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Minimum clinically important difference

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https://www.readbyqxmd.com/read/28210464/evaluation-of-efflux-pumps-gene-expression-in-resistant-pseudomonas-aeruginosa-isolates-in-an-iranian-referral-hospital
#1
Babak Pourakbari, Sahar Yaslianifard, Somaye Yaslianifard, Shima Mahmoudi, Sepideh Keshavarz-Valian, Setareh Mamishi
BACKGROUND AND OBJECTIVES: Pseudomonas aeruginosa (PA) is one of the most important causes of nosocomial infections and has an intrinsic resistance to many antibiotics. Among all the resistance-nodulation-division (RND) pumps of P. aeruginosa, MexAB-OprM is the first efflux pump found to target multiple classes of antibiotics. This study was aimed to evaluate the expression level of genes expressing MexAB-OprM in clinical isolates of P. aeruginosa. MATERIALS AND METHODS: In this study, 45 P...
August 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28196255/effect-of-2-years-of-treatment-with-sublingual-grass-pollen-immunotherapy-on-nasal-response-to-allergen-challenge-at-3-years-among-patients-with-moderate-to-severe-seasonal-allergic-rhinitis-the-grass-randomized-clinical-trial
#2
Guy W Scadding, Moises A Calderon, Mohamed H Shamji, Aarif O Eifan, Martin Penagos, Florentina Dumitru, Michelle L Sever, Henry T Bahnson, Kaitie Lawson, Kristina M Harris, Audrey G Plough, Joy Laurienzo Panza, Tielin Qin, Noha Lim, Nadia K Tchao, Alkis Togias, Stephen R Durham
Importance: Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following discontinuation of treatment. Objective: To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placebo, provides improved nasal response to allergen challenge at 3-year follow-up...
February 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28194525/low-dose-solumatrix-diclofenac-in-patients-with-osteoarthritis-pain-impact-on-quality-of-life-in-a-controlled-trial
#3
Vibeke Strand, Martin Bergman, Jasvinder A Singh, Allan Gibofsky, Alan Kivitz, Clarence Young
Low-dose SoluMatrix diclofenac was developed to provide effective pain relief for osteoarthritis pain. We evaluated the effects of SoluMatrix diclofenac on health-related quality of life (HRQoL) measures in patients with osteoarthritis, hypothesizing that SoluMatrix-treated patients would experience significant improvement compared with placebo. In this 12-week, phase 3 randomized controlled trial, 305 patients with osteoarthritis of the hip or knee received SoluMatrix diclofenac 35 mg three times (TID) or twice (BID) daily or placebo...
February 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28185242/long-acting-muscarinic-antagonist-lama-plus-long-acting-beta-agonist-laba-versus-laba-plus-inhaled-corticosteroid-ics-for-stable-chronic-obstructive-pulmonary-disease-copd
#4
REVIEW
Nobuyuki Horita, Atsushi Goto, Yuji Shibata, Erika Ota, Kentaro Nakashima, Kenjiro Nagai, Takeshi Kaneko
BACKGROUND: Three classes of inhaler medications are used to manage chronic obstructive pulmonary disease (COPD): long-acting beta-agonists (LABA), long-acting muscarinic antagonists (LAMA), and inhaled corticosteroids (ICS). When two classes of medications are required, LAMA plus LABA (LAMA+LABA) and LABA plus ICS (LABA+ICS) are often selected because these combinations can be administered via a single medication device. The previous Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidance recommended LABA+ICS as the first-line treatment for managing stable COPD in high-risk people of categories C and D...
February 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28174564/commiphora-leptophloeos-phytochemical-and-antimicrobial-characterization
#5
Jorge J de Souza Pereira, Aline de P C Pereira, Jannyson J B Jandú, Josinete A da Paz, Sergio Crovella, Maria T Dos Santos Correia, Jaqueline de Azevêdo Silva
Commiphora leptophloeos is a plant specie usually known for its medicinal purposes in local communities in Northeast Brazil. In order to evaluate its therapeutic potential, we aimed to determine the phytochemical and antimicrobial properties of C. leptophloeos extracts. Thin Layer Chromatography (TLC) was able to detect the presence of phenolic compounds, flavonoids and reducing sugars. Three phenolic compounds were identified by HPLC and described as Gallic, Chlorogenic and Protocatechuic acids. On the other hand, H(1)NMR analysis revealed the presence of hinokinin, a bioactive lignan further characterized in the present work...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28159362/fungicidal-efficacy-of-various-honeys-against-fluconazole-resistant-candida-species-isolated-from-hiv-patients-with-candidiasis
#6
H Shokri, A Sharifzadeh
OBJECTIVE: Honey is well known to possess a broad spectrum of activity against medically important organisms. The purpose of this study was to assess the antifungal activity of different honeys against 40 fluconazole (FLU) resistant Candida species, including Candida albicans (C. albicans), Candida glabrata, Candida krusei and Candida tropicalis. MATERIALS AND METHODS: Three honey samples were collected from northern (Mazandaran, A), southern (Hormozgan, B) and central (Lorestan, C) regions of Iran...
January 31, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28156493/oncology-supportive-care-clinics-as-a-novel-model-to-integrate-oncology-and-palliative-care
#7
Neha Damle, John D Greene, Jennifer M Baker, Esther J Luo, Gabriel J Escobar
: 154 Background: The integration of oncology with palliative care (PC) has been endorsed by the American Society of Clinical Oncology. Starting in 2012, Kaiser Permanente Northern California (KPNC) began introducing Oncology Supportive Care Clinics (OSCCs) to better provide integrated oncology and PC services. We evaluated the impact of OSCCs on outpatient PC referrals among patients diagnosed with advanced cancers. METHODS: We included all adult patients diagnosed with incidental stage IV cancer from 2010-2014 from 19 medical centers within KPNC...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28154373/effect-of-tiotropium-and-olodaterol-on-symptoms-and-patient-reported-outcomes-in-patients-with-copd-results-from-four-randomised-double-blind-studies
#8
Gary T Ferguson, Jill Karpel, Nathan Bennett, Emmanuelle Clerisme-Beaty, Lars Grönke, Florian Voß, Roland Buhl
: Chronic obstructive pulmonary disease is associated with significant morbidity and mortality. Trials of maintenance chronic obstructive pulmonary disease treatments focus on improvement in lung function and reductions in exacerbations, while patients are much more concerned about symptoms and health status. Our aim was to investigate the effects of tiotropium + olodaterol on patient-reported health outcomes, breathlessness and night-time rescue medication use in patients with chronic obstructive pulmonary disease, compared to placebo, tiotropium or olodaterol monotherapy...
December 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28149463/a-cone-beam-computed-tomography-cbct-evaluation-of-mb2-canals-in-endodontically-treated-permanent-maxillary-molars-a-retrospective-study-in-indian-population
#9
Heeresh Shetty, Subodh Sontakke, Freny Karjodkar, Pankaj Gupta, Ashish Mandwe, K S Banga
BACKGROUND: Current technological advances have allowed application of different study designs and techniques for investigation of dental anatomy. Some clinical studies have provided evidence that Cone Beam computed tomography (CBCT) scanning is an important resource in assessment of root canal systems notably to identify MB2 canals in maxillary molars as CBCT scans allow in vivo dental investigation in axial, sagittal and coronal planes simultaneously. The current study was undertaken to detect and evaluate filled/unfilled MB2 canals in endodontically treated, asymptomatic maxillary molars utilizing cone beam computed tomography (CBCT)...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28146018/need-for-two-year-patient-reported-outcomes-score-for-lumbar-spine-surgery-is-procedure-specific-analysis-from-a-prospective-longitudinal-spine-registry
#10
Elliott J Kim, Silky Chotai, Kristin R Archer, Mohamad Bydon, Anthony L Asher, Clinton J Devin
STUDY DESIGN: Retrospective analysis of prospectively collected data OBJECTIVE.: The aim of this study was to determine whether 1-year patient-reported outcomes (PROs) can accurately assess effective care for patients undergoing surgery for degenerative lumbar spine disease SUMMARY OF BACKGROUND DATA.: Prospective longitudinal PROs registries provide a means to accurately assess outcomes and determine the relative effectiveness of various spine treatments. Obtaining long-term PROs can be costly and challenging...
January 31, 2017: Spine
https://www.readbyqxmd.com/read/28144605/limb-lengthening-using-the-precice-tm-nail-system-complications-and-results
#11
Ulrich Wiebking, Emmanouil Liodakis, Mohamed Kenawey, Christian Krettek
BACKGROUND: Three types of telescopic nails are mainly used for intramedullary limb lengthening nowadays. Despite some important advantages of this new technology (e.g. controlled distraction rate, not restricted availability, possibility to perform accordion maneuvers), few articles exist on clinical results and complications after lengthening with the PRECICE(TM) nail (Ellipse, USA). OBJECTIVES: The aim of the current study was to describe and analyze the complications associated with lengthening with the PRECICE(TM) nail...
December 2016: Archives of Trauma Research
https://www.readbyqxmd.com/read/28141840/poor-quality-for-poor-women-inequities-in-the-quality-of-antenatal-and-delivery-care-in-kenya
#12
Jigyasa Sharma, Hannah H Leslie, Francis Kundu, Margaret E Kruk
BACKGROUND: Quality of healthcare is an important determinant of future progress in global health. However, the distributional aspects of quality of care have received inadequate attention. We assessed whether high quality maternal care is equitably distributed by (1) mapping the quality of maternal care in facilities located in poorer versus wealthier areas of Kenya; and (2) comparing the quality of maternal care available to Kenyans in and not in poverty. METHODS: We assessed three measures of maternal care quality: facility infrastructure and clinical quality of antenatal care and delivery care, using indicators from the 2010 Kenya Service Provision Assessment (SPA), a standardized facility survey with direct observation of maternal care provision...
2017: PloS One
https://www.readbyqxmd.com/read/28137476/establishing-the-minimal-clinical-important-difference-and-minimal-detectable-change-for-the-cumberland-ankle-instability-tool
#13
Cynthia J Wright, Shelley W Linens, M Spencer Cain
OBJECTIVE: The objective was to establish the minimal detectable change (MDC) and minimal clinically important different (MCID) for the Cumberland Ankle Instability Tool (CAIT) in a population with chronic ankle instability (CAI). DESIGN: Experimental cohort. SETTING: Laboratory. PARTICIPANTS: A convenience sample of fifty participants with CAI participated (12 males, 38 females, monthly giving-way=5.84±12.54). CAI inclusion criteria included a history of an ankle sprain, recurrent episodes of giving way, and a CAIT score ≤ 25...
January 27, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28132094/unilateral-hearing-loss-in-children-a-retrospective-study-and-a-review-of-the-current-literature
#14
Anna-Katharina Rohlfs, Johannes Friedhoff, Andrea Bohnert, Achim Breitfuss, Markus Hess, Frank Müller, Anke Strauch, Marianne Röhrs, Thomas Wiesner
: Despite the introduction of universal newborn hearing screening (UNHS), unilateral hearing loss (UHL) is sometimes recognized late. This diagnostic delay has adverse repercussions, given the importance of binaural hearing for the development of normal auditory processing. It is incorrect to maintain that unilateral hearing is the minimum requirement for adequate speech development and that hearing aid provision is consequently unnecessary. In our retrospective study, hearing aid provision resulted in improved directional and selective hearing (quiet and noisy environments) and, compared with their chronically ill counterparts, the children in our study displayed superior health-related quality of life (HRQoL) scores in all areas...
January 28, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28124960/-investigation-of-in-vitro-metronidazole-resistance-in-the-clinical-isolates-of-trichomonas-vaginalis
#15
Hatice Ertabaklar, Senem Yaman Karadam, Erdoğan Malatyalı, Sema Ertuğ
Trichomonas vaginalis, a flagellated, urogenital anaerobic protozoon is reported as an important cause of vaginitis with a global distribution. Although metronidazole is the primary choice of drug for the treatment of trichomoniasis, the presence of resistant isolates from many different countries highlights the need of novel drugs for the treatment. Many studies from Turkey mostly dealing with the in vitro effects of compounds and natural products against T.vaginalis have been reported, however, only one study has been encountered searching the metronidazole resistance in a single T...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28124297/editorial-the-minimum-clinically-important-difference-the-least-we-can-do
#16
EDITORIAL
Seth S Leopold, Raphaël Porcher
No abstract text is available yet for this article.
January 25, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28122126/neuroprotection-for-treatment-of-glaucoma-in-adults
#17
REVIEW
Dayse F Sena, Kristina Lindsley
BACKGROUND: Glaucoma is a heterogeneous group of conditions involving progressive damage to the optic nerve, deterioration of retinal ganglion cells, and ultimately visual field loss. It is a leading cause of blindness worldwide. Open angle glaucoma (OAG), the most common form of glaucoma, is a chronic condition that may or may not present with increased intraocular pressure (IOP). Neuroprotection for glaucoma refers to any intervention intended to prevent optic nerve damage or cell death...
January 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28119204/effect-of-walking-speed-in-heart-failure-patients-and-heart-transplant-patients
#18
Renata L Bona, Artur Bonezi, Paula Figueiredo da Silva, Carlo M Biancardi, Flávio Antônio de Souza Castro, Nadine Oliveira Clausel
BACKGROUND: Chronic heart failure patients present higher cost of transport and some changes in pattern of walking, but the same aspects have not yet been investigated in heart transplant patients. METHODS: The aim of this study was to investigate both metabolic and mechanicals parameters, at five different walking speeds on treadmill, in chronic heart failure and heart transplant patients. Twelve chronic heart failure patients, twelve healthy controls and five heart transplant patients participated in the study...
January 16, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28113460/optimum-diffraction-corrected-frequency-shift-estimator-of-the-ultrasonic-attenuation-coefficient
#19
Kayvan Samimi, Tomy Varghese
The ultrasonic attenuation coefficient is an important parameter that has been studied extensively in Quantitative Ultrasound and Tissue Characterization. There are various methods described in the literature that estimate this parameter by measuring either spectral difference (i.e., decay) or spectral shift of the backscattered echo signal. Under ideal conditions, i.e., in the absence of abrupt changes in tissue backscattering, Spectral Difference methods can produce estimates with high accuracy and precision...
March 4, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28113021/fentanyl-sublingual-tablets-versus-subcutaneous-morphine-for-the-management-of-severe-cancer-pain-episodes-in-patients-receiving-opioid-treatment-a-double-blind-randomized-noninferiority-trial
#20
Ernesto Zecca, Cinzia Brunelli, Fabio Centurioni, Andrea Manzoni, Alessandra Pigni, Augusto Caraceni
Purpose Fentanyl sublingual tablets (FST) are a potentially useful alternative to parenteral opioids such as subcutaneous morphine (SCM) to treat severe cancer pain episodes. No direct comparison between FST and SCM is available. The aim of this study was to test noninferiority of FST versus SCM during the first 30 min postadministration. Methods Patients receiving stable opioid therapy and experiencing a severe pain episode were randomly assigned to either 100 µg FST or 5 mg SCM in a double-blind, double-dummy trial...
January 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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