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EPC program

Yuan Guo, Robert Andre Ledesma, Ran Peng, Qiong Liu, Danyan Xu
Cardiac rehabilitation (CR) is a comprehensive program, which mainly focusses on exercise training, disease evaluation, cardiovascular risk factors control, medication therapy, psychosocial intervention, and patient education. Although the beneficial properties of CR have been widely evidenced, its mechanism is still not completely clarified. To date, endothelial progenitor cells (EPCs) have been explored by emerging studies, and evidence has suggested that CR, especially exercise training, significantly increases the function and levels of EPCs, which is likely to elucidate the profiting mechanism of CR...
July 29, 2016: Heart, Lung & Circulation
Min-Tser Liao, Wen-Chih Liu, Fu-Huang Lin, Ching-Feng Huang, Shao-Yuan Chen, Chuan-Chieh Liu, Shih-Hua Lin, Kuo-Cheng Lu, Chia-Chao Wu
Inflammation, endothelial dysfunction, and mineral bone disease are critical factors contributing to morbidity and mortality in hemodialysis (HD) patients. Physical exercise alleviates inflammation and increases bone density. Here, we investigated the effects of intradialytic aerobic cycling exercise on HD patients. Forty end-stage renal disease patients undergoing HD were randomly assigned to either an exercise or control group. The patients in the exercise group performed a cycling program consisting of a 5-minute warm-up, 20 minutes of cycling at the desired workload, and a 5-minute cool down during 3 HD sessions per week for 3 months...
July 2016: Medicine (Baltimore)
Annelies Janssens, Sisca Kohl, Toke Michielsen, Shana Van Langendonck, Birgitta I Hiddinga, Jan P van Meerbeeck
Early palliative care (EPC) should be introduced from the start of the treatment of patients with advanced lung cancer. Unfortunately, this is often not integrated in daily oncologic care. This letter wants to emphasize the importance of offering a holistic approach, meaning EPC to optimize quality of life (QoL). Illness understanding is important because patients with better understanding of their disease choose more often for symptom control and less for an aggressive treatment at the end of life. This illness understanding should be achieved during communication with the treating oncologist...
April 2016: Annals of Palliative Medicine
Joanne Kaldy
The Electronic Prescriptions for Controlled Substances (EPCS) program was established by the Drug Enforcement Administration to allow health facilities to use electronic transmission and other modern technology for prescribing controlled substances and replacing old technology such as fax. Its goal is to eliminate fraud, abuse, and diversion of controlled medications while streamlining the processes of making them more easily available to patients in need. While rules regarding EPCS have the potential to improve care and give practitioners more data for quality improvement, they also may create new challenges for practitioners, facilities, and vendors alike...
April 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Emeline M Van Craenenbroeck, Geert Frederix, Nele Pattyn, Paul Beckers, Amaryllis H Van Craenenbroeck, Andreas Gevaert, Nadine Possemiers, Veronique Cornelissen, Kaatje Goetschalckx, Christiaan J Vrints, Luc Vanhees, Vicky Y Hoymans
In this large multicenter trial, we aimed to assess the effect of aerobic exercise training in stable coronary artery disease (CAD) patients on cellular markers of endothelial integrity and to examine their relation with improvement of endothelial function. Two-hundred CAD patients (left ventricular ejection fraction > 40%, 90% male, mean age 58.4 ± 9.1 yr) were randomized on a 1:1 base to a supervised 12-wk rehabilitation program of either aerobic interval training or aerobic continuous training on a bicycle...
December 1, 2015: American Journal of Physiology. Heart and Circulatory Physiology
R Castejon, C Jimenez-Ortiz, S Rosado, P Tutor-Ureta, S Mellor-Pita, M Yebra-Bango
OBJECTIVES: Metabolic syndrome (MetS) is highly prevalent in patients with systemic lupus erythematosus (SLE) and it has been associated with increased cardiovascular risk. We examined the contribution of MetS to inflammatory markers, arterial stiffness and circulating endothelial progenitor cells (EPCs) as surrogates of subclinical atherosclerosis. METHODS: Cardiovascular risk factors, SLE-specific factors and peripheral blood EPCs were assessed in 50 female SLE patients...
February 2016: Lupus
G Alec Rooke, Stefan A Lombaard, Gail A Van Norman, Jörg Dziersk, Krishna M Natrajan, Lyle W Larson, Jeanne E Poole
BACKGROUND: Management of cardiovascular implantable electronic devices (CIEDs), including pacemakers and implantable cardioverter defibrillators, for surgical procedures is challenging due to the increasing number of patients with CIEDs and limited availability of trained providers. At the authors' institution, a small group of anesthesiologists were trained to interrogate CIEDs, devise a management plan, and perform preoperative and postoperative programming and device testing whenever necessary...
November 2015: Anesthesiology
Sondes El Guesmi, Sonia Ben Nasr, Mehdi Afrit, Soumaya Labidi, Hamouda Boussen
BACKGROUND: Exocrine pancreatic carcinoma (EPC) occurs in the majority of cases with early locoregional spread and distant metastasis at diagnosis, leading to dismal prognosis and limited treatment options. Traditional cytotoxic chemotherapy provide only modest benefit to patients with EPC. Identification of different molecular pathways, overexpressed in pancreatic cancer cells, has provided the opportunity to develop targeted therapies with a crucial therapeutic role in this cancer setting...
February 2015: La Tunisie Médicale
Husi Letu, Masanao Hara, Gegen Tana, Yuhai Bao, Fumihiko Nishio
Nighttime lights of the human settlements (hereafter, "stable lights") are seen as a valuable proxy of social economic activity and greenhouse gas emissions at the subnational level. In this study, we propose an improved method to generate the stable lights from Defense Meteorological Satellite Program/Operational Linescan System (DMSP/OLS) daily nighttime light data for 1999. The study area includes Japan, China, India, and other 10 countries in East Asia. A noise reduction filter (NRF) was employed to generate a stable light from DMSP/OLS time-series daily nighttime light data...
September 1, 2015: Environmental Science & Technology
Aneta Żabka, Konrad Winnicki, Justyna Teresa Polit, Janusz Maszewski
DNA topoisomerase II (Topo II), a highly specialized nuclear enzyme, resolves various entanglement problems concerning DNA that arise during chromatin remodeling, transcription, S-phase replication, meiotic recombination, chromosome condensation and segregation during mitosis. The genotoxic effects of two Topo II inhibitors known as potent anti-cancer drugs, etoposide (ETO) and ellipticine (EPC), were assayed in root apical meristem cells of Allium cepa. Despite various types of molecular interactions between these drugs and DNA-Topo II complexes at the chromatin level, which have a profound negative impact on the genome integrity (production of double-strand breaks, chromosomal bridges and constrictions, lagging fragments of chromosomes and their uneven segregation to daughter cell nuclei), most of the elicited changes were apparently similar, regarding both their intensity and time characteristics...
November 2015: Plant Physiology and Biochemistry: PPB
Amaryllis H Van Craenenbroeck, Emeline M Van Craenenbroeck, Katrijn Van Ackeren, Christiaan J Vrints, Viviane M Conraads, Gert A Verpooten, Evangelia Kouidi, Marie M Couttenye
BACKGROUND: Evidence of a beneficial effect of exercise training on mediators of vascular disease is accumulating in chronic kidney disease (CKD), but its effect on vascular function in vivo still has to be established. The present study was designed to investigate whether a formal aerobic exercise training program improves peripheral endothelial function in patients with CKD stages 3 to 4. STUDY DESIGN: Randomized controlled trial with a parallel-group design. SETTING & PARTICIPANTS: 48 patients with CKD stages 3 to 4 without established cardiovascular disease were randomly assigned to either an exercise training program or usual care...
August 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Yubo Tang, Angela Jacobi, Corina Vater, Lijin Zou, Xuenong Zou, Maik Stiehler
Reduced tissue levels of endothelial progenitor cells (EPCs) and functional impairment of endothelium are frequently observed in patients with diabetes and cardiovascular disease. The vascular endothelium is specifically sensitive to oxidative stress, and this is one of the mechanisms that causes widespread endothelial dysfunction in most cardiovascular diseases and disorders. Hence attention has increasingly been paid to enhance mobilization and differentiation of EPCs for therapeutic purposes. The aim of this study was to investigate whether Icariin, a natural bioactive component known from traditional Chinese Medicine, can induce angiogenic differentiation and inhibit oxidative stress-induced cell dysfunction in bone marrow-derived EPCs (BM-EPCs), and, if so, through what mechanisms...
June 2015: Stem Cells
Nancy D Berkman, Kathleen N Lohr, Mohammed T Ansari, Ethan M Balk, Robert Kane, Marian McDonagh, Sally C Morton, Meera Viswanathan, Eric B Bass, Mary Butler, Gerald Gartlehner, Lisa Hartling, Melissa McPheeters, Laura C Morgan, James Reston, Priyanka Sista, Evelyn Whitlock, Stephanie Chang
OBJECTIVES: To revise 2010 guidance on grading the strength of evidence (SOE) of the effectiveness of drugs, devices, and other preventive and therapeutic interventions in systematic reviews produced by the Evidence-based Practice Center (EPC) program, established by the US Agency for Healthcare Research and Quality (AHRQ). STUDY DESIGN AND SETTING: A cross-EPC working group reviewed authoritative systems for grading SOE [primarily the approach from the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group] and conducted extensive discussions with GRADE and other experts...
November 2015: Journal of Clinical Epidemiology
Luc Bruyndonckx, Vicky Y Hoymans, Ann De Guchtenaere, Maria Van Helvoirt, Emeline M Van Craenenbroeck, Geert Frederix, Katrien Lemmens, Dirk K Vissers, Christiaan J Vrints, José Ramet, Viviane M Conraads
BACKGROUND AND OBJECTIVES: Endothelial dysfunction is the first, although reversible, sign of atherosclerosis and is present in obese adolescents. The primary end point of this study was to investigate the influence of a multicomponent treatment on microvascular function. Additional objectives and end points were a reduced BMI SD score, improvements in body composition, exercise capacity, and cardiovascular risk factors, an increase in endothelial progenitor cells (EPCs), and a decrease in endothelial microparticles (EMPs)...
March 2015: Pediatrics
Vladimír Teplan, Andrea Mahrová, Ivana Králová-Lesná, Jaroslav Racek, Ivo Valkovský, Milena Štollová
Levels of the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) are elevated and endothelial progenitor cells (EPCs) decreased in patients undergoing renal transplantation (Tx) and may contribute to cardiovascular complications. In this study, we tested the hypothesis that elevated ADMA and decreased EPC can be positively influenced with regular physical exercise early after Tx. Blood samples for analysis of ADMA and EPC were obtained from randomly selected 64 patients after Tx who agreed to participate in a supervised aerobic exercise program for 6 months (group I)...
March 2015: Journal of Renal Nutrition
V Teplan, I Králová Lesná, J Piťha, A Mahrová, J Racek, I Valkovský, A Sekerková, M Štollová
Level of asymmetric dimethylarginine (ADMA) is elevated and endothelial progenitor cells (EPC) and stem cells (SC) are decreased in patients undergoing renal transplantation (Tx) and may contribute to cardiovascular complications. We tested the hypothesis that ADMA, EPC and SC can be influenced with regular physical exercise early after Tx. Blood samples of ADMA, EPC, SC, adipocytokines and metabolic parameters were randomly obtained from 50 transplant patients before and 6 months after exercise program (Group I)...
2014: Physiological Research
Francesca Margheri, Laura Papucci, Nicola Schiavone, Riccardo D'Agostino, Silvana Trigari, Simona Serratì, Anna Laurenzana, Alessio Biagioni, Cristina Luciani, Anastasia Chillà, Elena Andreucci, Tommaso Del Rosso, Giancarlo Margheri, Mario Del Rosso, Gabriella Fibbi
Gangliosides and the urokinase plasminogen activator receptor (uPAR) tipically partition in specialized membrane microdomains called lipid-rafts. uPAR becomes functionally important in fostering angiogenesis in endothelial progenitor cells (EPCs) upon recruitment in caveolar-lipid rafts. Moreover, cell membrane enrichment with exogenous GM1 ganglioside is pro-angiogenic and opposite to the activity of GM3 ganglioside. On these basis, we first checked the interaction of uPAR with membrane models enriched with GM1 or GM3, relying on the adoption of solid-supported mobile bilayer lipid membranes with raft-like composition formed onto solid hydrophilic surfaces, and evaluated by surface plasmon resonance (SPR) the extent of uPAR recruitment...
January 2015: Journal of Cellular and Molecular Medicine
F D'ascenzi, V Zacà, S Maiorca, A Neri, C Aldinucci, V Sorrentino, A Causarano, M Bonifazi, S Mondillo
AIM: Hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs) are known to play a role in the vascular responses and adaptations to exercise. We performed a quantitative assessment of HSCs and EPCs in adolescents in order to investigate whether resting levels of circulating HSCs and EPCs are comparable between elite athletes and sedentary healthy subjects. METHODS: HSCs and EPCs levels were measured in adolescent competitive football players and in age- and sex-matched sedentary controls...
March 2015: Journal of Sports Medicine and Physical Fitness
Anette Hauskov Graungaard, John Sahl Andersen
Teaching communication skills is an important task in the medical curriculum. It is widely agreed that the ability to communicate with the patient is just as important as biomedical knowledge and technical skills. We present data from an early patient contact (EPC) course with integrated theoretical and practical skills inspired by modifications of Kolb's learning cycle. Our objective was to examine first-term medical students' personal experiences and challenges with EPC. A qualitative design was adopted, with data from written logbooks and focus group interviews with medical students who had recently completed an EPC course...
May 2014: Education for Primary Care
Kara Nuzback
In October 2013, the Texas Department of Public Safety officially began allowing physicians to electronically prescribe schedule II controlled substances. The practice of electronic prescription of controlled substances (EPCS) for schedule II drugs became more commonplace in March 2014, after DPS completed a small pilot program to test the accuracy of reporting schedule II drugs to the Texas Prescription Program. Sending prescription requests to a pharmacy through an electronic vendor helps reduce the risk of prescription fraud...
July 2014: Texas Medicine
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