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https://www.readbyqxmd.com/read/28077417/aid-is-a-key-regulator-of-myeloid-erythroid-differentiation-and-dna-methylation-in-hematopoietic-stem-progenitor-cells
#1
Hiroyoshi Kunimoto, Anna Sophia McKenney, Cem Meydan, Kaitlyn Shank, Abbas Nazir, Franck Rapaport, Benjamin Durham, Francine E Garrett-Bakelman, Elodie Pronier, Alan H Shih, Ari Melnick, Jayanta Chaudhuri, Ross L Levine
Recent studies have reported activation-induced cytidine deaminase (AID) and ten-eleven-translocation (TET) family members regulate active DNA demethylation. Genetic alterations of TET2 occur in myeloid malignancies and hematopoietic specific loss of Tet2 induces aberrant hematopoietic stem cell (HSC) self-renewal/differentiation, implicating TET2 as a master regulator of normal and malignant hematopoiesis. Despite the functional link between AID and TET in epigenetic gene regulation, the role of AID loss in hematopoiesis and myeloid transformation remains to be investigated...
January 11, 2017: Blood
https://www.readbyqxmd.com/read/28070733/glp-1-ra-treatment-patterns-among-type-2-diabetes-patients-in-five-european-countries
#2
Victoria Divino, Mitch DeKoven, Farhad Ali Khan, Kristina S Boye, Hélène Sapin, Kirsi Norrbacka
INTRODUCTION: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a relatively new class of injectable drugs used in the treatment of type 2 diabetes (T2D). This retrospective database study evaluated real-world treatment patterns of T2D patients initiating GLP-1 RAs in Belgium (BE), France (FR), Germany (DE), The Netherlands (NL) and Sweden (SE). METHODS: Adult T2D patients initiating exenatide twice daily (exBID), exenatide once weekly (exQW), liraglutide (LIRA) or lixisenatide (LIXI) during 2013 were identified using the QuintilesIMS (QuintilesIMS, Durham, NC, and Danbury, CT, USA) longitudinal retail pharmacy databases (LRx; BE/FR/DE/NL) and national health register data (SE)...
January 9, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28067123/the-effect-of-a-supervised-community-based-exercise-program-on-balance-balance-confidence-and-gait-in-individuals-with-lower-limb-amputation
#3
Carol A Miller, Jennifer E Williams, Katey L Durham, Selena C Hom, Julie L Smith
BACKGROUND: Many individuals with lower limb loss report concern with walking ability after completing structured traditional rehabilitation. OBJECTIVES: The purpose of this study was to explore the impact of a supervised community-based exercise program on balance, balance confidence, and gait in individuals with lower limb amputation. STUDY DESIGN: Repeated measures. METHODS: The supervised exercise program was offered biweekly for 6 weeks...
January 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28065341/allergen-immunotherapy-for-a-teenager-with-seasonal-allergic-rhinitis-due-to-grass-pollen-subcutaneous-or-sublingual-route
#4
REVIEW
Harold S Nelson, Stephen R Durham
No abstract text is available yet for this article.
January 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28042190/respiratory-sinus-arrhythmia-and-heart-period-in-infancy-as-correlates-of-later-oppositional-defiant-and-callous-unemotional-behaviors
#5
Nicholas J Wagner, W Roger Mills-Koonce, Michael T Willoughby, Cathi B Propper, Peter D Rehder, Noa Gueron-Sela
Extant literature suggests that oppositional defiant (ODD) and callous-unemotional (CU) behaviors in childhood and adolescence are associated with distinct patterns of psychophysiological functioning and that individual differences in these patterns have implications for developmental pathways to disorder. Very little is known about the associations between psychophysiological functioning in infancy and later ODD and CU behaviors. This study examined associations between basal autonomic nervous system (ANS) functioning in infancy and ODD and CU behaviors in later childhood...
January 2017: International Journal of Behavioral Development
https://www.readbyqxmd.com/read/28033470/developing-a-motion-comic-for-hiv-std-prevention-for-young-people-ages-15-24-part-2-evaluation-of-a-pilot-intervention
#6
Leigh A Willis, Rachel Kachur, Ted J Castellanos, Kristen Nichols, Maria C B Mendoza, Zaneta J Gaul, Pilgrim Spikes, Ashley C Gamayo, Marcus D Durham, Lisa LaPlace, Julie Straw, Colleen Staatz, Hadiza Buge, Matthew Hogben, Susan Robinson, John Brooks, Madeline Y Sutton
In the United States, young people (ages 15-24 years) are disproportionately affected by human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs), due at least in part to inadequate or incorrect HIV/STD-related knowledge, attitudes, beliefs, and behavioral intentions (KABI). Comic book narratives are a proven method of HIV/STD prevention communication to strengthen KABI for HIV/STD prevention. Motion comics, a new type of comic media, are an engaging and low-cost means of narrative storytelling...
December 29, 2016: Health Communication
https://www.readbyqxmd.com/read/28031975/from-ice-to-bugs-polymers-and-sugars-to-address-healthcare-challenges
#7
Matthew I Gibson
Matthew I Gibson talks to Francesca Lake, Managing Editor: After completing his PhD at the University of Durham (UK), Matthew moved to the Ecole Polytechnique Federale de Lausanne (Switzerland) where he researched nanoparticle delivery technology. In 2009, he then moved to the University of Warwick (UK), to establish his independent research group. He has since been promoted to assistant (2012), associate (2015) and full (2016) professor. His interdisciplinary group undertakes research with the core theme of using biomaterials to improve health...
September 2016: Future Science OA
https://www.readbyqxmd.com/read/28018663/geohistorical-records-indicate-no-impact-of-the-deepwater-horizon-oil-spill-on-oyster-body-size
#8
Gregory P Dietl, Stephen R Durham
Documentation of the near- and long-term effects of the Deepwater Horizon (DWH) oil spill, one of the largest environmental disasters in US history, is still ongoing. We used a novel before-after-control-impact analysis to test the hypothesis that average body size of intertidal populations of the eastern oyster (Crassostrea virginica) inhabiting impacted areas in Louisiana decreased due to increased stress/mortality related to the oil spill. Time-averaged death assemblages of oysters were used to establish a pre-spill baseline of body-size structure for four impacted and four control locations along a 350 km stretch of Louisiana's coastline...
November 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/28011659/measuring-health-literacy-in-university-students-in-vientiane-lao-pdr
#9
Laina Runk, Jo Durham, Viengnakhone Vongxay, Vanphanom Sychareun
Health literacy includes the knowledge, motivation and competence of a person to make judgments and decisions on health information in order to promote and maintain their health in relation to health care, disease prevention and health promotion. The role health literacy plays in determining health outcomes makes it an important focus of public health research. In line with a larger Asia wide initiative (HLS-Asia), this study set out to measure health literacy in the Lao People's Democratic Republic (Lao-PDR)...
December 23, 2016: Health Promotion International
https://www.readbyqxmd.com/read/28007984/microbial-competition-in-porous-environments-can-select-against-rapid-biofilm-growth
#10
Katharine Z Coyte, Hervé Tabuteau, Eamonn A Gaffney, Kevin R Foster, William M Durham
Microbes often live in dense communities called biofilms, where competition between strains and species is fundamental to both evolution and community function. Although biofilms are commonly found in soil-like porous environments, the study of microbial interactions has largely focused on biofilms growing on flat, planar surfaces. Here, we use microfluidic experiments, mechanistic models, and game theory to study how porous media hydrodynamics can mediate competition between bacterial genotypes. Our experiments reveal a fundamental challenge faced by microbial strains that live in porous environments: cells that rapidly form biofilms tend to block their access to fluid flow and redirect resources to competitors...
December 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28002553/efficacy-of-staged-excision-with-permanent-section-margin-control-for-cutaneous-head-and-neck-melanoma
#11
Jeffrey S Moyer, Shannon Rudy, Philip S Boonstra, Casey Kraft, Steven B Chinn, Shan R Baker, Jennifer L Schwartz, Christopher K Bichakjian, Douglas Fullen, Alison B Durham, Lori Lowe, Timothy M Johnson
Importance: Melanoma arising in chronically photodamaged skin, especially on the head and neck, is often characterized by poorly defined clinical margins and unpredictable occult extension. Staged excision techniques have been described to treat these challenging melanomas. Objective: To investigate the local recurrence rates and margin to clearance end points using staged excision with comprehensive hematoxylin-eosin-stained permanent section margin control. Design, Setting, and Participants: In this observational cohort study performed from October 8, 1997, to December 31, 2006, with a median follow-up of 9...
December 21, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/28002148/hematuria-incidental-finding-or-a-problem
#12
Catherine O Durham, Elizabeth Harmon, Terri Fowler
No abstract text is available yet for this article.
January 20, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/28001441/developing-a-motion-comic-for-hiv-std-prevention-for-young-people-ages-15-24-part-1-listening-to-your-target-audience
#13
Leigh A Willis, Rachel Kachur, Ted J Castellanos, Pilgrim Spikes, Zaneta J Gaul, Ashley C Gamayo, Marcus Durham, Sandra Jones, Kristen Nichols, Solange Han Barthelemy, Lisa LaPlace, Colleen Staatz, Matthew Hogben, Susan Robinson, John T Brooks, Madeline Y Sutton
Young people (15-24 years) in the United States are disproportionately affected by infection with human immunodeficiency virus (HIV) and sexually transmitted diseases (STD). Shortfalls in HIV/STD-related knowledge, attitudes, beliefs, and behavioral intentions (KABI) likely contribute to this discrepancy. In this report we describe our experience developing a novel means of health communication combining entertainment-education theory and recent technological advances to create a HIV/STD-focused "motion comic...
December 21, 2016: Health Communication
https://www.readbyqxmd.com/read/27998337/vincanne-adams%C3%A2-ed-metrics-what-counts-in-global-health-durham-nc-duke-university-press-2016-pp-258-24-95-paperback-isbn-978-0-8223-6097-1
#14
https://www.readbyqxmd.com/read/27989489/testosterone-pellet-implantation-practices-a-sexual-medicine-society-of-north-america-smsna-member-questionnaire
#15
Michael J Piecuch, Brijesh G Patel, Lawrence Hakim, Run Wang, Hossein Sadeghi-Nejad
INTRODUCTION: There has been renewed interest in the use of subcutaneous testosterone pellets for the treatment of hypogonadism since the introduction of Testopel in 2008 by Slate Pharmaceuticals (Durham, NC, USA). Manufacturer guidelines recommend using two to six pellets; however, in the clinical setting, this is deemed insufficient. This has produced a wide variety of testosterone pellet usage that is not fully understood. AIM: To better understand subcutaneous testosterone pellet implantation practices among members of the Sexual Medicine Society of North America (SMSNA)...
December 15, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27986100/examining-the-sensitivity-and-specificity-of-2-screening-instruments-odontogenic-or-temporomandibular-disorder-pain
#16
Barbara Fonseca Alonso, Donald R Nixdorf, Sarah S Shueb, Mike T John, Alan S Law, Justin Durham
INTRODUCTION: Two groups of patients with orofacial pains that are clinically important to distinguish from each other are patients with odontogenic pain and temporomandibular disorder (TMD) pain. The aim of this study was to determine the sensitivity and specificity of 2 screening instruments in distinguishing between patients with these types of pain. METHODS: A convenience sample of patients seeking care at an endodontic clinic and an orofacial pain clinic were recruited...
January 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/27981266/initial-accuracy-assessment-of-the-modified-s-lanss-for-the-detection-of-neuropathic-orofacial-pain-conditions
#17
Alberto Herrero Babiloni, Donald R Nixdorf, Alan S Law, Estephan J Moana-Filho, Sarah S Shueb, Ruby H Nguyen, Justin Durham
OBJECTIVE: To evaluate the accuracy of a questionnaire modified for the identification of intraoral pain with neuropathic characteristics in a clinical orofacial pain sample population. METHOD AND MATERIALS: 136 participants with at least one of four orofacial pain diagnoses (temporomandibular disorders [TMD, n = 41], acute dental pain [ADP, n = 41], trigeminal neuralgia [TN, n = 19], persistent dentoalveolar pain disorder [PDAP, n = 14]) and a group of pain-free controls (n = 21) completed the modified S-LANSS, a previously adapted version of the original questionnaire devised to detected patients suffering from intraoral pain with neuropathic characteristics...
December 15, 2016: Quintessence International
https://www.readbyqxmd.com/read/27959899/effects-of-in-utero-thyroxine-exposure-on-murine-cranial-suture-growth
#18
R Nicole Howie, Emily L Durham, Laurel Black, Grace Bennfors, Trish E Parsons, Mohammed E Elsalanty, Jack C Yu, Seth M Weinberg, James J Cray
Large scale surveillance studies, case studies, as well as cohort studies have identified the influence of thyroid hormones on calvarial growth and development. Surveillance data suggests maternal thyroid disorders (hyperthyroidism, hypothyroidism with pharmacological replacement, and Maternal Graves Disease) are linked to as much as a 2.5 fold increased risk for craniosynostosis. Craniosynostosis is the premature fusion of one or more calvarial growth sites (sutures) prior to the completion of brain expansion...
2016: PloS One
https://www.readbyqxmd.com/read/27959871/seasonal-influence-of-environmental-variables-and-artificial-aeration-on-escherichia-coli-in-small-urban-lakes
#19
Bart W Durham, Lucy Porter, Allie Webb, Joshua Thomas
This study investigated patterns of Escherichia coli in urban lakes in Lubbock, Texas. Specific objectives were to (1) document seasonal patterns in abundance of E. coli over a 3-year period, (2) identify environmental factors, including effects of migratory geese and artificial aeration devices that may influence E. coli abundance, and (3) determine if E. coli abundance over time was similar for individual lakes. Water samples were collected monthly for 36 months from six lakes, three of which contained artificial aeration devices (fountains)...
December 2016: Journal of Water and Health
https://www.readbyqxmd.com/read/27941039/targeted-response-an-exploration-of-why-ambulance-services-find-government-targets-particularly-challenging
#20
REVIEW
Mark Durham, Mark Faulkner, Charles Deakin
INTRODUCTION OR BACKGROUND: Ambulance services have historically found their targets particularly challenging. This article explores some areas of this multifaceted problem. SOURCES OF DATA: Research articles, government publications and published audit data. AREAS OF AGREEMENT: Demand is increasing in many areas of healthcare, but whilst hospitals saw a 7% increase in demand in recent times, ambulance services saw nearly double that. The services ambulance trusts provide have evolved from that of a transport service to that of a mobile health provider, and they have become victims of their own success...
December 2016: British Medical Bulletin
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