keyword
MENU ▼
Read by QxMD icon Read
search

Minimum clinically important difference

keyword
https://www.readbyqxmd.com/read/29771855/does-multimodal-rehabilitation-for-ankle-instability-improve-patients-self-assessed-functional-outcomes-a-network-meta-analysis
#1
Konstantinos Tsikopoulos, Dimitris Mavridis, Dimitrios Georgiannos, Haris S Vasiliadis
BACKGROUND: Although there are many nonsurgical treatment options for the primary management of chronic ankle instability, the most effective nonoperative intervention has not been defined. QUESTIONS/PURPOSES: The purpose of this study was to perform a network meta-analysis to compare the results of different standalone and/or combined nonsurgical interventions on chronic ankle instability as measured by (1) the Cumberland Ankle Instability Tool (CAIT) at 0 to 6 months after treatment and (2) treatment-related complications...
June 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29751849/effect-of-continuous-compression-stimulation-on-pressure-pain-threshold-and-muscle-spasms-in-older-adults-with-knee-osteoarthritis-a-randomized-trial
#2
Ryo Tanaka, Takuya Umehara, Yuuki Kawabata, Tomohiko Sakuda
OBJECTIVE: The purpose of this study was to assess the effect of continuous compression stimulation on pressure-pain threshold and muscle spasms in older adults with knee osteoarthritis. METHODS: Thirty-two older adults with knee osteoarthritis on outpatient visits were randomly divided into 2 groups. Those in the treatment group (n = 16) received 5-minute massage therapy (continuous compression stimulation), and those in the control group (n = 16) received sham massage therapy (touch without compression)...
May 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29749912/comparative-durability-and-costs-analysis-of-ventricular-shunts
#3
Nitin Agarwal, Ahmed Kashkoush, Michael M McDowell, William R Lariviere, Naveed Ismail, Robert M Friedlander
OBJECTIVE Ventricular shunt (VS) durability has been well studied in the pediatric population and in patients with normal pressure hydrocephalus; however, further evaluation in a more heterogeneous adult population is needed. This study aims to evaluate the effect of diagnosis and valve type-fixed versus programmable-on shunt durability and cost for placement of shunts in adult patients. METHODS The authors retrospectively reviewed the medical records of all patients who underwent implantation of a VS for hydrocephalus at their institution over a 3-year period between August 2013 and October 2016 with a minimum postoperative follow-up of 6 months...
May 11, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29746963/patient-phenotypes-associated-with-outcome-following-surgery-for-mild-degenerative-cervical-myelopathy-a-principal-component-regression-analysis
#4
Jetan H Badhiwala, Christopher Witiw, Farshad Nassiri, Blessing Jaja, Muhammad A Akbar, Alireza Mansouri, Zamir Merali, George M Ibrahim, Jefferson R Wilson, Michael G Fehlings
BACKGROUND CONTEXT: Predictors of outcome after surgery for degenerative cervical myelopathy (DCM) have been determined previously through hypothesis-driven multivariate statistical models that rely on a priori knowledge of potential confounders, exclude potentially important variables due to restrictions in model building, cannot include highly collinear variables in the same model, and ignore intrinsic correlations among variables. PURPOSE: To apply a data-driven approach to identify patient phenotypes that may predict outcomes after surgery for mild DCM...
May 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29739634/mindfulness-based-exposure-and-response-prevention-for-obsessive-compulsive-disorder-findings-from-a-pilot-randomised-controlled-trial
#5
Clara Strauss, Laura Lea, Mark Hayward, Elizabeth Forrester, Tamara Leeuwerik, Anna-Marie Jones, Claire Rosten
BACKGROUND: Only about half of people with obsessive compulsive disorder (OCD) show clinically significant improvement following the recommended therapy, exposure and response prevention (ERP), partly due to poor therapy acceptability. A mindfulness-based approach to ERP (MB-ERP) has the potential to improve acceptability and outcomes. METHODS: This was an internal pilot randomised controlled trial (RCT) of group MB-ERP compared to group ERP. 37 participants meeting DSM-IV OCD criteria were randomly allocated to MB-ERP or ERP...
April 30, 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29738299/perception-of-diabetic-foot-ulcers-among-general-practitioners-in-four-european-countries-knowledge-skills-and-urgency
#6
José Luis Garcia-Klepzig, Juan Pedro Sánchez-Ríos, Chris Manu, Raju Ahluwalia, Claas Lüdemann, Marco Meloni, Elisabetta Lacopi, Víctor Rodriguez-Saenz De Buruaga, Benjamin Bouillet, Julien Vouillarmet, Jose Luis Lazaro Martinez, Kristien Van Acker
OBJECTIVE: Diabetic foot ulcers (DFU) have the potential to deteriorate rapidly, in the absence of prompt assessment and treatment. The aim of this study was to analyse the awareness and perception of DFU among general practitioners (GPs) from four European countries, and to find possible differences between these countries in terms of management. METHOD: A two-part, quantitative, online questionnaire was distributed to GPs across four countries in Europe-the UK, France, Germany and Spain...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29733680/change-in-koos-and-womac-scores-in-a-young-athletic-population-with-and-without-anterior-cruciate-ligament-injury
#7
Ivan J Antosh, Steven J Svoboda, Karen Y Peck, E'Stephan J Garcia, Kenneth L Cameron
BACKGROUND: Several studies have examined changes in patient-reported outcome measures (PROMs) after anterior cruciate ligament (ACL) injury, but no studies to date have prospectively evaluated changes from preinjury baseline through injury and follow-up among ACL-injured patients compared to the baseline and follow-up changes of uninjured patients. PURPOSE: To examine changes in PROMs over time from preinjury baseline to at least 2 years after ACL reconstruction and to compare these changes with those of an uninjured control group having similar physical activity requirements...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29730138/establishing-maximal-medical-improvement-after-anatomic-total-shoulder-arthroplasty
#8
REVIEW
Richard N Puzzitiello, Avinesh Agarwalla, Joseph N Liu, Gregory L Cvetanovich, Anthony A Romeo, Brian Forsythe, Nikhil N Verma
BACKGROUND: As a heightened emphasis continues to be placed on value-based health care, quality outcomes following orthopedic procedures must be properly defined. With knowledge of the time to maximal medical improvement following total shoulder arthroplasty (TSA), physician resources can be justly allocated to optimize value in ambulatory orthopedic care. MATERIALS AND METHODS: A systematic review was conducted to identify studies reporting sequential follow-up at several time points, up to a minimum of 2 years after TSA...
May 2, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29729942/performance-of-the-asthma-impact-on-quality-of-life-scale-a-iqols-in-diverse-asthma-research-populations-and-demographic-sub-groups
#9
Sandra R Wilson, Robert A Wise, Mario Castro, Michael J Mulligan, Estela Ayala, Alan Chausow, Qiwen Huang, Santosh Gummidipundi
BACKGROUND: The Asthma Impact on Quality of Life Scale (A-IQOLS) assesses patient-perceived negative effect of asthma on quality of life (QoL). Its standard error of measurement is known, it has strong construct, convergent, and divergent validity, and provides information that is unique among asthma outcome measures. OBJECTIVE: To characterize A-IQOLS' psychometric properties and suitability for use in demographically and clinically diverse adult asthma populations...
May 3, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29717974/surveillance-of-antimicrobial-resistance-in-neisseria-meningitidis-strains-isolated-from-invasive-cases-in-brazil-from-2009-to-2016
#10
Maria Cecília Gorla, Juliana Maira Watanabe Pinhata, Ueslei José Dias, Camile de Moraes, Ana Paula Lemos
PURPOSE: To describe the antimicrobial resistance profile of Neisseria meningitidis isolates causing invasive disease in Brazil from 2009 to 2016. METHODOLOGY: Among 3548 N. meningitidis isolates received, 2888 (81.4 %) were analysed for antimicrobial resistance using the broth microdilution technique, as recommended by the Clinical and Laboratory Standards Institute. Isolates were tested for ciprofloxacin, chloramphenicol, ceftriaxone, penicillin G, ampicillin and rifampin...
May 2, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29716492/extended-duration-regional-analgesia-for-total-knee-arthroplasty-a-randomised-controlled-trial-comparing-five-days-to-three-days-of-continuous-adductor-canal-ropivacaine-infusion
#11
S C Sargant, M J Lennon, R J Khan, D Fick, H Robertson, S Haebich
There is a growing body of evidence in favour of continuous adductor canal block (CACB) for total knee arthroplasty. However, there are no studies describing the optimal duration of the infusion. At our institution the usual practice was to stop the infusion on day three. Our hypothesis was that extending the infusion to five days would improve analgesia and quality of recovery. A prospective, non-blinded, randomised trial was undertaken. Patients received a continuous infusion of 0.2% ropivacaine via an adductor canal catheter for either three or five days...
May 2018: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29695943/bosutinib-in-chronic-myeloid-leukemia-patient-selection-and-perspectives
#12
REVIEW
Susanne Isfort, Tim H Brümmendorf
During recent years, the therapeutic landscape in chronic myeloid leukemia (CML) has changed significantly. Since the clinical introduction of tyrosine kinase inhibitors (TKIs) approximately 15 years ago, patients' concerns have shifted from reduced life expectancy toward long-term toxicities of TKI, depth of remission, and the probability of successful treatment discontinuation. Patients with newly diagnosed CML in chronic phase (at least with a Sokal score not exceeding intermediate) may now expect an almost normal life expectancy...
2018: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29695274/a-new-scale-for-the-evaluation-of-clinical-practice-guidelines-applicability-development-and-appraisal
#13
Hui Li, Runsheng Xie, Yangyang Wang, Xiuli Xie, Jingwen Deng, Chuanjian Lu
BACKGROUND: This study aimed to develop the clinical practice guidelines applicability evaluation (CPGAE-V1.0) scale and to evaluate its validity and reliability. METHODS: One hundred fifty assessors were invited to rate two rounds of importance scoring of the applicability indicators by using the 5-point Likert scale. Approved indicators formed the CPGAE-V1.0 scale, consisting of 19 items, arranged into 4 domains. We enrolled eligible clinicians from 8 institutions to evaluate 9 clinical practice guidelines using the CPGAE-V1...
April 25, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29679071/determinants-of-treatment-response-in-first-episode-psychosis-an-18-f-dopa-pet-study
#14
Sameer Jauhar, Mattia Veronese, Matthew M Nour, Maria Rogdaki, Pamela Hathway, Federico E Turkheimer, James Stone, Alice Egerton, Philip McGuire, Shitij Kapur, Oliver D Howes
Psychotic illnesses show variable responses to treatment. Determining the neurobiology underlying this is important for precision medicine and the development of better treatments. It has been proposed that dopaminergic differences underlie variation in response, with striatal dopamine synthesis capacity (DSC) elevated in responders and unaltered in non-responders. We therefore aimed to test this in a prospective cohort, with a nested case-control comparison. 40 volunteers (26 patients with first-episode psychosis and 14 controls) received an 18 F-DOPA Positron Emission Tomography scan to measure DSC (Kicer ) prior to antipsychotic treatment...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29678521/inhibitory-effects-of-drugs-on-the-metabolic-activity-of-mouse-and-human-aldehyde-oxidases-and-influence-on-drug-drug-interactions
#15
Naoki Takaoka, Seigo Sanoh, Katsuhiro Okuda, Yaichiro Kotake, Go Sugahara, Ami Yanagi, Yuji Ishida, Chise Tateno, Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura, Mami Kurosaki, Mineko Terao, Enrico Garattini, Shigeru Ohta
As aldehyde oxidase (AOX) plays an emerging role in drug metabolism, understanding its significance for drug-drug interactions (DDI) is important. Therefore, we tested 10 compounds for species-specific and substrate-dependent differences in the inhibitory effect of AOX activity using genetically engineered HEK293 cells over-expressing human AOX1, mouse AOX1 or mouse AOX3. The IC50 values of 10 potential inhibitors of the three AOX enzymes were determined using phthalazine and O6 -benzylguanine as substrates...
April 17, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29671381/minimal-clinically-important-differences-in-treadmill-6-minute-walk-and-patient-based-outcomes-following-supervised-and-home-based-exercise-in-peripheral-artery-disease
#16
Andrew W Gardner, Polly S Montgomery, Ming Wang
We estimated minimal clinically important differences (MCIDs) for small, moderate, and large changes in measures obtained from a standardized treadmill test, a 6-minute walk test, and patient-based outcomes following supervised and home-based exercise programs in symptomatic patients with peripheral artery disease (PAD). Patients were randomized to either 12 weeks of a supervised exercise program ( n=60), a home-based exercise program ( n=60), or an attention-control group ( n=60). Using the distribution-based method to determine MCIDs, the MCIDs for small, moderate, and large changes in peak walking time (PWT) in the supervised exercise group were 38, 95, and 152 seconds, respectively, and the changes in claudication onset time (COT) were 35, 87, and 138 seconds...
April 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29652783/minimum-clinically-important-difference-in-sf-36-scores-for-use-in-degenerative-cervical-myelopathy
#17
Jetan H Badhiwala, Christopher D Witiw, Farshad Nassiri, Muhammad A Akbar, Blessing Jaja, Jefferson R Wilson, Michael G Fehlings
STUDY DESIGN: Post-hoc analysis of 606 patients enrolled in the AOSpine CSM-NA or CSM-I prospective, multi-center cohort studies. OBJECTIVE: To determine the minimum clinically important difference (MCID) in SF-36v2 Physical Component Summary (PCS) and Mental Component Summary (MSC) scores in patients undergoing surgery for degenerative cervical myelopathy (DCM). SUMMARY OF BACKGROUND DATA: There has been a shift toward focus on patient reported outcomes (PROs) in spine surgery...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29652088/non-invasive-brain-stimulation-techniques-for-chronic-pain
#18
REVIEW
Neil E O'Connell, Louise Marston, Sally Spencer, Lorraine H DeSouza, Benedict M Wand
BACKGROUND: This is an updated version of the original Cochrane Review published in 2010, Issue 9, and last updated in 2014, Issue 4. Non-invasive brain stimulation techniques aim to induce an electrical stimulation of the brain in an attempt to reduce chronic pain by directly altering brain activity. They include repetitive transcranial magnetic stimulation (rTMS), cranial electrotherapy stimulation (CES), transcranial direct current stimulation (tDCS), transcranial random noise stimulation (tRNS) and reduced impedance non-invasive cortical electrostimulation (RINCE)...
April 13, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29624128/the-use-of-patient-reported-preoperative-activity-levels-as-a-stratification-tool-for-short-term-and-long-term-outcomes-in-patients-with-adult-spinal-deformity
#19
Micheal Raad, Brian J Neuman, Amit Jain, Hamid Hassanzadeh, Peter G Passias, Eric Klineberg, Gregory M Mundis, Themistocles S Protopsaltis, Emily K Miller, Justin S Smith, Virginie Lafage, D Kojo Hamilton, Shay Bess, Khaled M Kebaish, Daniel M Sciubba
OBJECTIVE Given the recent shift in health care toward quality reporting requirements and a greater emphasis on a cost-quality approach, patient stratification with respect to long-term outcomes and the use of health care resources is of increasing value. Stratification tools may be effective if they are simple and evidence based. The authors hypothesize that preoperative patient-reported activity levels might independently predict postoperative outcomes in patients with adult spinal deformity. METHODS This is a retrospective cohort...
April 6, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29618143/efficacy-and-safety-of-hylan-versus-hyaluronic-acid-in-the-treatment-of-knee-osteoarthritis
#20
Wen-Li Dai, Ze-Ming Lin, Dong-Hong Guo, Zhan-Jun Shi, Jian Wang
The purpose of this study was to use meta-analytic approach to compare the efficacy and safety of intraarticular hylan and hyaluronic acid (HA) for knee osteoarthritis (OA) treatment. We searched PubMed, Embase, and the Cochrane databases through July 2017 to identify Level I randomized controlled trials (RCTs) that evaluated clinical efficacy and safety of hylan compared with HA for knee OA. The primary outcomes were Visual Analogue Scale (VAS) for pain and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, and WOMAC function scores...
April 4, 2018: Journal of Knee Surgery
keyword
keyword
57799
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"