keyword
https://read.qxmd.com/read/38496074/autoimmunity-and-cancer-two-stations-on-the-same-continuum
#1
JOURNAL ARTICLE
Inês Soldin, Nídia Pereira
INTRODUCTION: Autoimmunity has been associated with different types of cancer, including hematological malignancies like lymphomas, and solid tumors. Additionally, the potential role of medication-induced immunosuppression should be considered. AIM: Our study aimed to investigate the relationship between autoimmunity and the development of cancer, as well as the impact of immunosuppressive drugs on increasing cancer risk. METHODS: The study sample was composed of patients who developed cancer after the administration of biological agents for the treatment of autoimmune disorders...
February 2024: Curēus
https://read.qxmd.com/read/38483366/five-year-longitudinal-follow-up-of-restorative-neurostimulation-shows-durability-of-effectiveness-in-patients-with-refractory-chronic-low-back-pain-associated-with-multifidus-muscle-dysfunction
#2
JOURNAL ARTICLE
Christopher Gilligan, Willem Volschenk, Marc Russo, Matthew Green, Christopher Gilmore, Vivek Mehta, Kristiaan Deckers, Kris De Smedt, Usman Latif, Dawood Sayed, Peter Georgius, Jonathan Gentile, Bruce Mitchell, Meredith Langhorst, Frank Huygen, Ganesan Baranidharan, Vikas Patel, Eugene Mironer, Edgar Ross, Alexios Carayannopoulos, Salim Hayek, Ashish Gulve, Jean-Pierre Van Buyten, Antoine Tohmeh, Jeffrey Fischgrund, Shivanand Lad, Farshad Ahadian, Timothy Deer, William Klemme, Richard Rauck, James Rathmell, Greg Maislin, Jan Pieter Heemels, Sam Eldabe
BACKGROUND: Adults with refractory, mechanical chronic low back pain associated with impaired neuromuscular control of the lumbar multifidus muscle have few treatment options that provide long-term clinical benefit. This study hypothesized that restorative neurostimulation, a rehabilitative treatment that activates the lumbar multifidus muscles to overcome underlying dysfunction, is safe and provides relevant and durable clinical benefit to patients with this specific etiology. MATERIALS AND METHODS: In this prospective five-year longitudinal follow-up of the ReActiv8-B pivotal trial, participants (N = 204) had activity-limiting, moderate-to-severe, refractory, mechanical chronic low back pain, a positive prone instability test result indicating impaired multifidus muscle control, and no indications for spine surgery...
March 11, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38255425/robotic-assisted-nissen-fundoplication-in-pediatric-patients-a-matched-cohort-study
#3
JOURNAL ARTICLE
Rianne E M Killaars, Omar Mollema, Hamit Cakir, Ruben G J Visschers, Wim G van Gemert
BACKGROUND: Nissen Fundoplication (NF) is a frequently performed procedure in children. Robotic-assisted Nissen Fundoplication (RNF), with the utilization of the Senhance® Surgical System (SSS® ) (Asensus Surgical® Inc., Durham, NC, USA) featuring 3 mm instruments, aims to improve precision and safety in pediatric surgery. This matched cohort study assesses the safety and feasibility of RNF in children using the SSS® , comparing it with Laparoscopic Nissen Fundoplication (LNF)...
January 17, 2024: Children
https://read.qxmd.com/read/38098310/the-operational-and-financial-impact-of-adding-anaerobic-screening-of-platelets
#4
JOURNAL ARTICLE
Jorge Rios, Jonathan Webb, Beth Dy, Pampee P Young
BACKGROUND AND OBJECTIVES: We evaluated the operational and safety impact of implementing anaerobic culture screening of apheresis and pooled platelets at the American Red Cross on the already established use of the aerobic culture screening of each donation performed no sooner than 24 h following collection. MATERIALS AND METHODS: Platelets were screened for bacterial contamination with the BACT/ALERT 3D® (bioMérieux, Durham, NC) microbial detection testing system...
December 14, 2023: Transfusion
https://read.qxmd.com/read/37935930/arc-of-interference-medical-anthropology-for-worlds-on-edge-edited-by-jo%C3%A3-o-biehl-and-vincanne-adams-durham-nc-duke-university-press-2023
#5
JOURNAL ARTICLE
Steven P Black
No abstract text is available yet for this article.
November 8, 2023: Journal of Medical Humanities
https://read.qxmd.com/read/37849567/a-two-year-surveillance-of-central-line-associated-bloodstream-infections-in-the-trauma-icu-of-a-tertiary-care-hospital-in-india
#6
JOURNAL ARTICLE
Safia Maqbool, Rajni Sharma
Aim The aim of the study is to identify the risk factors and mortality associated with central line-associated bloodstream infection (CLABSI) and to investigate the incidence and associated etiology in trauma patients admitted to the trauma ICU (TICU) of a tertiary care teaching hospital in Northern India. Materials and methods The study was a prospective study conducted in the trauma ICU of a tertiary care teaching hospital in India from November 2020 to October 2022. Adult patients >18 years of age who were on central line for >48 hours were included in the study...
September 2023: Curēus
https://read.qxmd.com/read/37814330/lipidome-of-mammographic-breast-density-in-premenopausal-women
#7
JOURNAL ARTICLE
Kayla R Getz, Myung Sik Jeon, Chongliang Luo, Jingqin Luo, Adetunji T Toriola
BACKGROUND: High mammographic breast density (MBD) is a strong risk factor for breast cancer development, but the biological mechanisms underlying MBD are unclear. Lipids play important roles in cell differentiation, and perturbations in lipid metabolism are implicated in cancer development. Nevertheless, no study has applied untargeted lipidomics to profile the lipidome of MBD. Through this study, our goal is to characterize the lipidome of MBD in premenopausal women. METHODS: Premenopausal women were recruited during their annual screening mammogram at the Washington University School of Medicine in St...
October 9, 2023: Breast Cancer Research: BCR
https://read.qxmd.com/read/37766228/characterization-of-diverse-anelloviruses-cressdnaviruses-and-bacteriophages-in-the-human-oral-dna-virome-from-north-carolina-usa
#8
JOURNAL ARTICLE
Elise N Paietta, Simona Kraberger, Joy M Custer, Karla L Vargas, Claudia Espy, Erin Ehmke, Anne D Yoder, Arvind Varsani
The diversity of viruses identified from the various niches of the human oral cavity-from saliva to dental plaques to the surface of the tongue-has accelerated in the age of metagenomics. This rapid expansion demonstrates that our understanding of oral viral diversity is incomplete, with only a few studies utilizing passive drool collection in conjunction with metagenomic sequencing methods. For this pilot study, we obtained 14 samples from healthy staff members working at the Duke Lemur Center (Durham, NC, USA) to determine the viral diversity that can be identified in passive drool samples from humans...
August 26, 2023: Viruses
https://read.qxmd.com/read/37463485/safety-in-senhance%C3%A2-robotic-gastrointestinal-surgery-in-530-patients
#9
JOURNAL ARTICLE
Ludger Staib, Clemens Poth, Florian Schilcher, Olaf Hansen, Vivianda Menke, Dietmar Stephan, Frank Willeke
The Senhance Robotic System™ (Asensus Surgical, Durham, NC, USA) has been used in abdominal surgery since 2016, and provides an eye-tracker for camera movement and haptic tactile feedback. Safety aspects are very important in robotic surgery, such as regarding the presence of system malfunctions and surgical outcomes. The data for robotic function in gastrointestinal surgical procedures in 530 patients (colorectal surgery, fundoplication, others) were prospectively listed in the TRUST registry after informed patient consent in three German gastrointestinal surgery centers (center A, N = 46 patients; center B, N = 457; center C, N =27)...
July 18, 2023: Surgical Technology International
https://read.qxmd.com/read/37204750/the-quantra-system-system-description-and-protocols-for-measurements
#10
JOURNAL ARTICLE
Oksana Volod, Francesco Viola
Over the past two decades, the TEG 5000 (Haemonetics Corp, Braintree, MA) and ROTEM delta (Werfen, Bedford, MA) have been the principal viscoelastic (VET) technologies. These legacy technologies are based on the "cup and pin" principle. The Quantra System (HemoSonics, LLC, Durham, NC) is a new device that assesses blood viscoelastic properties by ultrasound (SEER Sonorheometry). It is cartridge based, automated device that provides simplified specimen management and increased results reproducibility. In the present chapter, we provide a description of the Quantra and its principle of operation, currently available cartridges/assays with their respective clinical indications, device operation, and results interpretation...
2023: Methods in Molecular Biology
https://read.qxmd.com/read/37058188/envisioning-african-intersex-challenging-colonial-and-racist-legacies-in-south-african-medicine-by-amanda-lock-swarr-%C3%A2-durham-nc-duke-university-press-2023
#11
JOURNAL ARTICLE
Elizabeth Reis
No abstract text is available yet for this article.
April 14, 2023: Journal of Medical Humanities
https://read.qxmd.com/read/37004712/recombinant-polio-rhinovirus-immunotherapy-for-recurrent-paediatric-high-grade-glioma-a-phase-1b-trial
#12
JOURNAL ARTICLE
Eric M Thompson, Daniel Landi, Michael C Brown, Henry S Friedman, Roger McLendon, James E Herndon, Evan Buckley, Dani P Bolognesi, Eric Lipp, Kristin Schroeder, Oren J Becher, Allan H Friedman, Zachary McKay, Ashley Walter, Stevie Threatt, Denise Jaggers, Annick Desjardins, Matthias Gromeier, Darell D Bigner, David M Ashley
BACKGROUND: Outcomes of recurrent paediatric high-grade glioma are poor, with a median overall survival of less than 6 months. Viral immunotherapy, such as the polio-rhinovirus chimera lerapolturev, is a novel approach for treatment of recurrent paediatric high-grade glioma and has shown promise in adults with recurrent glioblastoma. The poliovirus receptor CD155 is ubiquitously expressed in malignant paediatric brain tumours and is a treatment target in paediatric high-grade glioma. We aimed to assess the safety of lerapolturev when administered as a single dose intracerebrally by convection enhanced delivery in children and young people with recurrent WHO grade 3 or grade 4 glioma, and to assess overall survival in these patients...
March 30, 2023: Lancet Child & Adolescent Health
https://read.qxmd.com/read/36999737/cryoprecipitate-contaminated-with-cupriavidus-pauculus-a-rare-cautionary-case-report
#13
Wenxin Li, Yongjun Wang, Wenjuan Han, Guomei Yin
AIMS: The aim was to define the source of contamination of cryoprecipitate intercepted during visual inspection before transfusion. MATERIALS AND METHODS: A clot was observed in one unit of cryoprecipitate before blood transfusion at the Dongyang People's Hospital. Bacterial cultures were performed using the BacT/ALERT system (BacT/ALERT 3D, bioMerieux, Durham, NC). The isolated bacteria were identified through conventional biochemical identification, matrix-assisted laser desorption ionization-time of flight mass spectrometry, and molecular analysis based on 16sr RNA...
June 2023: Transfusion
https://read.qxmd.com/read/36778074/impact-of-a-universal-perinatal-home-visiting-program-on-reduction-in-race-disparities-in-maternal-and-child-health-two-randomised-controlled-trials-and-a-field-quasi-experiment
#14
JOURNAL ARTICLE
Kenneth A Dodge, W Benjamin Goodman, Yu Bai, Debra L Best, Peter Rehder, Sherika Hill
BACKGROUND: Public health interventions must become accountable for reduction of race disparities, particularly among Black, Hispanic, and Non-Hispanic White families in the United States. Family Connects (FC) is a universal perinatal home-visiting program that assesses family-specific needs, offers support, and provides connections to community resources to address identified needs. Two previously-published randomised controlled trials and a field quasi-experiment have shown positive impact on maternal mental health, infant emergency medical care utilization, and government investigations for child maltreatment; however, these reports have not tested impact on reducing race disparities in these outcomes...
November 2022: Lancet Reg Health Am
https://read.qxmd.com/read/36724298/a-novel-polypropylene-mesh-t-line%C3%A2-for-abdominal-wall-repair-early-experience-at-three-centers-in-the-united-states
#15
JOURNAL ARTICLE
Diego L Lima, Sarah Mohamedaly, Andrew Hollins, Jin Yoo, Hobart Harris, Flavio Malcher
Mesh suture was initially developed and investigated to overcome suture pull-through in hernia repair. It has a large area compared to standard suture which distributes the load in tissue, reducing stress at the suture/tissue interface and preventing suture from cutting through tissue or the mesh. This report describes our early experience using the new T-line® mesh (Deep Blue Medical Advances, Durham, NC, USA) in patients with incisional and primary ventral hernia repairs. This is a descriptive, retrospective study in 18 patients who underwent abdominal wall repair with T-Line® mesh from November 2020 to November 2021 in three academic centers...
February 1, 2023: Surgical Technology International
https://read.qxmd.com/read/36719243/evaluation-of-piperacillin-tazobactam-testing-against-enterobacterales-by-the-phoenix-microscan-and-vitek2-tests-using-updated-clinical-and-laboratory-standards-institute-breakpoints
#16
JOURNAL ARTICLE
Carmila Manuel, Richard Maynard, April Abbott, Kara Adams, Kevin Alby, Amy Sweeney, Jennifer Dien Bard, Irvin Ibarra Flores, Violet Rekasius, Amanda Harrington, Tiffany S Kidd, Amy J Mathers, Tsigereda Tekle, Patricia J Simner, Romney M Humphries
In 2022, the Clinical and Laboratory Standards Institute (CLSI) updated piperacillin-tazobactam (TZP) breakpoints for Enterobacterales , based on substantial data suggesting that historical breakpoints did not predict treatment outcomes for TZP. The U.S. Food and Drug Administration (FDA) has not yet adopted these breakpoints, meaning commercial manufacturers of antimicrobial susceptibility testing devices cannot obtain FDA clearance for the revised breakpoints. We evaluated the Phoenix (BD, Sparks, MD), MicroScan (Beckman Coulter, Sacramento, CA), and Vitek2 (bioMérieux, Durham, NC) TZP MICs compared to reference broth microdilution for a collection of 284 Enterobacterales isolates...
February 22, 2023: Journal of Clinical Microbiology
https://read.qxmd.com/read/36660791/patient-religiosity-and-desire-for-chaplain-services-in-an-outpatient-primary-care-clinic
#17
JOURNAL ARTICLE
Katherine K Henderson, John P Oliver, Patrick Hemming
Outpatient chaplaincy is a new specialty in healthcare, with a relative paucity of research studies exploring the need for spiritual care interventions in ambulatory settings. Over the past 3 years, our interdisciplinary team at the Duke Outpatient Clinic has piloted the extension of professional spiritual care into this hospital-based resident teaching clinic offering primary care to underserved populations in Durham, NC. In this article, we report the results of a series of surveys that we conducted at the clinic to assess patients' perceptions of chaplain services, understanding of Chaplains' roles, and desire for chaplain services in specific hypothetical scenarios...
June 2023: Journal of Pastoral Care & Counseling: JPCC
https://read.qxmd.com/read/36607483/suspicion-vaccines-hesitancy-and-the-affective-politics-of-protection-in-barbados-by-nicole-charles-durham-nc-duke-university-press-2022
#18
JOURNAL ARTICLE
Bernice L Hausman
No abstract text is available yet for this article.
January 6, 2023: Journal of Medical Humanities
https://read.qxmd.com/read/36460017/overall-survival-with-first-line-atezolizumab-in-combination-with-vemurafenib-and-cobimetinib-in-braf-v600-mutation-positive-advanced-melanoma-imspire150-second-interim-analysis-of-a-multicentre-randomised-phase-3-study
#19
RANDOMIZED CONTROLLED TRIAL
Paolo A Ascierto, Daniil Stroyakovskiy, Helen Gogas, Caroline Robert, Karl Lewis, Svetlana Protsenko, Rodrigo P Pereira, Thomas Eigentler, Piotr Rutkowski, Lev Demidov, Natalia Zhukova, Jacob Schachter, Yibing Yan, Ivor Caro, Christian Hertig, Cloris Xue, Lieke Kusters, Grant A McArthur, Ralf Gutzmer
BACKGROUND: Primary analysis of the phase 3 IMspire150 study showed improved investigator-assessed progression-free survival with first-line atezolizumab, vemurafenib, and cobimetinib (atezolizumab group) versus placebo, vemurafenib, and cobimetinib (control group) in patients with BRAFV600 mutation-positive melanoma. With a median follow-up of 18·9 months (IQR 10·4-23·8) at the primary analysis, overall survival data were immature. Here, we report the results from the second, prespecified, interim overall survival analysis...
January 2023: Lancet Oncology
https://read.qxmd.com/read/36420969/first-person-tylor-lewis
#20
JOURNAL ARTICLE
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Tylor Lewis is first author on ' Microvesicle release from inner segments of healthy photoreceptors is a conserved phenomenon in mammalian species', published in DMM. Tylor is a postdoc in the lab of Vadim Arshavsky at Duke University Medical Center, Durham, NC, USA, investigating the biology of the visual system and the pathophysiological mechanisms of retinal disease...
November 1, 2022: Disease Models & Mechanisms
keyword
keyword
57788
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.