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Minimum clinically important difference

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https://www.readbyqxmd.com/read/28929963/-comparison-of-phenotypic-methods-and-polymerase-chain-reaction-for-the-detection-of-carbapenemase-production-in-clinical-klebsiella-pneumoniae-isolates
#1
Yamaç Tekintaş, Feriha Çilli, Bayrı Eraç, Melike Yaşar, Sabire Şöhret Aydemir, Mine Hoşgör Limoncu
Being a member of the Enterobacteriaceae family, Klebsiella pneumoniae is an opportunistic pathogen that inhabits normal human microbiota and causes predominantly hospital-acquired infections. The emergence of K.pneumoniae isolates which are resistant particularly to the carbapenem group of antibiotics has led to an increase in hospitalization period, mortality and morbidity. Although different rates of resistance are observed between countries, regions and even healthcare facilities, there has been a rapid increase in the prevalence of carbapenem-resistant strains in the last 10 years...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28887286/why-does-the-health-related-quality-of-life-in-idiopathic-normal-pressure-hydrocephalus-fail-to-improve-despite-the-favorable-clinical-outcome
#2
Junkkari Antti, Roine Risto P, Luikku Antti, Rauramaa Tuomas, Sintonen Harri, Nerg Ossi, Koivisto Anne M, Häyrinen Antti, Viinamäki Heimo, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville
OBJECTIVE: Occasionally a favorable clinical disease-specific outcome does not reflect into improved generic health-related quality of life (HRQoL) in patients with idiopathic normal pressure hydrocephalus (iNPH) one year after the installation of the cerebrospinal fluid (CSF) shunt. Our aim was to identify factors causing this discrepancy. METHODS: The one-year HRQoL outcome of 141 iNPH patients was evaluated using the generic 15D instrument, in which the minimum clinically important change/difference on the 0-1 scale has been estimated to be ± 0...
September 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28887072/minimum-clinically-important-difference-of-montreal-cognitive-assessment-in-aneurysmal-subarachnoid-hemorrhage-patients
#3
George Kwok Chu Wong, Jodhy Suk Ying Mak, Adrian Wong, Vera Zhi Yuan Zheng, Wai Sang Poon, Jill Abrigo, Vincent Chung Tong Mok
Cognitive impairment is a major factor contributing to poor functional outcome after subarachnoid hemorrhage caused by a ruptured cerebral aneurysm (aSAH). Montreal Cognitive Assessment (MoCA) has been shown to be superior to the Mini-Mental State Examination in screening for cognitive domain deficit and correlating to functional outcome in aSAH patients. The aim of the current study was to determine the Montreal Cognitive Assessment (MoCA) score change that was associated with change of health in general in an aSAH patient cohort...
September 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28886205/placebo-response-and-remission-rates-in-randomised-trials-of-induction-and-maintenance-therapy-for-ulcerative-colitis
#4
REVIEW
Vipul Jairath, G Y Zou, Claire E Parker, John K MacDonald, Turki AlAmeel, Mohammad Al Beshir, Majid A Almadi, Talal Al-Taweel, Nathan Ss Atkinson, Sujata Biswas, Thomas Chapman, Parambir S Dulai, Mark A Glaire, Daniël R Hoekman, Andreas Koutsoumpas, Elizabeth Minas, Mahmoud H Mosli, Mark Samaan, Reena Khanna, Simon Travis, Geert D'Haens, William J Sandborn, Brian G Feagan
BACKGROUND: It is important to minimize placebo rates in randomised controlled trials (RCTs) to efficiently detect treatment differences between interventions. Historically, high placebo rates have been observed in clinical trials of ulcerative colitis (UC). A better understanding of factors influencing placebo rates may lead to more informed clinical trial design. OBJECTIVES: A systematic review and meta-analysis was conducted to evaluate placebo response and remission rates in RCTs evaluating UC treatments in adult patients...
September 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28883090/validity-responsiveness-and-minimum-clinically-important-difference-of-the-incremental-shuttle-walk-in-idiopathic-pulmonary-fibrosis-a-prospective-study
#5
Claire M Nolan, Veronica Delogu, Matthew Maddocks, Suhani Patel, Ruth E Barker, Sarah E Jones, Samantha S C Kon, Toby M Maher, Paul Cullinan, William D-C Man
The incremental shuttle walk (ISW) is well validated in COPD but limited psychometric data restrict its use in idiopathic pulmonary fibrosis (IPF). Study 1: 50 patients performed the ISW and 6 min walk test (6MWT). Study 2: 72 patients completed the ISW before and after pulmonary rehabilitation (PR). The ISW correlated strongly with 6MWT distance (r=0.81,p<0.0001). Mean (95% confidence interval) improvement in ISW with PR was 54 (38 to 70) m with an effect size of 0.29. Distribution-based and anchor-based minimum clinically important difference (MCID) estimates ranged from 31 to 46 m...
September 7, 2017: Thorax
https://www.readbyqxmd.com/read/28882527/successful-lumbar-surgery-results-in-improved-psychological-well-being-a-longitudinal-assessment-of-depressive-and-anxiety-symptoms
#6
Carol A Mancuso, Roland Duculan, Frank P Cammisa, Andrew A Sama, Alexander P Hughes, Darren R Lebl, Federico P Girardi
BACKGROUND CONTEXT: Preoperative psychological symptoms predict surgical outcomes. The impact of surgical outcomes on psychological well-being, however, has not been delineated. PURPOSE: To compare pre- to postoperative depressive and anxiety symptoms based on success of surgery, defined as fulfilled expectations and improvement in disability and pain. STUDY DESIGN/SETTING: Prospective two-year longitudinal study in a tertiary care center PATIENT SAMPLE: 276 lumbar surgery patients OUTCOME MEASURES: the Geriatric Depression Scale (GDS) and the Spielberger State Anxiety Inventory (STAI) METHODS: Patients completed the following validated surveys several days before and again two years after surgery: the GDS with a set threshold for a positive screen for depression; the STAI with population norms used as threshold values; the Oswestry Disability Index (ODI); a numerical pain rating; and the Expectations Survey measuring amount of improvement expected...
September 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28881121/the-predictable-factors-of-the-postoperative-kyphotic-change-of-sagittal-alignment-of-the-cervical-spine-after-the-laminoplasty
#7
Jun Seok Lee, Dong Wuk Son, Su Hun Lee, Dong Ha Kim, Sang Weon Lee, Geun Sung Song
OBJECTIVE: Laminoplasty is an effective surgical method for treating cervical degenerative disease. However, postoperative complications such as kyphosis, restriction of neck motion, and instability are often reported. Despite sufficient preoperative lordosis, this procedure often aggravates the lordotic curve of the cervical spine and straightens cervical alignment. Hence, it is important to examine preoperative risk factors associated with postoperative kyphotic alignment changes. Our study aimed to investigate preoperative radiologic parameters associated with kyphotic deformity post laminoplasty...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28872525/thumb-ossification-composite-index-toci-for-predicting-peripubertal-skeletal-maturity-and-peak-height-velocity-in-idiopathic-scoliosis-a-validation-study-of-premenarchal-girls-with-adolescent-idiopathic-scoliosis-followed-longitudinally-until-skeletal-maturity
#8
Alec L H Hung, W W Chau, B Shi, Simon K Chow, Fiona Y P Yu, T P Lam, Bobby K W Ng, Y Qiu, Jack C Y Cheng
BACKGROUND: Accurate skeletal maturity assessment is important to guide clinical evaluation of idiopathic scoliosis, but commonly used methods are inadequate or too complex for rapid clinical use. The objective of the study was to propose a new simplified staging method, called the thumb ossification composite index (TOCI), based on the ossification pattern of the 2 thumb epiphyses and the adductor sesamoid bone; to determine its accuracy in predicting skeletal maturation when compared with the Sanders simplified skeletal maturity system (SSMS); and to validate its interrater and intrarater reliability...
September 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28867569/quality-of-life-one-year-after-epilepsy-surgery
#9
Victoria Ives-Deliperi, James Thomas Butler
BACKGROUND: The aim of surgery for medically intractable epilepsy was to achieve seizure freedom and improve overall quality of life (QOL) in patients. This investigation looked at changes in QOL one year after epilepsy surgery and the relationship of changes to mood, language, and seizure outcomes. METHOD: Depressive symptoms, QOL, and naming were measured in 25 patients with temporal lobe epilepsy before and one year after dominant temporal lobe resection. The Quality of Life in Epilepsy-89 (QOLIE-89), Beck Depression Inventory II (BDI-II), and Boston Naming Test (BNT) were used, respectively, and seizure outcome was reported according to the Engel classifications...
August 31, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28852345/outside-in-vs-anteromedial-portal-drilling-during-primary-acl-reconstruction-comparison-at-two-years
#10
Tyler CarlLee, Zach Ries, Kyle Duchman, Yubo Gao, Brian Wolf, Annunziato Amendola, Carolyn Hettrich, Matthew Bollier
BACKGROUND: Anteromedial (AM) and outside-in (OI) are two commonly used techniques for drilling the femoral tunnel during anterior cruciate ligament reconstruction (ACLR). The purpose of this study was to compare clinical and radiographic outcomes of patients undergoing primary ACLR using either AM or OI femoral drilling with minimum two year follow-up. METHODS: Overall, 138 prospectively enrolled patients undergoing primary ACLR underwent AM or OI femoral drilling...
2017: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/28843217/systematic-review-of-hospital-based-cancer-registries-hbcrs-necessary-tool-to-improve-quality-of-care-in-cancer-patients
#11
Zeinab Mohammadzadeh, Marjan Ghazisaeedi, Azin Nahvijou, Sharareh Rostam Niakan Kalhori, Somayeh Davoodi, Kazem Zendehdel
Introduction: Incidence and mortality rate of cancer is increasing in all countries including low and middle-income countries. Hospital based cancer registry (HBCR) is an important tool for administration purpose and improvement of the quality of care. It is also important resource for population based cancer registries. In this study we reviewed HBCRs in different countries. Methods: We searched the published literature using the MEDLINE (PubMed), Google scholar, Scopus, ProQuest and Google. We also reviewed websites of the HBCRs in different countries...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28840150/outcomes-for-arthroscopic-treatment-of-anterior-inferior-iliac-spine-subspine-hip-impingement
#12
Benedict U Nwachukwu, Brenda Chang, Kara Fields, Jeremy Rinzler, Danyal H Nawabi, Anil S Ranawat, Bryan T Kelly
BACKGROUND: Femoroacetabular hip impingement (FAI) is now well recognized; however, anterior inferior iliac spine (AIIS; or subspine) impingement is a form of hip impingement that is underrecognized and can be an important source of hip disability and functional limitation. PURPOSE: To investigate the outcomes after arthroscopic treatment of AIIS/subspine-related hip impingement in the absence of FAI surgery. STUDY DESIGN: Case series; Level of evidence, 4...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28838263/evaluation-of-oxidative-stress-via-protein-expression-of-glutathion-s-transferase-and-cytochrome-p450-cyp450-isoenzymes-in-psoriasis-vulgaris-patients-treated-with-methotrexate
#13
Ozge Akbulak, Ayse Serap Karadag, Necmettin Akdeniz, Seyma Ozkanli, Emin Ozlu, Ebru Zemheri, Serpil Oguztuzun
INTRODUCTION: Oxidative stress is the imbalance between oxidant-antioxidant systems and may play a major role in the psoriasis pathogenesis. Cytochrome (CYP) is a family of enzymes which are responsible for the metabolism of various endogenous and exogenous substances such as drug metabolism. Most importantly, the antioxidant system is the Glutathione- S transferases (GST) which decrease oxidative stress by reducing oxidative products. AIM: We aimed to evaluate the expressions of isoenzymes of GST and CYP families and the beneficial role of metotrexate (MTX) in this process...
August 24, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28836662/health-related-quality-of-life-and-emotional-well-being-after-epilepsy-surgery-a-prospective-controlled-long-term-follow-up
#14
Anna Edelvik, Charles Taft, Gerd Ekstedt, Kristina Malmgren
OBJECTIVE: To evaluate health-related quality of life (HRQOL) and emotional well-being in resective epilepsy surgery and nonoperated patients at long-term follow-up. METHODS: This is a prospective cohort study where patients undergoing presurgical work-up during 1995-1998 completed the Short-Form Health Survey (SF-36) and the Hospital Anxiety and Depression scale (HAD) at baseline, and 2 and 14 years after resective surgery or presurgical evaluation (nonoperated patients)...
August 24, 2017: Epilepsia
https://www.readbyqxmd.com/read/28833656/the-in-vitro-antibacterial-activity-of-incomplete-iron-salt-of-polyacrylic-acid-against-pseudomonas-aeruginosa-meticillin-resistant-staphylococcus-pseudintermedius-and-meticillin-resistant-s-aureus
#15
Meghan K Solc, J Scott Weese, Edward Jazic
BACKGROUND: The incomplete iron salt of polyacrylic acid (IIS-PAA) has been used for its haemostatic, wound healing and antibacterial properties in human patients. IIS-PAA is a water-soluble, acidic, hydrophilic polymer that is active at pH 2.9-4.0. HYPOTHESES/OBJECTIVES: To evaluate the antibacterial effect of IIS-PAA against Pseudomonas aeruginosa, meticillin-resistant Staphylococcus pseudintermedius (MRSP) and meticillin-resistant S. aureus (MRSA). METHODS: This was a prospective, nonblinded in vitro study...
August 22, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28829650/user-acceptance-factors-of-hospital-information-systems-and-related-technologies-systematic-review
#16
Putu Wuri Handayani, Achmad Nizar Hidayanto, Indra Budi
This study reviews the literature on the most important acceptance factors associated with Hospital Information Systems (HIS) and related technologies based on user groups' perspectives (medical staff, hospital management, administrative personnel, patient, medical student, and IT staff), which can assist researchers and hospital management to develop suitable acceptance models to improve the quality of HIS. We conducted searches in online databases with large repositories of academic studies, written in English and fully accessible by the authors...
August 22, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/28825846/sleep-disturbance-in-smokers-with-preserved-pulmonary-function-and-chronic-obstructive-pulmonary-disease
#17
Lucas M Donovan, Peter J Rise, Shannon S Carson, Laura C Feemster, Matthew F Griffith, Vishesh K Kapur, Jerry A Krishnan, Peter K Lindenauer, Richard A Mularski, Edward T Naureckas, Brian N Palen, Elizabeth C Parsons, Laura J Spece, Michael V Vitiello, David H Au
RATIONALE: Sleep disturbance frequently affects patients with chronic obstructive pulmonary disease (COPD), and is associated with reduced quality of life and poorer outcomes. Recent data indicate that smokers with preserved pulmonary function have clinical symptoms similar to those meeting spirometric criteria for COPD, but little is known about the driving factors for sleep disturbance in this population of emerging interest. OBJECTIVES: To compare the magnitude and correlates of sleep disturbance between smokers with preserved pulmonary function and those with airflow obstruction...
August 21, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28821444/circumferential-fusion-a-comparative-analysis-between-anterior-lumbar-interbody-fusion-with-posterior-pedicle-screw-fixation-and-transforaminal-lumbar-interbody-fusion-for-l5-s1-isthmic-spondylolisthesis
#18
Erik Y Tye, Joseph E Tanenbaum, Andrea S Alonso, Roy Xiao, Michael P Steinmetz, Thomas E Mroz, Jason W Savage
BACKGROUND CONTEXT: Transforaminal lumbar interbody fusion (TLIF) or anterior lumbar interbody fusion with percutaneous pedicle screws (ALIFPS) offer significantly higher radiographic fusion rates than other fusion techniques for L5-S1 isthmic spondylolisthesis (IS). As it stands, there is a relative paucity of comparative data of the two techniques. PURPOSE: To define the clinical, radiographic, and financial differences between TLIF and ALIFPS for L5-S1 IS. STUDY DESIGN/SETTING: A retrospective cohort study conducted at a single-tertiary care center...
August 15, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28820272/a-comparison-of-clinical-outcomes-after-unilateral-or-bilateral-hip-arthroscopic-surgery-age-and-sex-matched-cohort-study
#19
Benjamin D Kuhns, Charles P Hannon, Eric C Makhni, Jennifer Alter, Richard C Mather, Michael J Salata, Shane J Nho
BACKGROUND: A significant number of patients undergoing hip arthroscopic surgery for femoroacetabular impingement (FAI) have bilateral deformities and may require surgery for both hips. PURPOSE: To compare outcomes between patients who underwent bilateral hip arthroscopic surgery to a matched cohort of patients who underwent unilateral hip arthroscopic surgery. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: A consecutive series of patients who underwent primary hip arthroscopic surgery for FAI by a single fellowship-trained surgeon from January 2012 to January 2014 and had a minimum follow-up of 2 years were evaluated...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28803652/long-term-follow-up-evaluation-of-autologous-chondrocyte-implantation-for-symptomatic-cartilage-lesions-of-the-knee-a-single-centre-prospective-study
#20
M Berruto, P Ferrua, S Pasqualotto, F Uboldi, A Maione, D Tradati, E Usellini
INTRODUCTION: Autologous Chondrocyte Implantation (ACI) has been the first technique in reconstruction of a valid articular surface. The aim of this study was to evaluate clinical results of this technique at an average follow up of 162±27months (range 88-208) in a group of patients who underwent ACI. MATERIALS AND METHODS: 32 patients were operated between 1997 and 2007 for chondral lesions or osteochondritis dissecans of the knee. Mean size of the defect was 5...
August 4, 2017: Injury
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