered throughout. Microscopically, the biliary epithelium presented with a proliferation of multifocal cystic masses, occasionally with periodic acid-Schiff-positive fluid within the cysts...
May 5, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772240/identification-and-characterization-of-the-zinc-finger-protein-sjzf-in-schistosoma-japonicum
#2
Ruixiang Zhang, Jian Li, Manyu Xiang, Qinghua Hong, Bin Xu, Wei Hu
Schistosomiasis represents one of the most prevalent parasitic infections affecting over 249 million people worldwide. The pathological damage is mainly caused by the eggs laid by female schistosomes. Zinc finger proteins (ZFPs) usually play critical roles in many biological functions. In this study, we cloned, identified and characterized the zinc finger protein SjZF of Schistosoma japonicum. SjZF ortholog proteins were also identified in S. mansoni, S. haematobium, Opisthorchis viverrini and O. sinensis. Fluorescence localization showed that SjZF was particularly expressed in the worm gut of both genders and the vitelline glands of females...
May 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29772216/human-liver-fluke-opisthorchis-viverrini-trematoda-opisthorchiidae-in-central-myanmar-new-records-of-adults-and-metacercariae-identified-by-morphology-and-molecular-analysis
#3
Oranuch Sanpool, Win Pa Pa Aung, Rutchanee Rodpai, Wanchai Maleewong, Pewpan M Intapan
Opisthorchis-like metacercariae were found in cyprinoid fish, Puntius brevis, bought from markets in the Bago region, Central Myanmar. Adult worms recovered from experimentally-infected hamsters resembled Opisthorchis viverrini. DNA was extracted from adults and metacercariae. A portion of the mitochondrial cytochrome c oxidase subunit 1 (cox1) and the internal transcribed spacer 2 (ITS2) regions were amplified using the polymerase chain reaction and then sequenced. The sequences confirmed that the flukes were O...
May 14, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29769113/thinking-beyond-opisthorchis-viverrini-for-risk-of-cholangiocarcinoma-in-the-lower-mekong-region-a-systematic-review-and-meta-analysis
#4
REVIEW
Jennifer A Steele, Carsten H Richter, Pierre Echaubard, Parichat Saenna, Virginia Stout, Paiboon Sithithaworn, Bruce A Wilcox
BACKGROUND: Cholangiocarcinoma (CCA) is a fatal bile duct cancer associated with infection by the liver fluke, Opisthorchis viverrini, in the lower Mekong region. Numerous public health interventions have focused on reducing exposure to O. viverrini, but incidence of CCA in the region remains high. While this may indicate the inefficacy of public health interventions due to complex social and cultural factors, it may further indicate other risk factors or interactions with the parasite are important in pathogenesis of CCA...
May 17, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29727708/artemisinin-and-its-derivatives-in-treating-helminthic-infections-beyond-schistosomiasis
#5
REVIEW
Nelson Siukei Lam, Xinxin Long, Xin-Zhuan Su, Fangli Lu
The World Health Organization estimated that more than 1.5 billion people are infected with soil-transmitted helminths globally, and foodborne trematodiases in humans cause ∼2 million life-years lost to disability and death worldwide every year. Investment in prevention, treatment, and awareness of helminth infections and discovery of new, safe, effective, and affordable anti-helminth drugs are urgently needed. Artemisinin (ART) and its derivatives have been widely used to treat malaria and other protozoan infections; they also possess activities against helminths...
May 1, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29713629/helminths-and-cancers-from-the-evolutionary-perspective
#6
REVIEW
Larissa L S Scholte, Marcelo A Pascoal-Xavier, Laila A Nahum
Helminths include free-living and parasitic Platyhelminthes and Nematoda which infect millions of people worldwide. Some Platyhelminthes species of blood flukes ( Schistosoma haematobium, Schistosoma japonicum , and Schistosoma mansoni ) and liver flukes ( Clonorchis sinensis and Opisthorchis viverrini ) are known to be involved in human cancers. Other helminths are likely to be carcinogenic. Our main goals are to summarize the current knowledge of human cancers caused by Platyhelminthes, point out some helminth and human biomarkers identified so far, and highlight the potential contributions of phylogenetics and molecular evolution to cancer research...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29693152/genistein-reduces-the-activation-of-akt-and-egfr-and-the-production-of-il6-in-cholangiocarcinoma-cells-involving-estrogen-and-estrogen-receptors
#7
Pariyada Tanjak, Apinya Thiantanawat, Piyajit Watcharasit, Jutamaad Satayavivad
Cholangiocarcinoma (CCA) is a malignant tumor of the biliary epithelium associated with Opisthorchis viverrini, primary sclerosing cholangitis and hepatitis viral infection. In the global population, men have higher incidence rates for CCA than women; thus, a gender disparity in the progression of chronic inflammation of the biliary duct leading to malignancy may involve the effects of estrogen (E2). Genistein (GE), a prominent phytoestrogen found in soy products, is an estrogen receptor β (ERβ) agonist and a tyrosine kinase inhibitor...
April 24, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29679744/phylogenetic-relationships-within-the-opisthorchis-viverrini-species-complex-with-specific-analysis-of-o-viverrini-sensu-lato-from-sakon-nakhon-thailand-by-mitochondrial-and-nuclear-dna-sequencing
#8
Opal Pitaksakulrat, Bonnie L Webster, Joanne P Webster, Thewarach Laha, Weerachai Saijuntha, Poppy H L Lamberton, Nadda Kiatsopit, Ross H Andrews, Trevor N Petney, Paiboon Sithithaworn
The liver fluke Opisthorchis viverrini sensu lato causes serious public-health problems in northeast Thailand and Southeast Asian countries. A hypothesis has been proposed that O. viverrini represents a species complex with varying levels of genetic differentiation in Thailand and Lao PDR. This study aimed to clarify whether O. viverrini populations can be genetically divided into separate taxa. We collected O. viverrini s.l. from eight different locations in Lao PDR and Thailand. The results of nad1, cox1, CF-int6, Pm-int9, ITS2 and 28S rDNA sequence analysis revealed that sub-structuring occurred between the eight populations...
April 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29649604/clonorchis-sinensis-omega-class-glutathione-transferases-are-reliable-biomarkers-for-serodiagnosis-of-clonorchiasis-and-opisthorchiasis
#9
J-G Kim, C-S Ahn, B Sripa, K S Eom, I Kang, W-M Sohn, Y Nawa, Y Kong
OBJECTIVES: To determine the potential for immunodiagnostic application of two recombinant forms of Clonorchis sinensis omega-class glutathione transferases (rCsGSTo1 and rCsGSTo2) against human small liver-fluke C. sinensis and Opisthorchis viverrini infections. METHODS: Specific antibody levels against rCsGSTo1 and rCsGSTo2 in patients' sera of egg-positive opisthorchiasis (n = 87) and clonorchiasis (n = 120), as well as those in sera from patients with other helminthic infections (n = 252) and healthy controls (n = 40) were retrospectively analyzed by enzyme-linked immunosorbent assay (ELISA)...
April 9, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29616885/egg-hatching-mechanism-of-human-liver-fluke-opisthorchis-viverrini-a-role-for-leucine-aminopeptidases-from-the-snail-host-bithynia-siamensis-goniomphalos
#10
Smarn Tesana, P Khampoosa, S Piratae, S Prasopdee, B Sripanidkulchai
The human liver fluke Opisthorchis viverrini (Platyhelminthes, Trematoda, Digenea) uses snails of the genus Bithynia as first intermediate host. Peculiarly among trematodes, the eggs of O. viverrini hatch within the digestive tract of its snail host. It remains uncertain whether hatching in this species is mediated through mechanical fracture of the eggshell or by digestion with specific digestive enzymes. This study aimed to characterize enzymes with specific inhibitor and factors involved in the hatching activity of O...
April 4, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29579789/risk-factors-for-cholangiocarcinoma-in-thailand-a-systematic-review-and-meta-analysis
#11
REVIEW
Siriporn Kamsa-ard, Supot Kamsa-ard, Vor Luvira, Krittika Suwanrungruang, Patravoot Vatanasapt, Surapon Wiangnon
Background and objective: Cholangiocarcinoma remains a serious public health concern in Thailand. While many of the risk factors for cholangiocarcinoma in western countries are well-recognized, it remains unclear whether they are the same in Thailand. We set out to investigate the risk factors for cholangiocarcinoma in Thailand. Methods: Starting March 4, 2016, we reviewed studies found using pre-specified keywords on SCOPUS, Pro Quest Science Direct, PubMed, and online public access catalog of Khon Kaen University...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29529855/comparative-characterization-of-four-calcium-binding-ef-hand-proteins-from-opisthorchis-viverrini
#12
Palida Emmanoch, Nanthawat Kosa, Suksiri Vichasri-Grams, Smarn Tesana, Rudi Grams, Amornrat Geadkaew-Krenc
Four isoforms of calcium binding proteins containing 2 EF hand motifs and a dynein light chain-like domain in the human liver fluke Opisthorchis viverrini , namely OvCaBP1, 2, 3, and 4, were characterized. They had molecular weights of 22.7, 21.6, 23.7, and 22.5 kDa, respectively and showed 37.2-42.1% sequence identity to CaBP22.8 of O. viverrini . All were detected in 2- and 4-week-old immature and mature parasites. Additionally, OvCaBP4 was found in newly excysted juveniles. Polyclonal antibodies against each isoform were generated to detect the native proteins in parasite extracts by Western blot analysis...
February 2018: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29529854/-echinostoma-ilocanum-infection-in-two-residents-of-savannakhet-province-lao-pdr
#13
Jong-Yil Chai, Woon-Mok Sohn, Jaeeun Cho, Keeseon S Eom, Tai-Soon Yong, Duk-Young Min, Eui-Hyug Hoang, Bounlay Phommasack, Bounnaloth Insisiengmay, Han-Jong Rim
Adult specimens of Echinostoma ilocanum (Garrison, 1908) Odhner, 1911 (Trematoda: Echinostomatidae) were recovered from 2 riparian people who resided along the Mekong River in Savannakhet Province, Lao PDR. In fecal examinations done by the Kato-Katz technique, they revealed echinostome eggs together with eggs of Opisthorchis viverrini (and minute intestinal fluke eggs) and hookworms. To recover the adult flukes, they were treated with praziquantel 30-40 mg/kg in a single dose and purged with magnesium salts...
February 2018: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29503819/granulin-secreted-by-the-food-borne-liver-fluke-opisthorchis-viverrini-promotes-angiogenesis-in-human-endothelial-cells
#14
Brandon Haugen, Shannon E Karinshak, Victoria H Mann, Anastas Popratiloff, Alex Loukas, Paul J Brindley, Michael J Smout
The liver fluke Opisthorchis viverrini is a food-borne, zoonotic pathogen endemic to Thailand and adjacent countries in Southeast Asia. The adult developmental stage of the O. viverrini parasite excretes and secretes numerous proteins within the biliary tract including the gall bladder. Lesions caused by the feeding activities of the liver fluke represent wounds that undergo protracted cycles of healing and re-injury during chronic infection, which can last for decades. Components of the excretory/secretory (ES) complement released by the worms capably drive proliferation of bile duct epithelial cells and are implicated in establishing the oncogenic milieu that leads to bile duct cancer, cholangiocarcinoma...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29486176/ultrasonographic-investigation-of-cholangiocarcinoma-in-lao-pdr
#15
Ju Yeong Kim, Tai-Soon Yong, Han-Jong Rim, Jong-Yil Chai, Duk-Young Min, Keeseon S Eom, Woon-Mok Sohn, Jae Hoon Lim, Dongil Choi, Sithat Insisiengmay, Bounlay Phommasack, Bounnaloth Insisiengmay
Opisthorchis viverrini is a group 1 carcinogen that causes cholangiocarcinoma (CCA). Although opisthorchiasis is known to be severely endemic to several areas along the Mekong River in Lao PDR, the CCA status of residents of this region is still under investigation. In this study, we analyzed the results of abdominal ultrasonography (US) performed on 6113 residents in 9 provinces (Vientiane Municipality, Savannakhet, Phongsaly, Khammouane, Saravane, Champasak, Vientiane, Xieng Khuouang, and Luang Prabang provinces) of Lao PDR from 2007 to 2011...
June 2018: Acta Tropica
https://www.readbyqxmd.com/read/29466091/infections-by-hepatic-trematodes-in-cats-from-slaughterhouses-in-vietnam
#16
Hung Manh Nguyen, Yulia V Tatonova, Henry Madsen
Domestic cats are a final host for some hepatic trematodes and cat meat is used for human consumption in several parts of Northern Vietnam. Since there is no tradition for commercial cat rearing in the area, cats are purchased alive from other areas as well, i.e. Southern Vietnam and neighboring countries and brought to slaughter houses. This uncontrolled trade in live cats could pose a risk for spread of various parasites including hepatic trematodes. Hence in this study, we investigated the infections by hepatic trematodes in cats from the slaughter houses...
March 9, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29454982/improved-genomic-resources-and-new-bioinformatic-workflow-for-the-carcinogenic-parasite-clonorchis-sinensis-biotechnological-implications
#17
REVIEW
Daxi Wang, Pasi K Korhonen, Robin B Gasser, Neil D Young
Clonorchis sinensis (family Opisthorchiidae) is an important foodborne parasite that has a major socioeconomic impact on ~35 million people predominantly in China, Vietnam, Korea and the Russian Far East. In humans, infection with C. sinensis causes clonorchiasis, a complex hepatobiliary disease that can induce cholangiocarcinoma (CCA), a malignant cancer of the bile ducts. Central to understanding the epidemiology of this disease is knowledge of genetic variation within and among populations of this parasite...
February 15, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29375936/antifibrotic-effect-of-xanthohumol-in-combination-with-praziquantel-is-associated-with-altered-redox-status-and-reduced-iron-accumulation-during-liver-fluke-associated-cholangiocarcinogenesis
#18
Wassana Jamnongkan, Malinee Thanee, Puangrat Yongvanit, Watcharin Loilome, Raynoo Thanan, Phongsaran Kimawaha, Tidarat Boonmars, Runglawan Silakit, Nisana Namwat, Anchalee Techasen
Cholangiocarcinoma (CCA) caused by infection of the liver fluke Opisthorchis viverrini , (Ov) is the major public health problem in northeast Thailand. Following Ov infection the subsequent molecular changes can be associated by reactive oxygen species (ROS) induced chronic inflammation, advanced periductal fibrosis, and cholangiocarcinogenesis. Notably, resistance to an activation of cell death in prolonged oxidative stress conditions can occur but some damaged/mutated cells could survive and enable clonal expansion...
2018: PeerJ
https://www.readbyqxmd.com/read/29363443/a-cross-sectional-study-on-intestinal-parasitic-infections-in-children-in-suburban-public-primary-schools-saraburi-the-central-region-of-thailand
#19
Buravej Assavapongpaiboon, Uthaitip Bunkasem, Vivornpun Sanprasert, Surang Nuchprayoon
Intestinal parasitic infection rate among school-aged children in Thailand has been decreasing. However, certain intestinal parasites remain problematic in some regions. This cross-sectional study was conducted between February and September 2016 in three suburban government primary schools (KK, BR, and HK), Saraburi, Thailand. Stool was collected from 263 asymptomatic subjects (4-15 years old), using simple direct smear, formalin-ether concentration, Boeck and Drbohlav's Locke-Egg-Serum (LES) medium culture, and agar plate culture...
March 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29346089/genererating-a-core-cluster-of-fasciola-hepatica-virulence-and-immunomodulation-related-genes-using-a-comparative-in-silico-approach
#20
Orçun Haçarız, Gearóid P Sayers
A total of 71 virulence and immunomodulation-related transcripts (VIRs) of Fasciola hepatica have been previously proposed (Haçarız et al., 2015). In an attempt to further refine this cohort, an in silico meta analysis approach was carried out using publicly available sequence data of related liver flukes, Clonorchis sinensis and Opisthorchis viverrini. Data of both liver flukes were investigated in terms of sequential homology with data of non-parasitic organisms, pathogens and VIRs of F. hepatica, directional selection (Ka/Ks), and cytokine signaling relation (protein motif based)...
April 2018: Research in Veterinary Science
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