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https://www.readbyqxmd.com/read/29322510/lolium-perenne-peptide-immunotherapy-is-well-tolerated-and-elicits-a-protective-b-cell-response-in-seasonal-allergic-rhinitis-patients
#1
R Mösges, A F Koch, E Raskopf, J Singh, K Shah-Hosseini, B Hauswald, Y Yarin, F Corazza, L Haazen, S Pirotton, S Allekotte, G Zadoyan, T Legon, S R Durham, M H Shamji
BACKGROUND: Systemic allergic reactions are a risk for allergen immunotherapy that utilizes intact allergen preparations. We evaluated the safety, efficacy and immune mechanisms of short-course treatment with adjuvant-free Lolium perenne peptides (LPP) following a 6-week dose-escalation protocol. METHODS: In a prospective, dose-escalation study, 61 grass pollen-allergic patients received 2 subcutaneous injections of LPP once weekly for 6 weeks. Safety was assessed evaluating local reactions, systemic reactions and adverse events...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29322303/salt-tolerance-of-two-perennial-grass-brachypodium-sylvaticum-accessions
#2
Nir Sade, Maria Del Mar Rubio Wilhelmi, Xiaojuan Ke, Yariv Brotman, Matthew Wright, Imran Khan, Wagner De Souza, Elias Bassil, Christian M Tobias, Roger Thilmony, John P Vogel, Eduardo Blumwald
We studied the salt stress tolerance of two accessions isolated from different areas of the world (Norway and Tunisia) and characterized the mechanism(s) regulating salt stress in Brachypodium sylvaticum Osl1 and Ain1. Perennial grasses are widely grown in different parts of the world as an important feedstock for renewable energy. Their perennial nature that reduces management practices and use of energy and agrochemicals give these biomass crops advantages when dealing with modern agriculture challenges such as soil erosion, increase in salinized marginal lands and the runoff of nutrients...
January 10, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29316797/disparities-in-hiv-viral-load-suppression-by-race-ethnicity-among-men-who-have-sex-with-men-in-the-hiv-outpatient-study
#3
Kate Buchacz, Carl Armon, E Tedaldi, Frank J Palella, Richard M Novak, Douglas Ward, Rachel Hart, Marcus Durham, John Brooks
INTRODUCTION: Maximizing the rates of virologic suppression (VS) among gay, bisexual, and other men who have sex with men (MSM) is essential to limiting HIV morbidity and sexual transmission of HIV in the United States. METHODS: We analyzed data for MSM of non-Hispanic white (white), non-Hispanic black (black) or Hispanic/Latino race/ethnicity in the HIV Outpatient Study (HOPS) at nine U.S. HIV clinics. VS (HIV RNA < 50 copies/mL) was measured closest to January 1, 2015...
January 9, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29313570/fosfomycin-susceptibility-in-urinary-tract-enterobacteriaceae
#4
Bhargav Patel, Kinjal Patel, Anjali Shetty, Rajeev Soman, Camilla Rodrigues
Introduction: Antibiotic treatment of Urinary Tract Infections (UTI) is becoming increasingly difficult due to emergence of multi-drug resistant (ESBLs, AmpC, CRE) uropathogens. Fosfomycin is an old antibiotic that has evoked renewed interest with unique properties of not sharing any structural similarity and lack of cross-resistance with other antimicrobial agents. Our aim is to evaluate in-vitro activity of Fosfomycin against urinary tract Enterobacteriaceae. Material & Methods: The study period was March 2014 to September 2015...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29306394/brevetoxin-pbtx-2-influences-the-redox-status-and-npq-of-karenia-brevis-by-way-of-thioredoxin-reductase
#5
Wei Chen, Ricardo Colon, J William Louda, Freddy Rodriguez Del Rey, Michaella Durham, Kathleen S Rein
The Florida red tide dinoflagellate, Karenia brevis, is the major harmful algal bloom dinoflagellate of the Gulf of Mexico and plays a destructive role in the region. Blooms of K. brevis can produce brevetoxins: ladder-shaped polyether (LSP) compounds, which can lead to adverse human health effects, such as reduced respiratory function through inhalation exposure, or neurotoxic shellfish poisoning through consumption of contaminated shellfish. The endogenous role of the brevetoxins remains uncertain. Recent work has shown that some forms of NADPH dependent thioredoxin reductase (NTR) are inhibited by brevetoxin-2 (PbTx-2)...
January 2018: Harmful Algae
https://www.readbyqxmd.com/read/29290411/cmpf-a-metabolite-formed-upon-prescription-omega-3-acid-ethyl-ester-supplementation-prevents-and-reverses-steatosis
#6
Kacey J Prentice, Stacy G Wendell, Ying Liu, Judith A Eversley, Sonia R Salvatore, Haneesha Mohan, Sydney L Brandt, Andrew C Adams, X Serena Wang, David Wei, Garret A FitzGerald, Timothy B Durham, Craig D Hammond, Kyle W Sloop, Carsten Skarke, Francisco J Schopfer, Michael B Wheeler
Prescription ω-3 fatty acid ethyl ester supplements are commonly used for the treatment of hypertriglyceridemia. However, the metabolic profile and effect of the metabolites formed by these treatments remain unknown. Here we utilized unbiased metabolomics to identify 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) as a significant metabolite of the ω-3-acid ethyl ester prescription Lovaza™ in humans. Administration of CMPF to mice before or after high-fat diet feeding at exposures equivalent to those observed in humans increased whole-body lipid metabolism, improved insulin sensitivity, increased beta-oxidation, reduced lipogenic gene expression, and ameliorated steatosis...
December 19, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29284660/the-modern-resource-genome-wide-binding-profiles-for-hundreds-of-drosophila-and-caenorhabditis-elegans-transcription-factors
#7
Michelle M Kudron, Alec Victorsen, Louis Gevirtzman, LaDeana W Hillier, William W Fisher, Dionne Vafeados, Matt Kirkey, Ann S Hammonds, Jeffery Gersch, Haneen Ammouri, Martha L Wall, Jennifer Moran, David Steffen, Matt Szynkarek, Samantha Seabrook-Sturgis, Nader Jameel, Madhura Kadaba, Jaeda Patton, Robert Terrell, Mitch Corson, Timothy J Durham, Soo Park, Swapna Samanta, Mei Han, Jinrui Xu, Koon-Kiu Yan, Susan E Celniker, Kevin P White, Lijia Ma, Mark Gerstein, Valerie Reinke, Robert Waterston
In order to develop a catalog of regulatory sites in two major model organisms, Drosophilia melanogaster and Caenorhabditis elegans, the modERN consortium has systematically assayed the binding sites of transcription factors (TFs). Combined with data produced by our predecessor, modENCODE, we now have data for 262 TFs identifying 1.23M sites in the fly genome and 217 TFs identifying 0.67M sites in the worm genome. Because sites from different TFs are often overlapping and tightly clustered, they fall into 91,011 and 59,150 regions in the fly and worm, respectively, and these binding sites span as little as 8...
December 28, 2017: Genetics
https://www.readbyqxmd.com/read/29284345/from-skin-to-spontaneous-lysis-a-case-of-spontaneous-tumor-lysis-syndrome-in-metastatic-melanoma
#8
Charis G Durham, Jon Herrington, Susan Seago, Chelsea Williams, Mark H Holguin
Tumor lysis syndrome is a life-threatening complication that often occurs after administration of cytotoxic therapy, but rarely occurs spontaneously without chemotherapy. This vignette describes a 59-year-old male with known extensive metastatic melanoma who presented to the hospital with spontaneous tumor lysis syndrome. Most spontaneous tumor lysis cases occur in patients with acute leukemias and aggressive lymphomas; however, this rare case depicts a patient with melanoma developing tumor lysis before the administration of chemotherapy...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29281065/usefulness-of-sealants-for-dural-closure-evaluation-in-an-in-vitro-model
#9
Tristan van Doormaal, Ahmet Kinaci, Sander van Thoor, Saskia Redegeld, Wilhelmina Bergmann, Albert van der Zwan
BACKGROUND: Cerebrospinal fluid (CSF) leakage occurs in 4% to 32% of cranial surgeries and is associated with significant patient burden and expense. The use of sealant as an adjunct to primary dural closure is assumed to help prevent CSF leakage. OBJECTIVE: To examine the utility of different sealants for dural closure using an in Vitro model. METHODS: We evaluated 9 commonly used dural sealants, including Tachosil (Takeda Inc, Osaka, Japan), Adherus (Hyperbranch Inc, Durham, North Carolina), Duraform (Codman, Raynham, Massachusetts), Tissudura (Baxter, Deerfield, Illinois), Hemopatch (Baxter), TissuePatchDural (Tissuemed, Leeds, United Kingdom), Tisseel (Baxter), Duragen Secure (Integra, Plainsboro, New Jersey), and Duraseal, (Integra)...
December 21, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29280845/nurse-perceptions-of-the-family-violence-screening-process-and-education-program-in-a-rural-healthcare-system
#10
Christine Durham-Pressley, Karen Gabel Speroni, Michael J Kingan, Eileen P MacDougall, Michele Williams
No abstract text is available yet for this article.
January 2018: Nursing
https://www.readbyqxmd.com/read/29274534/metagenomic-survey-of-bacterial-diversity-in-the-atmosphere-of-mexico-city-using-different-sampling-methods
#11
N Serrano-Silva, M C Calderón-Ezquerro
The identification of airborne bacteria has traditionally been performed by retrieval in culture media, but the bacterial diversity in the air is underestimated using this method because many bacteria are not readily cultured. Advances in DNA sequencing technology have produced a broad knowledge of genomics and metagenomics, which can greatly improve our ability to identify and study the diversity of airborne bacteria. However, researchers are facing several challenges, particularly the efficient retrieval of low-density microorganisms from the air and the lack of standardized protocols for sample collection and processing...
December 20, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29233081/malkowski-j-2017-dying-in-full-detail-mortality-and-digital-documentary-malkowski-j-2017-dying-in-full-detail-mortality-and-digital-documentary-durham-nc-duke-university-press-264-pp-isbn-978-0-8223-6315-6-23-95-paperback
#12
https://www.readbyqxmd.com/read/29223074/bioaccumulation-and-trophic-transfer-of-cyclic-volatile-methylsiloxanes-cvms-in-the-aquatic-marine-food-webs-of-the-oslofjord-norway
#13
David E Powell, Merete Schøyen, Sigurd Øxnevad, Reinhard Gerhards, Thomas Böhmer, Martin Koerner, Jeremy Durham, Darren W Huff
The trophic transfer of cyclic methylsiloxanes (cVMS) in aquatic ecosystems is an important criterion for assessing bioaccumulation and ecological risk. Bioaccumulation and trophic transfer of cVMS, specifically octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6), were evaluated for the marine food webs of the Inner and Outer Oslofjord, Norway. The sampled food webs included zooplankton, benthic macroinvertebrates, shellfish, and finfish species. Zooplankton, benthic macroinvertebrates, and shellfish occupied the lowest trophic levels (TL ≈2 to 3); northern shrimp (Pandalus borealis) and Atlantic herring (Clupea harengus) occupied the middle trophic levels (TL ≈3 to 4), and Atlantic cod (Gadus morhua) occupied the highest tropic level (TL>4...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29221580/mechanisms-of-allergen-immunotherapy-for-inhaled-allergens-and-predictive-biomarkers
#14
REVIEW
Mohamed H Shamji, Stephen R Durham
Allergen immunotherapy is effective in patients with IgE-dependent allergic rhinitis and asthma. When immunotherapy is given continuously for 3 years, there is persistent clinical benefit for several years after its discontinuation. This disease-modifying effect is both antigen-specific and antigen-driven. Clinical improvement is accompanied by decreases in numbers of effector cells in target organs, including mast cells, basophils, eosinophils, and type 2 innate lymphoid cells. Immunotherapy results in the production of blocking IgG/IgG4 antibodies that can inhibit IgE-dependent activation mediated through both high-affinity IgE receptors (FcεRI) on mast cells and basophils and low-affinity IgE receptors (FcεRII) on B cells...
December 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29212276/low-circulating-levels-of-the-mitochondrial-peptide-hormone-shlp2-novel-biomarker-for-prostate-cancer-risk
#15
Jialin Xiao, Lauren Howard, Junxiang Wan, Emily Wiggins, Adriana Vidal, Pinchas Cohen, Stephen J Freedland
Context: Mitochondrial DNA mutations and dysfunction are associated with prostate cancer (PCa). Small humanin-like peptide-2 (SHLP2) is a novel mitochondrial-encoded peptide and an important mitochondrial retrograde signaling molecule. Objective: To determine whether serum SHLP2 concentration is associated with PCa risk and whether associations are race-specific.Design, Setting and Participants: Patients undergoing prostate biopsy were recruited from the Durham Veterans Affairs hospital...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29203662/methylprednisolone-acetate-induces-and-%C3%AE-7-dafachronic-acid-suppresses-strongyloides-stercoralis-hyperinfection-in-nsg-mice
#16
John B Patton, Sandra Bonne-Année, Jessica Deckman, Jessica A Hess, April Torigian, Thomas J Nolan, Zhu Wang, Steven A Kliewer, Amy C Durham, James J Lee, Mark L Eberhard, David J Mangelsdorf, James B Lok, David Abraham
Strongyloides stercoralis hyperinfection causes high mortality rates in humans, and, while hyperinfection can be induced by immunosuppressive glucocorticoids, the pathogenesis remains unknown. Since immunocompetent mice are resistant to infection with S. stercoralis, we hypothesized that NSG mice, which have a reduced innate immune response and lack adaptive immunity, would be susceptible to the infection and develop hyperinfection. Interestingly, despite the presence of large numbers of adult and first-stage larvae in S...
December 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29203070/a-sirolimus-eluting-bioabsorbable-polymer-coated-stent-mistent-versus-an-everolimus-eluting-durable-polymer-stent-xience-after-percutaneous-coronary-intervention-dessolve-iii-a-randomised-single-blind-multicentre-non-inferiority-phase-3-trial
#17
Robbert J de Winter, Yuki Katagiri, Taku Asano, Krzysztof P Milewski, Philipp Lurz, Pawel Buszman, Gillian A J Jessurun, Karel T Koch, Roland P T Troquay, Bas J B Hamer, Ton Oude Ophuis, Jochen Wöhrle, Rafał Wyderka, Guillaume Cayla, Sjoerd H Hofma, Sébastien Levesque, Aleksander Żurakowski, Dieter Fischer, Maciej Kośmider, Pascal Goube, E Karin Arkenbout, Michel Noutsias, Markus W Ferrari, Yoshinobu Onuma, William Wijns, Patrick W Serruys
BACKGROUND: MiStent is a drug-eluting stent with a fully absorbable polymer coating containing and embedding a microcrystalline form of sirolimus into the vessel wall. It was developed to overcome the limitation of current durable polymer drug-eluting stents eluting amorphous sirolimus. The clinical effect of MiStent sirolimus-eluting stent compared with a durable polymer drug-eluting stents has not been investigated in a large randomised trial in an all-comer population. METHODS: We did a randomised, single-blind, multicentre, phase 3 study (DESSOLVE III) at 20 hospitals in Germany, France, Netherlands, and Poland...
December 1, 2017: Lancet
https://www.readbyqxmd.com/read/29202626/a-nurse-led-and-teacher-assisted-adolescent-healthy-weight-program-to-improve-health-behaviors-in-the-school-setting
#18
Gary Dupart, Diane C Berry, Jennifer D'Auria, Leslie Sharpe, Linda McDonough, Marion Houser, Sarah Flanary, Sadie Koppelberger
Adolescents with overweight and obesity are at risk for future health problems. The purpose of this study was to examine the feasibility and initial efficacy of a weight management intervention to help adolescents develop healthy nutrition and physical activity behaviors and improve their anthropometrics. This study used a single-group repeated measures design in a small school in Durham, North Carolina (NC). The intervention consisted of a nurse-led and teacher-assisted nutrition and physical activity education and exercise classes that met twice each week for 45-60 minutes for 7 weeks...
January 1, 2017: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/29196962/the-moral-injury-symptom-scale-military-version
#19
Harold G Koenig, Donna Ames, Nagy A Youssef, John P Oliver, Fred Volk, Ellen J Teng, Kerry Haynes, Zachary D Erickson, Irina Arnold, Keisha O'Garo, Michelle Pearce
The purpose of this study was to develop a multi-dimensional measure of moral injury symptoms that can be used as a primary outcome measure in intervention studies that target moral injury (MI) in Veterans and Active Duty Military with PTSD. This was a multi-center study of 427 Veterans and Active Duty Military with PTSD symptoms recruited from VA Medical Centers in Augusta, Los Angeles, Durham, Houston, and San Antonio, and from Liberty University in Lynchburg. Internal reliability of the Moral Injury Symptom Scale-Military Version (MISS-M) was examined along with factor analytic, discriminant, and convergent validity...
December 1, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/29196428/measurement-instrument-for-scientific-teaching-mist-a-tool-to-measure-the-frequencies-of-research-based-teaching-practices-in-undergraduate-science-courses
#20
Mary F Durham, Jennifer K Knight, Brian A Couch
The Scientific Teaching (ST) pedagogical framework provides various approaches for science instructors to teach in a way that more closely emulates how science is practiced by actively and inclusively engaging students in their own learning and by making instructional decisions based on student performance data. Fully understanding the impact of ST requires having mechanisms to quantify its implementation. While many useful instruments exist to document teaching practices, these instruments only partially align with the range of practices specified by ST, as described in a recently published taxonomy...
2017: CBE Life Sciences Education
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