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https://www.readbyqxmd.com/read/27913041/impact-of-lymph-node-evaluation-in-adjuvant-and-neoadjuvant-chemotherapy-settings-on-survival-outcomes-in-wilms-tumour-a-review-of-185-cases-from-a-single-institution
#1
Ronica H Nanda, Bahig M Shehata, Nasim Khoshnam, Megan Durham, Sungjin Kim, Wasim Selwanes, Zhengjia Chen, Chao Zhang, Natia Esiashvili
It is unclear if lymph node sampling in Wilms tumour, though critical for staging purposes, affects survival outcomes. The value of lymph node sampling in patients treated with neoadjuvant chemotherapy (NAC) is even more uncertain. We reviewed our institutional data to determine the impact of lymph node sampling on survival, as well as its role in the context of NAC. A total of 185 patients with Wilms tumour treated at our institution were included in this analysis. The number of nodes sampled (≤7, or >7), lymph node status (unknown, negative, or positive), pathological stage, and use of neoadjuvant chemotherapy were analysed for survival outcomes...
November 29, 2016: Pathology
https://www.readbyqxmd.com/read/27910424/a-study-of-cr-39-plastic-charged-particle-detector-replacement-by-consumer-imaging-sensors
#2
K O Plaud-Ramos, M S Freeman, W Wei, E Guardincerri, J D Bacon, J Cowan, J M Durham, D Huang, J Gao, M A Hoffbauer, D J Morley, C L Morris, D C Poulson, Zhehui Wang
Consumer imaging sensors (CIS) are examined for real-time charged-particle detection and CR-39 plastic detector replacement. Removing cover glass from CIS is hard if not impossible, in particular for the latest inexpensive webcam models. We show that $10-class CIS are sensitive to MeV and higher energy protons and α-particles by using a (90)Sr β-source with its cover glass in place. Indirect, real-time, high-resolution detection is also feasible when combining CIS with a ZnS:Ag phosphor screen and optics...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909026/student-buy-in-to-active-learning-in-a-college-science-course
#3
Andrew J Cavanagh, Oriana R Aragón, Xinnian Chen, Brian Couch, Mary Durham, Aiyana Bobrownicki, David I Hanauer, Mark J Graham
The benefits of introducing active learning in college science courses are well established, yet more needs to be understood about student buy-in to active learning and how that process of buy-in might relate to student outcomes. We test the exposure-persuasion-identification-commitment (EPIC) process model of buy-in, here applied to student (n = 245) engagement in an undergraduate science course featuring active learning. Student buy-in to active learning was positively associated with engagement in self-regulated learning and students' course performance...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27896841/dental-pain-in-the-medical-emergency-department-a-cross-sectional-study
#4
C C Currie, S J Stone, J Connolly, J Durham
OBJECTIVE: To examine the number of patients attending a medical emergency department (MED) with dental problems over a three year period. DESIGN: A cross sectional study was carried out as part of a service evaluation. Data were collected via a database search of patient attendances at the MED using free text and the 10(th) revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) for oral and dental diagnoses. Data were analysed using descriptive statistics, T-Test, and chi-squared tests...
November 28, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27895895/allergy-immunotherapy-across-the-life-cycle-to-promote-active-and-healthy-ageing-from-research-to-policies-an-airways-integrated-care-pathways-icps-programme-item-action-plan-b3-of-the-european-innovation-partnership-on-active-and-healthy-ageing-and-the-global
#5
REVIEW
M A Calderon, P Demoly, T Casale, C A Akdis, C Bachert, M Bewick, B M Bilò, B Bohle, S Bonini, A Bush, D P Caimmi, G W Canonica, V Cardona, A M Chiriac, L Cox, A Custovic, F De Blay, P Devillier, A Didier, G Di Lorenzo, G Du Toit, S R Durham, P Eng, A Fiocchi, A T Fox, R Gerth van Wijk, R M Gomez, T Haathela, S Halken, P W Hellings, L Jacobsen, J Just, L K Tanno, J Kleine-Tebbe, L Klimek, E F Knol, P Kuna, D E Larenas-Linnemann, A Linneberg, M Matricardi, H J Malling, R Moesges, J Mullol, A Muraro, N Papadopoulos, G Passalacqua, E Pastorello, O Pfaar, D Price, P Rodriguez Del Rio, R Ruëff, B Samolinski, G K Scadding, G Senti, M H Shamji, A Sheikh, J C Sisul, D Sole, G J Sturm, A Tabar, R Van Ree, M T Ventura, C Vidal, E M Varga, M Worm, T Zuberbier, J Bousquet
Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27894732/tele-assessment-of-the-berg-balance-scale-effects-of-transmission-characteristics
#6
Kavita Venkataraman, Michelle Morgan, Kristopher A Amis, Lawrence R Landerman, Gerald Ch Koh, Kevin Caves, Helen Hoenig
OBJECTIVE: To compare Berg Balance Scale (BBS) rating using videos with differing transmission characteristics against direct in-person rating DESIGN: Repeated measures study for assessment of BBS in eight configurations - in person, high definition video with slow motion review, standard videos with varying bandwidths and frame rates [768 kilobytes per second (kbps) videos at 8,15 and 30 frames per second (fps), 30 fps videos at 128, 384 and 768 kbps] SETTING: Durham VA Medical Center PARTICIPANTS: 45 patients with limitations in one or more of fine motor coordination, gross motor coordination, gait and balance...
November 25, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27893334/can-segmentectomy-still-be-proposed-as-an-alternative-to-lobectomy-in-2016
#7
Berardino De Bari, André Durham, Jean Bourhis, Mahmut Ozsahin
No abstract text is available yet for this article.
November 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27884139/brominated-flame-retardants-in-placental-tissues-associations-with-infant-sex-and-thyroid-hormone-endpoints
#8
Christopher Leonetti, Craig M Butt, Kate Hoffman, Stephanie C Hammel, Marie Lynn Miranda, Heather M Stapleton
BACKGROUND: Brominated flame retardants (BFRs) are endocrine disruptors that bioaccumulate in the placenta, but it remains unclear if they disrupt tissue thyroid hormone (TH) metabolism. Our primary goal was to investigate associations between placental BFRs, TH levels, Type 3 deiodinase (DIO3) activity and TH sulfotransferase (SULT) activities. METHODS: Placenta samples collected from 95 women who delivered term (>37 weeks) infants in Durham, NC, USA (enrolled 2010-2011) were analyzed for polybrominated diphenyl ethers (PBDEs), 2,4,6-tribromophenol (2,4,6-TBP), THs (T4, T3 and rT3), and DIO3 and TH SULT activities...
November 25, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27874202/defining-pollen-exposure-times-for-clinical-trials-of-allergen-immunotherapy-for-pollen-induced-rhinoconjunctivitis-an-eaaci-position-paper
#9
O Pfaar, K Bastl, U Berger, J Buters, M A Calderon, B Clot, U Darsow, P Demoly, S R Durham, C Galán, R Gehrig, R Gerth van Wijk, L Jacobsen, L Klimek, M Sofiev, M Thibaudon, K C Bergmann
BACKGROUND: Clinical efficacy of pollen allergen immunotherapy has been broadly documented in randomized controlled trials. The underlying clinical endpoints are analysed in seasonal time periods pre-defined on the basis of the background pollen concentration. However, any validated or generally accepted definition from academia or regulatory authorities for this relevant pollen-exposure intensity or period of time (season) is currently not available. Therefore, this Task Force initiative of the European Academy of Allergy and Clinical Immunology (EAACI) aimed to propose definitions based on expert-consensus...
November 22, 2016: Allergy
https://www.readbyqxmd.com/read/27869319/the-ca-2-sensitizer-ck-2066260-increases-myofibrillar-ca-2-sensitivity-and-submaximal-force-selectively-in-fast-skeletal-muscle
#10
Darren T Hwee, Arthur J Cheng, James J Hartman, Aaron C Hinken, Ken Lee, Nickie Durham, Alan J Russell, Fady I Malik, Håkan Westerblad, Jeffrey R Jasper
Skeletal muscle dysfunction occurs in many diseases and can lead to muscle weakness and premature muscle fatigue. Here we show that the fast skeletal troponin activator, CK-2066260, counteracts muscle weakness by increasing troponin Ca(2+) affinity, thereby increasing myofibrillar Ca(2+) sensitivity. Exposure to CK-2066260 resulted in a concentration-dependent increase in the Ca(2+) sensitivity of ATPase activity in isolated myofibrils and reconstituted hybrid sarcomeres containing fast skeletal muscle troponin C...
November 21, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27867506/independent-validation-of-the-pain-management-plan-in-a-multi-disciplinary-pain-team-setting
#11
Joanna Quinlan, Richard Hughes, David Laird
CONTEXT/BACKGROUND: The Pain Management Plan (PP) is a brief cognitive behavioural therapy (CBT) self-management programme for people living with persistent pain that can be individually facilitated or provided in a group setting. Evidence of PP efficacy has been reported previously by the pain centres involved in its development. OBJECTIVES: To provide a fully independent evaluation of the PP and compare these with the findings reported by Cole et al. METHODS: The PP programme was delivered by the County Durham Pain Team (Co...
November 2016: British Journal of Pain
https://www.readbyqxmd.com/read/27856953/door-to-imaging-time-for-acute-stroke-patients-is-adversely-affected-by-emergency-department-crowding
#12
Martin A Reznek, Evangelia Murray, Marguerite N Youngren, Natassia T Durham, Sean S Michael
BACKGROUND AND PURPOSE: National guidelines call for door-to-imaging time (DIT) within 25 minutes for suspected acute stroke patients. Studies examining factors that affect DIT have focused primarily on stroke-specific care processes and patient-specific factors. We hypothesized that emergency department (ED) crowding is associated with longer DIT. METHODS: We conducted a retrospective investigation of 1 year of consecutive patients in our prospective Code Stroke registry, which included all ED stroke team activations...
November 17, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27836101/tumor-necrosis-factor-alpha-stimulates-cytokine-expression-and-transient-sensitization-of-trigeminal-nociceptive-neurons
#13
Zachary L Durham, Jordan L Hawkins, Paul L Durham
OBJECTIVE: Elevated levels of tumor necrosis factor- alpha (TNF-α) in the capsule of the temporomandibular joint (TMJ) are implicated in the underlying pathology of temporomandibular disorders (TMD). TMD are a group of conditions that result in pain in the TMJ and/or muscles of mastication, and are associated with significant social and economic burdens. The goal of this study was to investigate the effect of elevated TNF-α levels in the TMJ capsule on nocifensive behavioral response to mechanical stimulation of trigeminal neurons and regulation of cytokines within the trigeminal ganglion...
November 4, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27830020/evaluation-of-a-research-use-only-luminex-based-assay-for-measurement-of-procalcitonin-in-serum-samples
#14
Charles Garrigan, Jennifer Han, Pam Tolomeo, Katherine J Johnson, Stephen R Master, Ebbing Lautenbach, Irving Nachamkin
Research use only (RUO) assays do not undergo a validation process similar to test kits used for clinical purposes. Several studies have suggested that RUO assays need to be validated prior to use in any research studies. We evaluated a research use only Luminex platform based assay for measuring serum procalcitonin levels (Bio-Plex Pro(TM) Human Acute Phase Multiplex Assay, Bio-Rad Laboratories, Hercules, CA) for comparability with an FDA cleared assay for procalcitonin (VIDAS B.R.A.H.M.S. PCT Assay, bioMérieux, Durham, NC)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27824606/omalizumab-reduces-bronchial-mucosal-ige-and-improves-lung-function-in-non-atopic-asthma
#15
Prathap Pillai, Yih-Chih Chan, Shih-Ying Wu, Line Ohm-Laursen, Clare Thomas, Stephen R Durham, Andrew Menzies-Gow, Raj K Rajakulasingam, Sun Ying, Hannah J Gould, Chris J Corrigan
Omalizumab therapy of non-atopic asthmatics reduces bronchial mucosal IgE and inflammation and preserves/improves lung function when disease is destabilised by staged withdrawal of therapy.18 symptomatic, non-atopic asthmatics were randomised (1:1) to receive omalizumab or identical placebo treatment in addition to existing therapy for 20 weeks. Bronchial biopsies were collected before and after 12-14 weeks of treatment, then the patients destabilised by substantial, supervised reduction of their regular therapy...
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27824455/two-jet-rate-in-e-e-at-next-to-next-to-leading-logarithmic-order
#16
Andrea Banfi, Heather McAslan, Pier Francesco Monni, Giulia Zanderighi
We present the first next-to-next-to-leading-logarithmic resummation for the two-jet rate in e^{+}e^{-} annihilation in the Durham and Cambridge algorithms. The results are obtained by extending the ares method to observables involving any global, recursively infrared and collinear safe jet algorithm in e^{+}e^{-} collisions. As opposed to other methods, this approach does not require a factorization theorem for the observables. We present predictions matched to next-to-next-to-leading order and a comparison to LEP data...
October 21, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27803069/insurance-based-differences-in-time-to-diagnostic-follow-up-after-positive-screening-mammography
#17
Danielle D Durham, Whitney R Robinson, Sheila S Lee, Stephanie B Wheeler, Katherine E Reeder-Hayes, J Michael Bowling, Andrew F Olshan, Louise M Henderson
BACKGROUND: Insurance may lengthen or inhibit time to follow-up after positive screening mammography. We assessed the association between insurance status and time to initial diagnostic follow-up after a positive screening mammogram. METHODS: Using 1995-2010 data from a North Carolina population-based registry of breast imaging and cancer outcomes, we identified women with a positive screening mammogram. We compared receipt of follow-up within 60 days of screening using logistic regression and evaluated time to follow-up initiation using Cox proportional hazards regression...
November 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27803055/rebuilding-a-broken-heart-lessons-from-developmental-and-regenerative-biology
#18
REVIEW
Muge N Kuyumcu-Martinez, Michael C Bressan
In May 2016, the annual Weinstein Cardiovascular Development and Regeneration Conference was held in Durham, North Carolina, USA. The meeting assembled leading investigators, junior scientists and trainees from around the world to discuss developmental and regenerative biological approaches to understanding the etiology of congenital heart defects and the repair of diseased cardiac tissue. In this Meeting Review, we present several of the major themes that were discussed throughout the meeting and highlight the depth and range of research currently being performed to uncover the causes of human cardiac diseases and develop potential therapies...
November 1, 2016: Development
https://www.readbyqxmd.com/read/27801793/identification-of-vape-shops-in-two-north-carolina-counties-an-approach-for-states-without-retailer-licensing
#19
Joseph G L Lee, Heather D'Angelo, Jaleel D Kuteh, Ryan J Martin
Stores that sell electronic nicotine delivery systems (ENDS) as their primary product are a new phenomenon and often termed "vape shops". While vape shops are now regulated by state and federal agencies, not all states maintain lists of vape shops in operation. Standard ways of identifying tobacco retailers through off-premise alcohol permits and business listing services may not identify vape shops. We used four online business listing services (i.e., Google Maps, ReferenceUSA, YellowPages.com, Yelp) to identify vape shops in two counties in North Carolina (NC)...
October 27, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27794202/simultaneous-delivery-of-antibiotics-neomycin-and-ampicillin-in-drinking-water-inhibits-fermentation-of-resistant-starch-in-rats
#20
Diana G Carvajal-Aldaz, Justin L Guice, Ryan C Page, Anne M Raggio, Roy J Martin, Claudia Husseneder, Holiday A Durham, James Geaghan, Marlene Janes, Ted Gauthier, Diana Coulon, Michael J Keenan
SCOPE: Antibiotics ampicillin 1g/L and neomycin 0.5g/L were added to drinking water before or during feeding of resistant starch (RS) to rats to inhibit fermentation. METHODS AND RESULTS: In a preliminary study antibiotics and no RS were given prior to rats receiving a transplant of cecal contents via gavage from donor rats fed RS (without antibiotics) or a water gavage before feeding resistant starch to both groups. Antibiotics given prior to feeding RS did not prevent later fermentation of RS regardless of either type of gavage...
October 29, 2016: Molecular Nutrition & Food Research
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