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https://www.readbyqxmd.com/read/29141087/effect-of-granulocyte-macrophage-colony-stimulating-factor-with-or-without-supervised-exercise-on-walking-performance-in-patients-with-peripheral-artery-disease-the-propel-randomized-clinical-trial
#1
Mary M McDermott, Luigi Ferrucci, Lu Tian, Jack M Guralnik, Donald Lloyd-Jones, Melina R Kibbe, Tamar S Polonsky, Kathryn Domanchuk, James H Stein, Lihui Zhao, Doris Taylor, Christopher Skelly, William Pearce, Harris Perlman, Walter McCarthy, Lingyu Li, Ying Gao, Robert Sufit, Christina L Bloomfield, Michael H Criqui
Importance: Benefits of granulocyte-macrophage colony-stimulating factor (GM-CSF) for improving walking ability in people with lower extremity peripheral artery disease (PAD) are unclear. Walking exercise may augment the effects of GM-CSF in PAD, since exercise-induced ischemia enhances progenitor cell release and may promote progenitor cell homing to ischemic calf muscle. Objectives: To determine whether GM-CSF combined with supervised treadmill exercise improves 6-minute walk distance, compared with exercise alone and compared with GM-CSF alone; to determine whether GM-CSF alone improves 6-minute walk more than placebo and whether exercise improves 6-minute walk more than an attention control intervention...
November 15, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29127558/effect-of-dexamethasone-dose-and-route-on-the-duration-of-interscalene-brachial-plexus-block-for-outpatient-arthroscopic-shoulder-surgery-a-randomized-controlled-trial
#2
Darren Holland, Ryan J J Amadeo, Scott Wolfe, Linda Girling, Faylene Funk, Mark Collister, Emily Czaplinski, Celeste Ferguson, Jeff Leiter, Jason Old, Peter MacDonald, Brenden Dufault, Thomas C Mutter
PURPOSE: Dexamethasone prolongs the duration of interscalene block, but the benefits of higher doses and perineural vs intravenous administration remain unclear. METHODS: This factorial design, double-blinded trial randomized 280 adult patients undergoing ambulatory arthroscopic shoulder surgery at a single centre in a 1:1:1:1 ratio. Patients received ultrasound-guided interscalene block with 30 mL 0.5% bupivacaine and 4 mg or 8 mg dexamethasone by either the perineural or intravenous route...
November 10, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29122835/multiple-hotspot-mutations-scanning-by-single-droplet-digital-pcr
#3
Charles Decraene, Amanda Silveira, François-Clément Bidard, Audrey Vallee, Marc Michel, Samia Melaabi, Anne Vincent-Salomon, Adrien Saliou, Alexandre Houy, Maud Milder, Olivier Lantz, Marc Ychou, Marc G Denis, Jean-Yves Pierga, Marc-Henri Stern, Charlotte Proudhon
BACKGROUND: Progress in the liquid biopsy field, combined with the development of droplet digital PCR (ddPCR)(12), has enabled noninvasive monitoring of mutations with high detection accuracy. However, current assays detect a restricted number of mutations per reaction. ddPCR is a recognized method for detecting alterations previously characterized in tumor tissues, but its use as a discovery tool when the mutation is unknown a priori remains limited. METHODS: We established 2 ddPCR assays detecting all genomic alterations within KRAS() exon 2 and EGFR exon 19 mutation hotspots, which are of clinical importance in colorectal and lung cancer, with use of a unique pair of TaqMan® oligoprobes...
November 9, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29114833/effect-of-a-single-dose-of-oral-opioid-and-nonopioid-analgesics-on-acute-extremity-pain-in-the-emergency-department-a-randomized-clinical-trial
#4
Andrew K Chang, Polly E Bijur, David Esses, Douglas P Barnaby, Jesse Baer
Importance: The choice of analgesic to treat acute pain in the emergency department (ED) lacks a clear evidence base. The combination of ibuprofen and acetaminophen (paracetamol) may represent a viable nonopioid alternative. Objectives: To compare the efficacy of 4 oral analgesics. Design, Settings, and Participants: Randomized clinical trial conducted at 2 urban EDs in the Bronx, New York, that included 416 patients aged 21 to 64 years with moderate to severe acute extremity pain enrolled from July 2015 to August 2016...
November 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29108487/a-clinically-meaningful-training-effect-in-walking-speed-using-functional-electrical-stimulation-for-motor-incomplete-spinal-cord-injury
#5
Tamsyn Street, Christine Singleton
CONTEXT/OBJECTIVE: The study aimed to investigate the presence of a training effect for rehabilitation of walking function in motor-incomplete spinal cord injury (SCI) through daily use of functional electrical stimulation (FES). SETTING: A specialist FES outpatient centre Participants: Thirty-five participants (mean age 53, SD 15, range 18-80; mean years since diagnosis 9, range 5 months - 39 years) with drop foot and motor-incomplete SCI (T12 or higher, ASIA Impairment Scale C and D) able to ambulate 10 metres with the use of a walking stick or frame...
November 6, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29103840/the-influence-of-full-thickness-chondral-defects-on-outcomes-following-meniscal-allograft-transplantation-a-comparative-study
#6
Bryan M Saltzman, Maximilian A Meyer, Timothy S Leroux, Matthew E Gilelis, Margot Debot, Adam B Yanke, Brian J Cole
PURPOSE: To compare a series of patients who underwent meniscus allograft transplantation (MAT) with full-thickness chondral defects (FTD) with those with no chondral defect (ND) with regard to the following: change in patient-reported outcomes (PROs) from baseline to 2-year follow-up and baseline to the final follow-up (including comparisons to minimal clinically important differences), complications and complication rates, reoperations and reoperation rates/timing, and failures and time to failure (revision MAT or conversion to total knee arthroplasty)...
November 2, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29102112/refinement-of-the-equine-influenza-model-in-the-natural-host-a-meta-analysis-to-determine-the-benefits-of-individual-nebulisation-for-experimental-infection-and-vaccine-evaluation-in-the-face-of-decreased-strain-pathogenicity
#7
Dion Garrett, Fernando Montesso, Stéphanie Fougerolle, Maria R Lopez-Alvarez, Ilhan Birand, Manuelle De Bock, Chengjin M Huang, Loïc Legrand, Stéphane Pronost, Romain Paillot
Equine Influenza (EI) is an important respiratory disease of horses caused by H3N8 equine influenza viruses (EIV). Vaccination is a key strategy to prevent or control this disease. However, EIV undergoes continuous antigenic drift and whilst numerous EI vaccines are commercially available worldwide, an accurate evaluation of their efficacy is frequently required through clinical trials conducted in the natural host. Room nebulisation is one of the chosen methods to challenge horses during EI vaccine studies...
November 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29099823/-standardization-of-data-collection-in-midwifery-care-a-literature-review
#8
Barbara Burlon, Fabio D'Agostino, Sofia Colaceci, Antonello Cocchieri, Ercole Vellone, Maurizio Zega, Rosaria Alvaro
INTRODUCTION: midwifery records currently do not systematically collect data regarding midwifery care provided. Midwifery Minimum Data Sets (MMDS) have been developed to perform uniform and standardized data collection. AIM: to describe features, purposes and use of MMDSs in obstetrical care. METHOD: a literature review was conducted using Medline, CINAHL and Scopus databases. The following key words were used: "data set", "midwifery" and "maternity care...
July 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29095407/serious-adverse-events-significantly-reduce-patient-reported-outcomes-at-2-year-follow-up-nonoperative-multicenter-prospective-nih-study-of-105-patients
#9
Andrew J Pugely, Michael P Kelly, Christine R Baldus, Yubo Gao, Lukas Zebala, Christopher Shaffrey, Steven Glassman, Oheneba Boachie-Adjei, Stefan Parent, Stephen Lewis, Tyler Koski, Charles Edwards, Frank Schwab, Keith H Bridwell
STUDY DESIGN: This is an analysis of a prospective 2-year study on nonoperative patients enrolled in the Adult Symptomatic Lumbar Scoliosis (ASLS) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) trial. OBJECTIVE: The purpose was to evaluate the impact of serious adverse events (SAEs) on patient-reported outcomes (PROs) in nonoperative management of ASLS as measured by Scoliosis Research Society-22r (SRS-22r), Oswestry Disability Index (ODI) and Short Form-12 (SF-12) at 2-year follow-up...
October 31, 2017: Spine
https://www.readbyqxmd.com/read/29093966/rethink-space-re-designing-a-workspace-using-human-centered-design-to-support-flexibility-collaboration-and-engagement-among-clinical-and-translational-research-support-services
#10
Aalap Doshi, Christina Clay
Introduction: Space matters. We read space like we read people's faces. Space is an instrument of collaboration and innovation. At the University of Michigan's Institute for Clinical and Health Research (MICHR), a team was created to creatively and economically enhance our operating space into a flexible workspace that supports privacy, innovation, creativity, and most important, a culture of collaboration. Methods: The team used a human-centered design process to creatively engage the staff at large into analyzing our existing space, identifying latent needs, proposing solutions, generating feedback, and economically building the rethought process...
June 2017: Journal of clinical and translational science
https://www.readbyqxmd.com/read/29091739/postnatal-nutritional-treatment-of-neurocognitive-deficits-in-foetal-alcohol-spectrum-disorder-fasd
#11
Adriana Bastons-Compta, Marta Astals, Vicente Andreu, Elisabet Navarro, Oscar Garcia-Algar
Ethanol is the most important teratogen agent in humans. Prenatal alcohol exposure can lead to a wide range of adverse effects, which are broadly termed as Foetal Alcohol Spectrum Disorder (FASD). Socioeconomic status, ethnicity, differences in genetic susceptibility related to ethanol metabolism, alcohol consumption patterns, obstetric problems, maternal nutrition, stress, and other co-administered drugs are all factors that may influence FASD manifestations. Recently, much attention has been paid to the role of nutrition as a protective factor against alcohol teratogenicity...
November 1, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29090734/physical-exercise-training-for-cystic-fibrosis
#12
REVIEW
Thomas Radtke, Sarah J Nevitt, Helge Hebestreit, Susi Kriemler
BACKGROUND: Physical exercise training may form an important part of regular care for people with cystic fibrosis. This is an update of a previously published review. OBJECTIVES: To assess the effects of physical exercise training on exercise capacity by peak oxygen consumption, pulmonary function by forced expiratory volume in one second, health-related quality of life and further important patient-relevant outcomes in people with cystic fibrosis. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings...
November 1, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29090263/respiratory-events-with-sugammadex-vs-neostigmine-following-laparoscopic-sleeve-gastrectomy-a-prospective-pilot-study-assessing-neuromuscular-reversal-strategies
#13
Shmuel Evron, Yuri Abelansky, Tiberiu Ezri, Alexander Izakson
Abdominal surgery in obese patients may be associated with pulmonary morbidity, and mortality. Some patients may arrive in the PACU with residual paralysis. The purpose of this study was to find out if there was an association between the type of muscle relaxant reversal agent and the development of postoperative respiratory events in patients undergoing laparoscopic sleeve gastrectomy surgery. METHODS: From September 2012 to February 2013, in a prospective randomized pilot study, two different muscle relaxant reversal agents were administered at the end of surgery in 57 patients undergoing laparoscopic sleeve gastrectomy: sugammadex 2 mg/kg (32 patients) vs...
October 2017: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/29080002/how-does-patient-rated-outcome-change-over-time-following-the-surgical-treatment-of-degenerative-disorders-of-the-thoracolumbar-spine
#14
Tamas F Fekete, M Loibl, D Jeszenszky, D Haschtmann, P Banczerowski, F S Kleinstück, H J Becker, F Porchet, A F Mannion
PURPOSE: Patient-rated measures are considered the gold standard for assessing the outcome of spine surgery, but there is no consensus on the appropriate timing of follow-up. Journals often demand a minimum 2-year follow-up, but the indiscriminate application of this principle may not be warranted. We examined the course of change in patient outcomes up to 5 years after surgery for degenerative spinal disorders. METHODS: The data were evaluated from 4287 consecutive patients (2287 women, 2000 men; aged 62 ± 15 years) with degenerative disorders of the thoracolumbar spine, undergoing first-time surgery at the given level between 01/01/2005 and 31/12/2011...
October 27, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29079501/beyond-discrimination-a-comparison-of-calibration-methods-and-clinical-usefulness-of-predictive-models-of-readmission-risk
#15
Colin G Walsh, Kavya Sharman, George Hripcsak
BACKGROUND: Prior to implementing predictive models in novel settings, analyses of calibration and clinical usefulness remain as important as discrimination, but they are not frequently discussed. Calibration is a model's reflection of actual outcome prevalence in its predictions. Clinical usefulness refers to the utilities, costs, and harms of using a predictive model in practice. A decision analytic approach to calibrating and selecting an optimal intervention threshold may help maximize the impact of readmission risk and other preventive interventions...
October 24, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29079262/functional-and-radiographic-outcomes-after-arthroscopic-transosseous-suture-repair-of-medium-sized-rotator-cuff-tears
#16
Xiao Ning Liu, Cheol-Jung Yang, Geun Woo Lee, Sang Hyun Kim, Yong-Hyun Yoon, Kyu-Cheol Noh
PURPOSE: To evaluate the functional and anatomical outcomes after arthroscopic transosseous suture (TOS) repair of 2 to 4 cm sized rotator cuff tears and to identify preoperative factors influencing repair failure. METHODS: From May 2013 to August 2014, patients with symptomatic 2 to 4 cm full-thickness tears underwent arthroscopic TOS repair, and those who could be followed up for a minimum of 2 years were included in this retrospective study. Functional and anatomical outcomes were analyzed up to 2 years postoperatively...
October 24, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29074939/oral-medicine-in-europe-past-present-and-future
#17
C Bez, A Sklavounou, M Carrozzo
Oral medicine (OM) is a relatively young dental specialty usually dealing with the oral healthcare of patients suffering from chronic recurrent and medically-related disorders of the mouth and maxillofacial region and with their diagnosis and mostly non-surgical management. The beginning of OM goes back to 1925 in the USA and 1950s in Europe. However, official specialty recognition is more recent and within Europe, it is only in the UK, Croatia and Israel where OM is recognised by local registering authorities, although in several other European countries it is viewed as a distinct field of study...
December 2017: British Dental Journal
https://www.readbyqxmd.com/read/29065895/associations-between-community-based-physiotherapy-for-musculoskeletal-injury-and-health-related-quality-of-life-eq-5d-a-multi-centre-retrospective-analysis
#18
Nick Caplan, H Robson, A Robson, G Barry, G Wilkes
BACKGROUND: Community-based musculoskeletal physiotherapy is used to improve function and health related quality of life (HRQoL). The purpose of this retrospective, multi-centre observational study was to determine the association between community-based physiotherapy management for musculoskeletal disorders and changes in HRQoL. METHODS: Four thousand one hundred twelve patients' data were included in the study. Patients were included if they received a single period of treatment for a musculoskeletal injury or disorder...
October 25, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29057338/single-anterior-cervical-discectomy-and-fusion-acdf-using-self-locking-stand-alone-polyetheretherketone-peek-cage-evaluation-of-pain-and-health-related-quality-of-life
#19
Stylianos Kapetanakis, Tryfon Thomaidis, George Charitoudis, Pavlos Pavlidis, Panagiotis Theodosiadis, Grigorios Gkasdaris
BACKGROUND: Anterior cervical discectomy and fusion (ACDF) constitutes the conventional treatment of cervical disc herniation due to degenerative disc disease (DDD). ACDF with plating presents a variety of complications postoperatively and stand-alone cages are thought to be a promising alternative. The aim of this study was firstly, to analyze prospectively collected data from a sample of patients treated with single ACDF using C-Plus self-locking stand-alone PEEK cage system, without the use of plates or screws, in order to evaluate pain levels of patients, utilizing Neck and Arm Pain scale as an expression of visual analogue scale (VAS)...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29053911/investigating-the-minimal-clinically-important-difference-for-snot-22-symptom-domains-in-surgically-managed-chronic-rhinosinusitis
#20
Naweed I Chowdhury, Jess C Mace, Todd E Bodner, Jeremiah A Alt, Adam S Deconde, Joshua M Levy, Timothy L Smith
BACKGROUND: Prior work has described 5 domains within the 22-item Sino-Nasal Outcomes Test (SNOT-22) that allow for stratification of symptoms into similar clusters and that can be used to direct therapy. Although the outcomes of various interventions on these symptom domains have been reported, minimal clinically important difference (MCID) values have not been investigated, which has limited clinical interpretation of these results. METHODS: This study was designed as a secondary analysis of a prospective, multi-institutional, observational cohort...
October 20, 2017: International Forum of Allergy & Rhinology
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