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EPC program

Johan Denollet, Romy A van Felius, Paul Lodder, Paula M Mommersteeg, Inge Goovaerts, Nadine Possemiers, Luc Vanhees, Paul Beckers, Nele Pattyn, Emeline M Van Craenenbroeck
BACKGROUND: Type D personality (high negative affectivity and social inhibition) is associated with cardiovascular events and coronary plaque severity. Whether Type D is also related to functional vasomotion abnormalities is unknown. We examined concurrent and predictive associations of Type D with endothelial dysfunction in patients with coronary artery disease (CAD). METHODS: At baseline, 180 CAD patients (90% men; M = 58.0 years) completed Type D (DS14) and depression scales, and entered a 12-week exercise program...
February 20, 2018: International Journal of Cardiology
Tami J Stuart, Kathleen O'Neill, David Condon, Issac Sasson, Payel Sen, Yunwei Xia, Rebecca A Simmons
Maternal obesity is associated with an increased risk of obesity and metabolic disease in offspring. Increasing evidence suggests that the placenta plays an active role in fetal programming. In this study, we used a mouse model of diet-induced obesity to demonstrate that the abnormal metabolic milieu of maternal obesity sets the stage very early in pregnancy by altering the transcriptome of placenta progenitor cells in the pre-implantation (trophectoderm [TE]) and early post-implantation (ectoplacental cone [EPC]) placenta precursors which is associated with later changes in placenta development and function...
January 18, 2018: Biology of Reproduction
Zdenko Kovač
University level of Pathophysiology research and teaching in Croatia had started with the third year of Medical School of Zagreb in academic year 1919./20. Ever since, despite historical changes of the main university stake holder, the state of Croatia, Department of Pathophysiology development progressed and has made visible academic achievements, with a broader effect in medical community. The first 95 years of academic tradition and major achievements are shortly described in this paper. Professor Miroslav Mikuličić envisioned Pathophysiology in close relations with Pharmacology and made the pioneering steps of establishing the "double" department at Šalata...
December 2017: Psychiatria Danubina
Chenggui Wang, Cong Mao, Yiting Lou, Jianxiang Xu, Qingqing Wang, Zengjie Zhang, Qian Tang, Xiaolei Zhang, Huazi Xu, Yongzeng Feng
Attenuating oxidative stress-induced damage and promoting endothelial progenitor cell (EPC) differentiation are critical for ischaemic injuries. We suggested monotropein (Mtp), a bioactive constituent used in traditional Chinese medicine, can inhibit oxidative stress-induced mitochondrial dysfunction and stimulate bone marrow-derived EPC (BM-EPC) differentiation. Results showed Mtp significantly elevated migration and tube formation of BM-EPCs and prevented tert-butyl hydroperoxide (TBHP)-induced programmed cell death through apoptosis and autophagy by reducing intracellular reactive oxygen species release and restoring mitochondrial membrane potential, which may be mediated viamTOR/p70S6K/4EBP1 and AMPK phosphorylation...
March 2018: Journal of Cellular and Molecular Medicine
Lee Anne Roman, Jennifer E Raffo, Katherine Dertz, Bonita Agee, Denise Evans, Katherine Penninga, Tiffany Pierce, Belinda Cunningham, Peggy VanderMeulen
Objectives To address disparities in adverse birth outcomes, communities are challenged to improve the quality of health services and foster systems integration. The purpose of this study was to explore the perspectives of Medicaid-insured women about their experiences of perinatal care (PNC) across a continuum of clinical and community-based services. Methods Three focus groups (N = 21) were conducted and thematic analysis methods were used to identify basic and global themes about experiences of care...
December 2017: Maternal and Child Health Journal
Junhao Huang, Shen Wang, Fengpeng Xu, Dan Wang, Honggang Yin, Qinhao Lai, Jingwen Liao, Xiaohui Hou, Min Hu
OBJECTIVE: Circulating endothelial progenitor cells (EPCs) correlate negatively with obesity. Previous studies have shown that exercise significantly restores circulating EPC levels in obese people; however, the underlying mechanisms have not been elucidated. Recently, irisin has been reported to have a critical role in the regulation of EPCs. This exercise-induced myokine has been demonstrated to play a therapeutic role in obesity. In this study, we hypothesized that the increase in circulating irisin may form a link with increasing EPC levels in obese people after exercise...
2017: PeerJ
V Oliveira, L V de Souza, T Fernandes, S D S Junior, M H C de Carvalho, E H Akamine, L C Michelini, E M de Oliveira, M D C Franco
Intrauterine growth restriction (IUGR) can induce deleterious changes in the modulatory ability of the vascular endothelium, contributing to an increased risk of developing cardiovascular diseases in the long term. However, the mechanisms involved are not fully understood. Emerging evidence has suggested the potential role of endothelial progenitor cells (EPCs) in vascular health and repair. Therefore, we aimed to evaluate the effects of IUGR on vascular reactivity and EPCs derived from the peripheral blood (PB) and bone marrow (BM) in vitro...
July 10, 2017: Journal of Developmental Origins of Health and Disease
Keigo Kono, Ruka Hayata, Satoru Murakami, Mai Yamamoto, Maiko Kuroki, Kana Nanato, Kazuto Takahashi, Keiko Miwa, Yutaka Tsutsumi, Kazunori Okada, Sanae Kaga, Taisei Mikami, Nobuo Masauzi
BACKGROUND: Morphological characteristics of blood cells are still qualitatively defined. So a texture analysis (Tx) method using gray level co-occurrence matrices (GLCMs; CM-Tx method) was applied to images of erythrocyte precursor cells (EPCs) for quantitatively distinguishing four types of EPC stages: proerythroblast, basophilic erythroblast, polychromatic erythroblast, and orthochromatic erythroblast. METHODS: Fifty-five images of four types of EPCs were downloaded from an atlas uploaded by the Blood Cell Morphology Standardization Subcommittee (BCMSS) of the Japanese Society of Laboratory Hematology (JSLH)...
January 2018: Journal of Clinical Laboratory Analysis
Zhen Hu, Hong Wang, Guanwei Fan, Han Zhang, Xiaoying Wang, Jingyuan Mao, Yingqiang Zhao, Yi An, Yuhong Huang, Chuan Li, Lianying Chang, Xianming Chu, Li Li, Yanfen Li, Yuan Zhang, Gangjian Qin, Xiumei Gao, Boli Zhang
BACKGROUND: Endothelial progenitor cells (EPCs) derived from bone marrow are associated with the repair of vascular injury by accelerating re-endothelisation, and represent a potential therapeutic target for ischaemic disease. Danhong injection (DHI), a Chinese Materia Medica standardised product extracted from Radix Salvia miltiorrhiza and Flos Carthamus tinctorius L, is effective in the treatment of ischaemic heart disease. We assessed the effect of DHI on the mobilisation of EPCs and vascular repair mediated by EPCs after percutaneous coronary intervention (PCI)...
October 2016: Lancet
Jason Gong, Christine L Baker, Kelly H Zou, Marianna Bruno, Zhanna Jumadilova, David Lawrence, Beth Wilson, Cynthia Ewel
BACKGROUND: Smoking is the leading preventable cause of death, and tobacco control professionals continue to make progress in cessation efforts. Pharmacists can assist smokers seeking to quit by offering counseling on smoking cessation pharmacotherapies. Pragmatic randomized trials are useful for investigating practical questions about an intervention's risks, benefits, and costs in routine clinical practice. OBJECTIVE: To evaluate an enhanced pharmacy care (EPC) program involving personalized pharmacist-provided telephone counseling for supporting prescription smoking cessation medications compared with usual care (UC)...
December 2016: Journal of Managed Care & Specialty Pharmacy
Yuan Guo, Robert Andre Ledesma, Ran Peng, Qiong Liu, Danyan Xu
Cardiac rehabilitation (CR) is a comprehensive program, which mainly focusses on exercise training, disease evaluation, cardiovascular risk factors control, medication therapy, psychosocial intervention, and patient education. Although the beneficial properties of CR have been widely evidenced, its mechanism is still not completely clarified. To date, endothelial progenitor cells (EPCs) have been explored by emerging studies, and evidence has suggested that CR, especially exercise training, significantly increases the function and levels of EPCs, which is likely to elucidate the profiting mechanism of CR...
January 2017: Heart, Lung & Circulation
Min-Tser Liao, Wen-Chih Liu, Fu-Huang Lin, Ching-Feng Huang, Shao-Yuan Chen, Chuan-Chieh Liu, Shih-Hua Lin, Kuo-Cheng Lu, Chia-Chao Wu
Inflammation, endothelial dysfunction, and mineral bone disease are critical factors contributing to morbidity and mortality in hemodialysis (HD) patients. Physical exercise alleviates inflammation and increases bone density. Here, we investigated the effects of intradialytic aerobic cycling exercise on HD patients. Forty end-stage renal disease patients undergoing HD were randomly assigned to either an exercise or control group. The patients in the exercise group performed a cycling program consisting of a 5-minute warm-up, 20 minutes of cycling at the desired workload, and a 5-minute cool down during 3 HD sessions per week for 3 months...
July 2016: Medicine (Baltimore)
Annelies Janssens, Sisca Kohl, Toke Michielsen, Shana Van Langendonck, Birgitta I Hiddinga, Jan P van Meerbeeck
Early palliative care (EPC) should be introduced from the start of the treatment of patients with advanced lung cancer. Unfortunately, this is often not integrated in daily oncologic care. This letter wants to emphasize the importance of offering a holistic approach, meaning EPC to optimize quality of life (QoL). Illness understanding is important because patients with better understanding of their disease choose more often for symptom control and less for an aggressive treatment at the end of life. This illness understanding should be achieved during communication with the treating oncologist...
April 2016: Annals of Palliative Medicine
Joanne Kaldy
The Electronic Prescriptions for Controlled Substances (EPCS) program was established by the Drug Enforcement Administration to allow health facilities to use electronic transmission and other modern technology for prescribing controlled substances and replacing old technology such as fax. Its goal is to eliminate fraud, abuse, and diversion of controlled medications while streamlining the processes of making them more easily available to patients in need. While rules regarding EPCS have the potential to improve care and give practitioners more data for quality improvement, they also may create new challenges for practitioners, facilities, and vendors alike...
April 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Emeline M Van Craenenbroeck, Geert Frederix, Nele Pattyn, Paul Beckers, Amaryllis H Van Craenenbroeck, Andreas Gevaert, Nadine Possemiers, Veronique Cornelissen, Kaatje Goetschalckx, Christiaan J Vrints, Luc Vanhees, Vicky Y Hoymans
In this large multicenter trial, we aimed to assess the effect of aerobic exercise training in stable coronary artery disease (CAD) patients on cellular markers of endothelial integrity and to examine their relation with improvement of endothelial function. Two-hundred CAD patients (left ventricular ejection fraction > 40%, 90% male, mean age 58.4 ± 9.1 yr) were randomized on a 1:1 base to a supervised 12-wk rehabilitation program of either aerobic interval training or aerobic continuous training on a bicycle...
December 1, 2015: American Journal of Physiology. Heart and Circulatory Physiology
R Castejon, C Jimenez-Ortiz, S Rosado, P Tutor-Ureta, S Mellor-Pita, M Yebra-Bango
OBJECTIVES: Metabolic syndrome (MetS) is highly prevalent in patients with systemic lupus erythematosus (SLE) and it has been associated with increased cardiovascular risk. We examined the contribution of MetS to inflammatory markers, arterial stiffness and circulating endothelial progenitor cells (EPCs) as surrogates of subclinical atherosclerosis. METHODS: Cardiovascular risk factors, SLE-specific factors and peripheral blood EPCs were assessed in 50 female SLE patients...
February 2016: Lupus
G Alec Rooke, Stefan A Lombaard, Gail A Van Norman, Jörg Dziersk, Krishna M Natrajan, Lyle W Larson, Jeanne E Poole
BACKGROUND: Management of cardiovascular implantable electronic devices (CIEDs), including pacemakers and implantable cardioverter defibrillators, for surgical procedures is challenging due to the increasing number of patients with CIEDs and limited availability of trained providers. At the authors' institution, a small group of anesthesiologists were trained to interrogate CIEDs, devise a management plan, and perform preoperative and postoperative programming and device testing whenever necessary...
November 2015: Anesthesiology
Sondes El Guesmi, Sonia Ben Nasr, Mehdi Afrit, Soumaya Labidi, Hamouda Boussen
BACKGROUND: Exocrine pancreatic carcinoma (EPC) occurs in the majority of cases with early locoregional spread and distant metastasis at diagnosis, leading to dismal prognosis and limited treatment options. Traditional cytotoxic chemotherapy provide only modest benefit to patients with EPC. Identification of different molecular pathways, overexpressed in pancreatic cancer cells, has provided the opportunity to develop targeted therapies with a crucial therapeutic role in this cancer setting...
February 2015: La Tunisie Médicale
Husi Letu, Masanao Hara, Gegen Tana, Yuhai Bao, Fumihiko Nishio
Nighttime lights of the human settlements (hereafter, "stable lights") are seen as a valuable proxy of social economic activity and greenhouse gas emissions at the subnational level. In this study, we propose an improved method to generate the stable lights from Defense Meteorological Satellite Program/Operational Linescan System (DMSP/OLS) daily nighttime light data for 1999. The study area includes Japan, China, India, and other 10 countries in East Asia. A noise reduction filter (NRF) was employed to generate a stable light from DMSP/OLS time-series daily nighttime light data...
September 1, 2015: Environmental Science & Technology
Aneta Żabka, Konrad Winnicki, Justyna Teresa Polit, Janusz Maszewski
DNA topoisomerase II (Topo II), a highly specialized nuclear enzyme, resolves various entanglement problems concerning DNA that arise during chromatin remodeling, transcription, S-phase replication, meiotic recombination, chromosome condensation and segregation during mitosis. The genotoxic effects of two Topo II inhibitors known as potent anti-cancer drugs, etoposide (ETO) and ellipticine (EPC), were assayed in root apical meristem cells of Allium cepa. Despite various types of molecular interactions between these drugs and DNA-Topo II complexes at the chromatin level, which have a profound negative impact on the genome integrity (production of double-strand breaks, chromosomal bridges and constrictions, lagging fragments of chromosomes and their uneven segregation to daughter cell nuclei), most of the elicited changes were apparently similar, regarding both their intensity and time characteristics...
November 2015: Plant Physiology and Biochemistry: PPB
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