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https://www.readbyqxmd.com/read/28658756/unusual-severe-extra-intestinal-manifestations-of-a-common-enteric-pathogen-aeromonas-spp
#1
Barnini Banerjee, Mridula Madiyal, Lingadakai Ramchandra, Chiranjay Mukhopadhyay, Rahul Garg, Kiran Chawla
INTRODUCTION: Aeromonas spp. are halophilic, Gram-negative bacilli. They are widely distributed in the soil and aquatic environment and have been associated with various extra-intestinal infections, such as skin and soft-tissue infections, meningitis, bacteraemia etc. The most common species associated with extra-intestinal infection is Aeromonas hydrophila. AIM: To get the overview of clinical presentations, underlying predisposing factors associated with the extra-intestinal infections caused by Aeromonas species and their antimicrobial susceptibility pattern...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28611783/apolipoprotein-l1-genetic-variants-are-associated-with-chronic-kidney-disease-but-not-with-cardiovascular-disease-in-a-population-referred-for-cardiac-catheterization
#2
Hanghang Wang, Patrick H Pun, Lydia Kwee, Damian Craig, Carol Haynes, Megan Chryst-Ladd, Laura P Svetkey, Uptal D Patel, Elizabeth R Hauser, Martin R Pollak, William E Kraus, Svati H Shah
BACKGROUND: While the association between APOL1 genetic variants and chronic kidney disease (CKD) has been established, their association with cardiovascular disease (CVD) is unclear. This study sought to understand CKD and cardiovascular risk conferred by APOL1 variants in a secondary cardiovascular prevention population. METHODS: Two risk variants in APOL1 were genotyped in African-Americans (n = 1,641) enrolled in the CATHGEN biorepository, comprised of patients referred for cardiac catheterization at Duke University Hospital, Durham, NC, USA (2001-2010)...
February 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28604302/nancy-rose-hunt-a-nervous-state-violence-remedies-and-reverie-in-colonial-congo-durham-nc-duke-university-press-2016-pp-xviii-353-paperback-26-95-isbn-978-0-8223-5965-4
#3
https://www.readbyqxmd.com/read/28577677/corrigendum-to-association-of-standard-clinical-and-laboratory-variables-with-red-blood-cell-distribution-width-rdw-am-heart-j-2016-22-28
#4
Patrícia O Guimarães, Jie-Lena Sun, Kristian Kragholm, Svati H Shah, Karen S Pieper, William E Kraus, Elizabeth R Hauser, Christopher B Granger, L Kristin Newby
No abstract text is available yet for this article.
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28539343/multicenter-clinical-evaluation-of-bact-alert-virtuo-blood-culture-system
#5
Michael R Jacobs, Tony Mazzulli, Kevin C Hazen, Caryn E Good, Ayman M Abdelhamed, Pauline Lo, Bianche Shum, Katharine P Roman, Danielle C Robinson
Background: The BacT/ALERT VIRTUO is an advanced, automated blood culture system incorporating improved automation and an enhanced detection algorithm to shorten time to detection.Methods: Multicenter study of the investigational VIRTUO system (bioMérieux, Inc., Durham, NC) compared to BacT/ALERT 3D (BTA3D) for detection of bacteremia/fungemia in four bottle types, SA and FA Plus (aerobic) and SN and FN Plus (anaerobic) in a clinical setting with patient samples, in a matched system design clinical trial. Blood was added to paired aerobic or anaerobic bottles, with volume in each bottle pair required to be ≤10 mL per bottle and within 30% of each other...
May 24, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28500506/a-controlled-comparison-of-the-bact-alert%C3%A2-3d-and-virtuo%C3%A2-microbial-detection-systems
#6
H Totty, M Ullery, J Spontak, J Viray, M Adamik, B Katzin, W M Dunne, P Deol
The performance of the next-generation BacT/ALERT® VIRTUO™ Microbial Detection System (VIRTUO™, bioMérieux Inc., Hazelwood, MO) was compared to the BacT/ALERT® 3D Microbial Detection System (3D, bioMérieux Inc., Durham, NC) using BacT/ALERT® FA Plus (FA Plus), BacT/ALERT® PF Plus (PF Plus), BacT/ALERT® FN Plus (FN Plus), BacT/ALERT® Standard Aerobic (SA), and BacT/ALERT® Standard Anaerobic (SN) blood culture bottles (bioMérieux Inc., Durham, NC). A seeded limit of detection (LoD) study was performed for each bottle type in both systems...
May 12, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28337082/pharmacokinetics-of-peramivir-in-an-adolescent-patient-receiving-continuous-venovenous-hemodiafiltration
#8
Ryan C Dillon, Robert Witcher, Jeffrey J Cies, Wayne S Moore, Arun Chopra
Critically ill patients requiring renal replacement therapy commonly experience pharmacokinetic alterations. This case report describes the pharmacokinetics of peramivir (Rapivab, BioCryst Pharmaceuticals, Inc, Durham, NC), the first US Food and Drug Administration-approved intravenous neuraminidase inhibitor for the treatment of influenza, in an adolescent patient receiving continuous renal replacement therapy (CRRT). A 49.5-kg, 17-year-old Caucasian female presented with fever, cough, and persistent hypoxia...
January 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28202601/cell-scientist-to-watch-arun-shukla
#9
(no author information available yet)
Arun Shukla received his master's degree in Biotechnology from the Jawaharlal Nehru University in New Delhi, and joined the lab of Nobel laureate Hartmut Michel at the Max Planck Institute of Biophysics in Frankfurt, Germany, for his PhD. He then moved to the United States for his postdoctoral work with Robert Lefkowitz at Duke University (Durham, NC) in a very close collaboration with Brian Kobilka (Stanford University, CA). Arun became an Assistant Professor in the Department of Medicine at Duke University in 2011, before returning to India in April 2014 as an Assistant Professor at the Indian Institute of Technology (IIT) in Kanpur as a Wellcome Trust DBT India Alliance Intermediate Fellow...
February 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28139245/a-metabolome-wide-study-of-dry-eye-disease-reveals-serum-androgens-as%C3%A2-biomarkers
#10
Jelle Vehof, Pirro G Hysi, Christopher J Hammond
PURPOSE: To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach. DESIGN: Cross-sectional association study. PARTICIPANTS: A total of 2819 subjects from the population-representative TwinsUK cohort in the United Kingdom, with a mean age of 57 years (range, 17-82 years). METHODS: We tested associations between 222 known serum metabolites and DED. All subjects underwent nontargeted metabolomic analysis of plasma samples using gas and liquid chromatography in combination with mass spectrometry (Metabolon Inc...
April 2017: Ophthalmology
https://www.readbyqxmd.com/read/28070733/glp-1-ra-treatment-patterns-among-type-2-diabetes-patients-in-five-european-countries
#11
Victoria Divino, Mitch DeKoven, Farhad Ali Khan, Kristina S Boye, Hélène Sapin, Kirsi Norrbacka
INTRODUCTION: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a relatively new class of injectable drugs used in the treatment of type 2 diabetes (T2D). This retrospective database study evaluated real-world treatment patterns of T2D patients initiating GLP-1 RAs in Belgium (BE), France (FR), Germany (DE), The Netherlands (NL) and Sweden (SE). METHODS: Adult T2D patients initiating exenatide twice daily (exBID), exenatide once weekly (exQW), liraglutide (LIRA) or lixisenatide (LIXI) during 2013 were identified using the QuintilesIMS (QuintilesIMS, Durham, NC, and Danbury, CT, USA) longitudinal retail pharmacy databases (LRx; BE/FR/DE/NL) and national health register data (SE)...
February 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27998337/vincanne-adams%C3%A2-ed-metrics-what-counts-in-global-health-durham-nc-duke-university-press-2016-pp-258-24-95-paperback-isbn-978-0-8223-6097-1
#12
https://www.readbyqxmd.com/read/27989489/testosterone-pellet-implantation-practices-a-sexual-medicine-society-of-north-america-smsna-member-questionnaire
#13
Michael J Piecuch, Brijesh G Patel, Lawrence Hakim, Run Wang, Hossein Sadeghi-Nejad
INTRODUCTION: There has been renewed interest in the use of subcutaneous testosterone pellets for the treatment of hypogonadism since the introduction of Testopel in 2008 by Slate Pharmaceuticals (Durham, NC, USA). Manufacturer guidelines recommend using two to six pellets; however, in the clinical setting, this is deemed insufficient. This has produced a wide variety of testosterone pellet usage that is not fully understood. AIM: To better understand subcutaneous testosterone pellet implantation practices among members of the Sexual Medicine Society of North America (SMSNA)...
January 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27930331/concentrator-photovoltaic-module-architectures-with-capabilities-for-capture-and-conversion-of-full-global-solar-radiation
#14
Kyu-Tae Lee, Yuan Yao, Junwen He, Brent Fisher, Xing Sheng, Matthew Lumb, Lu Xu, Mikayla A Anderson, David Scheiman, Seungyong Han, Yongseon Kang, Abdurrahman Gumus, Rabab R Bahabry, Jung Woo Lee, Ungyu Paik, Noah D Bronstein, A Paul Alivisatos, Matthew Meitl, Scott Burroughs, Muhammad Mustafa Hussain, Jeong Chul Lee, Ralph G Nuzzo, John A Rogers
Emerging classes of concentrator photovoltaic (CPV) modules reach efficiencies that are far greater than those of even the highest performance flat-plate PV technologies, with architectures that have the potential to provide the lowest cost of energy in locations with high direct normal irradiance (DNI). A disadvantage is their inability to effectively use diffuse sunlight, thereby constraining widespread geographic deployment and limiting performance even under the most favorable DNI conditions. This study introduces a module design that integrates capabilities in flat-plate PV directly with the most sophisticated CPV technologies, for capture of both direct and diffuse sunlight, thereby achieving efficiency in PV conversion of the global solar radiation...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27884139/brominated-flame-retardants-in-placental-tissues-associations-with-infant-sex-and-thyroid-hormone-endpoints
#15
Christopher Leonetti, Craig M Butt, Kate Hoffman, Stephanie C Hammel, Marie Lynn Miranda, Heather M Stapleton
BACKGROUND: Brominated flame retardants (BFRs) are endocrine disruptors that bioaccumulate in the placenta, but it remains unclear if they disrupt tissue thyroid hormone (TH) metabolism. Our primary goal was to investigate associations between placental BFRs, TH levels, Type 3 deiodinase (DIO3) activity and TH sulfotransferase (SULT) activities. METHODS: Placenta samples collected from 95 women who delivered term (>37 weeks) infants in Durham, NC, USA (enrolled 2010-2011) were analyzed for polybrominated diphenyl ethers (PBDEs), 2,4,6-tribromophenol (2,4,6-TBP), THs (T4, T3 and rT3), and DIO3 and TH SULT activities...
November 25, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27830020/evaluation-of-a-research-use-only-luminex-based-assay-for-measurement-of-procalcitonin-in-serum-samples
#16
Charles Garrigan, Jennifer Han, Pam Tolomeo, Katherine J Johnson, Stephen R Master, Ebbing Lautenbach, Irving Nachamkin
Research use only (RUO) assays do not undergo a validation process similar to test kits used for clinical purposes. Several studies have suggested that RUO assays need to be validated prior to use in any research studies. We evaluated a research use only Luminex platform based assay for measuring serum procalcitonin levels (Bio-Plex Pro(TM) Human Acute Phase Multiplex Assay, Bio-Rad Laboratories, Hercules, CA) for comparability with an FDA cleared assay for procalcitonin (VIDAS B.R.A.H.M.S. PCT Assay, bioMérieux, Durham, NC)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27777751/evidence-based-perioperative-medicine-comes-of-age-the-perioperative-quality-initiative-poqi-the-1st-consensus-conference-of-the-perioperative-quality-initiative-poqi
#17
EDITORIAL
Timothy E Miller, Andrew D Shaw, Michael G Mythen, Tong J Gan
The 1st POQI Consensus Conference occurred in Durham, NC, on March 4-5, 2016, and was supported by the American Society of Enhanced Recovery (ASER) and Evidence-Based Perioperative Medicine (EBPOM). The conference focused on enhanced recovery for colorectal surgery and discussed four topics-perioperative analgesia, perioperative fluid management, preventing nosocomial infection, and measurement and quality in enhanced recovery pathways.
2016: Perioperative Medicine
https://www.readbyqxmd.com/read/27570156/pulmonary-valve-replacement-with-a-trifecta-valve-is-associated-with-reduced-transvalvular-gradient
#18
Brian C Gulack, Ehsan Benrashid, Robert D B Jaquiss, Andrew J Lodge
BACKGROUND: Outcomes after surgical pulmonary valve replacement (PVR) in patients with congenital cardiac disease are limited by long-term valve deterioration, which may be hastened by turbulent flow. The use of the Trifecta valve (St. Jude Medical, Little Canada, MN) at our institution (Duke University Medical Center, Durham, NC) appears to result in low postimplantation transvalvular gradients. This study was performed to compare the early transvalvular gradient associated with the Trifecta valve with that associated with two other valves commonly used for PVR...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27521662/outcomes-of-intense-pulsed-light-therapy-for-treatment-of-evaporative-dry-eye-disease
#19
MULTICENTER STUDY
Preeya K Gupta, Gargi K Vora, Cynthia Matossian, Michelle Kim, Sandra Stinnett
OBJECTIVE: To determine the clinical outcomes of intense pulsed light (IPL) therapy for the treatment of evaporative dry eye disease (DED). DESIGN: Multicentre cohort study. PARTICIPANTS: Patients with a diagnosis of meibomian gland dysfunction (MGD) and dry eye presenting to the ophthalmology clinic at either the Duke Eye Center, Durham, NC, or Matossian Eye Associates' private practice in Pennington, NJ, and Doylestown, PA. METHODS: Clinical data were reviewed from 100 patients with diagnosis of MGD and DED who underwent IPL therapy from September 2012 through December 2014 at 1 of 2 centres (Duke Eye Center or Matossian Eye Associates)...
August 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27500855/short-term-effects-of-air-temperature-on-plasma-metabolite-concentrations-in-patients-undergoing-cardiac-catheterization
#20
Regina Hampel, Susanne Breitner, William E Kraus, Elizabeth Hauser, Svati Shah, Cavin K Ward-Caviness, Robert Devlin, David Diaz-Sanchez, Lucas Neas, Wayne Cascio, Annette Peters, Alexandra Schneider
BACKGROUND: Epidemiological studies have shown associations between air temperature and cardiovascular health outcomes. Metabolic dysregulation might also play a role in the development of cardiovascular disease. OBJECTIVES: To investigate short-term temperature effects on metabolites related to cardiovascular disease. METHODS: Concentrations of 45 acylcarnitines, 15 amino acids, ketone bodies and total free fatty acids were available in 2869 participants from the CATHeterization GENetics cohort recruited at the Duke University Cardiac Catheterization Clinic (Durham, NC) between 2001 and 2007...
November 2016: Environmental Research
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