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https://www.readbyqxmd.com/read/28444965/serum-free-light-chain-quantitative-assays-dilemma-of-a-biomarker
#1
Giovanni Cigliana, Francesca Gulli, Cecilia Napodano, Krizia Pocino, Elena De Santis, Luigi Colacicco, Iole Cordone, Laura Conti, Umberto Basile
BACKGROUND: Serum free light chains detection assays are consistently meeting greater interest for the diagnosis and monitoring of monoclonal gammopathies and plasma cell dyscrasias. Nowadays, there are neither standardized methods nor reference material for the determination of free light chains; for this reason, it is important to compare two different assays used in clinical laboratory. METHODS: We evaluated 300 serum samples from patients with B-cell disorders and compared the analytical performances of both assay...
April 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28443167/elderly-patients-achieving-clinical-and-radiological-outcomes-comparable-with-those-of-younger-patients-following-minimally-invasive-transforaminal-lumbar-interbody-fusion
#2
Joshi Nikhil N, Joel Wei-An Lim, William Yeo, Wai-Mun Yue
STUDY DESIGN: Retrospective analysis of prospective database. PURPOSE: To compare 2-year clinical and radiological outcomes after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) among "middle-age" (50-64.99 years), "young-old" (65-74.99 years), and "old-old" (>75 years) patients. OVERVIEW OF LITERATURE: Owing to higher perioperative morbidity and mortality rates, elderly patients with degenerative lumbar conditions are occasionally denied surgical care, even after conservative treatment failure...
April 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28439881/effect-of-cocoa-on-blood-pressure
#3
REVIEW
Karin Ried, Peter Fakler, Nigel P Stocks
BACKGROUND: High blood pressure is an important risk factor for cardiovascular disease, contributing to about 50% of cardiovascular events worldwide and 37% of cardiovascular-related deaths in Western populations. Epidemiological studies suggest that cocoa-rich products reduce the risk of cardiovascular disease. Flavanols found in cocoa have been shown to increase the formation of endothelial nitric oxide which promotes vasodilation and therefore blood pressure reduction. Here we update previous meta-analyses on the effect of cocoa on blood pressure...
April 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28434911/does-quantity-ensure-quality-standardized-osce-stations-for-outcome-oriented-evaluation-of-practical-skills-at-different-medical-faculties
#4
Iris Schleicher, Karsten Leitner, Jana Juenger, Andreas Moeltner, Miriam Ruesseler, Bernd Bender, Jasmina Sterz, Tina Stibane, Sarah Koenig, Susanne Frankenhauser, Joachim Gerhard Kreuder
BACKGROUND: Practical skills are often assessed using Objective Structured Clinical Skill Exams (OSCE). Nevertheless, in Germany, interchange and agreement between different medical faculties or a general agreement on the minimum standard for passing is lacking. METHODS: We developed standardized OSCE-stations for assessing structured clinical examination of knee and shoulder joint with identical checklists and evaluation standards. These were implemented into the OSCE-course at five different medical faculties...
April 20, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28434694/a-prospective-randomized-trial-of-mini-incision-posterior-and-2-incision-total-hip-arthroplasty-minimum-5-year-follow-up
#5
Robert A Sershon, Matthew W Tetreault, Craig J Della Valle
BACKGROUND: We previously described the results of a randomized controlled trial of mini-posterior vs 2-incision total hip arthroplasty and were unable to demonstrate significant differences in early outcomes. As less-invasive anterior approaches remain popular, the purpose of this report was to re-examine the outcomes at a minimum 5-year follow-up. METHODS: Seventy-two patients undergoing primary total hip arthroplasty were randomized to a mini-posterior or 2-incision approach...
March 23, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28432737/outcome-reporting-across-randomised-controlled-trials-evaluating-therapeutic-interventions-for-pre-eclampsia-a-systematic-review
#6
REVIEW
James M N Duffy, Martin Hirsch, Anusuya Kawsar, Chris Gale, Louise Pealing, Maria N Plana, Marian Showell, Paula R Williamson, Khalid S Khan, Sue Ziebland, Richard J McManus
BACKGROUND: Standardising outcome collection and reporting in pre-eclampsia trials requires an appraisal of current outcome reporting. OBJECTIVES: To map maternal and offspring outcome reporting across randomised trials evaluating therapeutic interventions for pre-eclampsia. SEARCH STRATEGY: Randomised trials were identified by searching bibliographical databases from inception to January 2016. SELECTION CRITERIA: Randomised controlled trials...
April 22, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28431578/is-the-effectiveness-of-patellofemoral-bracing-modified-by-patellofemoral-alignment-and-trochlear-morphology
#7
Xi Zhang, Jillian P Eyles, Joanna Makovey, Matthew J Williams, David J Hunter
BACKGROUND: This study was performed to determine if the effectiveness of patellofemoral bracing as a treatment for patellofemoral osteoarthritis is influenced by patellofemoral joint alignment and trochlear morphology. We hypothesized that those with more extreme patellar malalignment would benefit more from bracing. METHODS: Thirty-eight patients who had received bracing as part of a comprehensive treatment plan for patellofemoral osteoarthritis were selected for this study...
April 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28419159/oral-potassium-supplementation-for-management-of-essential-hypertension-a-meta-analysis-of-randomized-controlled-trials
#8
Jalal Poorolajal, Fatemeh Zeraati, Ali Reza Soltanian, Vida Sheikh, Elham Hooshmand, Akram Maleki
IMPORTANCE: Increased dietary potassium intake is thought to be associated with low blood pressure (BP). Whether potassium supplementation may be used as an antihypertensive agent is a question that should be answered. OBJECTIVE: To assess the effect of oral potassium supplementation on blood pressure in patients with primary hypertension. SEARCH METHODS: We searched Medline, Web of Science, Scopus, Cochrane Central Register of Controlled Trials until October 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28419037/depression-and-patient-reported-outcomes-following-total-shoulder-arthroplasty
#9
Brian C Werner, Alexandra C Wong, Brenda Chang, Edward V Craig, David M Dines, Russell F Warren, Lawrence V Gulotta
BACKGROUND: Recent studies have found that depression is associated with increased pain and impairment following lower-extremity arthroplasty; however, this association has not been investigated for total shoulder arthroplasty. The objective of this study was to investigate the association between depression and patient-reported outcomes following total shoulder arthroplasty. METHODS: A prospectively collected institutional registry was queried for consecutive patients who underwent total shoulder arthroplasty for osteoarthritis from 2007 to 2013 with baseline and minimum 2-year postoperative American Shoulder and Elbow Surgeons (ASES) scores...
April 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28417234/central-lumbar-spinal-stenosis-natural-history-of-non-surgical-patients
#10
Per Wessberg, Karin Frennered
PURPOSE: The aim of the present study was to examine the natural history in patients with lumbar spinal stenosis. The incidence of surgery for this condition has increased considerably during the past decades in spite of a fairly favorable natural history in previous studies. METHODS: 146 consecutive patients with clinical signs and image findings of lumbar spinal stenosis, who were not recommended surgical treatment, were followed; the reason as to why surgery was not recommended was a moderate symptom level...
April 17, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28412060/minimum-2-year-outcomes-of-arthroscopic-management-of-symptomatic-hip-labrum-tears-in-patients-with-global-acetabular-overcoverage
#11
Sivashankar Chandrasekaran, Nader Darwish, Mary R Close, Carlos Suarez-Ahedo, Parth Lodhia, Benjamin G Domb
PURPOSE: To report minimum 2-year patient-reported outcomes (PROs) after hip arthroscopy (HA) for symptomatic labral tears in patients with global acetabular overcoverage. METHODS: This study was a retrospective case series of patients who underwent HA from April 2008 to April 2013. The inclusion criteria were patients with global acetabular overcoverage, defined as a lateral center-edge angle greater than 40°, and with coxa profunda, defined radiologically by the ilioischial line lateral to the acetabular floor...
April 12, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28407720/cross-cultural-adaptation-and-validation-of-the-arabic-version-of-the-knee-outcome-survey-activities-for-daily-living-scale
#12
Fawzi F Bouzubar, Sameera H Aljadi, Naser M Alotaibi, James J Irrgang
PURPOSE: The purpose of this study is to cross-culturally adapt the Knee Outcome Survey-Activities of Daily Living Scale into Arabic and to assess its psychometric properties (internal consistency, reliability, validity, and responsiveness) in patients with knee disorders. METHODS: The cross-cultural adaptation process for the Knee Outcome Survey-Activities of Daily Living Scale into Arabic was performed consistent with the published guidelines. The psychometric properties of this Arabic version were then evaluated...
April 14, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28402245/thyroid-hormone-therapy-for-older-adults-with-subclinical-hypothyroidism
#13
David J Stott, Nicolas Rodondi, Patricia M Kearney, Ian Ford, Rudi G J Westendorp, Simon P Mooijaart, Naveed Sattar, Carole E Aubert, Drahomir Aujesky, Douglas C Bauer, Christine Baumgartner, Manuel R Blum, John P Browne, Stephen Byrne, Tinh-Hai Collet, Olaf M Dekkers, Wendy P J den Elzen, Robert S Du Puy, Graham Ellis, Martin Feller, Carmen Floriani, Kirsty Hendry, Caroline Hurley, J Wouter Jukema, Sharon Kean, Maria Kelly, Danielle Krebs, Peter Langhorne, Gemma McCarthy, Vera McCarthy, Alex McConnachie, Mairi McDade, Martina Messow, Annemarie O'Flynn, David O'Riordan, Rosalinde K E Poortvliet, Terence J Quinn, Audrey Russell, Carol Sinnott, Jan W A Smit, H Anette Van Dorland, Kieran A Walsh, Elaine K Walsh, Torquil Watt, Robbie Wilson, Jacobijn Gussekloo
Background The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. Methods We conducted a double-blind, randomized, placebo-controlled, parallel-group trial involving 737 adults who were at least 65 years of age and who had persisting subclinical hypothyroidism (thyrotropin level, 4.60 to 19.99 mIU per liter; free thyroxine level within the reference range). A total of 368 patients were assigned to receive levothyroxine (at a starting dose of 50 μg daily, or 25 μg if the body weight was <50 kg or the patient had coronary heart disease), with dose adjustment according to the thyrotropin level; 369 patients were assigned to receive placebo with mock dose adjustment...
April 3, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28400760/aeromonas-diversity-and-antimicrobial-susceptibility-in-freshwater-an-attempt-to-set-generic-epidemiological-cut-off-values
#14
Sandrine Baron, Sophie A Granier, Emeline Larvor, Eric Jouy, Maelan Cineux, Amandine Wilhelm, Benoit Gassilloud, Sophie Le Bouquin, Isabelle Kempf, Claire Chauvin
The importance of the role of environment in the dissemination of antimicrobial resistant bacteria is now well recognized. Thus, bacterial indicators to monitor the phenomena are required. The Aeromonas genus is autochthonous in the aquatic environment and easy to detect in any water type, such as freshwater, or wastewater. These microorganisms are also causing infections in humans and animals (including fish). Furthermore, as Aeromonas spp. is able to acquire antimicrobial resistance mechanisms, it is candidate for indicator bacteria to follow antimicrobial resistance dissemination in aquatic environments...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28394084/personalised-asthma-action-plans-for-adults-with-asthma
#15
REVIEW
Timothy L Gatheral, Alison Rushton, David Jw Evans, Caroline A Mulvaney, Nathan R Halcovitch, Gemma Whiteley, Fiona Jr Eccles, Sally Spencer
BACKGROUND: A key aim of asthma care is to empower each person to take control of his or her own condition. A personalised asthma action plan (PAAP), also known as a written action plan, an individualised action plan, or a self-management action plan, contributes to this endeavour. A PAAP includes individualised self-management instructions devised collaboratively with the patient to help maintain asthma control and regain control in the event of an exacerbation. A PAAP includes baseline characteristics (such as lung function), maintenance medication and instructions on how to respond to increasing symptoms and when to seek medical help...
April 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28365600/dental-students-clinical-experience-across-three-successive-curricula-at-one-u-s-dental-school
#16
COMPARATIVE STUDY
Joel M White, Larry E Jenson, Stuart A Gansky, Cameron J Walsh, Brent T Accurso, Ram M Vaderhobli, Elsbeth Kalenderian, Muhammad F Walji, Jing Cheng
As dental schools continue to seek the most effective ways to provide clinical education for students, it is important to track the effects innovations have on students' clinical experience to allow for quantitative comparisons of various curricula. The aim of this study was to compare the impact of three successive clinical curricula on students' experience at one U.S. dental school. The three were a discipline-based curriculum (DBC), a comprehensive care curriculum (CCC), and a procedural requirement curriculum plus externships (PRCE)...
April 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28362239/associations-between-clinical-outcome-and-navigated-transcranial-magnetic-stimulation-characteristics-in-patients-with-motor-eloquent-brain-lesions-a-combined-navigated-transcranial-magnetic-stimulation-diffusion-tensor-imaging-fiber-tracking-approach
#17
Nico Sollmann, Noémie Wildschuetz, Anna Kelm, Neal Conway, Tobias Moser, Lucia Bulubas, Jan S Kirschke, Bernhard Meyer, Sandro M Krieg
OBJECTIVE Navigated transcranial magnetic stimulation (nTMS) and diffusion tensor imaging fiber tracking (DTI FT) based on nTMS data are increasingly used for preoperative planning and resection guidance in patients suffering from motor-eloquent brain tumors. The present study explores whether nTMS-based DTI FT can also be used for individual preoperative risk assessment regarding surgery-related motor impairment. METHODS Data derived from preoperative nTMS motor mapping and subsequent nTMS-based tractography in 86 patients were analyzed...
March 31, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28362212/does-clinical-improvement-of-symptomatic-degenerative-lumbar-disease-impact-obesity
#18
Jacob R Joseph, Zishaan Farooqui, Brandon W Smith, Elyne N Kahn, Xilin Liu, Frank La Marca, Paul Park
OBJECTIVE Obesity and low-back pain associated with degenerative spondylosis or spondylolisthesis are common comorbid conditions. Many patients report that the pain and disability associated with degenerative lumbar disease are key factors in their inability to lose weight. The aim of this retrospective study was to determine if there is an association between improved functional status and weight loss following a successful transforaminal lumbar interbody fusion (TLIF) procedure. METHODS A retrospective cohort study of patients who underwent single-level TLIF was performed...
March 31, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28362188/spinal-column-shortening-for-tethered-cord-syndrome-associated-with-myelomeningocele-lumbosacral-lipoma-and-lipomyelomeningocele-in-children-and-young-adults
#19
Guillermo Aldave, Daniel Hansen, Steven W Hwang, Amee Moreno, Valentina Briceño, Andrew Jea
OBJECTIVE Tethered cord syndrome is the clinical manifestation of an abnormal stretch on the spinal cord, presumably causing mechanical injury, a compromised blood supply, and altered spinal cord metabolism. Tethered cord release is the standard treatment for tethered cord syndrome. However, direct untethering of the spinal cord carries potential risks, such as new neurological deficits from spinal cord injury, a CSF leak from opening the dura, and retethering of the spinal cord from normal scar formation after surgery...
March 31, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28357679/changes-in-quality-of-life-after-elective-surgery-an-observational-study-comparing-two-measures
#20
Vanessa L Kronzer, Michelle R Jerry, Arbi Ben Abdallah, Troy S Wildes, Sherry L McKinnon, Anshuman Sharma, Michael S Avidan
PURPOSE: Our main objective was to compare the change in a validated quality of life measure to a global assessment measure. The secondary objectives were to estimate the minimum clinically important difference (MCID) and to describe the change in quality of life by surgical specialty. METHODS: This prospective cohort study included 7902 adult patients undergoing elective surgery. Changes in the Veterans RAND 12-Item Health Survey (VR-12), composed of a physical component summary (PCS) and a mental component summary (MCS), were calculated using preoperative and postoperative questionnaires...
March 29, 2017: Quality of Life Research
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