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https://www.readbyqxmd.com/read/28911850/activation-of-indoleamine-2-3-dioxygenase-pathway-by-olanzapine-augments-antidepressant-effects-of-venlafaxine-in-mice
#1
Jaya Thomas, Razia Khanam, Divya Vohora
Recent clinical studies report antipsychotics as a better option to augment the action of antidepressants in treatment resistant cases. However, the proper mechanisms underlying the antidepressant effect of antipsychotics is still not clear. Indolamine 2, 3 dioxygenase (IDO) pathway is considered to be an important pathway in pro-inflammatory cytokine associated stress-induced depression. The present study investigated the antidepressant effect of venlafaxine, olanzapine and their combinations in chronic forced-swim stress-induced depression in mice...
August 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28905451/gene-edited-human-kidney-organoids-reveal-mechanisms-of-disease-in-podocyte-development
#2
Yong Kyun Kim, Ido Refaeli, Craig R Brooks, Peifeng Jing, Ramila E Gulieva, Michael R Hughes, Nelly M Cruz, Yannan Liu, Angela J Churchill, Yuliang Wang, Hongxia Fu, Jeffrey W Pippin, Lih Y Lin, Stuart J Shankland, A Wayne Vogl, Kelly M McNagny, Benjamin S Freedman
A critical event during kidney organogenesis is the differentiation of podocytes, specialized epithelial cells that filter blood plasma to form urine. Podocytes derived from human pluripotent stem cells (hPSC-podocytes) have recently been generated in nephron-like kidney organoids, but the developmental stage of these cells and their capacity to reveal disease mechanisms remains unclear. Here we show that hPSC-podocytes phenocopy mammalian podocytes at the capillary loop stage (CLS), recapitulating key features of ultrastructure, gene expression, and mutant phenotype...
September 14, 2017: Stem Cells
https://www.readbyqxmd.com/read/28903363/p53-prevent-tumor-invasion-and-metastasis-by-down-regulating-ido-in-lung-cancer
#3
Dongfang Tang, Lu Yue, Ruyong Yao, Lin Zhou, Yuqin Yang, Liming Lu, Wen Gao
In present study, we are to clear demonstrate the genetic evidence of IDO signaling's impact on invasion and metastasis in lung cancer. Here we examined IDO1 expression levels in non-small cell lung cancer (NSCLC) patients (64) tumor/normal pairs underwent RT-PCR and comprehensive histological, immunohistochemica and clinical analysis. The NSCLC cells stably expressing IDO1 was analyzed for migration and invasion assays and the regulatory mechanism in vitro and metastasis assays in vivo. As results, we reported that IDO1 expression increased by more than 3...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901958/pilot-study-of-the-tart-cherry-juice-for-the-treatment-of-insomnia-and-investigation-of-mechanisms
#4
Jack N Losso, John W Finley, Namrata Karki, Ann G Liu, Alfredo Prudente, Russell Tipton, Ying Yu, Frank L Greenway
BACKGROUND: Insomnia is common in the elderly and is associated with chronic disease, but use of hypnotics increases the incidence of falls. Montmorency tart cherry juice has improved insomnia by self-report questionnaire. STUDY QUESTION: Is insomnia confirmed by polysomnography and is tryptophan availability a potential mechanism for treating insomnia? STUDY DESIGN: A placebo-controlled balanced crossover study with subjects older than 50 years and insomnia were randomized to placebo (2 weeks) or cherry juice (2 weeks) (240 mL 2 times/d) separated by a 2-week washout...
March 27, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28901215/presentation-treatment-and-outcomes-in-patients-with-spontaneous-isolated-celiac-and-superior-mesenteric-artery-dissection
#5
Charles DeCarlo, Suvranu Ganguli, Jorge C Borges, Robert M Schainfeld, Ari J Mintz, Jessica Mintz, Michael R Jaff, Ido Weinberg
Spontaneous isolated celiac or superior mesenteric artery (SMA) dissection (SICMAD) is a rare clinical entity. Not much is known about the natural history and appropriate treatment. We retrospectively queried a prospectively collected institutional radiology database for all patients diagnosed with SICMAD from 1990 to 2017. We identified 42 arteries in 40 patients (83.3% male), mean age 54.8 ± 10.9 years, consisting of 24 celiac arteries and 18 SMA. SMA lesions were longer than celiac lesions (5.15 ± 3.81 vs 2...
September 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28901194/acute-renal-graft-versus-host-disease-in-a-murine-model-of-allogeneic-bone-marrow-transplantation
#6
Peter M Schmid, Abdellatif Bouazzaoui, Karin Schmid, Christoph Birner, Christian Schach, Lars S Maier, Ernst Holler, Dierk H Endemann
Acute kidney injury (AKI) is a very common complication after allogeneic bone marrow transplantation (BMT) and is associated with a poor prognosis. Generally, the kidneys are assumed to not be no direct targets of graft-versus-host disease (GvHD), and renal impairment is often attributed to several other factors occurring in the early phase after BMT. Our study aimed to prove the existence of renal GvHD in a fully major histocompatibility complex (MHC)-mismatched model of BALB/c mice conditioned and transplanted according to 2 different intensity protocols...
August 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28895862/immunomodulatory-effects-of-soluble-factors-secreted-by-feline-adipose-tissue-derived-mesenchymal-stem-cells
#7
Hyung-Kyu Chae, Woo-Jin Song, Jin-Ok Ahn, Qiang Li, Bo-Yeon Lee, Kyeong Kweon, Sang-Chul Park, Hwa-Young Youn
Mesenchymal stem cells (MSCs) have immunomodulatory functions and differentiation capacity, and their clinical use is increasing in veterinary species. Although MSCs have been applied in the treatment in various inflammatory diseases, mechanistic research on feline MSCs is lacking. Accordingly, in this study, we aimed to investigate the immunomodulatory mechanisms of MSCs isolated from feline adipose tissue (fATMSCs). fATMSCs from healthy cats were cultured in an appropriate manner and cocultured with transwell-separated allogeneic feline peripheral blood mononuclear cells (fPBMCs) and RAW264...
September 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28894271/laser-induced-linear-field-particle-acceleration-in-free-space
#8
Liang Jie Wong, Kyung-Han Hong, Sergio Carbajo, Arya Fallahi, Philippe Piot, Marin Soljačić, John D Joannopoulos, Franz X Kärtner, Ido Kaminer
Linear-field particle acceleration in free space (which is distinct from geometries like the linac that requires components in the vicinity of the particle) has been studied for over 20 years, and its ability to eventually produce high-quality, high energy multi-particle bunches has remained a subject of great interest. Arguments can certainly be made that linear-field particle acceleration in free space is very doubtful given that first-order electron-photon interactions are forbidden in free space. Nevertheless, we chose to develop an accurate and truly predictive theoretical formalism to explore this remote possibility when intense, few-cycle electromagnetic pulses are used in a computational experiment...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893628/a-combination-of-nanosystems-for-the-delivery-of-cancer-chemoimmunotherapeutic-combinations-1-methyltryptophan-nanocrystals-and-paclitaxel-nanoparticles
#9
P Calleja, J M Irache, C Zandueta, C Martínez-Oharriz, S Espuelas
IDO is an enzyme that tumors use to create a state of immunosupression. 1-D-methyltryptophan (1-MT) is an IDO pathway inhibitor. After being successfully evaluated in preclinical studies, current clinical trials are actually analyzing its efficacy as monotherapy or in combination with multiple chemotherapeutic agents such as paclitaxel. 1-MT very poor solubility in water and many other solvents precludes its ease parenteral administration. It is currently administered by oral route because high daily doses were well-tolerated and effectively inhibited the IDO activity although only 25% of dose was recovered in plasma...
September 8, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28893559/twenty-four-hour-urinary-cortisol-excretion-and-the-metabolic-syndrome-in-prednisolone-treated-renal-transplant-recipients
#10
Laura V de Vries, Wilhelmina H A de Jong, Daan J Touw, Stefan P Berger, Gerjan Navis, Ido P Kema, Stephan J L Bakker
Chronic prednisolone treatment in renal transplant recipients (RTR) causes metabolic abnormalities, which cluster in the metabolic syndrome (MS). It also suppresses the hypothalamic-pituitaryadrenal (HPA)-axis. We investigated whether HPA-axis suppression, as measured by 24h urinary cortisol excretion, is associated with presence of the MS and its individual components, in outpatient RTR with a functioning graft for >1year. Urinary cortisol was measured in 24h urine, using LC-MS/MS (LOQ 0.30nmol/L). We included 563 RTR (age 51±12years; 54% male) at median 6...
September 8, 2017: Steroids
https://www.readbyqxmd.com/read/28890333/static-and-dynamic-dna-loops-form-ap-1-bound-activation-hubs-during-macrophage-development
#11
Douglas H Phanstiel, Kevin Van Bortle, Damek Spacek, Gaelen T Hess, Muhammad Saad Shamim, Ido Machol, Michael I Love, Erez Lieberman Aiden, Michael C Bassik, Michael P Snyder
The three-dimensional arrangement of the human genome comprises a complex network of structural and regulatory chromatin loops important for coordinating changes in transcription during human development. To better understand the mechanisms underlying context-specific 3D chromatin structure and transcription during cellular differentiation, we generated comprehensive in situ Hi-C maps of DNA loops in human monocytes and differentiated macrophages. We demonstrate that dynamic looping events are regulatory rather than structural in nature and uncover widespread coordination of dynamic enhancer activity at preformed and acquired DNA loops...
September 1, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28890300/tau-positron-emission-tomography-using-18-f-thk5351-and-cerebral-glucose-hypometabolism-in-alzheimer-s-disease
#12
Jae Myeong Kang, Sang-Yoon Lee, Seongho Seo, Hye Jin Jeong, Sung-Ho Woo, Hyon Lee, Yeong-Bae Lee, Byeong Kil Yeon, Dong Hoon Shin, Kee Hyung Park, Hyejin Kang, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Victor L Villemagne, Joon-Kyung Seong, Duk L Na, Tatsuo Ido, Jaelim Cho, Kyoung-Min Lee, Young Noh
This study aims to evaluate the clinical validity of [(18)F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition (NC) were included. All subjects underwent [(18)F]THK5351 PET, 3.0-T magnetic resonance imaging, and detailed neuropsychological tests. Regions of interest and voxel-based statistical analyses were performed...
August 12, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28890009/impact-of-onyx%C3%A2-embolization-on-radiosurgical-management-of-cerebral-avm-treatment-and-outcome
#13
Ido Strauss, Oz Haim, Daniel Umansky, Benjamin W Corn, Vladimir Frolov, Natan Shtraus, Shimon Maimon, Andrew A Kanner
BACKGROUND: Stereotactic radiosurgery (SRS) is a well-established treatment modality for cerebral arterio-venous malformations (AVMs). The main limiting factor in the radiosurgical treatment of AVMs is the volume of the nidus with high-grade lesions often requiring combined treatment to reduce the SRS target volume. To overcome this limitation, we have been using a combined treatment approach consisting of endovascular embolization with ONYX followed by SRS. OBJECTIVE: To evaluate our clinical experience for safety and feasibility of this multimodality treatment approach...
September 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28886696/inhibition-of-pi3k-akt-mtor-pathway-sensitizes-endometrial-cancer-cell-lines-to-parp-inhibitors
#14
Charles-André Philip, Ido Laskov, Marie-Claude Beauchamp, Maud Marques, Oreekha Amin, Joanna Bitharas, Roy Kessous, Liron Kogan, Tahira Baloch, Walter H Gotlieb, Amber Yasmeen
BACKGROUND: Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70-80%) and high grade tumors (90%). We assessed the sensitivity of endometrial cancer cell lines to PARP inhibitors (olaparib and BMN-673) and a PI3K inhibitor (BKM-120), alone or in combination, in the context of their PTEN mutation status. We also highlighted a direct pathway linking PTEN to DNA repair. METHODS: Using endometrial cancer cellular models with known PTEN status, we evaluated their homologous recombination (HR) functionality by RAD51 foci formation assay...
September 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28886587/distinct-pattern-of-immune-tolerance-in-dendritic-cells-treated-with-lipopolysaccharide-or-lipoteichoic-acid
#15
Hyo Shin Yoon, Girak Kim, Young Jun Ju, In Su Cheon, Sun Woong Hong, Dong Wook Kim, Byung-Chul Park, Seung Hyun Han, Cheol-Heui Yun
Cytokine induction is often critical for the host defense during acute immune responses while, if not tightly regulated, it may cause an immunological pathology coincident with tissue damage. Despite the fact that gram-positive bacterial infection has become increasingly prevalent, immune modulation induced by lipoteichoic acid (LTA), the major cell wall component of gram-positive bacteria has not been studied thoroughly at the cellular level. In the current study, tolerance induction in mouse bone marrow-derived dendritic cells (BMDCs) treated with single or repeated stimulation of Staphylococcus aureus LTA was compared with those of Escherichia coli lipopolysaccharide (LPS)...
September 5, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28877670/indoleamine-2-3-dioxygenase-ido-increases-during-renal-fibrogenesis-and-its-inhibition-potentiates-tgf-%C3%AE-1-induced-epithelial-to-mesenchymal-transition
#16
Luiz Henrique Gomes Matheus, Gislene Mendes Simão, Taíssa Altieri Amaral, Rodrigo Barbosa Oliveira Brito, Camila Soares Malta, Yves Silva Teles Matos, Alexandre Chagas Santana, Gabriela Gomes Cardoso Rodrigues, Maria Clara Albejante, Erna Elisabeth Bach, Maria Aparecida Dalboni, Cleber Pinto Camacho, Humberto Dellê
BACKGROUND: Indoleamine 2, 3-dioxygenase (IDO) is an immunomodulatory molecule that has been implicated in several biological processes. Although IDO has been linked with some renal diseases, its role in renal fibrosis is still unclear. Because IDO may be modulated by TGF-β1, a potent fibrogenic molecule, we hypothesized that IDO could be involved in renal fibrosis, especially acting in the TGF-β1-induced tubular epithelial-mesenchymal transition (EMT). We analyzed the IDO expression and activity in a model of renal fibrogenesis, and the effect of the IDO inhibitor 1-methyl-tryptophan (MT) on TGF-β1-induced EMT using tubular cell culture...
September 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28872775/the-impact-of-unilateral-oophorectomy-on-ovarian-reserve-in-assisted-reproduction-a-systematic-review-and-meta-analysis
#17
Johnny S Younis, Ibrahim Naoum, Nardin Salem, Yuri Perlitz, Ido Izhaki
BACKGROUND: Women following unilateral oophorectomy (UO) are occasionally encountered during assisted reproduction treatment. OBJECTIVES: To explore the impact of UO on ovarian reserve in assisted reproduction. SEARCH STRATEGY: Electronic database search was performed using PUBMED, EBSCO, ISI, Trip, ClinicalTrial. gov and Cochrane library followed by manual search to identify published research between January 1978 and December 2015. SELECTION CRITERIA: Controlled studies that compared infertile women following UO undergoing IVF-ET treatment with women with two intact ovaries...
September 5, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28871595/role-of-immune-microenvironment-in-gastrointestinal-stromal-tumors
#18
Andrew M Blakely, Andres Matoso, Pallavi A Patil, Ross Taliano, Jason T Machan, Thomas J Miner, Kara A Lombardo, Murray B Resnick, Li-Juan Wang
INTRODUCTION: The immune microenvironment is a prognostic factor for various malignancies. The significance of key players of this immune microenvironment including tumor-infiltrating lymphocytes and expression of programmed death-ligand 1 (PD-L1), indoleamine-2,3-dioxygenase (IDO), and tryptophanyl-tRNA synthetase (WARS) in gastrointestinal stromal tumors (GISTs) is largely unknown. METHODS: Tissue microarrays were constructed from pathology files, 1996-2016. Immunohistochemistry for PD-L1, IDO, WARS was correlated with tumor size, mitoses, and outcomes...
September 4, 2017: Histopathology
https://www.readbyqxmd.com/read/28871365/immune-profiling-of-melanoma-tumors-reflecting-aggressiveness-in-a-preclinical-model
#19
Sotirios P Fortis, Louisa G Mahaira, Eleftheria A Anastasopoulou, Ioannis F Voutsas, Sonia A Perez, Constantin N Baxevanis
Melanoma, like most solid tumors, is highly heterogeneous in terms of invasive, proliferative, and tumor-initiating potential. This heterogeneity is the outcome of differential gene expression resulting from conditions in the tumor microenvironment and the selective pressure of the immune system. To investigate possible signatures combining immune-related gene expression and lymphocyte infiltration, we established a preclinical model using B16.F1-derived clones, in the context of melanoma aggressiveness. Combinatorial analyses revealed that tumors concomitantly expressing low levels of Tnf-a, Pd-1, Il-10, Il-1ra, Ccl5, Ido, high Il-9, and with low infiltration by CD45(+), CD3(+), CD4(+) and CD8(+) cells and a high CD4(+):CD8(+) T cell ratio exhibited the most aggressive growth characteristics...
September 4, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28870127/major-liver-resection-in-pregnancy-three-cases-with-different-etiologies-and-review-of-the-literature
#20
M D Niv Pencovich, Muhammad Younis, Yonatan Lessing, Lilach Zac, Joseph B Lessing, M D Yariv Yogev, Michael J Kupferminc, Ido Nachmany
BACKGROUND: Major liver resection during pregnancy is extremely rare. When required, the associated physiologic and anatomic changes pose specific challenges and greater risk for both mother and fetus Materials and methods: Three cases of major liver resection during pregnancy due to different etiologies are presented. The relevant literature is reviewed and discussed. RESULTS: We present 3 cases of major liver resection due to giant liver hemangioma with Kasabach-Merrit syndrome, giant hydatid cyst, and intrahepatic cholangiocarcinoma, at gestational week (GW) 17, 19, and 30, respectively...
September 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
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