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Jo Durham, Alongkone Phengsavanh, Vanphanom Sychareun, Isaac Hose, Viengnakhone Vongxay, Douangphachanh Xaysomphou, Keith Rickart
Purpose: The purpose of this study was to gather the necessary data to support the design and implementation of a pilot program for women who are unable to deliver in a healthcare facility in the Lao People's Democratic Republic (PDR), by using community distribution of misoprostol to prevent postpartum hemorrhage (PPH). The study builds on an earlier research that demonstrated both support and need for community-based distribution of misoprostol in Lao PDR. Methods: This qualitative study identified acceptability of misoprostol and healthcare system needs at varying levels to effectively distribute misoprostol to women with limited access to facility-based birthing...
2018: International Journal of Women's Health
David Gurarie, Nathan C Lo, Martial L Ndeffo-Mbah, David P Durham, Charles H King
INTRODUCTION: Schistosomiasis is a chronic parasitic trematode disease that affects over 240 million people worldwide. The Schistosoma lifecycle is complex, involving transmission via specific intermediate-host freshwater snails. Predictive mathematical models of Schistosoma transmission have often chosen to simplify or ignore the details of environmental human-snail interaction in their analyses. Schistosome transmission models now aim to provide better precision for policy planning of elimination of transmission...
May 21, 2018: PLoS Neglected Tropical Diseases
Hongyu Chen, Shihai Zhang, Inkyung Park, Sung Woo Kim
A total of 144 pigs with 18.4 ± 2.3 kg initial body weight (BW) at 6 wk of age were used in a 40-d trial to evaluate effects of protease (300,000 U/kg feed, BioResource International Inc., Durham, NC, USA) on growth performance, apparent ileal digestibility (AID) of nutrients, and gut health of pigs fed diets with sorghum. Pigs were randomly allotted to 4 treatments (12 pens per treatment, 3 pigs per pen) in a 2 × 2 factorial arrangement (corn or sorghum basal diets, and 0 or 0.05% protease as 2 factors) with sex and initial BW as blocks...
December 2017: Animal nutrition
Yousra Khalfallah, Rachel Kuta, Camille Grasmuck, Alexandre Prat, Heather D Durham, Christine Vande Velde
Stress granules (SGs) are cytoplasmic foci that form in response to various external stimuli and are essential to cell survival following stress. SGs are studied in several diseases, including ALS and FTD, which involve the degeneration of motor and cortical neurons, respectively, and are now realized to be linked pathogenically by TDP-43, originally discovered as a component of ubiquitin-positive aggregates within patients' neurons and some glial cells. So far, studies to undercover the role of TDP-43 in SGs have used primarily transformed cell lines, and thus rely on the extrapolation of the mechanisms to cell types affected in ALS/FTD, potentially masking cell specific effects...
May 15, 2018: Scientific Reports
Mercedes A Bravo, Rebecca Anthopolos, Rachel T Kimbro, Marie Lynn Miranda
Neighborhood characteristics such as racial segregation may be associated with type 2 diabetes mellitus, but studies have not examined these relationships using spatial models appropriate for geographically patterned health outcomes. We construct a local, spatial index of racial isolation (RI) for blacks, which measures the extent to which blacks are exposed to only one another, to estimate associations of diabetes with RI and examine how RI relates to spatial patterning in diabetes. We obtained 2007-2011 electronic health records from the Duke Medicine Enterprise Data Warehouse...
May 14, 2018: American Journal of Epidemiology
Daniel T Laskowitz, Ellen R Bennett, Rebecca J Durham, John J Volpi, Jonathan R Wiese, Michael Frankel, Elizabeth Shpall, Jeffry M Wilson, Jesse Troy, Joanne Kurtzberg
Stroke is a major cause of death and long-term disability, affecting one in six people worldwide. The only currently available approved pharmacological treatment for ischemic stroke is tissue plasminogen activator; however, relatively few patients are eligible for this therapy. We hypothesized that intravenous (IV) infusion of banked unrelated allogeneic umbilical cord blood (UCB) would improve functional outcomes in patients with ischemic stroke. To investigate this, we conducted a phase 1 open-label trial to assess the safety and feasibility of a single IV infusion of non-human leukocyte antigen (HLA) matched, ABO matched, unrelated allogeneic UCB into adult stroke patients...
May 12, 2018: Stem Cells Translational Medicine
A Bhagey, K Foster, S Ralph, A Wardropper, C White, V Wholey, S Duncan
BASHH guidelines recommend that 'the hepatitis A virus total antibody test can be offered to at-risk patients whose immune status is unknown … depending on local funding arrangements'. We sought to measure the local prevalence of anti-hepatitis A (HAV) IgG in HIV-negative men who have sex with men (MSM), to inform the utility of pre-vaccination screening. We assessed the prevalence of anti-HAV IgG in HIV-negative MSM who attended sexual health services in County Durham and Darlington, UK, from March to August 2017...
January 1, 2018: International Journal of STD & AIDS
Ron W Reeder, Richard J Wood, Jeffrey R Avansino, Marc A Levitt, Megan M Durham, Jonathan Sutcliffe, Paola Midrio, Casey M Calkins, Ivo de Blaauw, Belinda Hsi Dickie, Michael D Rollins
No abstract text is available yet for this article.
May 4, 2018: Techniques in Coloproctology
Corinne Saunders, Charles Fernyhough
This article draws on research from the major collaborative research project Hearing the Voice , based at Durham University, to reconsider and foreground Margery Kempe's inner voices, and hence, to return to an emphasis on inner, spiritual experience as shaping her Book . The richness of Margery's multi-sensory experience, and the care with which it is depicted, is illuminated by and illuminates the experience of contemporary voice-hearers, offering a powerful alternative perspective to often reductive bio-medical understandings...
June 2017: Postmedieval: a journal of medieval cultural studies
Oussama Abla, Eric Jacobsen, Jennifer Picarsic, Zdenka Krenova, Ronald Jaffe, Jean-Francois Emile, Benjamin H Durham, Jorge Braier, Frédéric Charlotte, Jean Donadieu, Fleur Cohen Aubart, Carlos Rodriguez-Galindo, Carl Allen, James A Whitlock, Sheila Weitzman, Kenneth L McClain, Julien Haroche, Eli L Diamond
Rosai-Dorfman-Destombes disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by accumulation of activated histiocytes within affected tissues. RDD, which now belongs to the R group of the 2016 revised histiocytoses classification, is a widely heterogeneous entity with a range of clinical phenotypes occurring in isolation or in association with autoimmune or malignant diseases. Recent studies have found NRAS, KRAS, MAP2K1 and ARAF mutations in lesional tissues, raising the possibility of a clonal origin in some forms of RDD...
May 2, 2018: Blood
Timothy G Ramsay, Margo J Stoll, Amy E Shannon, Le Ann Blomberg
Background: Recent increases in intra-litter variability in weaning weight have raised swine production costs. A contributor to this variability is the normal birth weight pig that grows at a slower rate than littermates of similar birth weight. The goal of this study was to interrogate biochemical profiles manifested in skeletal muscle originating from slow growing (SG) and faster growing littermates (control), with the aim of identifying differences in metabolic pathway utilization between skeletal muscle of the SG pig relative to its littermates...
2018: Journal of Animal Science and Biotechnology
Jason M Rizzo, Leslie A Fecher, May P Chan, Alison B Durham
No abstract text is available yet for this article.
May 2018: JAAD Case Reports
Rich Mooi, Sergio A MartÍnez, Claudia J Del RÍo, Maria inÊs feijÓ Ramos
Material for all seven South American species of late Oligocene and Miocene scutelliform, non-lunulate sand dollars (Echinoidea: Clypeasteroida) was examined, resulting in revision of several taxa, and description of a new family, Placatenellidae n. fam., to house Placatenella n. gen. and Camachoaster n. gen. Known only from the state of Pará, Brazil, and previously described as a member of Abertella Durham, 1953, A. complanata Brito, 1981 is redescribed on the basis of analysis of the holotype and subsequently described material from the same region...
January 5, 2018: Zootaxa
Adam P Goode, Shannon Stark Taylor, Susan N Hastings, Catherine Stanwyck, Cynthia J Coffman, Kelli D Allen
Background: Chronic low back pain (CLBP) is highly prevalent in older adults, leading to functional decline. Objective: The objective of this study was to evaluate physical activity (PA) only and PA plus cognitive-behavioral therapy for pain (CBT-P) among older adult veterans with CLBP. Design: This study was a pilot randomized trial comparing a 12-week telephone-supported PA-only intervention group (PA group) or PA plus CBT-P intervention group (PA + CBT-P group) and a wait-list control group (WL group)...
May 1, 2018: Physical Therapy
David A Rubin
The author reviews Elizabeth A. Wilson's Gut Feminism (2015), arguing that Wilson's book productively challenges some of feminist theory's most entrenched presuppositions: that social, cultural, and discursive frameworks are opposed and superior to biological ones; that biological matter is flat, sovereign, monolithic, and determining; that depression is more a cultural, historical, and psychological phenomenon than a biochemical and pharmaceutical one (and that these nominative distinctions are stable and natural); and finally, that the belly's ruminations (hunger, ingestion, digestion, peristalsis, diarrhea, constipation, and excretion) give no clue as to the complexities of entanglements between gut, psyche, subjectivity, sociality, and hostility...
April 3, 2018: Journal of Lesbian Studies
Mark A Stein, Jeffrey H Newcorn
Presents an obituary of C. Keith Conners (1933-2017) who passed away of heart failure in Durham, North Carolina, on July 6, 2017. Conners was a pioneer in attention-deficit/hyperactivity disorder (ADHD) research and treatment. (PsycINFO Database Record
April 2018: American Psychologist
Timothy J Durham, Maxwell W Libbrecht, J Jeffry Howbert, Jeff Bilmes, William Stafford Noble
The Encyclopedia of DNA Elements (ENCODE) and the Roadmap Epigenomics Project seek to characterize the epigenome in diverse cell types using assays that identify, for example, genomic regions with modified histones or accessible chromatin. These efforts have produced thousands of datasets but cannot possibly measure each epigenomic factor in all cell types. To address this, we present a method, PaRallel Epigenomics Data Imputation with Cloud-based Tensor Decomposition (PREDICTD), to computationally impute missing experiments...
April 11, 2018: Nature Communications
Alessandro Bellantuono, Philip A Saigh, Katherine Durham, Constance Dekis, Dusty Hackler, Leah A McGuire, Anastasia E Yasik, Phill V Halamandaris, Richard A Oberfield
OBJECTIVE: Given the need to identify psychological risk factors among traumatized youth, this study examined the family functioning of traumatized youth with or without PTSD and a nonclinical sample. METHOD: The Family Adaptability and Cohesion Evaluation Scales, second edition (FACES II; Olson, Portner, & Bell, 1982), scores of youth with posttraumatic stress disorder (PTSD; n = 29) were compared with the scores of trauma-exposed youth without PTSD (n = 48) and a nontraumatized comparison group (n = 44)...
March 2018: School Psychology Quarterly
David P Durham, Meagan C Fitzpatrick, Martial L Ndeffo-Mbah, Alyssa S Parpia, Nelson L Michael, Alison P Galvani
Background: Mosquito-borne and sexually transmitted Zika virus has become widespread across Central and South America and the Caribbean. Many Zika vaccine candidates are under active development. Objective: To quantify the effect of Zika vaccine prioritization of females aged 9 to 49 years, followed by males aged 9 to 49 years, on incidence of prenatal Zika infections. Design: A compartmental model of Zika transmission between mosquitoes and humans was developed and calibrated to empirical estimates of country-specific mosquito density...
April 3, 2018: Annals of Internal Medicine
Vanphanom Sychareun, Bangone Santavasy, Niramonh Chanlivong, Andrea Fischer, Nicholas Thomson, Robert Power, Jo Durham
BACKGROUND: Methamphetamine is one of the most widely used illicit drugs in several Southeast Asian countries, including the Lao People's Democratic Republic (PDR). The purpose of this study was to examine the socio-cultural context of its use in Lao PDR. METHODS: We conducted a cross-sectional qualitative survey among young people, aged 15-24 years, who use methamphetamine (or Yaba as it is commonly known in the region) in Vientiane Capital and Vientiane Province, Lao PDR...
April 2, 2018: Harm Reduction Journal
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