Cuili Li, Yan Yang, Luan Li, Yingwen Chen, Qingying Shi, Hong Zhang, Li Zhang, Yuanhan Chen, Ruizhao Li, Zhilian Li, Shuangxin Liu, Zhiming Ye, Xingchen Zhao, Xinling Liang
Podocyte injury is linked to the pathogenesis and progression of renal disease. The Transcription Factor EB (TFEB), a master regulator of the autophagy and lysosomal pathways, has been found to exert cell- and tissue-specific biological function. To explore TFEB function and underlying mechanisms in podocytes, a total of 4645 differentially expressed genes (DEGs) were detected in TFEB-knockdown mouse podocytes by transcriptome sequencing. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Ingenuity Pathway Analysis showed that, apart from the enrichment in autophagy and lysosomal pathways, DEGs were enriched in cytoskeleton structure (actin, cytoskeleton, focal adhesion, and adherens junction), as well as cytoskeleton regulatory molecular signaling (Hippo and Rho GTPase Signaling)...
September 13, 2023: Archives of Biochemistry and Biophysics