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https://www.readbyqxmd.com/read/29203070/a-sirolimus-eluting-bioabsorbable-polymer-coated-stent-mistent-versus-an-everolimus-eluting-durable-polymer-stent-xience-after-percutaneous-coronary-intervention-dessolve-iii-a-randomised-single-blind-multicentre-non-inferiority-phase-3-trial
#1
Robbert J de Winter, Yuki Katagiri, Taku Asano, Krzysztof P Milewski, Philipp Lurz, Pawel Buszman, Gillian A J Jessurun, Karel T Koch, Roland P T Troquay, Bas J B Hamer, Ton Oude Ophuis, Jochen Wöhrle, Rafał Wyderka, Guillaume Cayla, Sjoerd H Hofma, Sébastien Levesque, Aleksander Żurakowski, Dieter Fischer, Maciej Kośmider, Pascal Goube, E Karin Arkenbout, Michel Noutsias, Markus W Ferrari, Yoshinobu Onuma, William Wijns, Patrick W Serruys
BACKGROUND: MiStent is a drug-eluting stent with a fully absorbable polymer coating containing and embedding a microcrystalline form of sirolimus into the vessel wall. It was developed to overcome the limitation of current durable polymer drug-eluting stents eluting amorphous sirolimus. The clinical effect of MiStent sirolimus-eluting stent compared with a durable polymer drug-eluting stents has not been investigated in a large randomised trial in an all-comer population. METHODS: We did a randomised, single-blind, multicentre, phase 3 study (DESSOLVE III) at 20 hospitals in Germany, France, Netherlands, and Poland...
December 1, 2017: Lancet
https://www.readbyqxmd.com/read/29052971/diabetes-news
#2
Ann M Carracher, Payal H Marathe, Kelly L Close
More than 15,000 attendees from more than130 countries gathered in Lisbon, Portugal for the 2017 European Association for the Study of Diabetes annual meeting. Dr Adrian Hernandez (Duke University, Durham, NC, USA) presented outcomes data from AstraZeneca's (Cambridge, UK) cardiovascular outcomes trial of GLP-1 agonist Bydureon (exenatide once weekly), Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL).(1).
October 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29017897/patients-conceptions-of-terms-related-to-sexual-interest-desire-and-arousal
#4
John D DeLamater, Kevin P Weinfurt, Kathryn E Flynn
BACKGROUND: Measurement of sexual function typically uses self-report, which, to work as intended, must use language that is understood consistently by diverse respondents. Commonly used measures employ multiple terms, primarily (sexual) interest, desire, and arousal, that might not be understood in the same way by laypeople and professionals. AIM: To inform self-reported measurement efforts for research and clinical settings by examining how US men and women recruited from a health care setting understand and interpret different terms...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28969723/who-is-behind-the-stocking-of-energy-dense-foods-and-beverages-in-small-stores-the-importance-of-food-and-beverage-distributors
#5
Guadalupe X Ayala, Heather D'Angelo, Joel Gittelsohn, Lucy Horton, Kurt Ribisl, Lesley Schmidt Sindberg, Christina Olson, Anna Kharmats, Melissa N Laska
OBJECTIVE: The present study examined food and beverage distributors' sourcing, placement and promotion of obesogenic (energy-dense, nutrient-poor) product categories from the perspective of small food store owners/managers. The obesogenic product categories of interest were savoury snacks, sugary beverages, sweet snacks, confectionery and frozen treats. Specifically, we examined how frequently distributors sourced these products, and the types of agreements and expectations they had for their placement and promotion...
October 3, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28964205/improved-scatter-correction-with-factor-analysis-for-planar-and-spect-imaging
#6
Peter Knoll, Arman Rahmim, Selma Gültekin, Martin Šámal, Michael Ljungberg, Siroos Mirzaei, Paul Segars, Boguslaw Szczupak
Quantitative nuclear medicine imaging is an increasingly important frontier. In order to achieve quantitative imaging, various interactions of photons with matter have to be modeled and compensated. Although correction for photon attenuation has been addressed by including x-ray CT scans (accurate), correction for Compton scatter remains an open issue. The inclusion of scattered photons within the energy window used for planar or SPECT data acquisition decreases the contrast of the image. While a number of methods for scatter correction have been proposed in the past, in this work, we propose and assess a novel, user-independent framework applying factor analysis (FA)...
September 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28935132/acute-leukemia-patients-needs-qualitative-findings-and-opportunities-for-early-palliative-care
#7
Nathan A Boucher, Kimberly S Johnson, Thomas W LeBlanc
BACKGROUND AND OBJECTIVE: Patients with acute leukemias likely have needs that palliative care can respond to, yet little is known about specific challenges they face, particularly during active treatment. We examined acute myeloid leukemia (AML) patients' expressed challenges and supports following intensive induction chemotherapy. We aimed to understand opportunities for palliative care interventions in this population. METHODS: A qualitative study of AML patients with high-risk disease at Duke University Hospital, Durham, NC...
September 18, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28916333/human-plasma-metabolomics-study-across-all-stages-of-age-related-macular-degeneration-identifies-potential-lipid%C3%A2-biomarkers
#8
Inês Laíns, Rachel S Kelly, John B Miller, Rufino Silva, Demetrios G Vavvas, Ivana K Kim, Joaquim N Murta, Jessica Lasky-Su, Joan W Miller, Deeba Husain
PURPOSE: To characterize the plasma metabolomic profile of patients with age-related macular degeneration (AMD) using mass spectrometry (MS). DESIGN: Cross-sectional observational study. PARTICIPANTS: We prospectively recruited participants with a diagnosis of AMD and a control group (>50 years of age) without any vitreoretinal disease. METHODS: All participants underwent color fundus photography, used for AMD diagnosis and staging, according to the Age-Related Eye Disease Study classification scheme...
August 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28840457/va-s-national-ptsd-brain-bank-a-national-resource-for-research
#9
REVIEW
Matthew J Friedman, Bertrand R Huber, Christopher B Brady, Robert J Ursano, David M Benedek, Neil W Kowall, Ann C McKee
The National PTSD Brain Bank (NPBB) is a brain tissue biorepository established to support research on the causes, progression, and treatment of PTSD. It is a six-part consortium led by VA's National Center for PTSD with participating sites at VA medical centers in Boston, MA; Durham, NC; Miami, FL; West Haven, CT; and White River Junction, VT along with the Uniformed Services University of Health Sciences. It is also well integrated with VA's Boston-based brain banks that focus on Alzheimer's disease, ALS, chronic traumatic encephalopathy, and other neurological disorders...
August 25, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28828943/from-a-global-crisis-to-the-end-of-aids-new-epidemics-of-signification
#10
Nora Kenworthy, Matthew Thomann, Richard Parker
In the past decade, discourses about AIDS have taken a remarkable, and largely unquestioned, turn. Whereas mobilisations for treatment scale-up during the 2000s were premised on perceptions of an 'epidemic out of control', we have repeatedly been informed in more recent years that an end to AIDS is immanent. This new discourse and its resulting policies are motivated by post-recession financial pressures, a changing field of global institutions, and shifting health and development priorities. These shifts also reflect a biomedical triumphalism in HIV prevention and treatment, whereby shorter term, privatised, technological, and 'cost-effective' interventions are promoted over long-term support for antiretroviral treatment...
August 22, 2017: Global Public Health
https://www.readbyqxmd.com/read/28742444/queering-biology-gutting-feminism-a-review-essay-of-gut-feminism-by-elizabeth-a-wilson-durham-nc-duke-university-press-2015
#11
David A Rubin
The author reviews Elizabeth A. Wilson's Gut Feminism (2015), arguing that Wilson's book productively challenges some of feminist theory's most entrenched presuppositions: that social, cultural, and discursive frameworks are opposed and superior to biological ones; that biological matter is flat, sovereign, monolithic, and determining; that depression is more a cultural, historical, and psychological phenomenon than a biochemical and pharmaceutical one (and that these nominative distinctions are stable and natural); and finally, that the belly's ruminations (hunger, ingestion, digestion, peristalsis, diarrhea, constipation, and excretion) give no clue as to the complexities of entanglements between gut, psyche, subjectivity, sociality, and hostility...
July 25, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28658756/unusual-severe-extra-intestinal-manifestations-of-a-common-enteric-pathogen-aeromonas-spp
#12
Barnini Banerjee, Mridula Madiyal, Lingadakai Ramchandra, Chiranjay Mukhopadhyay, Rahul Garg, Kiran Chawla
INTRODUCTION: Aeromonas spp. are halophilic, Gram-negative bacilli. They are widely distributed in the soil and aquatic environment and have been associated with various extra-intestinal infections, such as skin and soft-tissue infections, meningitis, bacteraemia etc. The most common species associated with extra-intestinal infection is Aeromonas hydrophila. AIM: To get the overview of clinical presentations, underlying predisposing factors associated with the extra-intestinal infections caused by Aeromonas species and their antimicrobial susceptibility pattern...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28611783/apolipoprotein-l1-genetic-variants-are-associated-with-chronic-kidney-disease-but-not-with-cardiovascular-disease-in-a-population-referred-for-cardiac-catheterization
#13
Hanghang Wang, Patrick H Pun, Lydia Kwee, Damian Craig, Carol Haynes, Megan Chryst-Ladd, Laura P Svetkey, Uptal D Patel, Elizabeth R Hauser, Martin R Pollak, William E Kraus, Svati H Shah
BACKGROUND: While the association between APOL1 genetic variants and chronic kidney disease (CKD) has been established, their association with cardiovascular disease (CVD) is unclear. This study sought to understand CKD and cardiovascular risk conferred by APOL1 variants in a secondary cardiovascular prevention population. METHODS: Two risk variants in APOL1 were genotyped in African-Americans (n = 1,641) enrolled in the CATHGEN biorepository, comprised of patients referred for cardiac catheterization at Duke University Hospital, Durham, NC, USA (2001-2010)...
February 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28604302/nancy-rose-hunt-a-nervous-state-violence-remedies-and-reverie-in-colonial-congo-durham-nc-duke-university-press-2016-pp-xviii-353-paperback-26-95-isbn-978-0-8223-5965-4
#14
https://www.readbyqxmd.com/read/28577677/corrigendum-to-association-of-standard-clinical-and-laboratory-variables-with-red-blood-cell-distribution-width-rdw-am-heart-j-2016-22-28
#15
Patrícia O Guimarães, Jie-Lena Sun, Kristian Kragholm, Svati H Shah, Karen S Pieper, William E Kraus, Elizabeth R Hauser, Christopher B Granger, L Kristin Newby
No abstract text is available yet for this article.
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28539343/multicenter-clinical-evaluation-of-bact-alert-virtuo-blood-culture-system
#16
Michael R Jacobs, Tony Mazzulli, Kevin C Hazen, Caryn E Good, Ayman M Abdelhamed, Pauline Lo, Bianche Shum, Katharine P Roman, Danielle C Robinson
BacT/Alert Virtuo is an advanced, automated blood culture system incorporating improved automation and an enhanced detection algorithm to shorten time to detection. A multicenter study of the investigational Virtuo system (bioMérieux, Inc., Durham, NC) compared to BacT/Alert 3D (BTA3D) for detection of bacteremia/fungemia in four bottle types, SA and FA Plus (aerobic) and SN and FN Plus (anaerobic), was performed in a clinical setting with patient samples in a matched system design clinical trial. Blood was added to paired aerobic or anaerobic bottles, with the volume in each bottle in each pair required to be ≤10 ml and with the volumes required to be within 30% of each other...
August 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28500506/a-controlled-comparison-of-the-bact-alert%C3%A2-3d-and-virtuo%C3%A2-microbial-detection-systems
#17
H Totty, M Ullery, J Spontak, J Viray, M Adamik, B Katzin, W M Dunne, P Deol
The performance of the next-generation BacT/ALERT® VIRTUO™ Microbial Detection System (VIRTUO™, bioMérieux Inc., Hazelwood, MO) was compared to the BacT/ALERT® 3D Microbial Detection System (3D, bioMérieux Inc., Durham, NC) using BacT/ALERT® FA Plus (FA Plus), BacT/ALERT® PF Plus (PF Plus), BacT/ALERT® FN Plus (FN Plus), BacT/ALERT® Standard Aerobic (SA), and BacT/ALERT® Standard Anaerobic (SN) blood culture bottles (bioMérieux Inc., Durham, NC). A seeded limit of detection (LoD) study was performed for each bottle type in both systems...
October 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28337082/pharmacokinetics-of-peramivir-in-an-adolescent-patient-receiving-continuous-venovenous-hemodiafiltration
#19
Ryan C Dillon, Robert Witcher, Jeffrey J Cies, Wayne S Moore, Arun Chopra
Critically ill patients requiring renal replacement therapy commonly experience pharmacokinetic alterations. This case report describes the pharmacokinetics of peramivir (Rapivab, BioCryst Pharmaceuticals, Inc, Durham, NC), the first US Food and Drug Administration-approved intravenous neuraminidase inhibitor for the treatment of influenza, in an adolescent patient receiving continuous renal replacement therapy (CRRT). A 49.5-kg, 17-year-old Caucasian female presented with fever, cough, and persistent hypoxia...
January 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28202601/cell-scientist-to-watch-arun-shukla
#20
(no author information available yet)
Arun Shukla received his master's degree in Biotechnology from the Jawaharlal Nehru University in New Delhi, and joined the lab of Nobel laureate Hartmut Michel at the Max Planck Institute of Biophysics in Frankfurt, Germany, for his PhD. He then moved to the United States for his postdoctoral work with Robert Lefkowitz at Duke University (Durham, NC) in a very close collaboration with Brian Kobilka (Stanford University, CA). Arun became an Assistant Professor in the Department of Medicine at Duke University in 2011, before returning to India in April 2014 as an Assistant Professor at the Indian Institute of Technology (IIT) in Kanpur as a Wellcome Trust DBT India Alliance Intermediate Fellow...
February 15, 2017: Journal of Cell Science
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