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https://www.readbyqxmd.com/read/28935132/acute-leukemia-patients-needs-qualitative-findings-and-opportunities-for-early-palliative-care
#1
Nathan A Boucher, Kimberly S Johnson, Thomas W LeBlanc
BACKGROUND AND OBJECTIVE: Patients with acute leukemias likely have needs that palliative care can respond to, yet little is known about specific challenges they face, particularly during active treatment. We examined acute myeloid leukemia (AML) patients' expressed challenges and supports following intensive induction chemotherapy. We aimed to understand opportunities for palliative care interventions in this population. METHODS: A qualitative study of AML patients with high-risk disease at Duke University Hospital, Durham, NC...
September 18, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28932383/erratum-to-allergen-immunotherapy-for-allergic-rhinoconjunctivitis-protocol-for-a-systematic-review
#2
Sangeeta Dhami, Ulugbek Nurmatov, Graham Roberts, Oliver Pfaar, Antonella Muraro, Ignacio J Ansotegui, Moises Calderon, Cemal Cingi, Pascal Demoly, Stephen Durham, Ronald Gerth van Wijk, Susanne Halken, Eckard Hamelmann, Peter Hellings, Lars Jacobsen, Edward Knol, Desiree Larenas Linnemann, Sandra Lin, Vivian Maggina, Hanneke Oude-Elberink, Giovanni Pajno, Ruby Panwankar, Elideanna Pastorello, Constantinos Pitsios, Giuseppina Rotiroti, Frans Timmermans, Olympia Tsilochristou, Eva-Maria Varga, Jamie Wilkinson, Andrew Williams, Margitta Worm, Luo Zhang, Aziz Sheikh
[This corrects the article DOI: 10.1186/s13601-016-0099-6.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28930898/it-s-all-in-the-wrist-diagnosis-and-management-of-carpal-tunnel-syndrome
#3
Catherine O Durham, Kathy VanRavenstein
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy accounting for 90% of similar disorders, occurring in 3.8% of the population, common in adults aged 40-60 years, and is associated with an average 32 lost days of work and lost productivity. In addition to occupational exposure, there are several common chronic disorders that can preclude CTS, obesity, diabetes mellitus, rheumatoid arthritis, pregnancy, metabolic syndrome, and thyroid disorder, to name a few. Therefore, it is important for the primary care provider to have knowledge in this syndrome...
September 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28923467/california-universal-health-care-bill-an-economic-stimulus-and-life-saving-proposal
#4
Alison P Galvani, David P Durham, Sten H Vermund, Meagan C Fitzpatrick
No abstract text is available yet for this article.
September 15, 2017: Lancet
https://www.readbyqxmd.com/read/28917398/hydrogel-ocular-sealant-for-clear-corneal-incisions-in-cataract-surgery
#5
Nambi Nallasamy, Karen E Grove, Gary L Legault, Melissa B Daluvoy, Terry Kim
PURPOSE: To assess the relationship between use of a hydrogel ocular sealant (Resure) to secure clear corneal incisions (CCIs) in cataract surgery and surgeon efficiency, patient symptomatology, and postoperative results. SETTING: Duke University Eye Center, Durham, North Carolina, USA. DESIGN: Retrospective case series. METHODS: A 1:1 matched cohort of hydrogel sealant exposure-discordant eyes of cataract surgery patients was retrospectively generated...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28916555/first-person-seth-zimmerman
#6
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Seth Zimmerman is the first author on 'Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration', published in Journal of Cell Science. Seth completed the work in this article as a PhD student under the supervision of Jim Bear and Brian Kuhlman at University of North Carolina at Chapel Hill, USA...
September 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28916333/human-plasma-metabolomics-study-across-all-stages-of-age-related-macular-degeneration-identifies-potential-lipid%C3%A2-biomarkers
#7
Inês Laíns, Rachel S Kelly, John B Miller, Rufino Silva, Demetrios G Vavvas, Ivana K Kim, Joaquim N Murta, Jessica Lasky-Su, Joan W Miller, Deeba Husain
PURPOSE: To characterize the plasma metabolomic profile of patients with age-related macular degeneration (AMD) using mass spectrometry (MS). DESIGN: Cross-sectional observational study. PARTICIPANTS: We prospectively recruited participants with a diagnosis of AMD and a control group (>50 years of age) without any vitreoretinal disease. METHODS: All participants underwent color fundus photography, used for AMD diagnosis and staging, according to the Age-Related Eye Disease Study classification scheme...
August 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28915062/a-recombinant-fragment-of-human-surfactant-protein-d-suppresses-basophil-activation-th2-and-b-cell-responses-in-grass-pollen-induced-allergic-inflammation
#8
Asif S Qaseem, Iesha Singh, Ansar A Pathan, Janice A Layhadi, Rebecca Parkin, Fedina Alexandra, Stephen R Durham, Uday Kishore, Mohamed H Shamji
RATIONALE: rfhSP-D has been shown to suppress house dust mite and Aspergillus fumigatus-induced allergic inflammation in murine models. OBJECTIVES: We sought to elucidate the effect of rfhSP-D on FcεRI and CD23-mediated grass pollen induced allergic inflammatory responses. METHODS: rfhSP-D, containing homotrimeric neck and lectin domains, was expressed in Escherichia coli BL21 (λDE3) pLysS. PBMCs and sera were obtained from grass pollen allergic individuals (n=27)...
September 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28912796/a-low-cost-imaging-method-for-the-temporal-and-spatial-colorimetric-detection-of-free-amines-on-maize-root-surfaces
#9
Truc H Doan, Tu A Doan, Michael J Kangas, AdreAnna E Ernest, Danny Tran, Christina L Wilson, Andrea E Holmes, Erin L Doyle, Tessa L Durham Brooks
Plant root exudates are important mediators in the interactions that occur between plants and microorganisms in the soil, yet much remains to be learned about spatial and temporal variation in their production. This work outlines a method utilizing a novel colorimetric paper to detect spatial and temporal changes in the production of nitrogen-containing compounds on the root surface. While existing methods have made it possible to conduct detailed analysis of root exudate composition, relatively less is known about where in the root system exudates are produced and how this localization changes as the root grows...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28912604/oral-health-promotion-in-the-community-pharmacy-an-evaluation-of-a-pilot-oral-health-promotion-intervention
#10
A Sturrock, H Cussons, C Jones, C Woodcock, L Bird
Introduction Poor oral health is a significant public health concern, costing the NHS in England £3.4 billion annually. Community pharmacies are easily accessible, frequently visited by patients and the community pharmacy contractual framework requires pharmacies to provide healthy living advice to patients - therefore offering a little explored avenue for the delivery of oral health interventions.Methodology A pilot oral health promotion intervention was introduced in five pharmacies in deprived areas of County Durham between September and December 2016...
September 15, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28912006/predictors-of-late-aortic-intervention-in-patients-with-medically-treated-type-b-aortic-dissection
#11
Samuel I Schwartz, Christopher Durham, W Darrin Clouse, Virendra I Patel, R Todd Lancaster, Richard P Cambria, Mark F Conrad
BACKGROUND: Patients with medically managed type B aortic dissection (TBAD) have a high incidence of aorta-related complications over time. Whereas early thoracic endovascular aortic repair (TEVAR) to seal the entry tear can promote aortic remodeling and prevent late aneurysm formation, there are sparse data as to which patients will benefit from such therapy. The goal of this study was to identify clinical and anatomic factors that are associated with the need for subsequent aortic intervention in patients who present with uncomplicated TBAD...
September 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28884402/obstructive-sleep-apnea-increases-the-risk-of-cardiopulmonary-adverse-events-associated-with-ambulatory-colonoscopy-independent-of-body-mass-index
#12
Vaishali A Patel, Paul St Romain, Juan Sanchez, Deborah A Fisher, Ryan D Schulteis
BACKGROUND: The relationship between body mass index (BMI) and cardiopulmonary adverse events (CAEs) for ambulatory colonoscopy is unclear. AIM: To assess the association of BMI and CAEs associated with ambulatory colonoscopy. METHODS: This is a retrospective cohort analysis of 418 patients who underwent outpatient colonoscopy at the Durham Veterans Affairs Medical Center categorized as normal/overweight (BMI < 30), obese (BMI 30-34), or morbidly obese (BMI ≥ 35)...
September 7, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28879244/care-pathways-in-persistent-orofacial-pain-qualitative-evidence-from-the-deep-study
#13
M Breckons, S M Bissett, C Exley, V Araujo-Soares, J Durham
Persistent orofacial pain is relatively common and known to have an adverse effect on quality of life. Previous studies suggest that the current care pathway may be problematic, but it is not well understood which health services patients access and what their experience is. The aim of this study was to explore care pathways and their impact from the perspective of patients. Qualitative interviews were conducted with a maximum variation sample of patients recruited from primary (community based) and secondary (specialist hospital based) care in the United Kingdom...
January 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28876305/sexually-transmitted-disease-testing-of-human-immunodeficiency-virus-infected-men-who-have-sex-with-men-room-for-improvement
#14
Bonnie B Dean, Mia Scott, Rachel Hart, Linda Battalora, Richard M Novak, Marcus D Durham, John T Brooks, Kate Buchacz
BACKGROUND: In the United States, sexually transmitted infection (STI) testing is recommended at least annually for sexually active men who have sex with men (MSM). We evaluated human immunodeficiency virus (HIV) providers' STI testing practices and frequency of positive test results. METHODS: We analyzed data from HIV Outpatient Study (HOPS) participants who, from 2007 to 2014, completed a confidential survey about risk behaviors. Using medical records data, we assessed the frequency of gonorrhea, chlamydia, and syphilis testing and positive results during the year after the survey for MSM who reported sex without a condom in the prior 6 months...
July 11, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28867439/mixed-methods-investigation-of-women-s-experiences-with-second-trimester-abortion-care-in-the-midwest-and-northeast-united-states
#15
Kelly Blanchard, Jill L Meadows, Hialy R Gutierrez, Curtiss Ps Hannum, Ella F Douglas-Durham, Amanda J Dennis
OBJECTIVE(S): We studied women's experiences seeking and receiving second-trimester abortion care in two geographically and legislatively different settings to inform ways to improve abortion care access and services. STUDY DESIGN: We conducted in-depth interviews with women who obtained second-trimester abortion care. Themes from the interviews were then used to inform a self-administered survey, which was completed by 108 women who received second-trimester abortion care in the Northeast and Midwest...
August 31, 2017: Contraception
https://www.readbyqxmd.com/read/28867127/utilization-of-standard-and-target-specific-oral-anticoagulants-among-adults-in-the-united-kingdom-with-incident-atrial-fibrillation
#16
Todd A Durham, Kristen Hassmiller Lich, Anthony J Viera, Jason P Fine, Jayanti Mukherjee, Morris Weinberger, Stacie B Dusetzina
New oral anticoagulants (OACs) and updated risk stratification have the potential to improve the quality of care for patients with atrial fibrillation (AF). To describe the time from AF diagnosis to the initiation of an OAC, characteristics associated with treatment, and the incidence of switching OACs, we conducted this retrospective cohort study of 23,018 adults with incident AF receiving care between 2010 and 2014 in 647 primary care practices participating in the United Kingdom Clinical Practice Research Datalink...
August 12, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28859335/a-new-mutation-in-fig4-causes-a-severe-form-of-cmt4j-involving-trpv4-in-the-pathogenic-cascade
#17
Benoit J Gentil, Erin O'Ferrall, Colin Chalk, Luis F Santana, Heather D Durham, Rami Massie
Mutations in FIG4, coding for a phosphoinositol(3,5) bisphosphate 5' phosphatase and involved in vesicular trafficking and fusion, have been shown causing a recessive form of Charcot-Marie-Tooth (CMT). We have identified a novel intronic mutation in the FIG4 in a wheel-chair bound patient presenting with a severe form of CMT4J and provide a longitudinal study. Investigations indicated a demyelinating sensorimotor polyneuropathy with diffuse active denervation and severe axonal loss. Genetic testing revealed that the patient is heterozygous for 2 FIG4 mutations, p...
September 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28854169/a-somatic-mutation-in-erythro-myeloid-progenitors-causes-neurodegenerative-disease
#18
Elvira Mass, Christian E Jacome-Galarza, Thomas Blank, Tomi Lazarov, Benjamin H Durham, Neval Ozkaya, Alessandro Pastore, Marius Schwabenland, Young Rock Chung, Marc K Rosenblum, Marco Prinz, Omar Abdel-Wahab, Frederic Geissmann
The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are characterized by progressive neuronal dysfunction and loss, and chronic glial activation. Whether microglial activation, which is generally viewed as a secondary process, is harmful or protective in neurodegeneration remains unclear. Late-onset neurodegenerative disease observed in patients with histiocytoses, which are clonal myeloid diseases associated with somatic mutations in the RAS-MEK-ERK pathway such as BRAF(V600E), suggests a possible role of somatic mutations in myeloid cells in neurodegeneration...
August 30, 2017: Nature
https://www.readbyqxmd.com/read/28851382/a-realist-synthesis-of-cross-border-patient-movement-from-low-and-middle-income-countries-to-similar-or-higher-income-countries
#19
REVIEW
Jo Durham, Sarah J Blondell
Patient travel across borders to access healthcare is becoming increasingly common and widespread. Patients moving from high income to middle income countries for healthcare is well documented, with patients seeking treatments that are cheaper or more readily available than at home. Less well understood is when patients move from one low income country to another or from a low income country to a higher income country. In this paper, a realist review was undertaken to explore why, in what contexts and how patients from lower income countries travel to countries with the same, or more advanced, economies for planned healthcare...
August 29, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28843574/the-7-factor-hybrid-model-of-dsm-5-ptsd-symptoms-and-alcohol-consumption-and-consequences-in-a-national-sample-of-trauma-exposed-veterans
#20
Meredith Claycomb Erwin, Ruby Charak, Tory A Durham, Cherie Armour, Xin Lv, Steven M Southwick, Jon D Elhai, Robert H Pietrzak
The purpose of the present study was to investigate associations between the 7-factor hybrid model of DSM-5 posttraumatic stress disorder (PTSD) symptoms, which includes intrusions, avoidance, negative affect, anhedonia, externalizing behaviors, anxious arousal, and dysphoric arousal symptoms, and alcohol consumption and consequences. A nationally representative sample of 916 trauma-exposed U.S. military veterans were administered the Trauma History Screen, PTSD Checklist-5, and Alcohol Use Disorders Identification Test...
August 6, 2017: Journal of Anxiety Disorders
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