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Minimum clinically important difference

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https://www.readbyqxmd.com/read/27922969/orbital-morphometry-a-computed-tomography-analysis
#1
Jaswinder Singh, Roselinda Ab Rahman, Zainul Ahmad Rajion, Johari Abdullah, Irfan Mohamad
INTRODUCTION: The human orbit is a complex anatomic region, which plays predominant role in the evaluation of craniofacial complex. A thorough understanding of the relationship of the distance from orbital rim to the important vital structures of the orbital apex is required for the surgeon to perform safe and effective surgery. OBJECTIVES: To evaluate and compare the depth and distances from various points of the orbital rim to the fissures and foramina of the orbital apex between genders in the local population...
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27920246/beyond-utilization-measuring-effective-coverage-of-obstetric-care-along-the-quality-cascade
#2
Elysia Larson, Daniel Vail, Godfrey M Mbaruku, Redempta Mbatia, Margaret E Kruk
OBJECTIVE: To determine the effective coverage of obstetric care in a rural Tanzanian region and to assess differences in effective coverage by wealth. DESIGN: Cross-sectional structured interviews. SETTING: Pwani Region, Tanzania. PARTICIPANTS: The study includes 24 rural, government-managed, primary healthcare clinics and their catchment populations. From January-April 2016, we conducted a household survey of a census of women with recent deliveries, health worker knowledge surveys and facility audits...
December 4, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/27903195/dosimetric-effects-of-onyx-embolization-on-gamma-knife-arteriovenous-malformation-dose-distributions
#3
David J Schlesinger, Håkan Nordström, Anders Lundin, Zhiyuan Xu, Jason P Sheehan
OBJECTIVE Patients with arteriovenous malformations (AVMs) treated with Gamma Knife radiosurgery (GKRS) subsequent to embolization suffer from elevated local failure rates and differences in adverse radiation effects. Onyx is a common embolic material for AVMs. Onyx is formulated with tantalum, a high atomic number (Z = 73) element that has been investigated as a source of dosimetric uncertainty contributing to the less favorable clinical results. However, prior studies have not modeled the complicated anatomical and beam geometries characteristic of GKRS...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27903188/the-role-of-diffusion-tensor-imaging-tractography-for-gamma-knife-thalamotomy-planning
#4
João Gabriel Ribeiro Gomes, Alessandra Augusta Gorgulho, Amanda de Oliveira López, Crystian Wilian Chagas Saraiva, Lucas Petri Damiani, Anderson Martins Pássaro, João Victor Salvajoli, Ludmila de Oliveira Siqueira, Bernardo Peres Salvajoli, Antônio Afonso Ferreira De Salles
OBJECTIVE The role of tractography in Gamma Knife thalamotomy (GK-T) planning is still unclear. Pyramidal tractography might reduce the risk of radiation injury to the pyramidal tract and reduce motor complications. METHODS In this study, the ventralis intermedius nucleus (VIM) targets of 20 patients were bilaterally defined using Iplannet Stereotaxy Software, according to the anterior commissure-posterior commissure (AC-PC) line and considering the localization of the pyramidal tract. The 40 targets and tractography were transferred as objects to the GammaPlan Treatment Planning System (GP-TPS)...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27891528/preparing-nursing-home-data-from-multiple-sites-for-clinical-research-a-case-study-using-observational-health-data-sciences-and-informatics
#5
Richard D Boyce, Steven M Handler, Jordan F Karp, Subashan Perera, Charles F Reynolds
INTRODUCTION: A potential barrier to nursing home research is the limited availability of research quality data in electronic form. We describe a case study of converting electronic health data from five skilled nursing facilities to a research quality longitudinal dataset by means of open-source tools produced by the Observational Health Data Sciences and Informatics (OHDSI) collaborative. METHODS: The Long-Term Care Minimum Data Set (MDS), drug dispensing, and fall incident data from five SNFs were extracted, translated, and loaded into version 4 of the OHDSI common data model...
2016: EGEMS
https://www.readbyqxmd.com/read/27885285/emergence-of-aminoglycoside-resistance-due-to-arma-methylase-in-multi-drug-resistant-acinetobacter-baumannii-isolates-in-a-university-hospital-in-nepal
#6
S Shrestha, T Tada, B Shrestha, T Kirikae, H Ohara, B P Rijal, B M Pokhrel, J B Sherchand
BACKGROUND: The emergence of multidrug-resistant Acinetobacter baumannii associated with hospital-acquired infections has been increasingly reported worldwide. 16S rRNA methylase producing Gram-negative bacteria are highly resistant to all clinically important aminoglycosides. We analyzed A. baumannii clinical isolates resistant to aminoglycosides from hospitalized patients. The objective of this study was to investigate the emergence of armA in A.baumannii species associated with nosocomial infection in a university hospital in Nepal...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27875412/preoperative-mental-health-is-not-predictive-of-patient-reported-outcomes-following-a-minimally-invasive-lumbar-discectomy
#7
Benjamin C Mayo, Dustin H Massel, Daniel D Bohl, William W Long, Krishna D Modi, Ankur S Narain, Fady Y Hijji, Gregory Lopez, Kern Singh
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To determine if preoperative mental health is associated with patient-reported outcomes (PROs) following a minimally invasive lumbar discectomy. SUMMARY OF BACKGROUND DATA: PROs are commonly used to quantify a patient's perceived health status. Recently, mental health has been theorized to directly affect patients' perception of their disability and pain after spine surgery. MATERIALS AND METHODS: A registry of patients who underwent a primary, single-level minimally invasive lumbar discectomy was reviewed...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27873342/inconsistency-and-drop-minimum-data-analysis
#8
Fei Chen, Gang Li, K K Gordon Lan
Even though consistency is an important issue in multi-regional clinical trials and inconsistency is often anticipated, solutions for handling inconsistency are rare. If a region's treatment effects are inconsistent with that of the other regions, pooling all the regions to estimate the overall treatment effect may not be reasonable. Unlike the multiple center clinical trials conducted in the USA and Europe, in multi-regional clinical trials, different regional regulatory agencies may have their own ways to interpret data and approve new drugs...
November 21, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27872073/exploring-the-role-of-the-%C3%AE-loop-in-the-evolution-of-ceftazidime-resistance-in-the-pena-%C3%AE-lactamase-from-burkholderia-multivorans-an-important-cystic-fibrosis-pathogen
#9
Krisztina M Papp-Wallace, Scott A Becka, Magdalena A Taracila, Elise T Zeiser, Julian A Gatta, John J LiPuma, Robert A Bonomo
The unwelcome evolution of resistance to the advanced generation cephalosporin antibiotic, ceftazidime is hindering the effective therapy of Burkholderia cepacia complex (Bcc) infections. Regrettably, Bcc are highly resistant to most antibiotics, including polymyxins; ceftazidime and trimethoprim-sulfamethoxazole are the most effective treatment options. Unfortunately, resistance to ceftazidime is increasing and posing a health threat to populations susceptible to Bcc infection. We found that up to 36% of 146 tested Bcc clinical isolates were non-susceptible to ceftazidime...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27870805/minimum-clinically-important-difference-current-trends-in-the-spine-literature
#10
Andrew S Chung, Anne Copay, Neil Olmscheid, David Campbell, Brock Walker, Norman Chutkan
STUDY DESIGN: Review of the 2011-2015 minimum clinically important difference (MCID)-related publications in Spine, Spine Journal, Journal of Neurosurgery-Spine, and European Spine Journal. OBJECTIVE: To summarize the various determinations of MCID and to analyze its usage in the spine literature of the past 5 years in order to develop a basic reference to help practitioners interpret or utilize MCID. SUMMARY OF BACKGROUND DATA: MCID represents the smallest change in a domain of interest that is considered beneficial to a patient or clinician...
November 18, 2016: Spine
https://www.readbyqxmd.com/read/27851857/assessing-the-efficacy-and-safety-of-eravacycline-vs-ertapenem-in-complicated-intra-abdominal-infections-in-the-investigating-gram-negative-infections-treated-with-eravacycline-ignite-1-trial-a-randomized-clinical-trial
#11
Joseph Solomkin, David Evans, Algirdas Slepavicius, Patrick Lee, Andrew Marsh, Larry Tsai, Joyce A Sutcliffe, Patrick Horn
Importance: Eravacycline is a novel, fully synthetic fluorocycline antibiotic of the tetracycline class with in vitro activity against clinically important gram-negative, gram-positive aerobic, and facultative bacteria including most of those resistant to cephalosporins, fluoroquinolones, β-lactam/β-lactamase inhibitors, multidrug resistant strains and carbapenem-resistant Enterobacteriaceae, and most anaerobic pathogens. Objective: To evaluate the efficacy and safety of eravacycline compared with ertapenem in adult hospitalized patients with complicated intra-abdominal infections (cIAIs)...
November 16, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27846837/prevalence-aetiology-treatment-and-outcomes-of-shock-in-children-admitted-to-kenyan-hospitals
#12
George Mbevi, Philip Ayieko, Grace Irimu, Samuel Akech, Mike English
BACKGROUND: Shock may complicate several acute childhood illnesses in hospitals within low-income countries and has a high case fatality. Hypovolemic shock secondary to diarrhoea/dehydration and septic shock are thought to be common, but there are few reliable data on prevalence or treatment that differ for the two major forms of shock. Examining prevalence and treatment practices has become important since reports suggest high risks from liberal use of fluid boluses in African children...
November 16, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27842872/first-detection-of-extended-spectrum-cephalosporin-and-fluoroquinolone-resistant-escherichia-coli-in-australian-food-producing-animals
#13
Sam Abraham, David Jordan, Hui S Wong, James R Johnson, Mark A Toleman, David L Wakeham, David M Gordon, John D Turnidge, Joanne L Mollinger, Justine S Gibson, Darren J Trott
This study aimed to define the frequency of resistance to critically important antimicrobials (CIAs) [i.e. extended-spectrum cephalosporins (ESCs), fluoroquinolones (FQs) and carbapenems] among Escherichia coli isolates causing clinical disease in Australian food-producing animals. Clinical E. coli isolates (n=324) from Australian food-producing animals [cattle (n=169), porcine (n=114), poultry (n=32) and sheep (n=9)] were compiled from all veterinary diagnostic laboratories across Australia over a 1-year period...
December 2015: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27802963/does-the-chronicity-of-anterior-cruciate-ligament-ruptures-influence-patient-reported-outcomes-before-surgery
#14
Joseph T Nguyen, David Wasserstein, Emily K Reinke, Kurt P Spindler, Nabil Mehta, John B Doyle, Robert G Marx
BACKGROUND: The time between an anterior cruciate ligament (ACL) injury and ACL reconstruction (ACLR) may influence baseline knee-related and general health-related patient-reported outcome measures (PROMs). Despite the common use of PROMs as main outcomes in clinical studies, this variable has never been evaluated. PURPOSE: To compare baseline health-related quality of life measures and the prevalence/pattern of meniscal and articular cartilage lesions between patients who underwent acute and chronic ACLR so as to provide clinicians with benchmark PROMs in 2 different patient populations with ACL injuries...
November 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27793184/identifying-placebo-responders-and-predictors-of-response-in-osteoarthritis-a-protocol-for-individual-patient-data-meta-analysis
#15
Yu Fu, Monica S M Persson, Archan Bhattacharya, Siew-Li Goh, Joanne Stocks, Marienke van Middelkoop, Sita M A Bierma-Zeinstra, David Walsh, Michael Doherty, Weiya Zhang
BACKGROUND: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical trials can be attributed to a placebo response, and this response varies greatly from patient to patient. This individual patient data (IPD) meta-analysis aims to identify placebo responders and the potential determinants of the placebo response in OA...
October 28, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27792107/minimum-clinically-important-difference-and-substantial-clinical-benefit-in-pain-functional-and-quality-of-life-scales-in-failed-back-surgery-syndrome-patients
#16
Ki Byung Park, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Jun-Hwan Lee, Kyung-Min Shin, Byung-Cheul Shin, Jae-Heung Cho, In-Hyuk Ha
STUDY DESIGN: Prospective observational 1-year study OBJECTIVE.: To determine minimum clinically important difference (MCID) and substantial clinical benefit (SCB) of outcome measures in failed back surgery syndrome (FBSS) patients, as these metrics enable assessment of whether and when an intervention produces clinically meaningful effects in a patient SUMMARY OF BACKGROUND DATA.: Several methods have been devised to quantify clinically important difference, but MCID and SCB for FBSS patients has yet to be determined...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27789239/minimal-clinically-important-difference-of-berg-balance-scale-in-people-with-multiple-sclerosis
#17
Elisa Gervasoni, Johanna Jonsdottir, Angelo Montesano, Davide Cattaneo
OBJECTIVE: To identify the Minimal Clinically Important Difference (MCID) to define clinically meaningful patient's improvement on the Berg Balance Scale (BBS) in People with Multiple Sclerosis (PwMS) in response to rehabilitation. DESIGN: Cohort study SETTING: Neurorehabilitation institute. PARTICIPANTS: 110 PwMS participated in this study. INTERVENTIONS: This study is comprised of inpatients and outpatients that participated in research on balance and gait rehabilitation...
October 24, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27783268/fixed-dose-combination-inhalers
#18
Mario Cazzola, Maria Gabriella Matera
In asthma and chronic obstructive pulmonary disease (COPD), an important step in simplifying management and improving adherence with prescribed therapy is to reduce the dose frequency to the minimum necessary to maintain disease control. Fixed-dose combination (FDC) therapy might enhance compliance by decreasing the number of medications and/or the number of daily doses. Furthermore, they have the potential for enhancing, sensitizing, and prolonging the effects of monocomponents. Combination therapy with an inhaled corticosteroid (ICS) and a long-acting β-agonist (LABA) is considered an important approach for treating patients with asthma and patients with severe COPD who have frequent exacerbations...
October 26, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27782687/assessing-task-performance-in-ffdm-dbt-and-synthetic-mammography-using-uniform-and-anthropomorphic-physical-phantoms
#19
Lynda C Ikejimba, Stephen J Glick, Kingshuk Roy Choudhury, Ehsan Samei, Joseph Y Lo
PURPOSE: The purpose of this study is to quantify the differences in detectability between full field digital mammography (FFDM), digital breast tomosynthesis (DBT), and synthetic mammography (SM) for challenging, low contrast signals, in the context of both a uniform and an anthropomorphic, textured phantom. METHODS: Images of the phantoms were acquired using a Hologic Selenia Dimensions system. Images were taken at 50%, 100%, and 200% of the dose delivered under automatic exposure control (AEC)...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27779811/biofilm-formation-and-antimicrobial-susceptibility-of-staphylococci-and-enterococci-from-osteomyelitis-associated-with-percutaneous-orthopaedic-implants
#20
Magdalena Zaborowska, Jonatan Tillander, Rickard Brånemark, Lars Hagberg, Peter Thomsen, Margarita Trobos
Staphylococci and enterococci account for most deep infections associated with bone-anchored percutaneous implants for amputation treatment. Implant-associated infections are difficult to treat; therefore, it is important to investigate if these infections have a biofilm origin and to determine the biofilm antimicrobial susceptibility to improve treatment strategies. The aims were: (i) to test a novel combination of the Calgary biofilm device and a custom-made susceptibility MIC plate (Sensititre(®) ), (ii) to determine the biofilm formation and antimicrobial resistance in clinical isolates causing implant-associated osteomyelitis, and (iii) to describe the associated clinical outcome...
October 25, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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